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BACKGROUND: Artificial Intelligence(AI)-based solutions for Gleason grading hold promise for pathologists, while image quality inconsistency, continuous data integration needs, and limited generalizability hinder their adoption and scalability. METHODS: We present a comprehensive digital pathology workflow for AI-assisted Gleason grading. It incorporates A!MagQC (image quality control), A!HistoClouds (cloud-based annotation), Pathologist-AI Interaction (PAI) for continuous model improvement, Trained on Akoya-scanned images only, the model utilizes color augmentation and image appearance migration to address scanner variations. We evaluate it on Whole Slide Images (WSI) from another five scanners and conduct validations with pathologists to assess AI efficacy and PAI. RESULTS: Our model achieves an average F1 score of 0.80 on annotations and 0.71 Quadratic Weighted Kappa on WSIs for Akoya-scanned images. Applying our generalization solution increases the average F1 score for Gleason pattern detection from 0.73 to 0.88 on images from other scanners. The model accelerates Gleason scoring time by 43% while maintaining accuracy. Additionally, PAI improve annotation efficiency by 2.5 times and led to further improvements in model performance. CONCLUSIONS: This pipeline represents a notable advancement in AI-assisted Gleason grading for improved consistency, accuracy, and efficiency. Unlike previous methods limited by scanner specificity, our model achieves outstanding performance across diverse scanners. This improvement paves the way for its seamless integration into clinical workflows.

AbstractWith increasing driving automation, driving tasks are shifting from drivers to automation systems and their roles are gradually changing from drivers to passengers. While efforts have been made to explore influencing factors of highly automated vehicles (HAVs) usage intention, few studies have linked role adaptation (RA) to variables from existing acceptance models. To fulfill this research gap, a HAV acceptance model was established based on RA, and other factors (i.e., situational trust, anxiety, and perceived usefulness [PU]). The proposed model validity was verified by subjective ratings collected from a driving simulator experiment involving 105 participants each of whom rode vehicles with three different automated driving styles. Results revealed that RA was an important factor in forming HAVs acceptance during initial human-automation interaction stages and could be increased by improving situational trust, PU, or reducing anxiety. Practically, these results can provide valuable guidance for enhancing consumers’ HAV acceptances. [ABSTRACT FROM AUTHOR]

In a typical traffic scenario, automated vehicles are required to interact with surrounding traffic participants, e.g. human-driven vehicles, pedestrians, etc. In this paper, a novel adaptive authority allocation strategy considering the social behaviours of surrounding vehicles is proposed for the shared steering control (SSC) of automated vehicles. First, a Koopman-based potential-field-driven distributed model predictive control (K-PF-DMPC) method is proposed for the modelling of vehicle interaction to describe surrounding vehicle's social behaviour. This method effectively deals with the nonlinearity embedded in the non-cooperative game-based vehicle interaction model, so that the analytical form of Nash equilibrium can be derived for a fast online solution. Then, the SSC system of the automated vehicle is implemented by a weighted summation method. To balance the driving performance and intervention degree while considering the surrounding vehicles' social behaviours, a hybrid fuzzy strategy (HFS) is proposed for allocating the control authority between the driver and automation. The value of authority allocation coefficient is calculated by fusing the outputs from two shared fuzzy controllers, i.e. the enhanced and weakened shared fuzzy controllers, in accordance to the belief of the surrounding vehicle's type. Several numerical simulations and driver-in-the-loop simulator experiments are conducted for validation. Results show that the proposed strategy can provide appropriate steering intervention to the driver owing to the consideration of the surrounding vehicle's social behaviour and obtains the best driver-automation collaboration performance compared with the comparative groups. [ABSTRACT FROM AUTHOR]

Objective: This paper proposes an objective method to measure and identify trust-change directions during takeover transitions (TTs) in conditionally automated vehicles (AVs). Background: Takeover requests (TORs) will be recurring events in conditionally automated driving that could undermine trust, and then lead to inappropriate reliance on conditionally AVs, such as misuse and disuse. Method: 34 drivers engaged in the non-driving-related task were involved in a sequence of takeover events in a driving simulator. The relationships and effects between drivers' physiological responses, takeover-related factors, and trust-change directions during TTs were explored by the combination of an unsupervised learning algorithm and statistical analyses. Furthermore, different typical machine learning methods were applied to establish recognition models of trust-change directions during TTs based on takeover-related factors and physiological parameters. Result: Combining the change values in the subjective trust rating and monitoring behavior before and after takeover can reliably measure trust-change directions during TTs. The statistical analysis results showed that physiological parameters (i.e., skin conductance and heart rate) during TTs are negatively linked with the trust-change directions. And drivers were more likely to increase trust during TTs when they were in longer TOR lead time, with more takeover frequencies, and dealing with the stationary vehicle scenario. More importantly, the F1-score of the random forest (RF) model is nearly 77.3%. Conclusion: The features investigated and the RF model developed can identify trust-change directions during TTs accurately. Application: Those findings can provide additional support for developing trust monitoring systems to mitigate both drivers' overtrust and undertrust in conditionally AVs. [ABSTRACT FROM AUTHOR]

The visibilities measured by radio astronomical interferometers include non-astronomical correlated signals that arise from the local environment of the array. These correlated signals are especially important in compact arrays such as those under development for 21 cm intensity mapping. The amplitudes of the contaminated visibilities can exceed the expected 21 cm signal and represent a significant systematic effect. We study the receiver noise radiated by antennas in compact arrays and develop a model for how it couples to other antennas. We apply the model to the Tianlai Dish Pathfinder Array (TDPA), a compact array of 16, 6-m dish antennas. The coupling model includes electromagnetic simulations, measurements with a network analyzer, and measurements of the noise of the receivers. We compare the model to drift-scan observations with the array and set requirements on the level of antenna cross-coupling for 21 cm intensity mapping instruments. We find that for the TDPA, cross-coupling would have to be reduced by three orders of magnitude in order to contribute negligibly to the visibilities. [ABSTRACT FROM AUTHOR]

Images of underwater environments suffer from contrast degradation, reduced clarity, and information attenuation. The traditional method is the global estimate of polarization. However, targets in water often have complex polarization properties. For low polarization regions, since the polarization is similar to the polarization of background, it is difficult to distinguish between target and non-targeted regions when using traditional methods. Therefore, this paper proposes a joint evaluation and partition fusion method. First, we use histogram stretching methods for preprocessing two polarized orthogonal images, which increases the image contrast and enhances the image detail information. Then, the target is partitioned according to the values of each pixel point of the polarization image, and the low and high polarization target regions are extracted based on polarization values. To address the practical problem, the low polarization region is recovered using the polarization difference method, and the high polarization region is recovered using the joint estimation of multiple optimization metrics. Finally, the low polarization and the high polarization regions are fused. Subjectively, the experimental results as a whole have been fully restored, and the information has been retained completely. Our method can fully recover the low polarization region, effectively remove the scattering effect and increase an image's contrast. Objectively, the results of the experimental evaluation indexes, EME, Entropy, and Contrast, show that our method performs significantly better than the other methods, which confirms the feasibility of this paper's algorithm for application in specific underwater scenarios. [ABSTRACT FROM AUTHOR]

Objective: Buccal mucosa cancer (BMC) is one of the most common oral cancers and has poor prognosis. The study aimed to develop and validate nomograms for predicting the 1‐, 3‐, and 5‐year overall survival (OS) and cancer‐specific survival (CSS) of BMC patients. Methods: We collected and reviewed information on BMC patients diagnosed between 2004 and 2019 from the Surveillance Epidemiology and End Results database. Two nomograms were developed and validated to predict the OS and CSS based on predictors identified by univariate and multivariate Cox regression. An extra external validation was further performed using data from Sun Yat‐sen Memorial Hospital (SYSMH). Results: A total of 3154 BMC patients included in this study were randomly assigned to training and validation groups in a 2:1 ratio. Independent prognostic predictors were identified, confirmed, and fitted into nomograms for OS and CSS, respectively. The C‐indices are 0.767 (Training group OS), 0.801 (Training group CSS), 0.763 (Validation group OS), and 0.781 (Validation group OS), respectively. Moreover, the nomograms exhibited remarkable precision in forecasting and significant clinical significance, as evidenced by receiver operating characteristic (ROC) curves, calibration curves, and decision curve analyses (DCA). The final validation using our data from SYSMH also showed high accuracy and substantial clinical benefits within the nomograms. The C‐indices are 0.849 (SYSMH group OS) and 0.916 (SYSMH group CSS). These indexes are better than tumor, node, and metastasis stage based on prediction results. Conclusions: The nomograms developed with great performance predicted 1‐, 3‐, and 5‐year OS and CSS of BMC patients. Use of the nomograms in clinical practices shall bring significant benefits to BMC patients. [ABSTRACT FROM AUTHOR]