200 results on '"Capel B"'
Search Results
2. The Genetic Basis of XX-XY Differences Present before Gonadal Sex Differentiation in the Mouse [and Discussion]
- Author
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Burgoyne, P. S., Thornhill, A. R., Boudrean, S. Kalmus, Darling, S. M., Bishop, C. E., Evans, E. P., Capel, B., and Mittwoch, U.
- Published
- 1995
3. The Molecular Biology of Temperature-Dependent Sex Determination [and Discussion]
- Author
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Johnston, C. M., Barnett, M., Sharpe, P. T., Graves, J. A. M., Renfree, M. B., Capel, B., and Mireille, D.
- Published
- 1995
4. Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates: O-259
- Author
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Capel, B., Mork, L., Maatouk, D. M., McMahon, J. A., McMahon, A. P., and Zhang, P.
- Published
- 2012
5. Y353/B: a candidate multiple-copy spermiogenesis gene on the mouse Y chromosome
- Author
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Conway, S. J., Mahadevaiah, S. K., Darling, S. M., Capel, B., Rattigan, A. M., and Burgoyne, P. S.
- Published
- 1994
- Full Text
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6. Effect of the relative shift between the electron density and temperature pedestal position on the pedestal stability in JET-ILW and comparison with JET-C
- Author
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Stefanikova, E., Frassinetti, L., Saarelma, S., Loarte, A., Nunes, I., Garzotti, L., Lomas, P., Rimini, F., Drewelow, P., Kruezi, U., Lomanowski, B., De La Luna, E., Meneses, L., Peterka, M., Viola, B., Giroud, C., Litaudon, Maggi C., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. A., Barnes, D., Barnsley, M., Baron, Wiechec, Barrera, Orte, Baruzzo, L., Matteo, Basiuk, Bassan, V., Bastow, M., Batista, R., Batistoni, A., Baughan, P., Bauvir, R., Baylor, B., Bazylev, L., Beal, B., Beaumont, J., Beckers, P. S., Beckett, M., Becoulet, B., Bekris, A., Beldishevski, N., Bell, M., Belli, K., Bellinger, F., Belonohy, M., Ben, Ayed, Benterman, N., Bergsã¥ker, N. A., Bernardo, H., Bernert, J., Berry, M., Bertalot, M., Besliu, L., Beurskens, C., Bieg, M., Bielecki, B., Biewer, J., Bigi, T., Bã¬lkovã¡, M., Binda, P., Bisoffi, F., Bizarro, A., Bjã¶rkas, J. P. S., Blackburn, C., Blackman, J., Blackman, K., Blanchard, T. R., Blatchford, P., Bobkov, P., Boboc, V., Bodnã¡r, A., Bogar, G., Bolshakova, O., Bolzonella, I., Tommaso, Bonanomi, Bonelli, N., Boom, F., Booth, J., Borba, J., Borodin, D., Borodkina, D., Botrugno, I., Bottereau, A., Boulting, C., Bourdelle, P., Bowden, C., Bower, M., Bowman, C., Boyce, C., Boyd, T., Boyer, C., Bradshaw, H. J., Braic, J. M. A., Bravanec, V., Breizman, R., Bremond, B., Brennan, S., Breton, P. D., Brett, S., Brezinsek, A., Bright, S., Brix, M. D. J., Broeckx, M., Brombin, W., Matteo, Broså‚awski, Brown, A., Brown, D. P. D., Bruno, M., Bucalossi, E., Buch, J., Buchanan, J., Buckley, J., Budny, M. A., Bufferand, R., Bulman, H., Bulmer, M., Bunting, N., Buratti, P., Burckhart, P., Buscarino, A., Busse, A., Butler, A., Bykov, N. K., Byrne, I., Cahyna, J., Calabrã², P., Calvo, G., Camenen, I., Camp, Y., Campling, P., Cane, D. C., Cannas, J., Capel, B., Card, A. J., Cardinali, P. J., Carman, A., Carr, P., Carralero, M., Carraro, D., Carvalho, L., Carvalho, B. B., Carvalho, I., Casson, P., Castaldo, F. J., Catarino, C., Caumont, N., Causa, J., Cavazzana, F., Cave, Ayland, Cavinato, K., Cecconello, M., Ceccuzzi, M., Cecil, S., Cenedese, E., Angelo, Cesario, Challis, R., Chandler, C. D., Chandra, M., Chang, D., Chankin, C. S., Chapman, A., Chapman, I. T., Chernyshova, S. C., Chitarin, M., Giuseppe, Ciraolo, Ciric, G., Citrin, D., Clairet, J., Clark, F., Clark, E., Clarkson, M., Clatworthy, R., Clements, D., Cleverly, C., Coad, M., Coates, J. P., Cobalt, P. A., Coccorese, A., Cocilovo, V., Coda, V., Coelho, S., Coenen, R., Coffey, J. W., Colas, I., Collins, L., Conka, S., Conroy, D., Conway, S., Coombs, N., Cooper, D., Corradino, S. R., Corre, C., Corrigan, Y., Cortes, G., Coster, S., Couchman, D., Cox, A. S., Craciunescu, M. P., Cramp, T., Craven, S., Crisanti, R., Croci, F., Croft, G., Crombã©, D., Crowe, K., Cruz, R., Cseh, N., Cufar, G., Cullen, A., Curuia, A., Czarnecka, M., Dabirikhah, A., Dalgliesh, H., Dalley, P., Dankowski, S., Darrow, J., Davies, D., Davis, O., Day, W., Day, C., I. E., Bock, De, Castro, De, De La Cal, De La Luna, Masi, De, Pablos, De, J. L., Temmerman, De, Tommasi, De, Vries, De, Deakin, P., Deane, K., Degli, Agostini, Dejarnac, F., Delabie, R., Den, Harder, Dendy, N., Denis, R. O., Denner, J., Devaux, P., Devynck, S., Maio, Di, Siena, Di, Troia, Di, Dinca, C., D'Inca, P., Ding, R., Dittmar, B., Doerk, T., Doerner, H., Donnã©, R. P., Dorling, T., S. E., Dormido, Canto, Doswon, S., Douai, S., Doyle, D., Drenik, P. T., Drewelow, A., Drews, P., Duckworth, P., Dumont, P. h., Dumortier, R., Dunai, P., Dunne, D., Äžuran, M., Durodiã©, I., Dutta, F., Duval, P., Dux, B. P., Dylst, R., Dzysiuk, K., Edappala, N., Edmond, P. V., Edwards, J., Edwards, A. M., Eich, J., Ekedahl, T. h., Jorf, El, Elsmore, R., Enachescu, C. G., Ericsson, M., Eriksson, G., Eriksson, F., Eriksson, J., Esposito, L. G., Esquembri, B., Esser, S., Esteve, H. G., Evans, D., Evans, B., Evison, G. E., Ewart, G., Fagan, G. D., Faitsch, D., Falie, M., Fanni, D., Fasoli, A., Faustin, A., Fawlk, J. M., Fazendeiro, N., Fedorczak, L., Felton, N., Fenton, R. C., Fernades, K., Fernandes, A., Ferreira, H., Fessey, J., Fã©vrier, J. A., Ficker, O., Field, O., Fietz, A., Figueiredo, S., Figueiredo, A., Fil, J., Finburg, A., Firdaouss, P., Fischer, M., Fittill, U., Fitzgerald, L., Flammini, M., Flanagan, D., Fleming, J., Flinders, C., Fonnesu, K., Fontdecaba, N., Formisano, J. M., Forsythe, A., Fortuna, L., Fortuna, Zalesna, Fortune, E., Foster, M., Franke, S., Franklin, T., Frasca, T., Frassinetti, M., Freisinger, L., Fresa, M., Frigione, R., Fuchs, D., Fuller, V., Futatani, D., Fyvie, S., Gã¡l, J., Galassi, K., Gaå‚azka, D., Galdon, Quiroga, Gallagher, J., Gallart, J., Galvã¡o, D., Gao, R., Gao, X., Garcia, Y., Garcia, Carrasco, Garcã¬a, Muã±oz, Gardarein, M., Garzotti, J. L., Gaudio, L., Gauthier, P., Gear, E., Gee, D. F., Geiger, S. J., Gelfusa, B., Gerasimov, M., Gervasini, S., Gethins, G., Ghani, M., Ghate, Z., Gherendi, M., Giacalone, M., Giacomelli, J. C., Gibson, L., Giegerich, C. S., Gil, T., Gil, C., Gilligan, L., Gin, S., Giovannozzi, D., Girardo, E., Giroud, J. B., Giruzzi, C., Gerardo, Glã¶ggler, Godwin, S., Goff, J., Gohil, J., Goloborod'Ko, P., Gomes, V., Goncalves, R., Goniche, B., Goodliffe, M., Goodyear, M., Gorini, A., Gosk, G., Goulding, M., Goussarov, R., Gowland, A., Graham, R., Graham, B., Graves, M. E., Grazier, J. P., Grazier, N., Green, P., Greuner, N. R., Grierson, H., Griph, B., Grisolia, F. S., Grist, C., Groth, D., Grove, M., Grundy, R., Grzonka, C. N., Guard, J., Guã©rard, D., Guillemaut, C., Guirlet, C., Gurl, R., Utoh, C., Hackett, H. H., Hacquin, L. J., Hagar, S., Hager, A., Hakola, R., Halitovs, A., Hall, M., S. J., Hallworth, Cook, S. P., Hamlyn, Harris, Hammond, C., Harrington, K., Harrison, C., Harting, J., Hasenbeck, D., Hatano, F., Hatch, Y., Haupt, D. R., Hawes, T. D. V., Hawkes, J., Hawkins, N. C., Hawkins, J., Haydon, P., Hayter, P. W., Hazel, N., Heesterman, S., Heinola, P. J. L., Hellesen, K., Hellsten, C., Helou, T., Hemming, W., Hender, O. N., Henderson, T. C., Henderson, M., Henriques, S. S., Hepple, R., Hermon, D., Hertout, G., Hidalgo, P., Highcock, C., Hill, E. G., Hillairet, M., Hillesheim, J., Hillis, J., Hizanidis, D., Hjalmarsson, K., Hobirk, A., Hodille, J., Hogben, E., Hogeweij, C. H. A., Hollingsworth, G. M. D., Hollis, A., Homfray, S., Horã¡äek, D. A., Hornung, J., Horton, G., Horton, A. R., Horvath, L. D., Hotchin, L., Hough, S. P., Howarth, M. R., Hubbard, P. J., Huber, A., Huddleston, V., Hughes, T. M., Huijsmans, M., Hunter, G. T. A., Huynh, C. L., Hynes, P., Iglesias, A. M., Imazawa, D., Imbeaux, N., Imrã¬å¡ek, F., Incelli, M., Innocente, M., Irishkin, P., Ivanova, Stanik, Jachmich, I., Jacobsen, S., Jacquet, A. S., Jansons, P., Jardin, J., Jã¤rvinen, A., Jaulmes, A., Jednorã³g, F., Jenkins, S., Jeong, I., Jepu, C., Joffrin, I., Johnson, E., Johnson, R., Johnston, T., Jane, Joita, Jones, L., Jones, G., Hoshino, T. T. C., Kallenbach, K. K., Kamiya, A., Kaniewski, K., Kantor, J., Kappatou, A., Karhunen, A., Karkinsky, J., Karnowska, D., Kaufman, I., Kaveney, M., Kazakov, G., Kazantzidis, Y., Keeling, V., Keenan, D. L., Keep, T., Kempenaars, J., Kennedy, M., Kenny, C., Kent, D., Kent, J., Khilkevich, O. N., Kim, E., Kim, H. T., Kinch, H. S., King, A., King, C., King, D., Kinna, R. F., Kiptily, D. J., Kirk, V., Kirov, A., Kirschner, K., Kizane, A., Klepper, G., Klix, C., Knight, A., Knipe, P., Knott, S. J., Kobuchi, S., Kã¶chl, T., Kocsis, F., Kodeli, G., Kogan, I., Kogut, L., Koivuranta, D., Kominis, S., Kã¶ppen, Y., Kos, M., Koskela, B., Koslowski, T., Koubiti, H. R., Kovari, M., Kowalska, Strzè©ciwilk, Krasilnikov, E., Krasilnikov, A., Krawczyk, V., Kresina, N., Krieger, M., Krivska, K., Kruezi, A., Ksiaå¼ek, U., Kukushkin, I., Kundu, A., Kurki, Suonio, Kwak, T., Kwiatkowski, S., Kwon, R., Laguardia, O. J., Lahtinen, L., Laing, A., Lam, A., Lambertz, N., Lane, H. T., Lang, C., Lanthaler, P. T., Lapins, S., Lasa, J., Last, A., Åaszyå„ska, J. R., Lawless, E., Lawson, R., Lawson, A., Lazaros, K. D., Lazzaro, A., Leddy, E., Lee, J., Lefebvre, S., Leggate, X., Lehmann, H. J., Lehnen, J., Leichtle, M., Leichuer, D., Leipold, P., Lengar, F., Lennholm, I., Lerche, M., Lescinskis, E., Lesnoj, A., Letellier, S., Leyland, E., Leysen, M., Li, W., Liang, L., Likonen, Y., Linke, J., Linsmeier, J., Lipschultz, C. h., Liu, B., Liu, G., Schiavo, Lo, Loarer, V. P., Loarte, T., Lobel, A., Lomanowski, R. C., Lomas, B., Lã¶nnroth, P. J., Lã³pez, J., J. M., Lã³pez, Razola, Lorenzini, J., Losada, R., Lovell, U., Loving, J. J., Lowry, A. B., Luce, C., Lucock, T., Lukin, R. M. A., Luna, A., Lungaroni, C., Lungu, M., Lungu, C. P., Lunniss, M., Lupelli, A., Lyssoivan, I., Macdonald, A., Macheta, N., Maczewa, P., Magesh, K., Maget, B., Maggi, P., Maier, C., Mailloux, H., Makkonen, J., Makwana, T., Malaquias, R., Malizia, A., Manas, A., Manning, P., Manso, A., Mantica, M. E., Mantsinen, P., Manzanares, M., Maquet, A., Marandet, P. h., Marcenko, Y., Marchetto, N., Marchuk, C., Marinelli, O., Marinucci, M., Markoviä, M., Marocco, T., Marot, D., Marren, L., Marshal, C. A., Martin, R., Martin, A., Martìn De Aguilera, Martã¬nez, A., F. J., Martã¬n, Solã¬s, Martynova, J. R., Maruyama, Y., Masiello, S., Maslov, A., Matejcik, M., Mattei, S., Matthews, M., Maviglia, G. F., Mayer, F., Mayoral, M., M. L., May, Smith, Mazon, T., Mazzotta, D., Mcadams, C., Mccarthy, R., Mcclements, P. J., Mccormack, K. G., Mccullen, O., Mcdonald, P. A., Mcintosh, D., Mckean, S., Mckehon, R., Meadows, J., Meakins, R. C., Medina, A., Medland, F., Medley, M., Meigh, S., Meigs, S., Meisl, A. G., Meitner, G., Meneses, S., Menmuir, L., Mergia, S., Merrigan, K., Mertens, I. R., Meshchaninov, P. h., Messiaen, S., Meyer, A., Mianowski, H., Michling, S., Middleton, Gear, Miettunen, D., Militello, J., Militello, Asp, Miloshevsky, E., Mink, G., Minucci, F., Miyoshi, S., Mlynã¡å™, Y., Molina, J., Monakhov, D., Moneti, I., Mooney, M., Moradi, R., Mordijck, S., Moreira, S., Moreno, L., Moro, R., Morris, F., Morris, A. W., Moser, J., Mosher, L., Moulton, S., Murari, D., Muraro, A., Murphy, A., Asakura, S., N. N., Na, Nabais, Y. S., Naish, F., Nakano, R., Nardon, T., Naulin, E., Nave, V., Nedzelski, M. F. F., Nemtsev, I., Nespoli, G., Neto, F., Neu, A., Neverov, R., Newman, V. S., Nicholls, M., Nicolas, K. J., Nielsen, T., Nielsen, A. H., Nilsson, P., Nishijima, E., Noble, D., Nocente, C., Nodwell, M., Nordlund, D., Nordman, K., Nouailletas, H., Nunes, R., Oberkofler, I., Odupitan, M., Ogawa, T., O'Gorman, M. T., Okabayashi, T., Olney, M., Omolayo, R., O'Mullane, O., Ongena, M., Orsitto, J., Orszagh, F., Oswuigwe, J., Otin, B. I., Owen, R., Paccagnella, A., Pace, R., Pacella, N., Packer, D., Page, L. W., Pajuste, A., Palazzo, E., Pamela, S., Panja, S., Papp, S., Paprok, P., Parail, R., Park, V., Parra, Diaz, Parsons, F., Pasqualotto, M., Patel, R., Pathak, A., Paton, S., Patten, D., Pau, H., Pawelec, A., Paz, Soldan, Peackoc, C., Pearson, A., Pehkonen, I. J., Peluso, S. P., Penot, E., Pereira, C., Pereira, A., Pereira, Puglia, P. P., Perez