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3. Sex-specific dietary patterns and their association with metabolic syndrome: Insights from a cross-sectional analysis

Author

Popescu, Mónica Lavinia, Rubín-García, María, Álvarez-Álvarez, Laura, Toledo, Estefanía, Corella, Dolores, Salas-Salvadó, Jordi, Pérez-Vega, Karla Alejandra, Martínez, J Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Cano-Ibáñez, Naomi, Tur, Josep A., Naveiro, Roi, Pintó, Xavier, Delgado-Rodríguez, Miguel, Ortiz-Ramos, María, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Vázquez-Ruiz, Zenaida, Babio, Nancy, Sorlí, Jose V., Castañer, Olga, García-Rios, Antonio, González-Palacios, Sandra, Zulet, María, Konieczna, Jadwiga, Casas, Rosa, Masso-Guijarro, Paloma, Tojal-Sierra, Lucas, Gómez-Pérez, Ana M., Cenoz-Osinaga, Juan Carlos, Valverde, Irene, Fernández-Carrión, Rebeca, Schröder, Helmut, Arenas Larriva, Antonio P., Torres-Collado, Laura, García-Arellano, Ana, Palau-Galindo, Antoni, Fitó, Montserrat, Martín-Sánchez, Vicente, and Fernández-Villa, Tania

Published
2024
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4. Long-term association between water intake and kidney function in a population at high cardiovascular risk

Author

Paz-Graniel, Indira, Valle-Hita, Cristina, Babio, Nancy, Serra-Majem, Lluís, Vioque, Jesus, Zomeño, María Dolores, Corella, Dolores, Pintó, Xavier, Cano-Ibáñez, Naomi, Tur, Josep A., Cuadrado-Soto, Esther, Martínez, J.A., Díaz-López, Andrés, Torres-Collado, Laura, Goday, Albert, Fernández-Carrión, Rebeca, Nissenshon, Mariela, Riera-Mestre, Antoni, Garrido-Garrido, Eva, Bouzas, Cristina, Abete, Itziar, Daimiel, Lidia, Cornejo-Pareja, Isabel, Vázquez-Ruiz, Zenaida, Khoury, Nadine, Pérez-Vega, Karla Alejandra, and Salas-Salvadó, Jordi

Published
2024
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6. Effect of a nutritional intervention based on an energy-reduced Mediterranean diet on environmental impact

Author

Álvarez-Álvarez, Laura, Rubín-García, María, Vitelli-Storelli, Facundo, García, Silvia, Bouzas, Cristina, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Malcampo, Mireia, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, García Fernández, Camino, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, García-Arellano, Ana, Martínez, María Ángeles, Sorlí, José V., Zomeño, María Dolores, García-Rios, Antonio, González-Palacios, Sandra, Monserrat-Mesquida, Margalida, Abete, Itziar, Colom Fernández, Antoni, Casas, Rosa, Cano Ibáñez, Naomi, Ugarriza, Lucía, Bernal-López, M. Rosa, Bes-Rastrollo, Maira, Paz-Graniel, Indira, Asensio, Eva M., Fitó, Montse, Arenas Larriva, Antonio P., Oncina-Cánovas, Alejandro, Vázquez, Zenaida, Fernández de la Puente, María, Pérez-Vega, Alejandra, Tur, Josep A., and Martín-Sánchez, Vicente

Published
2024
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7. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Author

Shyam, Sangeetha, García-Gavilán, Jesús Francisco, Paz-Graniel, Indira, Gaforio, José J., Martínez-González, Miguel Ángel, Corella, Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sánchez, Vicente Martín, Pintó, Xavier, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Fernandez-Aranda, Fernando, Nishi, Stephanie K., Garcia-Regata, Oscar, Toledo, Estefania, Asensio, Eva M., Castañer, Olga, Garcia-Rios, Antonio, Torres-Collado, Laura, Gómez-Gracia, Enrique, Zulet, M. Angeles, Ruiz, Nuria Goñi, Casas, Rosa, Cano-Ibáñez, Naomi, Tojal-Sierra, Lucas, Gómez-Perez, A. M., Sorlí, Jose V., Cinza-Sanjurjo, Sergio, Martín-Peláez, Sandra, Peña-Orihuela, Patricia J., Oncina-Canovas, Alejandro, Perez-Araluce, Rafael, Zomeño, María Dolores, Chaplin, Alice, Delgado-Rodríguez, Miguel, Babio, Nancy, Fitó, Montserrat, and Salas-Salvadó, Jordi

Published
2023
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8. Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study

Author

Nishi, Stephanie K., Babio, Nancy, Paz-Graniel, Indira, Serra-Majem, Lluís, Vioque, Jesús, Fitó, Montserrat, Corella, Dolores, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Diez-Ricote, Laura, Martinez, J. Alfredo, Gómez-Martínez, Carlos, González-Botella, Andrés, Castañer, Olga, Alvarez-Sala, Andrea, Montesdeoca-Mendoza, Cristina, Fanlo-Maresma, Marta, Cano-Ibáñez, Naomi, Bouzas, Cristina, Daimiel, Lidia, Zulet, María Ángeles, Sievenpiper, John L., Rodriguez, Kelly L., Vázquez-Ruiz, Zenaida, and Salas-Salvadó, Jordi

Published
2023
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9. Ultra-processed foods consumption as a promoting factor of greenhouse gas emissions, water, energy, and land use: A longitudinal assessment

Author

García, Silvia, Pastor, Rosario, Monserrat-Mesquida, Margalida, Álvarez-Álvarez, Laura, Rubín-García, María, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, J. Alfredo, Tojal-Sierra, Lucas, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José Manuel, Serra-Majem, Lluís, Cano-Ibañez, Naomi, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Buil-Cosiales, Pilar, Martínez-Rodríguez, María Ángeles, Coltell, Oscar, Castañer, Olga, Garcia-Rios, Antonio, Barceló, Concepción, Gómez-Gracia, Enrique, Zulet, Maria Ángeles, Konieczna, Jadwiga, Casas, Rosa, Massó-Guijarro, Paloma, Goicolea-Güemez, Leire, Bernal-López, María Rosa, Bes-Rastrollo, Maira, Shyam, Sangeetha, González, José I., Zomeño, María Dolores, Peña-Orihuela, Patricia J., González-Palacios, Sandra, Toledo, Estefanía, Khoury, Nadine, Perez, Karla Alejandra, Martín-Sánchez, Vicente, Tur, Josep A., and Bouzas, Cristina

Published
2023
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10. Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study

Author

Ni, Jiaqi, Nishi, Stephanie K., Babio, Nancy, Ros, Emilio, Basterra-Gortari, F Javier, Corella, Dolores, O, Castañer, Martínez, J Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José Manuel, Serra-Majem, Lluís, Cano-Ibáñez, Naomi, Tur, Josep A., Fernández-García, José Manuel, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández-Aranda, Fernando, Ruiz-Canela, Miguel, Mestres Solà, Cristina, Portolés, Olga, Sala-Vila, Aleix, Garcia-Rios, Antonio, Compañ-Gabucio, Laura María, Gómez-Gracia, Enrique, Zulet, M Angeles, Chaplin, Alice, Casas, Rosa, Martínez-Diz, Silvia, Tojal-Sierra, Lucas, Gómez-Pérez, Ana María, Toledo, Estefanía, Rios, Santiago, Ortega-Azorín, Carolina, de la Torre, Rafael, Peña-Orihuela, Patricia J., Garcia-de la Hera, Manuela, Sayón-Orea, Carmen, Malcampo, Mireia, and Salas-Salvadó, Jordi

Published
2023
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11. Increased ultra-processed food consumption is associated with worsening of cardiometabolic risk factors in adults with metabolic syndrome: Longitudinal analysis from a randomized trial

Author

González-Palacios, Sandra, Oncina-Cánovas, Alejandro, García-de-la-Hera, Manuela, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Cano-Ibañez, Naomi, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Bes-Rastrollo, Maira, Atzeni, Alessandro, Sorli, Jose V., Zomeño, M. Dolors, Peña-Orihuela, Patricia J., Compañ-Gabucio, Laura M., Barón-López, Francisco J., Zulet, María Ángeles, Konieczna, Jadwiga, Casas, Rosa M., Garrido-Garrido, Eva M., Tojal-Sierra, Lucas, Gomez-Perez, Ana M., Ruiz-Canela, Miguel, Palau, Antoni, Saiz, Carmen, Pérez-Vega, Karla A., Garcia-Rios, Antonio, Torres-Collado, Laura, Basterra-Gortari, Javier, Garcidueñas-Fimbres, Tany E., Malcampo, Mireia, and Vioque, Jesús

Published
2023
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14. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Author

Valle-Hita, Cristina, Díaz-López, Andrés, Becerra-Tomás, Nerea, Martínez-González, Miguel A., García, Verónica Ruiz, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Cano-Ibáñez, Naomi, Tur, Josep A., Rubín-García, María, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Fontao, Sebastian Mas, Daimiel, Lidia, Ros, Emilio, Toledo, Estefania, Sorlí, José V., Roca, C., Abete, Iztiar, Moreno-Rodriguez, Anai, Crespo-Oliva, Edelys, Candela-García, Inmaculada, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Fernandez-Garcia, Jose Carlos, Santos-Lozano, José Manuel, Diez-Espino, Javier, Ortega-Azorín, Carolina, Comas, M., Zulet, M. Angeles, Sorto-Sanchez, Carolina, Ruiz-Canela, Miguel, Fitó, Montse, Salas-Salvadó, Jordi, and Babio, Nancy

Published
2022
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15. Long-term effect of a dietary intervention with two-healthy dietary approaches on food intake and nutrient density in coronary patients: results from the CORDIOPREV trial

Author

Cano-Ibáñez, Naomi, Quintana-Navarro, Gracia M., Alcala-Diaz, Juan F., Rangel-Zuñiga, Oriol A., Camargo, Antonio, Yubero-Serrano, Elena M., Perez-Corral, Isabel, Arenas-de Larriva, Antonio P., Garcia-Rios, Antonio, Perez-Martinez, Pablo, Delgado-Lista, Javier, and Lopez-Miranda, Jose

Published
2022
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16. Correction to: Long‑term effect of a dietary intervention with two‑healthy dietary approaches on food intake and nutrient density in coronary patients: results from the CORDIOPREV trial

Author

Cano-Ibáñez, Naomi, Quintana-Navarro, Gracia M., Alcala-Diaz, Juan F., Rangel-Zuñiga, Oriol A., Camargo, Antonio, Yubero-Serrano, Elena M., Perez-Corral, Isabel, Arenas-de Larriva, Antonio P., Garcia-Rios, Antonio, Perez-Martinez, Pablo, Delgado-Lista, Javier, and Lopez-Miranda, Jose

Published
2022
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17. Prevalence of obstetric violence in high‐income countries: A systematic review of mixed studies and meta‐analysis of quantitative studies.

Author

Fraser, Laura Katrina, Cano‐Ibáñez, Naomi, Amezcua‐Prieto, Carmen, Khan, Khalid Saeed, Lamont, Ronald F., and Jørgensen, Jan Stener

Subjects
*SECOND stage of labor (Obstetrics), *FEAR of childbirth, *RANDOM effects model, *WOMEN'S rights, *CINAHL database
Abstract

Introduction: Obstetric violence, or mistreatment of women in obstetric care, can have severe consequences such as fear of future childbirth, post‐traumatic stress disorder, and depression. Material and Methods: The primary objective was to estimate the prevalence of obstetric violence in high‐income countries. The secondary objective was to extract the main domains of obstetric violence perceived by women from qualitative studies. Following prospective registration (PROSPERO CRD42023468570), PubMed, Web of Science, Scopus, CINAHL, Embase, and Cochrane Library were searched with no restrictions. Included studies were cross‐sectional, cohort, mixed methods, and qualitative studies based on populations from high‐income countries. The review was conducted by two independent reviewers. Risk of bias was assessed. Rates of obstetric violence were pooled using random effects model, computing 95% confidence intervals (CI) and assessing heterogeneity using I2 statistic. Funnel plots and Egger's test were used to detect potential reporting biases and small‐study effects. Results: Of the 1821 records screened, 25 studies were included: 14 quantitative and 2 mixed methods studies, comprising 60 987 women, and 9 qualitative studies were included, comprising an additional 4356 women. 81.25% of quantitative studies, including the quantitative component of the mixed methods studies, were considered satisfactory or better regarding risk of bias. The prevalence of obstetric violence was overall 45.3% (95% CI 27.5–63.0; I2 = 100.0%). The prevalence of specific forms of mistreatment was also estimated. Lack of access to analgesia was 17.3% (95% CI 6.9–27.7; I2 = 99.7%). Ignored requests for help was 19.2% (95% CI 11.7–26.6; I2 = 99.0%). Shouting and scolding 19.7% (95% CI 13.0–26.4; I2 = 98.7%). The use of fundal pressure during the second stage of labor (Kristeller maneuver) was 30.3% (95% CI 22.1–38.5; I2 = 97.6%). There was no funnel asymmetry. Lack of information and/or consent were the most frequent domains extracted from the qualitative articles and the qualitative component of the mixed methods studies. Conclusions: The results demonstrate that obstetric violence is a prevalent problem that women in high‐income countries experience. Lack of information and/or consent were the domains most frequently described in the qualitative studies and the qualitative component of the mixed methods studies. [ABSTRACT FROM AUTHOR]

Published
2025
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25. Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study

