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3. Learning from post-COVID-19 condition for epidemic preparedness: a variable catalogue for future post-acute infection syndromes

Author

Górska, Anna, Canziani, Lorenzo Maria, Rinaldi, Eugenia, Pana, Zoi D., Beale, Sarah, Bai, Francesca, Boxma-de Klerk, Bianca M., de Bruijn, Simeon, Donà, Daniele, Ekkelenkamp, Miquel B., Incardona, Francesca, Mallon, Patrick, Marchetti, Giulia C., Puhan, Milo, Riva, Agostino, Simensen, Victoria C., Vaillant, Michel, van der Zalm, Marieke M., van Kuijk, Sander M.J., Wingerden, Sophie van, Judd, Ali, Tacconelli, Evelina, and Peñalvo, José L.

Published
2024
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4. Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author

Pinho Guedes, Mariana Nunes, Maccarrone, Gaia, Pezzani, Maria Diletta, Sibani, Marcella, Davies, Ruth Joanna, Vitali, Stefania, Franchina, Giorgia, Tomassini, Giorgia, Sciammarella, Concetta, Cecchetto, Riccardo, Gibellini, Davide, De Toffoli, Chiara Konishi, Rosini, Giulia, Perlini, Chiara, Meroi, Marco, Cioli Puviani, Filippo, Fasan, Daniele, Micheletto, Claudio, Montemezzi, Stefania, Cardobi, Nicolò, Vantini, Gianluca, Mazzali, Gloria, Stabile, Giovanni, Marcanti, Maddalena, Zonta, Marco Pattaro, Calì, Deborah, Mason, Anna, Perlini, Cinzia, Gisondi, Paolo, Mongardi, Maria, Sorbello, Simona, Wold, Karin I., Vincenti-González, María F., Veloo, Alida C.M., Harmsma, Valerie P.R., Pantano, Daniele, van der Meer, Margriet, Gard, Lilli, Lizarazo, Erley F., Knoester, Marjolein, Friedrich, Alex W., Niesters, Hubert G.M., Viale, Pierluigi, Marzolla, Domenico, Cosentino, Federica, Di Chiara, Michela, Fornaro, Giacomo, Bonazzetti, Cecilia, Tazza, Beatrice, Toschi, Alice, Vetamanu, Oana, Giacomini, Maria Eugenia, Trapani, Fabio, Marconi, Lorenzo, Attard, Luciano, Tedeschi, Sara, Gabrielli, Liliana, Lazzarotto, Tiziana, Olivares, Paula, Castilla, Javier, Vélez, Javier, Almadana, Virginia, Martín-Barrera, Lucía, Martín-Gutiérrez, Ana Belén, Gutiérrez-Campos, David, Fernández-Regaña, Marta, Silva-Campos, Ana, Fernández-Riejos, Patricia, García-Sánchez, M. Isabel, Giuliano, Carla V., López, Carlota, Neumann, Gabriela, Camporro, Julieta, de Vedia, Lautaro, Agugliaro, Hugo, Scipione, Gabriella, Dellacasa, Chiara, Chandramouli, Balasubramanian, Gioiosa, Silvia, Naranjo, Juan Mata, Ortali, Maurizio, Konnova, Angelina, Gupta, Akshita, Smet, Mathias, Hotterbeekx, An, Berkell, Matilda, Sicuri, Elisa, Bachelet, Delphine, Bouadma, Lila, Cervantes-Gonzalez, Minerva, Chair, Anissa, Charpentier, Charlotte, Chenard, Léo, Descamps, Diane, Doan, Hang, Duval, Xavier, Esposito-Farese, Marina, Hoffmann, Isabelle, Kafif, Ouifiya, Le Hingrat, Quentin, Letrou, Sophie, Mentré, France, Schneider, Marion, Tardivon, Coralie, Timsit, Jean-Francois, Tubiana, Sarah, Abrous, Amal, Couffin-Cadiergues, Sandrine, Da Silva, Fernanda Dias, Esperou, Hélène, Houas, Ikram, Jaafoura, Salma, Papadopoulos, Aurélie, Ansart, Severine, Auvet, Adrien, Bani-Sadr, Firouzé, Bernard, L., Bissuel, François, Botelho-Nevers, Elisabeth, Bouhour, Damien, Cabié, André, Caraux Paz, Pauline, Chidiac, Christian, Chirouze, Catherine, Chroboczek, Tomasz, Cordel, Hugues, Courtois, Roxane, De Castro, Nathalie, Diamamntis, Sylvain, Diehl, Jean-Luc, Djossou, Felix, Dorival, Céline, Epaulard, Olivier, Gaborieau, Valerie, Goehringer, François, Gousseff, Marie, Jamard, Simon, Joseph, Cedric, Lacombe, Karine, Le Mestre, Soizic, Le Moing, Vincent, Lelievre, Jean-Daniel, Lesens, Olivier, Machado, M., Maillet, Mylène, Manda, Victoria, Martin-Blondel, Guillaume, Martinot, Martin, Meysonnier, Vanina, Molina, Jean-Michel, Oziol, Eric, Pestre, Vincent, Piroth, Lionel, Poissy, Julien, Rabaud, Christian, Raffi, François, Rammaert, Blandine, Rapp, Christophe, Rebaudet, Stanislas, Roger, Pierre-Marie, Roux, Damien, Senneville, Eric, Tattevin, Pierre, Wiedemann, Aurélie, Zucman, David, Gentilotti, Elisa, Górska, Anna, Tami, Adriana, Gusinow, Roy, Mirandola, Massimo, Rodríguez Baño, Jesús, Palacios Baena, Zaira R., Rossi, Elisa, Hasenauer, Jan, Lopes-Rafegas, Iris, Righi, Elda, Caroccia, Natascia, Cataudella, Salvatore, Pasquini, Zeno, Osmo, Thomas, Del Piccolo, Lidia, Savoldi, Alessia, Kumar-Singh, Samir, Mazzaferri, Fulvia, Caponcello, Maria Giulia, de Boer, Gerolf, Hara, Gabriel Levy, De Nardo, Pasquale, Malhotra, Surbhi, Canziani, Lorenzo Maria, Ghosn, Jade, Florence, Aline-Marie, Lafhej, Nadhem, van der Gun, Bernardina T.F., Giannella, Maddalena, Laouénan, Cédric, and Tacconelli, Evelina