Von Thun, Peruzzo, C., Peschanyi, S., Peterka, S., Petersson, M., Petravich, P., Petre, G., Petrella, A., Petrå¾ilka, N., Peysson, V., Pfefferlã©, Y., Philipps, D., Pillon, V., Pintsuk, M., Piovesan, G., Pires Dos Reis, Piron, Lidia, Pironti, A., Pisano, F., Pitts, R., Pizzo, F., Plyusnin, V., Pomaro, N., Pompilian, O. G., Pool, P. J., Popovichev, S., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Powell, T., Pozzi, J., Prajapati, V., Prakash, R., Prestopino, G., Price, D., Price, M., Price, R., Prior, P., Proudfoot, R., Pucella, G., Puglia, P., Puiatti, M. E., Pulley, D., Purahoo, K., Pã¼tterich, T. h., Rachlew, E., Rack, M., Ragona, R., Rainford, M. S. J., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, J. J., Rathod, K., Rattã¡, G., Ratynskaia, S., Ravera, G., Rayner, C., Rebai, M., Reece, D., Reed, A., Rã©fy, D., Regan, B., Regaã±a, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes, Cortes, Reynolds, S. D. A., Riccardo, S., Richardson, V., Riddle, N., Rigamonti, K., Rimini, D., Risner, F. G., Riva, J., Roach, M., Robins, C., Robinson, R. J., Robinson, S. A., Robson, T., Roccella, D. W., Rodionov, R., Rodrigues, R., Rodriguez, P., Rohde, J., Romanelli, V., Romanelli, F., Romanelli, M., Romazanov, S., Rowe, J., Rubel, S., Rubinacci, M., Rubino, G., Ruchko, G., Ruiz, L., Ruset, M., Rzadkiewicz, C., Saarelma, J., Sabot, S., Safi, R., Sagar, E., Saibene, P., Saint, Laurent, Salewski, F., Salmi, M., Salmon, A., Salzedas, R., Samaddar, F., Samm, D., Sandiford, U., Santa, D., Santala, P., Santos, M. I. K., Santucci, B., Sartori, A., Sartori, F., Sauter, R., Scannell, O., Schlummer, R., Schmid, T., Schmidt, K., Schmuck, V., Schneider, S., Schã¶pf, M., Schwã¶rer, K., Scott, D., Sergienko, S. D., Sertoli, G., Shabbir, M., Sharapov, A., Shaw, S. E., Shaw, A., Sheikh, R., Shepherd, H., Shevelev, A., Shumack, A., Sias, A., Sibbald, G., Sieglin, M., Silburn, B., Silva, S., Silva, A., Simmons, C., Simpson, P. A., Simpson, Hutchinson, Sinha, J., Sipilã¤, A., Sips, S. K., Sirã©n, A. C. C., Sirinelli, P., Sjã¶strand, A., Skiba, H., Skilton, M., Slabkowska, R., Slade, K., Smith, B., Smith, N., Smith, P. G., Smith, R., Smithies, T. J., Snoj, M., Soare, L., Solano, S., Somers, E. R., Sommariva, A., Sonato, C., Piergiorgio, Sopplesa, Sousa, A., Sozzi, J., Spagnolo, C., Silvia, Spelzini, Spineanu, T., Stables, F., Stamatelatos, G., Stamp, I., Staniec, M. F., Stankå«nas, P., Stan, Sion, Stead, C., Stefanikova, M. J., Stepanov, E., Stephen, I., Stephen, A. V., Stevens, M., Stevens, A., Strachan, B. D., Strand, J., Strauss, P., Strã¶m, H. R., Stubbs, P., Studholme, G., Subba, W., Summers, F., Svensson, H. P., Åšwiderski, J., Szabolics, Å. ., Szawlowski, T., Szepesi, M., Suzuki, G., Tã¡l, T. T., Tala, B., Talbot, T., Talebzadeh, A. R., Taliercio, S., Cesare, Tamain, Tame, P., Tang, C., Tardocchi, W., Taroni, M., Taylor, L., Taylor, D., Tegnered, K. A., Telesca, D., Teplova, G., Terranova, N., David, Testa, Tholerus, D., Thomas, E., Thomas, J., Thomas, J. D., Thompson, P., Thompson, A., Thompson, C. A., Thorne, V. K., Thornton, L., Thrysã¸e, A., Tigwell, A. S., Tipton, P. A., Tiseanu, N., Tojo, I., Tokitani, H., Tolias, M., Tomeå¡, P., Tonner, M., Towndrow, P., Trimble, M., Tripsky, P., Tsalas, M., Tsavalas, M., Tskhakaya, Jun, Turner, D., Turner, I., Turnyanskiy, M. M., Tvalashvili, M., Tyrrell, G., Uccello, S. G. J., Abidin, Ul, Uljanovs, Z., Ulyatt, J., Urano, D., Uytdenhouwen, H., Vadgama, I., Valcarcel, A. P., Valentinuzzi, D., Valisa, M., Vallejos, Olivares, Valovic, P., Van De Mortel, Van, Eester, Van, Renterghem, Van, Rooij, Varje, G. J., Varoutis, J., Vartanian, S., Vasava, S., Vasilopoulou, K., Vega, T., Verdoolaege, J., Verhoeven, G., Verona, R., Verona, Rinati, Veshchev, G., Vianello, E., Vicente, N., Viezzer, J., Villari, E., Villone, S., Vincenzi, F., Pietro, Vinyar, Viola, I., Vitins, B., Vizvary, A., Vlad, Z., Voitsekhovitch, M., Vondrã¡äek, I., Vora, P., Vu, N., Pires De Sa, Wakeling, W. W., Waldon, B., Walkden, C. W. F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., I, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. RNM138: Física Nuclear Aplicada, JET Contributors, Viola, B., Department of Physics, and Materials Physics
- Subjects
Nuclear and High Energy Physics ,Electron density ,Materials science ,Physics::Instrumentation and Detectors ,Thomson scattering ,education ,114 Physical sciences ,01 natural sciences ,010305 fluids & plasmas ,Pedestal ,ASDEX Upgrade ,Physics::Plasma Physics ,Position (vector) ,0103 physical sciences ,Pedestal position ,pedestal stability ,010306 general physics ,Jet (fluid) ,EUROPED ,JET ,pedestal ,pedestal position ,Pedestal stability ,Plasma ,Condensed Matter Physics ,Electron temperature ,Atomic physics ,physics - Abstract
The electron temperature and density pedestals tend to vary in their relative radial positions, as observed in DIII-D (Beurskens et al 2011 Phys. Plasmas 18 056120) and ASDEX Upgrade (Dunne et al 2017 Plasma Phys. Control. Fusion 59 14017). This so-called relative shift has an impact on the pedestal magnetohydrodynamic (MHD) stability and hence on the pedestal height (Osborne et al 2015 Nucl. Fusion 55 063018). The present work studies the effect of the relative shift on pedestal stability of JET ITER-like wall (JET-ILW) baseline low triangularity (δ) unseeded plasmas, and similar JET-C discharges. As shown in this paper, the increase of the pedestal relative shift is correlated with the reduction of the normalized pressure gradient, therefore playing a strong role in pedestal stability. Furthermore, JET-ILW tends to have a larger relative shift compared to JET carbon wall (JET-C), suggesting a possible role of the plasma facing materials in affecting the density profile location. Experimental results are then compared with stability analysis performed in terms of the peeling-ballooning model and with pedestal predictive model EUROPED (Saarelma et al 2017 Plasma Phys. Control. Fusion). Stability analysis is consistent with the experimental findings, showing an improvement of the pedestal stability, when the relative shift is reduced. This has been ascribed mainly to the increase of the edge bootstrap current, and to minor effects related to the increase of the pedestal pressure gradient and narrowing of the pedestal pressure width. Pedestal predictive model EUROPED shows a qualitative agreement with experiment, especially for low values of the relative shift. EURATOM 633053 Swedish Energy Agency 40146-1
- Published
- 2018
7. Erosion and deposition in the JET divertor during the second ITER-like wall campaign
- Author
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Mayer, M., Krat, S., Baron-Wiechec, A., Gasparyan, Y., Heinola, K., Koivuranta, S., Likonen, J., Ruset, C., De Saint-Aubin, G., Litaudon, Widdowson A., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. A., Barnes, D., Barnsley, M., Baron, Wiechec, Barrera, Orte, Baruzzo, L., Matteo, Basiuk, Bassan, V., Bastow, M., Batista, R., Batistoni, A., Baughan, P., Bauvir, R., Baylor, B., Bazylev, L., Beal, B., Beaumont, J., Beckers, P. S., Beckett, M., Becoulet, B., Bekris, A., Beldishevski, N., Bell, M., Belli, K., Bellinger, F., Belonohy, M., Ben, Ayed, Benterman, N., Bergsã¥ker, N. A., Bernardo, H., Bernert, J., Berry, M., Bertalot, M., Besliu, L., Beurskens, C., Bieg, M., Bielecki, B., Biewer, J., Bigi, T., Bã¬lkovã¡, M., Binda, P., Bisoffi, F., Bizarro, A., Bjã¶rkas, J. P. S., Blackburn, C., Blackman, J., Blackman, K., Blanchard, T. R., Blatchford, P., Bobkov, P., Boboc, V., Bodnã¡r, A., Bogar, G., Bolshakova, O., Bolzonella, I., Tommaso, Bonanomi, Bonelli, N., Boom, F., Booth, J., Borba, J., Borodin, D., Borodkina, D., Botrugno, I., Bottereau, A., Boulting, C., Bourdelle, P., Bowden, C., Bower, M., Bowman, C., Boyce, C., Boyd, T., Boyer, C., Bradshaw, H. J., Braic, J. M. A., Bravanec, V., Breizman, R., Bremond, B., Brennan, S., Breton, P. D., Brett, S., Brezinsek, A., Bright, S., Brix, M. D. J., Broeckx, M., Brombin, W., Matteo, Broså‚awski, Brown, A., Brown, D. P. D., Bruno, M., Bucalossi, E., Buch, J., Buchanan, J., Buckley, J., Budny, M. A., Bufferand, R., Bulman, H., Bulmer, M., Bunting, N., Buratti, P., Burckhart, P., Buscarino, A., Busse, A., Butler, A., Bykov, N. K., Byrne, I., Cahyna, J., Calabrã², P., Calvo, G., Camenen, I., Camp, Y., Campling, P., Cane, D. C., Cannas, J., Capel, B., Card, A. J., Cardinali, P. J., Carman, A., Carr, P., Carralero, M., Carraro, D., Carvalho, L., Carvalho, B. B., Carvalho, I., Casson, P., Castaldo, F. J., Catarino, C., Caumont, N., Causa, J., Cavazzana, F., Cave, Ayland, Cavinato, K., Cecconello, M., Ceccuzzi, M., Cecil, S., Cenedese, E., Angelo, Cesario, Challis, R., Chandler, C. D., Chandra, M., Chang, D., Chankin, C. S., Chapman, A., Chapman, I. T., Chernyshova, S. C., Chitarin, M., Giuseppe, Ciraolo, Ciric, G., Citrin, D., Clairet, J., Clark, F., Clark, E., Clarkson, M., Clatworthy, R., Clements, D., Cleverly, C., Coad, M., Coates, J. P., Cobalt, P. A., Coccorese, A., Cocilovo, V., Coda, V., Coelho, S., Coenen, R., Coffey, J. W., Colas, I., Collins, L., Conka, S., Conroy, D., Conway, S., Coombs, N., Cooper, D., Corradino, S. R., Corre, C., Corrigan, Y., Cortes, G., Coster, S., Couchman, D., Cox, A. S., Craciunescu, M. P., Cramp, T., Craven, S., Crisanti, R., Croci, F., Croft, G., Crombã©, D., Crowe, K., Cruz, R., Cseh, N., Cufar, G., Cullen, A., Curuia, A., Czarnecka, M., Dabirikhah, A., Dalgliesh, H., Dalley, P., Dankowski, S., Darrow, J., Davies, D., Davis, O., Day, W., Day, C., I. E., Bock, De, Castro, De, De La Cal, De La Luna, Masi, De, Pablos, De, J. L., Temmerman, De, Tommasi, De, Vries, De, Deakin, P., Deane, K., Degli, Agostini, Dejarnac, F., Delabie, R., Den, Harder, Dendy, N., Denis, R. O., Denner, J., Devaux, P., Devynck, S., Maio, Di, Siena, Di, Troia, Di, Dinca, C., D'Inca, P., Ding, R., Dittmar, B., Doerk, T., Doerner, H., Donnã©, R. P., Dorling, T., S. E., Dormido, Canto, Doswon, S., Douai, S., Doyle, D., Drenik, P. T., Drewelow, A., Drews, P., Duckworth, P., Dumont, P. h., Dumortier, R., Dunai, P., Dunne, D., Äžuran, M., Durodiã©, I., Dutta, F., Duval, P., Dux, B. P., Dylst, R., Dzysiuk, K., Edappala, N., Edmond, P. V., Edwards, J., Edwards, A. M., Eich, J., Ekedahl, T. h., Jorf, El, Elsmore, R., Enachescu, C. G., Ericsson, M., Eriksson, G., Eriksson, F., Eriksson, J., Esposito, L. G., Esquembri, B., Esser, S., Esteve, H. G., Evans, D., Evans, B., Evison, G. E., Ewart, G., Fagan, G. D., Faitsch, D., Falie, M., Fanni, D., Fasoli, A., Faustin, A., Fawlk, J. M., Fazendeiro, N., Fedorczak, L., Felton, N., Fenton, R. C., Fernades, K., Fernandes, A., Ferreira, H., Fessey, J., Fã©vrier, J. A., Ficker, O., Field, O., Fietz, A., Figueiredo, S., Figueiredo, A., Fil, J., Finburg, A., Firdaouss, P., Fischer, M., Fittill, U., Fitzgerald, L., Flammini, M., Flanagan, D., Fleming, J., Flinders, C., Fonnesu, K., Fontdecaba, N., Formisano, J. M., Forsythe, A., Fortuna, L., Fortuna, Zalesna, Fortune, E., Foster, M., Franke, S., Franklin, T., Frasca, T., Frassinetti, M., Freisinger, L., Fresa, M., Frigione, R., Fuchs, D., Fuller, V., Futatani, D., Fyvie, S., Gã¡l, J., Galassi, K., Gaå‚azka, D., Galdon, Quiroga, Gallagher, J., Gallart, J., Galvã¡o, D., Gao, R., Gao, X., Garcia, Y., Garcia, Carrasco, Garcã¬a, Muã±oz, Gardarein, M., Garzotti, J. L., Gaudio, L., Gauthier, P., Gear, E., Gee, D. F., Geiger, S. J., Gelfusa, B., Gerasimov, M., Gervasini, S., Gethins, G., Ghani