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2. Socioeconomic disparities in changes to preterm birth and stillbirth rates during the first year of the COVID-19 pandemic: a study of 21 European countries.

Author

Zeitlin, Jennifer, Philibert, Marianne, Barros, Henrique, Broeders, Lisa, Cap, Jan, Draušnik, Željka, Engjom, Hilde, Farr, Alex, Fresson, Jeanne, Gatt, Miriam, Gissler, Mika, Heller, Günther, Isakova, Jelena, Källén, Karin, Kyprianou, Theopisti, Loghi, Marzia, Monteath, Kirsten, Mortensen, Laust, Rihs, Tonia, and Sakkeus, Luule

Subjects
RESEARCH funding, PREMATURE infants, PERINATAL death, META-analysis, DESCRIPTIVE statistics, RELATIVE medical risk, PSYCHOLOGY of mothers, QUALITY of life, PARTICIPATION, HEALTH equity, CONFIDENCE intervals, COVID-19 pandemic, SOCIAL classes, EDUCATIONAL attainment
Abstract

Background Despite concerns about worsening pregnancy outcomes resulting from healthcare restrictions, economic difficulties and increased stress during the COVID-19 pandemic, preterm birth (PTB) rates declined in some countries in 2020, while stillbirth rates appeared stable. Like other shocks, the pandemic may have exacerbated existing socioeconomic disparities in pregnancy, but this remains to be established. Our objective was to investigate changes in PTB and stillbirth by socioeconomic status (SES) in European countries. Methods The Euro-Peristat network implemented this study within the Population Health Information Research Infrastructure (PHIRI) project. A common data model was developed to collect aggregated tables from routine birth data for 2015–2020. SES was based on mother's educational level or area-level deprivation/maternal occupation if education was unavailable and harmonized into low, medium and high SES. Country-specific relative risks (RRs) of PTB and stillbirth for March to December 2020, adjusted for linear trends from 2015 to 2019, by SES group were pooled using random effects meta-analysis. Results Twenty-one countries provided data on perinatal outcomes by SES. PTB declined by an average 4% in 2020 {pooled RR: 0.96 [95% confidence intervals (CIs): 0.94–0.97]} with similar estimates across all SES groups. Stillbirths rose by 5% [RR: 1.05 (95% CI: 0.99–1.10)], with increases of between 3 and 6% across the three SES groups, with overlapping confidence limits. Conclusions PTB decreases were similar regardless of SES group, while stillbirth rates rose without marked differences between groups. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Stillbirths: rates, risk factors, and acceleration towards 2030

Author

Flenady, Vicki, Frøen, J Frederik, Kinney, Mary V, de Bernis, Luc, Lawn, Joy E, Blencowe, Hannah, Heazell, Alexander, Leisher, Susannah Hopkins, Azad, Kishwar, Rahman, Anisur, El-Arifeen, Shams, Day, Louise T, Shah, Stacy L, Alam, Shafi, Wangdi, Sonam, Ilboudo, Tinga Fulbert, Zhu, Jun, Liang, Juan, Mu, Yi, Li, Xiaohong, Zhong, Nanbert, Kyprianou, Theopisti, Allvee, Kärt, Gissler, Mika, Zeitlin, Jennifer, Bah, Abdouli, Jawara, Lamin, Waiswa, Peter, Lack, Nicholas, de Maria Herandez, Flor, Shah More, Neena, Nair, Nirmala, Tripathy, Prasanta, Kumar, Rajesh, Newtonraj, Ariarathinam, Kaur, Manmeet, Gupta, Madhu, Varghese, Beena, Isakova, Jelena, Phiri, Tambosi, Hall, Jennifer A, Curteanu, Ala, Manandhar, Dharma, Hukkelhoven, Chantal, Dijs-Elsinga, Joyce, Klungsøyr, Kari, Poppe, Olva, Barros, Henrique, Correia, Sofi, Tsiklauri, Shorena, Cap, Jan, Podmanicka, Zuzana, Szamotulska, Katarzyna, Pattison, Robert, Hassan, Ahmed Ali, Musafi, Aimable, Kujala, Sanni, Bergstrom, Anna, Langhoff -Roos, Jens, Lundqvist, Ellen, Kadobera, Daniel, Costello, Anthony, Colbourn, Tim, Fottrell, Edward, Prost, Audrey, Osrin, David, King, Carina, Neuman, Melissa, Hirst, Jane, Rubayet, Sayed, Smith, Lucy, Manktelow, Bradley N, Draper, Elizabeth S, Amouzou, Agbessi, Mathers, Colin, Hogan, Dan, Qureshi, Zeshan U, Calderwood, Claire, Shiekh, Suhail, Jassir, Fiorella Bianchi, You, Danzhen, McClure, Elizabeth M, Mathai, Matthews, and Cousens, Simon

Published
2016
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6. National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000: a systematic analysis

