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21 results on '"Cao, Guochun"'

2. Effects of sintilimab plus chemotherapy as first-line treatment on health-related quality of life in patients with advanced esophageal squamous cell carcinoma: results from the randomized phase 3 ORIENT-15 study

Author

Lu, Zhihao, Kong, Li, Wang, Buhai, Wang, Junye, Liu, Lianke, Shu, Yongqian, Yang, Lei, Sun, Guogui, Cao, Guochun, Ji, Yinghua, Cui, Tongjian, Liu, Hu, Qiu, Wensheng, Li, Na, Li, Gaofeng, Luo, Hui, Hou, Xinfang, Zhang, Yanqiao, Yue, Wenbin, Xue, Liying, Liu, Zheng, Pan, Yueyin, Gao, Shegan, Wang, Xiuwen, Pan, Zhanyu, Zhang, Shuqun, Lin, Gen, Xie, Yanru, Gu, Kangsheng, Ren, Tiejun, Li, Weidong, Li, Tao, Wang, Shoufeng, He, Wei, Fan, Yun, Liang, Jun, Xia, Bing, Zhao, Li, Wang, Shuxuan, and Shen, Lin

Published
2024
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4. 678 Updated safety and efficacy of toripalimab combined with cetuximab in platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC): a phase Ib/II clinical trial

Author

Guo, Ye, primary, Li, Zhendong, additional, Hu, Desheng, additional, Qu, Song, additional, Zhu, Youhua, additional, Fang, Meiyu, additional, Chen, Wantao, additional, Sun, Chuanzheng, additional, Jiang, Hao, additional, Zong, Jingfeng, additional, Lin, Jinguan, additional, Wang, Siyang, additional, Wang, Wei, additional, Jin, Chuan, additional, Cao, Guochun, additional, Ge, Minghua, additional, Huang, Xiaoming, additional, Wang, Xudong, additional, Li, Zhiming, additional, Wang, Mo, additional, Luo, Xianming, additional, Wei, Shuanghui, additional, and Shen, Yuteng, additional

Published
2023
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5. Expression of CircATXN7 in esophageal cancer tissues and its effect on cell proliferation and invasion

Author

Liu, Delin, Jia, Hui, Lu, Jianwei, Zou, Xi, Qian, Ting, Peng, Fanyu, Cao, Guochun, Wang, Min, and Liu, Shenlin

Subjects
Oncology, Gastroenterology, Original Article
Abstract

BACKGROUND: The goal of the current research was to investigate circATXN7 expression in esophageal cancer (EC) and its impact on the proliferation, migration, and invasion of EC cells. METHODS: Determination of circATXN7 expression in esophageal cancer tissues and adjacent tissueswas carried out using quantitative reverse transcription polymerase chain reaction (qRT-PCR), and we further analyzed the correlation between patients’ clinical characteristics and circATXN7 expression. EC cell lines (EC-9706, Eca-109, TE-1, KYSE-30, and KYSE-150) and normal esophageal cell line (HET-1A) were cultured, and circATXN7 expression was detected by qRT-PCR. The lowest circATXN7-containing Eca-109 cells were selected to be transfected with an overexpressing lentiviral vector (circATXN7). EC-9706 cells with the highest expression of circATXN7 were selected for transfection with knockdown vectors [short hairpin RNA (shRNA)#1 and shRNA#2] of the circATXN7 sequence. Cell proliferation was determined via MTT assay. The formation of cell clones was investigated via colony formation assay. Transwell migration assay was utilized to determine cell migration and invasion ability. RESULTS: Significantly higher levels of circATXN7 were observed in EC tissues compared with paracancerous tissues (P

Published
2022

6. Abstract CT075: Updated overall survival outcomes from a randomized, double-blind phase III study of sintilimab versus placebo in combination with chemotherapy as first-line treatment for advanced esophageal squamous cell carcinoma (ORIENT-15)

Author

Lu, Zhihao, primary, Wang, Junye, additional, Shu, Yongqian, additional, Kong, Li, additional, Wang, Buhai, additional, Yang, Lei, additional, Cao, Guochun, additional, Sun, Guogui, additional, Ji, Yinghua, additional, Liu, Hu, additional, Cui, Tongjian, additional, Qiu, Wensheng, additional, Zaanan, Aziz, additional, Cid, Roberto Pazo, additional, Zhou, Hui, additional, Sun, Xing, additional, Wang, Yan, additional, Chen, Yuling, additional, Li, Haoyuan, additional, Zhang, Lishi, additional, and Shen, Lin, additional

Published
2023
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8. SCALE-1: Safety and efficacy of short course neoadjuvant chemo-radiotherapy plus toripalimab for locally advanced resectable squamous cell carcinoma of esophagus.

