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3. Trajectories of Remnant Cholesterol are Associated with Diabetic Foot Ulcer in Adult Patients with Type 2 Diabetes: A Retrospective Cohort Study

Author

Cao B, Li K, Ke J, and Zhao D

Subjects
diabetic foot ulcer, remnant cholesterol, trajectories, type 2 diabetes, Specialties of internal medicine, RC581-951
Abstract

Bin Cao,1,2,&ast; Kun Li,1,2,&ast; Jing Ke,1,2 Dong Zhao1,2 1Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People’s Republic of China; 2Beijing Key Laboratory of Diabetes Research and Care, Beijing, 101149, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jing Ke; Dong Zhao, Email kejing@ccmu.edu.cn; zhaodong@ccmu.edu.cnObjective: This study aimed to investigate the potential association between long-term variations in remnant cholesterol (RC) levels and the development of diabetic foot ulcers (DFU) in participants with type 2 diabetes (T2D).Methods: This was a retrospective cohort study. Variation in RC was assessed by the following metrics: mean, standard deviation (SD), coefficient of variation (CV) and trajectories pattern of RC. To identify RC trajectories, we employed the latent class mixture model. The primary endpoint was the development of DFU, and the time-to-event data were analyzed using Cox regression.Results: A total of 1874 patients with T2D were included, with a median follow-up duration of 4.7 years. Among them, 129 individuals (6.9%) developed DFU. The proportion of DFU was significantly higher in the U-shaped group compared to the median group (P for trend < 0.001). Upon adjustment for confounding variables, the U-shaped trajectory correlated with a higher risk of DFU, demonstrating a hazard ratio (HR) of 2.57 (95% CI, 1.54– 4.27). Subgroup analysis showed the U-shaped trajectory had a higher DFU risk regardless of gender (HR=2.40 and 2.81, respectively), glycemic control (HR=1.89 and 7.41, respectively), smoking (HR=2.36 and 2.93, respectively), or hypertension (HR=2.30 and 2.97, respectively). No association was found between mean, SD and CV of RC and DFU.Conclusion: A U-shape trajectory of RC was independently associated with an elevated risk of DFU among patients with T2D.Keywords: diabetic foot ulcer, remnant cholesterol, trajectories, type 2 diabetes

Published
2024

5. Direct tests of T, CP, CPT symmetries in transitions of neutral K mesons with the KLOE experiment

Author

Babusci, D., Berłowski, M., Bloise, C., Bossi, F., Branchini, P., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., D'Amico, R., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Domenico, A., Diociaiuti, E., Domenici, D., D'Uffizi, A., Fantini, G., Gajos, A., Gamrat, S., Gauzzi, P., Giovannella, S., Graziani, E., Kang, X., Kupść, A., Mandaglio, G., Martini, M., Miscetti, S., Moskal, P., Passeri, A., del Rio, E. Pérez, Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Wiślicki, W., Wolke, M., and Bernabéu, J.

Subjects
High Energy Physics - Experiment
Abstract

Tests of the T, CP and CPT symmetries in the neutral kaon system are performed by the direct comparison of the probabilities of a kaon transition process to its symmetry-conjugate. The exchange of in and out states required for a genuine test involving an anti-unitary transformation implied by time-reversal is implemented exploiting the entanglement of $K^0\bar{K}{}^0$ pairs produced at a $\phi$-factory. A data sample collected by the KLOE experiment at DA$\Phi$NE corresponding to an integrated luminosity of about 1.7 fb$^{-1}$ is analysed to study the $\Delta$t distributions of the $\phi\to K_{S}K_{L}\to \pi^+\pi^- \: \pi^{\pm}e^{\mp}\nu$ and $\phi\to K_{S}K_{L}\to \pi^{\pm}e^{\mp}\nu \: 3\pi^0$ processes, with $\Delta$t the difference of the kaon decay times. A comparison of the measured $\Delta$t distributions in the asymptotic region $\Delta t \gg \tau_{S}$ allows to test for the first time T and CPT symmetries in kaon transitions with a precision of few percent, and to observe CP violation with this novel method., Comment: 26 pages, 10 figures. Minor style corrections applied before journal submission. Sumbmitted to Physics Letters B

Published
2022

6. Measurement of the $K_S \to \pi e \nu$ branching fraction with the KLOE experiment

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., D'Amico, R., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Diociaiuti, E., Domenici, D., D'Uffizi, A., Fantini, G., Gajos, A., Gamrat, S., Gauzzi, P., Giovannella, S., Graziani, E., Kang, X., Kupsc, A., Mandaglio, G., Martini, M., Miscetti, S., Moskal, P., Passeri, A., del Rio, E. Perez, Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment
Abstract

The branching fraction for the decay $K_S \to \pi e \nu$ has been measured with a sample of 300 million $K_S$ mesons produced in $\phi \to K_L K_S$ decays recorded by the KLOE experiment at the DA$\Phi$NE $e^+e^-$ collider. Signal decays are selected by a boosted decision tree built with kinematic variables and time-of-flight measurements. Data control samples of $K_L \to \pi e \nu$ decays are used to evaluate signal selection efficiencies. A fit to the reconstructed electron mass distribution finds 49647$\pm$316 signal events. Normalising to the $K_S \to \pi^+\pi^-$ decay events the result for the branching fraction is $\mathcal{B}(K_S \to \pi e \nu) = (7.211 \pm 0.046_{\rm stat} \pm 0.052_{\rm syst}) \times10^{-4}$. The combination with our previous measurement gives $\mathcal{B}(K_S \to \pi e \nu) = (7.153 \pm 0.037_{\rm stat} \pm 0.043_{\rm syst}) \times10^{-4}$. From this value we derive $f_+(0)|V_{us}| = 0.2170 \pm 0.009$., Comment: arXiv admin note: substantial text overlap with arXiv:1912.05990

Published
2022

7. A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity

Author

Liu M, Cao B, Luo Q, Song Y, Shi Y, Cheng M, Liu K, Mao D, Wang X, and Gong C

Subjects
children, hyperuricemia, body mass index, sex, age, obesity, Specialties of internal medicine, RC581-951
Abstract

Meijuan Liu,1 Bingyan Cao,1 Qipeng Luo,2 Yanning Song,1 Yuting Shi,1 Ming Cheng,1 Kai Liu,1 Di Mao,1 Xinmeng Wang,1 Chunxiu Gong1 1Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of China; 2Department of Pain Medicine, Peking University Third Hospital, Beijing, 100191, People’s Republic of ChinaCorrespondence: Chunxiu Gong, Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, People’s Republic of China, Email chunxiugong@sina.comObjective: To explore the gender-, age-, and weight status-specific prevalence of hyperuricemia (HUA) and its associated risk factors among Chinese children and adolescents with obesity.Methods: A total of 1329 children aged 2– 17 years, who were diagnosed with obesity and hospitalized in our center from January 2016 to December 2022 were recruited. They were divided into mild obesity, moderate obesity, and severe obesity groups. HUA was defined as fasting serum uric acid level > 420 μmol/L for boys and > 360 μmol/L for girls. Multivariate logistic regression analyses were performed to identify risk factors for HUA.Results: The highest proportion of hospitalized obese children was aged 10– 13 years comprising 677 (50.9%) followed by those aged 6– 9 years comprising 348 (26.2%) whereas the least proportion was aged 2– 5 years comprising 76 (5.7%). The above differences in age distribution were still present in subgroup analyses according to weight status. Most hospitalized obese children were boys (64.7%), especially in the severe obesity group (75.0%). The overall estimated prevalence of HUA in obese children was 54.8%. It presented a gradual increase trend over the last 7 years, with more rapidly in boys than in girls. Subgroup analysis by weight status showed that the prevalence of HUA was higher in children with moderate obesity (64.3%) and severe obesity (64.2%) when compared with mild obesity (48.2%) (P all< 0.01). Boys reached a relatively high HUA incidence level (≥ 60%) at age 12, which occurred about 2 years later than in girls (age 10). With 12 years as the cut-off point, a high prevalence of HUA (≥ 60%) was observed in both genders. Multivariable logistic regression analyses showed that boy (OR=2.844, 95% CI 2.024– 3.998), age (OR=1.253, 95% CI 1.155– 1.360), BMI-Z score (OR=2.132, 95% CI 1.438– 3.162), fasting blood glucose (OR=0.907, 95% CI 0.860– 0.956), phosphorus (OR=4.123, 95% CI 2.349– 7.239), alkaline phosphatase (OR=1.002, 95% CI 1.001– 1.004), creatinine (OR=1.067, 95% CI 1.037– 1.098), urea nitrogen (OR=1.193, 95% CI 1.032– 1.378), aspartate aminotransferase (OR=1.016, 95% CI 1.002– 1.030), triglycerides (OR=1.339, 95% CI 1.075– 1.667), and high-density lipoprotein cholesterol (OR=0.381, 95% CI 0.160– 0.910) were independently associated with odds of HUA (P all< 0.05).Conclusion: The prevalence of HUA in Chinese obese children and adolescents is unexpectedly high. Childhood HUA was significantly associated with obesity. Gender and age differences were observed in the association between childhood obesity and HUA. Obese children aged ≥ 12 years should be focused on screening the risk of HUA.Keywords: children, hyperuricemia, body mass index, sex, age, obesity

Published
2024

8. Magneto-Optical Measurements of the Negatively Charged 2$s$ Exciton in WSe$_2$

Author

Sell, J. C., Vannucci, J. R., Suarez-Forero, D. G., Cao, B., Session, D. W., Chuang, H. -J., McCreary, K. M., Rosenberger, M. R., Jonker, B. T., Mittal, S., and Hafezi, M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Monolayer transition metal dichalcogenides host a variety of optically excited quasiparticles species that stem from two-dimensional confinement combined with relatively large carrier effective masses and reduced dielectric screening. The magnetic response of these quasiparticles gives information on their spin and valley configurations, nuanced carrier interactions, and insight into the underlying band structure. Recently, there have been several reports of 2$s$/3$s$ charged excitons in TMDs, but very little is still known about their response to external magnetic fields. Using photoluminescence excitation spectroscopy, we observe the presence of the 2$s$ charged exciton and report for the first time its response to an applied magnetic field. We benchmark this response against the neutral exciton and find that both the 2$s$ neutral and charged excitons exhibit similar behavior with g-factors of g$_{\rm{X_0^{2s}}}$=-5.20$\pm$0.11 and g$_{\rm{X_-^{2s}}}$=-4.98$\pm$0.11, respectively., Comment: J.C. Sell and J.R. Vannucci contributed equally to this work

Published
2022
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10. Precision tests of Quantum Mechanics and CPT symmetry with entangled neutral kaons at KLOE

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., D'Amico, R., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Diociaiuti, E., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E. A., Krzemien, W., Kupsc, A., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Passeri, A., Patera, V., del Rio, E. Perez, Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment
Abstract

The quantum interference between the decays of entangled neutral kaons is studied in the process $\phi\rightarrow K_S K_L \rightarrow\pi^+\pi^-\pi^+\pi^-$, which exhibits the characteristic Einstein--Podolsky--Rosen correlations that prevent both kaons to decay into $\pi^+\pi^-$ at the same time. This constitutes a very powerful tool for testing at the utmost precision the quantum coherence of the entangled kaon pair state, and to search for tiny decoherence and CPT violation effects, which may be justified in a quantum gravity framework. The analysed data sample was collected with the KLOE detector at DA$\Phi$NE, the Frascati $\phi$-factory, and corresponds to an integrated luminosity of about 1.7 fb$^{-1}$, i.e. to about $1.7 \times 10^9$ $\phi\rightarrow K_S K_L$ decays produced. From the fit of the observed $\Delta t$ distribution, being $\Delta t$ the difference of the kaon decay times, the decoherence and CPT violation parameters of various phenomenological models are measured with a largely improved accuracy with respect to previous analyses. The results are consistent with no deviation from quantum mechanics and CPT symmetry, while for some parameters the precision reaches the interesting level at which -- in the most optimistic scenarios -- quantum gravity effects might show up. They provide the most stringent limits up to date on the considered models., Comment: 17 pages 6 figures