Author

Zhu, Jun, Liang, Juan, Mu, Yi, Li, Xiaohong, Costello, Anthony, Colbourn, Tim, Fottrell, Edward, Prost, Audrey, Osrin, David, King, Carina, Neuman, Melissa, More, Neena Shah, Azad, Kishwar, Manandhar, Dharma, Nair, Nirmala, Tripathy, Prasanta, Kumar, Rajesh, Newtonraj, Ariarathinam, Kaur, Manmeet, Gupta, Madhu, Dhaliwal, LK, Aggarwal, Neelam, Venkateshashan, Chawla, Deepak, Hurja, Anju, Shivkumar, Poonam, Jain, Manish, Gathwala, Geeta, Nanda, Smiti, Gupta, Shashi, Singal, Sangeeta, Kumar, Raj, Sharma, Sujata, Mohi, Manjit, Minhas, Santish, Prasad, Rajendra, Verma, Suresh, Raina, Neena, Li, Aimable Musafi, Varghese, Beena, Pattison, Robert, Hirst, Jane, Waiswa, Peter, Kadobera, Daniel, Kujala, Sanni, Bergstrom, Anna, Phiri, Tambosi, Hall, Jennifer A, Day, Louise T, Saha, Stacy L, Alam, Shafi Ul, Rahman, Anisur, El-Arifeen, Shams, Rubayet, Sayed, Hassan, Ahmed Ali, Smith, Lucy, Manktelow, Bradley N, Draper, Elizabeth S, Zhong, Nanbert, Langhoff-Roos, Jans, Flenady, Vicki, Allvee, Kärt, Gissler, Mika, Lack, Nicholas, Wangdi, Sonam, Cap, Jan, Podmanicka, Zuzana, Szamotulska, Katarzyna, Hukkelhoven, Chantal, Dijs-Elsinga, Joyce, Kyprianou, Theopisti, Klungsøyr, Kari, Herandez, Flor de Maria, Curteanu, Ala, Barros, Henrique, Correia, Sofia, Tsiklauri, Shorena, Lundqvist, Ellen, Fulbert Ilboudo, Tinga, Bah, Abdouli, Jawara, Lamin, Zeitlin, Jennifer, Isakova, Jelena, Poppe, Olav, Blencowe, Hannah, Cousens, Simon, Jassir, Fiorella Bianchi, Say, Lale, Chou, Doris, Mathers, Colin, Hogan, Dan, Shiekh, Suhail, Qureshi, Zeshan U, You, Danzhen, and Lawn, Joy E

Published
2016
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7. Developing and testing a protocol using a common data model for federated collection and analysis of national perinatal health indicators in Europe

Author

Zeitlin, Jennifer, Philibert, Marianne, Estupiñán-Romero, Francisco, Loghi, Marzia, Sakkeus, Luule, Draušnik, Željka, Alcaide, Adela Recio, Durox, Mélanie, Cap, Jan, Dimnjakovic, Jelena, Misins, Janis, Bernal Delgado, Enrique, Thissen, Martin, and Gissler, Mika

Subjects
maternal, newborn, caesarean delivery, Articles, Birth data, Method Article, national statistics, federated analysis, perinatal, population health indicators
Abstract

Context: International comparisons of the health of mothers and babies provide essential benchmarks for guiding health practice and policy, but statistics are not routinely compiled in a comparable way. These data are especially critical during health emergencies, such as the coronavirus disease (COVID-19) pandemic. The Population Health Information Research Infrastructure (PHIRI) project aimed to promote the exchange of population data in Europe and included a Use Case on perinatal health. Objective: To develop and test a protocol for federated analysis of population birth data in Europe. Methods: The Euro-Peristat network with participants from 31 countries developed a Common Data Model (CDM) and R scripts to exchange and analyse aggregated data on perinatal indicators. Building on recommended Euro-Peristat indicators, complemented by a three-round consensus process, the network specified variables for a CDM and common outputs. The protocol was tested using routine birth data for 2015 to 2020; a survey was conducted assessing data provider experiences and opinions. Results: The CDM included 17 core data items for the testing phase and 18 for a future expanded phase. 28 countries and the four UK nations created individual person-level databases and ran R scripts to produce anonymous aggregate tables. Seven had all core items, 17 had 13-16, while eight had ≤12. Limitations were not having all items in the same database, required for this protocol. Infant death and mode of birth were most frequently missing. Countries took from under a day to several weeks to set up the CDM, after which the protocol was easy and quick to use. Conclusion: This open-source protocol enables rapid production and analysis of perinatal indicators and constitutes a roadmap for a sustainable European information system. It also provides minimum standards for improving national data systems and can be used in other countries to facilitate comparison of perinatal indicators.

Published
2023

8. How do late terminations of pregnancy affect comparisons of stillbirth rates in Europe? Analyses of aggregated routine data from the Euro‐Peristat Project

Author

Blondel, B, Cuttini, M, Hindori‐Mohangoo, AD, Gissler, M, Loghi, M, Prunet, C, Heino, A, Smith, L, van der Pal‐de Bruin, K, Macfarlane, A, Zeitlin, J, Haidinger, Gerald, Alexander, Sophie, Pavlou, Pavlos, Velebil, Petr, Mortensen, Laust Hvas, Sakkeus, Luule, Lack, Nicholas, Antsaklis, Aris, Berbik, István, Ólafsdóttir, Helga Sól, Bonham, Sheelagh, Misins, Janis, Jaselioniene, Jone, Wagener, Yolande, Gatt, Miriam, Nijhuis, Jan, Klungsoyr, Kari, Szamotulska, Katarzyna, Barros, Henrique, Horga, Mihai, Cap, Jan, Tul, Nataša, Bolúmar, Francisco, Gottvall, Karin, and Berrut, Sylvie