Author

Julibert, Alicia, del Mar Bibiloni, Maria, Gallardo-Alfaro, Laura, Abbate, Manuela, Martínez-González, Miguel Á, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montse, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluís, Cano-Ibañez, Naomi, Martín-Sánchez, Vicente, Pintó, Xavier, Gaforio, José J, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Becerra-Tomás, Nerea, Gimenez-Alba, Ignacio M, Castañer, Olga, Abete, Itziar, Tojal-Sierra, Lucas, Pérez-López, Jéssica, Notario-Barandiaran, Leyre, Colom, Antoni, Garcia-Rios, Antonio, Castro-Barquero, Sara, Bernal, Rosa, Santos-Lozano, José M, Fernández-Lázaro, Cesar I, Hernández-Alonso, Pablo, Saiz, Carmen, Zomeño, Maria D, Zulet, Maria A, Belló-Mora, Maria C, Basterra-Gortari, Javier, Canudas, Silvia, Goday, Albert, and Tur, Josep A

Published
2020
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26. Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk

Author

Sánchez-Quesada, Cristina, Toledo, Estefanía, González-Mata, Guadalupe, Ramos-Ballesta, Maria Isabel, Peis, José Ignacio, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Cano-Ibáñez, Naomi, Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Hernández-Alonso, Pablo, Barragan, Rocío, Muñoz-Martínez, Julia, López, Meritxell, González-Palacios, Sandra, Vaquero-Luna, Jessica, Crespo-Oliva, Edelys, Zulet, M. Angeles, Díaz-González, Vanessa, Casas, Rosa, Fernandez-Garcia, José Carlos, Santos-Lozano, José Manuel, Galera, Ana, Ripoll-Vera, Tomás, Buil-Cosiales, Pilar, Canudas, Silvia, Martinez-Lacruz, Raul, Pérez-Vega, Karla-Alejandra, Rios, Ángel, Lloret-Macián, Rosario, Moreno-Rodriguez, Anai, Ruiz-Canela, Miguel, Babio, Nancy, Zomeño Fajardo, Maria Dolores, and Gaforio, José J.

Published
2020
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28. Diet quality and nutrient density in subjects with metabolic syndrome: Influence of socioeconomic status and lifestyle factors. A cross-sectional assessment in the PREDIMED-Plus study

Author

Cano-Ibáñez, Naomi, Gea, Alfredo, Ruiz-Canela, Miguel, Corella, Dolores, Salas-Salvadó, Jordi, Schröder, Helmut, Navarrete-Muñoz, Eva M<ce:sup loc='post">a</ce:sup>., Romaguera, Dora, Martínez, J. Alfredo, Barón-López, F. Javier, López-Miranda, José, Estruch, Ramón, Riquelme-Gallego, Blanca, Alonso-Gómez, Ángel, Tur, Josep A., Tinahones, Francisco J., Serra-Majem, Lluis, Martín, Vicente, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía, Pilar, Ros, Emilio, Fernández-Carrión, Rebeca, Díaz-López, Andrés, Zomeño, M. Dolors, Candela, Inmaculada, Konieczna, Jadwiga, Abete, Itziar, Buil-Cosiales, Pilar, Basora, Josep, Fitó, Montserrat, Martínez-González, Miguel A., and Bueno-Cavanillas, Aurora

Published
2020
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29. Association between Beverage Consumption and Environmental Sustainability in an Adult Population with Metabolic Syndrome

Author

García, Silvia, primary, Monserrat-Mesquida, Margalida, additional, Argelich, Emma, additional, Ugarriza, Lucía, additional, Salas-Salvadó, Jordi, additional, Bautista, Inmaculada, additional, Vioque, Jesús, additional, Zomeño, María Dolores, additional, Corella, Dolores, additional, Pintó, Xavier, additional, Bueno-Cavanillas, Aurora, additional, Daimiel, Lidia, additional, Martínez, J. Alfredo, additional, Nishi, Stephanie, additional, Herrera-Ramos, Estefanía, additional, González-Palacios, Sandra, additional, Fitó, Montserrat, additional, Asensio, Eva M., additional, Fanlo-Maresma, Marta, additional, Cano-Ibáñez, Naomi, additional, Cuadrado-Soto, Esther, additional, Abete, Itziar, additional, Tur, Josep A., additional, and Bouzas, Cristina, additional

Published
2024
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30. Association between dairy product consumption and hyperuricemia in an elderly population with metabolic syndrome