Published
2023
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7. Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome.

Author

Gentilotti, Elisa, Gorska, Anna, Cecchini, Maria Paola, Mirandola, Massimo, Meroi, Marco, De Nardo, Pasquale, Sartori, Andrea, De Toffoli, Chiara Konishi, Kumar-Singh, Samir, Zanusso, Gianluigi, Monaco, Salvatore, Tacconelli, Evelina, Guedes, Mariana Nunes Pinho, Maccarrone, Gaia, Canziani, Lorenzo Maria, Davies, Ruth Joanna, Vitali, Stefania, Tomassini, Giorgia, Barana, Benedetta, and Pezzani, Maria Diletta

Subjects
POST-acute COVID-19 syndrome, COVID-19, OLFACTORY training, COVID-19 pandemic, QUALITY of life
Abstract

COVID-19 pandemic brought chemosensory impairment to the forefront of medicine, revealing gaps in the knowledge of pathophysiological mechanisms, true prevalence and preventive/therapeutic alternatives. This is a sub-study of the ORCHESTRA cohort focusing on post-COVID-19 chemosensory symptoms. Risk factors for neurosensorial cluster of post-COVID-19 syndrome (NSc-PCS) were assessed through multivariable analysis. Psychophysical validated tests were applied on a sub-population of 50 patients. Qualitative chemosensory symptoms as well as nasal and oral chemesthesis were evaluated through anamnestic interview and the quality of life through the SF-36 questionnaire. Chemosensory symptoms evolution and olfactory training's outcome were assessed through phone-call interviews. Out of 1187 patients (female, N = 630), 550 (47%) presented NSc-PCS, with a lower risk for older age and monoclonal antibodies treatment, and a higher risk in females (p < 0.001). Out of the 50 patients evaluated with psychophysical tests, 66% showed smell reduction with a qualitative alteration in 50% of hyposmic and 35% of normosmic patients. Hypogeusia was present in 14 (28%) of the patients assessed, with 56% showing a qualitative alteration; 53% of normogeusic patients presented qualitative disorders. NSc-PCS has a complex, fluctuating, multifaceted presentation. Quantifying and characterizing COVID-19-related chemosensory impairment is key to understand underlying mechanisms and to develop preventive and therapeutic treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Use of Azithromycin Attributable to Acute SARS‐CoV‐2 Infection.

Author

Gagliotti, Carlo, Banchelli, Federico, Buttazzi, Rossella, Ricchizzi, Enrico, Canziani, Lorenzo Maria, Rolli, Maurizia, Tacconelli, Evelina, Moro, Maria Luisa, and Berti, Elena

Abstract

Purpose: In the early stages of the COVID‐19 pandemic, preliminary results that later proved to be incorrect suggested the possible efficacy of anti‐infective drugs such as azithromycin for the treatment of SARS‐CoV‐2 infection. These preliminary data may have influenced the prescription of azithromycin. However, no individual‐level data linking the use of this antibiotic to acute SARS‐CoV‐2 infection are available. The present analysis aims to fill this gap. Methods: A retrospective population‐based cohort design was used including patients diagnosed with SARS‐CoV‐2 infection in the period ranging from February 2020 to February 2022. The data source for antibiotic consumption was the drug database of outpatient prescriptions of Emilia‐Romagna Region (Italy). Antibiotics were classified according to the Anatomical Therapeutic Chemical (ATC) classification system. Consumption rates and percentages of azithromycin DDDs (defined daily doses) during the acute phase of the infection were compared with a previous control period and with the post‐acute phase. Analyses were stratified by four groups according to the prevalent virus variant at time of diagnosis. Results: Comparing the previous control period with the acute phase of infections, the rates of azithromycin consumption (DDD per 1000 individuals per day) increased from 1.17 to 23.11, from 0.80 to 33.03, from 0.81 to 21.01, and from 1.02 to 9.76, in the pre‐Alpha, Alpha, Delta, and Omicron periods, respectively. Similarly, the percentages of individuals receiving azithromycin, and the azithromycin DDDs percentages over total systemic antibiotics DDDs increased in acute phases of infection compared with control periods. The consumption rates and percentages returned to preinfection levels in the post‐acute phase. In the study period, 12.9% of the use of azithromycin in the entire adult population of Emilia‐Romagna was attributable to acute SARS‐CoV‐2 infection. Conclusions: Considering the low likelihood of bacterial coinfections, the increased azithromycin consumption in the acute phase of SARS‐CoV‐2 infection suggests inappropriate prescribing of this antibiotic. [ABSTRACT FROM AUTHOR]

Published
2024
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9. The incidence and risk factors of selected drug prescriptions and outpatient care after SARS-CoV-2 infection in low-risk subjects: a multicenter population-based cohort study

Author

Gagliotti, Carlo, primary, Banchelli, Federico, additional, De Paoli, Angela, additional, Buttazzi, Rossella, additional, Narne, Elena, additional, Ricchizzi, Enrico, additional, Schievano, Elena, additional, Bellio, Stefania, additional, Pitter, Gisella, additional, Tonon, Michele, additional, Canziani, Lorenzo Maria, additional, Rolli, Maurizia, additional, Tacconelli, Evelina, additional, Berti, Elena, additional, Russo, Francesca, additional, and Moro, Maria Luisa, additional

Published
2023
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10. How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

Author

Azzini, Anna Maria, primary, Canziani, Lorenzo Maria, additional, Davis, Ruth Joanna, additional, Mirandola, Massimo, additional, Hoelscher, Michael, additional, Meyer, Laurence, additional, Laouénan, Cédric, additional, Giannella, Maddalena, additional, Rodríguez-Baño, Jesús, additional, Boffetta, Paolo, additional, Mates, Dana, additional, Malhotra-Kumar, Surbhi, additional, Scipione, Gabriella, additional, Stellmach, Caroline, additional, Rinaldi, Eugenia, additional, Hasenauer, Jan, additional, and Tacconelli, Evelina, additional

Published
2023
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11. Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author

Gentilotti, Elisa, primary, Górska, Anna, additional, Tami, Adriana, additional, Gusinow, Roy, additional, Mirandola, Massimo, additional, Rodríguez Baño, Jesús, additional, Palacios Baena, Zaira R., additional, Rossi, Elisa, additional, Hasenauer, Jan, additional, Lopes-Rafegas, Iris, additional, Righi, Elda, additional, Caroccia, Natascia, additional, Cataudella, Salvatore, additional, Pasquini, Zeno, additional, Osmo, Thomas, additional, Del Piccolo, Lidia, additional, Savoldi, Alessia, additional, Kumar-Singh, Samir, additional, Mazzaferri, Fulvia, additional, Caponcello, Maria Giulia, additional, de Boer, Gerolf, additional, Hara, Gabriel Levy, additional, De Nardo, Pasquale, additional, Malhotra, Surbhi, additional, Canziani, Lorenzo Maria, additional, Ghosn, Jade, additional, Florence, Aline-Marie, additional, Lafhej, Nadhem, additional, van der Gun, Bernardina T.F., additional, Giannella, Maddalena, additional, Laouénan, Cédric, additional, Tacconelli, Evelina, additional, Pinho Guedes, Mariana Nunes, additional, Maccarrone, Gaia, additional, Pezzani, Maria Diletta, additional, Sibani, Marcella, additional, Davies, Ruth Joanna, additional, Vitali, Stefania, additional, Franchina, Giorgia, additional, Tomassini, Giorgia, additional, Sciammarella, Concetta, additional, Cecchetto, Riccardo, additional, Gibellini, Davide, additional, De Toffoli, Chiara Konishi, additional, Rosini, Giulia, additional, Perlini, Chiara, additional, Meroi, Marco, additional, Puviani, Filippo Cioli, additional, Fasan, Daniele, additional, Micheletto, Claudio, additional, Montemezzi, Stefania, additional, Cardobi, Nicolò, additional, Vantini, Gianluca, additional, Mazzali, Gloria, additional, Stabile, Giovanni, additional, Marcanti, Maddalena, additional, Zonta, Marco Pattaro, additional, Calì, Deborah, additional, Mason, Anna, additional, Perlini, Cinzia, additional, Gisondi, Paolo, additional, Mongardi, Maria, additional, Sorbello, Simona, additional, Wold, Karin I., additional, Vincenti-González, María F., additional, Veloo, Alida C.M., additional, Harmsma, Valerie P.R., additional, Pantano, Daniele, additional, van der Meer, Margriet, additional, Gard, Lilli, additional, Lizarazo, Erley F., additional, Knoester, Marjolein, additional, Friedrich, Alex W., additional, Niesters, Hubert G.M., additional, Viale, Pierluigi, additional, Marzolla, Domenico, additional, Cosentino, Federica, additional, Di Chiara, Michela, additional, Fornaro, Giacomo, additional, Bonazzetti, Cecilia, additional, Tazza, Beatrice, additional, Toschi, Alice, additional, Vetamanu, Oana, additional, Giacomini, Maria Eugenia, additional, Trapani, Fabio, additional, Marconi, Lorenzo, additional, Attard, Luciano, additional, Tedeschi, Sara, additional, Gabrielli, Liliana, additional, Lazzarotto, Tiziana, additional, Olivares, Paula, additional, Castilla, Javier, additional, Vélez, Javier, additional, Almadana, Virginia, additional, Martín-Barrera, Lucía, additional, Martín-Gutiérrez, Ana Belén, additional, Gutiérrez-Campos, David, additional, Fernández-Regaña, Marta, additional, Silva-Campos, Ana, additional, Fernández-Riejos, Patricia, additional, García-Sánchez, M. Isabel, additional, Giuliano, Carla V., additional, López, Carlota, additional, Neumann, Gabriela, additional, Camporro, Julieta, additional, de Vedia, Lautaro, additional, Agugliaro, Hugo, additional, Scipione, Gabriella, additional, Dellacasa, Chiara, additional, Chandramouli, Balasubramanian, additional, Gioiosa, Silvia, additional, Naranjo, Juan Mata, additional, Ortali, Maurizio, additional, Konnova, Angelina, additional, Gupta, Akshita, additional, Smet, Mathias, additional, Hotterbeekx, An, additional, Berkell, Matilda, additional, Sicuri, Elisa, additional, Bachelet, Delphine, additional, Bouadma, Lila, additional, Cervantes-Gonzalez, Minerva, additional, Chair, Anissa, additional, Charpentier, Charlotte, additional, Chenard, Léo, additional, Descamps, Diane, additional, Doan, Hang, additional, Duval, Xavier, additional, Esposito-Farese, Marina, additional, Hoffmann, Isabelle, additional, Kafif, Ouifiya, additional, Le Hingrat, Quentin, additional, Letrou, Sophie, additional, Mentré, France, additional, Schneider, Marion, additional, Tardivon, Coralie, additional, Timsit, Jean-Francois, additional, Tubiana, Sarah, additional, Abrous, Amal, additional, Couffin-Cadiergues, Sandrine, additional, Da Silva, Fernanda Dias, additional, Esperou, Hélène, additional, Houas, Ikram, additional, Jaafoura, Salma, additional, Papadopoulos, Aurélie, additional, Ansart, Severine, additional, Auvet, Adrien, additional, Bani-Sadr, Firouzé, additional, Bernard, L., additional, Bissuel, François, additional, Botelho-Nevers, Elisabeth, additional, Bouhour, Damien, additional, Cabié, André, additional, Caraux Paz, Pauline, additional, Chidiac, Christian, additional, Chirouze, Catherine, additional, Chroboczek, Tomasz, additional, Cordel, Hugues, additional, Courtois, Roxane, additional, De Castro, Nathalie, additional, Diamamntis, Sylvain, additional, Diehl, Jean-Luc, additional, Djossou, Felix, additional, Dorival, Céline, additional, Epaulard, Olivier, additional, Gaborieau, Valerie, additional, Goehringer, François, additional, Gousseff, Marie, additional, Jamard, Simon, additional, Joseph, Cedric, additional, Lacombe, Karine, additional, Le Mestre, Soizic, additional, Le Moing, Vincent, additional, Lelievre, Jean-Daniel, additional, Lesens, Olivier, additional, Machado, M., additional, Maillet, Mylène, additional, Manda, Victoria, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Meysonnier, Vanina, additional, Molina, Jean-Michel, additional, Oziol, Eric, additional, Pestre, Vincent, additional, Piroth, Lionel, additional, Poissy, Julien, additional, Rabaud, Christian, additional, Raffi, François, additional, Rammaert, Blandine, additional, Rapp, Christophe, additional, Rebaudet, Stanislas, additional, Roger, Pierre-Marie, additional, Roux, Damien, additional, Senneville, Eric, additional, Tattevin, Pierre, additional, Wiedemann, Aurélie, additional, and Zucman, David, additional

Published
2023
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12. How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

Author

European Commission, Azzini, Anna Maria, Canziani, Lorenzo Maria, Davis, Ruth Joanna, Mirandola, Massimo, Hoelscher, Michael, Meyer, Laurence, Laouénan, Cédric, Giannella, Maddalena, Rodríguez-Baño, Jesús, Boffetta, Paolo, Mates, Dana, Malhotra-Kumar, Surbhi, Scipione, Gabriella, Stellmach, Caroline, Rinaldi, Eugenia, Hasenauer, Jan, Tacconelli, Evelina, European Commission, Azzini, Anna Maria, Canziani, Lorenzo Maria, Davis, Ruth Joanna, Mirandola, Massimo, Hoelscher, Michael, Meyer, Laurence, Laouénan, Cédric, Giannella, Maddalena, Rodríguez-Baño, Jesús, Boffetta, Paolo, Mates, Dana, Malhotra-Kumar, Surbhi, Scipione, Gabriella, Stellmach, Caroline, Rinaldi, Eugenia, Hasenauer, Jan, and Tacconelli, Evelina

Abstract

ORCHESTRA (“Connecting European Cohorts to Increase Common and Effective Response To SARS-CoV-2 Pandemic”) is an EU-funded project which aims to help rapidly advance the knowledge related to the prevention of the SARS-CoV-2 infection and the management of COVID-19 and its long-term sequelae. Here, we describe the early results of this project, focusing on the strengths of multiple, international, historical and prospective cohort studies and highlighting those results which are of potential relevance for vaccination strategies, such as the necessity of a vaccine booster dose after a primary vaccination course in hematologic cancer patients and in solid organ transplant recipients to elicit a higher antibody titer, and the protective effect of vaccination on severe COVID-19 clinical manifestation and on the emergence of post-COVID-19 conditions. Valuable data regarding epidemiological variations, risk factors of SARS-CoV-2 infection and its sequelae, and vaccination efficacy in different subpopulations can support further defining public health vaccination policies.

Published
2023

13. Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author

European Commission, Netherlands Organisation for Health Research and Development, Institut National de la Santé et de la Recherche Médicale (France), Ministère des Affaires sociales, de la Santé et des Droits des femmes (France), Gentilotti, Elisa, Górska, Anna, Tami, Adriana, Gusinow, Roy, Mirandola, Massimo, Rodríguez-Baño, Jesús, Palacios-Baena, Zaira Raquel, Rossi, Elisa, Hasenauer, Jan, Lopes-Rafegas, Iris, Righi, Elda, Caroccia, Natascia, Cataudella, Salvatore, Pasquini, Zeno, Osmo, Thomas, Piccolo, Lidia Del, Savoldi, Alessia, Kumar-Singh, Samir, Mazzaferri, Fulvia, Caponcello, Maria Giulia, Boer, Gerolf de, Hara, Gabriel Levy, ORCHESTRA Study Groupt, Nardo, Pasquale De, Malhotra, Surbhi, Canziani, Lorenzo Maria, Ghosn, Jade, Florence, Aline-Marie, Lafhej, Nadhem, van der Gun, Bernardina T. F., Giannella, Maddalena, Laouénan, Cédric, Tacconelli, Evelina, European Commission, Netherlands Organisation for Health Research and Development, Institut National de la Santé et de la Recherche Médicale (France), Ministère des Affaires sociales, de la Santé et des Droits des femmes (France), Gentilotti, Elisa, Górska, Anna, Tami, Adriana, Gusinow, Roy, Mirandola, Massimo, Rodríguez-Baño, Jesús, Palacios-Baena, Zaira Raquel, Rossi, Elisa, Hasenauer, Jan, Lopes-Rafegas, Iris, Righi, Elda, Caroccia, Natascia, Cataudella, Salvatore, Pasquini, Zeno, Osmo, Thomas, Piccolo, Lidia Del, Savoldi, Alessia, Kumar-Singh, Samir, Mazzaferri, Fulvia, Caponcello, Maria Giulia, Boer, Gerolf de, Hara, Gabriel Levy, ORCHESTRA Study Groupt, Nardo, Pasquale De, Malhotra, Surbhi, Canziani, Lorenzo Maria, Ghosn, Jade, Florence, Aline-Marie, Lafhej, Nadhem, van der Gun, Bernardina T. F., Giannella, Maddalena, Laouénan, Cédric, and Tacconelli, Evelina

Abstract

[Background] Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs., [Methods] This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant of Concern (VoC), and physical and mental quality of life (QoL). Outcome of interest was identification of risk and protective factors of PCS by clinical phenotype, setting, severity of disease, treatment, and vaccination status. We used SF-36 questionnaire to assess evolution in QoL index during follow-up and unsupervised machine learning algorithms (principal component analysis, PCA) to explore symptom clusters. Severity of PCS was defined by clinical phenotype and QoL. We also used generalized linear models to analyse the impact of PCS on QoL and associated risk and preventive factors. CT registration number: NCT05097677., [Findings] Among 1796 patients enrolled, 1030 (57%) suffered from at least one symptom at 12-month. PCA identified 4 clinical phenotypes: chronic fatigue-like syndrome (CFs: fatigue, headache and memory loss, 757 patients, 42%), respiratory syndrome (REs: cough and dyspnoea, 502, 23%); chronic pain syndrome (CPs: arthralgia and myalgia, 399, 22%); and neurosensorial syndrome (NSs: alteration in taste and smell, 197, 11%). Determinants of clinical phenotypes were different (all comparisons p < 0.05): being female increased risk of CPs, NSs, and CFs; chronic pulmonary diseases of REs; neurological symptoms at SARS-CoV-2 diagnosis of REs, NSs, and CFs; oxygen therapy of CFs and REs; and gastrointestinal symptoms at SARS-CoV-2 diagnosis of CFs. Early treatment of SARS-CoV-2 infection with monoclonal Ab (all clinical phenotypes), corticosteroids therapy for mild/severe cases (NSs), and SARS-CoV-2 vaccination (CPs) were less likely to be associated to PCS (all comparisons p < 0.05). Highest reduction in QoL was detected in REs and CPs (43.57 and 43.86 vs 57.32 in PCS-negative controls, p < 0.001). Female sex (p < 0.001), gastrointestinal symptoms (p = 0.034) and renal complications (p = 0.002) during the acute infection were likely to increase risk of severe PCS (QoL <50). Vaccination and early treatment with monoclonal Ab reduced the risk of severe PCS (p = 0.01 and p = 0.03, respectively)., [Interpretation] Our study provides new evidence suggesting that PCS can be classified by clinical phenotypes with different impact on QoL, underlying possible different pathogenic mechanisms. We identified factors associated to each clinical phenotype and to severe PCS. These results might help in designing pathogenesis studies and in selecting high-risk patients for inclusion in therapeutic and management clinical trials.