Published
2018
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9. Population birth data and pandemic readiness in Europe

Author

Haidinger, Gerald, Klimont, Jeannette, Alexander, Sophie, Zhang, Wei-Hong, Vandervelpen, Ele, Delnord, Marie, Kolarova, Rumyana, Yordanova, Evelin, Rodin, Urelija, Drausnik, Zeljka, Filipovic-Grcic, Boris, Kyprianou, Theopisti, Scoutellas, Vasos, Velebil, Petr, Mortensen, Laust Hvas, Sakkeus, Luule, Abuladze, Liili, Gissler, Mika, Blondel, Beatrice, Deneux-Tharaux, Catherine, Durox, Melanie, Philibert, Marianne, Zeitlin, Jennifer, Fresson, Jeanne, Heller, Guenther, Misselwitz, Bjoern, Antsaklis, Aris, Berbik, Istvan, Olafsdottir, Helga Sol, Kearns, Karen, Sikora, Izabela, Cuttini, Marina, Loghi, Marzia, Donati, Serena, Boldrini, Rosalia, Misins, Janis, Zile, Irisa, Isakova, Jelena, Touvrey-Lecomte, Aline, Billy, Audrey, Couffignal, Sophie, Weber, Guy, Gatt, Miriam, Nijhuis, Jan, Broeders, Lisa, Achterberg, P. W., Hindori-Mohangoo, Ashna, Klungsoyr, Kari, Akerkar, Rupali, Engjom, Hilde, Szamotulska, Katarzyna, Mierzejewska, Ewa, Barros, Henrique, Rodrigues, Carina, Horga, Mihai, Tica, Vlad, Puscasiu, Lucian, Budianu, Mihaela-Alexandra, Cucu, Alexandra, Calomfirescu, Cristian, Cap, Jan, Mandic, Natasa Tul, Verdenik, Ivan, Zurriaga, Oscar, Alcaide, Adela Recio, Jane, Mireia, Vidal, Maria Jose, Kallen, Karin, Nyman, Anastasia, Rihs, Tonia, Macfarlane, Alison, Wood, Rachael, Monteath, Kirsten, Smith, Lucy, Morgan, Siobhan, Hillen, Jennifer, Haidinger, Gerald, Klimont, Jeannette, Alexander, Sophie, Zhang, Wei-Hong, Vandervelpen, Ele, Delnord, Marie, Kolarova, Rumyana, Yordanova, Evelin, Rodin, Urelija, Drausnik, Zeljka, Filipovic-Grcic, Boris, Kyprianou, Theopisti, Scoutellas, Vasos, Velebil, Petr, Mortensen, Laust Hvas, Sakkeus, Luule, Abuladze, Liili, Gissler, Mika, Blondel, Beatrice, Deneux-Tharaux, Catherine, Durox, Melanie, Philibert, Marianne, Zeitlin, Jennifer, Fresson, Jeanne, Heller, Guenther, Misselwitz, Bjoern, Antsaklis, Aris, Berbik, Istvan, Olafsdottir, Helga Sol, Kearns, Karen, Sikora, Izabela, Cuttini, Marina, Loghi, Marzia, Donati, Serena, Boldrini, Rosalia, Misins, Janis, Zile, Irisa, Isakova, Jelena, Touvrey-Lecomte, Aline, Billy, Audrey, Couffignal, Sophie, Weber, Guy, Gatt, Miriam, Nijhuis, Jan, Broeders, Lisa, Achterberg, P. W., Hindori-Mohangoo, Ashna, Klungsoyr, Kari, Akerkar, Rupali, Engjom, Hilde, Szamotulska, Katarzyna, Mierzejewska, Ewa, Barros, Henrique, Rodrigues, Carina, Horga, Mihai, Tica, Vlad, Puscasiu, Lucian, Budianu, Mihaela-Alexandra, Cucu, Alexandra, Calomfirescu, Cristian, Cap, Jan, Mandic, Natasa Tul, Verdenik, Ivan, Zurriaga, Oscar, Alcaide, Adela Recio, Jane, Mireia, Vidal, Maria Jose, Kallen, Karin, Nyman, Anastasia, Rihs, Tonia, Macfarlane, Alison, Wood, Rachael, Monteath, Kirsten, Smith, Lucy, Morgan, Siobhan, and Hillen, Jennifer