, M., Ghate, Z., Gherendi, M., Giacalone, M., Giacomelli, J. C., Gibson, L., Giegerich, C. S., Gil, T., Gil, C., Gilligan, L., Gin, S., Giovannozzi, D., Girardo, E., Giroud, J. B., Giruzzi, C., Gerardo, Glã¶ggler, Godwin, S., Goff, J., Gohil, J., Goloborod'Ko, P., Gomes, V., Goncalves, R., Goniche, B., Goodliffe, M., Goodyear, M., Gorini, A., Gosk, G., Goulding, M., Goussarov, R., Gowland, A., Graham, R., Graham, B., Graves, M. E., Grazier, J. P., Grazier, N., Green, P., Greuner, N. R., Grierson, H., Griph, B., Grisolia, F. S., Grist, C., Groth, D., Grove, M., Grundy, R., Grzonka, C. N., Guard, J., Guã©rard, D., Guillemaut, C., Guirlet, C., Gurl, R., Utoh, C., Hackett, H. H., Hacquin, L. J., Hagar, S., Hager, A., Hakola, R., Halitovs, A., Hall, M., S. J., Hallworth, Cook, S. P., Hamlyn, Harris, Hammond, C., Harrington, K., Harrison, C., Harting, J., Hasenbeck, D., Hatano, F., Hatch, Y., Haupt, D. R., Hawes, T. D. V., Hawkes, J., Hawkins, N. C., Hawkins, J., Haydon, P., Hayter, P. W., Hazel, N., Heesterman, S., Heinola, P. J. L., Hellesen, K., Hellsten, C., Helou, T., Hemming, W., Hender, O. N., Henderson, T. C., Henderson, M., Henriques, S. S., Hepple, R., Hermon, D., Hertout, G., Hidalgo, P., Highcock, C., Hill, E. G., Hillairet, M., Hillesheim, J., Hillis, J., Hizanidis, D., Hjalmarsson, K., Hobirk, A., Hodille, J., Hogben, E., Hogeweij, C. H. A., Hollingsworth, G. M. D., Hollis, A., Homfray, S., Horã¡äek, D. A., Hornung, J., Horton, G., Horton, A. R., Horvath, L. D., Hotchin, L., Hough, S. P., Howarth, M. R., Hubbard, P. J., Huber, A., Huddleston, V., Hughes, T. M., Huijsmans, M., Hunter, G. T. A., Huynh, C. L., Hynes, P., Iglesias, A. M., Imazawa, D., Imbeaux, N., Imrã¬å¡ek, F., Incelli, M., Innocente, M., Irishkin, P., Ivanova, Stanik, Jachmich, I., Jacobsen, S., Jacquet, A. S., Jansons, P., Jardin, J., Jã¤rvinen, A., Jaulmes, A., Jednorã³g, F., Jenkins, S., Jeong, I., Jepu, C., Joffrin, I., Johnson, E., Johnson, R., Johnston, T., Jane, Joita, Jones, L., Jones, G., Hoshino, T. T. C., Kallenbach, K. K., Kamiya, A., Kaniewski, K., Kantor, J., Kappatou, A., Karhunen, A., Karkinsky, J., Karnowska, D., Kaufman, I., Kaveney, M., Kazakov, G., Kazantzidis, Y., Keeling, V., Keenan, D. L., Keep, T., Kempenaars, J., Kennedy, M., Kenny, C., Kent, D., Kent, J., Khilkevich, O. N., Kim, E., Kim, H. T., Kinch, H. S., King, A., King, C., King, D., Kinna, R. F., Kiptily, D. J., Kirk, V., Kirov, A., Kirschner, K., Kizane, A., Klepper, G., Klix, C., Knight, A., Knipe, P., Knott, S. J., Kobuchi, S., Kã¶chl, T., Kocsis, F., Kodeli, G., Kogan, I., Kogut, L., Koivuranta, D., Kominis, S., Kã¶ppen, Y., Kos, M., Koskela, B., Koslowski, T., Koubiti, H. R., Kovari, M., Kowalska, Strzè©ciwilk, Krasilnikov, E., Krasilnikov, A., Krawczyk, V., Kresina, N., Krieger, M., Krivska, K., Kruezi, A., Ksiaå¼ek, U., Kukushkin, I., Kundu, A., Kurki, Suonio, Kwak, T., Kwiatkowski, S., Kwon, R., Laguardia, O. J., Lahtinen, L., Laing, A., Lam, A., Lambertz, N., Lane, H. T., Lang, C., Lanthaler, P. T., Lapins, S., Lasa, J., Last, A., Åaszyå„ska, J. R., Lawless, E., Lawson, R., Lawson, A., Lazaros, K. D., Lazzaro, A., Leddy, E., Lee, J., Lefebvre, S., Leggate, X., Lehmann, H. J., Lehnen, J., Leichtle, M., Leichuer, D., Leipold, P., Lengar, F., Lennholm, I., Lerche, M., Lescinskis, E., Lesnoj, A., Letellier, S., Leyland, E., Leysen, M., Li, W., Liang, L., Likonen, Y., Linke, J., Linsmeier, J., Lipschultz, C. h., Liu, B., Liu, G., Schiavo, Lo, Loarer, V. P., Loarte, T., Lobel, A., Lomanowski, R. C., Lomas, B., Lã¶nnroth, P. J., Lã³pez, J., J. M., Lã³pez, Razola, Lorenzini, J., Losada, R., Lovell, U., Loving, J. J., Lowry, A. B., Luce, C., Lucock, T., Lukin, R. M. A., Luna, A., Lungaroni, C., Lungu, M., Lungu, C. P., Lunniss, M., Lupelli, A., Lyssoivan, I., Macdonald, A., Macheta, N., Maczewa, P., Magesh, K., Maget, B., Maggi, P., Maier, C., Mailloux, H., Makkonen, J., Makwana, T., Malaquias, R., Malizia, A., Manas, A., Manning, P., Manso, A., Mantica, M. E., Mantsinen, P., Manzanares, M., Maquet, A., Marandet, P. h., Marcenko, Y., Marchetto, N., Marchuk, C., Marinelli, O., Marinucci, M., Markoviä, M., Marocco, T., Marot, D., Marren, L., Marshal, C. A., Martin, R., Martin, A., Martìn De Aguilera, Martã¬nez, A., F. J., Martã¬n, Solã¬s, Martynova, J. R., Maruyama, Y., Masiello, S., Maslov, A., Matejcik, M., Mattei, S., Matthews, M., Maviglia, G. F., Mayer, F., Mayoral, M., M. L., May, Smith, Mazon, T., Mazzotta, D., Mcadams, C., Mccarthy, R., Mcclements, P. J., Mccormack, K. G., Mccullen, O., Mcdonald, P. A., Mcintosh, D., Mckean, S., Mckehon, R., Meadows, J., Meakins, R. C., Medina, A., Medland, F., Medley, M., Meigh, S., Meigs, S., Meisl, A. G., Meitner, G., Meneses, S., Menmuir, L., Mergia, S., Merrigan, K., Mertens, I. R., Meshchaninov, P. h., Messiaen, S., Meyer, A., Mianowski, H., Michling, S., Middleton, Gear, Miettunen, D., Militello, J., Militello, Asp, Miloshevsky, E., Mink, G., Minucci, F., Miyoshi, S., Mlynã¡å™, Y., Molina, J., Monakhov, D., Moneti, I., Mooney, M., Moradi, R., Mordijck, S., Moreira, S., Moreno, L., Moro, R., Morris, F., Morris, A. W., Moser, J., Mosher, L., Moulton, S., Murari, D., Muraro, A., Murphy, A., Asakura, S., N. N., Na, Nabais, Y. S., Naish, F., Nakano, R., Nardon, T., Naulin, E., Nave, V., Nedzelski, M. F. F., Nemtsev, I., Nespoli, G., Neto, F., Neu, A., Neverov, R., Newman, V. S., Nicholls, M., Nicolas, K. J., Nielsen, T., Nielsen, A. H., Nilsson, P., Nishijima, E., Noble, D., Nocente, C., Nodwell, M., Nordlund, D., Nordman, K., Nouailletas, H., Nunes, R., Oberkofler, I., Odupitan, M., Ogawa, T., O'Gorman, M. T., Okabayashi, T., Olney, M., Omolayo, R., O'Mullane, O., Ongena, M., Orsitto, J., Orszagh, F., Oswuigwe, J., Otin, B. I., Owen, R., Paccagnella, A., Pace, R., Pacella, N., Packer, D., Page, L. W., Pajuste, A., Palazzo, E., Pamela, S., Panja, S., Papp, S., Paprok, P., Parail, R., Park, V., Parra, Diaz, Parsons, F., Pasqualotto, M., Patel, R., Pathak, A., Paton, S., Patten, D., Pau, H., Pawelec, A., Paz, Soldan, Peackoc, C., Pearson, A., Pehkonen, I. J., Peluso, S. P., Penot, E., Pereira, C., Pereira, A., Pereira, Puglia, P. P., Perez Von Thun, Peruzzo, C., Peschanyi, S., Peterka, S., Petersson, M., Petravich, P., Petre, G., Petrella, A., Petrå¾ilka, N., Peysson, V., Pfefferlã©, Y., Philipps, D., Pillon, V., Pintsuk, M., Piovesan, G., Pires Dos Reis, Piron, Lidia, Pironti, A., Pisano, F., Pitts, R., Pizzo, F., Plyusnin, V., Pomaro, N., Pompilian, O. G., Pool, P. J., Popovichev, S., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Powell, T., Pozzi, J., Prajapati, V., Prakash, R., Prestopino, G., Price, D., Price, M., Price, R., Prior, P., Proudfoot, R., Pucella, G., Puglia, P., Puiatti, M. E., Pulley, D., Purahoo, K., Pã¼tterich, T. h., Rachlew, E., Rack, M., Ragona, R., Rainford, M. S. J., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, J. J., Rathod, K., Rattã¡, G., Ratynskaia, S., Ravera, G., Rayner, C., Rebai, M., Reece, D., Reed, A., Rã©fy, D., Regan, B., Regaã±a, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes, Cortes, Reynolds, S. D. A., Riccardo, S., Richardson, V., Riddle, N., Rigamonti, K., Rimini, D., Risner, F. G., Riva, J., Roach, M., Robins, C., Robinson, R. J., Robinson, S. A., Robson, T., Roccella, D. W., Rodionov, R., Rodrigues, R., Rodriguez, P., Rohde, J., Romanelli, V., Romanelli, F., Romanelli, M., Romazanov, S., Rowe, J., Rubel, S., Rubinacci, M., Rubino, G., Ruchko, G., Ruiz, L., Ruset, M., Rzadkiewicz, C., Saarelma, J., Sabot, S., Safi, R., Sagar, E., Saibene, P., Saint, Laurent, Salewski, F., Salmi, M., Salmon, A., Salzedas, R., Samaddar, F., Samm, D., Sandiford, U., Santa, D., Santala, P., Santos, M. I. K., Santucci, B., Sartori, A., Sartori, F., Sauter, R., Scannell, O., Schlummer, R., Schmid, T., Schmidt, K., Schmuck, V., Schneider, S., Schã¶pf, M., Schwã¶rer, K., Scott, D., Sergienko, S. D., Sertoli, G., Shabbir, M., Sharapov, A., Shaw, S. E., Shaw, A., Sheikh, R., Shepherd, H., Shevelev, A., Shumack, A., Sias, A., Sibbald, G., Sieglin, M., Silburn, B., Silva, S., Silva, A., Simmons, C., Simpson, P. A., Simpson, Hutchinson, Sinha, J., Sipilã¤, A., Sips, S. K., Sirã©n, A. C. C., Sirinelli, P., Sjã¶strand, A., Skiba, H., Skilton, M., Slabkowska, R., Slade, K., Smith, B., Smith, N., Smith, P. G., Smith, R., Smithies, T. J., Snoj, M., Soare, L., Solano, S., Somers, E. R., Sommariva, A., Sonato, C., Piergiorgio, Sopplesa, Sousa, A., Sozzi, J., Spagnolo, C., Silvia, Spelzini, Spineanu, T., Stables, F., Stamatelatos, G., Stamp, I., Staniec, M. F., Stankå«nas, P., Stan, Sion, Stead, C., Stefanikova, M. J., Stepanov, E., Stephen, I., Stephen, A. V., Stevens, M., Stevens, A., Strachan, B. D., Strand, J., Strauss, P., Strã¶m, H. R., Stubbs, P., Studholme, G., Subba, W., Summers, F., Svensson, H. P., Åšwiderski, J., Szabolics, Å. ., Szawlowski, T., Szepesi, M., Suzuki, G., Tã¡l, T. T., Tala, B., Talbot, T., Talebzadeh, A. R., Taliercio, S., Cesare, Tamain, Tame, P., Tang, C., Tardocchi, W., Taroni, M., Taylor, L., Taylor, D., Tegnered, K. A., Telesca, D., Teplova, G., Terranova, N., David, Testa, Tholerus, D., Thomas, E., Thomas, J., Thomas, J. D., Thompson, P., Thompson, A., Thompson, C. A., Thorne, V. K., Thornton, L., Thrysã¸e, A., Tigwell, A. S., Tipton, P. A., Tiseanu, N., Tojo, I., Tokitani, H., Tolias, M., Tomeå¡, P., Tonner, M., Towndrow, P., Trimble, M., Tripsky, P., Tsalas, M., Tsavalas, M., Tskhakaya, Jun, Turner, D., Turner, I., Turnyanskiy, M. M., Tvalashvili, M., Tyrrell, G., Uccello, S. G. J., Abidin, Ul, Uljanovs, Z., Ulyatt, J., Urano, D., Uytdenhouwen, H., Vadgama, I., Valcarcel, A. P., Valentinuzzi, D., Valisa, M., Vallejos, Olivares, Valovic, P., Van De Mortel, Van, Eester, Van, Renterghem, Van, Rooij, Varje, G. J., Varoutis, J., Vartanian, S., Vasava, S., Vasilopoulou, K., Vega, T., Verdoolaege, J., Verhoeven, G., Verona, R., Verona, Rinati, Veshchev, G., Vianello, E., Vicente, N., Viezzer, J., Villari, E., Villone, S., Vincenzi, F., Pietro, Vinyar, Viola, I., Vitins, B., Vizvary, A., Vlad, Z., Voitsekhovitch, M., Vondrã¡äek, I., Vora, P., Vu, N., Pires De Sa, Wakeling, W. W., Waldon, B., Walkden, C. W. F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., I, and JET Contributors
- Subjects
Jet (fluid) ,Surface analysis ,Materials science ,Divertor ,JET-ILW ,Material deposition ,Material erosion ,Nuclear engineering ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,010305 fluids & plasmas ,13. Climate action ,Material Erosion ,0103 physical sciences ,Erosion ,010306 general physics ,Deposition (chemistry) ,Mathematical Physics - Abstract
Erosion of plasma-facing materials and successive transport and redeposition of eroded material are crucial processes determining the lifetime of plasma-facing components and the trapped tritium inventory in redeposited material layers. Erosion and deposition in the JET divertor were studied during the second JET ITER-like wall campaign ILW-2 in 2013-2014 by using a poloidal row of specially prepared divertor marker tiles including the tungsten bulk tile 5. The marker tiles were analyzed using elastic backscattering with 3-4.5 MeV incident protons and nuclear reaction analysis using 0.8-4.5 MeV 3He ions before and after the campaign. The erosion/deposition pattern observed during ILW-2 is qualitatively comparable to the first campaign ILW-1 in 2011-2012: deposits consist mainly of beryllium with 5-20 at.% of carbon and oxygen and small amounts of Ni and W. The highest deposition with deposited layer thicknesses up to 30 μm per campaign is still observed on the upper and horizontal parts of the inner divertor. Outer divertor tiles 5, 6, 7 and 8 are net W erosion areas. The observed D inventory is roughly comparable to the inventory observed during ILW-1. The results obtained during ILW-2 therefore confirm the positive results observed in ILW-1 with respect to reduced material deposition and hydrogen isotopes retention in the divertor.
