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44 results on '"Cao, Xun-Jie"'

15. Additional file 9 of Identification of differentially expressed genes and signaling pathways with Candida infection by bioinformatics analysis

Author

Zhu, Guo-Dong, Xie, Li-Min, Su, Jian-Wen, Cao, Xun-Jie, Yin, Xin, Li, Ya-Ping, Gao, Yuan-Mei, and Guo, Xu-Guang

Abstract

Additional file 9: Figure S1. Construction of the PPI network from four groups of Candida. Candida albicans (A), Candida glabrata (B), Candida parapsilosis (C) and Candida tropicalis (D).

Published
2022
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27. Evaluation of RT-LAMP Assay for Rapid Detection of SARS-CoV-2.

Author

Li, Ya-Ping, Cao, Xun-Jie, Luo, Xin, Xie, Tian-Ao, Liu, Wan-Jun, Xie, Shi-Ming, Lin, Min, and Guo, Xu-Guang

Subjects
*ONLINE information services, *MEDICAL databases, *COVID-19, *MOLECULAR diagnosis, *META-analysis, *MEDICAL information storage & retrieval systems, *CONFIDENCE intervals, *SYSTEMATIC reviews, *COMMUNITY health services, *PRIMARY health care, *DESCRIPTIVE statistics, *COVID-19 testing, *SENSITIVITY & specificity (Statistics), *MEDLINE, *DATA analysis software, *ODDS ratio, *LOGISTIC regression analysis, *LOOP-mediated isothermal amplification, *EARLY diagnosis
Abstract

Objective To evaluate the accuracy of the reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in community or primary-care settings. Method We systematically searched the Web of Science, Embase, PubMed, and Cochrane Library databases. We conducted quality evaluation using ReviewManager software (version 5.0). We then used MetaDisc software (version 1.4) and Stata software (version 12.0) to build forest plots, along with a Deeks funnel plot and a bivariate boxplot for analysis. Result Overall, the sensitivity, specificity, and diagnostic odds ratio were 0.79, 0.97, and 328.18, respectively. The sensitivity for the subgroup with RNA extraction appeared to be higher, at 0.88 (0.86–0.90), compared to the subgroup without RNA extraction, at 0.50 (0.45–0.55), with no significant difference in specificity. Conclusion RT-LAMP assay exhibited high specificity regarding current SARS-CoV-2 infection. However, its overall sensitivity was relatively moderate. Extracting RNA was found to be beneficial in improving sensitivity. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Identification of differentially expressed genes and signaling pathways with Candidainfection by bioinformatics analysis

Author

Zhu, Guo-Dong, Xie, Li-Min, Su, Jian-Wen, Cao, Xun-Jie, Yin, Xin, Li, Ya-Ping, Gao, Yuan-Mei, and Guo, Xu-Guang

Abstract

Background: Opportunistic Candidaspecies causes severe infections when the human immune system is weakened, leading to high mortality. Methods: In our study, bioinformatics analysis was used to study the high-throughput sequencing data of samples infected with four kinds of Candidaspecies. And the hub genes were obtained by statistical analysis. Results: A total of 547, 422, 415 and 405 differentially expressed genes (DEGs) of Candida albicans, Candida glabrata, Candida parapsilosisand Candida tropicalisgroups were obtained, respectively. A total of 216 DEGs were obtained after taking intersections of DEGs from the four groups. A protein–protein interaction (PPI) network was established using these 216 genes. The top 10 hub genes (FOSB, EGR1, JUNB, ATF3, EGR2, NR4A1, NR4A2, DUSP1, BTG2, and EGR3) were acquired through calculation by the cytoHubbaplug-in in Cytoscape software. Validated by the sequencing data of peripheral blood, JUNB, ATF3 and EGR2 genes were  significant statistical significance. Conclusions: In conclusion, our study demonstrated the potential pathogenic genes in Candidaspecies and their underlying mechanisms by bioinformatic analysis methods. Further, after statistical validation, JUNB, ATF3 and EGR2 genes were attained, which may be used as potential biomarkers with Candidaspecies infection.

Published
2022
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