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During the summer season, deep convection over the central United States has a significant impact on the dynamics and composition of the upper troposphere and lower stratosphere (UTLS). These storms transport tropospheric air containing trace gases, ice particles, and aerosols into the UTLS, which can affect chemical and radiative processes over a large region. Because overshooting storms necessarily have strong updrafts, there is a marked correlation between overshooting and the occurrence of severe weather at the surface. Heat released by these storms also helps to drive the North American Monsoon Anticyclone (NAMA) in the UTLS, which partially confines air injected into the stratosphere by overshooting storms. In support of the Dynamics and Chemistry of the Summer Stratosphere (DCOTSS) project, this study is a climatological analysis of the environmental factors that affect the occurrence of deep and overshooting storms. Using hourly analyses of overshooting storms based on GridRad radar data and ERA5 reanalyzes, we focus on the roles of convective available potential energy (CAPE), convective inhibition (CIN), jet location, and other relevant dynamical and thermodynamic variables. The results show that northward intrusion of airmasses containing moist high CAPE air from the Gulf of Mexico into the central plains plays a major role in producing the conditions necessary for overshooting storms with other factors playing secondary roles. Plain Language Summary: Using observations of the atmosphere, this research shows that strong convective storms, which are most likely to produce heavy rain and severe weather, are regulated primarily by the amount of energy available to drive the storms and the energy needed to initiate convection. The strongest storms can also penetrate into the overlying stratosphere, which contains the Earth's protective ozone layer, carrying air from the lower atmosphere into the stratosphere. This is significant in part because climate models predict that the amount of energy available for convection will increase as the climate warms. As a result, the impact of strong convection on the atmosphere and on the stratosphere in particular may increase over coming decades. Key Points: Overshooting convective storms have a global impact on the composition, chemistry, and radiative balance of the overlying stratosphereDeep and overshooting storms are strongly correlated with convective available potential energy (CAPE) and convective inhibition (CIN)CAPE and CIN are predicted to increase as the climate warms, potentially increasing the impact of overshooting storms on the stratosphere [ABSTRACT FROM AUTHOR]

Severe convection, responsible for hazards such as tornadoes, flash floods, and hail, is usually preceded by abundant convective available potential energy (CAPE). In this work, we use a Lagrangian approach to study the buildup of anomalously large values of CAPE from 2012 to 2013 in various regions. Nearly all extreme values of CAPE arise from surface fluxes underneath a layer of convective inhibition (the CIN layer) over several diurnal cycles, but the origin of the CIN layer and the diurnal cycle of surface fluxes differ around the world. In some regions, such as North America and Europe, the air above the boundary layer must be much warmer than usual to form this CIN layer, whereas in other regions, especially the Middle East and central Africa, a CIN layer is common. Additionally, high CAPE occurrences that are over land (those in the Americas, Europe, Africa, and Southeast Asia) tend to lose their CIN layers before the time of maximum CAPE due to large diurnal cycles of sensible heating, whereas those that occur over coastal waters (in the Middle East, Northern Australia, South Asia, and the Mediterranean) usually retain substantial convective inhibition. Uniquely, CAPE in Southeast Australia often builds up due to cooling aloft rather than to boundary layer warming. These results show that one hoping to understand or predict CAPE patterns must understand a variety of mechanisms acting in different regions. Plain Language Summary: The energy available to power severe storms that cause events such as tornadoes and hailstorms is known as convective available potential energy (CAPE). Therefore, these events are usually preceded by the buildup of anomalously large amounts of CAPE. Here, we study the processes by which CAPE accumulates in various parts of the world. In nearly all regions, warming and moistening of near‐surface air provides this energy, demonstrating the importance of surface fluxes. However, other characteristics of CAPE accumulation differ around the world, meaning that one hoping to understand how large CAPE values arise must consider specific regions. This work is a step toward understanding where and how frequently severe convective events occur, and if these events will change in the future. Key Points: Worldwide, accumulation of CAPE is usually caused by surface enthalpy flux mostly through latent heatingBuildup of CAPE requires a layer of convective inhibition, which in some regions is rare and in others is commonThe CIN accompanying CAPE maxima over water often never decays due to a lack of daytime surface sensible heating [ABSTRACT FROM AUTHOR]

Knowledge of the chemical composition of propolis is crucial for understanding the characteristics of products of different origins, but also for quality control and regulatory purposes. To date, official monographs or official analyses that allow researchers to evaluate propolis in a proper way have not yet been released. This study focuses on the characterization of twenty-seven Italian propolis samples and the identification of chemical markers that define its geographical provenance. Total polyphenol (TP) and total flavonoid (TF) content, alongside the quantification of pinocembrin, chrysin, galangin, and caffeic acid phenethyl ester (CAPE), were identified as potential markers. Additionally, DPPH assays were conducted to evaluate the antiradical activity of propolis samples. Our findings demonstrated that TPs, TFs and pinocembrin differed in propolis of different origins, especially in samples from the islands. However, the quantification of the sum of chrysin and galangin and CAPE provided a clearer distinction of the geographical origin of the propolis samples. In contrast, the DPPH assay did not prove useful for this purpose, as most results were similar and, therefore, not significant. This study lays the groundwork for future research on propolis. These findings could contribute to the development of more refined methods for distinguishing propolis origins, enhancing the understanding, valuation and quality control of this natural product in various applications. [ABSTRACT FROM AUTHOR]

Wind gustiness is an effective approach for addressing mesoscale enhancement in estimating air-sea interface fluxes. In this study, an improved convective gustiness parameterization scheme based on convective available potential energy (CAPE) is formulated utilizing reanalysis data and wind observations from moored buoys. This new parameterization was examined by implementing it in the air-sea flux transfer scheme within the National Center for Atmospheric Research Community Earth System Model (NCAR CESM) version 2.1.3 and contrasting it with a previously proposed scheme based on convective precipitation rate. The results indicate a significant reduction in negative biases of surface winds and latent heat fluxes over the tropical Indian Ocean and western Pacific during summer with the implementation of either gustiness scheme, resulting in an average increase in latent heat flux of approximately 9 W·m− 2. Specifically, the CAPE-based scheme shows a more favorable impact in the Indo-Pacific Warm Pool region, whereas the precipitation-based scheme exhibits inferior performance in the western Pacific Intertropical Convergence Zone. Further analysis reveals that the inclusion of the gustiness scheme distinctly alters surface evaporation and latent heat flux, influencing vertical motion in the area with active convective activity and effectively improving precipitation simulations by up to 18%. Moreover, the CAPE-based scheme reduces the bias in summer precipitation simulations by approximately 5% more than the precipitation-based scheme. [ABSTRACT FROM AUTHOR]

Spinal cord ischemia has serious sequelae. The aim of this study is to investigate the effects of resveratrol and caffeic acid phenyl ester (CAPE), a propolis derivative, on spinal cord injury induced by ischemia-reperfusion (IR). In our research, 30 male Wistar albino rats, 200–250 gr, were used. Before the experiment, during a week of the process, the rats were fed with these two agents, and the experimental group rats were exposed to spinal cord IR injury. At the end of the experiment, spinal cord samples were taken from the sacrificed rats. Bax, p53, nNOS, and Beclin-1 immunoreactivity moreover TUNEL (+) cells were evaluated with immunohistochemically in the IR-induced damaged rats. It has been clearly determined that the TUNEL (+) apoptotic cell number and immunopositive cells of nNOS, Beclin-1, p53, Bax were raised in the IR group. However, these increments partially were restored in the resveratrol and CAPE-fed rats with IR-induced injury. In light of our data, resveratrol, and CAPE could be beneficial in spinal cord IR injury. Although both agents provide beneficial effects, it can be said that CAPE is partially more effective in spinal cord injury caused by IR. [ABSTRACT FROM AUTHOR]