- Published
- 2017
8. Overview of fuel inventory in JET with the ITER-like wall
- Author
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Widdowson, A., Coad, J. P., Alves, E., Baron-Wiechec, A., Barradas, N. P., Brezinsek, S., Catarino, N., Corregidor, V., Heinola, K., Koivuranta, S., Krat, S., Lahtinen, A., Likonen, J., Matthews, G. F., Mayer, M., Petersson, P., Litaudon, Rubel M., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. A., Barnes, D., Barnsley, M., Baron, Wiechec, Barrera, Orte, Baruzzo, L., Matteo, Basiuk, Bassan, V., Bastow, M., Batista, R., Batistoni, A., Baughan, P., Bauvir, R., Baylor, B., Bazylev, L., Beal, B., Beaumont, J., Beckers, P. S., Beckett, M., Becoulet, B., Bekris, A., Beldishevski, N., Bell, M., Belli, K., Bellinger, F., Belonohy, M., Ben, Ayed, Benterman, N., Bergsã¥ker, N. A., Bernardo, H., Bernert, J., Berry, M., Bertalot, M., Besliu, L., Beurskens, C., Bieg, M., Bielecki, B., Biewer, J., Bigi, T., Bã¬lkovã¡, M., Binda, P., Bisoffi, F., Bizarro, A., Bjã¶rkas, J. P. S., Blackburn, C., Blackman, J., Blackman, K., Blanchard, T. R., Blatchford, P., Bobkov, P., Boboc, V., Bodnã¡r, A., Bogar, G., Bolshakova, O., Bolzonella, I., Tommaso, Bonanomi, Bonelli, N., Boom, F., Booth, J., Borba, J., Borodin, D., Borodkina, D., Botrugno, I., Bottereau, A., Boulting, C., Bourdelle, P., Bowden, C., Bower, M., Bowman, C., Boyce, C., Boyd, T., Boyer, C., Bradshaw, H. J., Braic, J. M. A., Bravanec, V., Breizman, R., Bremond, B., Brennan, S., Breton, P. D., Brett, S., Brezinsek, A., Bright, S., Brix, M. D. J., Broeckx, M., Brombin, W., Matteo, Broså‚awski, Brown, A., Brown, D. P. D., Bruno, M., Bucalossi, E., Buch, J., Buchanan, J., Buckley, J., Budny, M. A., Bufferand, R., Bulman, H., Bulmer, M., Bunting, N., Buratti, P., Burckhart, P., Buscarino, A., Busse, A., Butler, A., Bykov, N. K., Byrne, I., Cahyna, J., Calabrã², P., Calvo, G., Camenen, I., Camp, Y., Campling, P., Cane, D. C., Cannas, J., Capel, B., Card, A. J., Cardinali, P. J., Carman, A., Carr, P., Carralero, M., Carraro, D., Carvalho, L., Carvalho, B. B., Carvalho, I., Casson, P., Castaldo, F. J., Catarino, C., Caumont, N., Causa, J., Cavazzana, F., Cave, Ayland, Cavinato, K., Cecconello, M., Ceccuzzi, M., Cecil, S., Cenedese, E., Angelo, Cesario, Challis, R., Chandler, C. D., Chandra, M., Chang, D., Chankin, C. S., Chapman, A., Chapman, I. T., Chernyshova, S. C., Chitarin, M., Giuseppe, Ciraolo, Ciric, G., Citrin, D., Clairet, J., Clark, F., Clark, E., Clarkson, M., Clatworthy, R., Clements, D., Cleverly, C., Coad, M., Coates, J. P., Cobalt, P. A., Coccorese, A., Cocilovo, V., Coda, V., Coelho, S., Coenen, R., Coffey, J. W., Colas, I., Collins, L., Conka, S., Conroy, D., Conway, S., Coombs, N., Cooper, D., Corradino, S. R., Corre, C., Corrigan, Y., Cortes, G., Coster, S., Couchman, D., Cox, A. S., Craciunescu, M. P., Cramp, T., Craven, S., Crisanti, R., Croci, F., Croft, G., Crombã©, D., Crowe, K., Cruz, R., Cseh, N., Cufar, G., Cullen, A., Curuia, A., Czarnecka, M., Dabirikhah, A., Dalgliesh, H., Dalley, P., Dankowski, S., Darrow, J., Davies, D., Davis, O., Day, W., Day, C., I. E., Bock, De, Castro, De, De La Cal, De La Luna, Masi, De, Pablos, De, J. L., Temmerman, De, Tommasi, De, Vries, De, Deakin, P., Deane, K., Degli, Agostini, Dejarnac, F., Delabie, R., Den, Harder, Dendy, N., Denis, R. O., Denner, J., Devaux, P., Devynck, S., Maio, Di, Siena, Di, Troia, Di, Dinca, C., D'Inca, P., Ding, R., Dittmar, B., Doerk, T., Doerner, H., Donnã©, R. P., Dorling, T., S. E., Dormido, Canto, Doswon, S., Douai, S., Doyle, D., Drenik, P. T., Drewelow, A., Drews, P., Duckworth, P., Dumont, P. h., Dumortier, R., Dunai, P., Dunne, D., Äžuran, M., Durodiã©, I., Dutta, F., Duval, P., Dux, B. P., Dylst, R., Dzysiuk, K., Edappala, N., Edmond, P. V., Edwards, J., Edwards, A. M., Eich, J., Ekedahl, T. h., Jorf, El, Elsmore, R., Enachescu, C. G., Ericsson, M., Eriksson, G., Eriksson, F., Eriksson, J., Esposito, L. G., Esquembri, B., Esser, S., Esteve, H. G., Evans, D., Evans, B., Evison, G. E., Ewart, G., Fagan, G. D., Faitsch, D., Falie, M., Fanni, D., Fasoli, A., Faustin, A., Fawlk, J. M., Fazendeiro, N., Fedorczak, L., Felton, N., Fenton, R. C., Fernades, K., Fernandes, A., Ferreira, H., Fessey, J., Fã©vrier, J. A., Ficker, O., Field, O., Fietz, A., Figueiredo, S., Figueiredo, A., Fil, J., Finburg, A., Firdaouss, P., Fischer, M., Fittill, U., Fitzgerald, L., Flammini, M., Flanagan, D., Fleming, J., Flinders, C., Fonnesu, K., Fontdecaba, N., Formisano, J. M., Forsythe, A., Fortuna, L., Fortuna, Zalesna, Fortune, E., Foster, M., Franke, S., Franklin, T., Frasca, T., Frassinetti, M., Freisinger, L., Fresa, M., Frigione, R., Fuchs, D., Fuller, V., Futatani, D., Fyvie, S., Gã¡l, J., Galassi, K., Gaå‚azka, D., Galdon, Quiroga, Gallagher, J., Gallart, J., Galvã¡o, D., Gao, R., Gao, X., Garcia, Y., Garcia, Carrasco, Garcã¬a, Muã±oz, Gardarein, M., Garzotti, J. L., Gaudio, L., Gauthier, P., Gear, E., Gee, D. F., Geiger, S. J., Gelfusa, B., Gerasimov, M., Gervasini, S., Gethins, G., Ghani, M., Ghate, Z., Gherendi, M., Giacalone, M., Giacomelli, J. C., Gibson, L., Giegerich, C. S., Gil, T., Gil, C., Gilligan, L., Gin, S., Giovannozzi, D., Girardo, E., Giroud, J. B., Giruzzi, C., Gerardo, Glã¶ggler, Godwin, S., Goff, J., Gohil, J., Goloborod'Ko, P., Gomes, V., Goncalves, R., Goniche, B., Goodliffe, M., Goodyear, M., Gorini, A., Gosk, G., Goulding, M., Goussarov, R., Gowland, A., Graham, R., Graham, B., Graves, M. E., Grazier, J. P., Grazier, N., Green, P., Greuner, N. R., Grierson, H., Griph, B., Grisolia, F. S., Grist, C., Groth, D., Grove, M., Grundy, R., Grzonka, C. N., Guard, J., Guã©rard, D., Guillemaut, C., Guirlet, C., Gurl, R., Utoh, C., Hackett, H. H., Hacquin, L. J., Hagar, S., Hager, A., Hakola, R., Halitovs, A., Hall, M., S. J., Hallworth, Cook, S. P., Hamlyn, Harris, Hammond, C., Harrington, K., Harrison, C., Harting, J., Hasenbeck, D., Hatano, F., Hatch, Y., Haupt, D. R., Hawes, T. D. V., Hawkes, J., Hawkins, N. C., Hawkins, J., Haydon, P., Hayter, P. W., Hazel, N., Heesterman, S., Heinola, P. J. L., Hellesen, K., Hellsten, C., Helou, T., Hemming, W., Hender, O. N., Henderson, T. C., Henderson, M., Henriques, S. S., Hepple, R., Hermon, D., Hertout, G., Hidalgo, P., Highcock, C., Hill, E. G., Hillairet, M., Hillesheim, J., Hillis, J., Hizanidis, D., Hjalmarsson, K., Hobirk, A., Hodille, J., Hogben, E., Hogeweij, C. H. A., Hollingsworth, G. M. D., Hollis, A., Homfray, S., Horã¡äek, D. A., Hornung, J., Horton, G., Horton, A. R., Horvath, L. D., Hotchin, L., Hough, S. P., Howarth, M. R., Hubbard, P. J., Huber, A., Huddleston, V., Hughes, T. M., Huijsmans, M., Hunter, G. T. A., Huynh, C. L., Hynes, P., Iglesias, A. M., Imazawa, D., Imbeaux, N., Imrã¬å¡ek, F., Incelli, M., Innocente, M., Irishkin, P., Ivanova, Stanik, Jachmich, I., Jacobsen, S., Jacquet, A. S., Jansons, P., Jardin, J., Jã¤rvinen, A., Jaulmes, A., Jednorã³g, F., Jenkins, S., Jeong, I., Jepu, C., Joffrin, I., Johnson, E., Johnson, R., Johnston, T., Jane, Joita, Jones, L., Jones, G., Hoshino, T. T. C., Kallenbach, K. K., Kamiya, A., Kaniewski, K., Kantor, J., Kappatou, A., Karhunen, A., Karkinsky, J., Karnowska, D., Kaufman, I., Kaveney, M., Kazakov, G., Kazantzidis, Y., Keeling, V., Keenan, D. L., Keep, T., Kempenaars, J., Kennedy, M., Kenny, C., Kent, D., Kent, J., Khilkevich, O. N., Kim, E., Kim, H. T., Kinch, H. S., King, A., King, C., King, D., Kinna, R. F., Kiptily, D. J., Kirk, V., Kirov, A., Kirschner, K., Kizane, A., Klepper, G., Klix, C., Knight, A., Knipe, P., Knott, S. J., Kobuchi, S., Kã¶chl, T., Kocsis, F., Kodeli, G., Kogan, I., Kogut, L., Koivuranta, D., Kominis, S., Kã¶ppen, Y., Kos, M., Koskela, B., Koslowski, T., Koubiti, H. R., Kovari, M., Kowalska, Strzè©ciwilk, Krasilnikov, E., Krasilnikov, A., Krawczyk, V., Kresina, N., Krieger, M., Krivska, K., Kruezi, A., Ksiaå¼ek, U., Kukushkin, I., Kundu, A., Kurki, Suonio, Kwak, T., Kwiatkowski, S., Kwon, R., Laguardia, O. J., Lahtinen, L., Laing, A., Lam, A., Lambertz, N., Lane, H. T., Lang, C., Lanthaler, P. T., Lapins, S., Lasa, J., Last, A., Åaszyå„ska, J. R., Lawless, E., Lawson, R., Lawson, A., Lazaros, K. D., Lazzaro, A., Leddy, E., Lee, J., Lefebvre, S., Leggate, X., Lehmann, H. J., Lehnen, J., Leichtle, M., Leichuer, D., Leipold, P., Lengar, F., Lennholm, I., Lerche, M., Lescinskis, E., Lesnoj, A., Letellier, S., Leyland, E., Leysen, M., Li, W., Liang, L., Likonen, Y., Linke, J., Linsmeier, J., Lipschultz, C. h., Liu, B., Liu, G., Schiavo, Lo, Loarer, V. P., Loarte, T., Lobel, A., Lomanowski, R. C., Lomas, B., Lã¶nnroth, P. J., Lã³pez, J., J. M., Lã³pez, Razola, Lorenzini, J., Losada, R., Lovell, U., Loving, J. J., Lowry, A. B., Luce, C., Lucock, T., Lukin, R. M. A., Luna, A., Lungaroni, C., Lungu, M., Lungu, C. P., Lunniss, M., Lupelli, A., Lyssoivan, I., Macdonald, A., Macheta, N., Maczewa, P., Magesh, K., Maget, B., Maggi, P., Maier, C., Mailloux, H., Makkonen, J., Makwana, T., Malaquias, R., Malizia, A., Manas, A., Manning, P., Manso, A., Mantica, M. E., Mantsinen, P., Manzanares, M., Maquet, A., Marandet, P. h., Marcenko, Y., Marchetto, N., Marchuk, C., Marinelli, O., Marinucci, M., Markoviä, M., Marocco, T., Marot, D., Marren, L., Marshal, C. A., Martin, R., Martin, A., Martìn De Aguilera, Martã¬nez, A., F. J., Martã¬n, Solã¬s, Martynova, J. R., Maruyama, Y., Masiello, S., Maslov, A., Matejcik, M., Mattei, S., Matthews, M., Maviglia, G. F., Mayer, F., Mayoral, M., M. L., May, Smith, Mazon, T., Mazzotta, D., Mcadams, C., Mccarthy, R., Mcclements, P. J., Mccormack, K. G., Mccullen, O., Mcdonald, P. A., Mcintosh, D., Mckean, S., Mckehon, R., Meadows, J., Meakins, R. C., Medina, A., Medland, F., Medley, M., Meigh, S., Meigs, S., Meisl, A. G., Meitner, G., Meneses, S., Menmuir, L., Mergia, S., Merrigan, K., Mertens, I. R., Meshchaninov, P. h., Messiaen, S., Meyer, A., Mianowski, H., Michling, S., Middleton, Gear, Miettunen, D., Militello, J., Militello, Asp, Miloshevsky, E., Mink, G., Minucci, F., Miyoshi, S., Mlynã¡å™, Y., Molina, J., Monakhov, D., Moneti, I., Mooney, M., Moradi, R., Mordijck, S., Moreira, S., Moreno, L., Moro, R., Morris, F., Morris, A. W., Moser, J., Mosher, L., Moulton, S., Murari, D., Muraro, A., Murphy, A., Asakura, S., N. N., Na, Nabais, Y. S., Naish, F., Nakano, R., Nardon, T., Naulin, E., Nave, V., Nedzelski, M. F. F., Nemtsev, I., Nespoli, G., Neto, F., Neu, A., Neverov, R., Newman, V. S., Nicholls, M., Nicolas, K. J., Nielsen, T., Nielsen, A. H., Nilsson, P., Nishijima, E., Noble, D., Nocente, C., Nodwell, M., Nordlund, D., Nordman, K., Nouailletas, H., Nunes, R., Oberkofler, I., Odupitan, M., Ogawa, T., O'Gorman, M. T., Okabayashi, T., Olney, M., Omolayo, R., O'Mullane, O., Ongena, M., Orsitto, J., Orszagh, F., Oswuigwe, J., Otin, B. I., Owen, R., Paccagnella, A., Pace, R., Pacella, N., Packer, D., Page, L. W., Pajuste, A., Palazzo, E., Pamela, S., Panja, S., Papp, S., Paprok, P., Parail, R., Park, V., Parra, Diaz, Parsons, F., Pasqualotto, M., Patel, R., Pathak, A., Paton, S., Patten, D., Pau, H., Pawelec, A., Paz, Soldan, Peackoc, C., Pearson, A., Pehkonen, I. J., Peluso, S. P., Penot, E., Pereira, C., Pereira, A., Pereira, Puglia, P. P., Perez Von Thun, Peruzzo, C., Peschanyi, S., Peterka, S., Petersson, M., Petravich, P., Petre, G., Petrella, A., Petrå¾ilka, N., Peysson, V., Pfefferlã©, Y., Philipps, D., Pillon, V., Pintsuk, M., Piovesan, G., Pires Dos Reis, Piron, Lidia, Pironti, A., Pisano, F., Pitts, R., Pizzo, F., Plyusnin, V., Pomaro, N., Pompilian, O. G., Pool, P. J., Popovichev, S., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Powell, T., Pozzi, J., Prajapati, V., Prakash, R., Prestopino, G., Price, D., Price, M., Price, R., Prior, P., Proudfoot, R., Pucella, G., Puglia, P., Puiatti, M. E., Pulley, D., Purahoo, K., Pã¼tterich, T. h., Rachlew, E., Rack, M., Ragona, R., Rainford, M. S. J., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, J. J., Rathod, K., Rattã¡, G., Ratynskaia, S., Ravera, G., Rayner, C., Rebai, M., Reece, D., Reed, A., Rã©fy, D., Regan, B., Regaã±a, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes, Cortes, Reynolds, S. D. A., Riccardo, S., Richardson, V., Riddle, N., Rigamonti, K., Rimini, D., Risner, F. G., Riva, J., Roach, M., Robins, C., Robinson, R. J., Robinson, S. A., Robson, T., Roccella, D. W., Rodionov, R., Rodrigues, R., Rodriguez, P., Rohde, J., Romanelli, V., Romanelli, F., Romanelli, M., Romazanov, S., Rowe, J., Rubel, S., Rubinacci, M., Rubino, G., Ruchko, G., Ruiz, L., Ruset, M., Rzadkiewicz, C., Saarelma, J., Sabot, S., Safi, R., Sagar, E., Saibene, P., Saint, Laurent, Salewski, F., Salmi, M., Salmon, A., Salzedas, R., Samaddar, F., Samm, D., Sandiford, U., Santa, D., Santala, P., Santos, M. I. K., Santucci, B., Sartori, A., Sartori, F., Sauter, R., Scannell, O., Schlummer, R., Schmid, T., Schmidt, K., Schmuck, V., Schneider, S., Schã¶pf, M., Schwã¶rer, K., Scott, D., Sergienko, S. D., Sertoli, G., Shabbir, M., Sharapov, A., Shaw, S. E., Shaw, A., Sheikh, R., Shepherd, H., Shevelev, A., Shumack, A., Sias, A., Sibbald, G., Sieglin, M., Silburn, B., Silva, S., Silva, A., Simmons, C., Simpson, P. A., Simpson, Hutchinson, Sinha, J., Sipilã¤, A., Sips, S. K., Sirã©n, A. C. C., Sirinelli, P., Sjã¶strand, A., Skiba, H., Skilton, M., Slabkowska, R., Slade, K., Smith, B., Smith, N., Smith, P. G., Smith, R., Smithies, T. J., Snoj, M., Soare, L., Solano, S., Somers, E. R., Sommariva, A., Sonato, C., Piergiorgio, Sopplesa, Sousa, A., Sozzi, J., Spagnolo, C., Silvia, Spelzini, Spineanu, T., Stables, F., Stamatelatos, G., Stamp, I., Staniec, M. F., Stankå«nas, P., Stan, Sion, Stead, C., Stefanikova, M. J., Stepanov, E., Stephen, I., Stephen, A. V., Stevens, M., Stevens, A., Strachan, B. D., Strand, J., Strauss, P., Strã¶m, H. R., Stubbs, P., Studholme, G., Subba, W., Summers, F., Svensson, H. P., Åšwiderski, J., Szabolics, Å. ., Szawlowski, T., Szepesi, M., Suzuki, G., Tã¡l, T. T., Tala, B., Talbot, T., Talebzadeh, A. R., Taliercio, S., Cesare, Tamain, Tame, P., Tang, C., Tardocchi, W., Taroni, M., Taylor, L., Taylor, D., Tegnered, K. A., Telesca, D., Teplova, G., Terranova, N., David, Testa, Tholerus, D., Thomas, E., Thomas, J., Thomas, J. D., Thompson, P., Thompson, A., Thompson, C. A., Thorne, V. K., Thornton, L., Thrysã¸e, A., Tigwell, A. S., Tipton, P. A., Tiseanu, N., Tojo, I., Tokitani, H., Tolias, M., Tomeå¡, P., Tonner, M., Towndrow, P., Trimble, M., Tripsky, P., Tsalas, M., Tsavalas, M., Tskhakaya, Jun, Turner, D., Turner, I., Turnyanskiy, M. M., Tvalashvili, M., Tyrrell, G., Uccello, S. G. J., Abidin, Ul, Uljanovs, Z., Ulyatt, J., Urano, D., Uytdenhouwen, H., Vadgama, I., Valcarcel, A. P., Valentinuzzi, D., Valisa, M., Vallejos, Olivares, Valovic, P., Van De Mortel, Van, Eester, Van, Renterghem, Van, Rooij, Varje, G. J., Varoutis, J., Vartanian, S., Vasava, S., Vasilopoulou, K., Vega, T., Verdoolaege, J., Verhoeven, G., Verona, R., Verona, Rinati, Veshchev, G., Vianello, E., Vicente, N., Viezzer, J., Villari, E., Villone, S., Vincenzi, F., Pietro, Vinyar, Viola, I., Vitins, B., Vizvary, A., Vlad, Z., Voitsekhovitch, M., Vondrã¡äek, I., Vora, P., Vu, N., Pires De Sa, Wakeling, W. W., Waldon, B., Walkden, C. W. F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., I, and JET Contributors
- Subjects
Nuclear and High Energy Physics ,Jet (fluid) ,Hydrogen ,Plasma parameters ,JET ITER-like wall ,Divertor ,Nuclear engineering ,chemistry.chemical_element ,Condensed Matter Physics ,01 natural sciences ,fuel retention ,010305 fluids & plasmas ,material migration ,chemistry ,Sputtering ,visual_art ,0103 physical sciences ,visual_art.visual_art_medium ,Environmental science ,Tile ,010306 general physics - Abstract
Post mortem analyses of JET ITER-Like-Wall tiles and passive diagnostics have been completed after each of the first two campaigns (ILW-1 and ILW-2). They show that the global fuel inventory is still dominated by co-deposition; hence plasma parameters and sputtering processes affecting material migration influence the distribution of retained fuel. In particular, differences between results from the two campaigns may be attributed to a greater proportion of pulses run with strike points in the divertor corners, and having about 300 discharges in hydrogen at the end of ILW-2. Recessed and remote areas can contribute to fuel retention due to the larger areas involved, e.g. recessed main chamber walls, gaps in castellated Be main chamber tiles and material migration to remote divertor areas. The fuel retention and material migration due to the bulk W Tile 5 during ILW-1 are presented. Overall these tiles account for only a small percentage of the global accountancy for ILW-1.