Author

Mena-Sánchez, Guillermo, Babio, Nancy, Becerra-Tomás, Nerea, Martínez-González, Miguel Á., Díaz-López, Andrés, Corella, Dolores, Zomeño, Maria D., Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, José A., Serra-Majem, Luís, Estruch, Ramon, Bernal, Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A., Lopez-Miranda, José, Cano-Ibáñez, Naomi, Gaforio, Jose J., Matía-Martín, Pilar, Daimiel, Lidia, Caro, José L. Llisterri, Vidal, Josep, Vázquez, Clotilde, Ros, Emili, Arellano, Ana Garcia, Palau, Antoni, Fernández-Carrión, Rebeca, Pérez-Vega, Karla A., Morey, Marga, de la Hera, Manoli García, Vaquero-Luna, Jessica, Carmona-González, Francisco J., Abete, Itziar, Álvarez-Pérez, Jacqueline, Casas, Rosa, Fernández-García, José C., Santos-Lozano, José M., Corbella, Emili, Sureda, Antoni, Ruiz-Canela, Miguel, Barragán, Rocio, Goday, Albert, Martín, Marian, Altozano Rodado, María C., Toledo, Estefanía, Fitó, Montse, and Salas-Salvadó, Jordi

Published
2020
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31. Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial

Author

Martínez-González, Miguel A, Fernandez-Lazaro, Cesar I, Toledo, Estefanía, Díaz-López, Andrés, Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M, Wärnberg, Julia, Martínez, J Alfredo, Serra-Majem, Luís, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Pintó, Xavier, Tur, Josep A, López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Sánchez, Vicente Martín, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Portoles, Olga, Soria-Florido, María, Konieczna, Jadwiga, Navarrete-Muñoz, Eva M, Tojal-Sierra, Lucas, Fernández-García, José C, Abete, Itziar, Henríquez-Sánchez, Patricia, Muñoz-Garach, Araceli, Santos-Lozano, José M, Corbella, Emili, del Mar Bibiloni, Maria, Becerra-Tomás, Nerea, Barragán, Rocío, Castañer, Olga, Fiol, Miquel, de la Hera, Manoli García, Belló-Mora, María C, Gea, Alfredo, Babio, Nancy, Fitó, Montse, Ruiz-Canela, Miguel, Zazpe, Itziar, and Salas-Salvadó, Jordi

Published
2020
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34. Objectively Measured Sleep Duration and Health-Related Quality of Life in Older Adults with Metabolic Syndrome: A One-Year Longitudinal Analysis of the PREDIMED-Plus Cohort.

Author

Marcos-Delgado, Alba, Martín-Sánchez, Vicente, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Schröder, Helmut, Martínez, Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José M., Álvarez-Pérez, Jacqueline, Bueno-Cavanillas, Aurora, Cano-Ibáñez, Naomi, Amezcua-Prieto, Carmen, and Hernández-Segura, Natalia

Abstract

The aim of our cross-sectional and longitudinal study is to assess the relationship between daytime and night-time sleep duration and health-related quality of life (HRQoL) in adults with metabolic syndrome after a 1-year healthy lifestyle intervention. Analysis of the data from 2119 Spanish adults aged 55–75 years from the PREDIMED-Plus study was performed. Sleep duration was assessed using a wrist-worn accelerometer. HRQoL was measured using the SF-36 questionnaire. Linear regression models adjusted for socioeconomic and lifestyle factors and morbidity were developed. In cross-sectional analyses, participants with extreme night-time sleep duration categories showed lower physical component summary scores in Models 1 and 2 [β-coefficient (95% confidence interval) <6 h vs. 7–9 h: −2, 3 (−3.8 to −0.8); p = 0.002. >9 h vs. 7–9 h: −1.1 (−2.0 to −0.3); p = 0.01]. Participants who sleep less than 7 h a night and take a nap are associated with higher mental component summary scores [β-coefficient (95% confidence interval) 6.3 (1.3 to 11.3); p = 0.01]. No differences between night-time sleep categories and 12-month changes in HRQoL were observed. In conclusion, in cross-sectional analyses, extremes in nocturnal sleep duration are related to lower physical component summary scores and napping is associated with higher mental component summary scores in older adults who sleep less than 7 h a night. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Association between low dairy intake during pregnancy and small for gestational age infants

Author

Olmedo-Requena, Rocío, Martínez-Galiano, Juan Miguel, Amezcua-Prieto, Carmen, Cano-Ibáñez, Naomi, Salcedo-Bellido, Inmaculada, Barrios-Rodríguez, Rocío, and Jiménez-Moleón, José Juan

Subjects
Newborn infants, Fetal development, Pregnancy, Pregnant women, Fetus -- Growth, Infants (Newborn)
Abstract