Heavy metals are pollutants that are generated by different activities, one of which is the dumping of wastewater by industries into bodies of water, which represents a great threat to aquatic and terrestrial biota, as well as health. These contaminants are persistent, bioaccumulative and non-biodegradable, generating a negative effect on the food chain in the area of influence. Nickel is a heavy metal that is used in different types of industries such as battery production. This generates different harmful effects on the human body, such as the cardiovascular or digestive system when exposed in large quantities. The objective of the present study is to use Computer Aided Process Engineering (CAPE) to model an operational column on an industrial scale aimed at the adsorption of Nickel (II) in aqueous solution taking advantage of the biomass of Theobroma cacao L. Consequently, Aspen Adsorption software was used to carry out multiple simulations of an adsorption column using various industrial configurations, with the aim of performing a parametric sensitivity analysis. In the results obtained, it is evident that the Langmuir model - global linear resistance kinetic model (LDF) used to simulate the adsorption column in the elimination of Nickel (II) achieves efficiencies of up to 95.8%. The best conditions for the simulation in the adsorption column were an inlet flow rate of 300 m3/day, a bed height of 5 m and an initial concentration of 2000 mg/L. Furthermore, it was observed that increasing the inlet flow led to a decrease in the rupture and saturation time of the process, while increasing the bed height presented an increase in the rupture and saturation time. On the other hand, concentration did not significantly affect the efficiency of the process. [ABSTRACT FROM AUTHOR]

Climate change in India is causing devastating downpour events and shifts in spatial characterization, with apparent regional differences. The Northwest India (NWI), which is in the Aravalli rain shadow zone and was formerly drier, has attracted great attention in recent years due to its changing rainfall patterns. This study throws light on the astonishing behaviour of ISMR over NWI with the advent of intensified rainfall over the region in the recent time frame. The Pettitt test of change point (CP) detection is utilized in this analysis to measure the change in rainfall patterns over a period of 70 years, from 1950 to 2019. This analysis suggests significant variation in the CP's time frame for different months of ISMR. The earliest change was noticed in July, while the latest was for September for the mean as well as for the intense precipitation. Moreover, we found a maximum change in the precipitation during the peak monsoon month (i.e., July and August). The difference in the precipitation of different percentile values before and after CP indicates a decrease (increase) in low (high) intensity precipitation for all the months and seasons as a whole with varying magnitude. The highest reduction of low‐intensity precipitation is noticed for the months of July and August, while the highest increase of high‐intensity precipitation (>95th percentile) is noticed for June and September. The heavier precipitation contributes largely to the mean increase of precipitation, expecting to receive more mean and precipitation extremes in the future. Unlike the increasing precipitation trend, potential evapotranspiration (source of local moisture) shows a declining trend, revealing the negative association among them and the possibility of enhanced advection of remote moisture responsible for enhanced precipitation over NWI. The enhanced vertically integrated moisture transport of the Arabian Sea and Bay of Bengal and its strengthening relationship with precipitation further confirm the contribution of remote moisture to intensified precipitation over NWI, though the in‐depth dynamical cause remains unclear. The increased Convective Available Potential Energy for entire monsoon seasons as a whole and individual months facilitates a favourable condition for enhanced convective activity over the region, resulting in strengthening the precipitation. [ABSTRACT FROM AUTHOR]

The mammalian gastrointestinal tract hosts a significant microbial symbiont community, an intriguing feature of this complex organ system. This study aimed to investigate the anti-inflammatory, antioxidant, and protective effects of caffeic acid phenethyl ester (CAPE) against Enterococcus faecalis infection in the stomach at a dose of 106 CFU in Swiss mice. A total of 30 mice were randomly assigned to three groups of ten mice each. Group I was the negative control, Group II was infected orally with E. faecalis for 18 days, and Group III was infected with E. faecalis and treated with CAPE orally at a daily dose of 4 mg/kg for 18 days. We assessed the antioxidant activities of stomach homogenate and the immunohistochemical expressions of the transcription factor nuclear factor kappa B (NF-κB) and proliferating cell nuclear antigen (PCNA). Histopathological examination was performed on the stomachs of all mice. Group II had decreased levels of antioxidant activity and positive expressions of NF-κB and PCNA. Histological observations revealed an increase in mucosal and glandular thickness compared with Group I. Group III, treated with CAPE, showed a significant increase in antioxidant activities and a significant decrease in NF-κB and PCNA immunoreactivities compared with Group II. In addition, Group III showed restoration of the normal thickness of the non-glandular and glandular parts of the stomach. Our results revealed that E. faecalis infection has damaging effects on the stomach and proved that CAPE has promising protective, anti-inflammatory, and antioxidant effects against E. faecalis. Further studies may investigate the potential therapeutic effects of CAPE against E. faecalis infection. [ABSTRACT FROM AUTHOR]

Abstract Background The treatment of spinal cord injury (SCI) has always been a significant research focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as well as oxidative stress key to successful SCI patient treatment. Caffeic acid phenethyl ester (CAPE), a compound extracted from propolis, has both anti-inflammatory and anti-oxidative effects, but its SCI therapeutic effects have rarely been reported. Methods We constructed a mouse spinal cord contusion model and administered CAPE intraperitoneally for 7 consecutive days after injury, and methylprednisolone (MP) was used as a positive control. Hematoxylin–eosin, Nissl, and Luxol Fast Blue staining were used to assess the effect of CAPE on the structures of nervous tissue after SCI. Basso Mouse Scale scores and footprint analysis were used to explore the effect of CAPE on the recovery of motor function by SCI mice. Western blot analysis and immunofluorescence staining assessed levels of inflammatory mediators and oxidative stress-related proteins both in vivo and in vitro after CAPE treatment. Further, reactive oxygen species (ROS) within the cytoplasm were detected using an ROS kit. Changes in mitochondrial membrane potential after CAPE treatment were detected with 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide. Mechanistically, western blot analysis and immunofluorescence staining were used to examine the effect of CAPE on the SIRT1/PGC1α/DRP1 signaling pathway. Results CAPE-treated SCI mice showed less neuronal tissue loss, more neuronal survival, and reduced demyelination. Interestingly, SCI mice treated with CAPE showed better recovery of motor function. CAPE treatment reduced the expression of inflammatory and oxidative mediators, including iNOS, COX-2, TNF-α, IL-1β, 1L-6, NOX-2, and NOX-4, as well as the positive control MP both in vitro and in vivo. In addition, molecular docking experiments showed that CAPE had a high affinity for SIRT1, and that CAPE treatment significantly activated SIRT1 and PGC1α, with down-regulation of DRP1. Further, CAPE treatment significantly reduced the level of ROS in cellular cytoplasm and increased the mitochondrial membrane potential, which improved normal mitochondrial function. After administering the SIRT1 inhibitor nicotinamide, the effect of CAPE on neuro-inflammation and oxidative stress was reversed.On the contrary, SIRT1 agonist SRT2183 further enhanced the anti-inflammatory and antioxidant effects of CAPE, indicating that the anti-inflammatory and anti-oxidative stress effects of CAPE after SCI were dependent on SIRT1. Conclusion CAPE inhibits microglia-mediated neuro-inflammation and oxidative stress and supports mitochondrial function by regulating the SIRT1/PGC1α/DRP1 signaling pathway after SCI. These effects demonstrate that CAPE reduces nerve tissue damage. Therefore, CAPE is a potential drug for the treatment of SCI through production of anti-inflammatory and anti-oxidative stress effects. Graphical Abstract

Copyright of Celal Bayar Üniversitesi Saglik Bilimleri Enstitüsü Dergisi is the property of Celal Bayar University Health Sciences Institute Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells preferentially in the bone marrow. Currently, emerging chemotherapy drugs with improved biosafety profiles, such as immunomodulatory agents and protease inhibitors, have been used in clinics to treat MM in both initial therapy or maintenance therapy post autologous hematopoietic stem cell transplantation (ASCT). We previously discovered that caffeic acid phenethyl ester (CAPE), a water-insoluble natural compound, inhibited the growth of MM cells by inducing oxidative stress. As part of our continuous effort to pursue a less toxic yet more effective therapeutic approach for MM, the objective of this study is to investigate the potential of CAPE for in vivo applications by using magnetic resonance imaging (MRI)-capable superparamagnetic iron oxide nanoparticles (IONP) as carriers. Cyclo (ArgGly-Asp-D-Phe-Cys) (RGD) is conjugated to IONP (RGD-IONP/CAPE) to target the overexpressed αvβ3 integrin on MM cells for receptor-mediated internalization and intracellular delivery of CAPE. A stable loading of CAPE on IONP can be achieved with a loading efficiency of 48.7% ± 3.3% (wt%). The drugrelease studies indicate RGD-IONP/CAPE is stable at physiological (pH 7.4) and basic pH (pH 9.5) and subject to release of CAPE at acidic pH (pH 5.5) mimicking the tumor and lysosomal condition. RGD-IONP/CAPE causes cytotoxicity specific to human MM RPMI8226, U266, and NCI-H929 cells, but not to normal peripheral blood mononuclear cells (PBMCs), with IC50s of 7.97 ± 1.39, 16.75 ± 1.62, and 24.38 ± 1.71 μM after 72-h treatment, respectively. Apoptosis assays indicate RGD-IONP/CAPE induces apoptosis of RPMI8226 cells through a caspase-9 mediated intrinsic pathway, the same as applying CAPE alone. The apoptogenic effect of RGD-IONP/CAPE was also confirmed on the RPMI8226 cells co-cultured with human bone marrow stromal cells HS-5 in a Transwell model to mimic the MM microenvironment in the bone marrow. In conclusion, we demonstrate that water-insoluble CAPE can be loaded to RGD-IONP to greatly improve the biocompatibility and significantly inhibit the growth of MM cells in vitro through the induction of apoptosis. This study paves the way for investigating the MRI-trackable delivery of CAPE for MM treatment in animal models in the future. [ABSTRACT FROM AUTHOR]

Caffeic acid phenethyl ester (CAPE) is an important active component of propolis with many bioactivities. However, its efficiency and practical application are restricted due to its poor aqueous solubility and storage stability. In this study, a nanocarrier was fabricated to encapsulate CAPE using self-assembled rice peptides obtained by controllable enzymolysis. The physicochemical properties, encapsulation efficiency, and loading capacity of rice peptides nanoparticles (RPNs) were characterized. The storage stability, in vitro release, and interaction mechanisms between CAPE and RPNs were investigated. The results showed that RPNs, mainly assembled by disulfide bonds and hydrogen bonds, possessed an effective diameter of around 210 nm and a high encapsulation efficiency (77.77%) and loading capacity (3.89%). Importantly, the water solubility of CAPE was increased by 45 times after RPNs encapsulation. Moreover, RPNs encapsulation also significantly increased CAPE stability, about 1.4-fold higher than that of unencapsulated CAPE after 18-day storage. An in vitro release study demonstrated that RPNs could delay the release of CAPE, implying a better CAPE protection against extreme environments during digestion. Hydrogen bond and van der Waals force are the predominant interaction forces between RPNs and CAPE. Therefore, the newly developed nanoparticle is a potential delivery system that could effectively improve the aqueous solubility and stability of CAPE. [ABSTRACT FROM AUTHOR]

This study provides a comprehensive review and detailed analysis of existing works based on deep learning for 3D pose estimation, transforming 2D clothing items into a person’s image using artificial intelligence (AI) techniques to develop virtual fitting rooms. The current results are presented and discussed, and we summarize the advantages and disadvantages of these existing methods and provide an in-depth understanding of the field. Besides, we present the commonly used standard datasets upon which comprehensive study is conducted for comparison and analysis.

As the Internet of Things (IoT) continues to expand, the volume of data generated by IoT devices and the demand for IoT applications is increasing exponentially. These applications critically rely on real-time context reasoned from IoT data for effective decision-making and actuation, thereby making the accessibility of this context crucial. This study introduces a novel adaptive Context Monitoring Framework (CMF) for enhancing context caching efficiency in Context Management Platforms (CMPs) to better support the near real-time needs of IoT applications. Our proposed framework integrates two novel components: the Context Attributes Prioritisation Engine (CAPE), which prioritises and assigns weights to the context, and the Adaptive Context Management Engine (ACME), which dynamically adjusts thresholds for each context based on incoming query volumes and context cache performance. Combined, our hybrid approach ensures timely updates of context within the cache while also serving context in real-time (reducing any query response latency). Our approach is effective for dynamic changes in an IoT environment through the adaptive approach of continuously monitoring and updating the cached context. We implemented the proposed adaptive framework using a CMP namely the context-as-a-service (CoaaS) platform and evaluated it using real-world datasets obtained from a smart city application. A thorough experimental evaluation demonstrated a marked improvement in cache efficiency, achieving a 90% cache hit rate and reducing the cache expiry ratio to 5%.

In this study, the performance of thermodynamic indices and atmospheric stability parameters in thunderstorm prediction was analyzed for a five-year period between 2018 and 2022 using data from Samsun radiosonde station and aviation observations from Samsun Çarşamba Airport. The thermodynamic indices and atmospheric stability parameters used in the study are Showalter Index (SI), Lifted Index (LI), Severe Weather Threat Index (SWEAT), K-Index (KI), Totals Totals Index (TTI), Convective Available Potential Energy (CAPE), Convective Inhibition (CIN), and Bulk Richardson Number (BRN). Statistical performance tests such as Probability of Detection (POD), False Alarm Ratio (FAR), Miss Rate (MR), Critical Success Index (CIS), Hiedke Skill Score (HSS), and True Skill Score (TSS) were used to measure the success of the indices and parameters in predicting thunderstorm events. The analyses were performed using R and Excel. According to the results, the most successful index in thunderstorm prediction was SI, while the performance of CAPE and BRN parameters was the lowest. Based on all these analyses, it is observed that the majority of thunderstorms occur during the hottest months of the year and the hottest hours of the day. This indicates that most thunderstorms occur due to heating. In some events, the indices and parameters did not even reach the threshold value determined for thunderstorm formation. It is obvious that the prediction accuracy will be further improved if the thresholds of the indices and parameters are optimized for Samsun. Furthermore, evaluating multiple indices and parameters instead of relying on a single index or parameter for thunderstorm prediction will increase consistency and lead to more accurate results.

The temporal and spatial scale dependent relation of Convective Available Potential Energy (CAPE) and precipitation is investigated. Using the COSMO-REA6 data set, we ask which of the standard machine learning algorithms: perceptron, support vector machine, decision tree, random forest, k-nearest neighbor and a simple kept deep neural network algorithm can best relate these two variables. Then, we concentrate on decision trees and evaluate the relation of CAPE and precipitation across different scales. We investigate temporal resolutions of 1 hour to 24 hours and horizontal resolutions of 6 km up to 768 km. Regarding ten CAPE and two precipitation classes we find accuracy scores mostly of about 0.7 across all scales. Taking the Dynamic State Index (DSI) as additional predictor into account leads to an overall increase of the scores. We further introduce a theoretical relation of CAPE and precipitation based on the works of Hans Ertel (1933), which will be analyzed in future studies. Today it is natural to tackle complex atmospheric processes using machine learning methods. These data based methods are suggested as additional tool to complement the results gained by the governing equations of atmospheric motion.