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- 2017
9. MeV-range velocity-space tomography from gamma-ray and neutron emission spectrometry measurements at JET
- Author
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Salewski, M., Nocente, M., Jacobsen, A. S., Binda, F., Cazzaniga, C., Ericsson, G., Eriksson, J., Gorini, G., Hellesen, C., Hjalmarsson, A., Kiptily, V. G., Koskela, T., Korsholm, S. B., Kurki-Suonio, T., Leipold, F., Madsen, J., Moseev, D., Nielsen, S. K., Rasmussen, J., Schneider, M., Sharapov, S. E., Stejner, M., Litaudon, Tardocchi M., Abduallev, X., Abhangi, S., Abreu, M., Afzal, P., Aggarwal, M., Ahlgren, K. M., Ahn, T., J. H., Aho, Mantila, Aiba, L., Airila, N., Albanese, M., Aldred, R., Alegre, V., Alessi, D., Aleynikov, E., Alfier, P., Alberto, Alkseev, Allinson, A., Alper, M., Alves, B., Ambrosino, E., Ambrosino, G., Amicucci, R., Amosov, L., Andersson, Sundã©n, Angelone, E., Anghel, M., Angioni, M., Appel, C., Appelbee, L., Arena, C., Ariola, P., Arnichand, M., Arshad, H., Ash, S., Ashikawa, A., Aslanyan, N., Asunta, V., Auriemma, O., Fulvio, Austin, Avotina, Y., Axton, L., Ayres, M. D., Bacharis, C., Baciero, M., Baiã¡o, A., Bailey, D., Baker, S., Balboa, A., Balden, I., Balshaw, M., Bament, N., Banks, R., Baranov, J. W., Barnard, Y. F., Barnes, M. A., Barnes, D., Barnsley, M., Baron, Wiechec, Barrera, Orte, Baruzzo, L., Matteo, Basiuk, Bassan, V., Bastow, M., Batista, R., Batistoni, A., Baughan, P., Bauvir, R., Baylor, B., Bazylev, L., Beal, B., Beaumont, J., Beckers, P. S., Beckett, M., Becoulet, B., Bekris, A., Beldishevski, N., Bell, M., Belli, K., Bellinger, F., Belonohy, M., Ben, Ayed, Benterman, N., Bergsã¥ker, N. A., Bernardo, H., Bernert, J., Berry, M., Bertalot, M., Besliu, L., Beurskens, C., Bieg, M., Bielecki, B., Biewer, J., Bigi, T., Bã¬lkovã¡, M., Binda, P., Bisoffi, F., Bizarro, A., Bjã¶rkas, J. P. S., Blackburn, C., Blackman, J., Blackman, K., Blanchard, T. R., Blatchford, P., Bobkov, P., Boboc, V., Bodnã¡r, A., Bogar, G., Bolshakova, O., Bolzonella, I., Tommaso, Bonanomi, Bonelli, N., Boom, F., Booth, J., Borba, J., Borodin, D., Borodkina, D., Botrugno, I., Bottereau, A., Boulting, C., Bourdelle, P., Bowden, C., Bower, M., Bowman, C., Boyce, C., Boyd, T., Boyer, C., Bradshaw, H. J., Braic, J. M. A., Bravanec, V., Breizman, R., Bremond, B., Brennan, S., Breton, P. D., Brett, S., Brezinsek, A., Bright, S., Brix, M. D. J., Broeckx, M., Brombin, W., Matteo, Broså‚awski, Brown, A., Brown, D. P. D., Bruno, M., Bucalossi, E., Buch, J., Buchanan, J., Buckley, J., Budny, M. A., Bufferand, R., Bulman, H., Bulmer, M., Bunting, N., Buratti, P., Burckhart, P., Buscarino, A., Busse, A., Butler, A., Bykov, N. K., Byrne, I., Cahyna, J., Calabrã², P., Calvo, G., Camenen, I., Camp, Y., Campling, P., Cane, D. C., Cannas, J., Capel, B., Card, A. J., Cardinali, P. J., Carman, A., Carr, P., Carralero, M., Carraro, D., Carvalho, L., Carvalho, B. B., Carvalho, I., Casson, P., Castaldo, F. J., Catarino, C., Caumont, N., Causa, J., Cavazzana, F., Cave, Ayland, Cavinato, K., Cecconello, M., Ceccuzzi, M., Cecil, S., Cenedese, E., Angelo, Cesario, Challis, R., Chandler, C. D., Chandra, M., Chang, D., Chankin, C. S., Chapman, A., Chapman, I. T., Chernyshova, S. C., Chitarin, M., Giuseppe, Ciraolo, Ciric, G., Citrin, D., Clairet, J., Clark, F., Clark, E., Clarkson, M., Clatworthy, R., Clements, D., Cleverly, C., Coad, M., Coates, J. P., Cobalt, P. A., Coccorese, A., Cocilovo, V., Coda, V., Coelho, S., Coenen, R., Coffey, J. W., Colas, I., Collins, L., Conka, S., Conroy, D., Conway, S., Coombs, N., Cooper, D., Corradino, S. R., Corre, C., Corrigan, Y., Cortes, G., Coster, S., Couchman, D., Cox, A. S., Craciunescu, M. P., Cramp, T., Craven, S., Crisanti, R., Croci, F., Croft, G., Crombã©, D., Crowe, K., Cruz, R., Cseh, N., Cufar, G., Cullen, A., Curuia, A., Czarnecka, M., Dabirikhah, A., Dalgliesh, H., Dalley, P., Dankowski, S., Darrow, J., Davies, D., Davis, O., Day, W., Day, C., I. E., Bock, De, Castro, De, De La Cal, De La Luna, Masi, De, Pablos, De, J. L., Temmerman, De, Tommasi, De, Vries, De, Deakin, P., Deane, K., Degli, Agostini, Dejarnac, F., Delabie, R., Den, Harder, Dendy, N., Denis, R. O., Denner, J., Devaux, P., Devynck, S., Maio, Di, Siena, Di, Troia, Di, Dinca, C., D'Inca, P., Ding, R., Dittmar, B., Doerk, T., Doerner, H., Donnã©, R. P., Dorling, T., S. E., Dormido, Canto, Doswon, S., Douai, S., Doyle, D., Drenik, P. T., Drewelow, A., Drews, P., Duckworth, P., Dumont, P. h., Dumortier, R., Dunai, P., Dunne, D., Äžuran, M., Durodiã©, I., Dutta, F., Duval, P., Dux, B. P., Dylst, R., Dzysiuk, K., Edappala, N., Edmond, P. V., Edwards, J., Edwards, A. M., Eich, J., Ekedahl, T. h., Jorf, El, Elsmore, R., Enachescu, C. G., Ericsson, M., Eriksson, G., Eriksson, F., Esposito, L. G., Esquembri, B., Esser, S., Esteve, H. G., Evans, D., Evans, B., Evison, G. E., Ewart, G., Fagan, G. D., Faitsch, D., Falie, M., Fanni, D., Fasoli, A., Faustin, A., Fawlk, J. M., Fazendeiro, N., Fedorczak, L., Felton, N., Fenton, R. C., Fernades, K., Fernandes, A., Ferreira, H., Fessey, J., Fã©vrier, J. A., Ficker, O., Field, O., Fietz, A., Figueiredo, S., Figueiredo, A., Fil, J., Finburg, A., Firdaouss, P., Fischer, M., Fittill, U., Fitzgerald, L., Flammini, M., Flanagan, D., Fleming, J., Flinders, C., Fonnesu, K., Fontdecaba, N., Formisano, J. M., Forsythe, A., Fortuna, L., Fortuna, Zalesna, Fortune, E., Foster, M., Franke, S., Franklin, T., Frasca, T., Frassinetti, M., Freisinger, L., Fresa, M., Frigione, R., Fuchs, D., Fuller, V., Futatani, D., Fyvie, S., Gã¡l, J., Galassi, K., Gaå‚azka, D., Galdon, Quiroga, Gallagher, J., Gallart, J., Galvã¡o, D., Gao, R., Gao, X., Garcia, Y., Garcia, Carrasco, Garcã¬a, Muã±oz, Gardarein, M., Garzotti, J. L., Gaudio, L., Gauthier, P., Gear, E., Gee, D. F., Geiger, S. J., Gelfusa, B., Gerasimov, M., Gervasini, S., Gethins, G., Ghani, M., Ghate, Z., Gherendi, M., Giacalone, M., Giacomelli, J. C., Gibson, L., Giegerich, C. S., Gil, T., Gil, C., Gilligan, L., Gin, S., Giovannozzi, D., Girardo, E., Giroud, J. B., Giruzzi, C., Gerardo, Glã¶ggler, Godwin, S., Goff, J., Gohil, J., Goloborod'Ko, P., Gomes, V., Goncalves, R., Goniche, B., Goodliffe, M., Goodyear, M., Gorini, A., Gosk, G., Goulding, M., Goussarov, R., Gowland, A., Graham, R., Graham, B., Graves, M. E., Grazier, J. P., Grazier, N., Green, P., Greuner, N. R., Grierson, H., Griph, B., Grisolia, F. S., Grist, C., Groth, D., Grove, M., Grundy, R., Grzonka, C. N., Guard, J., Guã©rard, D., Guillemaut, C., Guirlet, C., Gurl, R., Utoh, C., Hackett, H. H., Hacquin, L. J., Hagar, S., Hager, A., Hakola, R., Halitovs, A., Hall, M., S. J., Hallworth, Cook, S. P., Hamlyn, Harris, Hammond, C., Harrington, K., Harrison, C., Harting, J., Hasenbeck, D., Hatano, F., Hatch, Y., Haupt, D. R., Hawes, T. D. V., Hawkes, J., Hawkins, N. C., Hawkins, J., Haydon, P., Hayter, P. W., Hazel, N., Heesterman, S., Heinola, P. J. L., Hellesen, K., Hellsten, C., Helou, T., Hemming, W., Hender, O. N., Henderson, T. C., Henderson, M., Henriques, S. S., Hepple, R., Hermon, D., Hertout, G., Hidalgo, P., Highcock, C., Hill, E. G., Hillairet, M., Hillesheim, J., Hillis, J., Hizanidis, D., Hjalmarsson, K., Hobirk, A., Hodille, J., Hogben, E., Hogeweij, C. H. A., Hollingsworth, G. M. D., Hollis, A., Homfray, S., Horã¡äek, D. A., Hornung, J., Horton, G., Horton, A. R., Horvath, L. D., Hotchin, L., Hough, S. P., Howarth, M. R., Hubbard, P. J., Huber, A., Huddleston, V., Hughes, T. M., Huijsmans, M., Hunter, G. T. A., Huynh, C. L., Hynes, P., Iglesias, A. M., Imazawa, D., Imbeaux, N., Imrã¬å¡ek, F., Incelli, M., Innocente, M., Irishkin, P., Ivanova, Stanik, Jachmich, I., Jacobsen, S., Jacquet, A. S., Jansons, P., Jardin, J., Jã¤rvinen, A., Jaulmes, A., Jednorã³g, F., Jenkins, S., Jeong, I., Jepu, C., Joffrin, I., Johnson, E., Johnson, R., Johnston, T., Jane, Joita, Jones, L., Jones, G., Hoshino, T. T. C., Kallenbach, K. K., Kamiya, A., Kaniewski, K., Kantor, J., Kappatou, A., Karhunen, A., Karkinsky, J., Karnowska, D., Kaufman, I., Kaveney, M., Kazakov, G., Kazantzidis, Y., Keeling, V., Keenan, D. L., Keep, T., Kempenaars, J., Kennedy, M., Kenny, C., Kent, D., Kent, J., Khilkevich, O. N., Kim, E., Kim, H. T., Kinch, H. S., King, A., King, C., King, D., Kinna, R. F., Kiptily, D. J., Kirk, V., Kirov, A., Kirschner, K., Kizane, A., Klepper, G., Klix, C., Knight, A., Knipe, P., Knott, S. J., Kobuchi, S., Kã¶chl, T., Kocsis, F., Kodeli, G., Kogan, I., Kogut, L., Koivuranta, D., Kominis, S., Kã¶ppen, Y., Kos, M., Koskela, B., Koslowski, T., Koubiti, H. R., Kovari, M., Kowalska, Strzè©ciwilk, Krasilnikov, E., Krasilnikov, A., Krawczyk, V., Kresina, N., Krieger, M., Krivska, K., Kruezi, A., Ksiaå¼ek, U., Kukushkin, I., Kundu, A., Kurki, Suonio, Kwak, T., Kwiatkowski, S., Kwon, R., Laguardia, O. J., Lahtinen, L., Laing, A., Lam, A., Lambertz, N., Lane, H. T., Lang, C., Lanthaler, P. T., Lapins, S., Lasa, J., Last, A., Åaszyå„ska, J. R., Lawless, E., Lawson, R., Lawson, A., Lazaros, K. D., Lazzaro, A., Leddy, E., Lee, J., Lefebvre, S., Leggate, X., Lehmann, H. J., Lehnen, J., Leichtle, M., Leichuer, D., Leipold, P., Lengar, F., Lennholm, I., Lerche, M., Lescinskis, E., Lesnoj, A., Letellier, S., Leyland, E., Leysen, M., Li, W., Liang, L., Likonen, Y., Linke, J., Linsmeier, J., Lipschultz, C. h., Liu, B., Liu, G., Schiavo, Lo, Loarer, V. P., Loarte, T., Lobel, A., Lomanowski, R. C., Lomas, B., Lã¶nnroth, P. J., Lã³pez, J., J. M., Lã³pez, Razola, Lorenzini, J., Losada, R., Lovell, U., Loving, J. J., Lowry, A. B., Luce, C., Lucock, T., Lukin, R. M. A., Luna, A., Lungaroni, C., Lungu, M., Lungu, C. P., Lunniss, M., Lupelli, A., Lyssoivan, I., Macdonald, A., Macheta, N., Maczewa, P., Magesh, K., Maget, B., Maggi, P., Maier, C., Mailloux, H., Makkonen, J., Makwana, T., Malaquias, R., Malizia, A., Manas, A., Manning, P., Manso, A., Mantica, M. E., Mantsinen, P., Manzanares, M., Maquet, A., Marandet, P. h., Marcenko, Y., Marchetto, N., Marchuk, C., Marinelli, O., Marinucci, M., Markoviä, M., Marocco, T., Marot, D., Marren, L., Marshal, C. A., Martin, R., Martin, A., Martìn De Aguilera, Martã¬nez, A., F. J., Martã¬n, Solã¬s, Martynova, J. R., Maruyama, Y., Masiello, S., Maslov, A., Matejcik, M., Mattei, S., Matthews, M., Maviglia, G. F., Mayer, F., Mayoral, M., M. L., May, Smith, Mazon, T., Mazzotta, D., Mcadams, C., Mccarthy, R., Mcclements, P. J., Mccormack, K. G., Mccullen, O., Mcdonald, P. A., Mcintosh, D., Mckean, S., Mckehon, R., Meadows, J., Meakins, R. C., Medina, A., Medland, F., Medley, M., Meigh, S., Meigs, S., Meisl, A. G., Meitner, G., Meneses, S., Menmuir, L., Mergia, S., Merrigan, K., Mertens, I. R., Meshchaninov, P. h., Messiaen, S., Meyer, A., Mianowski, H., Michling, S., Middleton, Gear, Miettunen, D., Militello, J., Militello, Asp, Miloshevsky, E., Mink, G., Minucci, F., Miyoshi, S., Mlynã¡å™, Y., Molina, J., Monakhov, D., Moneti, I., Mooney, M., Moradi, R., Mordijck, S., Moreira, S., Moreno, L., Moro, R., Morris, F., Morris, A. W., Moser, J., Mosher, L., Moulton, S., Murari, D., Muraro, A., Murphy, A., Asakura, S., N. N., Na, Nabais, Y. S., Naish, F., Nakano, R., Nardon, T., Naulin, E., Nave, V., Nedzelski, M. F. F., Nemtsev, I., Nespoli, G., Neto, F., Neu, A., Neverov, R., Newman, V. S., Nicholls, M., Nicolas, K. J., Nielsen, T., Nielsen, A. H., Nilsson, P., Nishijima, E., Noble, D., Nocente, C., Nodwell, M., Nordlund, D., Nordman, K., Nouailletas, H., Nunes, R., Oberkofler, I., Odupitan, M., Ogawa, T., O'Gorman, M. T., Okabayashi, T., Olney, M., Omolayo, R., O'Mullane, O., Ongena, M., Orsitto, J., Orszagh, F., Oswuigwe, J., Otin, B. I., Owen, R., Paccagnella, A., Pace, R., Pacella, N., Packer, D., Page, L. W., Pajuste, A., Palazzo, E., Pamela, S., Panja, S., Papp, S., Paprok, P., Parail, R., Park, V., Parra, Diaz, Parsons, F., Pasqualotto, M., Patel, R., Pathak, A., Paton, S., Patten, D., Pau, H., Pawelec, A., Paz, Soldan, Peackoc, C., Pearson, A., Pehkonen, I. J., Peluso, S. P., Penot, E., Pereira, C., Pereira, A., Pereira, Puglia, P. P., Perez Von Thun, Peruzzo, C., Peschanyi, S., Peterka, S., Petersson, M., Petravich, P., Petre, G., Petrella, A., Petrå¾ilka, N., Peysson, V., Pfefferlã©, Y., Philipps, D., Pillon, V., Pintsuk, M., Piovesan, G., Pires Dos Reis, Piron, Lidia, Pironti, A., Pisano, F., Pitts, R., Pizzo, F., Plyusnin, V., Pomaro, N., Pompilian, O. G., Pool, P. J., Popovichev, S., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Powell, T., Pozzi, J., Prajapati, V., Prakash, R., Prestopino, G., Price, D., Price, M., Price, R., Prior, P., Proudfoot, R., Pucella, G., Puglia, P., Puiatti, M. E., Pulley, D., Purahoo, K., Pã¼tterich, T. h., Rachlew, E., Rack, M., Ragona, R., Rainford, M. S. J., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, J. J., Rathod, K., Rattã¡, G., Ratynskaia, S., Ravera, G., Rayner, C., Rebai, M., Reece, D., Reed, A., Rã©fy, D., Regan, B., Regaã±a, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes, Cortes, Reynolds, S. D. A., Riccardo, S., Richardson, V., Riddle, N., Rigamonti, K., Rimini, D., Risner, F. G., Riva, J., Roach, M., Robins, C., Robinson, R. J., Robinson, S. A., Robson, T., Roccella, D. W., Rodionov, R., Rodrigues, R., Rodriguez, P., Rohde, J., Romanelli, V., Romanelli, F., Romanelli, M., Romazanov, S., Rowe, J., Rubel, S., Rubinacci, M., Rubino, G., Ruchko, G., Ruiz, L., Ruset, M., Rzadkiewicz, C., Saarelma, J., Sabot, S., Safi, R., Sagar, E., Saibene, P., Saint, Laurent, Salewski, F., Salmi, M., Salmon, A., Salzedas, R., Samaddar, F., Samm, D., Sandiford, U., Santa, D., Santala, P., Santos, M. I. K., Santucci, B., Sartori, A., Sartori, F., Sauter, R., Scannell, O., Schlummer, R., Schmid, T., Schmidt, K., Schmuck, V., Schneider, S., Schã¶pf, M., Schwã¶rer, K., Scott, D., Sergienko, S. D., Sertoli, G., Shabbir, M., Sharapov, A., Shaw, S. E., Shaw, A., Sheikh, R., Shepherd, H., Shevelev, A., Shumack, A., Sias, A., Sibbald, G., Sieglin, M., Silburn, B., Silva, S., Silva, A., Simmons, C., Simpson, P. A., Simpson, Hutchinson, Sinha, J., Sipilã¤, A., Sips, S. K., Sirã©n, A. C. C., Sirinelli, P., Sjã¶strand, A., Skiba, H., Skilton, M., Slabkowska, R., Slade, K., Smith, B., Smith, N., Smith, P. G., Smith, R., Smithies, T. J., Snoj, M., Soare, L., Solano, S., Somers, E. R., Sommariva, A., Sonato, C., Piergiorgio, Sopplesa, Sousa, A., Sozzi, J., Spagnolo, C., Silvia, Spelzini, Spineanu, T., Stables, F., Stamatelatos, G., Stamp, I., Staniec, M. F., Stankå«nas, P., Stan, Sion, Stead, C., Stefanikova, M. J., Stepanov, E., Stephen, I., Stephen, A. V., Stevens, M., Stevens, A., Strachan, B. D., Strand, J., Strauss, P., Strã¶m, H. R., Stubbs, P., Studholme, G., Subba, W., Summers, F., Svensson, H. P., Åšwiderski, J., Szabolics, Å. ., Szawlowski, T., Szepesi, M., Suzuki, G., Tã¡l, T. T., Tala, B., Talbot, T., Talebzadeh, A. R., Taliercio, S., Cesare, Tamain, Tame, P., Tang, C., Tardocchi, W., Taroni, M., Taylor, L., Taylor, D., Tegnered, K. A., Telesca, D., Teplova, G., Terranova, N., David, Testa, Tholerus, D., Thomas, E., Thomas, J., Thomas, J. D., Thompson, P., Thompson, A., Thompson, C. A., Thorne, V. K., Thornton, L., Thrysã¸e, A., Tigwell, A. S., Tipton, P. A., Tiseanu, N., Tojo, I., Tokitani, H., Tolias, M., Tomeå¡, P., Tonner, M., Towndrow, P., Trimble, M., Tripsky, P., Tsalas, M., Tsavalas, M., Tskhakaya, Jun, Turner, D., Turner, I., Turnyanskiy, M. M., Tvalashvili, M., Tyrrell, G., Uccello, S. G. J., Abidin, Ul, Uljanovs, Z., Ulyatt, J., Urano, D., Uytdenhouwen, H., Vadgama, I., Valcarcel, A. P., Valentinuzzi, D., Valisa, M., Vallejos, Olivares, Valovic, P., Van De Mortel, Van, Eester, Van, Renterghem, Van, Rooij, Varje, G. J., Varoutis, J., Vartanian, S., Vasava, S., Vasilopoulou, K., Vega, T., Verdoolaege, J., Verhoeven, G., Verona, R., Verona, Rinati, Veshchev, G., Vianello, E., Vicente, N., Viezzer, J., Villari, E., Villone, S., Vincenzi, F., Pietro, Vinyar, Viola, I., Vitins, B., Vizvary, A., Vlad, Z., Voitsekhovitch, M., Vondrã¡äek, I., Vora, P., Vu, N., Pires De Sa, Wakeling, W. W., Waldon, B., Walkden, C. W. F., Walker, N., Walker, M., Walsh, R., Wang, M., Wang, E., Warder, N., Warren, S., Waterhouse, R. J., Watkins, J., Watts, N. W., Wauters, C., Weckmann, T., Weiland, A., Weisen, J., Weiszflog, H., Wellstood, M., West, C., Wheatley, A. T., Whetham, M. R., Whitehead, S., Whitehead, A. M., Widdowson, B. D., Wiesen, A. M., Wilkinson, S., Williams, J., Wilson, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wischmeier, J., Withenshaw, M., Withycombe, G., Witts, A., Wood, D. M., Wood, D., Woodley, R., Wray, C., Wright, S., Wright, J., J. C., Wu, Wukitch, J., Wynn, S., Xu, A., Yadikin, T., Yanling, D., Yao, W., Yavorskij, L., Yoo, V., Young, M. G., Young, C., Young, D., Young, I. D., Zacks, R., Zagorski, J., Zaitsev, R., Zanino, F. S., Zarins, R., Zastrow, A., Zerbini, K. D., Zhang, M., Zhou, W., Zilli, Y., Zoita, E., Zoletnik, V., Zychor, S., I, JET Contributors, Salewski, M, Nocente, M, Jacobsen, A, Binda, F, Cazzaniga, C, Ericsson, G, Eriksson, J, Gorini, G, Hellesen, C, Hjalmarsson, A, Kiptily, V, Koskela, T, Korsholm, S, Kurki Suonio, T, Leipold, F, Madsen, J, Moseev, D, Nielsen, S, Rasmussen, J, Schneider, M, Sharapov, S, Stejner, M, and Tardocchi, M