Published
2021

11. Predictive Value of Skeletal Muscle Function Test Combined with Climbing Test for Postoperative Cardiopulmonary Complications in Patients with COPD and Concurrent Lung Cancer

Author

He Z, Li H, Cao B, Zan Z, Feng H, Wei Q, and Liu K

Subjects
respiratory muscle function, cardiopulmonary complications, lung cancer surgery, climbing test, Diseases of the respiratory system, RC705-779
Abstract

Zemin He,1 Hong Li,1 Boxiong Cao,1 Ziliang Zan,1 Hao Feng,1 Qiang Wei,1 Keting Liu2 1Department of Thoracic Surgery, The First People’s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chendu, Sichuan Province, People’s Republic of China; 2Department of Neurology, Chengdu Seventh People’s Hospital, Chendu, Sichuan Province, People’s Republic of ChinaCorrespondence: Qiang Wei, Department of Thoracic Surgery, The First People’s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), 120 Chengbei Upper Street, Dongsheng Town, Shuangliu District, Chendu, Sichuan Province, People’s Republic of China, Tel +86 13778533702, Email 993092572@qq.comPurpose: To explore the predictive value of skeletal muscle function measurement combined with stair climbing test for postoperative cardiopulmonary complications in patients with chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC).Patients and Methods: A prospective study was conducted from June 2022 to July 2023 at West China Hospital of Sichuan University, including 335 COPD patients with lung cancer who underwent surgery. The patients were divided into two groups based on the occurrence of postoperative cardiopulmonary complications: the complication group and the non-complication group. The demographic data, including gender, age, smoking history, quadriceps strength, body mass index (BMI), respiratory muscle strength, 6-minute walk test (6MWD), stair climbing test, and preoperative pulmonary function tests, were compared between the two groups. Logistic regression analysis was performed to evaluate the predictive power of each parameter for postoperative cardiopulmonary complications.Results: Among the enrolled patients, 103 (30.7%) developed postoperative cardiopulmonary complications. Significant differences were observed between the two groups in terms of quadriceps strength, respiratory muscle strength, 6MWD, smoking history, stair climbing test, DLCO%, FEV1%, heart rate, oxygen saturation, surgical duration, surgical approach, resection range, and blood loss (P< 0.05). Logistic regression analysis revealed that respiratory muscle strength, quadriceps strength, stair climbing test, FEV1%, DLCO%, ΔHR, ΔSPO2, surgical approach were identified as risk factors for postoperative cardiopulmonary complications in patients with COPD and lung cancer.Conclusion: Skeletal muscle function measurement, stair climbing test, FEV1, surgical approach, and DLCO% can serve as assessment tools for surgical risk in patients with COPD and lung cancer. They can predict the occurrence of postoperative cardiopulmonary complications to a certain extent, providing valuable predictive value for these complications in patients with COPD and NSCLC.Keywords: respiratory muscle function, Cardiopulmonary complications, lung cancer surgery, Climbing test

Published
2023

12. Ultrasound Assessment of the Gastrocnemius Muscle as a Potential Tool for Identifying Sarcopenia in Patients with Type 2 Diabetes

Author

Wei W, Xie C, Cao R, Que Y, Zhong X, Chen Z, Lv F, Kang Q, Lin R, Cao B, Lai X, and Tu M

Subjects
sarcopenia, ultrasound, shear wave elastography, gastrocnemius muscle, t2d, Specialties of internal medicine, RC581-951
Abstract

Wen Wei,1,2,&ast; Chengwen Xie,3,&ast; Ronghua Cao,4,&ast; Yanwen Que,3 Xuejing Zhong,5 Zheyuan Chen,6 Fenyan Lv,6 Qianqian Kang,6 Ruiyu Lin,6 Baozhen Cao,7 Xiaomin Lai,7 Mei Tu1 1Department of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of China; 2Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, People’s Republic of China; 3Department of Ultrasonography, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of China; 4Department of Nuclear Medicine, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of China; 5Department of Science and Education, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of China; 6Department of Endocrinology, Fujian Longyan First Hospital, Fujian Medical University, Fuzhou, 350004, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Mei Tu, Department of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of China, Tel +86 5972958989, Fax +86 5972292374, Email tm13859596628@163.comObjective: This study aims to examine the clinical significance of ultrasound evaluation of the gastrocnemius muscle (GM) in identifying sarcopenia in patients with type 2 diabetes (T2D).Methods: One hundred and fifty-three patients with T2D were included in this study. We measured the appendicular skeletal muscle mass index (ASMI), handgrip strength, and 6-meter walking speed. The US-derived muscle thickness (MT), cross-sectional area (CSA), and shear wave ultrasound elastography (SWE) of GM were also measured. We assessed the correlations between clinical indicators and US features. The model for screening sarcopenia was established using stepwise logistic regression. Stepwise linear regression was used to identify a set of variables that jointly estimated ASMI. The model’s ability to identify sarcopenia and low muscle mass was assessed by receiver operating characteristic (ROC) curve analysis.Results: The prevalence of sarcopenia in this study was 24.2%. The CSA, MT and SWE values of the patients with sarcopenia were lower than those of patients without sarcopenia (all p < 0.05). ASMI was positively correlated with CSA (r = 0.56, p < 0.001) and MT (r = 0.39, p < 0.001). Handgrip strength was positively correlated with CSA (r = 0.45, p < 0.001), MT (r = 0.25, p < 0.001), and SWE (r = 0.26, p = 0.002). A diagnostic model for sarcopenia was established with a sensitivity of 81.1%, specificity of 75.0%, and an area under the curve (AUC) of 0.800. The estimated ASMI equation was developed and found to have a positive correlation with actual ASMI (r = 0.70, p < 0.001). It was also effective in diagnosing low muscle mass, with an AUC of 0.787 for males and 0.783 for females.Conclusion: Ultrasonographic assessment of the gastrocnemius muscle was found to be a useful and convenient method for detecting sarcopenia in patients with T2D.Keywords: sarcopenia, ultrasound, shear wave elastography, gastrocnemius muscle, T2D

Published
2023

15. Association of Hyper-Triglyceridemic Waist Phenotype and Diabetic Vascular Complication in the Chinese Population

Author

Li K, Cao B, Ke J, Yang L, and Zhao D

Subjects
hyper-triglyceridemic waist phenotype, type 2 diabetes mellitus, vascular complication, Specialties of internal medicine, RC581-951
Abstract

Kun Li,1,2,&ast; Bin Cao,1,2,&ast; Jing Ke,1,2 Longyan Yang,1,2 Dong Zhao1,2 1Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People’s Republic of China; 2Beijing Key Laboratory of Diabetes Research and Care, Beijing, 101149, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dong Zhao; Longyan Yang, Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People’s Republic of China, Tel +86-10-69543901, Email zhaodong@ccmu.edu.cn; lingbeiyangstudent@163.comBackground: Diabetic vascular complications are the leading cause of crippling and death of diabetic patients and seriously affect patients’ quality of life. It is essential to control the risk factors contributing to vascular complications in patients with Type 2 diabetes (T2DM). This study aimed to examine the association between hyper-triglyceridemic waist phenotype (HWP) and the risk of vascular complication index of diabetes in T2DM patients.Methods: The participants with type 2 diabetes mellitus in this study registered at the National Metabolic Management Center (MMC) of Beijing Luhe Hospital from June 2017 to June 2021. Data were collected by trained personnel according to the protocol. The questionnaire containing information on demographic characteristics and lifestyle factors (including alcohol drinking and cigarette smoking et al) was administered by trained interviewers. Logistic regression analysis assessing the associations between the hyper-triglyceridemic waist phenotype and vascular complication index of diabetes. In addition, the subgroup analysis was performed by age, sex, HbA1c, hypertension or not, and education level.Results: After data cleaning, a total of 3221 participants with T2DM were enrolled. The median (IQR) duration of diabetes was 47.00 (3.00, 125.00) months. Compared to the participants in the Normal triglycerides level and Normal waist circumference group (NTNW), those in the Elevated triglycerides level and Enlarged waist circumference group (HTGW) have a higher risk of CKD-related vascular complications; the OR of decreased estimated glomerular filtration rate (GFR) and elevated urinary albumin creatinine ratio (UACR) were 2.21 (95% CI:1.32– 3.82) and 2.18 (95% CI:1.69– 2.81), respectively. Moreover, compared to the participants in the NTNW group, the ORs of the decreased ankle-brachial index (ABI) and elevated Brachial-ankle pulse wave velocity (baPWV) were 2.24 (95% CI:1.38– 3.80) and 1.63 (95% CI:1.28– 2.06) in the HTGW group.Conclusion: In summary, there was an association between hyper-triglyceridemic waist phenotype and diabetic vascular complications in the Chinese population.Keywords: hyper-triglyceridemic waist phenotype, type 2 diabetes mellitus, vascular complication

Published
2023

16. Upper limit on the $\eta\to\pi^{+}\pi^{-}$ branching fraction with the KLOE experiment

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E. A., Krzemien, W., Kupsc, A., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Parzych, S., Passeri, A., Patera, V., del Rio, E. Perez, Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment
Abstract

Based on an integrated luminosity of 1.61 fb$^{-1}$ $e^+e^-$ collision data collected with the KLOE detector at DA$\Phi$NE, the Frascati $\phi$-factory, a search for the $P$- and $CP$-violating decay $\eta\to\pi^{+}\pi^{-}$ has been performed. Radiative $\phi\to\eta\gamma$ decay is exploited to access the $\eta$ mesons. No signal is observed in the $\pi^{+}\pi^{-}$ invariant mass spectrum, and the upper limit on the branching fraction at 90\% confidence level is determined to be ${\mathcal B}(\eta\to\pi^{+}\pi^{-})<4.9\times10^{-6}$, which is approximately three times smaller than the previous KLOE result. From the combination of these two measurements we get ${\mathcal B}(\eta\to\pi^{+}\pi^{-}) < 4.4\times10^{-6}$ at 90\% confidence level., Comment: 11 pages, 3 figures

Published
2020
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17. Measurement of the branching fraction for the decay $K_S \to \pi \mu \nu$ with the KLOE detector

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwisnski, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamisnska, D., Kozyrev, E. A., Krzemien, W., Kupsc, A., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Parzych, S., Passeri, A., Patera, V., del Rio, E. Perez, Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wislicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Based on a sample of 300 million $K_S$ mesons produced in $\phi \to K_L K_S$ decays recorded by the KLOE experiment at the DA$\Phi$NE $e^+e^-$ collider we have measured the branching fraction for the decay $K_S \to \pi \mu \nu$. The $K_S$ mesons are identified by the interaction of $K_L$ mesons in the detector. The $K_S \to \pi \mu \nu$ decays are selected by a boosted decision tree built with kinematic variables and by a time-of-flight measurement. Signal efficiencies are evaluated with data control samples of $K_L \to \pi \mu \nu$ decays. A fit to the reconstructed muon mass distribution finds $7223 \pm 180$ signal events. Normalising to the $K_S \to \pi^+ \pi^-$ decay events the result for the branching fraction is $\mathcal{B}(K_S \to \pi \mu \nu) = (4.56 \pm 0.11_{\rm stat} \pm 0.17_{\rm syst})\times10^{-4}$., Comment: 16 pages, 12 figures, Accepted in PLB

Published
2019
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18. Fatigue as a Cause of Professional Dissatisfaction Among Chinese Nurses in Intensive Care Unit During COVID-19 Pandemic

Author

Sun T, Huang XH, Zhang SE, Yin HY, Li QL, Gao L, Li Y, Li L, Cao B, Yang JH, and Liu B

Subjects
icu nurses, fatigue, burnout, job satisfaction, turnover intention, covid-19 pandemic, Public aspects of medicine, RA1-1270
Abstract