Knowledge of the chemical composition of propolis is crucial for understanding the characteristics of products of different origins, but also for quality control and regulatory purposes. To date, official monographs or official analyses that allow researchers to evaluate propolis in a proper way have not yet been released. This study focuses on the characterization of twenty-seven Italian propolis samples and the identification of chemical markers that define its geographical provenance. Total polyphenol (TP) and total flavonoid (TF) content, alongside the quantification of pinocembrin, chrysin, galangin, and caffeic acid phenethyl ester (CAPE), were identified as potential markers. Additionally, DPPH assays were conducted to evaluate the antiradical activity of propolis samples. Our findings demonstrated that TPs, TFs and pinocembrin differed in propolis of different origins, especially in samples from the islands. However, the quantification of the sum of chrysin and galangin and CAPE provided a clearer distinction of the geographical origin of the propolis samples. In contrast, the DPPH assay did not prove useful for this purpose, as most results were similar and, therefore, not significant. This study lays the groundwork for future research on propolis. These findings could contribute to the development of more refined methods for distinguishing propolis origins, enhancing the understanding, valuation and quality control of this natural product in various applications.

Lightning is one of the natural disasters that cause significant financial losses and even fatalities. Therefore, it is necessary to understand the characteristics of lightning and related factors take appropriate preventive and mitigation measures. This work investigated the influence of aerosols and atmospheric thermodynamic factors on lightning in Java Island using 16 years of data (1998 - 2013) from the Tropical Rainfall Measuring Mission (TRMM) satellite. Aerosol data were obtained from the Modern Era Retrospective Analysis for Research and Applications version 2 (MERRA-2). Furthermore, convective available potential energy (CAPE) and potential temperature data were taken from the fifth-generation ECMWF atmospheric reanalysis (ERA-5) data. The intensity of lightning strikes in the western part of Java, such as Jakarta and Banten, is higher than in the eastern part, corresponding to the distribution pattern of aerosols, especially sulfate aerosols, sea salt aerosols, and black carbon aerosols. Sea salt aerosols have an inverse relationship with lightning, as these coarse-sized aerosols tend to inhibit convection. An increase in CAPE and potential temperature generally leads to higher lightning intensity. However, in cases where CAPE values are extremely high, such as in Jakarta, the intensity of lightning decreases. A similar pattern can be observed with potential temperature. An inverse relationship between lightning and potential temperature is observed in regions at higher elevations. The peak time for CAPE and potential temperature coincide with the peak intensity of lightning, which typically occurs during the rainy season, while the peak of AOD occurs earlier, during the pre-monsoon (September-October-November). The highest values of sea salt AOD are observed during the dry season (June-July-August) when lightning is minimal. These variations in peak times are particularly evident in the western regions of Java, where AOD values are high. The findings of this study can aid in lightning disaster mitigation efforts on Java Island. [ABSTRACT FROM AUTHOR]

Convective available potential energy (CAPE) is an important index for storm forecasting. Recent versions (v15.2 and v16) of the Global Forecast System (GFS) predict lower values of CAPE during summertime in the continental United States than analysis and observation. We conducted an evaluation of the GFS in simulating summertime CAPE using an example from the Unified Forecast System Case Study collection to investigate the factors that lead to the low CAPE bias in GFS. Specifically, we investigated the surface energy budget, soil properties, and near-surface and upper-level meteorological fields. Results show that the GFS simulates smaller surface latent heat flux and larger surface sensible heat flux than the observations. This can be attributed to the slightly drier-than-observed soil moisture in the GFS that comes from an offline global land data assimilation system. The lower simulated CAPE in GFS v16 is related to the early drop of surface net radiation with excessive boundary layer cloud after midday when compared with GFS v15.2. A moisture-budget analysis indicates that errors in the large-scale advection of water vapor does not contribute to the dry bias in the GFS at low levels. Common Community Physics Package single-column model (SCM) experiments suggest that with realistic initial vertical profiles, SCM simulations generate a larger CAPE than runs with GFS IC. SCM runs with an active LSM tend to produce smaller CAPE than that with prescribed surface fluxes. Note that the findings are only applicable to this case study. Including more warm-season cases would enhance the generalizability of our findings. Significance Statement: Convective available potential energy (CAPE) is one of the key parameters for severe weather analysis. The low bias of CAPE is identified by forecasters as one of the key issues for the NOAA operational global numerical weather prediction model, Global Forecast System (GFS). Our case study shows that the lower CAPE in GFS is related to the drier atmosphere than observed within the lowest 1 km. Further investigations suggest that it is related to the drier atmosphere that already exists in the initial conditions, which are produced by the Global Data Assimilation System, in which an earlier 6-h GFS forecast is combined with current observations. It is also attributed to the slightly lower simulated soil moisture than observed. The lower CAPE in GFS v16 when compared with GFS v15.2 in the case analyzed here is related to excessive boundary layer cloud formation beginning at midday that leads to a drop of net radiation reaching the surface and thus less latent heat feeding back to the low-level atmosphere. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Natural Hazards & Environment (JNHE) / Doğal Afetler ve Çevre Dergisi (DACD) is the property of Artvin Coruh University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hydrogen has become a prospective energy carrier for a cleaner, more sustainable economy, offering carbon-free energy to reduce reliance on fossil fuels and address climate change challenges. However, hydrogen production faces significant technological and economic hurdles that must be overcome to reveal its highest potential. This study focused on evaluating the economics and technoeconomic resilience of two large-scale hydrogen production routes from African palm empty fruit bunches (EFB) by indirect gasification. Computer-aided process engineering (CAPE) assessed multiple scenarios to identify bottlenecks and optimize economic performance indicators like gross profits, including depreciation, after-tax profitability, payback period, and net present value. Resilience for each route was also assessed, considering raw material costs and the market price of hydrogen in relation to gross profits and after-tax profitability. Route 1 achieved a gross profit (DGP) of USD 47.12 million and a profit after taxes (PAT) of USD 28.74 million, while Route 2 achieved a DGP of USD 46.53 million and a PAT of USD 28.38 million. The results indicated that Route 2, involving hydrogen production through an indirect gasification reactor with a Selexol solvent unit for carbon dioxide removal, demonstrated greater resilience in terms of raw material costs and product selling price. [ABSTRACT FROM AUTHOR]

Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells preferentially in the bone marrow. Currently, emerging chemotherapy drugs with improved biosafety profiles, such as immunomodulatory agents and protease inhibitors, have been used in clinics to treat MM in both initial therapy or maintenance therapy post autologous hematopoietic stem cell transplantation (ASCT). We previously discovered that caffeic acid phenethyl ester (CAPE), a water-insoluble natural compound, inhibited the growth of MM cells by inducing oxidative stress. As part of our continuous effort to pursue a less toxic yet more effective therapeutic approach for MM, the objective of this study is to investigate the potential of CAPE for in vivo applications by using magnetic resonance imaging (MRI)-capable superparamagnetic iron oxide nanoparticles (IONP) as carriers. Cyclo (Arg-Gly-Asp-D-Phe-Cys) (RGD) is conjugated to IONP (RGD-IONP/CAPE) to target the overexpressed αvβ3 integrin on MM cells for receptor-mediated internalization and intracellular delivery of CAPE. A stable loading of CAPE on IONP can be achieved with a loading efficiency of 48.7% ± 3.3% (wt%). The drug-release studies indicate RGD-IONP/CAPE is stable at physiological (pH 7.4) and basic pH (pH 9.5) and subject to release of CAPE at acidic pH (pH 5.5) mimicking the tumor and lysosomal condition. RGD-IONP/CAPE causes cytotoxicity specific to human MM RPMI8226, U266, and NCI-H929 cells, but not to normal peripheral blood mononuclear cells (PBMCs), with IC50s of 7.97 ± 1.39, 16.75 ± 1.62, and 24.38 ± 1.71 μM after 72-h treatment, respectively. Apoptosis assays indicate RGD-IONP/CAPE induces apoptosis of RPMI8226 cells through a caspase-9 mediated intrinsic pathway, the same as applying CAPE alone. The apoptogenic effect of RGD-IONP/CAPE was also confirmed on the RPMI8226 cells co-cultured with human bone marrow stromal cells HS-5 in a Transwell model to mimic the MM microenvironment in the bone marrow. In conclusion, we demonstrate that water-insoluble CAPE can be loaded to RGD-IONP to greatly improve the biocompatibility and significantly inhibit the growth of MM cells in vitro through the induction of apoptosis. This study paves the way for investigating the MRI-trackable delivery of CAPE for MM treatment in animal models in the future.

CARD14 (caspase activation and recruitment domain) mutations have been associated with psoriasis vulgaris, psoriatic arthritis, generalized and palmoplantar pustular psoriasis, pityriasis rubra pilaris, and atopic dermatitis. We present a pediatric patient with a novel CARD14: c.394A > T/− (Ile123Phe) mutation, diagnosed with CARD14-associated papulosquamous eruption (CAPE), who was successfully treated with biological treatment.

China has highly emphasized the research and operational application of numerical weather prediction. This paper determines the objective function parameters, such as CAPE and SRH, to apply an ensemble numerical prediction model in weather forecasting. Preprocessing and evaluating rainfall data is necessary to construct the WRF-ARW numerical weather prediction model. The WRF-ARW model is applied to simulate the weather forecasts in Henan Province, and the difficulties and challenges faced in the efficient implementation of the parameterized scheme are outlined. The WRFARW model’s prediction errors for the maximum rainfall and total rainfall in Henan Province range from 1.78%-13.51% and 0.16%-3.78%, respectively, which are significantly less than 15%, and the model is more predictive than the others. The raw data test set’s credibility ranges from 0.957 to 0.997, which is close to 1, indicating that the raw data collected in this paper are highly credible. The WRF-ARW model’s qualification rates for forecasting maximum rainfall and total rainfall are 86.7% and 93.3%, respectively, and its overall accuracy is grade B and grade A, respectively. The pass rates for the peak occurrence time of maximum rainfall and total rainfall were 93.3% and 86.7%, respectively, and the overall prediction accuracy was Grade A and Grade B, respectively. The WRF-ARW model is effective in weather forecasting throughout Henan Province. In summary, the WRF-ARW model is very effective in improving the efficiency of ensemble numerical weather prediction and parameterization schemes in Henan Province.

Southeastern South America (SESA) experienced some of the largest positive trends in total and extreme precipitation of the Southern Hemisphere during the last decades. The City of Buenos Aires, the second largest mega‐city of SESA, has been particularly hard‐hit by these trends due to its flat topography and poor natural drainage. Recent studies suggest that these precipitation extremes may exacerbate even further under global warming, but the physical mechanisms responsible for such events have not been documented for this region so far. This study quantifies the relative contributions of dynamics (atmospheric fronts) and thermodynamics (vertical stability) on the observed variations and trends of daily, seasonal and annual precipitation over the City of Buenos Aires between 1981 and 2020 by splitting the precipitation events into convective and stratiform. Results show that the relative contributions from dynamics and thermodynamics depend on the season under consideration: the positive trends in summer precipitation have been favoured by a net increase in vertical instability with a negligible contribution from dynamics, while the increased frequency of fronts in autumn and winter, when no changes in vertical instability have been observed, has contributed to the higher frequency of cold‐season convective events. [ABSTRACT FROM AUTHOR]

Background: The CAPE Vulnerability Index serves as a worldwide foreign policy indicator that implies which countries should get assistance first. It provides an evidencebased, well-structured, and well-reasoned strategy for employing aid in bilateral arrangements with mental health as a basis. Objective: The second edition of the CAPE VI has been developed to identify which nations should get priority foreign aid. Materials and Methods: We considered various indices or measures at the country level reflecting the average national health status or factors influencing public health. To make our choice, we used 26 internationally accessible and verified indicators. For the study, we have scored the countries according to these indices and prioritized those with the worst scores. Results: The CAPE Vulnerability Index is based on the number of times a country is ranked among the low-scoring nations. It is based on nine parameters and is an independent measure even though there may be a correlation with similar indices such as life expectancy, disability-adjusted life years(DALYs), physician numbers, and gross domestic product(GDP). Conclusion: We concluded that low-scoring countries were fragile or failed states, such as nations where governments lack complete oversight or power, are often oppressive and corrupt, have allegations of violations of human rights, or are marked by political turmoil in different forms, drawbacks from severe environmental damage, severe impoverishment, inequalities, cultural and racial divisions, cannot supply fundamental amenities, are victims of terrorism, and so on. To address these essential problems impacting fragile nations, administrations, aid donors, local organizations, mental health specialists, and associations should collaborate. [ABSTRACT FROM AUTHOR]

Aims: Schizotypy reflects the vulnerability to schizophrenia in the general population. Different questionnaires have been developed to measure aspects of schizotypy. Higher schizotypy scores have also been linked with depression, anxiety, and stress sensitivity. Here we examine the associations of schizotypy with symptoms of depression and anxiety in a sample of university students, using two different measures (N = 271). Methods: A series of confirmatory factor analyses was used to examine two distinct and frequently employed measures of schizotypy: the Community Assessment of Psychic Experiences (CAPE), and the Schizotypy Personality Questionnaire (SPQ). We assessed their relationship with each other and their predictive validity for anxiety, depression, and stress sensitivity. Results: Our results indicated the brief 7‐factor SPQ (SPQ‐BR) factor solution for the SPQ and the 15‐item and 3 factor solution for the CAPE (i.e., CAPE‐P15) as best fitting models. Particularly the CAPE dimension of persecutory ideation was a strong predictor of anxiety, depression, and stress sensitivity, whereas the SPQ dimensions of no close friends and social anxiety predicted psychological distress and stress in our student sample. Conclusions: Our findings extend earlier work in general and patient samples and point to the importance of understanding the contribution of particularly positive schizotypy symptoms and different interpersonal aspects to psychological distress. [ABSTRACT FROM AUTHOR]

Epithelial growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are the first‐line therapy for EGFR mutated non‐small cell lung cancer (NSCLC); however, resistance rapidly develops. The objective of this study was therefore to establish and characterize a gefitinib resistant NSCLC line (HCC827GR) and evaluate the therapeutic effects of natural products in combination with third‐generation EGFR‐TKI, AZD9291. The IC50 of gefitinib and AZD9291 in HCC827GR were significantly higher than those of HCC827 (p < 0.05). Furthermore, anchorage‐independent colony assay indicated that HCC827GR cells were more aggressive than their predecessors. This was reflected by the gene/protein expression changes observed in HCC827GR versus HCC827 profiled by cancer drug resistance real‐time polymerase chain reaction (RT‐PCR) array and Western blot. Three natural products were screened and caffeic acid phenethyl ester (CAPE) exhibited the most significant combinative cytotoxic effect with AZD9291. Specifically, flow cytometry revealed that AZD9291 + CAPE considerably increased the fraction of cell in pre‐G1 of the cell cycle and caspase‐Glo3/7 assay showed a dramatic increase in apoptosis when compared to AZD9291 alone. Furthermore, Western blot showed significant downregulation of p‐EGFR/p‐AKT in HCC827GR cells treated with AZD9291 + CAPE as compared to AZD9291. Moreover, it is evident that AZD9291 + CAPE specifically resulted in a marked reduction in the protein expressions of the cell‐proliferation‐related genes p21, cyclin D1, and survivin. Finally, refined RT‐PCR/Western blot data indicated that AZD9291 + CAPE may at least partially exert its synergistic effects via the PLK2 pathway. Together, these results suggest that CAPE is a clinically relevant compound to aid AZD9291 in treating EGFR‐TKI resistant cells through modulating critical genes/proteins involved in cancer resistance/therapy. [ABSTRACT FROM AUTHOR]