- Subjects
Nuclear and High Energy Physics ,gamma-ray spectrometry ,Neutron emission ,Fluids & Plasmas ,Astrophysics::High Energy Astrophysical Phenomena ,Nuclear Theory ,01 natural sciences ,7. Clean energy ,Atomic ,010305 fluids & plasmas ,Ion ,Nuclear physics ,Particle and Plasma Physics ,Physics::Plasma Physics ,0103 physical sciences ,fast ion ,γ-ray spectrometry ,Neutron ,Nuclear ,Emission spectrum ,fast ions ,010306 general physics ,Nuclear Experiment ,tokamak ,Nuclear and High Energy Physic ,Physics ,Jet (fluid) ,Neutron stimulated emission computed tomography ,Gamma ray ,Molecular ,neutron emission spectrometry ,velocity-space tomography ,Condensed Matter Physics ,Physics::Accelerator Physics ,Atomic physics ,Ion cyclotron resonance - Abstract
© 2017 Technical University of Denmark. We demonstrate the measurement of a 2D MeV-range ion velocity distribution function by velocity-space tomography at JET. Deuterium ions were accelerated into the MeV-range by third harmonic ion cyclotron resonance heating. We made measurements with three neutron emission spectrometers and a high-resolution γ-ray spectrometer detecting the γ-rays released in two reactions. The tomographic inversion based on these five spectra is in excellent agreement with numerical simulations with the ASCOT-RFOF and the SPOT-RFOF codes. The length of the measured fast-ion tail corroborates the prediction that very few particles are accelerated above 2 MeV due to the weak wave-particle interaction at higher energies.
- Published
- 2017
10. A Comparison between Torasemide and Furosemide Effects after Application Upon One Kidney or after I.V. Injection in the Rat
- Author
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Genard, J., Penninckx, R., Capel, B., Lenoir, R., Kramp, R., Andreucci, V. E., editor, and Dal Canton, Antonio, editor
- Published
- 1987
- Full Text
- View/download PDF
11. Effects of Torasemide’s Metabolites on Water and Electrolyte Excretion in the Rat
- Author
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Genard, J., Penninckx, R., Capel, B., Lenoir, R., Kramp, R., Andreucci, V. E., editor, and Dal Canton, Antonio, editor
- Published
- 1987
- Full Text
- View/download PDF
12. Sexually Dimorphic Vascular Development in the XY Mouse Gonad
- Author
-
Brennan, J. R. and Capel, B.
- Subjects
Developmental biology -- Research ,Gonads -- Physiological aspects ,Dimorphism (Animals) -- Research ,Cell research -- Analysis ,Biological sciences - Abstract
In mammals, a gonad primordium forms in XX and XY embryos that is bipotential and develops into either a testis or an ovary, depending on the expression of Sry. Sry induces morphogenetic changes in the gonad that result in typical testis structure, including an increase in size, the organization of testis cords, and the establishment of a male-specific vasculature. Between 11.5 and 12.5 dpc, Sry induces vascular and smooth muscle cell migration from the mesonephros into the XY gonad. The active recruitment of endothelial cells from the adjacent mesonephros and the appearance of a large, characteristic vessel specifically in the XY gonad indicate that there is an early bifurcation in vascular development between XX and XY gonads. This occurs as the developing testis is undergoing rapid organization, suggesting that construction of a specific vasculature plays an important role in the early patterning and function of the organ. We have examined the vascular architecture of XY vs XX gonads during this time frame to understand how vascular migration and XY patterning affect the development of the testis. Staining with markers for specific subsets of the vasculature, such as lymphatic vessels or arteries/veins has provided additional information suggesting that the XY gonad employs alternate mechanisms of vascular development. Preliminary results indicate that signaling molecules in the Ephrin, Notch, PDGF, and FGF pathways are important for proper vessel patterning in the XY gonad. It is important for organs to develop specialized vascular systems which are linked to organ function, although little is known about the acquisition of these specialized traits or the role of the vasculature in the morphogenesis and patterning of organs. The gonad provides us with a unique model system to address these questions because of the bipotential origin of the testis and ovary and their subsequent divergence in vascular development following Sry expression.
- Published
- 2001
13. The Role of FGF9 and Proliferation in Sex Determination
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Schmahl, J. P., Colvin, J., Ornitz, D., and Capel, B.
- Subjects
Developmental biology -- Research ,Sex determination, Genetic -- Research ,Testis -- Growth ,Cell research -- Analysis ,Biological sciences - Abstract
The initiation of testis development in mammals depends on the presence or absence of the Y chromosome-linked gene, Sry. Much is known about the early morphological changes that are initiated downstream of Sry, yet the molecular targets of Sry and other molecular signals that direct early testis formation are largely unknown. Recently, fgf9 knockout mice were found to undergo male to female sex reversal: despite the presence of a Y chromosome, fgf9-/- XY mice form abnormal testes or ovaries. We have investigated the role fgf9 in male sex determination. Fgf9-/- gonads show a proliferation decrease in SFl-positive cells near the coelomic epithelium. This population gives rise to male-specific cell types such as Sertoli and Leydig cells. Later in gonad formation, fgf9-/- XY gonads continue to proliferate at a lower rate and have few or no Sertoli and Leydig cells, suggesting that sex reversal in fgf9-/- XY gonads may be caused by a reduction in the number of male-specific cell types that direct testis development. In cultured gonads, FGF9 induces proliferation of many cell types. FGF9 also induces other male-specific events in culture, such as an increase in laminin deposition, the migration of vascular cells, and the formation of a male vascular pattern. However, FGF9 does not induce Sertoli differentiation, indicating that although FGF9 is part of the pathway for male sex determination, it is not the only piece.
- Published
- 2001
14. Cell Proliferation Is Necessary for the Induction of the Testis Pathway in the XY Gonad
- Author
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Schmahl, J P and Capel, B
- Subjects
Gonads -- Physiological aspects ,Cell division -- Physiological aspects ,Testis -- Physiological aspects ,Sex determination, Genetic -- Analysis ,Biological sciences - Abstract
Sry is the only gene on the Y chromosome that is required to induce testis formation in mammals. We have shown that Sry induces cell proliferation in the coelomic epithelium of the XY gonad, in a population that includes Sertoli cells. This cell proliferation leads to an early size increase of the testis over the ovary. Proliferation also appears to be necessary for the induction of the testis pathway. Inhibition of proliferation in culture or in vivo blocks testis cord formation and the expression of male specific genes, while inducing the expression of female specific genes. This apparent sex reversal of the XY gonad can be induced only during a 3-4 hour window in vivo, corresponding to a stage just before the peak of Sry expression and the appearance of male specific proliferation. Inhibition of proliferation before or after this critical stage leads to smaller testes, but not sex reversal. We are investigating several candidates for the factor(s) that induce proliferation downstream of Sry, identified by their expression in the XY coelomic epithelium and by the occurrence of sex reversal in knockout mice. An increase in cell proliferation in the male gonad has been noted in many organisms, such as chickens, turtles and alligators, that are not known to posses Sry, suggesting that cell proliferation may be a conserved mechanism for sex determination in vertebrates.
- Published
- 2000
15. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal
- Author
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Syed, H. A., Magwene, P. M., Capel, B., Munger, S. C., Aylor, D. L., and Threadgill, D. W.
- Abstract
Despite the identification of some key genes that regulate sex determination, most cases of disorders of sexual development remain unexplained. Evidence suggests that the sexual fate decision in the developing gonad depends on a complex network of interacting factors that converge on a critical threshold. To elucidate the transcriptional network underlying sex determination, we took the first expression quantitative trait loci (eQTL) approach in a developing organ. We identified reproducible differences in the transcriptome of the embryonic day 11.5 (E11.5) XY gonad between C57BL/6J (B6) and 129S1/SvImJ (129S1), indicating that the reported sensitivity of B6 to sex reversal is consistent with a higher expression of a female-like transcriptome in B6. Gene expression is highly variable in F2 XY gonads from B6 and 129S1 intercrosses, yet strong correlations emerged. We estimated the F2 coexpression network and predicted roles for genes of unknown function based on their connectivity and position within the network. A genetic analysis of the F2 population detected autosomal regions that control the expression of many sex-related genes, including Sry (sex-determining region of the Y chromosome) and Sox9 (Sry-box containing gene 9), the key regulators of male sex determination. Our results reveal the complex transcription architecture underlying sex determination, and provide a mechanism by which individuals may be sensitized for sex reversal.
- Published
- 2009
- Full Text
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16. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage
- Author
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Bradley Shaffer, H. (H), Minx, P. (Patrick), Warren, D.E. (Daniel E.), Shedlock, A.M. (Andrew M.), Thomson, R.C. (Robert C.), Valenzuela, N. (Nicole), Abramyan, J. (John), Amemiya, C.T. (Chris T.), Badenhorst, D. (Daleen), Biggar, K.K. (Kyle K.), Borchert, G.M. (Glen M.), Botka, C.W. (Christopher W.), Bowden, R.M. (Rachel M.), Braun, E.L. (Edward L.), Bronikowski, A.M. (Anne M.), Bruneau, B.G. (Benoit G.), Buck, L.T. (Leslie T.), Capel, B. (Blanche), Castoe, T.A. (Todd A.), Czerwinski, M. (Mike), Delehaunty, K.D. (Kim D.), Edwards, S.V. (Scott V.), Fronick, C.C. (Catrina C.), Fujita, M.K. (Matthew K.), Fulton, L. (Lucinda), Graves, T.A. (Tina A.), Green, R.E. (Richard E.), Haerty, W. (Wilfried), Hariharan, R. (Ramkumar), Hernandez, O. (Omar), Hillier, L.W. (LaDeana W.), Holloway, A.K. (Alisha K.), Janes, D. (Daniel), Janzen, F.J. (Fredric J.), Kandoth, C. (Cyriac), Kong, L. (Lesheng), de Koning, A.P.J. (A.P. Jason), Li, Y. (Yang), Literman, R. (Robert), McGaugh, S.E. (Suzanne E.), Mork, L. (Lindsey), O'Laughlin, M. (Michelle), Paitz, R.T. (Ryan T.), Pollock, D.D. (David D.), Ponting, C.P. (Chris P.), Radhakrishnan, S. (Srihari), Raney, B.J. (Brian J.), Richman, J.M. (Joy M.), St John, J. (John), Schwartz, T. (Tonia), Sethuraman, A. (Arun), Spinks, P.Q. (Phillip Q.), Storey, K. (Kenneth B.), Thane, N. (Nay), Vinar, T. (Tomas), Zimmerman, L.M. (Laura M.), Warren, W.C. (Wesley C.), Mardis, E.R. (Elaine R.), Wilson, R.K. (Richard K.), Bradley Shaffer, H. (H), Minx, P. (Patrick), Warren, D.E. (Daniel E.), Shedlock, A.M. (Andrew M.), Thomson, R.C. (Robert C.), Valenzuela, N. (Nicole), Abramyan, J. (John), Amemiya, C.T. (Chris T.), Badenhorst, D. (Daleen), Biggar, K.K. (Kyle K.), Borchert, G.M. (Glen M.), Botka, C.W. (Christopher W.), Bowden, R.M. (Rachel M.), Braun, E.L. (Edward L.), Bronikowski, A.M. (Anne M.), Bruneau, B.G. (Benoit G.), Buck, L.T. (Leslie T.), Capel, B. (Blanche), Castoe, T.A. (Todd A.), Czerwinski, M. (Mike), Delehaunty, K.D. (Kim D.), Edwards, S.V. (Scott V.), Fronick, C.C. (Catrina C.), Fujita, M.K. (Matthew K.), Fulton, L. (Lucinda), Graves, T.A. (Tina A.), Green, R.E. (Richard E.), Haerty, W. (Wilfried), Hariharan, R. (Ramkumar), Hernandez, O. (Omar), Hillier, L.W. (LaDeana W.), Holloway, A.K. (Alisha K.), Janes, D. (Daniel), Janzen, F.J. (Fredric J.), Kandoth, C. (Cyriac), Kong, L. (Lesheng), de Koning, A.P.J. (A.P. Jason), Li, Y. (Yang), Literman, R. (Robert), McGaugh, S.E. (Suzanne E.), Mork, L. (Lindsey), O'Laughlin, M. (Michelle), Paitz, R.T. (Ryan T.), Pollock, D.D. (David D.), Ponting, C.P. (Chris P.), Radhakrishnan, S. (Srihari), Raney, B.J. (Brian J.), Richman, J.M. (Joy M.), St John, J. (John), Schwartz, T. (Tonia), Sethuraman, A. (Arun), Spinks, P.Q. (Phillip Q.), Storey, K. (Kenneth B.), Thane, N. (Nay), Vinar, T. (Tomas), Zimmerman, L.M. (Laura M.), Warren, W.C. (Wesley C.), Mardis, E.R. (Elaine R.), and Wilson, R.K. (Richard K.)