Tao Sun,1,&ast; Xian-Hong Huang,1,&ast; Shu-E Zhang,2,&ast; Hong-Yan Yin,3 Qing-Lin Li,2 Lei Gao,2 Ye Li,2 Li Li,4 Bing Cao,5 Jin-Hong Yang,6 Bei Liu7 1Department of Health Policy and Management, School of Public Health, Hangzhou Normal University, Hangzhou, 311121, People’s Republic of China; 2Department of Health Management, School of Health Management, Harbin Medical University, Harbin, 150081, People’s Republic of China; 3Department of Humanities and Social Sciences, Harbin Medical University (Daqing), Daqing, 163319, People’s Republic of China; 4Department of Administration, School of Law, Zhejiang University City College, Hangzhou, 310015, People’s Republic of China; 5Department of Oncology, Weifang People’s Hospital, Weifang, 261000, People’s Republic of China; 6Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, 400715, People’s Republic of China; 7Global Center for Infectious Disease and Policy Research, Peking University, Beijing, 100191, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bei Liu, Global Center for Infectious Disease and Policy Research, Peking University, Beijing, 100191, People’s Republic of China, Email 18827380717@163.comAim: To clarify the mediating role of burnout and the moderating role of turnover intention in the association between fatigue and job satisfaction among Chinese nurses in intensive care units (ICU) during the COVID-19 pandemic.Methods: A cross-sectional survey of fifteen provinces in China was conducted, using an online questionnaire, from December 2020 to January 2021, during the COVID-19 pandemic. A total of 374 ICU nurses (effective response rate: 71.37%) provided sufficient responses. Sociodemographic factors, job demographic factors, fatigue, burnout, job satisfaction, and turnover intention were assessed using questionnaires. General linear modeling (GLM), hierarchical linear regression (HLR) analysis, and generalized additive modeling (GAM) were performed to examine all the considered research hypotheses.Results: Fatigue was found to be negatively and significantly associated with job satisfaction. Moreover, burnout played a partial mediating role and turnover intention played a moderating role in the relationship between fatigue and job satisfaction.Conclusion: Over time, a state of physical and mental exhaustion and work weariness among Chinese ICU nurses potentially results in job burnout and consequently promotes the level of job dissatisfaction. The results also found that turnover intention played a moderating role in the relationship between burnout and job satisfaction. Specific policies could be considered to eliminate nurses’ fatigue and negative attitudes during times of public health emergencies.Keywords: ICU nurses, fatigue, burnout, job satisfaction, turnover intention, COVID-19 pandemic

Published
2023

19. Genetic Characterization Conferred Co-Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis Isolates from Southern Xinjiang, China

Author

Cao B, Mijiti X, Deng LL, Wang Q, Yu JJ, Anwaierjiang A, Qian C, Li M, Fang DA, Jiang Y, Zhao LL, Zhao X, Wan K, Liu H, Li G, and Yuan X

Subjects
cross-resistance, ethionamide, isoniazid, mutation, mycobacterium tuberculosis, Infectious and parasitic diseases, RC109-216
Abstract

Bin Cao,1,2,&ast; Xiaokaiti Mijiti,3,&ast; Le-Le Deng,2,4 Quan Wang,3 Jin-Jie Yu,1,2 Aiketaguli Anwaierjiang,5 Chengyu Qian,2,6 Machao Li,2 Dan-Ang Fang,2,6 Yi Jiang,2 Li-Li Zhao,2 Xiuqin Zhao,2 Kanglin Wan,2 Haican Liu,2 Guilian Li,2 Xiuqin Yuan1 1School of Public Health, University of South China, Hengyang, 421001, People’s Republic of China; 2State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People’s Republic of China; 3The Eighth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, People’s Republic of China; 4National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China; 5College of Xinjiang Uyghur Medicine, Hetian, 848000, People’s Republic of China; 6Wenzhou Key Laboratory of Sanitary Microbiology, Key Laboratory of Laboratory Medicine, Ministry of Education, China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiuqin Yuan; Guilian Li, Email wtjysh@126.com; liguilian@icdc.cnBackground: Ethionamide (ETH), a structural analogue of isoniazid (INH), is used for treating multidrug-resistant tuberculosis (MDR-TB). Due to the common target InhA, INH and ETH showed cross-resistance in M. tuberculosis. This study aimed to explore the INH and ETH resistant profiles and genetic mutations conferring independent INH- or ETH-resistance and INH-ETH cross-resistance in M. tuberculosis circulating in south of Xinjiang, China.Methods: From Sep 2017 to Dec 2018, 312 isolates were included using drug susceptibility testing (DST), spoligotyping, and whole genome sequencing (WGS) to analyze the resistance characteristics for INH and/or ETH.Results: Among the 312 isolates, 185 (58.3%) and 127 (40.7%) belonged to the Beijing family and non-Beijing family, respectively; 90 (28.9%) were INH-resistant (INHR) with mutation rates of 74.4% in katG, 13.3% in inhA and its promoter, 11.1% in ahpC and its upstream region, 2.2% in ndh, 0.0% in mshA, whilst 34 (10.9%) were ETH-resistant (ETHR) with mutation rates of 38.2% in ethA, 26.2% in inhA and its promoter, and 5.9% in ndh, 0.0% in ethR or mshA; and 25 (8.0%) were INH-ETH co-resistant (INHRETHR) with mutation rates of 40.0% in inhA and its promoter, and 8% in ndh. katG mutants tended to display high-level resistant to INH; and more inhA and its promoter mutants showed low-level of INH and ETH resistance. The optimal gene combinations by WGS for the prediction of INHR, ETHR, and INHRETHR were, respectively, katG+inhA and its promoter (sensitivity: 81.11%, specificity: 90.54%), ethA+inhA and its promoter+ndh (sensitivity: 61.76%, specificity: 76.62%), and inhA and its promoter+ndh (sensitivity: 48.00%, specificity: 97.65%).Conclusion: This study revealed the high diversity of genetic mutations conferring INH and/or ETH resistance among M. tuberculosis isolates, which would facilitate the study on INHR and/or ETHR mechanisms and provide clues for choosing ETH for MDR treatment and molecular DST methods in south of Xinjiang, China.Keywords: cross-resistance, ethionamide, isoniazid, mutation, Mycobacterium tuberculosis

Published
2023

20. A Bibliometric Analysis of Urologic Chronic Pelvic Pain Syndrome From 2000 to 2022

Author

Wang J, Cao B, Lin S, Wang Y, Zhang Q, Jiang Y, Li W, and Zhu Y

Subjects
bibliometric analysis, chronic pelvic pain syndrome, interstitial cystitis, chronic prostatitis, mechanisms, treatments, Medicine (General), R5-920
Abstract

Jie Wang,&ast; Bin Cao,&ast; Sihao Lin, Yong Wang, Qifa Zhang, Yang Jiang, Wei Li, Yingjian Zhu Department of Urology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201803, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yingjian Zhu; Wei Li, Department of Urology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, People’s Republic of China, Tel +8613764490868 ; +8618117094957, Email zhuyingjian_sjtu@126.com; croma_shh@126.comPurpose: Urologic chronic pelvic pain syndrome has attracted a lot of attention in the new century, and an increasing number of relevant studies have been published. Therefore, we performed a bibliometric analysis of these publications, hoping to show the current research hotspots and future research trends.Methods: The articles on were selected from the Web of Science Core Collection. Countries, authors, references and keywords in the field were visualized and analyzed using CiteSpace and VOSViewer software.Results: A total of 1014 articles on urologic chronic pelvic pain syndrome were identified, with “chronic pelvic pain syndrome” being the most common keyword, with a strong association with “interstitial cystitis” and “chronic prostatitis”. The hotspot of urologic chronic pelvic pain syndrome research has gradually shifted from chronic prostatitis / urologic chronic pelvic pain syndrome to cystitis/bladder pain syndrome over the past few years. Future research tends to focus on urologic chronic pelvic pain syndrome etiology, including oxidative stress and inflammation.Conclusion: Research on urologic chronic pelvic pain syndrome is steadily growing. The United States has made the most prominent contribution in this area, and the share of China’s contribution is expected to grow further. The etiology of urologic chronic pelvic pain syndrome, including inflammation and oxidative stress, have been the focus of current research and developmental trends in the future research.Keywords: bibliometric analysis, chronic pelvic pain syndrome, interstitial cystitis, chronic prostatitis, mechanisms, treatments

Published
2023

21. Molecular Epidemiology of Clinical Mycobacterium tuberculosis Isolates from Southern Xinjiang, China Using Spoligotyping and 15-Locus MIRU-VNTR Typing

Author

Yin C, Mijiti X, Liu H, Wang Q, Cao B, Anwaierjiang A, Li M, Liu M, Jiang Y, Xu M, Wan K, Zhao X, Li G, and Xiao H

Subjects
miru-vntr, spoligotyping, beijing genotype, drug resistance, genetic diversity, mycobacterium tuberculosis., Infectious and parasitic diseases, RC109-216
Abstract

Chunjie Yin,1,&ast; Xiaokaiti Mijiti,2,&ast; Haican Liu,3,&ast; Quan Wang,2 Bin Cao,3,4 Aiketaguli Anwaierjiang,5 Machao Li,3 Mengwen Liu,1 Yi Jiang,3 Miao Xu,2 Kanglin Wan,3 Xiuqin Zhao,3 Guilian Li,3 Hui Xiao1 1School of Public Health, Xinjiang Medical University, Urumqi, People’s Republic of China; 2The Eighth Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China; 3State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China; 4School of Public Health, University of South China, Hengyang, People’s Republic of China; 5College of Xinjiang Uyghur Medicine, Hetian, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guilian Li; Hui Xiao, Email liguilian@icdc.cn; xh20108262@sina.comBackground: In the last decades, the molecular epidemiological investigation of Mycobacterium tuberculosis has significantly increased our understanding of tuberculosis epidemiology. However, few such studies have been done in southern Xinjiang, China. We aimed to clarify the molecular epidemic characteristics and their association with drug resistance in the M. tuberculosis isolates circulating in this area.Methods: A total of 347 isolates obtained from southern Xinjiang, China between Sep, 2017 and Sep, 2019 were included to characterize using a 15-locus MIRU-VNTR (VNTR-15China) typing and spoligotyping, and test for drug susceptibility profiles. Then the lineages and clustering of the isolates were analyzed, as well as their association with drug resistance.Results: Spoligotyping results showed that 60 spoligotype international types (SITs) containing 35 predefined SITs and 25 Orphan or New patterns, and 12 definite genotypes were found, and the top three prevalent genotypes were Beijing genotype (207, 59.7%), followed by CAS1-Delhi (46, 13.6%), and Ural-2 (30, 8.6%). The prevalence of Beijing genotype infection in the younger age group (≤ 30) was more frequent than the two older groups (30~59 and ≥ 60 years old, both P values < 0.05). The Beijing genotype showed significantly higher prevalence of resistance to isoniazid, rifampicin, ethambutol, multi-drug or at least one drug than the non-Beijing genotype (All P values ≤ 0.05). The estimated proportion of tuberculosis cases due to transmission was 18.4% according to the cluster rate acquired by VNTR-15China typing, and the Beijing genotype was the risk factor for the clustering (OR 9.15, 95% CI: 4.18– 20.05).Conclusion: Our data demonstrated that the Beijing genotype is the dominant lineage, associated with drug resistance, and was more likely to infect young people and contributed to tuberculosis transmission in southern Xinjiang, China. These findings will contribute to a better understanding of tuberculosis epidemiology in this area.Keywords: MIRU-VNTR, spoligotyping, Beijing genotype, drug resistance, genetic diversity, Mycobacterium tuberculosis

