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Nghiên cứu này phân tích tác động của các nhân tố về đặc điểm sản phẩm (chi phí sở hữu, chất lượng cảm nhận, kiểu dáng thiết kế, thời gian sạc pin), danh tiếng thương hiệu, và ảnh hưởng xã hội đến giá trị cảm nhận, từ đó đánh giá ảnh hưởng của giá trị cảm nhận đến ý định mua xe máy điện của người tiêu dùng tại đồng bằng sông Cửu Long. Kết quả phân tích PLS-SEM (Partial Least Square – Structural Equation Modeling) dữ liệu khảo sát từ 245 người dân cho thấy, chất lượng cảm nhận, kiểu dáng thiết kế, danh tiếng thương hiệu và ảnh hưởng xã hội có tác động tích cực đến giá trị cảm nhận; giá trị cảm nhận thúc đẩy ý định mua xe máy điện. Song, chi phí sở hữu, thời gian sạc pin không ảnh hưởng đến giá trị cảm nhận. Kết quả nghiên cứu đóng góp vào cơ sở học thuật về hành vi người tiêu dùng đối với các phương tiện di chuyển xanh; đề xuất hàm ý quản trị cho các nhà quản lý, nhà sản xuất xe máy điện nhằm thúc đẩy ý định mua xe máy điện của người tiêu dùng.

Nutrition and health education are the main content in physical development education for preschool children. To help children develop some good habits and behaviors in eating and hygiene to prevent disease, teachers can use many teaching resources. This study analyzes the advantages of the story works and directions for using them to integrate nutrition and health education for preschool children. Content analysis method, direct interview method, and operational product research method have been used. The results show that stories that can be used to integrate nutrition education for children in preschool are relatively rich and diverse. Teachers can use these stories to educate children about the habit of maintaining physical hygiene and educating children about hygienic and nutritious eating, thereby improving the quality of care, nurturing and education of children at preschool educational establishments.

The artificial solar saltworks fields of Hon Khoi are important industrial and biodiversity resources in southern Vietnam. Most hypersaline environments in this area are characterized by saturated salinity, nearly neutral pH, intense ultraviolet radiation, elevated temperatures and fast desiccation processes. However, the extremely halophilic prokaryotic communities associated with these stressful environments remain uninvestigated. To fill this gap, a metabarcoding approach was conducted to characterize these communities by comparing them with solar salterns in northern Vietnam as well as with the Italian salterns of Motya and Trapani. Sequencing analyses revealed that the multiple reuses of crystallization ponds apparently create significant perturbations and structural instability in prokaryotic consortia. However, some interesting features were noticed when we examined the diversity of ultra-small prokaryotes belonging to Patescibacteria and DPANN Archaea. Surprisingly, we found at least five deeply branched clades, two from Patescibacteria and three from DPANN Archaea, which seem to be quite specific to the Hon Khoi saltworks field ecosystem and can be considered as a part of biogeographical connotation. Further studies are needed to characterize these uncultivated taxa, to isolate and cultivate them, which will allow us to elucidate their ecological role in these hypersaline habitats and to explore their biotechnological and biomedical potential.

The objective of this study was to evaluate the antagonistic activity of Trichoderma spp. against wild pathogen Fusarium oxysporum F.28.1A, which causes wilt disease on sesame. Twenty-six isolates of Trichoderma spp. isolated from soil samples were tested to control F. oxysporum F.28.1A. Prescreening showed that five isolates were T-02B1, T-18B2, T-20B1, T-28B1, and T-29A1, based on the lowest values of colony radius of F. oxysporum F.28.1A. The selected isolates were identified by their ITS region as T. yunnanense T-02B1, T. lentiforme T-18B2, T. asperellum T-20B1, T. hamatum T-28B1, and T. hamatum T-29A1, with similarities around 96–100%. The isolates selected were able to produce enzymes including chitinase, exo-β-1,3-glucanase, and endo-β-1,3-glucanase at levels of 0.34–0.44, 0.017–0.034, and 0.032–0.121 UI · ml –1, respectively, which were considered to be a mechanism to prevent the growth of F. oxysporum F.28.1A. The isolates tested were applied in soil pots to prevent damage from F. oxysporum F.28.1A as a following experiment. The greenhouse experiment was arranged in a completely randomized design with 10 treatments, including a negative control, application of only F. oxysporum F.28.1A, application of both F. oxysporum F.28.1A and fungicide chemicals, application of both F. oxysporum F.28.1A and Trichoderma spp. DHCT, application of T. yunnanense T-02B1, application of T. lentiforme T-18B2, application of T. asperellum T-20B1, application of T. hamatum T-28B1, application of T. hamatum T-29A1 and a mixture of the five selected isolates of Trichoderma spp. with their total population equal to that in individual strain application. The results showed that the five mixed isolates of Trichoderma had a synergistic effect on the reduction of the disease’s prevalence by 35% compared to the negative control treatment.

BackgroundCritically ill patients often require complex clinical care by highly trained staff within a specialized intensive care unit (ICU) with advanced equipment. There are currently limited data on the costs of critical care in low-and middle-income countries (LMICs). This study aims to investigate the direct-medical costs of key infectious disease (tetanus, sepsis, and dengue) patients admitted to ICU in a hospital in Ho Chi Minh City (HCMC), Vietnam, and explores how the costs and cost drivers can vary between the different diseases.MethodsWe calculated the direct medical costs for patients requiring critical care for tetanus, dengue and sepsis. Costing data (stratified into different cost categories) were extracted from the bills of patients hospitalized to the adult ICU with a dengue, sepsis and tetanus diagnosis that were enrolled in three studies conducted at the Hospital for Tropical Diseases in HCMC from January 2017 to December 2019. The costs were considered from the health sector perspective. The total sample size in this study was 342 patients.ResultsICU care was associated with significant direct medical costs. For patients that did not require mechanical ventilation, the median total ICU cost per patient varied between US$64.40 and US$675 for the different diseases. The costs were higher for patients that required mechanical ventilation, with the median total ICU cost per patient for the different diseases varying between US$2,590 and US$4,250. The main cost drivers varied according to disease and associated severity.ConclusionThis study demonstrates the notable cost of ICU care in Vietnam and in similar LMIC settings. Future studies are needed to further evaluate the costs and economic burden incurred by ICU patients. The data also highlight the importance of evaluating novel critical care interventions that could reduce the costs of ICU care.

BackgroundIdentifying patients at risk of dengue shock syndrome (DSS) is vital for effective healthcare delivery. This can be challenging in endemic settings because of high caseloads and limited resources. Machine learning models trained using clinical data could support decision-making in this context.MethodsWe developed supervised machine learning prediction models using pooled data from adult and paediatric patients hospitalised with dengue. Individuals from 5 prospective clinical studies in Ho Chi Minh City, Vietnam conducted between 12th April 2001 and 30th January 2018 were included. The outcome was onset of dengue shock syndrome during hospitalisation. Data underwent random stratified splitting at 80:20 ratio with the former used only for model development. Ten-fold cross-validation was used for hyperparameter optimisation and confidence intervals derived from percentile bootstrapping. Optimised models were evaluated against the hold-out set.FindingsThe final dataset included 4,131 patients (477 adults and 3,654 children). DSS was experienced by 222 (5.4%) of individuals. Predictors were age, sex, weight, day of illness at hospitalisation, indices of haematocrit and platelets over first 48 hours of admission and before the onset of DSS. An artificial neural network model (ANN) model had best performance with an area under receiver operator curve (AUROC) of 0.83 (95% confidence interval [CI], 0.76-0.85) in predicting DSS. When evaluated against the independent hold-out set this calibrated model exhibited an AUROC of 0.82, specificity of 0.84, sensitivity of 0.66, positive predictive value of 0.18 and negative predictive value of 0.98.InterpretationThe study demonstrates additional insights can be obtained from basic healthcare data, when applied through a machine learning framework. The high negative predictive value could support interventions such as early discharge or ambulatory patient management in this population. Work is underway to incorporate these findings into an electronic clinical decision support system to guide individual patient management.

In Southeast Asia, climate change will potentially have negative consequences for urban transportation infrastructure (UTI). It is necessary to improve the understanding of climate change-associated loss and damage in relation to UTI to ensure the sustainability of existing transportation assets and for prioritizing future investments. However, there is currently limited knowledge on how to practically assess loss and damage for UTI in the context of climate change and then to incorporate appropriate adaptation measures and strategies to future-proof transportation planning. This study presents the results and experiences from assessing climate change-related loss and damage to UTI in six cities of Cambodia, Thailand and Vietnam. One pilot city from each country was selected for assessment by applying NK-GIAS software to determine loss and damage for urban roads. It was found that the six selected cities were highly vulnerable to climate change given their location and exposure to sea-level rise, storm surge, flooding, and salinity intrusion. Through analyses conducted using NK-GIAS software, economic losses for different flood scenarios were determined. The linkage between flooding and road damage was demonstrated, with maximum damage estimations under the most extreme flooding scenario of approximately 20 million USD for Hoi An, 3 million USD for Kampot and 21 million USD for Samut Sakhon, corresponding to water levels of 3.4 m, 4.0 m and 2.7 m respectively. Damage to the road network was identified as a key impact related to climate change. Further research is recommended to develop appropriate damage curves through laboratory analysis, addressing both flood depth and duration, to strengthen the NK-GIAS analyses undertaken in this study.

Độ ổn định phân tán vật liệu graphen trong chất lỏng đóng vai trò rất quan trọng để nâng cao hiệu quả ứng dụng trong nhiều lĩnh vực, như trong chất lỏng nano, vật liệu tổ hợp, lĩnh vực y sinh, v.v. Do kích thước của vật liệu graphen ảnh hưởng lớn đến sự phân tán và độ ổn định của graphene, nên chúng tôi hướng đến cách tiếp cận rất mới là sử dụng phương pháp nghiền bi năng lượng cao nhằm giảm kích thước và tăng diện tích bề mặt riêng cho vật liệu graphen đa lớp (GNPs). Các phép đo bề mặt (FE-SEM), quang phổ Raman, phổ hấp thụ hồng ngoại FTIR, phép đo diện tích bề mặt riêng (BET) được sử dụng để đánh giá các đặc tính vật liệu, khả năng phân tán và độ ổn định phân tán trong chất lỏng của vật liệu GNPs sau khi nghiền. Kết quả cho thấy nghiền bi năng lượng cao là phương pháp rất hiệu quả để nâng cao khả năng phân tán và độ ổn định của vật liệu GNPs trong chất lỏng. Vật liệu GNPs được nghiền trong 5 giờ có kích thước bề mặt 218 nm; diện tích bề mặt là 196,63 m2/g, tăng 555% so với vật liệu graphen ban đầu; độ ổn định phân tán tốt nhất với thế zeta đo được là 29,2 mV.

