Author: "Cano Daniel" - Searchworks@Jio Institute Digital Library Search Results

1,226 results on '"Cano Daniel"'

1. Identified Opportunities in Utilization of the European Research Reactor Fleet as a Part of the TOURR Project

Author: Pungerčič Anže, Cirillo Roberta, Walkiewicz Joanna, Novák Evžen, Gajewski Jacek, Szentmiklósi Laszlo, Van Puyvelde Lisanne, Starflinger Jörg, Cano Daniel, Pohlner Georg, Mikolajczak Renata, Pavel Gabriel, and Snoj Luka
Subjects: research reactor, tourr, european reactors, utilization, research reactor applications, Physics, QC1-999
Abstract: This paper discusses the current status of the European research reactor (RR) fleet and identified opportunities for its utilization. The data for this analysis was collected through a specific questionnaire from which a database of the European RR fleet was created. The questionnaire was designed to assess the degree of exploitation of different RR applications and to identify gaps and opportunities for future utilization. The results indicate that the European RR fleet is older compared to the world average, with no new research reactors built in Europe since 1992. The majority of RRs reported low levels of exploitation across all applications, and a desire to expand utilization was expressed by 78% of respondents. Lack of manpower, finance, and customers were identified as the main obstacles preventing expansion, while the need for more nuclear engineers was identified as a clear opportunity to attract people to the field. The findings of this study emphasize the need for actions to be taken to combat future needs and to improve the utilization of the European RR fleet. Overall, this study provides valuable insights for policymakers, industry professionals, and researchers working in the field of nuclear energy.
Published: 2023
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2. An improved Halo Occupation Distribution prescription from UNITsim H_alpha Emission Line Galaxies: conformity and modified radial profile

Author: Reyes-Peraza, Guillermo, Avila, Santiago, Gonzalez-Perez, Violeta, Lopez-Cano, Daniel, Knebe, Alexander, Ramakrishnan, Sujatha, and Yepes, Gustavo
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: Emission line galaxies (ELGs) are targeted by the new generation of spectroscopic surveys to make unprecedented measurements in cosmology from their distribution. Accurately interpreting this data requires understanding the imprints imposed by the physics of galaxy formation and evolution on galaxy clustering. In this work we utilize a semi-analytical model of galaxy formation (SAGE) to explore the necessary components for accurately reproducing the clustering of ELGs. We focus on developing a Halo Occupation Distribution (HOD) prescription able to reproduce the clustering of SAGE galaxies. Typically, HOD models assume that satellite and central galaxies of a given type are independent events. We investigate the need for conformity, i.e. whether the average satellite occupation depends on the existence of a central galaxy of a given type. Incorporating conformity into HOD models is crucial for reproducing the clustering in the reference galaxy sample. Another aspect we investigate is the radial distribution of satellite galaxies within haloes. The traditional density profile models, NFW and Einasto profiles, fail to accurately replicate the small-scale clustering measured for SAGE satellite galaxies. To overcome this limitation, we propose a generalization of the NFW profile, thereby enhancing our understanding of galaxy clustering., Comment: 17 pages, 12 figures and 5 tables
Published: 2023

3. Characterizing Structure Formation through Instance Segmentation

Author: López-Cano, Daniel, Stücker, Jens, Ibañez, Marcos Pellejero, Angulo, Raúl E., and Franco-Barranco, Daniel
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Dark matter haloes form from small perturbations to the almost homogeneous density field of the early universe. Although it is known how large these initial perturbations must be to form haloes, it is rather poorly understood how to predict which particles will end up belonging to which halo. However, it is this process that determines the Lagrangian shape of protohaloes and is therefore essential to understand their mass, spin and formation history. Here, we present a machine-learning framework to learn how the protohalo regions of different haloes emerge from the initial density field. This involves one neural network to distinguish semantically which particles become part of any halo and a second neural network that groups these particles by halo membership into different instances. This instance segmentation is done through the Weinberger method, in which the network maps particles into a pseudo-space representation where different instances can be distinguished easily through a simple clustering algorithm. Our model reliably predicts the masses and Lagrangian shapes of haloes object-by-object, as well as summary statistics like the halo-mass function. We find that our model extracts information close to optimal by comparing it to the degree of agreement between two N-body simulations with slight differences in their initial conditions. We publish our model open-source and suggest that it can be used to inform analytical methods of structure formation by studying the effect of systematic manipulations of the initial conditions., Comment: 19 pages, 18 figures. Comments are welcome. Public code: https://github.com/daniellopezcano/instance_halos. Typos corrected, references added
Published: 2023

4. Vitamin D receptor and its antiproliferative effect in human pulmonary arterial hypertension

Author: Callejo, Maria, Morales-Cano, Daniel, Olivencia, Miguel A., Mondejar-Parreño, Gema, Barreira, Bianca, Tura-Ceide, Olga, Martínez, Victor G., Serrano-Navarro, Alvaro, Moreno, Laura, Morrell, Nick, Perros, Frédéric, Vicente, Angeles, Cogolludo, Angel, and Perez-Vizcaino, Francisco
Published: 2024
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5. Effects of experimental impairments on the security of continuous-variable quantum key distribution

Author: Ruiz-Chamorro, Andres, Cano, Daniel, Garcia-Callejo, Aida, and Fernandez, Veronica
Subjects: Quantum Physics
Abstract: Quantum Key Distribution (QKD) is a cutting-edge communication method that enables secure communication between two parties. Continuous-variable QKD (CV-QKD) is a promising approach to QKD that has several advantages over traditional discrete-variable systems. Despite its potential, CV-QKD systems are highly sensitive to optical and electronic component impairments, which can significantly reduce the secret key rate. In this research, we address this challenge by modeling a CV-QKD system to simulate the impact of individual impairments on the secret key rate. The results show that laser frequency drifts and small imperfections in electro-optical devices such as the beam splitter and the balanced detector have a negative impact on the secret key rate. This provides valuable insights into strategies for optimizing the performance of CV-QKD systems and overcome limitations caused by component impairments. By offering a method to analyze them, the study enables the establishment of quality standards for the components of CV-QKD systems, driving the development of advanced technologies for secure communication in the future.
Published: 2023

6. A Generalization of Magnetic Curves in Contact Metric Geometry

Author: Alegre, Pablo, Barrera, Joaquín, Carriazo, Alfonso, and García-Cano, Daniel
Published: 2024
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7. Optimising Region of Interest Registration for Multiple-Tissue Whole Slide Images

Author: Fiorin, Alessio, Adalid Llansa, Laia, Goyda, Elena, Della Mea, Vincenzo, Korzynska, Anna, Abdelazeez, Shrief, Bosch Príncep, Ramon, Fischer Carles, Alba, Gallardo Borràs, Noelia, Lejeune, Marylène, Mata Cano, Daniel, Puig, Domenec, Rashwan, Hatem A., Sauras Colón, Esther, Relloso Ortiz de Uriarte, Mikel, Reverté Calvet, Laia, López Pablo, Carlos, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Modat, Marc, editor, Simpson, Ivor, editor, Špiclin, Žiga, editor, Bastiaansen, Wietske, editor, Hering, Alessa, editor, and Mok, Tony C. W., editor
Published: 2024
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8. Cholesterol lowering depletes atherosclerotic lesions of smooth muscle cell-derived fibromyocytes and chondromyocytes

Author: Carramolino, Laura, Albarrán-Juárez, Julián, Markov, Anton, Hernández-SanMiguel, Esther, Sharysh, Diana, Cumbicus, Vanessa, Morales-Cano, Daniel, Labrador-Cantarero, Verónica, Møller, Peter Loof, Nogales, Paula, Benguria, Alberto, Dopazo, Ana, Sanchez-Cabo, Fátima, Torroja, Carlos, and Bentzon, Jacob F.
Published: 2024
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9. The cosmology dependence of the concentration-mass-redshift relation

Author: López-Cano, Daniel, Angulo, Raúl E., Ludlow, Aaron D., Zennaro, M., Contreras, S., Chaves-Montero, Jonás, and Aricò, G.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The concentrations of dark matter haloes provide crucial information about their internal structure and how it depends on mass and redshift -- the so-called concentration-mass-redshift relation, denoted $c(M,z)$. We present here an extensive study of the cosmology-dependence of $c(M,z)$ that is based on a suite of 72 gravity-only, full N-body simulations in which the following cosmological parameters were varied: $\sigma_{8}$, $\Omega_{\mathrm{M}}$, $\Omega_{\mathrm{b}}$, $n_{\mathrm{s}}$, $h$, $M_{\nu}$, $w_{0}$ and $w_{\mathrm{a}}$. We characterize the impact of these parameters on concentrations for different halo masses and redshifts. In agreement with previous works, and for all cosmologies studied, we find that there exists a tight correlation between the characteristic densities of dark matter haloes within their scale radii, $r_{-2}$, and the critical density of the Universe at a suitably defined formation time. This finding, when combined with excursion set modelling of halo formation histories, allows us to accurately predict the concentrations of dark matter haloes as a function of mass, redshift, and cosmology. We use our simulations to test the reliability of a number of published models for predicting halo concentration and highlight when they succeed or fail to reproduce the cosmological $c(M,z)$ relation., Comment: 11 pages, 9 figures
Published: 2022
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10. Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities.

Author: Kumar, Rahul, Aktay-Cetin, Öznur, Craddock, Vaughn, Morales-Cano, Daniel, Kosanovic, Djuro, Cogolludo, Angel, Perez-Vizcaino, Francisco, Avdeev, Sergey, Kumar, Ashok, Ram, Anil Kumar, Agarwal, Stuti, Chakraborty, Ananya, Savai, Rajkumar, de Jesus Perez, Vinicio, Graham, Brian B, Butrous, Ghazwan, and Dhillon, Navneet K
Subjects: Lung, Humans, Cross Reactions, Coinfection, COVID-19, SARS-CoV-2, Pneumonia & Influenza, Biodefense, Immunization, Vaccine Related, Prevention, Emerging Infectious Diseases, Infectious Diseases, Pneumonia, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Infection, Respiratory, Good Health and Well Being, Microbiology, Immunology, Medical Microbiology, Virology
Abstract: The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases.
Published: 2023

11. Photon statistics of the light transmitted and reflected by a two-dimensional atomic array

Author: Cano, Daniel
Subjects: Quantum Physics
Abstract: This work proposes to investigate the photon statistics of the light transmitted and reflected by a two-dimensional array of interacting atoms. The reflected beam is characterized by photon antibunching. On the other hand, in the transmitted beam the indistinguishability between the driving laser photons and the photons re-emitted by the atoms results in photon bunching. The overlap between the driving and scattered fields is enhanced by the cooperative optical response of the atomic array. In the examples used in this paper, up to 25\% of the transmitted photons are grouped in pairs. The simulations are carried out using the stochastic method of quantum trajectories.
Published: 2021
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12. Immediate effect of hallux valgus surgery on the biomechanical behavior of the first ray

Author: Cano, Daniel Poggio, Lagos, Matías Andaur, Baduell, Albert, González, José Tomás Aldunate, Torre, Carolina Montoya de la, and Rios, J.
Published: 2024
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13. Ultrasound evaluation of a new surface reference line to describe sural nerve location and safe zones to consider in posterior leg approaches

Author: Ruiz-Riquelme, Pablo, Poggio-Cano, Daniel, Sala-Blanch, Xavier, Cuéllar Bernal, Daniel, Baduell, Albert, Garcia-Elvira, Rubén, and Testa, Enrique Adrián
Published: 2023
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14. HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape

Author: Medrano-Garcia, Sandra, Morales-Cano, Daniel, Barreira, Bianca, Vera-Zambrano, Alba, Kumar, Rahul, Kosanovic, Djuro, Schermuly, Ralph Theo, Graham, Brian B, Perez-Vizcaino, Francisco, Mathie, Alistair, Savai, Rajkumar, Pullamseti, Soni, Butrous, Ghazwan, Fernández-Malavé, Edgar, and Cogolludo, Angel
Subjects: Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Lung, Infectious Diseases, HIV/AIDS, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Infection, Cardiovascular, Good Health and Well Being, Animals, Cytokines, HIV Infections, Humans, Mice, Mice, Inbred C57BL, Schistosoma mansoni, Schistosomiasis mansoni, Vascular Diseases, HIV, schistosomiasis, pulmonary arterial hypertension, inflammation, pulmonary endothelium, pulmonary vascular remodeling, Biological sciences, Biomedical and clinical sciences
Abstract: HIV and Schistosoma infections have been individually associated with pulmonary vascular disease. Co-infection with these pathogens is very common in tropical areas, with an estimate of six million people co-infected worldwide. However, the effects of HIV and Schistosoma co-exposure on the pulmonary vasculature and its impact on the development of pulmonary vascular disease are largely unknown. Here, we have approached these questions by using a non-infectious animal model based on lung embolization of Schistosoma mansoni eggs in HIV-1 transgenic (HIV) mice. Schistosome-exposed HIV mice but not wild-type (Wt) counterparts showed augmented pulmonary arterial pressure associated with markedly suppressed endothelial-dependent vasodilation, increased endothelial remodeling and vessel obliterations, formation of plexiform-like lesions and a higher degree of perivascular fibrosis. In contrast, medial wall muscularization was similarly increased in both types of mice. Moreover, HIV mice displayed an impaired immune response to parasite eggs in the lung, as suggested by decreased pulmonary leukocyte infiltration, small-sized granulomas, and augmented residual egg burden. Notably, vascular changes in co-exposed mice were associated with increased expression of proinflammatory and profibrotic cytokines, including IFN-γ and IL-17A in CD4+ and γδ T cells and IL-13 in myeloid cells. Collectively, our study shows for the first time that combined pulmonary persistence of HIV proteins and Schistosoma eggs, as it may occur in co-infected people, alters the cytokine landscape and targets the vascular endothelium for aggravated pulmonary vascular pathology. Furthermore, it provides an experimental model for the understanding of pulmonary vascular disease associated with HIV and Schistosoma co-morbidity.
Published: 2022

15. UNITSIM-Galaxies: data release and clustering of emission-line galaxies

Author: Knebe, Alexander, Lopez-Cano, Daniel, Avila, Santiago, Favole, Ginevra, Stevens, Adam R. H., Gonzalez-Perez, Violeta, Reyes-Peraza, Guillermo, Yepes, Gustavo, Chuang, Chia-Hsun, and Kitaura, Francisco-Shu
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: New surveys such as ESA's Euclid mission are planned to map with unprecedented precision the large-scale structure of the Universe by measuring the 3D positions of tens of millions of galaxies. It is necessary to develop theoretically modelled galaxy catalogues to estimate the expected performance and to optimise the analysis strategy of these surveys. We populate two pairs of (1 Gpc/h)^3 volume dark-matter-only simulations from the UNIT project with galaxies using the SAGE semi-analytic model of galaxy formation, coupled to the photoionisation model get_emlines to estimate their H_alpha emission. These catalogues represent a unique suite that includes galaxy formation physics and - thanks to the fixed-pair technique used - an effective volume of ~(5 Gpc/h)^3, which is several times larger than the Euclid survey. We present the performance of these data and create five additional emission-line galaxy (ELG) catalogues by applying a dust attenuation model as well as adjusting the flux threshold as a function of redshift in order to reproduce Euclid-forecast dN/dz values. As a first application, we study the abundance and clustering of those model H_alpha ELGs: for scales greater than ~5 Mpc/h, we find a scale-independent bias with a value of $b\sim 1$ at redshift z ~ 0.5, that can increase nearly linearly to $b\sim 4$ at $z\sim 2$, depending on the ELG catalogue. Model galaxy properties, including their emission-line fluxes (with and without dust extinction) are publicly available., Comment: 16 pages, revised version as accepted by MNRAS
Published: 2021
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16. A Review on Continuous-Variable Quantum Key Distribution Security

Author: Garcia-Callejo, Aida, Ruiz-Chamorro, Andres, Cano, Daniel, Fernandez, Veronica, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Bravo, José, editor, Ochoa, Sergio, editor, and Favela, Jesús, editor
Published: 2023
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17. Sub-Poissonian atom-number distributions by means of Rydberg dressing and electromagnetically induced transparency

Author: Cano, Daniel
Subjects: Quantum Physics
Abstract: A method is proposed to produce atomic ensembles with sub-Poissonian atom number distributions. The method consists of removing the excess atoms using the interatomic interactions induced by Rydberg dressing. The selective removal of atoms occurs via spontaneous decay into untrapped states using an electromagnetically induced transparency scheme. Ensembles with the desired number of atoms can be produced almost deterministically. Numerical simulations predict a strong reduction of the atom number fluctuations, with the variance twenty times less than the Poisson noise level (the predicted Fano factor is F = 0.05). Strikingly, the method is suitable for both fermions and bosons. It solves the problem of the atom-number fluctuations in bosons, whose weak interactions have usually been an obstacle to controlling the number of atoms.
Published: 2020
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18. Fast electrical modulation of strong near-field interactions between erbium emitters and graphene

Author: Cano, Daniel, Ferrier, Alban, Soundarapandian, Karuppasamy, Reserbat-Plantey, Antoine, Scarafagio, Marion, Tallaire, Alexandre, Seyeux, Antoine, Marcus, Philippe, de Riedmatten, Hugues, Goldner, Philippe, Koppens, Frank H. L., and Tielrooij, Klaas-Jan
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Optics, Quantum Physics
Abstract: Combining the quantum optical properties of single-photon emitters with the strong near-field interactions available in nanophotonic and plasmonic systems is a powerful way of creating quantum manipulation and metrological functionalities. The ability to actively and dynamically modulate emitter-environment interactions is of particular interest in this regard. While thermal, mechanical and optical modulation have been demonstrated, electrical modulation has remained an outstanding challenge. Here we realize fast, all-electrical modulation of the near-field interactions between a nanolayer of erbium emitters and graphene, by in-situ tuning the Fermi energy of graphene. We demonstrate strong interactions with a >1,000-fold increased decay rate for 25% of the emitters, and electrically modulate these interactions with frequencies up to 300 kHz - orders of magnitude faster than the emitters radiative decay (100 Hz). This constitutes an enabling platform for integrated quantum technologies, opening routes to quantum entanglement generation by collective plasmon emission or photon emission with controlled waveform., Comment: to be published in Nat Commun
Published: 2020
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19. The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit

Author: Villegas-Esguevillas, Marta, Cho, Suhan, Vera-Zambrano, Alba, Kwon, Jae Won, Barreira, Bianca, Telli, Göcken, Navarro-Dorado, Jorge, Morales-Cano, Daniel, de Olaiz, Beatriz, Moreno, Laura, Greenwood, Iain, Pérez-Vizcaíno, Francisco, Kim, Sung Joon, Climent, Belén, and Cogolludo, Angel
Published: 2023
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20. Chotan hin ay ti’ ha Yichk’u

Author: Caño, Daniel
Published: 2022

21. Chotan hin ay ti’ha Yichk’u

Author: Caño, Daniel
Published: 2022

22. The Akin osteotomy without fixation in open hallux abducto-valgo correction surgery – A single center retrospective analysis of 286 cases

Author: Testa, Enrique Adrian, Porreca, Annamaria, Nasarre, Alberto Ruiz, Cano, Daniel Poggio, Goenaga, Fernando Alvarez, Ledermann, Gerardo, Baduell, Albert, and Riquelme, Pablo Ruiz
Published: 2023
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23. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

Author: Buunk, Annemarie, Goossens, Hanneke, Baas, Gert, Algera, Maartje, Schuil-Vlassak, Evelyn, Ambagts, Thijs, De Hoog-Schouten, Leonie, Musaafir, Sara, Bosch, Roelof, Tjong, Carol, Steeman, Sanne, Van der Plas, Martine, Baldew, Glenn, Den Hollander, Iris, De Waal, Zacharias, Heijn, Aurele, Nelemans, Leen, Kouwen-Lubbers, Kirsten, Van Leeuwen, Maartje, Hoogenboom, Sacha, Van Doremalen, Jacobine, Ton, Célin, Beetstra, Bastien, Meijs, Veronique, Dikken, Jan, Dubero, Dasha, Slager, Mark, Houben, Tom, Kanis, Thomas, Overmars, Wietske, Nijenhuis, Marga, Steffens, Michael, Bergs, Ingmar, Karamperis, Kariofyllis, Siamoglou, Stavroula, Ivantsik, Ouliana, Samiou, Georgia-Chryssa, Kordou, Zoe, Tsermpini, Evira, Ferentinos, Panagiotis, Karaivazoglou, Aikaterini, Rigas, George, Gerasimou, Harilaos, Voukelatou, Georgia, Georgila, Eleni, Tsermpini, Evangelia Eirini, Mendrinou, Efrossyni, Chalikiopoulou, Konstantina, Kolliopoulou, Alexandra, Mitropoulos, Konstantinos, Stratopoulos, Apostolos, Liopetas, Ioannis, Tsikrika, Athina, Barba, Evangelia, Emmanouil, Georgia, Stamopoulou, Theano, Stathoulias, Andreas, Giannopoulos, Panagiotis, Kanellakis, Filippos, Bartsakoulia, Marina, Katsila, Theodora, Douzenis, Athanassios, Gourzis, Filippos, Assimakopoulos, Konstantinos, Bignucolo, Alessia, Dal Cin, Lisa, Comello, Francesco, Mezzalira, Silvia, Puglisi, Fabio, Spina, Michele, Foltran, Luisa, Guardascione, Michela, Buonadonna, Angela, Bartoletti, Michele, Corsetti, Serena, Ongaro, Elena, Da Ros, Lucia, Bolzonello, Silvia, Spazzapan, Simon, Freschi, Andrea, Di Nardo, Paola, Palazzari, Elisa, Navarria, Federico, Innocente, Roberto, Berretta, Massimiliano, D'Andrea, Mario, Angelini, Francesco, Diraimo, Tania, Favaretto, Adolfo, Dávila-Fajardo, Cristina Lucía, Díaz-Villamarín, Xando, Martínez-González, Luis Javier, Antúnez-Rodríguez, Alba, Moreno-Escobar, Eduardo, Fernández-Gómez, Ana Estefanía, García-Navas, Paloma, Bautista-Pavés, Alicia Bautista Pavés, Burillo-Gómez, Francisco, Villegas-Rodríguez, Inmaculada, Sánchez-Ramos, Jesús Gabriel, Antolinos-Pérez, Mª José, Rivera, Ricardo, Martínez-Huertas, Susana, Thomas-Carazo, Jesús, Yañez-Sanchez, Jose Julio, Blancas-López-Barajas, Mª Isabel, García-Orta, Rocío, González-Astorga, Beatriz, Rodríguez-González, Carlos José, Ruiz-Carazo, Francisco Javier, Pérez-Campos, Manuel, Cano-Herrera, Irene, Herrera, Rosa, Gil-Jiménez, Teresa, Delgado-Ureña, Mª Teresa, Triviño-Juarez, Jose Matías, Campos-Velázquez, Salustiano, Alcántara- Espadafor, Silvia, Moreno Aguilar, Maria Rosario, Ontiveros- Ortega, Maria Carmen, Carnerero-Córdoba, Lidia, Guerrero-Jiménez, Margarita, Legeren- Álvarez, Marta, Yélamos-Vargas, Marisol, Castillo-Pérez, Isabel, Aomar-Millán, Ismael, Anguita-Romero, Manuel, Sánchez-García, María José, Sequero-Lopez, Silvia, Faro-Miguez, Naya, López-Fernández, Silvia, Leyva-Ferrer, Rosario Nieves, Herrera-Gómez, Norberto, Pertejo-Manzano, Laura, Pérez-Gutierrez, Eva Mª, Martín-de la Higuera, Antonio J., Plaza-Carrera, Jose, Baena-Garzón, Flor, Toledo-Frías, Pablo, Cruz-Valero, Inés, Chacón-McWeeny, Verónica, Gallardo- Sánchez, Isabel, Arrebola, Antonio, Guillén-Zafra, Lucía, Ceballos-Torres, Ángel, Guardia-Mancilla, Plácido, Guirao-Arrabal, Emilio, Canterero-Hinojosa, Jesús, Velasco-Fuentes, Sara, Sánchez- Cano, Daniel, Aguilar-Jaldo, Mª del Pilar, Caballero-Borrego, Juan, Praznik, Monika, Slapšak, Urška, Voncina, Blaz, Rajter, Branka, Škrinjar, Andrej, Marjetic Ulcakar, Angelika, Zidanšek, Anja, Stegne Ignjatvic, Tea, Mazej Poredoš, Barbara, Vivod Pecnik, Živka, Poplas Susic, Tonka, Juteršek, Milojka, Klen, Jasna, Skoporc, Janja, Kotar, Tjaša, Petek Šter, Marija, Zvezdana Dernovšk, Mojca, Mlinšek, Gregor, Miklavcic, Petra, Plemenitaš Ilješ, Anja, Grašic Kuhar, Cvetka, Oblak, Irena, Stražišar, Branka, Štrbac, Danijela, Matos, Erika, Mencinger, Marina, Vrbnjak, Marko, Saje, Marko, Radovanovic, Mirjana, Jeras, Katja, Bukovec, Lucija, Terzic, Tea, Minichmayr, Iris, Nanah, Abdulaziz, Nielsen, Elisabet, Zou, Yuanxi, Lauschke, Volker, Johansson, Inger, Zhou, Yitian, Nordling, Åsa, Aigner, Christof, Dames-Ludwig, Marlies, Monteforte, Rossella, Sunder-Plassmann, Raute, Steinhauser, Corinna, Sengoelge, Guerkan, Winnicki, Wolfgang, Schmidt, Alice, Vasileios, Fragoulakis, Fontana, Vanessa, Hanson, Anita, Little, Margaret, Hornby, Rachael, Dello Russo, Cinzia, French, Stephanie, Hampson, Jamie, Gumustekin, Mukaddes, Anyfantis, George, Hampson, Lucy, Lewis, David, Westhead, Ruth, Prince, Clare, Rajasingam, Arjunan, Swen, Jesse J, van der Wouden, Cathelijne H, Manson, Lisanne EN, Abdullah-Koolmees, Heshu, Blagec, Kathrin, Blagus, Tanja, Böhringer, Stefan, Cambon-Thomsen, Anne, Cecchin, Erika, Cheung, Ka-Chun, Deneer, Vera HM, Dupui, Mathilde, Ingelman-Sundberg, Magnus, Jonsson, Siv, Joefield-Roka, Candace, Just, Katja S, Karlsson, Mats O, Konta, Lidija, Koopmann, Rudolf, Kriek, Marjolein, Lehr, Thorsten, Mitropoulou, Christina, Rial-Sebbag, Emmanuelle, Rollinson, Victoria, Roncato, Rossana, Samwald, Matthias, Schaeffeler, Elke, Skokou, Maria, Schwab, Matthias, Steinberger, Daniela, Stingl, Julia C, Tremmel, Roman, Turner, Richard M, van Rhenen, Mandy H, Dávila Fajardo, Cristina L, Dolžan, Vita, Patrinos, George P, Pirmohamed, Munir, Sunder-Plassmann, Gere, Toffoli, Giuseppe, and Guchelaar, Henk-Jan
Published: 2023
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24. A pluripotent stem cell platform for in vitro systems genetics studies of mouse development

Author: Glenn, Rachel A., primary, Do, Stephanie C., additional, Guruvayurappan, Karthik, additional, Corrigan, Emily K., additional, Santini, Laura, additional, Medina-Cano, Daniel, additional, Singer, Sarah, additional, Cho, Hyein, additional, Liu, Jing, additional, Broman, Karl, additional, Czechanski, Anne, additional, Reinholdt, Laura, additional, Koche, Richard, additional, Furuta, Yasuhide, additional, Kunz, Meik, additional, and Vierbuchen, Thomas, additional
Published: 2024
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25. Correction to: Ultrasound evaluation of a new surface reference line to describe sural nerve location and safe zones to consider in posterior leg approaches

Author: Ruiz-Riquelme, Pablo, Poggio-Cano, Daniel, Sala-Blanch, Xavier, Cuéllar-Bernal, Daniel, Baduell, Albert, Garcia-Elvira, Rubén, and Testa, Enrique Adrián
Published: 2023
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26. A Review on Continuous-Variable Quantum Key Distribution Security

Author: Garcia-Callejo, Aida, primary, Ruiz-Chamorro, Andres, additional, Cano, Daniel, additional, and Fernandez, Veronica, additional
Published: 2022
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27. Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma‐Pulmonary Hypertension

Author: Kumar, Rahul, Mickael, Claudia, Kassa, Biruk, Sanders, Linda, Koyanagi, Dan, Hernandez‐Saavedra, Daniel, Freeman, Scott, Morales‐Cano, Daniel, Cogolludo, Angel, McKee, Amy S, Fontenot, Andrew P, Butrous, Ghazwan, Tuder, Rubin M, and Graham, Brian B
Subjects: Rare Diseases, Digestive Diseases, Lung, Vector-Borne Diseases, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Animals, CD4-Positive T-Lymphocytes, Disease Models, Animal, Female, Hypertension, Pulmonary, Mice, Mice, Inbred C57BL, Pneumonia, Schistosomiasis, Th2 Cells, CD4 T cell, pulmonary hypertension, schistosomiasis, type 2 immunity, Cardiorespiratory Medicine and Haematology
Abstract: Background Inflammation underlies many forms of pulmonary hypertension (PH), including that resulting from Schistosoma infection, a major cause of PH worldwide. Schistosomiasis-associated PH is proximately triggered by embolization of parasite eggs into the lungs, resulting in localized type 2 inflammation. However, the role of CD4+ T cells in this disease is not well defined. Methods and Results We used a mouse model of schistosomiasis-associated PH, induced by intraperitoneal egg sensitization followed by intravenous egg challenge, with outcomes including right ventricle systolic pressure measured by cardiac catheterization, and cell density and phenotype assessed by flow cytometry. We identified that embolization of Schistosoma eggs into lungs of egg-sensitized mice increased the perivascular density of T-helper 2 (Th2) CD4+ T cells by recruitment of cells from the circulation and triggered type 2 inflammation. Parabiosis confirmed that egg embolization is required for localized type 2 immunity. We found Th2 CD4+ T cells were necessary for Schistosoma-induced PH, given that deletion of CD4+ T cells or inhibiting their Th2 function protected against type 2 inflammation and PH following Schistosoma exposure. We also observed that adoptive transfer of Schistosoma-sensitized CD4+ Th2 cells was sufficient to drive type 2 inflammation and PH. Conclusions Th2 CD4+ T cells are a necessary and sufficient component for the type 2 inflammation-induced PH following Schistosoma exposure.
Published: 2019

28. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Author: Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, 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U, Çakici, Mehmet Çağlar, Iplikci, Ayberk, Yildirim, Asif, Ozgur, Ilker, Sen, Comert, Dincer, Muserref B, Erginöz, Ergin, Sanli, Ahmet Necati, Turna, Akif, Askar, Ahmet, Uludağ, Server Sezgin, Guldogan, Cem E, Ozmen, Mehmet M, Bozkurt, Mehmet A, özcan, Adem, Kara, Yasin, Kocataş, Ali, Guner, Ali, Sari, Ramazan, Memisoglu, Ecem, Saracoglu, Kemal T, Tosun, Yasin, Çetin, Kenan, Kalafat, Erkan, Taskiran, Cagatay, Vatansever, Dogan, Giray, Burak, Tatar, Ozan C, Köksal, Hande, Özkent, Mehmet Serkan, Ulutaş, Mehmet E, Hamarat, Mustafa B, Coskun, Bora, Abbasov, Aykhan, Altinsoy, Ezgi, Uprak, Tevfik Kivilcim, Saracoglu, Ayten, Ugurlu, M Umit, Kose, Emin, Ozgen, Utku, Sungurtekin, Ugur, Gonullu, Emre, Bayhan, Zulfu, Akin, Emrah, Mantoglu, Baris, Colak, Elif, Kucuk, Gultekin Ozan, Yuksel, Cemil, Aydin, Ferit, Dogan, Lutfi, Culcu, Serdar, Tufan, Aydin Eray, Citgez, Bulent, Akpinar, Göksever, Köksoy, Ülkü C, Ulgur, Hanife Seyda, Kalin, Murat, Ozkan, Omer Faruk, Yildirak, Muhammed Kadir, Atici, Semra Demirli, Salimoğlu, Semra, Abud, Burcin, Calik, Bulent, Kamer, Erdinc, Kebabci, Eyup, Uylas, Ufuk, Teker, Kenan, Cakmak, Guldeniz Karadeniz, Gultekin, Fatma Ayca, Xaviour, Okedi Francis, Isaac, Otolia, Gaston, Turinawe, Asiimwe, Daniel, Vahwere, Bienfait Mumbere, Sikakulya, Franck Katembo, Lule, Herman, Lugobe, Henry Mark, Lekuya, Hervé Monka, Namugenyi, Christine, Kiweewa, Ronald, Bosco, Muhangi, Yovenko, Ihor, Kopetskyi, Viacheslav, Maksymenko, Bogdan, Khan, Sabina A, Padvi, Amit Vasantrao, Serour, Mohamed A, Beigh, Shamim Ahmad, Elsayed, Hisham M, Mohamed, Awadelkarim O, Basappanavar, