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531 results on '"Cantore, G."'

1. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.

Author

D'Alessandro, G, Catalano, M, Sciaccaluga, M, Chece, G, Cipriani, R, Rosito, M, Grimaldi, A, Lauro, C, Cantore, G, Santoro, A, Fioretti, B, Franciolini, F, Wulff, H, and Limatola, C

Subjects
Brain, Neuroglia, Astrocytes, Cell Line, Tumor, Animals, Mice, Inbred C57BL, Humans, Mice, Mice, SCID, Glioblastoma, Brain Neoplasms, Neoplasm Invasiveness, Pyrazoles, RNA, Small Interfering, Potassium Channel Blockers, Xenograft Model Antitumor Assays, Cell Movement, Gene Silencing, Male, Intermediate-Conductance Calcium-Activated Potassium Channels, Ca2+-dependent K+ channels, glioblastoma, invasion, astrocytes, microglia, Brain Disorders, Rare Diseases, Cancer, Biotechnology, Brain Cancer, Neurosciences, 2.1 Biological and endogenous factors, Cell Line, Tumor, Inbred C57BL, SCID, RNA, Small Interfering, Oncology and Carcinogenesis, Biochemistry and Cell Biology
Abstract

Glioblastoma multiforme (GBM) is a diffuse brain tumor characterized by high infiltration in the brain parenchyma rendering the tumor difficult to eradicate by neurosurgery. Efforts to identify molecular targets involved in the invasive behavior of GBM suggested ion channel inhibition as a promising therapeutic approach. To determine if the Ca(2+)-dependent K(+) channel KCa3.1 could represent a key element for GBM brain infiltration, human GL-15 cells were xenografted into the brain of SCID mice that were then treated with the specific KCa3.1 blocker TRAM-34 (1-((2-chlorophenyl) (diphenyl)methyl)-1H-pyrazole). After 5 weeks of treatment, immunofluorescence analyses of cerebral slices revealed reduced tumor infiltration and astrogliosis surrounding the tumor, compared with untreated mice. Significant reduction of tumor infiltration was also observed in the brain of mice transplanted with KCa3.1-silenced GL-15 cells, indicating a direct effect of TRAM-34 on GBM-expressed KCa3.1 channels. As KCa3.1 channels are also expressed on microglia, we investigated the effects of TRAM-34 on microglia activation in GL-15 transplanted mice and found a reduction of CD68 staining in treated mice. Similar results were observed in vitro where TRAM-34 reduced both phagocytosis and chemotactic activity of primary microglia exposed to GBM-conditioned medium. Taken together, these results indicate that KCa3.1 activity has an important role in GBM invasiveness in vivo and that its inhibition directly affects glioma cell migration and reduces astrocytosis and microglia activation in response to tumor-released factors. KCa3.1 channel inhibition therefore constitutes a potential novel therapeutic approach to reduce GBM spreading into the surrounding tissue.

Published
2013

9. Evidence-Based Dentistry: What's New?

Author

A. Ballini, S. Capodiferro, M. Toia, S. Cantore, G. Favia, G. De Frenza, F.R. Grassi

Subjects
Medicine
Abstract

The importance of evidence for every branch of medicine in teaching in order to orient the practitioners among the great amount of most actual scientific information's, and to support clinical decisions, is well established in health care, including dentistry. The practice of evidence-based medicine is a process of lifelong, self-directed, problem-based learning which leads to the need for clinically important information about diagnosis, prognosis, therapy and other clinical and health care issues. Nowadays the practice of dentistry is becoming more complex and challenging because of the continually changing in dental materials and equipments, an increasingly litigious society, an increase in the emphasis of continuing professional development, the information explosion and the consumer movement associated with advances on the Internet. The need for reliable information and the electronic revolution have come together to allow the “paradigm shift” towards evidence-based health care. Recent years have seen an increase in the importance of evidence-based dentistry, aiming to reduce to the maximum the gap between clinical research and real world dental practice. Aim of evidence-based practice is the systematic literature review, which synthesizes the best evidences and provides the basis for clinical practice guidelines. These practice guidelines give a brief review of what evidence-based dentistry is and how to use it.

Published
2007

21. Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy

Author

Ragozzino, D., Palma, E., Di Angelatonio, S., Amici, M., Mascia, A., Arcella, A., Giangaspero, F., Cantore, G. Di Gennaro, G., Manfredi, M., Esposito, V. Quarato, P.P., Miledi, R., and Eusebi, F.

Subjects
Epilepsy -- Research, Epilepsy -- Care and treatment, Drug resistance -- Research, Science and technology
Abstract

Pharmacotherapeutic strategies have been difficult to develop for several forms of temporal lobe epilepsy, which are consequently treated by surgical resection. To examine this problem, we have studied the properties of transmitter receptors of tissues removed during surgical treatment. We find that when cell membranes, isolated from the temporal neocortex of patients afflicted with drug-resistant mesial temporal lobe epilepsy (TLE), are injected into frog oocytes they acquire GABA type A receptors (GABAA-receptors) that display a marked rundown during repetitive applications of GABA. In contrast, GABAA-receptor function is stable in oocytes injected with cell membranes isolated from the temporal lobe of TLE patients afflicted with neoplastic, dysgenetic, traumatic, or ischemic temporal lesions (lesional TLE, LTLE). Use-dependent GABAA-receptor rundown is also found in the pyramidal neurons of TLE neocortical slices and is antagonized by BDNF. Pyramidal neurons in cortical slices of a traumatic LTLE patient did not show GABAA-receptor rundown. However, the apparent affinity of GABAA-receptor in oocytes microtransplanted with membranes from all of the epileptic patients studied was smaller than the affinity of receptors transplanted from the nonepileptic brain. We conclude that the use-dependent rundown of neocortical GABAAreceptor represents a TLE-specific dysfunction, whereas the reduced affinity may be a general feature of brains of both TLE and LTLE patients, and we speculate that our findings may help to develop new treatments for TLE and LTLE. human slices | Xenopus oocytes

Published
2005

22. BDNF modulates [GABA.sub.A] receptors microtransplanted from the human epileptic brain to Xenopus oocytes

Author

Palma, E., Torchia, G., Limatola, C., Trettel, F., Arcella, A., Cantore, G., Di Gennaro, G., Manfredi, M., Esposito, V., Quarato, P.P., Miledi, R., and Eusebi, F.

Subjects
Temporal lobe epilepsy -- Research, Temporal lobe epilepsy -- Genetic aspects, Science and technology
Abstract

Cell membranes isolated from brain tissues, obtained surgically from six patients afflicted with drug-resistant temporal lobe epilepsy and from one nonepileptic patient afflicted with a cerebral oligodendroglioma, were injected into frog oocytes. By using this approach, the oocytes acquire human GAB[A.sub.A] receptors, and we have shown previously that the 'epileptic receptors' (receptors transplanted from epileptic brains) display a marked run-down during repetitive applications of GABA. It was found that exposure to the neurotrophin BDNF increased the amplitude of the 'GABA currents' (currents elicited by GABA) generated by the epileptic receptors and decreased their run-down; both events being blocked by K252A, a neurotrophin tyrosine kinase receptor B inhibitor. These effects of BDNF were not mimicked by nerve growth factor. In contrast, the GAB[A.SUB.A] receptors transplanted from the nonepileptic human hippocampal uncus (obtained during surgical resection as part of the nontumoral tissue from the oligodendroglioma margins) or receptors expressed by injecting rat recombinant [alpha]1[beta]2[gamma]2 GAB[A.SUB.A] receptor subunit cDNAs generated GABA currents whose time-course and run-down were not altered by BDNF. Loading the oocytes with the [Ca.sup.2+] chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate-acetoxymethyl ester (BAPTA-AM), or treating them with Rp-8-Br-cAMP, an inhibitor of the cAMP-dependent PKA, did not alter the GABA currents. However, staurosporine (a broad spectrum PK inhibitor), bisindolylmaleimide I (a PKC inhibitor), and U73122 (a phospholipase C inhibitor) blocked the BDNF-induced effects on the epileptic GABA currents. Our results indicate that BDNF potentiates the epileptic GAB[A.SUB.A] currents and antagonizes their use-dependent run-down, thus strengthening GABAergic inhibition, probably by means of activation of tyrosine kinase receptor B receptors and of both PLC and PKC. microtransplantation into Xenopus oocytes | temporal lobe epilepsy

Published
2005

24. Phosphatase inhibitors remove the run-down of [gamma]-aminobutyric acid type A receptors in the human epileptic brain

Author

Palma, E., Ragozzino, D.A., Di Angelantonio, S., Spinelli, G., Trettel, F., Martinez-Torres, A., Torchia, G., Arcella, A., Di Gennaro, G., Quarato, P.P., Esposito, V., Cantore, G., Miledi, R., and Eusebi, F.