Published
2023

23. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author

Schweiker, M, André, M, Al-Atrash, F, Al-Khatri, H, Alprianti, RR, Alsaad, H, Amin, R, Ampatzi, E, Arsano, AY, Azar, E, Bannazadeh, B, Batagarawa, A, Becker, S, Buonocore, C, Cao, B, Choi, JH, Chun, C, Daanen, H, Damiati, SA, Daniel, L, De Vecchi, R, Dhaka, S, Domínguez-Amarillo, S, Dudkiewicz, E, Edappilly, LP, Fernández-Agüera, J, Folkerts, M, Frijns, A, Gaona, G, Garg, V, Gauthier, S, Jabbari, SG, Harimi, D, Hellwig, RT, Huebner, GM, Jin, Q, Jowkar, M, Kim, J, King, N, Kingma, B, Koerniawan, MD, Kolarik, J, Kumar, S, Kwok, A, Lamberts, R, Laska, M, Lee, MCJ, Lee, Y, Lindermayr, V, Mahaki, M, Marcel-Okafor, U, Marín-Restrepo, L, Marquardsen, A, Martellotta, F, Mathur, J, Mino-Rodriguez, I, Montazami, A, Mou, D, Moujalled, B, Nakajima, M, Ng, E, Okafor, M, Olweny, M, Ouyang, W, Papst de Abreu, AL, Pérez-Fargallo, A, Rajapaksha, I, Ramos, G, Rashid, S, Reinhart, CF, Rivera, MI, Salmanzadeh, M, Schakib-Ekbatan, K, Schiavon, S, Shooshtarian, S, Shukuya, M, Soebarto, V, Suhendri, S, Tahsildoost, M, Tartarini, F, Teli, D, Tewari, P, Thapa, S, Trebilcock, M, Trojan, J, Tukur, RB, Voelker, C, Yam, Y, Yang, L, Zapata-Lancaster, G, Zhai, Y, Zhu, Y, and Zomorodian, ZS

Subjects
Thermal comfort, Thermal sensation, Thermal acceptance, Field study, Scales, Post-Occupancy-Evaluation: Climatic zone, Season, Language, Adaptation, Diversity, Building & Construction, Engineering, Built Environment and Design
Abstract

People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.

Published
2020

24. A Nomogram for Predicting Vision-Threatening Diabetic Retinopathy Among Mild Diabetic Retinopathy Patients: A Case–Control and Prospective Study of Type 2 Diabetes

Author

Ke J, Li K, and Cao B

Subjects
nomogram, diabetic retinopathy, type 2 diabetes mellitus, prediction, progression, Specialties of internal medicine, RC581-951
Abstract

Jing Ke,1,2 Kun Li,1,2 Bin Cao1,2 1Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People’s Republic of China; 2Beijing Key Laboratory of Diabetes Research and Care, Beijing, 101149, People’s Republic of ChinaCorrespondence: Bin Cao, Tel +86-10-6954-3901, Email dor_caobin666@163.comAim: This study aims to develop a nomogram for predicting vision-threatening diabetic retinopathy (VTDR) in type 2 diabetes mellitus (T2DM) with mild non-proliferative diabetic retinopathy (NPDR) patients.Materials and Methods: In case–control analysis, 440 patients with mild NPDR or VTDR were enrolled to identify predictors and develop a nomogram. In the prospective cohort, 120 T2DM patients with mild NPDR were enrolled for external validation. Sensitivity, specificity, and area under the receiver operating characteristic (AUC) were calculated to evaluate the predictive performance of the nomogram.Results: In case–control analysis, 2-h C-peptide (OR = 0.85, 95% CI: 0.75 to 0.95, p = 0.006), sural nerve conduction impaired (SNCI) (mildly: OR = 2.18, 95% CI: 1.10 to 4.33, p = 0.026; moderately/severely: 3.66, 95% CI: 1.74 to 7.70, p < 0.001) and UACR (microalbuminuria: OR = 2.37, 95% CI: 1.25 to 4.48, p = 0.008; macroalbuminuria: 4.02, 95% CI: 1.61 to 10.06, p = 0.003) were identified as independent predictors. The concordance index of the prediction nomogram was 0.76 in the training set. In the test set, sensitivity, specificity, and AUC were 84.8%, 60.6%, and 0.73, respectively. In the prospective cohort, median follow-up period was 42 months, and 15 patients (12.5%) developed VTDR. Sensitivity, specificity, and AUC of prediction were 66.7%, 89.5%, and 0.75, respectively.Conclusion: Introducing 2-h C-peptide, UACR, and SNCI, the nomogram demonstrated a good discriminatory power for predicting risk of VTDR in mild NPDR individuals.Keywords: nomogram, diabetic retinopathy, type 2 diabetes mellitus, prediction, progression

Published
2023

26. Contributors

Author

Ali, Nasir, primary, Andrijauskas, Fabio, additional, Balakrishna Pillai, P., additional, Banash, Mark, additional, Cao, B., additional, Caracciolo, Dominic, additional, Casimir, Daniel, additional, Chen, J., additional, Ciobanu, Cristian V., additional, Coluci, Vitor R., additional, Dantas, Sócrates O., additional, De Souza, M.M., additional, Farinre, Olasunbo, additional, Garboczi, E.J., additional, Garcia-Sanchez, Raul, additional, Harbola, M.K., additional, Hu, Ming, additional, Ikuhara, Y.H., additional, Ji, Z., additional, Likith, Sri Ranga Jai, additional, Lin, Miao-Ling, additional, Lindsay, L., additional, Lu, Aolin, additional, Mansfield, Elisabeth, additional, Misra, Prabhakar, additional, Mookerjee, A., additional, Myers, J., additional, Pal, Antardipan, additional, Pandey, Ravindra, additional, Pandey, T., additional, Phillips, Lia, additional, Rast, L., additional, Robinson, Richard, additional, Saikia, Nabanita, additional, Shan, Shiyao, additional, Shang, Guojun, additional, Singh, P., additional, Tan, Ping-Heng, additional, Tewary, Vinod K., additional, Vishal, K., additional, Wang, K., additional, Wang, Shan, additional, Wang, Xiaoyu, additional, Wu, Huizhen, additional, Yau, Dennis D., additional, Yu, Shuguo, additional, Yue, Naili, additional, Zhang, Hongyan, additional, Zhang, Yong, additional, Zheng, Zhi, additional, Zhong, Chuan-Jian, additional, Zhou, Weilie, additional, and Zhuang, Y., additional

Published
2023
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27. Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author