Published
2023

15. Short-Term Adverse Events and Antibody Response to the BNT162b2 SARS-CoV-2 Vaccine in 4156 Health Care Professionals

Author

Azzolini, Elena, primary, Canziani, Lorenzo Maria, additional, Voza, Antonio, additional, Desai, Antonio, additional, Pepys, Jack, additional, De Santis, Maria, additional, Ceribelli, Angela, additional, Pozzi, Chiara, additional, Turato, Massimo, additional, Badalamenti, Salvatore, additional, Germagnoli, Luca, additional, Mantovani, Alberto, additional, Rescigno, Maria, additional, and Selmi, Carlo, additional

Published
2022
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16. Efficacy and safety of baricitinib in 446 patients with rheumatoid arthritis: a real-life multicentre study

Author

Guidelli, Giacomo Maria, primary, Viapiana, Ombretta, additional, Luciano, Nicoletta, additional, De Santis, Maria, additional, Boffini, Nicola, additional, Quartuccio, Luca, additional, Birra, Domenico, additional, Conticini, Edoardo, additional, Chimenti, Maria Sole, additional, Bazzani, Chiara, additional, Bruschi, Eleonora, additional, Riva, Marta, additional, Canziani, Lorenzo Maria, additional, Bianchi, Gerolamo, additional, Pozzi, Maria Rosa, additional, Limonta, Massimiliano, additional, Gorla, Roberto, additional, Perricone, Roberto, additional, Frediani, Bruno, additional, Moscato, Paolo, additional, De Vita, Salvatore, additional, Dagna, Lorenzo, additional, Rossini, Maurizio, additional, and Selmi, Carlo, additional

Published
2021
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18. Antimicrobial Stewardship in COVID-19 Patients: Those Who Sow Will Reap Even through Hard Times.

Author

Sibani M, Canziani LM, Tonolli C, Armellini M, Carrara E, Mazzaferri F, Conti M, Save Working Group, Mazzariol A, Micheletto C, Dalbeni A, Girelli D, and Tacconelli E

Abstract

Background: Since the SARS-CoV-2 pandemic emerged, antimicrobial stewardship (AS) activities need to be diverted into COVID-19 management., Methods: In order to assess the impact of COVID-19 on AS activities, we analyzed changes in antibiotic consumption in moderate-to-severe COVID-19 patients admitted to four units in a tertiary-care hospital across three COVID-19 waves. The AS program was introduced at the hospital in 2018. During the first wave, COVID-19 forced the complete withdrawal of hospital AS activities. In the second wave, antibiotic guidance calibration for COVID-19 patients was implemented in all units, with enhanced stewardship activities in Units 1, 2, and 3 (intervention units). In a controlled before and after study, antimicrobial usage during the three waves of the COVID-19 pandemic was compared to the 12-month prepandemic unit (Unit 4 acted as the control). Antibiotic consumption data were analyzed as the overall consumption, stratified by the World Health Organization AWaRe classification, and expressed as defined-daily-dose (DDD) and days-of-therapy (DOT) per 1000 patient-day (PD)., Results: In the first wave, the overall normalized DOT in units 2-4 significantly exceeded the 2019 level (2019: 587 DOT/1000 PD ± 42.6; Unit 2: 836 ± 77.1; Unit 3: 684 ± 122.3; Unit 4: 872, ± 162.6; p < 0.05). After the introduction of AS activities, consumption decreased in the intervention units to a significantly lower level when compared to 2019 (Unit 1: 498 DOT/1000 PD ± 49; Unit 2: 232 ± 95.7; Unit 3: 382 ± 96.9; p < 0.05). Antimicrobial stewardship activities resulted in a decreased amount of total antibiotic consumption over time and positively affected the watch class and piperacillin-tazobactam use in the involved units., Conclusions: During a pandemic, the implementation of calibrated AS activities represents a sound investment in avoiding inappropriate antibiotic therapy.

Published
2023
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