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Objective. BEP (bleomycin, etoposide, and cisplatin) chemotherapy is a standard regimen for germ cell tumors (GCTs); however, their high emetogenicity is problematic. The control of chemotherapy‐induced nausea and vomiting (CINV) is crucial to complete the treatment. We conducted this study to explore the efficacy and safety of antiemetic therapy with dexamethasone and aprepitant for 5 days in combination with palonosetron 0.75 mg on days 1 and 5 in BEP. Methods. This open‐label single‐arm study was prospectively conducted in 4 hospitals. Chemotherapy‐naïve men with GCT who were scheduled to receive the BEP regimen were eligible. The primary endpoint was the complete response (CR) rate of CINV. Results. A total of 19 patients were enrolled. Overall, 16 (84.2%) patients experienced some nausea, whereas only 4 (21.1%) patients had grade 1 emetic events. Overall CR of CINV was achieved in 9 (47.4%) patients. Although 14 (73.7%) patients experienced 22 adverse events after palonosetron administration, severe adverse events (grade 3 or more) attributable to it did not occur. Conclusion. The results suggest that aprepitant, palonosetron, and dexamethasone antiemetic therapy for patients with GCT receiving BEP is safe, whereas the efficacy of additional palonosetron administration on day 5 for prevention of delayed CINV remains unclear. This trial is registered with UMIN000008110. [ABSTRACT FROM AUTHOR]

Background. The involvement of women, as health influencers, has been instrumental in improving health outcomes and quality of life. In sub‐Saharan Africa, poor knowledge, attitudes, and beliefs about cancers have contributed to late detection and increased mortality. Although pharmacists have provided optimum pharmaceutical care in ensuring that prostate cancer (PCa) patients obtain maximum clinical benefits from pharmacotherapy, late detection has hindered pharmacotherapeutic outcomes. The application of the PCaKAB‐Gh tool to women has the potential to investigate their lapses in PCa knowledge, attitudes, and beliefs and further equip pharmacists and other healthcare professionals to design educational interventions. Ultimately, Ghanaian women will be well‐positioned to advise and motivate their men to screen for PCa. Method. Our pilot and psychometric studies recruited 400 and 500 participants from the Kumasi Central Market and the New Agogo Community Market, respectively. In this large population application of the PCaKAB‐Gh tool, 2000 women were simply randomly enrolled from these markets and data were collected using paper questionnaires with ethical approval. Data were entered into IBM SPSS (version 24) after cleaning and coding for analysis. The knowledge on signs and symptoms was scored and graded as "low" (≤2), "moderate" (3–5), and "high" (5–8), whilst the knowledge on causes and risk factors was stratified as "low" (≤1), "moderate" (2‐3), and "high" (4‐5). Pearson's correlation was conducted to investigate the relationship between women's educational status and knowledge, attitudes, and beliefs. Statistical significance was established as a p < 0.05. Results. Christians and Muslims accounted for about 70% and 24% of the participants, respectively, whilst over 50% of the participants were Akans. Over 50% and 30% of the 2000 participants had high and moderate knowledge about the signs and symptoms of PCa, respectively. Knowledge about the causes and risk factors was approximately 30% high and 50% moderate amongst the participants. Negative attitudes and beliefs outcomes were observed in about 25% and 55% of the participants. A p < 0.001 was achieved in Pearson's correlation between the educational level of respondents and knowledge on signs and symptoms (r = −0.102), knowledge on causes and risk factors (r = 0.111), attitudes (r = −0.122), and beliefs (r = 0.228). Conclusions. Our study established that market women had better knowledge on the signs and symptoms of PCa compared to the causes and risk factors. Their beliefs about PCa were worse compared to their attitudes. The development and administration of educational interventions, relying on the outcomes of this study, must involve markets, churches, and mosques as educational sites with special attention to addressing negative beliefs through a broader community‐based engagement. [ABSTRACT FROM AUTHOR]