Published
2022

11. Population birth data and pandemic readiness in Europe

Author

Haidinger, Gerald Klimont, Jeannette Alexander, Sophie and Zhang, Wei-Hong Vandervelpen, Ele Delnord, Marie Kolarova, Rumyana Yordanova, Evelin Rodin, Urelija Drausnik, Zeljka and Filipovic-Grcic, Boris Kyprianou, Theopisti Scoutellas, Vasos Velebil, Petr Mortensen, Laust Hvas Sakkeus, Luule and Abuladze, Liili Gissler, Mika Blondel, Beatrice and Deneux-Tharaux, Catherine Durox, Melanie Philibert, Marianne and Zeitlin, Jennifer Fresson, Jeanne Heller, Guenther and Misselwitz, Bjoern Antsaklis, Aris Berbik, Istvan and Olafsdottir, Helga Sol Kearns, Karen Sikora, Izabela and Cuttini, Marina Loghi, Marzia Donati, Serena Boldrini, Rosalia Misins, Janis Zile, Irisa Isakova, Jelena and Touvrey-Lecomte, Aline Billy, Audrey Couffignal, Sophie and Weber, Guy Gatt, Miriam Nijhuis, Jan Broeders, Lisa and Achterberg, P. W. Hindori-Mohangoo, Ashna Klungsoyr, Kari and Akerkar, Rupali Engjom, Hilde Szamotulska, Katarzyna and Mierzejewska, Ewa Barros, Henrique Rodrigues, Carina Horga, Mihai Tica, Vlad Puscasiu, Lucian Budianu, Mihaela-Alexandra and Cucu, Alexandra Calomfirescu, Cristian Cap, Jan Mandic, Natasa Tul Verdenik, Ivan Zurriaga, Oscar Alcaide, Adela Recio Jane, Mireia Vidal, Maria Jose Kallen, Karin and Nyman, Anastasia Rihs, Tonia Macfarlane, Alison Wood, Rachael Monteath, Kirsten Smith, Lucy Morgan, Siobhan and Hillen, Jennifer Euro-Peristat Res Network

Published
2022

12. Declines in stillbirth and neonatal mortality rates in Europe between 2004 and 2010: results from the Euro-Peristat project

Author

Zeitlin, Jennifer, Mortensen, Laust, Cuttini, Marina, Lack, Nicholas, Nijhuis, Jan, Haidinger, Gerald, Blondel, Béatrice, Hindori-Mohangoo, Ashna D, Alexander, Sophie, Pavlou, Pavlos, Velebil, Petr, Andersen, Anne-Marie Nybo, Sakkeus, Luule, Gissler, Mika, Antsaklis, Aris, Berbik, István, Ólafsdóttir, Helga Sól, Bonham, Sheelagh, Misins, Janis, Jaselioniene, Jone, Wagener, Yolande, Gatt, Miriam, van der Pal, Karin, Klungsoyr, Kari, Szamotulska, Katarzyna, Barros, Henrique, Horga, Mihai, Cap, Jan, Tul Mandić, Natasa, Bolúmar, Francisco, Gottvall, Karin, Berrut, Sylvie, Macfarlane, Alison, Delnord, Marie, and Hindori-Mohangoo, Ashna

Published
2016
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17. Cytokeratin 8/18‐negative somatotroph pituitary neuroendocrine tumours (PitNETs, adenomas) show variable morphological features and do not represent a clinicopathologically distinct entity

Author

Soukup, Jiri, primary, Cesak, Tomas, additional, Hornychova, Helena, additional, Manethova, Monika, additional, Michnova, Ludmila, additional, Netuka, David, additional, Vitovcova, Barbora, additional, Cap, Jan, additional, Ryska, Ales, additional, and Gabalec, Filip, additional

Published
2021
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21. Producing valid statistics when legislation, culture, and medical practices differ for births at or before the threshold of survival: Report of a European workshop

Author

Smith, L. K. Blondel, B. Zeitlin, J. Haidinger, Gerald and Alexander, Sophie Kolarova, Rumyana Rodin, Urelija and Kyprianou, Theopisti Velebil, Petr Mortensen, Laust Sakkeus, Luule Gissler, Mika Blondel, Beatrice Heller, Guenther and Lack, Nicholas Antsaklis, Aris Berbik, Istvan Olafsdottir, Helga Sol Bonham, Sheelagh Cuttini, Marina Misins, Janis and Isakova, Jelena Wagener, Yolande Gatt, Miriam Nijhuis, Jan and Klungsoyr, Kari Szamotulska, Katarzyna Barros, Henrique and Horga, Mihai Cap, Jan Tul, Natasa Bolumar, Francisco and Gottvall, Karin Kallen, Karin Berrut, Sylvan Riggenbach, Melanie Macfarlane, Alison Zeitlin, Jennifer Delnord, Marie and Durox, Melanie Hindori-Mohangoo, Ashna Euro-Peristat Sci Comm

Published
2020

22. Producing valid statistics when legislation, culture and medical practices differ for births at or before the threshold of survival: report of a European workshop

Author

Smith, Lk, Blondel, B, Zeitlin, J, Haidinger, Gerald, Alexander, Sophie, Rodin, Urelija, Kyprianou, Theopisti, Velebil, Petr, Mortensen, Laust, Sakkeus, Luule, Gissler, Mika, Heller, Günther, Lack, Nicholas, Antsaklis, Aris, Berbik, István, Ólafsdóttir, Helga Sól, Bonham, Sheelagh, Cuttini, Marina, Misins, Janis, Isakova, Jelena, Wagener, Yolande, Gatt, Miriam, Nijhuis, Jan, Szamotulska, Katarzyna, Barros, Henrique, Horga, Mihai, Cap, Jan, Tul, Natasa, Bolúmar, Francisco, Gottvall, Karin, Källén, Karin, Berrut, Sylvan, Riggenbach, Mélanie, Macfarlane, Alison, Delnord, Marie, Durox, Mélanie, Hindori‐Mohangoo, Ashna, Smith, Lk, Blondel, B, Zeitlin, J, Haidinger, Gerald, Alexander, Sophie, Rodin, Urelija, Kyprianou, Theopisti, Velebil, Petr, Mortensen, Laust, Sakkeus, Luule, Gissler, Mika, Heller, Günther, Lack, Nicholas, Antsaklis, Aris, Berbik, István, Ólafsdóttir, Helga Sól, Bonham, Sheelagh, Cuttini, Marina, Misins, Janis, Isakova, Jelena, Wagener, Yolande, Gatt, Miriam, Nijhuis, Jan, Szamotulska, Katarzyna, Barros, Henrique, Horga, Mihai, Cap, Jan, Tul, Natasa, Bolúmar, Francisco, Gottvall, Karin, Källén, Karin, Berrut, Sylvan, Riggenbach, Mélanie, Macfarlane, Alison, Delnord, Marie, Durox, Mélanie, and Hindori‐Mohangoo, Ashna