ObjectiveManagement of multidrug-resistant tuberculosis (MDR-TB) is a significant challenge to the global healthcare system due to the complexity and long duration of the MDR-TB treatment. This study analyzed the safety of patients on longer injectable-based MDR-TB treatment regimens using active pharmacovigilance data.MethodWe conducted an observational, prospective study based on active pharmacovigilance within the national TB program. A total of 659 MDR-TB patients were enrolled and followed up at 9 TB- hospitals in 9 provinces of all 3 regions in Vietnam between 2014 and 2016. Patients received a treatment regimen (standardized or individualized) based on their drug susceptibility test result and their treatment history. Baseline and follow-up information was collected at the start and during treatment. Adverse events (AE) were defined and classified as serious adverse events (SAEs) or otherwise. Multivariate Cox regression following the Iterative Bayesian Model Averaging algorithm was performed to identify factors associated with AE occurrence.ResultsOut of 659 patients assessed, 71.3% experienced at least one AE, and 17.5% suffered at least one SAE. The most common AEs were gastrointestinal disorders (38.5%), arthralgia (34.7%), and psychiatric disorders (30.0%). The proportion of patients with nephrotoxicity and hearing loss or vestibular disorders were 7.4% and 15.2%, respectively. 13.1% of patients required modifications or interruption of one or more drugs. In 77.7% of patients, treatment was completed successfully, while 9.3% lost to follow-up, in 3.0% treatment failed, and 7.4% died. Some significant risk factors for nephrotoxicity included diabetes mellitus (HR = 8.46 [1.91-37.42]), renal dysfunction (HR = 8.46 [1.91-37.42]), alcoholism (HR = 13.28 [5.04-34.99]), and a higher average daily dose of injectable drugs (HR = 1.28 [1.14-1.43]).ConclusionWhile a majority of patients on the longer injectable-based regimens experienced non-serious AEs during MDR-TB treatment, one in six patients experienced at least an SAE. Active TB drug-safety monitoring is useful to understand the safety of MDR-TB treatment and explore the risk factors for toxicity. All-oral, shorter MDR-TB regimens might be able to reduce the inconvenience, discomfort, and toxicity of such regimens and increase adherence and likelihood of successful completion.

Fucosylated chondroitin sulfates (FCSs) FCS-BA and FCS-HS, as well as fucan sulfates (FSs) FS-BA-AT and FS-HS-AT were isolated from the sea cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera, respectively. Purification of the polysaccharides was carried out by anion-exchange chromatography on DEAE-Sephacel column. Structural characterization of polysaccharides was performed in terms of monosaccharide and sulfate content, as well as using a series of non-destructive NMR spectroscopic methods. Both FCSs were shown to contain a chondroitin core [→3)-β-d-GalNAc-(1→4)-β-d-GlcA-(1→]n bearing sulfated fucosyl branches at O-3 of every GlcA residue in the chain. These fucosyl residues were different in pattern of sulfation: FCS-BA contained Fuc2S4S, Fuc3S4S and Fuc4S at a ratio of 1:8:2, while FCS-HS contained these residues at a ratio of 2:2:1. Polysaccharides differed also in content of GalNAc4S6S and GalNAc4S units, the ratios being 14:1 for FCS-BA and 4:1 for FCS-HS. Both FCSs demonstrated significant anticoagulant activity in clotting time assay and potentiated inhibition of thrombin, but not of factor Xa. FS-BA-AT was shown to be a regular linear polymer of 4-linked α-L-fucopyranose 3-sulfate, the structure being confirmed by NMR spectra of desulfated polysaccharide. In spite of considerable sulfate content, FS-BA-AT was practically devoid of anticoagulant activity. FS-HS-AT cannot be purified completely from contamination of some FCS. Its structure was tentatively represented as a mixture of chains identical with FS-BA-AT and other chains built up of randomly sulfated alternating 4- and 3-linked α-L-fucopyranose residues.

Green products are increasingly prevalent in developing countries, however consumers are sometimes perceive their green purchasing decision as risky. The major problem seems to be linked to the greenwashing cases. Despite the fact that, up to now there still have no quantitative paper studying how consumers make judgments and decisions in relation to these risks. This paper applies the theory of planned behavior (TPB) to develop research framework under the circumstance of the green vegetable consumption in Vietnam as a whole in terms of green perceived risk. The present study focuses on 455 Vietnamese consumers who have been working and have experience buying green vegetable. The Exploratory factor analysis (EFA) technique and the Confirmatory factor analysis (CFA) were performed using IBM SPSS and AMOS 23 software. Testing the hypotheses and a structural equation modeling (SEM) method were conducted. This research finds out the answer for the questions of how green perceived risk affects consumer's green purchase intentions under the circumstance of an emerging country. Supported the TPB model this paper provides better predictive power of the nexus between intentions and actual behaviors. Finally, this research provides some useful implications for corporates in the marketing strategy development in accordance with environmental trend. Keywords: Green Perceived Risk, Theory of Planned Behavior, Green Purchase Intentions. JEL Classification: C12, L66, M3. DOI: https://doi.org/10.32479/irmm.7877

Extraction process of Cucumaria frondosa japonica Semper, 1868, which are subspecies of Cucumaria frondosa (Gunnerus, 1767), were studied. It was shown that supercritical carbon dioxide extraction of holothuria was more effective than conventional solvent extraction. Step-by-step extraction with carbon dioxide followed by supercritical extraction with the addition of a co-solvent of ethanol can almost double the yields of extracts of triterpene glycosides, styrenes and carotenoids. Moreover, the fraction of triterpene glycosides practically does not contain colored impurities, in contrast to traditional ethanol extraction. The obtained extracts by HPLC in combination with tandem mass spectrometry (HPLC-MS/MS) identified 15 triterpene glycosides, 18 styrene compounds and 14 carotenoids. Supercritical extraction made it possible to obtain extracts with yields superior to conventional hexane and alcohol extracts. Moreover, such an approach with the use of supercritical fluid extraction (SFE) and subsequent profiling of metabolites can help with the study of holothuria species that are not as well studied.

BACKGROUND:Dengue control programs commonly employ reactive insecticide spraying around houses of reported cases, with the assumption that most dengue virus (DENV) transmission occurs in the home. Focal household transmission has been demonstrated in rural settings, but it is unclear whether this holds true in dense and mobile urban populations. We conducted a prospective study of dengue clustering around households in highly urban Ho Chi Minh City, Vietnam. METHODS:We enrolled 71 index cases with suspected dengue (subsequently classified as 52 dengue cases and 19 non-dengue controls); each initiated the enrollment of a cluster of 25-35 household members and neighbors who were followed up over 14 days. Incident DENV infections in cluster participants were identified by RT-PCR, NS1-ELISA, and/or DENV-IgM/-IgG seroconversion, and recent infections by DENV-IgM positivity at baseline. PRINCIPAL FINDINGS/CONCLUSIONS:There was no excess risk of DENV infection within dengue case clusters during the two-week follow-up, compared to control clusters, but the prevalence of recent DENV infection at baseline was two-fold higher in case clusters than controls (OR 2.3, 95%CI 1.0-5.1, p = 0.05). Prevalence of DENV infection in Aedes aegypti was similar in case and control houses, and low overall (1%). Our findings are broadly consistent with household clustering of dengue risk, but indicate that any clustering is at a short temporal scale rather than sustained chains of localized transmission. This suggests that reactive perifocal insecticide spraying may have a limited impact in this setting.

Abstract Background The global initiative ‘Treatment 2.0’ calls for expanding the evidence base of optimal HIV service delivery models to maximize HIV case detection and retention in care. However limited systematic assessment has been conducted in countries with concentrated HIV epidemic. We aimed to assess HIV service availability and service connectedness in Vietnam. Methods We developed a new analytical framework of the continuum of prevention and care (COPC). Using the framework, we examined HIV service delivery in Vietnam. Specifically, we analyzed HIV service availability including geographical distribution and decentralization and service connectedness across multiple services and dimensions. We then identified system-related strengths and constraints in improving HIV case detection and retention in care. This was accomplished by reviewing related published and unpublished documents including existing service delivery data. Results Identified strengths included: decentralized HIV outpatient clinics that offer comprehensive care at the district level particularly in high HIV burden provinces; functional chronic care management for antiretroviral treatment (ART) with the involvement of people living with HIV and the links to community- and home-based care; HIV testing and counseling integrated into tuberculosis and antenatal care services in districts supported by donor-funded projects, and extensive peer outreach networks that reduce barriers for the most-at-risk populations to access services. Constraints included: fragmented local coordination mechanisms for HIV-related health services; lack of systems to monitor the expansion of HIV outpatient clinics that offer comprehensive care; underdevelopment of pre-ART care; insufficient linkage from HIV testing and counseling to pre-ART care; inadequate access to HIV-related services in districts not supported by donor-funded projects particularly in middle and low burden provinces and in mountainous remote areas; and no systematic monitoring of referral services. Conclusions Our COPC analytical framework was instrumental in identifying system-related strengths and constraints that contribute to HIV case detection and retention in care. The national HIV program plans to strengthen provincial programming by re-defining various service linkages and accelerate the transition from project-based approach to integrated service delivery in line with the ‘Treatment 2.0’ initiative.