Author(s): Rocío Olmedo-Requena [sup.1] [sup.2] [sup.3], Juan Miguel Martínez-Galiano [sup.2] [sup.4], Carmen Amezcua-Prieto [sup.1] [sup.2] [sup.3], Naomi Cano-Ibáñez [sup.1] [sup.2] [sup.3], Inmaculada Salcedo-Bellido [sup.1] [sup.2] [sup.3], Rocío Barrios-Rodríguez [sup.1] [sup.2] [...], Maternal nutrition is recognized as one of the main determinants of fetal growth. We analyzed the risk of having a Small for Gestational Age (SGA) newborn according to maternal dairy intake during pregnancy. A matched case-control study was conducted in Spain. Dietary intake during pregnancy was assessed using a validated Food Frequency Questionnaire. Odds ratios (OR) and their 95% confidence intervals (CI) were estimated using conditional logistic regression models. 518 cases (SGA) and 518 controls (adequate birth weight) were included. Most study participants did not meet the current recommendations for dairy intake (78.6% cases and 80.2% controls). Intake of dairy products was not associated with a lower frequency of SGA, aOR.sub.Q4 vs. Q1 = 1.12 (95% CI 0.73, 1.70), and aOR.sub.Q5 vs. Q1 = 1.44 (95% CI 0.92, 2.26). Our results suggest that a low dairy intake during pregnancy is not associated with an increased risk of SGA; possibly due to the low consumption of dairy in both groups.

Published
2019
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36. Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk

Author

Donat-Vargas, Carolina, primary, Mico, Víctor, additional, San-Cristobal, Rodrigo, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Alonso-Gómez, Ángel Maria, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Damas-Fuentes, Miguel, additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep Antoni, additional, Cinza-Sanjurjo, Sergio, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Causso, Claudia, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Manzanares, Josep Maria, additional, Ortega-Azorín, Carolina, additional, Castañer, Olga, additional, Peña-Orihuela, Patricia Judith, additional, Zazo, Juan Manuel, additional, Muñoz Bravo, Carlos, additional, Martinez-Urbistondo, Diego, additional, Chaplin, Alice, additional, Casas, Rosa, additional, Cano Ibáñez, Naomi, additional, Tojal-Sierra, Lucas, additional, Gómez-Perez, Ana María, additional, Pascual Roquet-Jalmar, Elena, additional, Mestre, Cristina, additional, Barragán, Rocío, additional, Schröder, Helmut, additional, Garcia-Rios, Antonio, additional, Candela García, Inmaculada, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Malcampo, Mireia, additional, Daimiel, Lidia, additional, and Martínez, Alfredo, additional

Published
2023
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38. Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Author

Daimiel, Lidia, Martínez-González, Miguel A., Corella, Dolores, Salas-Salvadó, Jordi, Schröder, Helmut, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, Lopez-Miranda, Jose, Estruch, Ramón, Cano-Ibáñez, Naomi, Alonso-Gómez, Angel, Tur, Josep A., Tinahones, Francisco J., Serra-Majem, Lluis, Micó-Pérez, Rafael M., Lapetra, José, Galdón, Alba, Pintó, Xavier, Vidal, Josep, Micó, Victor, Colmenarejo, Gonzalo, Gaforio, José J., Matía, Pilar, Ros, Emilio, Buil-Cosiales, Pilar, Vázquez-Ruiz, Zenaida, Sorlí, José V., Graniel, Indira Paz, Cuenca-Royo, Aida, Gisbert-Sellés, Cristina, Galmes-Panades, Aina M., Zulet, M. Angeles, García-Ríos, Antonio, Díaz-López, Andrés, de la Torre, Rafael, Galilea-Zabalza, Iñigo, and Ordovás, José M.

Published
2020
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40. Additional file 1 of Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study

Author

Nishi, Stephanie K., Babio, Nancy, Paz-Graniel, Indira, Serra-Majem, Lluís, Vioque, Jesús, Fitó, Montserrat, Corella, Dolores, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Diez-Ricote, Laura, Martinez, J. Alfredo, Gómez-Martínez, Carlos, González-Botella, Andrés, Castañer, Olga, Alvarez-Sala, Andrea, Montesdeoca-Mendoza, Cristina, Fanlo-Maresma, Marta, Cano-Ibáñez, Naomi, Bouzas, Cristina, Daimiel, Lidia, Zulet, María Ángeles, Sievenpiper, John L., Rodriguez, Kelly L., Vázquez-Ruiz, Zenaida, and Salas-Salvadó, Jordi

Abstract

Additional file 1: Table S1. Hydration and water intake definitions. Table S2. Associations between cognitive assessments and water and fluid intake exposures. Table S3. Associations between cognitive assessments and EFSA fluid intake related guidelines. Table S4. Associations between cognitive assessments and hydration status. Table S5. Sensitivity analysis in global cognitive function according to water and fluid intake related exposures Table S6. Sensitivity analysis in global cognitive function according to EFSA fluid intake related guidelines. Table S7. Sensitivity analysis in global cognitive function according to hydration status. Fig. S1. Flow diagram of participants. Fig. S2. Continuous sensitivity analysis by sex. Fig. S3. Categorical sensitivity analysis by sex.