Published
2020

23. Predictive and prognostic significance of tumour subtype, SSTR1‐5 and e‐cadherin expression in a well‐defined cohort of patients with acromegaly

Author

Soukup, Jiri, primary, Hornychova, Helena, additional, Manethova, Monika, additional, Michalova, Kvetoslava, additional, Michnova, Ludmila, additional, Popovska, Lenka, additional, Skarkova, Veronika, additional, Cesak, Tomas, additional, Netuka, David, additional, Ryska, Ales, additional, Cap, Jan, additional, Hána, Václav, additional, Kršek, Michal, additional, Dvořáková, Eva, additional, Krčma, Michal, additional, Lazurova, Ivica, additional, Olšovská, Věra, additional, Starý, Karel, additional, Vaňuga, Peter, additional, and Gabalec, Filip, additional

Published
2021
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31. Quantifying the burden of stillbirths before 28 weeks of completed gestational age in high-income countries: a population-based study of 19 European countries

Author

Smith, Lucy K, primary, Hindori-Mohangoo, Ashna D, additional, Delnord, Marie, additional, Durox, Mélanie, additional, Szamotulska, Katarzyna, additional, Macfarlane, Alison, additional, Alexander, Sophie, additional, Barros, Henrique, additional, Gissler, Mika, additional, Blondel, Béatrice, additional, Zeitlin, Jennifer, additional, Haidinger, Gerald, additional, Kolarova, Rumyana, additional, Rodin, Urelija, additional, Kyprianou, Theopisti, additional, Velebil, Petr, additional, Mortensen, Laust, additional, Sakkeus, Luule, additional, Heller, Günther, additional, Lack, Nicholas, additional, Antsaklis, Aris, additional, Berbik, István, additional, Sól Ólafsdóttir, Helga, additional, Bonham, Sheelagh, additional, Cuttini, Marina, additional, Misins, Janis, additional, Isakova, Jelena, additional, Wagener, Yolande, additional, Gatt, Miriam, additional, Nijhuis, Jan, additional, Klungsøyr, Kari, additional, Horga, Mihai, additional, Cap, Jan, additional, Tul, Natasa, additional, Bolúmar, Francisco, additional, Gottvall, Karin, additional, Källén, Karin, additional, Berrut, Sylvan, additional, and Riggenbach, Mélanie, additional

Published
2018
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34. Variations in multiple birth rates and impact on perinatal outcomes in Europe

Author

Heino, Anna, Gissler, Mika, Hindori-Mohangoo, Ashna D., Blondel, Béatrice, Klungsøyr, Kari, Verdenik, Ivan, Mierzejewska, Ewa, Velebil, Petr, Ólafsdóttir, Helga Sól, Macfarlane, Alison, Zeitlin, Jennifer, Haidinger, Gerald, Alexander, Sophie, Pavlou, Pavlos, Mortensen, Laust, Sakkeus, Luule, Lack, Nicholas, Antsaklis, Aris, Berbik, Istvan, Bonham, Sheelagh, Cuttini, Marina, Misins, Janis, Jaselioniene, Jone, Wagener, Yolande, Gatt, Miriam, Nijhuis, Jan, van Der Pal, Karin, Klungsoyr, Kari, Szamotulska, Katarzyna, Barros, Henrique, Horga, Mihai, Cap, Jan, Tul Mandić, Natasa, Bolúmar, Francisco, Gottvall, Karin, Berrut, Sylvie, Klimont, Jeannette, Zhang, Wei Hong, Dramaix-Wilmet, Michèle, Van Humbeeck, Mélissa, Leroy, Charlotte, Minsart, Anne Frédérique, Van Leeuw, Virginie, Martens, Evelyne, De Spiegelaere, Myriam, Verkruyssen, Freddy, Willems, Michel, Aelvoet, Willem, Tafforeau, Jean, Hukkelhoven, Chantal, and [ 1 ] THL Natl Inst Hlth & Welf, Helsinki, Finland [ 2 ] TNO, Netherlands Org Appl Sci Res, Dept Child Hlth, Leiden, Netherlands [ 3 ] Anton de Kom Univ Suriname, Fac Med Sci, Dept Publ Hlth, Paramaribo, Surinam [ 4 ] Paris Descartes Univ, Ctr Epidemiol & Biostat U1153, Obstetr Perinatal & Paediat Epidemiol Res Team, INSERM, Paris, France [ 5 ] Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5018 Bergen, Norway [ 6 ] Norwegian Inst Publ Hlth, Med Birth Registry Norway, N-5018 Bergen, Norway [ 7 ] Univ Ljubljana, Med Ctr, Ljubljana 61000, Slovenia [ 8 ] Natl Res Inst Mother & Child, Dept Epidemiol, Warsaw, Poland [ 9 ] Inst Care Mother & Child, Prague, Czech Republic [ 10 ] Landspitali Univ Hosp, Dept Obstet & Gynaecol, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital

Subjects
Maternal Health, Perinatal Death, Psychologie appliquée, lcsh:Medicine, Labor and Delivery, 0302 clinical medicine, Life, Pregnancy, CH - Child Health, Infant Mortality, Medicine and Health Sciences, Birth Rate, lcsh:Science, SAW12, education.field_of_study, 030219 obstetrics & reproductive medicine, Multidisciplinary, Obstetrics, Mortality rate, Gestational age, Obstetrics and Gynecology, Pregnancies, Sciences bio-médicales et agricoles, Stillbirth, Europe, Health, Fetal Mortality, Premature Birth, Female, Pregnancy, Multiple, Biologie, Healthy Living, Maternal Age, Research Article, Adult, medicine.medical_specialty, Death Rates, Population, Preterm Birth, RT, Birth rate, Europe/epidemiology, 03 medical and health sciences, Population Metrics, 030225 pediatrics, medicine, Very Preterm Birth, Humans, Life Science, education, Fetal Death, Demography, Population Biology, business.industry, lcsh:R, Infant, Newborn, Parturition, Infant, Biology and Life Sciences, Neonates, Birth Rates, medicine.disease, Pregnancy Complications, Relative risk, Tvíburar, People and Places, Birth, Women's Health, Multiple birth, Fæðing, lcsh:Q, ELSS - Earth, Life and Social Sciences, Healthy for Life, business, Developmental Biology
Abstract

Objective: Infants from multiple pregnancies have higher rates of preterm birth, stillbirth and neonatal death and differences in multiple birth rates (MBR) exist between countries. We aimed to describe differences in MBR in Europe and to investigate the impact of these differences on adverse perinatal outcomes at a population level. Methods: We used national aggregate birth data on multiple pregnancies, maternal age, gestational age (GA), stillbirth and neonatal death collected in the Euro-Peristat project (29 countries in 2010, N = 5 074 643 births). We also used European Society of Human Reproduction and Embryology (ESHRE) data on assisted conception and single embryo transfer (SET). The impact of MBR on outcomes was studied using meta-analysis techniques with randomeffects models to derive pooled risk ratios (pRR) overall and for four groups of country defined by their MBR. We computed population attributable risks (PAR) for these groups. Results: In 2010, the average MBR was 16.8 per 1000 women giving birth, ranging from 9.1 (Romania) to 26.5 (Cyprus). Compared to singletons, multiples had a nine-fold increased risk (pRR 9.4, 95% Cl 9.1-9.8) of preterm birth (, 0, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

37. Development of a Methodology to Develop Venture Capital Strategies in Applied R&D Networks.

Author

Cap, Jan-Patrick

Subjects
VENTURE capital, BUSINESS networks, RESEARCH & development, INNOVATIONS in business, BUSINESS models
Abstract

The superior question of this paper is how startups and spin-offs can be supported, and one major goal of this work is to give an overview of existing support mechanisms for new ventures. Through the research of affected stakeholders in the technology transfer process, the characteristics of incubation instruments and the development of the Venture Incubation Canvas, it provides an applied knowledge base for decision makers. The reader should get a picture about how different mechanisms help start-ups in various phases of their venture life cycle and have the necessary tools to create a robust and fruitful incubation business model from the beginning on. The abstract information, principles and the use of the model should be applicable in a general way for different projects and innovation (eco) systems. Since the paper aims at being used in projects in the area of R&D networks, it is important to provide knowledge about the process of transferring technologies into the economy and cast a light on the affected stakeholders. Moreover, a literature review about the different dimensions that are used to define start-up support programs is carried out and existing support mechanisms and best practice examples in the global market are examined. Finally, a practical model is introduced in order to simplify the set-up of an incubation mechanism. [ABSTRACT FROM AUTHOR]

Published
2018

38. State of the art Literature Analysis of Innovation Network Management Frameworks.

Author

Cap, Jan-Patrick

Subjects
BUSINESS networks, RESEARCH & development, INNOVATIONS in business, STRATEGIC alliances (Business), BUSINESSPEOPLE
Abstract

Innovation is one of the main topics pushing economic activities today. The procedure to integrate innovation processes, which need a complex research and development (R & D) environment, is a challenge for enterprises to handle by themselves. As a result, innovation networks are one strategic solution for enterprises and other R & D related organizations and institutes, in order to successfully found and integrate innovation processes within their organization. Followed by further challenges regarding the management of innovation networks, the need of specific innovation network management knowledge and skills become a key competence. The following paper gives a state of the art overview of network management frameworks found in the relevant literature. The particular focus of this Paper lies on the management of innovation networks. The (Innovation) network management frameworks (INMF) of different authors were assembled in various literature research processes. Due to the small amount of INMFs discussed in pertinent literature, general network management frameworks that are applicable to examine innovation networks are identified as relevant as well. All frameworks were selected by their capability of presenting precise understanding about management of innovation networks. Further, the paper analyses all identified management frameworks in order to evaluate the competence of each framework implicating its specific characteristics. The analysis contains a description of all as relevant identified frameworks and elaborates their weaknesses and strengths while taking different innovation and enterprise environments into account. The evaluation process was developed for the specific needs of innovation network management and their individual partners. The conclusion of the paper provides a state of the art compilation and analysis of INMFs. The paper also points out the particular lack of research in this field and gives impulses to develop further ideas and specific INMFs. [ABSTRACT FROM AUTHOR]

Published
2018

39. Variations in rates of severe perineal tears and episiotomies in 20 European countries: a study based on routine national data in Euro-Peristat Project

Author

Blondel, Béatrice, Zeitlin, Jennifer, Haidinger, Gerald, Pavlou, Pavlos, Velebil, Petr, Nybo Andersen, Anne Marie, Sakkeus, Luule, Lack, Nicholas, Antsaklis, Aris, Berbik, István, Karlin, Sophie, Ólafsdóttir, Helga Sól, Bonham, Sheelagh, Cuttini, Marina, Misins, Janis, Jaselioniene, Jone, Wagener, Yolande, Gatt, Miriam, Nijhuis, Jan, Klungsoyr, Kari, Szamotulska, Katarzyna, Bjarnadóttir, Ragnheidur Ingibjörg, Barros, Henrique, Horga, Mihai, Cap, Jan, Bolúmar, Francisco, Gottvall, Karin, Berrut, Sylvie, Macfarlane, Alison, Gissler, Mika, Langhoff-Roos, Jens, Novak-Antolič, Živa, Prunet, Caroline, Zhang, Wei Hong, Hindori-Mohangoo, Ashna AD, Blondel, Béatrice, Zeitlin, Jennifer, Haidinger, Gerald, Pavlou, Pavlos, Velebil, Petr, Nybo Andersen, Anne Marie, Sakkeus, Luule, Lack, Nicholas, Antsaklis, Aris, Berbik, István, Karlin, Sophie, Ólafsdóttir, Helga Sól, Bonham, Sheelagh, Cuttini, Marina, Misins, Janis, Jaselioniene, Jone, Wagener, Yolande, Gatt, Miriam, Nijhuis, Jan, Klungsoyr, Kari, Szamotulska, Katarzyna, Bjarnadóttir, Ragnheidur Ingibjörg, Barros, Henrique, Horga, Mihai, Cap, Jan, Bolúmar, Francisco, Gottvall, Karin, Berrut, Sylvie, Macfarlane, Alison, Gissler, Mika, Langhoff-Roos, Jens, Novak-Antolič, Živa, Prunet, Caroline, Zhang, Wei Hong, and Hindori-Mohangoo, Ashna AD

Abstract

Introduction: Rates of severe perineal tears and episiotomies are indicators of obstetrical quality of care, but their use for international comparisons is complicated by difficulties with accurate ascertainment of tears and uncertainties regarding the optimal rate of episiotomies. We compared rates of severe perineal tears and episiotomies in European countries and analysed the association between these two indicators. Material and methods: We used aggregate data from national routine statistics available in the Euro-Peristat project. We compared rates of severe (third- and fourth-degree) tears and episiotomies in 2010 by mode of vaginal delivery (n = 20 countries), and investigated time trends between 2004 and 2010 (n = 9 countries). Statistical associations were assessed with Spearman's ranked correlations (rho). Results: In 2010 in all vaginal deliveries, rates of severe tears ranged from 0.1% in Romania to 4.9% in Iceland, and rates of episiotomies from 3.7% in Denmark to 75.0% in Cyprus. A negative correlation between the rates of episiotomies and severe tears was observed in all deliveries (rho = −0.66; p = 0.001), instrumental deliveries (rho = −0.67; p = 0.002) and non-instrumental deliveries (rho = −0.72; p < 0.001). However there was no relation between time trends of these two indicators (rho = 0.43; p = 0.28). Conclusions: The large variations in severe tears and episiotomies and the negative association between these indicators in 2010 show the importance of improving the assessment and reporting of tears in each country, and evaluating the impact of low episiotomy rates on the perineum., SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published