Purpose. To investigate patient perceptions of physical rehabilitation received for various adverse physical effects following breast cancer surgery and the content and delivery methods of the physical rehabilitation received. Methods. Cross‐sectional study of 509 Australian women living with breast cancer (n = 178 (35%) (Breast Conserving Surgery (BCS)), n = 168 (33%) (Mastectomy (MAST)), and n = 163 (32%) (Breast Reconstruction Surgery (BRS)). Retrospective, online survey investigated the physical rehabilitation received after surgery/treatment. The survey explored the respondents′ perceptions (open response) and satisfaction levels with the physical rehabilitation received and its content and delivery method (closed responses). Perceptions were analyzed using a thematic analysis; satisfaction levels and delivery methods for each adverse physical effect were tabulated. Results. Major perceptions: (i) unaware of and unprepared for adverse physical effects, (ii) unsuitable information delivery, and (iii) insufficient follow‐up from health professionals. Physical rehabilitation content focused on shoulder issues and lymphedema; less than half of respondents received any information about scars, torso, and donor site issues or physical discomfort disturbing sleep. The proportion that received each delivery method varied for each adverse physical effect. Pamphlets and verbal instruction were the most common delivery methods and sessions with health professionals where issues were physically assessed, checked, or progressed the least common. Satisfaction levels varied for each adverse physical effect; all were less than 50%. Conclusion. Women perceived their physical rehabilitation did not prepare them for the adverse physical effects they experienced, the method and timing of delivery did not meet their needs at various stages of recovery, and the follow‐up was insufficient. Quantitative data on the content and delivery method support these perceptions. Explanations of why these perceptions occurred and recommendations to improve physical rehabilitation through greater use of patient‐related outcome measures and spreading limited physical rehabilitation resources using a three‐level model of care are recommended. Although many women recover from breast cancer, improved physical rehabilitation could enable women to manage any immediate or long‐term side effects of their breast cancer surgery and treatment. [ABSTRACT FROM AUTHOR]

Background. A timely diagnosis of cancer is important for patient outcomes. The delay in the patient interval (time from symptom interpretation to seeking help) is often the longest throughout the cancer patient pathway. Factors extending this interval include vague symptom profiles increasing the difficulty of symptom appraisal and individual demographics influencing help‐seeking behaviours. An underexplored and potential source of delay in cancer diagnosis is associated with managing symptoms using self‐care activities prior to presentation to healthcare. Methods. This study aimed to characterise the use of self‐care activities in the context of managing nonspecific symptoms, prior to cancer diagnosis and their effect on the length of the patient interval. Eligible publications were identified using a rapid systematic review, and their qualitative self‐care data were extracted and analysed using thematic synthesis. Results. Forty‐five qualitative research papers between 2009 and 2024 were included in the final review. Self‐care was used as part of an iterative process, often resulting in delayed presentation to healthcare, if methods were effective in managing nonspecific symptoms. Across the literature, varying types of self‐care activities were reported across all cancers with nonspecific symptoms, including the use of over‐the‐counter or alternative medications, lifestyle changes, and watchful waiting. The individual's decision to self‐care was either prompted externally by a healthcare professional (HCP) (e.g., community pharmacists) or prompted by the individual depending on the availability of home remedies and medication. Patients used self‐care when there was a low perceived need to seek healthcare, to determine whether healthcare was required, or to avoid the use of healthcare. However, across the literature, there is limited evidence to understand the variation by cancer type, symptoms, and individual characteristics. Conclusions. The findings of this rapid review demonstrate that self‐care activities could hinder prompt help‐seeking and delay cancer diagnosis among people who are experiencing nonspecific cancer symptoms. However, more evidence is needed to understand which individual factors facilitate the adoption of self‐care behaviours over prompt help‐seeking for nonspecific cancer symptoms. [ABSTRACT FROM AUTHOR]