Published
2023
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41. Quality and reporting of statements on clinical trial integrity: A systematic review

Author

Furqan Ahmad Butt, Núñez-Núñez, María, Khan, Professor Khalid, Cano-Ibáñez, Naomi, Bartakke, Ashish Anil, and Bueno-Cavanillas, Aurora

Subjects
systematic review, Medicine and Health Sciences, research integrity, consensus statement, randomised control trials
Abstract

A research integrity statement is usually developed by an independent panel of multi-disciplinary experts convened to review the research literature in an evidence-based manner for the purpose of advancing the understanding of an issue, procedure or method (1). The integrity of randomised clinical trials (RCT) is essential for public trust in evidence-based medicine. We aim to appraise the quality and reporting of published research integrity statements related to any aspect of the RCT lifecycle. 1. Mosby's medical dictionary (2009). St. Louis, Mo: Mosby Elsevier.

Published
2023
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44. Patient and public involvement in lifestyle randomized controlled trials: a systematic review

Author

Bouzalmate-Hajjaj, Amira, Cano-Ibáñez, Naomi, Khan, Khalid Saeed, Bueno-Cavanillas, Aurora, and Guijarro, Paloma Massó

Abstract

Background: Motivating patients to take part in randomized controlled trials (RCTs) is challenging. Patient and public involvement (PPI), recommended for reporting since 2011, may potentially improve the recruitment and retention of participants in research. Aim: In this systematic review we aimed to identify the extent of PPI reported in RCTs of lifestyle interventions amongst adults and its impact on enrolment and retention rates. Methods: After prospective registration in PROSPERO (CRD42022359833), we searched the MEDLINE, Scopus, Web of Science, and Cochrane Library databases from inception to December 2022. We included RCTs with dietary interventions, with or without physical activity, and with or without behavioural support, among adults with overweight, obesity, or metabolic syndrome. Data extraction and study quality assessment were performed independently by two reviewers. Results: Of 1063 records, 26 RCTs (12,100 participants) were included. Among these, 22 were published after 2011. Of the total, 17 (65%) RCTs mentioned PPI directly (two studies) or indirectly. The methodological quality was high in 13 studies (50%), with no significant differences in PPI (p-value = 0.3187). The enrolment rate was no different but the median retention rate was high among RCTs with PPI (0.90; 95% CI 0.86–0.95) compared to those without (0.83; 95% CI 0.70–0.87) (p-value = 0.0426). Conclusion: PPI improved the retention of participants in RCTs with lifestyle interventions. However, its impact on enrolment was not clear. Overall, PPI should be encouraged in the RCT research process.

Published
2024
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46. Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study

Author

Riquelme-Gallego, Blanca, primary, García-Molina, Laura, additional, Cano-Ibáñez, Naomi, additional, Andújar-Vera, Francisco, additional, González-Salvatierra, Sheila, additional, García-Fontana, Cristina, additional, Bueno-Cavanillas, Aurora, additional, Muñoz-Torres, Manuel, additional, and García-Fontana, Beatriz, additional

Published
2022
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47. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial

Author

Cano-Ibáñez, Naomi, primary, Serra-Majem, Lluis, additional, Martín-Peláez, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Lassale, Camille, additional, Martínez, Jose Alfredo, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Gómez-Pérez, Ana María, additional, Lapetra, José, additional, Fernández-Aranda, Fernando, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A, additional, Cubelos, Naiara, additional, Pintó, Xavier, additional, Gaforio, José Juan, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Calderón, Cristina, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Gea, Alfredo, additional, Babio, Nancy, additional, Gimenez-Alba, Ignacio Manuel, additional, Zomeño-Fajardo, María Dolores, additional, Abete, Itziar, additional, Tojal Sierra, Lucas, additional, Romero-Galisteo, Rita P, additional, García de la Hera, Manoli, additional, Martín-Padillo, Marian, additional, García-Ríos, Antonio, additional, Casas, Rosa M, additional, Fernández-García, JC, additional, Santos-Lozano, José Manuel, additional, Toledo, Estefanía, additional, Becerra-Tomas, Nerea, additional, Sorli, Jose V, additional, Schröder, Helmut, additional, Zulet, María A, additional, Sorto-Sánchez, Carolina, additional, Diez-Espino, Javier, additional, Gómez-Martínez, Carlos, additional, Fitó, Montse, additional, and Sánchez-Villegas, Almudena, additional

