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2. Loss of color pigmentation is maintained at high frequency in a monkey flower population

Author

Twyford, Alexander, Caola, Aaron M, Choudhary, Pratibha, Raina, Ramesh, and Friedman, Jannice

Subjects
genetic variation, anthocyanin, Mimulus guttatus, polymorphism
Abstract

Color polymorphisms have long been of evolutionary interest for their diverse roles, including mate choice, predator avoidance, and pollinator attraction. While color variation is often under strong selection, some taxa demonstrate unexpectedly high frequencies of presumed deleterious color forms. Here we show that a genetic variant underlying complete loss of anthocyanin pigmentation has risen to an unexpectedly high frequency of >0.2 in a natural population of the plant Mimulus guttatus. Decreased expression of MYB5 transcription factor is associated with unpigmented morphs. While the allele was found only in heterozygote adults in the wild, suggesting negative selection, experiments were unable to demonstrate a fitness cost for unpigmented plants, suggesting a cryptic selection pressure in the wild. However, life-history differences among morphs suggests that unpigmented individuals benefit from later flowering and clonal growth. Overall, our study highlights the complex interplay of factors maintaining variation in nature, even for genes of major effect.

Published
2018
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3. Phase II Trial of Combination of Elotuzumab, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Author

Liu, Chia-jen, primary, Ghobrial, Irene M., additional, Bustoros, Mark, additional, Reyes, Kaitlen, additional, Hornburg, Kalvis, additional, Badros, Ashraf Z., additional, Vredenburgh, James J., additional, Boruchov, Adam, additional, Matous, Jeffrey V, additional, Caola, Aaron, additional, Rivotto, Bradley, additional, Savell, Alexandra, additional, Henrick, Patrick, additional, Paba-Prada, Claudia E., additional, Schlossman, Robert L., additional, Laubach, Jacob, additional, Rosenblatt, Jacalyn, additional, Yee, Andrew J, additional, Nadeem, Omar, additional, Maegawa, Rodrigo O., additional, Jakubowiak, Andrzej, additional, Usmani, Saad Z., additional, Bhutani, Manisha, additional, Cappuccio, Joseph, additional, Berrios, Brianna, additional, Noonan, Kimberly, additional, Zavidij, Oksana, additional, Mouhieddine, Tarek H, additional, Boehner, Cody J, additional, Neuse, Carl-Jannes, additional, Salem, Karma Ziad, additional, Reidy, Mairead, additional, Park, Jihye, additional, Agius, Michael, additional, Rahmat, Mahshid, additional, Manier, Salomon, additional, Bhutani, Divaya, additional, Zonder, Jeffrey A, additional, Munshi, Nikhil, additional, Auclair, Daniel, additional, Anderson, Kenneth, additional, and Richardson, Paul, additional

Published
2018
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4. Whole Exome Sequencing and Targeted Sequencing Reveal the Heterogeneity of Genomic Evolution and Mutational Profile in Smoldering Multiple Myeloma

Author

Salem, Karma, primary, Park, Jihye, additional, Freymond, Claudia, additional, Capelletti, Marzia, additional, Huynh, Daisy, additional, Sacco, Antonio, additional, Perilla Glen, Adriana, additional, Caola, Aaron M., additional, Henrick, Patrick, additional, Van Allen, Eliezer, additional, Liu, David, additional, Roccaro, Aldo M., additional, Munshi, Nikhil C, additional, Getz, Gad, additional, Ghobrial, Irene M., additional, and Manier, Salomon, additional

Published
2016
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5. Final Results of a Phase 1/2 Open-Label Study to Assess the Safety, Tolerability and Preliminary Efficacy of Evofosfamide, a Hypoxia-Activated Prodrug, and Dexamethasone with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma

Author

Laubach, Jacob P., primary, Raje, Noopur, additional, Yee, Andrew J., additional, Armand, Philippe, additional, Schlossman, Robert L., additional, Rosenblatt, Jacalyn, additional, Martin, Michael G., additional, Reynolds, Craig, additional, Shain, Kenneth H., additional, Zackon, Ira, additional, Stampleman, Laura V., additional, Lai, Emily, additional, Caola, Aaron M., additional, Cappuccio, Joseph M., additional, Rivotto, Bradley, additional, Reyes, Kaitlen, additional, Savell, Alexandra, additional, Henrick, Patrick, additional, Pearce, Tillman, additional, Handisides, Damian, additional, Kroll, Stew, additional, Anderson, Kenneth C., additional, Richardson, Paul G., additional, and Ghobrial, Irene M., additional

Published
2016
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6. Phase II Trial of Combination of Elotuzumab, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Author

Ghobrial, Irene M., primary, Badros, Ashraf Z, additional, Vredenburgh, James J., additional, Matous, Jeffrey, additional, Caola, Aaron M., additional, Savell, Alexandra, additional, Henrick, Patrick, additional, Paba-Prada, Claudia E., additional, Schlossman, Robert L., additional, Laubach, Jacob P., additional, Rosenblatt, Jacalyn, additional, Yee, Andrew, additional, Wisch, Jeffrey S., additional, Farber, Charles M., additional, Maegawa, Rodrigo O., additional, Usmani, Saad Z, additional, Cappuccio, Joseph, additional, Rivotto, Bradley, additional, Noonan, Kimberly, additional, Reyes, Kaitlen, additional, Munshi, Nikhil C., additional, Anderson, Kenneth C., additional, and Richardson, Paul, additional

Published
2016
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7. Final Results of the Phase I/II Study of Chemosensitization Using the CXCR4 Inhibitor Plerixafor in Combination with Bortezomib in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma

Author

Ghobrial, Irene M., primary, Shain, Kenneth H., additional, Laubach, Jacob, additional, Henrick, Patrick, additional, Vredenburg, James, additional, Crilley, Pamela, additional, Constantine, Michael, additional, Block, Caroline, additional, Basile, Frank G., additional, Cappuccio, Joseph, additional, Azab, Abdel Kareem, additional, Lai, Emily, additional, Caola, Aaron, additional, Banwait, Ranjit, additional, Savell, Alexandra, additional, Munshi, Nikhil C., additional, Paba-Prada, Claudia E., additional, Schlossman, Robert L., additional, Chuma, Stacey, additional, Noonan, Kimberly, additional, Anderson, Kenneth C., additional, and Richardson, Paul G., additional

Published
2015
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8. Next Generation Sequencing Identifies Smoldering Multiple Myeloma Patients with a High Risk of Disease Progression

Author

Bustoros, Mark, Park, Jihye, Salem, Karma Ziad, Liu, Chia-Jen, Capelletti, Marzia, Huynh, Daisy, Tai, Yu-Tzu, Mouhieddine, Tarek H, Freeman, Samuel, Ha, Gavin, Rhoades, Justin, Reed, Sarah, Gydush, Gregory, Rotem, Denisse, Perilla Glen, Adriana, Henrick, Patrick, Caola, Aaron, Rivotto, Bradley, Savell, Alexandra, Noonan, Kimberly, Reyes, Kaitlen, Sacco, Antonio, Boehner, Cody J, Leblebjian, Houry, Liu, David, Morgan, Elizabeth A, Roccaro, Aldo M., Paba-Prada, Claudia, Van Allen, Eliezer, Love, Christopher, Adalsteinsson, Viktor, Laubach, Jacob, Schlossman, Robert, Munshi, Nikhil, Richardson, Paul G, Anderson, Kenneth C, Kumar, Shaji K, Getz, Gad, Ghobrial, Irene M, and Manier, Salomon

Published
2017
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