Breast cancer is associated with high morbidity and mortality in women since conventional treatment methods are limited due to toxicity problems and inadequate targeting of cancer cells. The aim of this study is to develop caffeic acid phenethyl ester (CAPE) loaded polymeric nanoparticles to provide treatment for breast cancer and investigate their anti-tumor activity on MCF-7 and MDA-MB-231 breast cancer cells. CAPE was encapsulated into poly lactic-co-glycolic acid (PLGA) polymer using single-emulsion (o/w) solvent evaporation method and characterization of CAPE loaded PLGA nanoparticles (CAPE-NPs) were performed by particle size, zeta potential, polydispersity index , in vitro release profile, and surface morphology. CAPE-NPs were tested for cytotoxicity, anti-migration, anti-proliferation and apoptotic activities on breast cancer cells. The mean nanoparticle size was found as 196,1 ± 8982 nm and polydispersity index (PDI) was 0186 ± 0069. The results of the in vitro cell culture studies indicated that treatment of breast cancer cells with CAPE and CAPE-NPs inhibited cell viability and proliferation. IC 50 values for 48 h were determined as 28.35 μg/ml,19.57 μg/ml for CAPE and CAPE-NP, respectively. Additionally, CAPE-NPs induced intrinsic pathway of apoptosis in MCF-7 and MDA-MB-231 cell lines. Overall, CAPE-NPs showed more efficient anti-tumour activity on breast cancer cells by small size and enhanced bioavability. [Display omitted] • The aim of this study is to develop CAPE-NPs to provide treatment for breast cancer. • CAPE loaded PLGA nanoparticles were produced (CAPE-NPs). • CAPE-NPs anti-tumour activity was evaluated on breast cancer cell lines. • CAPE-NPs exhibited higher cytotoxicity than CAPE due to their small size and controlled release. • CAPE-NPs demonstrated a decrease in cell proliferation and induced the intrinsic pathway of apoptosis. [ABSTRACT FROM AUTHOR]

Squall lines are substantially influenced by the interaction of low‐level shear with cold pools associated with convective downdrafts. Beyond an optimal shear amplitude, squall lines tend to orient themselves at an angle with respect to the low‐level shear. While the mechanisms behind squall line orientation seem to be increasingly well understood, uncertainties remain on the implications of this orientation. Roca and Fiolleau (2020, https://doi.org/10.1038/s43247-020-00015-4) show that long lived mesoscale convective systems, including squall lines, are disproportionately involved in rainfall extremes in the tropics. This article investigates the influence of the interaction between low‐level shear and squall line outflow on squall line generated precipitation extrema in the tropics. Using a cloud resolving model, simulated squall lines in radiative convective equilibrium amid a shear‐dominated regime (super optimal), a balanced regime (optimal), and an outflow dominated regime (suboptimal). Our results show that precipitation extremes in squall lines are 40% more intense in the case of optimal shear and remain 30% superior in the superoptimal regime relative to a disorganized case. With a theoretical scaling of precipitation extremes (C. Muller & Takayabu, 2020, https://doi.org/10.1088/1748-9326/ab7130), we show that the condensation rates control the amplification of precipitation extremes in tropical squall lines, mainly due to its change in vertical mass flux (dynamic component). The reduction of dilution by entrainment explains half of this change, consistent with Mulholland et al. (2021, https://doi.org/10.1175/jas-d-20-0299.1). The other half is explained by increased cloud‐base velocity intensity in optimal and superoptimal squall lines. Plain Language Summary: Squall lines are bands of clouds and thunderstorms spanning hundreds of kilometers, also called quasi‐linear mesoscale convective systems. These systems are associated with extreme weather conditions, including extreme rainfall rates. To better understand and therefore predict this high impact phenomenon, this study investigates the physical processes leading to enhanced precipitation rates when clouds are organized into squall lines, using idealized high‐resolution simulations. Interestingly, the dynamics of squall lines, notably their wind structures, are found to play a key role in setting the intensity of extreme rainfall rates. Key Points: Precipitation extremes are enhanced by about 30%–40% in optimal and superoptimal squall lines compared to random convectionThe enhancement of extremes is due to reduced dilution by entrainment and enhanced initial vertical velocity of updrafts in optimal and superoptimal regimesThe enhanced vertical velocity in convective updrafts does not depend on the orientation of squall lines in the superoptimal regime [ABSTRACT FROM AUTHOR]

The Geography textbook for the 8th grade has been drawn up based on the program of the Ministry of Education, Science, Technology and Innovation, in different years, with the aim that the students acquire geographical knowledge, reinforces this knowledge in everyday life situations, integrating the cause-effect relationships of natural and human phenomena and processes with geographical research methods. According to the content of the curriculum, regional geography and other eco-continents will be taught in the eighth grade, as well as the submission of questions is covered at the end of each topic in the text. This text deals with interesting issues for several continents, countries, and we will analyse the approaches of the authors, the clearest elaboration for the student on the topics and the questions posed to the students with the goal; remembering, understanding, and applying. A special care and attention has been shown to preserve the right ratios between informative and non-formative material, theoretical and factual, historical and contemporary, respecting the scientific and didactic criteria. We will base the research on Bloom's taxonomy, beginning with knowledge, understanding, application, analysis, synthesis and evaluation, with the aim of better reflecting the state, analyse the revised taxonomy and we will also present the students' recollection, understanding and application in everyday life. [ABSTRACT FROM AUTHOR]

Although Africa and Madagascar host numerous endemic plant families and genera, there has been no attempt to use recent phylogenies in order to summarise information on their age or map their distribution and diversity. Here, we list 35 plant lineages endemic to Africa and its islands deemed to be older than 100 Mya, map their distribution, richness, and weighted endemism, and discuss intrinsic and extrinsic factors that may have facilitated their survival. High concentrations of ancient endemic lineages are found in the Cape and more broadly across southern Africa, in the Congolian rainforests, but also in East Africa and Madagascar, these last two areas sharing surprisingly many lineages. Africa and its islands host a highly distinctive assemblage of unique plant lineages, adapted to humid, mesic, dry, and in several cases fire-prone, environments. A better understanding of their history and ecology will facilitate their conservation in a changing climate. [ABSTRACT FROM AUTHOR]

Are convective clouds strengthened by the addition of aerosol particles? We present new theoretical calculations which starkly contrast previous results. Prior foundational work suggested that aerosols strongly invigorate convective cloud updrafts via changes to cold-phase processes. We show that the peak magnitude of invigoration by this mechanism is substantially reduced for cold-based storms. For warm-based storms, the updrafts are weakened, not strengthened, by aerosol-induced changes to cold-phase processes. Our calculations show that if invigoration occurs, it is driven primarily by changes to warm-phase processes and may be largest well before the storm reaches maturity. The calculations are based on a new formulation of the moist adiabatic lapse rate that accounts for freezing, supersaturation, and condensate loading. The results significantly reshape our understanding of the impact of aerosols on convective updrafts.