- Abstract
Background: We describe the genome of the western painted turtle, Chrysemys picta bellii, one of the most widespread, abundant, and well-studied turtles. We place the genome into a comparative evolutionary context, and focus on genomic features associated with tooth loss, immune function, longevity, sex differentiation and determination, and the species' physiological capacities to withstand extreme anoxia and tissue freezing.Results: Our phylogenetic analyses confirm that turtles are the sister group to living archosaurs, and demonstrate an extraordinarily slow rate of sequence evolution in the painted turtle. The ability of the painted turtle to withstand complete anoxia and partial freezing appears to be associated with common vertebrate gene networks, and we identify candidate genes for future functional analyses. Tooth loss shares a common pattern of pseudogenization and degradation of tooth-specific genes with birds, although the rate of accumulation of mutations is much slower in the painted turtle. Genes associated with sex differentiation generally reflect phylogeny rather than convergence in sex determination functionality. Among gene families that demonstrate exceptional expansions or show signatures of strong natural selection, immune function and musculoskeletal patterning genes are consistently over-represented.Conclusions: Our comparative genomic analyses indicate that common vertebrate regulatory networks, some of which have analogs in human diseases, are often involved in the western painted turtle's extraordinary physiological capacities. As these regulatory pathways are analyzed at the functional level, the painted turtle may offer important insights into the management of a number of human health disorders.
- Published
- 2013
- Full Text
- View/download PDF
17. SESSION 65: THE OVARIAN FOLLICLE CAPITEL
- Author
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Capel, B., primary, Mork, L., additional, Maatouk, D. M., additional, McMahon, J. A., additional, McMahon, A. P., additional, Zhang, P., additional, and Telfer, E. E., additional
- Published
- 2012
- Full Text
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18. Preparing Recombinant Gonad Organ Cultures
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Capel, B., primary and Batchvarov, J., additional
- Published
- 2008
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19. Peritubular Myoid Cells Are Not the Migrating Population Required for Testis Cord Formation in the XY Gonad
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Cool, J., primary, Carmona, F.D., additional, Szucsik, J.C., additional, and Capel, B., additional
- Published
- 2008
- Full Text
- View/download PDF
20. Bmp7 Regulates Germ Cell Proliferation in Mouse Fetal Gonads
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Ross, A., primary, Munger, S., additional, and Capel, B., additional
- Published
- 2007
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- View/download PDF
21. Signaling at the crossroads of gonad development
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ROSS, A, primary and CAPEL, B, additional
- Published
- 2005
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22. Sry induces cell proliferation in the mouse gonad
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Schmahl, J., primary, Eicher, E.M., additional, Washburn, L.L., additional, and Capel, B., additional
- Published
- 2000
- Full Text
- View/download PDF
23. Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad
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Tilmann, C., primary and Capel, B., additional
- Published
- 1999
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24. Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge
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Capel, B., primary, Hawkins, J.R., additional, Hirst, E., additional, Kioussis, D., additional, and Lovell-Badge, R., additional
- Published
- 1996
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25. Expression of Sry, the mouse sex determining gene
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Hacker, A., primary, Capel, B., additional, Goodfellow, P., additional, and Lovell-Badge, R., additional
- Published
- 1995
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26. Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers
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Capel, B, primary, Hawley, RG, additional, and Mintz, B, additional
- Published
- 1990
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27. RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver.
- Author
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Zaphiropoulos, Peter G., Lewin, B., Sharp, P., Lang, K.M., Berget, S.M., Sterner, D.A., Gallego, M.E., Chabot, B., Chandler, S.H., Cogan, J.D., Hertel, K.J., Stark, J.M., Tacke, R., Graveley, B.R., Blencowe, B.J., Liu, H.-X., Nigro, J.M., Cocquerelle, C., Capel, B., and Bailleul, B.
- Published
- 1999
- Full Text
- View/download PDF
28. The battle of the sexes
- Author
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Capel, B.
- Published
- 2000
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29. Migration of mesonephric cells into the mammalian gonad depends on Sry
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Capel, B., Albrecht, K. H., Washburn, L. L., and Eicher, E. M.
- Published
- 1999
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- View/download PDF
30. Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice.
- Author
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Capel, B, Hawley, R, Covarrubias, L, Hawley, T, and Mintz, B
- Abstract
Mice were repopulated with small numbers of retrovirally marked hematopoietic cells operationally definable as totipotent hematopoietic stem cells, without engraftment of cells at later stages of hematopoiesis, in order to facilitate analysis of stem cell clonal histories. This result depended upon the use of unirradiated W/Wv newborn recipients. Before transplantation, viral integration markers were introduced during cocultivation of fetal liver or bone marrow cells with helper cell lines exporting defective recombinant murine retroviruses of the HHAM series. Omission of selection in culture [although the vector contained the bacterial neomycin-resistance (neo) gene] also limited the proportion of stem cells that were virally labeled. Under these conditions, engraftment was restricted to a small population of marked and unmarked normal donor stem cells, due to their competitive advantage over the corresponding defective cells of the mutant hosts. A relatively simple and coherent pattern emerged, of one or a few virally marked clones, in contrast to previous studies. In order to establish the totipotent hematopoietic stem cell identity of the engrafted cells, tissues were sampled for viral and inbred-strain markers for periods close to one year after transplantation. The virally labeled clones were characterized as stem cell clones by their extensive self-renewal and by formation of the wide range of myeloid and lymphoid lineages tested. Results clearly documented concurrent contributions of cohorts of stem cells to hematopoiesis. A given stem cell can increase or decrease its proliferative activity, become completely inactive or lost, or become active after a long latent period. The contribution of a single clone present in a particular lineage was usually between 5% and 20%.
- Published
- 1989
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31. Identification of a novel enterotoxigenic activity associated with Bacillus cereus.
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Melling, J, Capel, B J, Turnbull, P C, and Gilbert, R J
- Abstract
A strain of Bacillus cereus isolated from a food poisoning outbreak characterized by vomiting has been shown to be capable of causing vomiting when cultures grown on rice, but not other media, were fed to Rhesus monkeys. In contrast, a strain isolated from a diarrhoeal outbreak produced diarrhoea, but not vomiting, when grown on various media in similar feeding trials. Furthermore, culture filtrates from the diarrhoeal strain caused fluid accumulation in ligated rabbit ileal loops whereas those from the vomiting strain did not. It is proposed that at least two enterotoxins are involved, one responsible for the vomiting and one for the diarrhoeal symptoms. [ABSTRACT FROM PUBLISHER]
- Published
- 1976
32. Oestrogen shuts the door on SOX9
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Mork Lindsey and Capel Blanche
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Abstract Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by preventing nuclear localization of SOX9, a master regulator of the testis differentiation pathway. See research article http://www.biomedcentral.com/1741-7007/8/113
- Published
- 2010
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33. Circular transcripts of the testis-determining gene Sry in adult mouse testis
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Capel, B
- Published
- 1993
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34. OoCount: A Machine-Learning Based Approach to Mouse Ovarian Follicle Counting and Classification.
- Author
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Folts L, Martinez AS, Bunce C, Capel B, and McKey J
- Abstract
The number and distribution of ovarian follicles in each growth stage provides a reliable readout of ovarian health and function. Leveraging techniques for three-dimensional (3D) imaging of ovaries in toto has the potential to uncover total, accurate ovarian follicle counts. However, because of the size and holistic nature of these images, counting oocytes is time consuming and difficult. The advent of deep-learning algorithms has allowed for the rapid development of ultra-fast, automated methods to analyze microscopy images. In recent years, these pipelines have become more user-friendly and accessible to non-specialists. We used these tools to create OoCount, a high-throughput, open-source method for automatic oocyte segmentation and classification from fluorescent 3D microscopy images of whole mouse ovaries using a deep-learning convolutional neural network (CNN) based approach. We developed a fast tissue-clearing and spinning disk confocal-based imaging protocol to obtain 3D images of whole mount perinatal and adult mouse ovaries. Fluorescently labeled oocytes from 3D images of ovaries were manually annotated in Napari to develop a machine learning training dataset. This dataset was used to retrain StarDist using a CNN within DL4MicEverywhere to automatically label all oocytes in the ovary. In a second phase, we utilize Accelerated Pixel and Object Classification, a Napari plugin, to classify labeled oocytes and sort them into growth stages. Here, we provide an end-to-end protocol for producing high-quality 3D images of the perinatal and adult mouse ovary, obtaining follicle counts and staging. We also demonstrate how to customize OoCount to fit images produced in any lab. Using OoCount, we can obtain accurate counts of oocytes in each growth stage in the perinatal and adult ovary, improving our ability to study ovarian function and fertility., Summary Sentence: This protocol introduces OoCount, a high-throughput, open-source method for automatic oocyte segmentation and classification from fluorescent 3D microscopy images of whole mouse ovaries using a machine learning-based approach.
- Published
- 2024
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- View/download PDF
35. Bulk and single-cell transcriptome datasets of the mouse fetal and adult rete ovarii and surrounding tissues.
- Author
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Anbarci DN, O'Rourke R, Xiang Y, Peters DT, Capel B, and McKey J
- Subjects
- Animals, Female, Mice, Fetus, Gene Expression Profiling, Ovary embryology, Ovary growth & development, Transcriptome
- Abstract
The rete ovarii (RO) is an epithelial structure that arises during development in close proximity to the ovary and persists throughout adulthood. However, the functional significance of the RO remains elusive, and it is absent from recent discussions of female reproductive anatomy. The RO comprises three regions: the intraovarian rete within the ovary, the extraovarian rete in the periovarian tissue, and the connecting rete linking the two. We hypothesize that the RO plays a pivotal role in ovarian homeostasis and responses to physiological changes. To begin to uncover the nature and function of RO cells, we conducted transcriptomic profiling of the RO. This study presents three datasets, and reports our analysis and quality control approaches for bulk, single-cell, and nucleus-level transcriptomics of the fetal and adult RO tissues using the Pax8-rtTA; Tre-H2B-GFP mouse line, where all RO regions express nuclear GFP. The integration and rigorous validation of these datasets will advance our understanding of the RO's roles in ovarian development, female maturation, and adult female fertility., (© 2024. The Author(s).)
- Published
- 2024
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- View/download PDF
36. Rediscovering the Rete Ovarii : a secreting auxiliary structure to the ovary.
- Author
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Anbarci DN, McKey J, Levic DS, Bagnat M, and Capel B
- Abstract
The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray's Anatomy, it disappeared from recent textbooks, and is often dismissed as a functionless vestige in the adult ovary. Using PAX8 immunostaining and confocal microscopy, we characterized the fetal development of the RO in the context of the ovary. The RO consists of three distinct regions that persist in adult life, the intraovarian rete (IOR), the extraovarian rete (EOR), and the connecting rete (CR). While the cells of the IOR appear to form solid cords within the ovary, the EOR rapidly develops into a convoluted tubular epithelium ending in a distal dilated tip. Cells of the EOR are ciliated and exhibit cellular trafficking capabilities. The CR, connecting the EOR to the IOR, gradually acquires tubular epithelial characteristics by birth. Using microinjections into the distal dilated tip of the EOR, we found that luminal contents flow towards the ovary. Mass spectrometry revealed that the EOR lumen contains secreted proteins potentially important for ovarian function. We show that the cells of the EOR are closely associated with vasculature and macrophages, and are contacted by neuronal projections, consistent with a role as a sensory appendage of the ovary. The direct proximity of the RO to the ovary and its integration with the extraovarian landscape suggest that it plays an important role in ovary development and homeostasis., Competing Interests: Competing interests The authors declare no competing or financial interests.
- Published
- 2024
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- View/download PDF
37. Transcriptome analysis of the mouse fetal and adult rete ovarii and surrounding tissues.
- Author
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Anbarci DN, O'Rourke R, Xiang Y, Peters DT, Capel B, and McKey J
- Abstract
The rete ovarii (RO) is an epithelial structure that arises during fetal development in close proximity to the ovary and persists throughout adulthood in mice. However, the functional significance of the RO remains elusive, and it has been absent from recent discussions of female reproductive anatomy. The RO comprises three distinct regions: the intraovarian rete (IOR) within the ovary, the extraovarian rete (EOR) in the periovarian tissue, and the connecting rete (CR) linking the EOR and IOR. We hypothesize that the RO plays a pivotal role in maintaining ovarian homeostasis and responding to physiological changes. To uncover the nature and function of RO cells, we conducted transcriptome analysis, encompassing bulk, single-cell, and nucleus-level sequencing of both fetal and adult RO tissues using the Pax8-rtTA; Tre-H2B-GFP mouse line, where all RO regions express nuclear GFP. This study presents three datasets, which highlight RO-specific gene expression signatures and reveal differences in gene expression across the three RO regions during development and in adulthood. The integration and rigorous validation of these datasets will advance our understanding of the RO's roles in ovarian development, female maturation, and adult female fertility., Competing Interests: Competing interests The authors declare no competing or financial interests.
- Published
- 2023
- Full Text
- View/download PDF
38. Oxygen availability influences the incidence of testicular teratoma in Dnd1Ter/+ mice.
- Author
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Bustamante-Marin XM and Capel B
- Abstract
Testicular teratomas and teratocarcinomas are the most common testicular germ cell tumors in early childhood and young men, and they are frequently found unilaterally in the left testis. In 129/SvJ mice carrying a heterozygous copy of the potent modifier of tumor incidence Ter , a point mutation in the dead-end homolog one gene ( Dnd1
Ter/+ ), ∼70% of the unilateral teratomas arise in the left testis. We previously showed that in mice, left/right differences in vascular architecture are associated with reduced hemoglobin saturation and increased levels of the hypoxia inducible factor-1 alpha (HIF-1α) in the left compared to the right testis. To test the hypothesis that systemic reduction of oxygen availability in Dnd1Ter/+ mice would lead to an increased incidence of bilateral tumors, we placed pregnant females from 129/SvJ Dnd1Ter/+ intercross matings in a hypobaric chamber for 12-h intervals. Our results show that in 129/SvJ Dnd1Ter/+ male gonads, the incidence of bilateral teratoma increased from 3.3% to 64% when fetuses were exposed to acute low oxygen conditions for 12-h between E13.8 and E14.3. The increase in tumor incidence correlated with the maintenance of high expression of pluripotency genes Oct4 , Sox2 and Nanog , elevated activity of the Nodal signaling pathway, and suppression of germ cell mitotic arrest. We propose that the combination of heterozygosity for the Ter mutation and hypoxia causes a delay in male germ cell differentiation that promotes teratoma initiation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Bustamante-Marin and Capel.)- Published
- 2023
- Full Text
- View/download PDF
39. Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse.