Subjects
Temporal lobe epilepsy -- Research, Temporal lobe epilepsy -- Drug use, Science and technology
Abstract

The properties of [gamma]-aminobutyric acid (GABA) type A receptors (GAB[A.sub.A] receptors) microtransplanted from the human epileptic brain to the plasma membrane of Xenopus oocytes were compared with those recorded directly from neurons, or glial cells, in human brains slices. Cell membranes isolated from brain specimens, surgically obtained from six patients afflicted with drug-resistant temporal lobe epilepsy (TLE) were injected into frog oocytes. Within a few hours, these oocytes acquired GAB[A.sub.A] receptors that generated GABA currents with an unusual run-down, which was inhibited by orthovanadate and okadaic acid. In contrast, receptors derived from membranes of a nonepileptic hippocampal uncus, membranes from mouse brain, or recombinant rat [alpha]1[beta]2[gamma]2-GABA receptors exhibited a much less pronounced GABA-current rundown. Moreover, the GAB[A.sub.A] receptors of pyramidal neurons in temporal neocortex slices from the same six epileptic patients exhibited a stronger run-down than the receptors of rat pyramidal neurons. Interestingly, the GAB[A.sub.A] receptors of neighboring glial cells remained substantially stable after repetitive activation. Therefore, the excessive GABA-current run-down observed in the membrane-injected oocytes recapitulates essentially what occurs in neurons, rather than in glial cells. Quantitative RT-PCR analyses from the same TLE neocortex specimens revealed that GAB[A.sub.A]receptor [beta]1, [beta]2, [beta]3, and [gamma]2 subunit mRNAs were significantly overexpressed (8- to 33-fold) compared with control autopsy tissues. Our results suggest that an abnormal GABA-receptor subunit transcription in the TLE brain leads to the expression of run-down-enhanced GAB[A.sub.A] receptors. Blockage of phospbatases stabilizes the TLE GAB[A.sub.A] receptors and strengthens GABAergic inhibition. It may be that this process can be targeted to develop new treatments for intractable epilepsy. temporal lobe epilepsy | microtransplantation into Xenopus oocyte | okadaic acid | [gamma]-aminobutyric acid-current run-down | human tissue slices

Published
2004

29. On application of nonlinear k-[epsilon] models for internal combustion engine flows

Author

Bianchi, G.M., Cantore, G., Parmeggiani, P., and Michelassi, V.

Subjects
Internal combustion engines -- Research, Turbulence -- Research, Engineering and manufacturing industries, Science and technology
Abstract

The linear k-[epsilon] model, in its different formulations, still remains the most widely used turbulence model for the solutions of internal combustion engine (ICE) flows thanks to the use of only two scale-determining transport variables and the simple constitutive relation. This paper discusses the application of nonlinear k-[epsilon] turbulence models for internal combustion engine flows. Motivations to nonlinear eddy viscosity models use arise from the consideration that such models combine the simplicity of linear eddy-viscosity models with the predictive properties of second moment closure. In this research the nonlinear k-[epsilon] models developed by Speziale in quadratic expansion, and Craft et al. in cubic expansion, have been applied to a practical tumble flow. Comparisons between calculated and measured mean velocity components and turbulence intensity were performed for simple flow structure case. The effects of quadratic and cubic formulations on numerical predictions were investigated too, with particular emphasis on anisotropy and influence of streamline curvature on Reynolds stresses.

Published
2002

37. Abstracts

Author

Derlon J. M., Petit-taboué M. C., Dauphin F., Courtheoux P., Chapon F., Creissard P., Darcel F., Houtteville J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go K. G., Kamman R. L., Mooyaart E. L., Heesters M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn U., Fröhlich T., Becker G., Krone A., Schlief R., Schürmann J., Jachimczak P., Hofmann E., Roggendorf W., Roosen K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank G. S., Patterson J., Hadley D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. M., Luxen, A., Brotchi, J., Hildebrand, J., Hausmann, O., Merlo, A., Jerrnann, E., Uirich, J., Chiquet-Ehrismann, R., Müller, J., Mäcke, H., Gratzl, O., Herholz, K., Ghaemi, M., Würker, M., Pietrzyk, U., Heiss, W. -D., Kotitschke, K., Brandl, M., Tonn, J. C., Haase, A., Bogdahn, U., Kotitschke, K., Muigg, S., Felber, S., Aichner, F., Haase, A., Bogdahn, U., Krone A., Becker G., Woydt M., Roggendorf W., Hofmann E., Bogdahn U., Roosen K., Lanfermann, Heinrich, Heindel, Walter, Kugel, Harald, Erneslus, Ralf -Ingo, Röhn, Gabricle, Lackner, Klaus, Metz, R. J., Kennedy, D. N., Pardo, F. S., Kutke, S., Sorensen, A. G., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Rosen, B. R., Caviness, V. S., Mechtler, L. L., Withiam-Lench, S., Shin, K., Klnkel, W. R., Patel, M., Truax, B., Kinkel, P., Shin, K., Mechtler, L., Ricci M., Pantano P., Maleci A., Pierallini S., Di Stefano D., Bozzao L., Cantore G. P., Röhn, Gabriele, Els, T., Schröder, R., Hoehn-Berlage, M., Ernestus, R. -I., Ruda, R., Mocellini, C., Soffietti, R., Campana, M., Ropolo, R., Riva, A., de Filippi, P. G., Schiffer, D., Salgado D., Rodrigues M., Salgado L., Fonseca A. T., Vieira M. R., Bravo Marques J. M., Satoh, H., Uozumi, T., Kiya, K., Kurisu, K., Arita, K., Sumida, M., Ikawa, F., Tzuk-Shina, Tz., Gomori, J. M., Rubinstein, R., Lossos, A., Siegal, T., Vaalburg, W., Paans, A. M. J., Willemsen, A. T. M., van Waarde, A., Pruim, J., Visser, G. M., Go, K. G., Valentini, S., Ting, Y. L. T., De Rose, R., Chidichimo, G., Corricro, G., van Lcycn-Pilgram, Karin, Erncslus, Ralf -Ingo, Klug, Norfried, van Leyen-Pilgram, K., Ernestus, R. -I., Schröder, R., Klug, N., Woydt M., Krone A., Tonn J. C., Becker G., Neumann U., Roggendorf W., Roosen K., Plate, Karl H., Breier, Georg, Millaucr, Birgit, Weich, Herbert A., Ullrich, Axel, Risau, Werner, Roosen N., Chopra R. K., Mikkelsen T., Rosenblum S. D., Yan P. S., Knight R., Windham J., Rosenblum M. L., Schiffer, D., Attanasio, A., Cavalla, P., Chio, A., Giordana, M. T., Migheli, A., Amberger, V., Hensel, T., Schwab, M. E., Cervoni, Luigi, Celli, Paolo, Tarantino, Roberto, Huettner, C., Tonn, J. C., Berweiler, U., Roggendorf, W., Salmon, I., Rorive, S., Rombaut, K., Pirotte, B., Haot, J., Brotchi, J., Kiss, R., Maugard-Louboutin C., Charrier J., Fayet G., Sagan C., Cuillioere P., Ricolleau G., Martin S., Menegalli-Bogeelli D., Lajat Y., Resche F., Molnàr, Péter, Bárdos, Helga, Ádány, Róza, Rogers, J. P., Pilkington, G. J., Pollo, B., Giaccone, G., Allegranza, A., Bugiani, O., Prim, J., Badia, J., Ribas, E., Coello, F., Shezen, E., Lossos, A., Abramsky, O., Siegal, T., Scerrati M., Roselli R., Iacoangeli M., Pompucci A., Rossi G. F., Deeb, Saleh M. Al., Koreich, Osama, Yaqub, Basim, Moutaery, Khalaf R. Al., Giordana, M. T., Cavalla, P., Chio, A., Marino, S., Vigliani, M. C., Schiffer, D., Deburghgraeve, V., Darcel, F., Gedouin, D., Hassel, M. Ben, Guegan, Y., Jeremic, B., Grujicic, D., Antunovic, V., Matovic, M., Shibamoto, Y., Kallio, Merja, Huhmar, Helena, Kudoh, Ch., Detta, A., Sugiura, K., Hitchcock, E. R., Mastrostefano, R., Di