Background:  Dengue is a disease of major global importance. While most symptomatic infections are mild, a small proportion of patients progress to severe disease with risk of hypovolaemic shock, organ dysfunction and death.  In the absence of effective antiviral or disease modifying drugs, clinical management is solely reliant on supportive measures. Obesity is a growing problem among young people in Vietnam and is increasingly recognised as an important risk factor for severe dengue, likely due to alterations in host immune and inflammatory pathways. Metformin, a widely used anti-hyperglycaemic agent with excellent safety profile, has demonstrated potential as a dengue therapeutic in vitro and in a retrospective observational study of adult dengue patients with type 2 diabetes.  This study aims to assess the safety and tolerability of metformin treatment in overweight and obese dengue patients, and investigate its effects on several clinical, immunological and virological markers of disease severity. Methods: This open label trial of 120 obese/overweight dengue patients will be performed in two phases, with a metformin dose escalation if no safety concerns arise in phase one. The primary endpoint is identification of clinical and laboratory adverse events.  Sixty overweight and obese dengue patients aged 10-30 years will be enrolled at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam. Participants will complete a 5-day course of metformin therapy and be compared to a non-treated group of 60 age-matched overweight and obese dengue patients. Discussion:  Previously observed antiviral and immunomodulatory effects of metformin make it a promising dengue therapeutic candidate in appropriately selected patients. This study will assess the safety and tolerability of adjunctive metformin in the management of overweight and obese young dengue patients, as well as its effects on markers of viral replication, endothelial dysfunction and host immune responses.  Trial registration: ClinicalTrials.gov: NCT04377451 (May 6 th 2020)., Competing Interests: No competing interests were disclosed., (Copyright: © 2021 Nguyen NM et al.)

Background:  Dengue is a disease of major global importance. While most symptomatic infections are mild, a small proportion of patients progress to severe disease with risk of hypovolaemic shock, organ dysfunction and death.  In the absence of effective antiviral or disease modifying drugs, clinical management is solely reliant on supportive measures. Obesity is a growing problem among young people in Vietnam and is increasingly recognised as an important risk factor for severe dengue, likely due to alterations in host immune and inflammatory pathways. Metformin, a widely used anti-hyperglycaemic agent with excellent safety profile, has demonstrated potential as a dengue therapeutic in vitro and in a retrospective observational study of adult dengue patients with type 2 diabetes.  This study aims to assess the safety and tolerability of metformin treatment in overweight and obese dengue patients, and investigate its effects on several clinical, immunological and virological markers of disease severity. Methods: This open label trial of 120 obese/overweight dengue patients will be performed in two phases, with a metformin dose escalation if no safety concerns arise in phase one. The primary endpoint is identification of clinical and laboratory adverse events.  Sixty overweight and obese dengue patients aged 10-30 years will be enrolled at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam. Participants will complete a 5-day course of metformin therapy and be compared to a non-treated group of 60 age-matched overweight and obese dengue patients. Discussion:  Previously observed antiviral and immunomodulatory effects of metformin make it a promising dengue therapeutic candidate in appropriately selected patients. This study will assess the safety and tolerability of adjunctive metformin in the management of overweight and obese young dengue patients, as well as its effects on markers of viral replication, endothelial dysfunction and host immune responses.  Trial registration: ClinicalTrials.gov: NCT04377451 (May 6 th 2020)., Competing Interests: No competing interests were disclosed., (Copyright: © 2020 Nguyen NM et al.)