- Author
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Bunce C, Barske L, Zhang G, and Capel B
- Subjects
- Female, Mice, Male, Animals, Sertoli Cells metabolism, Cell Differentiation, Embryonic Development, SOX9 Transcription Factor metabolism, Testis metabolism, Sex-Determining Region Y Protein genetics, Sex-Determining Region Y Protein metabolism, Mammals metabolism, Sex Determination Processes, Gonads metabolism
- Abstract
During mammalian development, gonadal sex determination results from the commitment of bipotential supporting cells to Sertoli or granulosa cell fates. Typically, this decision is coordinated across the gonad to ensure commitment to a single organ fate. When unified commitment fails in an XY mouse, an ovotestis forms in which supporting cells in the center of the gonad typically develop as Sertoli cells, while supporting cells in the poles develop as granulosa cells. This central bias for Sertoli cell fate was thought to result from the initial expression of the drivers of Sertoli cell fate, SRY and/or SOX9, in the central domain, followed by paracrine expansion to the poles. However, we show here that the earliest cells expressing SRY and SOX9 are widely distributed across the gonad. In addition, Sertoli cell fate does not spread among supporting cells through paracrine relay. Instead, we uncover a center-biased pattern of supporting cell precursor ingression that occurs in both sexes and results in increased supporting cell density in the central domain. Our findings prompt a new model of gonad patterning in which a density-dependent organizing principle dominates Sertoli cell fate stabilization., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2023. Published by The Company of Biologists Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
40. The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.
- Author
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Ruthig VA, Hatkevich T, Hardy J, Friedersdorf MB, Mayère C, Nef S, Keene JD, and Capel B
- Subjects
- Animals, Female, Male, Mice, Pregnancy, Chromatin metabolism, Neoplasm Proteins genetics, RNA-Binding Proteins genetics, Spermatogonia metabolism, Zebrafish genetics, Zebrafish metabolism
- Abstract
DND1 is essential to maintain germ cell identity. Loss of Dnd1 function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in zebrafish. Using our knock-in mouse line in which a functional fusion protein between DND1 and GFP is expressed from the endogenous locus (Dnd1GFP), we distinguished two male germ cell (MGC) populations during late gestation cell cycle arrest (G0), consistent with recent reports of heterogeneity among MGCs. Most MGCs express lower levels of DND1-GFP (DND1-GFP-lo), but some MGCs express elevated levels of DND1-GFP (DND1-GFP-hi). A RNA-seq time course confirmed high Dnd1 transcript levels in DND1-GFP-hi cells along with 5-10-fold higher levels for multiple epigenetic regulators. Using antibodies against DND1-GFP for RNA immunoprecipitation (RIP)-sequencing, we identified multiple epigenetic and translational regulators that are binding targets of DND1 during G0 including DNA methyltransferases (Dnmts), histone deacetylases (Hdacs), Tudor domain proteins (Tdrds), actin dependent regulators (Smarcs), and a group of ribosomal and Golgi proteins. These data suggest that in DND1-GFP-hi cells, DND1 hosts coordinating mRNA regulons that consist of functionally related and localized groups of epigenetic enzymes and translational components., Competing Interests: The authors have no competing interests to disclose., (Copyright: © 2023 Ruthig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2023
- Full Text
- View/download PDF
41. Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii.
- Author
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McKey J, Anbarci DN, Bunce C, Ontiveros AE, Behringer RR, and Capel B
- Subjects
- Humans, Female, Mice, Animals, Fetus, Morphogenesis, Ligaments, Mammals, Ovary, Oviducts
- Abstract
Morphogenetic events during the development of the fetal ovary are crucial to the establishment of female fertility. However, the effects of structural rearrangements of the ovary and surrounding reproductive tissues on ovary morphogenesis remain largely uncharacterized. Using tissue clearing and lightsheet microscopy, we found that ovary folding correlated with regionalization into cortex and medulla. Relocation of the oviduct to the ventral aspect of the ovary led to ovary encapsulation, and mutual attachment of the ovary and oviduct to the cranial suspensory ligament likely triggered ovary folding. During this process, the rete ovarii (RO) elaborated into a convoluted tubular structure extending from the ovary into the ovarian capsule. Using genetic mouse models in which the oviduct and RO are perturbed, we found the oviduct is required for ovary encapsulation. This study reveals novel relationships among the ovary and surrounding tissues and paves the way for functional investigation of the relationship between architecture and differentiation of the mammalian ovary., Competing Interests: JM, DA, CB, AO, RB, BC No competing interests declared, (© 2022, McKey et al.)
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- 2022
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42. Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.
- Author
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Mayère C, Regard V, Perea-Gomez A, Bunce C, Neirijnck Y, Djari C, Bellido-Carreras N, Sararols P, Reeves R, Greenaway S, Simon M, Siggers P, Condrea D, Kühne F, Gantar I, Tang F, Stévant I, Batti L, Ghyselinck NB, Wilhelm D, Greenfield A, Capel B, Chaboissier MC, and Nef S
- Abstract
Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, specification, and subsequent sex-specific differentiation of a previously uncharacterized population of supporting-like cells (SLCs) in the developing mouse gonads. The SLC lineage is closely related to the coelomic epithelium and specified as early as E10.5, making it the first somatic lineage to be specified in the bipotential gonad. SLC progenitors are localized within the genital ridge at the interface with the mesonephros and initially coexpress Wnt4 and Sox9 . SLCs become sexually dimorphic around E12.5, progressively acquire a more Sertoli- or pregranulosa-like identity and contribute to the formation of the rete testis and rete ovarii. Last, we found that WNT4 is a crucial regulator of the SLC lineage and is required for normal development of the rete testis.
- Published
- 2022
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- View/download PDF
43. Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†.
- Author
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Li SY, Gu X, Heinrich A, Hurley EG, Capel B, and DeFalco T
- Subjects
- Animals, Embryo, Mammalian embryology, MafB Transcription Factor metabolism, Male, Mice, Proto-Oncogene Proteins c-maf metabolism, MafB Transcription Factor genetics, Myeloid Cells metabolism, Organogenesis genetics, Proto-Oncogene Proteins c-maf genetics, Testis embryology
- Abstract
Testis differentiation is initiated when Sry in pre-Sertoli cells directs the gonad toward a male-specific fate. Sertoli cells are essential for testis development, but cell types within the interstitial compartment, such as immune and endothelial cells, are also critical for organ formation. Our previous work implicated macrophages in fetal testis morphogenesis, but little is known about genes underlying immune cell development during organogenesis. Here, we examine the role of the immune-associated genes Mafb and Maf in mouse fetal gonad development, and we demonstrate that deletion of these genes leads to aberrant hematopoiesis manifested by supernumerary gonadal monocytes. Mafb; Maf double knockout embryos underwent initial gonadal sex determination normally, but exhibited testicular hypervascularization, testis cord formation defects, Leydig cell deficit, and a reduced number of germ cells. In general, Mafb and Maf alone were dispensable for gonad development; however, when both genes were deleted, we observed significant defects in testicular morphogenesis, indicating that Mafb and Maf work redundantly during testis differentiation. These results demonstrate previously unappreciated roles for Mafb and Maf in immune and vascular development and highlight the importance of interstitial cells in gonadal differentiation., (© The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2021
- Full Text
- View/download PDF
44. Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging.
- Author
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Bunce C, McKey J, and Capel B
- Subjects
- Animals, Embryo, Mammalian physiology, Female, Gestational Age, Kidney physiology, Male, Mesonephros physiology, Mice, Mice, Inbred C57BL, Sex Differentiation physiology, Gonads physiology, Morphogenesis physiology, Wolffian Ducts physiology
- Abstract
During development of the mouse urogenital complex, the gonads undergo changes in three-dimensional structure, body position and spatial relationship with the mesonephric ducts, kidneys and adrenals. The complexity of genital ridge development obscures potential connections between morphogenesis and gonadal sex determination. To characterize the morphogenic processes implicated in regulating gonad shape and fate, we used whole-embryo tissue clearing and light sheet microscopy to assemble a time course of gonad development in native form and context. Analysis revealed that gonad morphology is determined through anterior-to-posterior patterns as well as increased rates of growth, rotation and separation in the central domain that may contribute to regionalization of the gonad. We report a close alignment of gonad and mesonephric duct movements as well as delayed duct development in a gonad dysgenesis mutant, which together support a mechanical dependency linking gonad and mesonephric duct morphogenesis., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2021. Published by The Company of Biologists Ltd.)
- Published
- 2021
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45. A brief review of vertebrate sex evolution with a pledge for integrative research: towards ' sexomics '.
- Author
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Stöck M, Kratochvíl L, Kuhl H, Rovatsos M, Evans BJ, Suh A, Valenzuela N, Veyrunes F, Zhou Q, Gamble T, Capel B, Schartl M, and Guiguen Y
- Subjects
- Animals, Evolution, Molecular, Female, Male, Ovary growth & development, Testis growth & development, Biological Evolution, Genome Size, Sex Chromosomes genetics, Sex Determination Processes, Sex Differentiation genetics, Vertebrates genetics
- Abstract
Triggers and biological processes controlling male or female gonadal differentiation vary in vertebrates, with sex determination (SD) governed by environmental factors or simple to complex genetic mechanisms that evolved repeatedly and independently in various groups. Here, we review sex evolution across major clades of vertebrates with information on SD, sexual development and reproductive modes. We offer an up-to-date review of divergence times, species diversity, genomic resources, genome size, occurrence and nature of polyploids, SD systems, sex chromosomes, SD genes, dosage compensation and sex-biased gene expression. Advances in sequencing technologies now enable us to study the evolution of SD at broader evolutionary scales, and we now hope to pursue a sexomics integrative research initiative across vertebrates. The vertebrate sexome comprises interdisciplinary and integrated information on sexual differentiation, development and reproduction at all biological levels, from genomes, transcriptomes and proteomes, to the organs involved in sexual and sex-specific processes, including gonads, secondary sex organs and those with transcriptional sex-bias. The sexome also includes ontogenetic and behavioural aspects of sexual differentiation, including malfunction and impairment of SD, sexual differentiation and fertility. Starting from data generated by high-throughput approaches, we encourage others to contribute expertise to building understanding of the sexomes of many key vertebrate species. This article is part of the theme issue 'Challenging the paradigm in sex chromosome evolution: empirical and theoretical insights with a focus on vertebrates (Part I)'.
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- 2021
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46. Sex determination without sex chromosomes.
- Author
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Weber C and Capel B
- Subjects
- Animals, Epigenesis, Genetic, Evolution, Molecular, Sex Chromosomes, Sex Determination Processes, Vertebrates genetics
- Abstract
With or without sex chromosomes, sex determination is a synthesis of many molecular events that drives a community of cells towards a coordinated tissue fate. In this review, we will consider how a sex determination pathway can be engaged and stabilized without an inherited genetic determinant. In many reptilian species, no sex chromosomes have been identified, yet a conserved network of gene expression is initiated. Recent studies propose that epigenetic regulation mediates the effects of temperature on these genes through dynamic post-transcriptional, post-translational and metabolic pathways. It is likely that there is no singular regulator of sex determination, but rather an accumulation of molecular events that shift the scales towards one fate over another until a threshold is reached sufficient to maintain and stabilize one pathway and repress the alternative pathway. Investigations into the mechanism underlying sex determination without sex chromosomes should focus on cellular processes that are frequently activated by multiple stimuli or can synthesize multiple inputs and drive a coordinated response. This article is part of the theme issue 'Challenging the paradigm in sex chromosome evolution: empirical and theoretical insights with a focus on vertebrates (Part I)'.
- Published
- 2021
- Full Text
- View/download PDF
47. Differentiation of fetal sertoli cells in the adult testis.
- Author
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Yokonishi T and Capel B
- Subjects
- Animals, Female, Male, Mice, Pregnancy, Seminiferous Tubules cytology, Seminiferous Tubules physiology, Sexual Maturation, Testis physiology, Cell Differentiation, Fetus cytology, Sertoli Cells cytology, Sertoli Cells transplantation, Spermatogenesis, Testis cytology
- Abstract
Sertoli cells proliferate and construct seminiferous tubules during fetal life, then undergo differentiation and maturation in the prepubertal testes. In the adult testes, mature Sertoli cells maintain spermatogonia and support spermatogenesis during the entire lifetime. Although Sertoli-like cells have been derived from iPS cells, they tend to remain immature. To investigate whether Sertoli cells can spontaneously acquire the ability to support spermatogenesis when transferred into the adult testis, we transplanted mouse fetal testicular cells into a Sertoli-depleted adult testis. We found that donor E12.5, E14.5 and E16.5 Sertoli cells colonized adult seminiferous tubules and supported host spermatogenesis 2 months after transplantation, demonstrating that immature fetal Sertoli cells can undergo sufficient maturation in the adult testis to become functional. This technique will be useful to analyze the developmental process of Sertoli cell maturation and to investigate the potential of iPS-derived Sertoli cells to colonize, undergo maturation, and support spermatogenesis within the testis environment.
- Published
- 2021
- Full Text
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48. Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.
- Author
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Garrett A, Rakhilin N, Wang N, McKey J, Cofer G, Anderson RB, Capel B, Johnson GA, and Shen X
- Subjects
- Animals, Mice, Peripheral Nervous System, Pressure, Diffusion Tensor Imaging, White Matter
- Abstract
Objective. The peripheral nervous system (PNS) connects the central nervous system with the rest of the body to regulate many physiological functions and is therapeutically targeted to treat diseases such as epilepsy, depression, intestinal dysmotility, chronic pain, and more. However, we still lack understanding of PNS innervation in most organs because the large span, diffuse nature, and small terminal nerve bundle fibers have precluded whole-organism, high resolution mapping of the PNS. We sought to produce a comprehensive peripheral nerve atlas for use in future interrogation of neural circuitry and selection of targets for neuromodulation. Approach. We used diffusion tensor magnetic resonance imaging (DT-MRI) with high-speed compressed sensing to generate a tractogram of the whole mouse PNS. The tractography generated from the DT-MRI data is validated using lightsheet microscopy on optically cleared, antibody stained tissue. Main results. Herein we demonstrate the first comprehensive PNS tractography in a whole mouse. Using this technique, we scanned the whole mouse in 28 h and mapped PNS innervation and fiber network in multiple organs including heart, lung, liver, kidneys, stomach, intestines, and bladder at 70 µ m resolution. This whole-body PNS tractography map has provided unparalleled information; for example, it delineates the innervation along the gastrointestinal tract by multiple sacral levels and by the vagal nerves. The map enabled a quantitative tractogram that revealed relative innervation of the major organs by each vertebral foramen as well as the vagus nerve. Significance. This novel high-resolution nerve atlas provides a potential roadmap for future neuromodulation therapies and other investigations into the neural circuits which drive homeostasis and disease throughout the body., (© 2021 IOP Publishing Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
49. A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.
- Author
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Ruthig VA, Yokonishi T, Friedersdorf MB, Batchvarova S, Hardy J, Garness JA, Keene JD, and Capel B
- Subjects
- Alleles, Animals, Cell Differentiation genetics, Embryo, Mammalian, Female, Gene Expression Regulation, Developmental, Genes, Reporter, Germ Cells physiology, Green Fluorescent Proteins metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neoplasm Proteins metabolism, RNA-Binding Proteins genetics, RNA-Binding Proteins metabolism, Recombinant Fusion Proteins genetics, Germ Cells metabolism, Green Fluorescent Proteins genetics, Neoplasm Proteins genetics
- Abstract
In vertebrates, the RNA-binding protein (RBP) dead end 1 (DND1) is essential for primordial germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or mutation leads to severe PGC loss soon after specification or, in some species, germ cell transformation to somatic lineages. Our investigations into the role of DND1 in PGC specification and differentiation have been limited by the absence of an available antibody. To address this problem, we used CRISPR/Cas9 gene editing to establish a transgenic mouse line carrying a DND1GFP fusion allele. We present imaging analysis of DND1GFP expression showing that DND1GFP expression is heterogeneous among male germ cells (MGCs) and female germ cells (FGCs). DND1GFP was detected in MGCs throughout fetal life but lost from FGCs at meiotic entry. In postnatal and adult testes, DND1GFP expression correlated with classic markers for the premeiotic spermatogonial population. Utilizing the GFP tag for RNA immunoprecipitation (RIP) analysis in MGCs validated this transgenic as a tool for identifying in vivo transcript targets of DND1. The DND1GFP mouse line is a novel tool for isolation and analysis of embryonic and fetal germ cells, and the spermatogonial population of the postnatal and adult testis., (© The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2021
- Full Text
- View/download PDF
50. The Chromatin State during Gonadal Sex Determination.
- Author
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Dupont S and Capel B
- Subjects
- Animals, Female, Gene Expression Regulation, Developmental, Gonads metabolism, Male, Mice, Polycomb Repressive Complex 1 genetics, Polycomb Repressive Complex 1 metabolism, SOX9 Transcription Factor genetics, SOX9 Transcription Factor metabolism, Sex Differentiation genetics, Testis metabolism, Chromatin metabolism, Sex Determination Processes genetics
- Abstract
At embryonic day (E) 10.5, prior to gonadal sex determination, XX and XY gonads are bipotential and able to differentiate into either a testis or an ovary. At this point, they are transcriptionally and morphologically indistinguishable. Sex determination begins around E11.5 in the mouse when the supporting cell lineage commits to either Sertoli or granulosa cell fate. Testis-specific factors such as SRY and SOX9 drive differentiation of bipotential-supporting cells into the Sertoli cell pathway, whereas ovary-specific factors like WNT4 and FOXL2 guide differentiation into granulosa cells. It is known that these 2 pathways are mutually antagonistic, and repression of the alternative fate is critical for maintenance of the testis or ovary programs. While we understand much about the transcription factor networks guiding the process of sex determination, it is only more recently that we have begun to understand how this process is epigenetically controlled. Studies in the past decade have demonstrated the importance of the chromatin state for gene expression and cell fate commitment, with histone modifications and DNA accessibility having a direct role in gene regulation. It is now clear that the chromatin state during sex determination is dynamic and likely critical for the establishment and/or maintenance of the transcriptional programs. Prior to sex determination, supporting cells have similar chromatin structure and histone modification profiles, reflecting the bipotential nature of these cells. After differentiation to Sertoli or granulosa cells, the chromatin state acquires sex-specific profiles. The proteins that regulate the deposition of histone modifications or the opening of compact chromatin likely play an important role in Sertoli and granulosa cell fate commitment and gonad development. Here, we describe studies profiling the chromatin state during gonadal sex determination and one example in which depletion of Cbx2, a member of the Polycomb Repressive Complex 1 (PRC1), causes male-to-female sex reversal due to a failure to repress the ovarian pathway., (© 2021 S. Karger AG, Basel.)
- Published
- 2021
- Full Text
- View/download PDF
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