Steinmetz, J, Seeher, K, Schiess, N, Nichols, E, Cao, B, Servili, C, Cavallera, V, Cousin, E, Hagins, H, Moberg, M, Mehlman, M, Abate, Y, Abbas, J, Abbasi, M, Abbasian, M, Abbastabar, H, Abdelmasseh, M, Abdollahi, M, Abdollahifar, M, Abd-Rabu, R, Abdulah, D, Abdullahi, A, Abedi, A, Abedi, V, Abeldano Zuniga, R, Abidi, H, Abiodun, O, Aboagye, R, Abolhassani, H, Aboyans, V, Abrha, W, Abualhasan, A, Abu-Gharbieh, E, Aburuz, S, Adamu, L, Addo, I, Adebayo, O, Adekanmbi, V, Adekiya, T, Adikusuma, W, Adnani, Q, Adra, S, Afework, T, Afolabi, A, Afraz, A, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, S, Ahmadzade, A, Ahmed, A, Ahmed, H, Ahmed, J, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Ajumobi, O, Akade, S, Akbari, M, Akbarialiabad, H, Akhlaghi, S, Akinosoglou, K, Akinyemi, R, Akonde, M, Al Hasan, S, Alahdab, F, Al-Ahdal, T, Al-Amer, R, Albashtawy, M, Albataineh, M, Aldawsari, K, Alemi, H, Alemi, S, Algammal, A, Al-Gheethi, A, Alhalaiqa, F, Alhassan, R, Ali, A, Ali, E, Ali, L, Ali, M, Ali, R, Ali, S, Shujait Ali, S, Ali, Z, Alif, S, Alimohamadi, Y, Aliyi, A, Aljofan, M, Aljunid, S, Alladi, S, Almazan, J, Almustanyir, S, Al-Omari, B, Alqahtani, J, Alqasmi, I, Alqutaibi, A, Al-Shahi Salman, R, Altaany, Z, Al-Tawfiq, J, Altirkawi, K, Alvis-Guzman, N, Al-Worafi, Y, Aly, H, Aly, S, Alzoubi, K, Amani, R, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, M, Amu, H, Amugsi, D, Amusa, G, Amzat, J, Ancuceanu, R, Anderlini, D, Anderson, D, Andrei, C, Androudi, S, Angappan, D, Angesom, T, Anil, A, Ansari-Moghaddam, A, Anwer, R, Arafat, M, Aravkin, A, Areda, D, Ariffin, H, Arifin, H, Arkew, M, Arnlov, J, Arooj, M, Artamonov, A, Artanti, K, Aruleba, R, Asadi-Pooya, A, Asena, T, Asghari-Jafarabadi, M, Ashraf, M, Ashraf, T, Atalell, K, Athari, S, Atinafu, B, Atorkey, P, Atout, M, Atreya, A, Aujayeb, A, Avan, A, Ayala Quintanilla, B, Ayatollahi, H, Ayinde, O, Mohammad Ayyoubzadeh, S, Azadnajafabad, S, Azizi, Z, Azizian, K, Azzam, A, Babaei, M, Badar, M, Badiye, A, Baghdadi, S, Bagherieh, S, Bai, R, Baig, A, Balakrishnan, S, Balalla, S, Baltatu, O, Banach, M, Bandyopadhyay, S, Banerjee, I, Baran, M, Barboza, M, Barchitta, M, Bardhan, M, Barker-Collo, S, Barnighausen, T, Barrow, A, Bashash, D, Bashiri, H, Bashiru, H, Basiru, A, Basso, J, Basu, S, Batiha, A, Batra, K, Baune, B, Bedi, N, Begde, A, Begum, T, Behnam, B, Behnoush, A, Beiranvand, M, Bejot, Y, Bekele, A, Belete, M, Belgaumi, U, Bemanalizadeh, M, Bender, R, Benfor, B, Bennett, D, Bensenor, I, Berice, B, Bettencourt, P, Beyene, K, Bhadra, A, Bhagat, D, Bhangdia, K, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, A, Bhat, V, Bhatti, G, Bhatti, J, Bhatti, R, Bijani, A, Bikbov, B, Bilalaga, M, Biswas, A, Bitaraf, S, Bitra, V, Bjorge, T, Bodolica, V, Bodunrin, A, Boloor, A, Braithwaite, D, Brayne, C, Brenner, H, Briko, A, Bringas Vega, M, Brown, J, Budke, C, Buonsenso, D, Burkart, K, Burns, R, Bustanji, Y, Butt, M, Butt, N, Butt, Z, Cabral, L, dos Santos, F, Calina, D, Campos-Nonato, I, Cao, C, Carabin, H, Cardenas, R, Carreras, G, Carvalho, A, Castaneda-Orjuela, C, Casulli, A, Catala-Lopez, F, Catapano, A, Caye, A, Cegolon, L, Cenderadewi, M, Cerin, E, Chacon-Uscamaita, P, Chan, J, Chanie, G, Charan, J, Chattu, V, Chekol Abebe, E, Chen, H, Chen, J, Chi, G, Chichagi, F, Chidambaram, S, Chimoriya, R, Ching, P, Chitheer, A, Chong, Y, Chopra, H, Choudhari, S, Chowdhury, E, Chowdhury, R, Christensen, H, Chu, D, Chukwu, I, Chung, E, Coberly, K, Columbus, A, Comachio, J, Conde, J, Cortesi, P, Costa, V, Couto, R, Criqui, M, Cruz-Martins, N, Dabbagh Ohadi, M, Dadana, S, Dadras, O, Dai, X, Dai, Z, D'Amico, E, Danawi, H, Dandona, L, Dandona, R, Darwish, A, Das, S, Dascalu, A, Dash, N, Dashti, M, De la Hoz, F, de la Torre-Luque, A, De Leo, D, Dean, F, Dehghan, A, Dejene, H, Demant, D, Demetriades, A, Demissie, S, Deng, X, Desai, H, Devanbu, V, Dhama, K, Dharmaratne, S, Dhimal, M, Dias da Silva, D, Diaz, D, Dibas, M, Ding, D, Dinu, M, Dirac, M, Diress, M, Do, T, Doan, K, Dodangeh, M, Doheim, M, Dokova, K, Dongarwar, D, Dsouza, H, Dube, J, Duraisamy, S, Durojaiye, O, Dutta, S, Dziedzic, A, Edinur, H, Eissazade, N, Ekholuenetale, M, Ekundayo, T, El Nahas, N, El Sayed, I, Elahi Najafi, M, Elbarazi, I, Elemam, N, Elgar, F, Elgendy, I, Elhabashy, H, Elhadi, M, Elilo, L, Ellenbogen, R, Elmeligy, O, Elmonem, M, Elshaer, M, Elsohaby, I, Emamverdi, M, Emeto, T, Endres, M, Esezobor, C, Eskandarieh, S, Fadaei, A, Fagbamigbe, A, Fahim, A, Faramarzi, A, Fares, J, Farjoud Kouhanjani, M, Faro, A, Farzadfar, F, Fatehizadeh, A, Fathi, M, Fathi, S, Fatima, S, Feizkhah, A, Fereshtehnejad, S, Ferrari, A, Ferreira, N, Fetensa, G, Firouraghi, N, Fischer, F, Fonseca, A, Force, L, Fornari, A, Foroutan, B, Fukumoto, T, Gadanya, M, Gaidhane, A, Galali, Y, Galehdar, N, Gan, Q, Gandhi, A, Ganesan, B, Gardner, W, Garg, N, Gau, S, Gautam, R, Gebre, T, Gebrehiwot, M, Gebremeskel, G, Gebreslassie, H, Getacher, L, Ghaderi Yazdi, B, Ghadirian, F, 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H., Cruz-Martins N., Dabbagh Ohadi M. A., Dadana S., Dadras O., Dai X., Dai Z., D'Amico E., Danawi H. A., Dandona L., Dandona R., Darwish A. H., Das S., Dascalu A. M., Dash N. R., Dashti M., De la Hoz F. P., de la Torre-Luque A., De Leo D., Dean F. E., Dehghan A., Dejene H., Demant D., Demetriades A. K., Demissie S., Deng X., Desai H. D., Devanbu V. G. C., Dhama K., Dharmaratne S. D., Dhimal M., Dias da Silva D., Diaz D., Dibas M., Ding D. D., Dinu M., Dirac M. A., Diress M., Do T. C., Do T. H. P., Doan K. D. K., Dodangeh M., Doheim M. F., Dokova K. G., Dongarwar D., Dsouza H. L., Dube J., Duraisamy S., Durojaiye O. C., Dutta S., Dziedzic A. M., Edinur H. A., Eissazade N., Ekholuenetale M., Ekundayo T. C., El Nahas N., El Sayed I. E., Elahi Najafi M. A. E., Elbarazi I., Elemam N. M., Elgar F. J., Elgendy I. Y., Elhabashy H. R., Elhadi M., Elilo L. T., Ellenbogen R. G., Elmeligy O. A. A., Elmonem M. A., Elshaer M., Elsohaby I., Emamverdi M., Emeto T. I., Endres M., Esezobor C. I., Eskandarieh S., Fadaei A., Fagbamigbe A. F., Fahim A., Faramarzi A., Fares J., Farjoud Kouhanjani M., Faro A., Farzadfar F., Fatehizadeh A., Fathi M., Fathi S., Fatima S. A. F., Feizkhah A., Fereshtehnejad S. -M., Ferrari A. J., Ferreira N., Fetensa G., Firouraghi N., Fischer F., Fonseca A. C., Force L. M., Fornari A., Foroutan B., Fukumoto T., Gadanya M. A., Gaidhane A. M., Galali Y., Galehdar N., Gan Q., Gandhi A. P., Ganesan B., Gardner W. M., Garg N., Gau S. -Y., Gautam R. K., Gebre T., Gebrehiwot M., Gebremeskel G. G., Gebreslassie H. G., Getacher L., Ghaderi Yazdi B., Ghadirian F., Ghaffarpasand F., Ghanbari R., Ghasemi M., Ghazy R. M., Ghimire S., Gholami A., Gholamrezanezhad A., Ghotbi E., Ghozy S., Gialluisi A., Gill P. S., Glasstetter L. M., Gnedovskaya E. V., Golchin A., Golechha M., Goleij P., Golinelli D., Gomes-Neto M., Goulart A. C., Goyal A., Gray R. J., Grivna M., Guadie H. A., Guan B., Guarducci G., Guicciardi S., Gunawardane D. A., Guo H., Gupta B., Gupta R., Gupta S., Gupta V. B., Gupta V. K., Gutierrez R. A., Habibzadeh F., Hachinski V., Haddadi R., Hadei M., Hadi N. R., Haep N., Haile T. G., Haj-Mirzaian A., Hall B. J., Halwani R., Hameed S., Hamiduzzaman M., Hammoud A., Han H., Hanifi N., Hankey G. J., Hannan M. A., Hao J., Harapan H., Hareru H. E., Hargono A., Harlianto N. I., Haro J. M., Hartman N. N., Hasaballah A. I., Hasan F., Hasani H., Hasanian M., Hassan A., Hassan S., Hassanipour S., Hassankhani H., Hassen M. B., Haubold J., Hay S. I., Hayat K., Hegazy M. I., Heidari G., Heidari M., Heidari-Soureshjani R., Hesami H., Hezam K., Hiraike Y., Hoffman H. J., Holla R., Hopf K. P., Horita N., Hossain M. M., Hossain M. B., Hossain S., Hosseinzadeh H., Hosseinzadeh M., Hostiuc S., Hu C., Huang J., Huda M. N., Hussain J., Hussein N. R., Huynh H. -H., Hwang B. -F., Ibitoye S. E., Ilaghi M., Ilesanmi O. S., Ilic I. M., Ilic M. D., Immurana M., Iravanpour F., Islam S. M. 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K., Khanmohammadi S., Khanna T., Khatab K., Khatatbeh H., Khatatbeh M. M., Khateri S., Khatib M. N., Khayat Kashani H. R., Khonji M. S., Khorashadizadeh F., Khormali M., Khubchandani J., Kian S., Kim G., Kim J., Kim M. S., Kim Y. J., Kimokoti R. W., Kisa A., Kisa S., Kivimaki M., Kochhar S., Kolahi A. -A., Koly K. N., Kompani F., Koroshetz W. J., Kosen S., Kourosh Arami M., Koyanagi A., Kravchenko M. A., Krishan K., Krishnamoorthy V., Defo B. K., Kuddus M. A., Kumar A., Kumar G. A., Kumar M., Kumar N., Kumsa N. B., Kundu S., Kurniasari M. D., Kusuma D., Kuttikkattu A., Kyu H. H., La Vecchia C., Ladan M. A., Lahariya C., Laksono T., Lal D. K., Lallukka T., Lam J., Lami F. H., Landires I., Langguth B., Lasrado S., Latief K., Latifinaibin K., Lau K. M. -M., Laurens M. B., Lawal B. K., Le L. K. D., Le T. T. T., Ledda C., Lee M., Lee S. -W., Lee S. W., Lee W. -C., Lee Y. H., Leonardi M., Lerango T. L., Li M. -C., Li W., Ligade V. S., Lim S. S., Linehan C., Liu C., Liu J., Liu W., Lo C. -H., Lo W. D., Lobo S. W., Logroscino G., Lopes G., Lopukhov P. D., Lorenzovici L., Lorkowski S., Loureiro J. A., Lubinda J., Lucchetti G., Saute R. L., Ma Z. F., Mabrok M., Machoy M., Madadizadeh F., El Razek M. M. A., Maghazachi A. A., Maghbouli N., Mahjoub S., Mahmoudi M., Majeed A., Malagon-Rojas J. N., Malakan Rad E., Malhotra K., Malik A. A., Malik I., Mallhi T. H., Malta D. C., Manilal A., Mansouri V., Mansournia M. A., Marasini B. P., Marateb H. R., Maroufi S. F., Martinez-Raga J., Martini S., Martins-Melo F. R., Martorell M., Marz W., Marzo R. R., Massano J., Mathangasinghe Y., Mathews E., Maude R. J., Maugeri A., Maulik P. K., Mayeli M., Mazaheri M., McAlinden C., McGrath J. J., Meena J. K., Mehndiratta M. M., Mendez-Lopez M. A. M., Mendoza W., Mendoza-Cano O., Menezes R. G., Merati M., Meretoja A., Merkin A., Mersha A. M., Mestrovic T., Mi T., Miazgowski T., Michalek I. M., Mihretie E. T., Minh L. H. N., Mirfakhraie R., Mirica A., Mirrakhimov E. M., Mirzaei M., Misganaw A., Misra S., Mithra P., Mizana B. A., Mohamadkhani A., Mohamed N. S., Mohammadi E., Mohammadi H., Mohammadi S., Mohammadshahi M., Mohammed M., Mohammed S., Mohan S., Mojiri-Forushani H., Moka N., Mokdad A. H., Molinaro S., Moller H., Monasta L., Moniruzzaman M., Montazeri F., Moradi M., Moradi Y., Moradi-Lakeh M., Moraga P., Morovatdar N., Morrison S. D., Mosapour A., Mosser J. F., Mossialos E., Motaghinejad M., Mousavi P., Ehsan Mousavi S., Mubarik S., Muccioli L., Mughal F., Mukoro G. D., Mulita A., Mulita F., Musaigwa F., Mustafa A., Mustafa G., Muthu S., Nagarajan A. J., Naghavi P., Naik G. R., Nainu F., Nair T. S., Najmuldeen H. H. R., Nakhostin Ansari N., Nambi G., Namdar Areshtanab H., Nargus S., Nascimento B. R., Naser A. Y., Nashwan A. J. J., Nasoori H., Nasreldein A., Natto Z. S., Nauman J., Nayak B. P., Nazri-Panjaki A., Negaresh M., Negash H., Negoi I., Negoi R. I., Negru S. M., Nejadghaderi S. A., Nematollahi M. H., Nesbit O. D., Newton C. R. J., Nguyen D. H., Nguyen H. T. H., Nguyen H. Q., Nguyen N. -T. T., Nguyen P. T., Nguyen V. T., Niazi R. K., Nikolouzakis T. K., Niranjan V., Nnyanzi L. A., Noman E. A., Noroozi N., Norrving B., Noubiap J. J., Nri-Ezedi C. A., Ntaios G., Nunez-Samudio V., Nurrika D., Oancea B., Odetokun I. A., O'Donnell M. J., Ogunsakin R. E., Oguta J. O., Oh I. -H., Okati-Aliabad H., Okeke S. R., Okekunle A. P., Okonji O. C., Okwute P. G., Olagunju A. T., Olaiya M. T., Olana M. D., Olatubi M. I., Oliveira G. M. M., Olufadewa I. I., Olusanya B. O., Bali A. O., Ong S., Onwujekwe O. E., Ordak M., Orji A. U., Ortega-Altamirano D. V., Osuagwu U. L., Otstavnov N., Otstavnov S. S., Ouyahia A., Owolabi M. O., Mahesh Padukudru P. A., Pacheco-Barrios K., Padubidri J. R., Pal P. K., Palange P. N., Palladino C., Palladino R., Palma-Alvarez R. F., Pan F., Panagiotakos D., Panda-Jonas S., Pandey A., Pandian J. D., Pangaribuan H. U., Pantazopoulos I., Pardhan S., Parija P. P., Parikh R. R., Park S., Parthasarathi A., Pashaei A., Patel J., Patil S., Patoulias D., Pawar S., Pedersini P., Pensato U., Pereira D. M., Pereira J., Pereira M. O., Peres M. F. P., Perico N., Perna S., Petcu I. -R., Petermann-Rocha F. E., Pham H. T., Phillips M. R., Pinilla-Monsalve G. D., Piradov M. A., Plotnikov E., Poddighe D., Polat B., Poluru R., Pond C. D., Poudel G. R., Pouramini A., Pourbagher-Shahri A. M., Pourfridoni M., Pourtaheri N., Prakash P. Y., Prakash S., Prakash V., Prates E. J. S., Pritchett N., Purnobasuki H., Qasim N. H., Qattea I., Qian G., Radhakrishnan V., Raee P., Shahraki H. R., Rafique I., Raggi A., Raghav P. R., Rahati M. M., Rahim F., Rahimi Z., Rahimifard M., Rahman M. O., Rahman M. H. U., Rahman M., Rahman M. A., Rahmani A. M., Rahmani S., Youshanlouei H. R., Rahmati M., Raj Moolambally S., Rajabpour-Sanati A., Ramadan H., Ramasamy S. K., Ramasubramani P., Ramazanu S., Rancic N., Rao I. R., Rao S. J., Rapaka D., Rashedi V., Rashid A. M., Rashidi M. -M., Rashidi Alavijeh M., Rasouli-Saravani A., Rawaf S., Razo C., Redwan E. M. M., Bana A. R., Remuzzi G., Rezaei N., Rezaeian M., Rhee T. G., Riad A., Robinson S. R., Rodrigues M., Rodriguez J. A. B., Roever L., Rogowski E. L. B., Romoli M., Ronfani L., Roy P., Pramanik K. R., Rubagotti E., Ruiz M. A., Russ T. C., Sunnerhagen K. S., Saad A. M. A., Saadatian Z., Saber K., SaberiKamarposhti M., Sacco S., Saddik B., Sadeghi E., Sadeghian S., Saeed U., Safdarian M., Safi S. Z., Sagar R., Sagoe D., Saheb Sharif-Askari F. S., Saheb Sharif-Askari N., Sahebkar A., Sahoo S. S., Sahraian M. A., Sajedi S. A., Sakshaug J. W., Saleh M. A., Salehi Omran H., Salem M. R., Salimi S., Samadi Kafil H., Samadzadeh S., Samargandy S., Samodra Y. L., Samuel V. P., Samy A. M., Sanadgol N., Sanjeev R. K., Sanmarchi F., Santomauro D. F., Santri I. N., Santric-Milicevic M. M., Saravanan A., Sarveazad A., Satpathy M., Saylan M., Sayyah M., Scarmeas N., Schlaich M. P., Schuermans A., Schwarzinger M., Schwebel D. C., Selvaraj S., Sendekie A. K., Sengupta P., Senthilkumaran S., Serban D., Sergindo M. T., Sethi Y., SeyedAlinaghi S., Seylani A., Shabani M., Shabany M., Shafie M., Shahabi S., Shahbandi A., Shahid S., Shahraki-Sanavi F., Shahsavari H. R., Shahwan M. J., Shaikh M. A., Shaji K. S., Sham S., Shama A. T. T., Shamim M. A., Shams-Beyranvand M., Shamsi M. A., Shanawaz M., Sharath M., Sharfaei S., Sharifan A., Sharma M., Sharma R., Shashamo B. B., Shayan M., Sheikhi R. A., Shekhar S., Shen J., Shenoy S. M., Shetty P. H., Shiferaw D. S., Shigematsu M., Shiri R., Shittu A., Shivakumar K. M., Shokri F., Shool S., Shorofi S. A., Shrestha S., Siankam Tankwanchi A. B., Siddig E. E., Sigfusdottir I. D., Silva J. P., Silva L. M. L. R., Sinaei E., Singh B. B., Singh G., Singh P., Singh S., Sirota S. B., Sivakumar S., Sohag A. A. M., Solanki R., Soleimani H., Solikhah S., Solomon Y., Song S., Song Y., Sotoudeh H., Spartalis M., Stark B. A., Starnes J. R., Starodubova A. V., Stein D. J., Steiner T. J., Stovner L. J., Suleman M., Abdulkader R. S., Sultana A., Sun J., Sunkersing D., Sunny A., Susianti H., Swain C. K., Szeto M. D., Tabares-Seisdedos R., Tabatabaei S. M., Tabatabai S., Tabish M., Taheri M., Tahvildari A., Tajbakhsh A., Tampa M., Lukenze Tamuzi J. J. L., Tan K. -K., Tang H., Tareke M., Tarigan I. U., Tat N. Y., Tat V. Y., Tavakoli Oliaee R., Tavangar S. M., Tavasol A., Tefera Y. M., Tehrani-Banihashemi A., Temesgen W. A., Temsah M. -H., Teramoto M., Tesfaye A. H., Tesfaye E. G., Tesler R., Thakali O., Thangaraju P., Thapa R., Thapar R., Thomas N. K., Thrift A. G., Ticoalu J. H. V., Tillawi T., Toghroli R., Tonelli M., Tovani-Palone M. R., Traini E., Tran N. M., Tran N. -H., Van Tran P., Tromans S. J., Truelsen T. C., Truyen T. T. T. T., Tsatsakis A., Tsegay G. M., Tsermpini E. E., Tualeka A. R., Tufa D. G., Ubah C. S., Udoakang A. J., Ulhaq I., Umair M., Umakanthan S., Umapathi K. K., Unim B., Unnikrishnan B., Vaithinathan A. G., Vakilian A., Tahbaz S. V., Valizadeh R., Van den Eynde J., Vart P., Varthya S. B., Vasankari T. J., Vaziri S., Vellingiri B., Venketasubramanian N., Verras G. -I., Vervoort D., Villafane J. H., Villani L., Veloz A. F. V., Viskadourou M., Vladimirov S. K., Vlassov V., Volovat S. R., Vu L. T., Vujcic I. S., Wagaye B., Waheed Y., Wahood W., Walde M. T., Wang F., Wang S., Wang Y., Wang Y. -P., Waqas M., Waris A., Weerakoon K. G., Weintraub R. G., Weldemariam A. H., Westerman R., Whisnant J. L., Wickramasinghe D. P., Wickramasinghe N. D., Willekens B., Wilner L. B., Winkler A. S., Wolfe C. D. A., Wu A. -M., Wulf Hanson S., Xu S., Xu X., Yadollahpour A., Yaghoubi S., Yahya G., Yamagishi K., Yang L., Yano Y., Yao Y., Yehualashet S. S., Yeshaneh A., Yesiltepe M., Yi S., Yigit A., Yigit V., Yon D. K., Yonemoto N., You Y., Younis M. Z., Yu C., Yusuf H., Zadey S., Zahedi M., Zakham F., Zaki N., Zali A., Zamagni G., Zand R., Zandieh G. G. Z., Zangiabadian M., Zarghami A., Zastrozhin M. S., Zeariya M. G. M., Zegeye Z. B., Zeukeng F., Zhai C., Zhang C., Zhang H., Zhang Y., Zhang Z. -J., Zhao H., Zhao Y., Zheng P., Zhou H., Zhu B., Zhumagaliuly A., Zielinska M., Zikarg Y. T., Zoladl M., Murray C. J. L., Ong K. L., Feigin V. L., Vos T., and Dua T.