Russo, R., Cipriani§, M., Occhipinti, E. M., Conti, E. M. S., Clowegeser A., Ortler M., Seiwald M., Kostron H., Rajan B., Ross G., Lim C., Ashlcy S., Goode D., Traish D., Brada M., Sanden, G. A. C. vd, Schouten, L. J., Coebergh, J. W. W., Razenberg, P. P. A., Twijnstra, A., Snilders-Keilholz, A., Voormolen, J. H. C., Hermans, J., Leer, J. W. H., Taillandier, L., Baylac, F., Dcbouvcrie, M., Anxionnal, R., Bracard, S., Vignand, J. M., Duprcz, A., Weber, M., Winking, M., Böker, D. K., Simmet, T., Rothbart, David, Strugar, John, Balledux, Jeroen, Criscuolo, Gregory R., Jachimczak, Piotr, Blesch, Armin, Heβdörfer, Birgit, Bogdahn, Ulrich, Ernestus, Ralf -Ingo, Schröder, Roland, Klug, Norfrid, Krouwer, H. G. J., Duinen, S. G. v., Algra, A., Zentner, J., Wolf, H. K., Ostertun, B., Hufnagel, A., Campos, M. G., Solymosi, L., Schramm, J., Newlands, E. S., O'Reilly, S. M., Brampton, M., Soffietti, R., Chio, A., Mocellini, C., Ruda, R., Vigliani, M. C., Schiffer, D., Sciolla, R., Seliak, D., Henriksson, R., Bergenheim, A. T., Björk, P., Gunnarsson, P. -O., Hariz, Ml., Grant, R., Collie, D., Gregor A., Ebmeier K. P., Jarvis G., Lander F., Cull A., Sellar R., Brada, M., Thomas, C., Elyan, S., Hines, F., Ashley, S., Stenning, S., Bernstein J. J., Goldberg W. J., Roelcke U., Von Ammon K., Hausmann O., Radu E. W., Kaech D., Leenders K. L., Fitzek, II, M. M., Aronen J. Efird, Hochberg, F., Gruber, M., Schmidt, E., Rosen, B., Flschman, A., Pardo, P., Afra U. M. U., Sipos, L., Slouik, F., Boiardi A., Salmaggi A., Pozzi A., Farinotti L., Fariselli L., Silvani A., Brandes, A., Scelzi, E., Rigon, A., Zampieri, P., Pignataro, M., Amanzo, P. D'., Amista, P., Rotilio, A., Fiorentino, M. V., Thomas, R., Brazil, L., O'Connor, A. M., Ashley, S., Brada, M., Salvati, Maurizio, Cervoni, Luigi, Puzzilli, Fabrizio, Cervoni, Luigi, Salvati, Maurizio, Raguso, Michele, Cruickshank G. S., Duckworth R., Rumpling R., Rottuci M., Fariselli L., Boiardi A., Broggi G., Plrint, N. G., Sabattini, E., Manetto, V., Gambacorta, H., Poggi, S., Pileri, S., Ferracini, R., Grant, R., Plev D. V., Hopf N. J., Knosp E., Bohl J., Perncczky A., Kiss, R., Salmon, I., Catnby, I., Dewitte, O., Brotchi, J., Pasteels, J. L., Camby, I., Salmon, I., Darro, F., Danguy, A., Brotchi, J., Pasteels, J. L., Kiss, R., Kiu, M. C., Lai, G. M., Yang, T. S., Ng, K. T., Chen, J. S., Chang, C. N., Leung, W. M., Ho, Y. S., Rychter, M. Deblec, Klimek, A., Liberski, P. P., Karpinaka, A., Krauseneck P., Schöffel V., Müller B., Kreth, F. W., Faist, M., Warnke, P. C., Ostertag, C. B., Nielen, K. M. B. v., Visscr, M. C., Lebrun C., Lonjon M., Desjardin T., Michiels J. F., Chanalet Sa. Lagrange J. L., Roche J. L., Chatel M., Mastronardi L., Puzzilli F., Osman Farah J., Lunardi P., Matsutani, M., Ushio, Y., Takakura, K., Menten, Johan, Hamers, Han, Ribot, Jacques, Dom, René, Tcepen, Hans, Müller B., Weidner N., Krauseneck P., Naujocks, G., van Roost, D., Wiestler, O. D., Kuncz, A., Nieder, C., Setzel-Sesterhein, M., Niewald, M., Schnabel, I., O'Neill, K. S., Kitchen, N. D., Wilkins, P. R., Marsh, H. T., Pierce, E., Doshi, R., Deane, R., Previtali, S., Quattrini, A., Nemni, R., Ducati, A., Wrabetz, L., Canal, N., Punt, C. J. A., Stamatakis, L., Giroux, B., Rutten, E., Quigley, Matthew R., Beth Sargent P. A. -C., Flores, Nicholas, Simon, Sheryl, Maroon, Joseph