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33 results on '"Cao, Zhiling"'

9. In vitro and in vivo evaluation of a water‐in‐oil microemulsion of platycodin D

Author

Jinyang Shen, Bingxue Zhou, Cao Zhiling, Ji Jing, Di Zhang, Yuexia Zhu, Li Jiaojiao, Li Kong, and Ye Jin

Subjects
Male, Platycodon, Pharmaceutical Science, 01 natural sciences, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Microemulsion, Particle Size, Phospholipids, Chromatography, Aqueous solution, Ethanol, Viscosity, 010405 organic chemistry, Chemistry, Platycodin D, Water, Hydrogen-Ion Concentration, Saponins, Triterpenes, Rats, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Oleic acid, Intestinal Absorption, Permeability (electromagnetism), Area Under Curve, Emulsions, Titration, Soybeans, Half-Life, Oleic Acid
Abstract

Platycodin D (PD) is the active metabolite of Platycodon grandiflorum. The main purpose of this study was to develop and evaluate a water-in-oil (W/O) microemulsion formulation of PD (PD-ME). The PD-ME was successfully prepared by the water titration method at K m = 2, to draw the pseudoternary phase diagrams. Physical characterization including the particle size, pH, refractive index, average viscosity, and polydispersity index (PDI) was performed. The in vivo characteristics were evaluated by intestinal permeability and pharmacokinetic studies. The optimized microemulsion formulation consisted of 100 mg/ml PD aqueous solution, soybean phospholipids, ethanol, and oleic acid (27:39:19:15, w/w). The average viscosity, pH, droplet size, PDI, and zeta potential of the PD-ME were 78.65 ± 0.13 cPa•s, 5.70 ± 0.05, 30.46 ± 0.20 nm, 0.33 ± 0.00, and -3.13 mV, respectively. The drug concentration of the PD-ME was 26.3 ± 0.6 mg/ml. The PD-ME showed significantly higher apparent permeability coefficients than PD (p

Published
2021

30. A Convenient and Efficient Synthesis of 2-Thioxoquinazolinone Derivatives via.

Author

Liu, Weiwei, Zhang, Qiang, Gong, Feng, Cao, Zhiling, and Huo, Yunfeng

Subjects
ANHYDRIDES, AMINES, ELECTROSPRAY ionization mass spectrometry, HETEROCYCLIC compounds, HETEROCYCLIC chemistry
Abstract

The synthesis of 2-thioxoquinazolinone derivatives was achieved by condensation of isatoic anhydride, primary amine, and under . This convenient and efficient method affords the desired products with good to excellent yields. Satisfactory , 1H NMR, and high-resolution (electrospray ionization) spectra were obtained for all compounds described. [ABSTRACT FROM AUTHOR]

Published
2015
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31. A facile and stereoselective synthesis of 3,4,6-tri-O-acetyl-2-deoxy-2phthalimido-β-D-glucopyranosyl chloride.

Author

Cao, Zhiling, Liu, Wenjie, Qu, Yingying, Yao, Guowei, Gao, Dachao, and Liu, Weiwei

Subjects
*THALIDOMIDE, *ANOMERIC effect, *CHLORINATION, *THIONYL chloride, *LEWIS acids
Abstract

Acetylation of D-glucosamine catalysed by sulfuric acid and N-phthaloylation of the glucosyl acetate yielded 1,3,4,6-tetra-O-acetyl-2-deoxy-2-phthalimido-α-D-glucopyranose. This gave the corresponding pure β-glucosyl chloride upon treatment with PCl5-BF3. An anomeric chlorination with thionyl chloride combined with the Lewis acids (ZnCl2, SnCl4 and BiCl3) resulted in an α/β anomer mixture. [ABSTRACT FROM AUTHOR]

Published
2013
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32. Dimeth-yl(2-oxo-2-phenyl-eth-yl)sulfanium bromide.

Author

Cao Z, Liu W, and Yin F

Abstract

Single crystals of the title compound, C(10)H(13)OS(+)·Br(-), were obtained from ethyl acetate/ethyl ether after reaction of acetophenone with hydro-bromic acid and dimethyl-sulfoxide. The carbonyl group is almost coplanar with the neighbouring phenyl ring [O-C-C-C = 178.9 (2)°]. The sulfanium group shows a trigonal-pyramidal geometry at the S atom. The crystal structure is stabil-ized by C-H⋯Br hydrogen-bonding inter-actions. Weak π-π inter-actions link adjacent phenyl rings [centroid-centroid distance = 3.946 (2) Å].

Published
2010
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