Abstract

Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous s

Published
2024

28. Combined limit on the production of a light gauge boson decaying into $\mu^+\mu^-$ and $\pi^+\pi^-$

Author

Collaboration, KLOE-2, Anastasi, A., Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostinio, G., Dané, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E. A., Krzemien, W., Kupsc, A., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Passeri, A., Patera, V., del Rio, E. Perez, Raha, N., Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment
Abstract

We searched for the $\mu^+\mu^-$ decay of a light vector gauge boson, also known as dark photon, in the $e^+ e^- \to \mu^+ \mu^- \gamma_{\rm ISR}$ process by means of the Initial State Radiation (ISR) method. We used 1.93~fb$^{-1}$ of data collected by the KLOE experiment at the DA$\Phi$NE $\phi$-factory. No structures have been observed over the irreducible $\mu^+ \mu^-$ background. A 90\% CL limit on the ratio $\varepsilon^2=\alpha^{\prime}/\alpha$ between the dark coupling constant and the fine structure constant of $ 3\times 10^{-6}-2\times 10^{-7}$ has been set in the dark photon mass region between 519 MeV and 973 MeV. This new limit has been combined with the published result obtained investigating the hypothesis of the dark photon decaying into hadrons in $e^+ e^- \to \pi^+ \pi^- \gamma_{\rm ISR}$ events. The combined 90\% CL limit increases the sensitivity especially in the $\rho-\omega$ interference region and excludes $\varepsilon^2$ greater than $(13-2)\times 10^{-7}$. For dark photon masses greater than 600 MeV the combined limit is lower than 8~$\times\, 10^{-7}$ resulting more stringent than present constraints from other experiments., Comment: 7 pages, 9 figures, 1 table, accepted for publication in Physics Letters B

Published
2018
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29. Measurement of the charge asymmetry for the $K_S \rightarrow \pi e \nu$ decay and test of CPT symmetry with the KLOE detector

Author

Anastasi, A., Babusci, D., Berłowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Capon, G., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E. A., Krzemień, W., Kupść, A., Loffredo, S., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Passeri, A., Patera, V., del Rio, E. Perez, Raha, N., Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment
Abstract

Using 1.63 fb$^{-1}$ of integrated luminosity collected by the KLOE experiment about $7\times 10^4$ $K_S \rightarrow \pi^{\pm}e^{\mp}\nu$ decays have been reconstructed. The measured value of the charge asymmetry for this decay is $A_S = (-4.9 \pm 5.7_{stat} \pm 2.6_{syst}) \times 10^{-3}$, which is almost twice more precise than the previous KLOE result. The combination of these two measurements gives $A_S = (-3.8 \pm 5.0_{stat} \pm 2.6_{syst}) \times 10^{-3}$ and, together with the asymmetry of the $K_L$ semileptonic decay, provides significant tests of the CPT symmetry. The obtained results are in agreement with CPT invariance., Comment: submitted to JHEP

Published
2018
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32. Measurement of the KS→ πeν branching fraction with the KLOE experiment

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D’Agostini, G., D’Amico, R., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Diociaiuti, E., Domenici, D., D’Uffizi, A., Fantini, G., Gajos, A., Gamrat, S., Gauzzi, P., Giovannella, S., Graziani, E., Kang, X., Kupsc, A., Mandaglio, G., Martini, M., Miscetti, S., Moskal, P., Passeri, A., Perez del Rio, E., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Wiślicki, W., and Wolke, M.