Aim:Carbon tetrachloride (CCI4) is a volatile organic chemical agent that can cause damage to many tissues. Caffeic acid phenethyl ester (CAPE), which is structurally similar to flavonoids, is an active component of honeybee propolis. CAPE is known for its antitoxic, antioxidant, and anti-inflammatory effects. In this study, we aimed to investigate the effects of CAPE against testicular damage caused by CCI4.Materials and Methods:Twenty-eight Wistar albino rats were divided into 4 groups (n=7) as, Group 1: control (5% ethanol, 1 mL/day/ip), Group 2: olive oil (0.5 mL/day over/ip), Group 3: CCI4 (0.5 mL/kg over/ip), Group 4: CCI4+CAPE (10 μmol/kg/day/ip). Tissue samples collected at the end of the experiment were detected in 10% formaldehyde and embedded in paraffin. Five-micron-thick sections taken from paraffin blocks were stained with hematoxylin-eosin. To evaluate testicular damage, 100 tubules from each section were randomly examined at 20x magnification under a light microscope and classified as intact, atrophic, and degenerated tubules. Sections were examined by using Leica DFC 280 light microscope and Leica Q Win Image Analysis system (Leica Micros Imaging Solutions Ltd. Cambridge, UK).Results:The testicular sections of the control group and the olive oil group had a normal histological appearance. In the CCI4 group, 55.00±4.22% of the seminiferous tubules were intact, 25.00±2.67% were atrophic and 20.00±1.88% were degenerative. In addition, multinucleated giant cells were found in the lumen of some seminiferous tubules. In the CCI4+CAPE group, 72.14±3.91% of the tubules were intact, 16.42±2.10% were atrophic, and 11.42±2.36% were degenerative. While the number of affected tubules significantly increased in the CCI4 group compared to the control group (p

Abstract Squall lines are substantially influenced by the interaction of low‐level shear with cold pools associated with convective downdrafts. Beyond an optimal shear amplitude, squall lines tend to orient themselves at an angle with respect to the low‐level shear. While the mechanisms behind squall line orientation seem to be increasingly well understood, uncertainties remain on the implications of this orientation. Roca and Fiolleau (2020, https://doi.org/10.1038/s43247-020-00015-4) show that long lived mesoscale convective systems, including squall lines, are disproportionately involved in rainfall extremes in the tropics. This article investigates the influence of the interaction between low‐level shear and squall line outflow on squall line generated precipitation extrema in the tropics. Using a cloud resolving model, simulated squall lines in radiative convective equilibrium amid a shear‐dominated regime (super optimal), a balanced regime (optimal), and an outflow dominated regime (suboptimal). Our results show that precipitation extremes in squall lines are 40% more intense in the case of optimal shear and remain 30% superior in the superoptimal regime relative to a disorganized case. With a theoretical scaling of precipitation extremes (C. Muller & Takayabu, 2020, https://doi.org/10.1088/1748-9326/ab7130), we show that the condensation rates control the amplification of precipitation extremes in tropical squall lines, mainly due to its change in vertical mass flux (dynamic component). The reduction of dilution by entrainment explains half of this change, consistent with Mulholland et al. (2021, https://doi.org/10.1175/jas-d-20-0299.1). The other half is explained by increased cloud‐base velocity intensity in optimal and superoptimal squall lines.

The NF-κB-signaling pathway plays a crucial role in cancer progression, including muscle-derived cancers such as rhabdomyosarcoma or sarcoma. Several natural compounds have been studied for their ability to alter NF-κB signaling in these types of cancers. This review paper summarizes the current knowledge on the effects of natural compounds, including curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, and berberine, on NF-κB signaling in muscle-derived cancers. These compounds have been shown to inhibit NF-κB signaling in rhabdomyosarcoma cells through various mechanisms, such as inhibiting the activation of the IKK complex and the NF-κB transcription factor. These findings suggest that natural compounds could be potential therapeutic agents for muscle-derived cancers. However, further research is needed to fully understand their mechanisms of action and potential clinical applications. [ABSTRACT FROM AUTHOR]

Changes in surface water and energy balance can influence weather through interactions between the land and lower atmosphere. In convecting atmospheres, increases in convective available potential energy (CAPE) at the base of the column are driven by surface turbulent fluxes and can lead to precipitation. Using two global satellite datasets, we analyze the impact of surface energy balance partitioning on convective development by tracking CAPE over soil moisture drydowns (interstorms) during the summer, when land–atmosphere coupling is strongest. Our results show that the sign and magnitude of CAPE development during summertime drydowns depends on regional hydroclimate and initial soil moisture content. On average, CAPE increases between precipitation events over humid regions (e.g., the eastern United States) and decreases slightly over arid regions (e.g., the western United States). The soil moisture content at the start of a drydown was found to only impact CAPE evolution over arid regions, leading to greater decreases in CAPE when initial soil moisture content was high. The effect of these factors on CAPE can be explained by their influence principally on surface evaporation, demonstrating the importance of evaporative controls on CAPE and providing a basis for understanding the soil moisture–precipitation relationship, as well as land–atmosphere interaction as a whole. Significance Statement: Land–atmosphere coupling is a long-standing topic with growing interest within the climate and modeling communities. Understanding and characterizing the feedbacks between the land surface and lower atmosphere has important implications for weather and climate prediction. One component of land–atmosphere coupling not yet fully understood is the soil moisture–precipitation relationship. Our work quantifies the land influence on one pathway for precipitation, convection, by tracking the evolution of atmospheric convective energy as soils dry between storms. Using global satellite observations, we find clear spatial and temporal trends that link summertime convective development to soil moisture content and evaporation. Our observational results provide a benchmark for evaluating how well weather and climate models capture the complex coupling between land and atmosphere. [ABSTRACT FROM AUTHOR]

Convective available potential energy (CAPE), a metric associated with severe weather, is expected to increase with warming, but we have lacked a framework that describes its changes in the populated midlatitudes. In the tropics, theory suggests mean CAPE should rise following the Clausius–Clapeyron (C–C) relationship at ∼6%/K. In the heterogeneous midlatitudes, where the mean change is less relevant, we show that CAPE changes are larger and can be well‐described by a simple framework based on moist static energy surplus, which is robust across climate states. This effect is highly general and holds across both high‐resolution nudged regional simulations and free‐running global climate models. The simplicity of this framework means that complex distributional changes in future CAPE can be well‐captured by a simple scaling of present‐day data using only three parameters. Plain Language Summary: Severe thunderstorms cause substantial damage and may become more destructive in the future. Because these events are associated with conditions of high "Convective Available Potential Energy" (CAPE), it is important to understand how CAPE might increase in a future warmer climate. However, existing theories designed for the tropics are not suitable for the U.S. and similar areas. We find that future changes in CAPE are complex and cannot be predicted based on surface temperature alone, but can be explained using three factors: temperature and moisture at the surface and temperature at a higher level. A single simple framework is therefore able to explain CAPE differences between present and future climates, warm and cold regions, and daytime and nighttime. Key Points: Convective available potential energy (CAPE) shows a strong dependence on "moist static energy surplus" and this dependence holds across climate states. These results are robust across modelsShifts in CAPE contours under climate change mean that hotter and/or wetter conditions are required to produce a given CAPEDistributional shifts in future midlatitudes CAPE can be well‐captured given 3 regional mean changes: surface T and RH, and upper‐level T [ABSTRACT FROM AUTHOR]