Published
2022
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48. Associations Between the Modified Food Standard Agency Nutrient Profiling System Dietary Index and Cardiovascular Risk Factors in an Elderly Population

Author

Khoury, Nadine, primary, Gómez-Donoso, Clara, additional, Martínez, María Ángeles, additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, León-Acuña, Ana, additional, Tinahones, Francisco J., additional, Santos-Lozano, José M., additional, Serra-Majem, Luís, additional, Massó Guijarro, Paloma, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Bes-Rastrollo, Maira, additional, Barragan, Rocio, additional, Castañer, Olga, additional, Torres-Peña, Jose D., additional, Notario-Barandiaran, Leyre, additional, Muñoz-Bravo, Carlos, additional, Abete, Itziar, additional, Prohens, Lara, additional, Cano-Ibáñez, Naomi, additional, Tojal Sierra, Lucas, additional, Fernández-García, José Carlos, additional, Sayon-Orea, Carmen, additional, Pascual, Maria, additional, Sorli, Jose V., additional, Zomeño, Dolores, additional, Peña-Orihuela, Patricia J., additional, Signes-Pastor, Antonio J., additional, Basterra-Gortari, F. Javier, additional, Schröeder, Helmut, additional, Salas Salvadó, Jordi, additional, and Babio, Nancy, additional

Published
2022
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49. Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Author

Tresserra Rimbau, Anna, Castro Barquero, Sara, Becerra Tomás, Nerea, Babio, Nancy, Martínez González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel M., Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, Cano Ibáñez, Naomi, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Francisco Javier, Fernández de la Puente, María, Asensio, Eva María, Castañer, Olga, Bullón Vela, Vanessa, Tojal Sierra, Lucas, Gómez Gracia, Enrique, Cases Pérez, Eugenio, Konieczna, Jadwiga, García Ríos, Antonio, Casañas Quintana, Tamara, Bernal López, María Rosa, Santos Lozano, José Manuel, Esteve Luque, Virginia, Bouzas, Cristina, Vázquez Ruiz, Zenaida, Palau Galindo, Antoni, Barragan, Rocio, López Grau, Mercè, Razquín, Cristina, Goicolea Güemez, Leire, Toledo, Estefanía, Vergaz, Manel Vila, Lamuela Raventós, Rosa María, Salas Salvadó, Jordi, Tresserra Rimbau, Anna, Castro Barquero, Sara, Becerra Tomás, Nerea, Babio, Nancy, Martínez González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel M., Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, Cano Ibáñez, Naomi, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Francisco Javier, Fernández de la Puente, María, Asensio, Eva María, Castañer, Olga, Bullón Vela, Vanessa, Tojal Sierra, Lucas, Gómez Gracia, Enrique, Cases Pérez, Eugenio, Konieczna, Jadwiga, García Ríos, Antonio, Casañas Quintana, Tamara, Bernal López, María Rosa, Santos Lozano, José Manuel, Esteve Luque, Virginia, Bouzas, Cristina, Vázquez Ruiz, Zenaida, Palau Galindo, Antoni, Barragan, Rocio, López Grau, Mercè, Razquín, Cristina, Goicolea Güemez, Leire, Toledo, Estefanía, Vergaz, Manel Vila, Lamuela Raventós, Rosa María, and Salas Salvadó, Jordi

Abstract

The PREDIMED-Plus trial was supported by the Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V. (Josep Vidal), including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158)), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil for the PTREDIMED-Plus study, and, Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D., Unión Europea, Consejo Europeo de Investigación, Ministerio de Ciencia y Innovación (España), Ministerio de Economía e Industria (España), Junta de Andalucía. Consejería de Salud, Generalitat Valenciana, Gobierno de Islas Baleares, Instituto de Salud Carlos III, Recercaixa, ICREA, PREDIMED-Plus, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2022

50. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

Author

Universidad de Sevilla. Departamento de Medicina, Consejo Europeo de Investigación, Gobierno de España, Instituto de Salud Carlos III, Martín-Peláez, Sandra, Serra-Majem, Lluis, Cano-Ibáñez, Naomi, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Santos Lozano, José Manuel, Sánchez-Villegas, Almudena, Universidad de Sevilla. Departamento de Medicina, Consejo Europeo de Investigación, Gobierno de España, Instituto de Salud Carlos III, Martín-Peláez, Sandra, Serra-Majem, Lluis, Cano-Ibáñez, Naomi, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Santos Lozano, José Manuel, and Sánchez-Villegas, Almudena

Abstract

Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55–75 years) with metabolic syn drome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240–279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabe tes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870). Introduction Cardiovascular disease (CVD) is the main cause of mortality worldwide [1]

Published
2022

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