Published
2016

45. Stillbirths: rates, risk factors, and acceleration towards 2030

Author

Lawn, Joy E, primary, Blencowe, Hannah, additional, Waiswa, Peter, additional, Amouzou, Agbessi, additional, Mathers, Colin, additional, Hogan, Dan, additional, Flenady, Vicki, additional, Frøen, J Frederik, additional, Qureshi, Zeshan U, additional, Calderwood, Claire, additional, Shiekh, Suhail, additional, Jassir, Fiorella Bianchi, additional, You, Danzhen, additional, McClure, Elizabeth M, additional, Mathai, Matthews, additional, Cousens, Simon, additional, Kinney, Mary V, additional, de Bernis, Luc, additional, Lawn, Joy E, additional, Heazell, Alexander, additional, Leisher, Susannah Hopkins, additional, Azad, Kishwar, additional, Rahman, Anisur, additional, El-Arifeen, Shams, additional, Day, Louise T, additional, Shah, Stacy L, additional, Alam, Shafi, additional, Wangdi, Sonam, additional, Ilboudo, Tinga Fulbert, additional, Zhu, Jun, additional, Liang, Juan, additional, Mu, Yi, additional, Li, Xiaohong, additional, Zhong, Nanbert, additional, Kyprianou, Theopisti, additional, Allvee, Kärt, additional, Gissler, Mika, additional, Zeitlin, Jennifer, additional, Bah, Abdouli, additional, Jawara, Lamin, additional, Lack, Nicholas, additional, de Maria Herandez, Flor, additional, Shah More, Neena, additional, Nair, Nirmala, additional, Tripathy, Prasanta, additional, Kumar, Rajesh, additional, Newtonraj, Ariarathinam, additional, Kaur, Manmeet, additional, Gupta, Madhu, additional, Varghese, Beena, additional, Isakova, Jelena, additional, Phiri, Tambosi, additional, Hall, Jennifer A, additional, Curteanu, Ala, additional, Manandhar, Dharma, additional, Hukkelhoven, Chantal, additional, Dijs-Elsinga, Joyce, additional, Klungsøyr, Kari, additional, Poppe, Olva, additional, Barros, Henrique, additional, Correia, Sofi, additional, Tsiklauri, Shorena, additional, Cap, Jan, additional, Podmanicka, Zuzana, additional, Szamotulska, Katarzyna, additional, Pattison, Robert, additional, Hassan, Ahmed Ali, additional, Musafi, Aimable, additional, Kujala, Sanni, additional, Bergstrom, Anna, additional, Langhoff -Roos, Jens, additional, Lundqvist, Ellen, additional, Kadobera, Daniel, additional, Costello, Anthony, additional, Colbourn, Tim, additional, Fottrell, Edward, additional, Prost, Audrey, additional, Osrin, David, additional, King, Carina, additional, Neuman, Melissa, additional, Hirst, Jane, additional, Rubayet, Sayed, additional, Smith, Lucy, additional, Manktelow, Bradley N, additional, and Draper, Elizabeth S, additional

Published
2016
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46. Thyroid Nodules and Carcinoma in Graves Disease

Author

Cap, Jan, Ryska, Ales, Cantalamessa, L., Baldini, M., Orsatti, A., Meroni, L., Amodei, V., and Castagnone, D.

Subjects
Graves' disease -- Complications, Thyroid cancer -- Diagnosis, Health
Published
2000

50. The PRIMARA study: a prospective, descriptive, observational study to review cinacalcet use in patients with primary hyperparathyroidism in clinical practice.

Author

Schwarz, Peter, Body, Jean-Jacques, Cap, Jan, Hofbauer, Lorenz, Farouk, Mourad, Gessl, Alois, Kuhn, Jean-Marc, Marcocci, C, Mattin, Caroline, Muñoz-Torres, Manuel, Payer, Juraj, Van de Ven, Annenienke, Yavropoulou, Maria MP, Selby, Peter, Schwarz, Peter, Body, Jean-Jacques, Cap, Jan, Hofbauer, Lorenz, Farouk, Mourad, Gessl, Alois, Kuhn, Jean-Marc, Marcocci, C, Mattin, Caroline, Muñoz-Torres, Manuel, Payer, Juraj, Van de Ven, Annenienke, Yavropoulou, Maria MP, and Selby, Peter

Abstract

Objective: Medical management of primary hyperparathyroidism (PHPT) is important in patients for whom surgery is inappropriate. We aimed to describe clinical profiles of adults with PHPT receiving cinacalcet. Design: Descriptive, prospective, observational study in hospital and specialist care centres. Methods: For patients with PHPT aged 23-92 years starting cinacalcet for the first time, information was collected on dosing pattern, biochemistry and adverse drug reactions (ADRs). Initial cinacalcet dosage and subsequent dose changes were at the investigator's discretion. Results: Of 303 evaluable patients with pHTP, 134 (44%) had symptoms at diagnosis (mostly bone pain [58] or renal stones [50]). Mean albumin-corrected serum calcium (ACSC) at baseline was 11.4 mg/dL (2.9 mmol/L). Reasons for prescribing cinacalcet included: surgery deemed inappropriate (35%), patient declined surgery (28%), and surgery failed or contraindicated (22%). Mean cinacalcet dose was 43.9 (SD, 15.8) mg/day at treatment start and 51.3 (31.8) mg/day at Month 12; 219 (72%) completed 12 months' treatment. The main reason for cinacalcet discontinuation was parathyroidectomy (40; 13%). At 3, 6 and 12 months from the start of treatment, 63%, 69% and 71% of patients, respectively, had an ACSC of ≤10.3 mg/dL versus 9.9% at baseline. Reductions from baseline in ACSC of ≥1 mg/dL were seen in 56%, 63% and 60% of patients, respectively. ADRs were reported in 81 patients (27%), most commonly nausea. 7.6% of patients discontinued cinacalcet due to ADRs. Conclusions: Calcium reductions of ≥1 mg/dL were observed in 60% of patients 12 months after initiating cinacalcet, without notable safety concerns., info:eu-repo/semantics/published

Published
2014

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