• Diurnal and seasonal variations of ML features on a long term basis. • Long term decrease in ML height impacted by atmospheric instability changes. • Increasing occurrences of stratiform rain and decrease in convective rain. The present study deals with the variation in height and width of the melting layer (ML) in relation to atmospheric parameters such as near-surface temperature (2 m), zero-degree isotherm height, cloud liquid water content (CLWC), and prevailing instability expressed in terms of convective available potential energy (CAPE) during the pre-monsoon (March-May) and monsoon (June-September) seasons over a tropical location Kolkata (22.57° N, 88.37° E), India. Stratiform rains which are characterized by the presence of ML, are prevalent over Kolkata during both pre-monsoon and monsoon seasons. The ML height is observed to be dependent on the near-surface temperature, zero-degree isotherm height, and atmospheric instability. Again, CLWC controls the melting layer width. Also, the diurnal and seasonal variations of ML height and width have been investigated over the present location. In addition, a long-term change in ML height, zero-degree isotherm altitude, and atmospheric instability (CAPE) have been observed over this location. The decreasing CAPE has been found to be responsible for increasing (decreasing) stratiform (convective) precipitation over the years. [ABSTRACT FROM AUTHOR]

Identifying modes of convection can be useful in both forecasting and research. For example, it allows for potentially different impacts to be determined in forecasting contexts and stratification of model behavior in research contexts. One area where identification could be particularly beneficial is elevated convection. Elevated convection is not routinely examined (outside of an operational environment) within a physical-process perspective in operational numerical weather prediction model evaluation or verification. Using convection-allowing model (CAM) output the characteristics of four elevated convection diagnostics [based on boundary layer, convective available potential energy (CAPE) ratios, downdraft, and inflow layer properties] are examined in operational forecasts during the U.K. Testbed Summer 2021 run at the Met Office. A survey of the practical use of these diagnostics in a simulated operational environment revealed that diagnostics based on CAPE ratios and inflow layer properties were preferred. These diagnostics were the smoothest varying in both space and time. Treating the CAPE ratio and downdraft properties diagnostics as proxies for updrafts and downdrafts, respectively, showed that updrafts were slightly more likely to be resolved than downdrafts. However, a substantial proportion of both are unresolved in current CAMs. Filtering the CAPE ratios by the inflow layer properties led to improved spatial and temporal characteristics, and thus indicates a potentially useful diagnostic for both research and forecasting. Significance Statement: Understanding diagnostics is important to be able to analyze model data. Four diagnostics to identify elevated convection are characterized from kilometer-scale operational forecasts. Diagnosing elevated convection from model data is important as these events are often associated with impactful forecast busts. Therefore, being able to identify how the model is representing these events could lead to model improvements. Two diagnostics were deemed to be of practical use based on current kilometer-scale forecasts: convective available potential energy ratios and inflow layer properties. These diagnostics varied smoothly in space and time. The two diagnostics were combined to produce a filtered diagnostic that could be useful in both research and operations. [ABSTRACT FROM AUTHOR]

CARD14‐associated papulosquamous eruption (CAPE), a spectrum that includes clinical features of psoriasis and pityriasis rubra pilaris (PRP), is associated with activating mutations in the CARD14 gene. Herein we describe the clinical features of a family with CAPE and a novel mutation of CARD14, and highlight ectropion as part of the phenotypic spectrum of CAPE. [ABSTRACT FROM AUTHOR]

CAPE (caffeic acid phenethyl ester) incorporated microspheres formulate and evaluate these microspheres for topical application. In order to achieve the objective firstly various batches of CAPE loaded microspheres were formulated using varying concentrations of ethyl cellulose as the polymeric matrix and solvent evaporation method. All the microsphere formulations were characterized for yield, entrapment efficiency, In-vitro drug release particle size and FTIR studies were also performed to confirm the non-interference of the drug and excipients. The maximum drug release of CAPE over a period of 12 h was obtained in F2 with 71.02 ± 0.64 % drug concentration found in the dissolution medium whereas the minimum release was witnessed for F5 with 56.89 ± 0.47 drug concentration. The formulation F2 was found to be the most appropriate microspheric formulation loaded with CAPE with good yield, drug encapsulation as well as in vitro drug release. It was therefore considered for formulation in the form of gel. All formulation was achieved employing 22 factorial approaches using both the polymer (carbopol 934) and polypropylene glycol at two concentration levels. All formulations loaded with F2 were found to be white and transparent with good homogeneity with pH ranging from 4.92 to 6.1 confirming that the formulations will be compatible to the skin for topical application. On the basis of the results obtained from the study it can be concluded that Carbopol 934 1% w/v and propylene glycol 20% w/v form an excellent combination for development of gel loaded with microsphere of CAPE. [ABSTRACT FROM AUTHOR]

In this study, we analyze various sources of CAPE in the environment and their contributions to its time tendency that will complement forecast models and operational analyses that are relatively temporally (∼1 h) coarse. As a case study, the relative roles of direct insolation and near-surface moisture advection in the recovery CAPE on 31 March 2016 in northern Alabama are examined using VORTEX-Southeast (VORTEX-SE) observations and numerical simulations. In between rounds of nontornadic morning storms and tornadic evening storms, CAPE over the VORTEX-SE domain increased from near zero to at least 500 J kg−1. A timeline of the day's events is provided with a focus on the evolution of the lower levels of the atmosphere. We focus on its responses to solar insolation and moisture advection, which we hypothesize as the main mechanisms behind the recovery of CAPE. Data from the University of Massachusetts S-Band frequency-modulated, continuous-wave (FMCW) radar and NOAA National Severe Storms Laboratory (NSSL) Collaborative Lower Atmospheric Mobile Profiling System (CLAMPS), and high-resolution EnKF analyses from the Advanced Regional Prediction System (ARPS) are used to characterize the boundary layer evolution in the pre-tornadic storm environment. It is found that insolation-driven surface diabatic heating was the primary driver of rapid CAPE recovery on this day. The methodology developed in this case can be applied in other scenarios to diagnose the primary drivers of CAPE development. Significance Statement: The mechanisms by which atmospheric instability recovers can vary widely and are often a source of uncertainty in forecasting. We want to understand how and why the environment destabilized enough to produce an evening tornado following morning storms on 31 March 2016. To do this, we used model data and observations from a collocated radar and profiler. It was found that heating from the sun at the surface was the primary cause of destabilization in the environment. [ABSTRACT FROM AUTHOR]

Background: The CAPE Vulnerability Index serves as a worldwide foreign policy indicator that implies which countries should get assistance first. It provides an evidence-based, well-structured, and well-reasoned strategy for employing aid in bilateral arrangements with mental health as a basis. Objective: The second edition of the CAPE VI has been developed to identify which nations should get priority foreign aid. Materials and Methods: We considered various indices or measures at the country level reflecting the average national health status or factors influencing public health. To make our choice, we used 26 internationally accessible and verified indicators. For the study, we have scored the countries according to these indices and prioritized those with the worst scores. Results: The CAPE Vulnerability Index is based on the number of times a country is ranked among the low-scoring nations. It is based on nine parameters and is an independent measure even though there may be a correlation with similar indices such as life expectancy, disability-adjusted life years(DALYs), physician numbers, and gross domestic product(GDP). Conclusion: We concluded that low-scoring countries were fragile or failed states, such as nations where governments lack complete oversight or power, are often oppressive and corrupt, have allegations of violations of human rights, or are marked by political turmoil in different forms, drawbacks from severe environmental damage, severe impoverishment, inequalities, cultural and racial divisions, cannot supply fundamental amenities, are victims of terrorism, and so on. To address these essential problems impacting fragile nations, administrations, aid donors, local organizations, mental health specialists, and associations should collaborate.