C., Quigley, Matthew R., Beth Sargent P. A. -C., Flores, Nicholas, Maroon, Joseph C., Rocca A. A., Gervasoni C., Castagna A., Picozzi P., Giugni E., Rocca A. A., Tonnarelli G. P., Ducati A., Mangili F., Truci G., Canal N., Giovanelli M., Roelcke U., Von Ammon K., Radu E. W., Leenders K. L., Sachsenheimer, W., Bimmler, T., Seiwald M., Eiter H. Rhomberg W., Ortler M., Obwegesser A., Kostron H., Steilen H., Henn W., Moringlane J. R., Kolles H., Feiden W., Zang K. D., Sleudel W. I., Steinbrecher, Andreas, Schabet, Martin, Heb, Clemens, Bamberg, Michael, Dichgans, Johannes, Stragliotto, G., Delattre, J. Y., Poisson, M., Zampieri, P., Brandes, A., Rigon, A., Tosatto, L., D'Amanzo, P., Menicucci, N., Rotilio, A., Mingrino, S., Steudel, W. I., Feld, R., Henn, W., Zang, K. D., Maire, J. Ph., Caudry, M., Guerin, J., Celerier, D., Salem, N., Demeaux, H., Fahregat, J. F., Kusak, M. E., Bucno, A., Albisua, J., Jerez, P., Sarasa, J. L., Garefa, R., de Campos, J. M., Kusak, M. E., de Campos, J. M., Bueno, A., García-Delgado, R., Sarasa, J. L., García-Sola, R., Lantsov A. A., Shustova T. I., Lcnartz, D., Wellenreuther, R., von Deirnling, A., Köning, W., Menzel, J., Scarpa, S., Manna, A., Reale, M. G., Oppido, P. A., Carapella, C. M., Frati, L., Valery, C. A., Ichen, M., Foncin, J. P., Soubrane, C., Khayat, D., Philippon, J., Vaz, R., Cruz, C., Weis S., Protopapa D., März R., Winkler P. A., Reulen H. J., Bise K., Beuls E., Berg J., Deinsberger, W., Böker, D. K., Samii, M., Caudry, M., Darrouzet, V., Guérin, J., Trouette, R., Causse, N., Bébéar, J. P., Parker, F., Vallee, J. N., Carlier, R., Zerah, M., Lacroix-Jousselin, C., Piepmeier, Joseph M., Kveton, John, Czibulka, Agnes, Tigliev G. S., Chernov M. P., Maslova L. N., Valdueza, José M., Jänisch, Werner, Bock, Alexander, Harms, Lutz, Bessell, E. M., Graus, F., Punt, J., Firth, J., Hope, T., Koriech, Osama, Al Deeb, Saleh, Al Moutaery, Khalaf, Yaqub, B., Silvani A., Salmaggi A., Pozzi A., Franzini A., Boiardi A., Goldbrunner, R., Warmuth-Metz, M., Paulus, W., Tonn, J. -Ch., Roosen, K., Strik I. I., Müller B., Markert C., Pflughaupt K. -W., Krauseneck P., O'Neill, B. P., Dinapoli, R. P., Voges, J., Sturm, V., Deuß, U., Traud, C., Treuer, H., Lehrke, R., Kim, D. G., Müller, R. P., Alexandrov Yu. S., Moutaery, K., Aabed, M., Koreich, O., Ross, G. M., Rajan, B., Traish, D., Ashley, S., Ford, D., Brada, M., Schmeets, I. L. O., Jager, J. J., Pannebakker, M. A. G., de Jong, J. M. A., van Lindert, E., Knosp, E., Kitz, K., Blond, S., Dubois, F., Assaker, R., Baranzelli, M. C., Sleiman, M., Pruvo, J. P., Coche-Dequeant, B., Matsutani M., Takakura K., Sano K., PetriČ-Grabnar, G., Jereb, B., Župančič, N., Koršič, M., Rainov N. G., Burkert W., Ushio, Yukitaka, Kochi, Masato, Itoyama, Youichi, de Campos, J. M., Kusak, M. E., Sarasa, J. L., García, R., Bueno, A., Ferrando, L., Hoang-Xuan, K., Sanson, M., Merel, P., Delattre, J. Y., Poisson, M., Delattre, O., Thomas, G., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Thomas, G., Haritz, D., Obersen, B., Grochulla, F., Gabel, D., Haselsberger K., Radner H., Pendl G., Brada, M., Laing, R. W., Warrington, A. P., Nowak, P. J. C. M., Kolkman-Deurloo, I. K. K., Visser, A. G., Berge, Hv. d., Niël, C. G. J. H., Levendag, P. 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H., Pfeiffer, G., Netzer, J., Hansen, Ch., Eggers, Ch., Hagel Ch., Kunze, K., Verschuuren, Jan J., Rosenblum, Marc K., Lieberman, Frank S., Posner, Jerome B., and Dalmau, Josep

Published
1994
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45. Optimization of injection law for direct injection diesel engine

Author

Feola, M., Pelloni, P., Cantore, G., Bella, G., Casoli, P., and Toderi, G.

Subjects
Diesel motor -- Fuel and fuel systems, Diesel motor exhaust gas -- Research, Engineering and manufacturing industries, Science and technology
Abstract

This paper describes how different timing and shape of the injection law can influence pollutant emission of a direct injection diesel engine. The study was carried out making use of a 'multizone' thermodynamic model as regards the closed valve phase, and a 'filling-emptying' one as regards the open valve phase. After being calibrated by comparison with experimental data, the abovementioned model was used for injection law optimization as regards minimum pollutant concentration ([NO.sub.x] and soot) in the exhaust gases with the smallest engine performance reduction possible.

Published
1992

48. Unruptured Aneurysms Italian Study (UAIS) background and method

Author

Versari, P. b, Tartara, F. b, Scerrati, M. c, Caroselli, G. c, Pasquini, U. c, Ciappetta, P. d, Vailati, G. d, Occhiogrosso, M. d, Biroli, F. e, Bonaldi, G. e, Calbucci, F. f, Andreoli, A. f, Leopardi, M. f, Raff, L. f, Bollati, A. g, Gasparotti, R. g, Martellotto, N. h, Distefano, G. h, Pinna, G. i, Francaviglia, N. j, Ventura, F. k, Orazio, G. k, Cristaudo, C. k, Consoli, V. l, Nicoletti, G. l, Albanese, V. m, Ceccotti, C. n, Frattarelli, M. o, Servadei, F. o, Cremonini, A. M. o, Taborelli, A. p, Corriero, G. q, Galli, G. r, Morandini, A. r, Medina, M. s, Padovani, R. t, Farneti, M. t, Ghadirpour, R. t, DiLorenzo, N. u, Mennonna, P. v, Ammannati, F. v, Mangiafico, S. v, Celerini, M. v, Paoli, L. v, Andrioli, G. w, Zerbi, D. w, Spaziante, R. x, Pau, A. x, Stefani, F. x, Zona, G. L. x, Castellan, L. x, Cantore, G. y, Innocenzi, G. y, Galzio, R. z, Ricci, A. z, Montinaro, A. aa, Cantisani, P. aa, Arena, O. ab, Tonnarelli, G. P. ac, Gagliardi, R. ad, Benvenuti, L. ad, Tomasello, F. ae, Paterniti, S. ae, Trincia, G. af, Conti, C. af, Broggi, G. ag, Giombini, S. ag, Solero, C. L. ag, Marras, C. ag, Todaro, Ciceri, E. ag, Fornari, M. ah, DeSantis, A. ah, Cardia, Ortolina, Rodriguez, R. ai, Gaetani, P. ai, Collice, M. aj, D'Aliberti, G. aj, Talamonti, G. aaj, LaCamera, A. aj, Boccardi, E. aj, Villani, R. ak, Gaini, S. ak, Miserocchi, G. ak, Branca, V. ak, Giovanelli, M. al, Cenzato, Scotti, G. al, Merli, A. am, Piazza, P. am, Sganzerla, E. an, Profeta, G. ao, Daniele, B. ao, Monsignore, R. ao, Cioffi, F. ap, Rotondo, M. ap, Natale, DeDivitiis, E. aq, F. aq, Franco, A. ar, Apolito, R. ar, Delehaye, L. ar, Sossio, C. as, Bellotti, C. at, Car, P. G. at, Benvenuto, F. at, Scienza, R. au, Berlucchi, S. au, Pavesi, G. au, Fiore, D. au, LaSeta, F. av, Filizzolo, F. aw, Fiumara, E. aw, Tumbiolo, S. aw, Benericetti, E. ax, Sacchelli, A. ax, Arienta, C. ay, Zappoli, F. ay, Buoncristiani, P. az, Buonaguidi, R. ba, Bianchini, E. ba, Boccardo, M. bb, Valsania, V. bb, Bruzzone, L. bb, Cantini, L. R. bc, Marconi, F. bc, Parenti, G. F. bd, Liberti, G. bd, Severino, P. be, Delitala, A. bf, Cotroneo, E. bf, Gazzeri, G. bg, Fiume, D. bg, Esposito, S. bh, Agrillo, U. bi, Sidoti, C. bi, Maira, G. bj, Vignati, A. bj, Marchese, E. bj, Delfini, R. bk, Guidetti, G. bk, Bufatti, P. bl, Strabella, G. bm, D'Angelo, V. bn, Monte, Florio, F. bn, Olivieri, G. bo, Palma, L. bp, Serchi, E. bp, Fontana, R. bq, Resta, M. br, Faccani, G. bs, Musso, C. bs, Ducati, A. bt, Bradac, G. B. bt, Longatti, P. bu, Tacconi, L. bv, Skrap, M. bw, Nicassio, N. bw, Graziussi, G. bx, Migliaccio, N. bx, Puglisi, A. bx, Tomei, G. by, Bonfanti, N. by, Tabano, A. by, Bricolo, A. bz, Pasqualin, Beltramello, Colombo, F. ca, Causin, Perini, S. ca, MAIURI, FRANCESCO, BRIGANTI, FRANCESCO, Versari, P. b, Tartara, F. b, Scerrati, M. c, Caroselli, G. c, Pasquini, U. c, Ciappetta, P. d, Vailati, G. d, Occhiogrosso, M. d, Biroli, F. e, Bonaldi, G. e, Calbucci, F. f, Andreoli, A. f, Leopardi, M. f, Raff, L. f, Bollati, A. g, Gasparotti, R. g, Martellotto, N. h, Distefano, G. h, Pinna, G. i, Francaviglia, N. j, Ventura, F. k, Orazio, G. k, Cristaudo, C. k, Consoli, V. l, Nicoletti, G. l, Albanese, V. m, Ceccotti, C. n, Frattarelli, M. o, Servadei, F. o, Cremonini, A. M. o, Taborelli, A. p, Corriero, G. q, Galli, G. r, Morandini, A. r, Medina, M., Padovani, R. t, Farneti, M. t, Ghadirpour, R. t, Dilorenzo, N. u, Mennonna, P. v, Ammannati, F. v, Mangiafico, S. v, Celerini, M. v, Paoli, L. v, Andrioli, G. w, Zerbi, D. w, Spaziante, R. x, Pau, A. x, Stefani, F. x, Zona, G. L. x, Castellan, L. x, Cantore, G. y, Innocenzi, G. y, Galzio, R. z, Ricci, A. z, Montinaro, A., Aa, Cantisani, P., Aa, Arena, O., Ab, Tonnarelli, G. P., Ac, Gagliardi, R., Ad, Benvenuti, L., Ad, Tomasello, F., Ae, Paterniti, S., Ae, Trincia, G., Af, Conti, C., Af, Broggi, G., Ag, Giombini, S., Ag, Solero, C. L., Ag, Marras, C., Ag, Todaro, Ciceri, E., Ag, Fornari, M., Ah, Desantis, A., Ah, Cardia, Ortolina, Rodriguez, R., Ai, Gaetani, P., Ai, Collice, M., Aj, D'Aliberti, G., Aj, Talamonti, G., Aaj, Lacamera, A., Aj, Boccardi, E., Aj, Villani, R., Ak, Gaini, S., Ak, Miserocchi, G., Ak, Branca, V., Ak, Giovanelli, M., Al, Cenzato, Scotti, G., Al, Merli, A., Am, Piazza, P., Am, Sganzerla, E., An, Profeta, G., Ao, Daniele, B., Ao, Monsignore, R., Ao, Cioffi, F., Ap, Rotondo, M., Ap, Natale, Dedivitiis, E., Aq, Maiuri, Francesco, F., Aq, Briganti, Francesco, Franco, A., Ar, Apolito, R., Ar, Delehaye, L., Ar, Sossio, C., A, Bellotti, C., At, Car, P. G., At, Benvenuto, F., At, Scienza, R., Au, Berlucchi, S., Au, Pavesi, G., Au, Fiore, D., Au, Laseta, F., Av, Filizzolo, F., Aw, Fiumara, E., Aw, Tumbiolo, S., Aw, Benericetti, E., Ax, Sacchelli, A., Ax, Arienta, C., Ay, Zappoli, F., Ay, Buoncristiani, P., Az, Buonaguidi, R., Ba, Bianchini, E., Ba, Boccardo, M., Bb, Valsania, V., Bb, Bruzzone, L., Bb, Cantini, L. R., Bc, Marconi, F., Bc, Parenti, G. F., Bd, Liberti, G., Bd, Severino, P., Be, Delitala, A., Bf, Cotroneo, E., Bf, Gazzeri, G., Bg, Fiume, D., Bg, Esposito, S., Bh, Agrillo, U., Bi, Sidoti, C., Bi, Maira, G., Bj, Vignati, A., Bj, Marchese, E., Bj, Delfini, R., Bk, Guidetti, G., Bk, Bufatti, P., Bl, Strabella, G., Bm, D'Angelo, V., Bn, Monte, Florio, F., Bn, Olivieri, G., Bo, Palma, L., Bp, Serchi, E., Bp, Fontana, R., Bq, Resta, M., Br, Faccani, G., B, Musso, C., B, Ducati, A., Bt, Bradac, G. B., Bt, Longatti, P., Bu, Tacconi, L., Bv, Skrap, M., Bw, Nicassio, N., Bw, Graziussi, G., Bx, Migliaccio, N., Bx, Puglisi, A., Bx, Tomei, G., By, Bonfanti, N., By, Tabano, A., By, Bricolo, A., Bz, Pasqualin, Beltramello, Colombo, F., Ca, Causin, Perini, and S., Ca

Subjects
Aneurysm
Published
2006

Catalog

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