Published
2023
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34. Prognostic Factors for Cardiovascular Events in Elderly Patients with Community Acquired Pneumonia: Results from the CAP-China Network

Author

Han X, Chen L, Li H, Zhou F, Xing X, Zhang C, Suo L, Wang J, Liu X, and Cao B

Subjects
community-acquired pneumonia, cardiovascular events, prognostic factors, elderly, Geriatrics, RC952-954.6
Abstract

Xiudi Han,1 Liang Chen,2 Hui Li,3 Fei Zhou,3 Xiqian Xing,4 Chunxiao Zhang,5 Lijun Suo,6 Jinxiang Wang,7 Xuedong Liu,1 Bin Cao3 On behalf of the CAP-China network1Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital Group, Qingdao City, Shandong Province, 266011, People’s Republic of China; 2Department of Infectious Diseases, Nanjing Lishui People’s Hospital, Nanjing City, Jiangsu Province, 211213, People’s Republic of China; 3National Clinical Research Center of Respiratory Diseases, Center for Respiratory Diseases, China-Japan Friendship Hospital; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, 100020, People’s Republic of China; 4Department of Respiratory Medicine, Yan’an Hospital Affiliated to Kunming Medical University, Kunming City, Yunnan Province, 652199, People’s Republic of China; 5Department of Respiratory Medicine, Beijing Huimin Hospital, Beijing, 100054, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Zibo Municipal Hospital, Zibo City, Shandong Province, 255000, People’s Republic of China; 7Department of Respiratory Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People’s Republic of ChinaCorrespondence: Xuedong Liu, Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital Group, Jiaozhou Road, Qingdao City, Shandong Province, 266011, People’s Republic of China, Tel +86-18661678256, Fax +86-532-82789055, Email xuedongliu@263.net Bin Cao, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Yinghuayuan East Street, Chao-Yang District, Beijing, 100020, People’s Republic of China, Tel +86-13911318339, Fax +86-10-84206264, Email caobin_ben@163.comBackground: Limited data were available about the burden of cardiovascular events (CVEs) during hospitalization in elderly patients with community-acquired pneumonia (CAP). The aim was to assess the incidence, characteristics, predictive factors and outcomes of CVEs in elderly patients with CAP during hospitalization.Methods: This study was a multicenter, retrospective research on hospitalized elderly patients with CAP from the CAP-China network. Predictive factors for the occurrence of CVEs and 30-day mortality were identified by multivariable logistic regression analysis.Results: Of 2941 hospitalized elderly patients, 402 (13.7%) developed CVEs during hospitalization with the median age of 81 years old. Compared with non-CVEs patients, patients with CVEs were older, more comorbidities, and higher disease severity; use of glucocorticoids, leukocytosis, azotemia, hyponatremia, multilobe infiltration and pleural effusion were more common; the rate of clinical failure (CF), in-hospital mortality and 30-day mortality were higher, which significantly increased with age and the number of CVEs (p < 0.001). Multivariable logistic regression showed previous history of congestive heart failure (odds ratio [OR], 6.16; 95% CI, 4.14– 9.18), CF (OR, 4.69; 95% CI, 3.392– 6.48), previous history of ischemic heart disease (OR, 2.22; 95% CI, 1.61– 3.07), use of glucocorticoids (OR, 2.0; 95% CI, 1.39– 2.89), aspiration (OR, 1.88; 95% CI, 1.26– 2.81), pleural effusion (OR, 1.66; 95% CI, 1.25– 2.20), multilobe infiltration (OR, 1.50; 95% CI, 1.15– 1.96), age (OR, 1.05; 95% CI, 1.04– 1.07), and blood urea nitrogen (OR, 1.03; 95% CI, 1.01– 1.06) were independent predictors for the occurrence of CVEs, while level of blood sodium (OR, 0.98; 95% CI, 0.97– 0.99) was protective factor. Renal failure (OR, 9.46; 95% CI, 4.17– 21.48), respiratory failure (OR, 9.32; 95% CI, 5.91– 14.71), sepsis/septic shock (OR, 7.87; 95% CI, 3.58– 17.31), new cerebrovascular diseases (OR, 5.94; 95% CI, 1.78– 19.87), new heart failure (OR, 4.04; 95% CI, 1.15– 14.14), new arrhythmia (OR, 2.38; 95% CI, 1.11– 5.14), aspiration (OR, 1.95; 95% CI, 1.09– 3.50), CURB-65 (OR, 1.57; 95% CI, 1.21– 2.02), and white blood cell count (OR, 1.05; 95% CI, 1.02– 1.09) were independent predictors for 30-day mortality in elderly patients with CAP, while lymphocyte count (OR, 0.63; 95% CI, 0.46– 0.87) was protective factor.Conclusion: Patients with CVEs had heavier disease burden and worse prognosis. Early recognition of risk factors is meaningful to strengthen the management in elderly patients with CAP.Keywords: community-acquired pneumonia, cardiovascular events, prognostic factors, elderly

Published
2022

35. Combination of KLOE $\sigma\big(e^+e^-\rightarrow\pi^+\pi^-\gamma(\gamma)\big)$ measurements and determination of $a_{\mu}^{\pi^+\pi^-}$ in the energy range $0.10 < s < 0.95$ GeV$^2$

Author

Collaboration, The KLOE-2, Anastasi, A., Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Balkeståhl, L. Caldeira, Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kisielewska-Kamińska, D., Kang, X., Kozyrev, E. A., Krzemien, W., Kupsc, A., Loffredo, S., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Passeri, A., Patera, V., del Rio, E. Perez, Raha, N., Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., Wolke, M., Keshavarzi, A., Müller, S. E., and Teubner, T.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The three precision measurements of the cross section $\sigma\big(e^+e^-\rightarrow\pi^+\pi^-\gamma(\gamma)\big)$ using initial state radiation by the KLOE collaboration provide an important input for the prediction of the hadronic contribution to the anomalous magnetic moment of the muon. These measurements are correlated for both statistical and systematic uncertainties and, therefore, the simultaneous use of these measurements requires covariance matrices that fully describe the correlations. We present the construction of these covariance matrices and use them to determine a combined KLOE measurement for $\sigma\big(e^+e^-\rightarrow\pi^+\pi^-\gamma(\gamma)\big)$. We find, from this combination, a two-pion contribution to the muon magnetic anomaly in the energy range $0.10 < s < 0.95$ GeV$^2$ of $a_{\mu}^{\pi^+\pi^-} = (489.8 \pm 1.7_{\rm stat} \pm 4.8_{\rm sys} ) \times 10^{-10}$., Comment: 20 pages, 8 figures. Version as published in JHEP 1803 (2018) 173

Published
2017

36. Investigating calcite growth rates using a quartz crystal microbalance with dissipation (QCM-D)

Author

Cao, B, Stack, AG, Steefel, CI, DePaolo, DJ, Lammers, LN, and Hu, Y

Subjects
Crystal growth rate, Calcite, Quartz crystal microbalance with dissipation, Step density, Step velocity, Geochemistry & Geophysics, Geochemistry, Geology, Physical Geography and Environmental Geoscience
Abstract

Calcite precipitation plays a significant role in processes such as geological carbon sequestration and toxic metal sequestration and, yet, the rates and mechanisms of calcite growth under close to equilibrium conditions are far from well understood. In this study, a quartz crystal microbalance with dissipation (QCM-D) was used for the first time to measure macroscopic calcite growth rates. Calcite seed crystals were first nucleated and grown on sensors, then growth rates of calcite seed crystals were measured in real-time under close to equilibrium conditions (saturation index, SI = log ({Ca2+}/{CO32−}/Ksp) = 0.01–0.7, where {i} represent ion activities and Ksp = 10−8.48 is the calcite thermodynamic solubility constant). At the end of the experiments, total masses of calcite crystals on sensors measured by QCM-D and inductively coupled plasma mass spectrometry (ICP-MS) were consistent, validating the QCM-D measurements. Calcite growth rates measured by QCM-D were compared with reported macroscopic growth rates measured with auto-titration, ICP-MS, and microbalance. Calcite growth rates measured by QCM-D were also compared with microscopic growth rates measured by atomic force microscopy (AFM) and with rates predicted by two process-based crystal growth models. The discrepancies in growth rates among AFM measurements and model predictions appear to mainly arise from differences in step densities, and the step velocities were consistent among the AFM measurements as well as with both model predictions. Using the predicted steady-state step velocity and the measured step densities, both models predict well the growth rates measured using QCM-D and AFM. This study provides valuable insights into the effects of reactive site densities on calcite growth rate, which may help design future growth models to predict transient-state step densities.

Published
2018

40. Prognostic Value of Preoperative Mean Platelet Volume and a Predictive Nomogram in Oral Squamous Cell Carcinoma Patients Based on Real-World Data

Author

Ning Y, Yang H, Qin S, Cao B, Zhong Z, He C, and Zhu G

Subjects
oral squamous cell carcinoma, overall survival, nomogram, mean platelet volume, neoadjuvant chemotherapy, induction chemotherapy., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Yudong Ning,1 Hong Yang,2 Sheng Qin,2 Bangrong Cao,3 Zuxian Zhong,4 Chuanshi He,5 Guiquan Zhu6 1Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 2Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 3Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 4Department of Head and Neck Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 5Sichuan Key Laboratory of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, People’s Republic of China; 6Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Guiquan ZhuDepartment of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail zhugq@scu.edu.cnObjective: We aimed to identify new prognostic factors of oral squamous cell carcinoma (OSCC) among platelet-related parameters, establish a survival prediction model to predict the survival status of OSCC patients, and analyze the therapeutic effect of neoadjuvant chemotherapy on OSCC patients on the basis of real-world data.Materials and Methods: The real-world data of patients with OSCC confirmed by pathologic examination at Cancer Hospital from January 2011 to January 2015 and May 2017 to January 2020 were collected. We analyzed clinicopathologic factors using a Cox regression analysis, the Kaplan-Meier method, and propensity score matching (PSM).Results: The multivariate Cox regression analysis of not only validated the traditional prognostic factors such as tumor site, neural invasion, poor differentiation, and tumor-node-metastasis (TNM) stage but also identified a new prognostic factor, preoperative mean platelet volume (MPV) for overall survival (OS, HR, 0.47; 95% CI: 0.25– 0.89, P = 0.020). A nomogram was created to predict the probability of 3-year and 5-year OS. We found that neoadjuvant chemotherapy improved OS in patients with OSCC.Conclusion: Preoperative MPV, being associated with female, neoadjuvant chemotherapy, and advanced stage (Stage III and IV), may be a new prognostic factor for OS of patients with OSCC. The nomograms provided useful prediction for OS in OSCC patients. Neoadjuvant chemotherapy may improve the OS of patients with OSCC.Keywords: oral squamous cell carcinoma, overall survival, nomogram, mean platelet volume, neoadjuvant chemotherapy, induction chemotherapy

Published
2021

41. Measurement of the running of the fine structure constant below 1 GeV with the KLOE Detector

Author

Collaboration, The KLOE-2, Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Balkeståhl, L. Caldeira, Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Dané, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Lukin, P. A., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Papenbrock, M., Passeri, A., Patera, V., del Rio, E. Perez, Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., Wolke, M., and Jegerlehner, F.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We have measured the running of the effective QED coupling constant $\alpha(s)$ in the time-like region $0.6<\sqrt s< 0.975$ GeV with the KLOE detector at DA$\Phi$NE using the Initial State Radiation process $e^+e^-\to\mu^+ \mu^-\gamma$. It represents the first measurement of the running of $\alpha(s)$ in this energy region. Our results show a more than 5$\sigma$ significance of the hadronic contribution to the running of $\alpha(s)$, which is the strongest direct evidence both in time- and space-like regions achieved in a single measurement. By using the $e^+e^-\to\pi^+\pi^-$ cross section measured by KLOE, the real and imaginary part of the shift $\Delta\alpha(s)$ has been extracted. By a fit of the real part of $\Delta\alpha(s)$ and assuming the lepton universality the branching ratio $BR(\omega\to\mu^+\mu^-) = (6.6\pm1.4_{stat}\pm1.7_{syst})\cdot 10^{-5} $ has been determined., Comment: 19 pages, 8 figures, version accepted for publication in Phys. Lett. B

Published
2016
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42. Limit on the production of a new vector boson in $\mathrm{e^+ e^-}\rightarrow {\rm U}\gamma$, U$\rightarrow \pi^+\pi^-$ with the KLOE experiment

Author

Collaboration, KLOE-2, Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Balkeståhl, L. Caldeira, Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwinski, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Andersson, W. Ikegami, Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Palladino, A., Papenbrock, M., Passeri, A., Patera, V., del Rio, E. Perez, Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment
Abstract

The recent interest in a light gauge boson in the framework of an extra U(1) symmetry motivates searches in the mass range below 1 GeV. We present a search for such a particle, the dark photon, in ${\rm e^+ e^-}\rightarrow {\rm U}\gamma$, U$\rightarrow \pi^+\pi^-$ based on 28 million $\mathrm{e^+ e^-} \rightarrow \pi^+ \pi^-\gamma$ events collected at DA$\Phi$NE by the KLOE experiment. The $\pi^+ \pi^-$ production by initial-state radiation compensates for a loss of sensitivity of previous KLOE ${\rm U} \rightarrow \mathrm{e^+ e^-}$, $\mu^+\mu^-$ searches due to the small branching ratios in the $\rho-\omega$ resonance region. We found no evidence for a signal and set a limit at 90\% CL on the mixing strength between the photon and the dark photon, $\varepsilon^2$, in the U mass range between $527$ and $987$~MeV. Above 700 MeV this new limit is more stringent than previous ones., Comment: 6 pages, 9 figures, 1 table, submitted to Phys. Lett. B

Published
2016
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43. Precision measurement of the $\eta\to\pi^+\pi^-\pi^0$ Dalitz plot distribution with the KLOE detector

Author

Collaboration, KLOE-2, Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Balkeståhl, L. Caldeira, Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Dané, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Andersson, W. Ikegami, Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Papenbrock, M., Passeri, A., Patera, V., del Rio, E. Perez, Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

Using $1.6$ fb$^{-1}$ of $e^+ e^-\to\phi\to\eta\gamma$ data collected with the KLOE detector at DA$\Phi$NE, the Dalitz plot distribution for the $\eta \to \pi^+ \pi^- \pi^0$ decay is studied with the world's largest sample of $\sim 4.7 \cdot 10^6$ events. The Dalitz plot density is parametrized as a polynomial expansion up to cubic terms in the normalized dimensionless variables $X$ and $Y$. The experiment is sensitive to all charge conjugation conserving terms of the expansion, including a $gX^2Y$ term. The statistical uncertainty of all parameters is improved by a factor two with respect to earlier measurements., Comment: 11 pages, 9 figures, supplement: an ascii table

Published
2016

44. Measurement of the $\phi \to \pi^0 e^+e^-$ transition form factor with the KLOE detector

Author

Collaboration, KLOE-2, Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Balkeståhl, L. Caldeira, Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Andersson, W. Ikegami, Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Papenbrock, M., Passeri, A., Patera, V., del Rio, E. Perez, Ranieri, A., Santangelo, P. Salabura P., Sarra, I., Schioppa, M., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

A measurement of the vector to pseudoscalar conversion decay $\phi \to \pi^0 e^+e^-$ with the KLOE experiment is presented. A sample of $\sim 9500$ signal events was selected from a data set of 1.7 fb$^{-1}$ of $e^+e^-$ collisions at $\sqrt{s} \sim m_{\phi}$ collected at the DA$\Phi$NE $e^+e^-$ collider. These events were used to obtain the first measurement of the transition form factor $| F_{\phi \pi^0}(q^2) |$ and a new measurement of the branching ratio of the decay: $\rm{BR}\,(\phi \to \pi^0 e^+e^-) = (\,1.35 \pm 0.05^{\,\,+0.05}_{\,\,-0.10}\,) \times 10 ^{-5}$. The result improves significantly on previous measurements and is in agreement with theoretical predictions., Comment: 13 pages, 4 figures; matches published version

Published
2016
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45. High Prevalence of Obesity but Low Physical Activity in Children Aged 9–11 Years in Beijing

Author

Liu M, Cao B, Liang X, Wu D, Li W, Su C, Chen J, and Gong C

Subjects
overweight, obesity, prevalence, risk factors, exercise time, Specialties of internal medicine, RC581-951
Abstract

Meijuan Liu, Bingyan Cao, Min Liu, Xuejun Liang, Di Wu, Wenjing Li, Chang Su, Jiajia Chen, Chunxiu Gong Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of ChinaCorrespondence: Chunxiu GongDepartment of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, People’s Republic of ChinaTel +86-10-59616161Email chunxiugong@sina.comObjective: To investigate the prevalence and associated factors of childhood overweight/obesity in the Shunyi district of Beijing, China.Methods: This study adopted a cross-sectional survey and included 10,855 children aged 6– 18 years in the Shunyi district of Beijing, China. Analyses were stratified by age group (6– 8, 9– 11, 12– 14, and 15– 18 years).Results: The prevalence of overweight and obesity among children aged 6– 18 years was high with 17.62% and 29.05% in boys, 17.57% and 18.04% in girls, respectively. Both boys and girls aged 9– 11 years had the highest rate of obesity in comparison with the other age groups, though the differences in children aged 9– 11 years and 12– 14 years were not statistically significant. Compared with age 6– 8 years, age 9– 11 years (OR=1.59, 95% CI 1.41– 1.79, P< 0.01) and 12– 14 years (OR=1.26, 95% CI 1.48– 1.73, P< 0.01) were independently positively associated with obesity. Importantly, in all subjects, the percentages of being physically active (exercise time ≥ 120 minutes/week) were lower in children aged 9– 11 years in comparison to children in other age groups. This phenomenon remained when this comparison was performed respectively in the normal-weight, overweight, and obesity groups. Even after adjustment for other potential confounders, the probability of being physically active (exercise time ≥ 120 minutes/week) was lower in children aged 9– 11 years (OR=0.86, 95% CI 0.78– 0.94, P< 0.01), but higher in children aged 12– 14 years (OR=1.91, 95% CI 1.69– 2.17, P< 0.01) and aged 15– 18 years (OR=2.22, 95% CI 1.85– 2.66, P< 0.01), when compared with children aged 6– 8 years.Conclusion: Children aged 9– 11 years had a higher prevalence of obesity, but a lower percentage of being physically active. Targeted intervention programs in this key group are needed to address this problem in China.Keywords: overweight, obesity, prevalence, risk factors, exercise time

Published
2021

48. Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Author

Schmaal, L, Hibar, DP, Sämann, PG, Hall, GB, Baune, BT, Jahanshad, N, Cheung, JW, van Erp, TGM, Bos, D, Ikram, MA, Vernooij, MW, Niessen, WJ, Tiemeier, H, Hofman, A, Wittfeld, K, Grabe, HJ, Janowitz, D, Bülow, R, Selonke, M, Völzke, H, Grotegerd, D, Dannlowski, U, Arolt, V, Opel, N, Heindel, W, Kugel, H, Hoehn, D, Czisch, M, Couvy-Duchesne, B, Rentería, ME, Strike, LT, Wright, MJ, Mills, NT, de Zubicaray, GI, McMahon, KL, Medland, SE, Martin, NG, Gillespie, NA, Goya-Maldonado, R, Gruber, O, Krämer, B, Hatton, SN, Lagopoulos, J, Hickie, IB, Frodl, T, Carballedo, A, Frey, EM, van Velzen, LS, Penninx, BWJH, van Tol, M-J, van der Wee, NJ, Davey, CG, Harrison, BJ, Mwangi, B, Cao, B, Soares, JC, Veer, IM, Walter, H, Schoepf, D, Zurowski, B, Konrad, C, Schramm, E, Normann, C, Schnell, K, Sacchet, MD, Gotlib, IH, MacQueen, GM, Godlewska, BR, Nickson, T, McIntosh, AM, Papmeyer, M, Whalley, HC, Hall, J, Sussmann, JE, Li, M, Walter, M, Aftanas, L, Brack, I, Bokhan, NA, Thompson, PM, and Veltman, DJ

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Clinical Sciences, Psychology, Major Depressive Disorder, Serious Mental Illness, Neurosciences, Biomedical Imaging, Depression, Basic Behavioral and Social Science, Mental Health, Brain Disorders, Clinical Research, Pediatric, Behavioral and Social Science, 2.3 Psychological, social and economic factors, Aetiology, 2.1 Biological and endogenous factors, Neurological, Mental health, Adolescent, Adult, Brain, Cerebral Cortex, Depressive Disorder, Major, Female, Frontal Lobe, Gray Matter, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neuroimaging, Prefrontal Cortex, Temporal Lobe, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.

Published
2017

49. Effects of sulfate and magnesium on cement degradation under geologic CO2 sequestration conditions

Author

Guo, J, Cao, B, Steefel, CI, Chen, J, and Hu, Y

Subjects
Geologic CO2 sequestration, Cement degradation, Sulfate, Magnesium, Gypsum, Calcite, Energy, Earth Sciences, Environmental Sciences, Engineering
Abstract

For safer geologic CO2 sequestration (GCS), it is important to understand CO2-brine-cement interactions, which affect wellbore integrity. However, potential effects of sulfate and magnesium ions on cement degradation under GCS conditions are not well understood. Here Class H Portland cement were reacted in brines containing 0.05 M sulfate and/or magnesium ions under both GCS (50 °C and 100 atm CO2) and control (50 °C and atmospheric pressure) conditions. Using optical microscopy and scanning electron microscope coupled with energy dispersive spectrometry and electron back scattered electron (SEM-EDS/BSE), slower cement carbonation rates were observed in the presence of sulfate under GCS conditions, because of gypsum precipitation on cement surfaces. Calcite rather than gypsum formed in both the inner layers of cement samples reacted under GCS conditions, and on cement surfaces reacted under atmospheric pressure conditions. Under GCS conditions, the dissolved CO2 lowered the pH of the solution surrounding cement surfaces, thus favoring the formation of gypsum over calcite on cement surfaces; while the high pH condition in pore solution inside cement favors the formation of calcite over gypsum. The presence of magnesium had no significant effect on cement degradation under GCS conditions, as brucite, magnesium carbonates and magnesium calcite did not form, due to the low pH at cement surface and the limited diffusion of Mg into cement inner layers.

Published
2017

50. The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening.

Author

Patrick, R, Naval-Sanchez, M, Deshpande, N, Huang, Y, Zhang, J, Chen, X, Yang, Y, Tiwari, K, Esmaeili, M, Tran, M, Mohamed, AR, Wang, B, Xia, D, Ma, J, Bayliss, J, Wong, K, Hun, ML, Sun, X, Cao, B, Cottle, DL, Catterall, T, Barzilai-Tutsch, H, Troskie, R-L, Chen, Z, Wise, AF, Saini, S, Soe, YM, Kumari, S, Sweet, MJ, Thomas, HE, Smyth, IM, Fletcher, AL, Knoblich, K, Watt, MJ, Alhomrani, M, Alsanie, W, Quinn, KM, Merson, TD, Chidgey, AP, Ricardo, SD, Yu, D, Jardé, T, Cheetham, SW, Marcelle, C, Nilsson, SK, Nguyen, Q, White, MD, Nefzger, CM, Patrick, R, Naval-Sanchez, M, Deshpande, N, Huang, Y, Zhang, J, Chen, X, Yang, Y, Tiwari, K, Esmaeili, M, Tran, M, Mohamed, AR, Wang, B, Xia, D, Ma, J, Bayliss, J, Wong, K, Hun, ML, Sun, X, Cao, B, Cottle, DL, Catterall, T, Barzilai-Tutsch, H, Troskie, R-L, Chen, Z, Wise, AF, Saini, S, Soe, YM, Kumari, S, Sweet, MJ, Thomas, HE, Smyth, IM, Fletcher, AL, Knoblich, K, Watt, MJ, Alhomrani, M, Alsanie, W, Quinn, KM, Merson, TD, Chidgey, AP, Ricardo, SD, Yu, D, Jardé, T, Cheetham, SW, Marcelle, C, Nilsson, SK, Nguyen, Q, White, MD, and Nefzger, CM

Abstract

A mechanistic connection between aging and development is largely unexplored. Through profiling age-related chromatin and transcriptional changes across 22 murine cell types, analyzed alongside previous mouse and human organismal maturation datasets, we uncovered a transcription factor binding site (TFBS) signature common to both processes. Early-life candidate cis-regulatory elements (cCREs), progressively losing accessibility during maturation and aging, are enriched for cell-type identity TFBSs. Conversely, cCREs gaining accessibility throughout life have a lower abundance of cell identity TFBSs but elevated activator protein 1 (AP-1) levels. We implicate TF redistribution toward these AP-1 TFBS-rich cCREs, in synergy with mild downregulation of cell identity TFs, as driving early-life cCRE accessibility loss and altering developmental and metabolic gene expression. Such remodeling can be triggered by elevating AP-1 or depleting repressive H3K27me3. We propose that AP-1-linked chromatin opening drives organismal maturation by disrupting cell identity TFBS-rich cCREs, thereby reprogramming transcriptome and cell function, a mechanism hijacked in aging through ongoing chromatin opening.

Published
2024

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