Author

Jiang, Ning, primary, Jiang, Ming, additional, Zhu, Xiangzhi, additional, Ren, Binhui, additional, Zhang, Jingyuan, additional, Guo, Zhen, additional, Wu, Yinan, additional, Song, Xue, additional, Zhao, Lijun, additional, Kong, Cheng, additional, Zong, Dan, additional, Cao, Guochun, additional, Qian, Pudong, additional, Zhao, Yang, additional, Li, Si, additional, and Luo, Shifu, additional

Published
2022
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9. Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial

Author

Lu, Zhihao, primary, Wang, Junye, additional, Shu, Yongqian, additional, Liu, Lianke, additional, Kong, Li, additional, Yang, Lei, additional, Wang, Buhai, additional, Sun, Guogui, additional, Ji, Yinghua, additional, Cao, Guochun, additional, Liu, Hu, additional, Cui, Tongjian, additional, Li, Na, additional, Qiu, Wensheng, additional, Li, Gaofeng, additional, Hou, Xinfang, additional, Luo, Hui, additional, Xue, Liying, additional, Zhang, Yanqiao, additional, Yue, Wenbin, additional, Liu, Zheng, additional, Wang, Xiuwen, additional, Gao, Shegan, additional, Pan, Yueyin, additional, Galais, Marie-Pierre, additional, Zaanan, Aziz, additional, Ma, Zhuo, additional, Li, Haoyu, additional, Wang, Yan, additional, and Shen, Lin, additional

Published
2022
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10. STAT3/c-Myc Axis-Mediated Metabolism Alternations of Inflammation-Related Glycolysis Involve with Colorectal Carcinogenesis

Author

Haibin Shen, Li Jie, Ying Zhu, Zhe Li, Cao Guochun, Zhenggang Yue, Pei Xie, Zhang Sha, and Ting Zang

Subjects
0301 basic medicine, Aging, Glucose uptake, Metabolic disorder, Inflammation, medicine.disease, Metabolism disorder, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Downregulation and upregulation, Lactate dehydrogenase, medicine, Cancer research, Glycolysis, Geriatrics and Gerontology, medicine.symptom, Colitis, 030217 neurology & neurosurgery
Abstract

Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC). It is extensively acknowledged that patients who have long-standing inflammation bowel disease are at high risk for developing CAC. However, the metabolic alteration by which chronic intestinal inflammation promotes colorectal cancer is unclear. In the present study, we constructed dextran sulfate sodium (DSS)-induced colitis mouse model to uncover possible alterations in the metabolism indexes. Interestingly, after DSS diet administration, the expression of metabolism indexes and c-Myc increased. Moreover, in vitro, we treated cells with IL-6 to simulate inflammatory microenvironment and found that glucose uptake, lactate production, and lactate dehydrogenase activity increased dramatically, mirroring what were observed in vivo. In addition, the associative inhibition of STAT3 and c-Myc could significantly block the expression of metabolic enzymes. With the inhibition of STAT3/c-Myc signaling, meanwhile, the upregulation of both cell glucose uptake and lactate production by IL-6 pretreatment was reduced simultaneously. Thus, our study indicates that inflammation could induce metabolic disorder by promoting STAT3 signaling and c-Myc activity. Collectively, we find that metabolic disruptions triggered by inflammatory signaling are associated with tumorigenesis via the STAT3/c-Myc axis.

Published
2019

21. The expression and location of midkine in gastric carcinomas of Chinese patients.

Author

Huang Y, Cao G, Wang H, Wang Q, and Hou Y

Subjects
Biomarkers, Tumor genetics, Case-Control Studies, Cell Nucleolus chemistry, Cell Nucleus chemistry, China, Cytokines genetics, Cytoplasm chemistry, Female, Humans, Immunohistochemistry, Male, Middle Aged, Midkine, Neoplasm Staging, RNA, Messenger analysis, Reproducibility of Results, Reverse Transcriptase Polymerase Chain Reaction, Stomach Neoplasms genetics, Stomach Neoplasms pathology, Biomarkers, Tumor analysis, Cytokines analysis, Gene Expression Regulation, Neoplastic, Stomach Neoplasms chemistry
Abstract

Midkine (MK), a heparin-binding growth factor, can regulate cell growth, survival and differentiation. MK is expressed at high levels in a variety of human carcinomas. Recently, the urine and serum MK concentration was analyzed in gastric cancer patient. However, the association of the cytokine mRNA expression with the categorical clinicopathological variables of the tumors and the location of its protein expression in the tumor tissues are still elusive. MK mRNA expression from the surgically resected specimens of healthy gastric tissues (9 cases), gastric cancer tissues and the matched non-cancerous tissues adjacent to the cancer (37 cases) were assessed by reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR. Immunohistochemical analysis was performed to locate MK in gastric cancer. The expression of MK mRNA in gastric cancer was much higher in tumor tissues than that in the non-cancerous tissues and control tissue samples. And its expression was significantly associated with the pTNM stage and distant metastasis, but not with the differentiation grade, tumor size and nodal involvement. MK protein was ubiquitous in the tumor, especially in the adenoid part of tumors. In addition, it was found in the cytoplasm of tumor cells and highly concentrated in nucleus and nucleolus. The expression level and location of MK in gastric tumor tissues of Chinese patients may be related to the tumor genesis and progression. Further study is necessary on the mechanism of MK in gastric tumorigenesis and tumor growth.

Published
2007

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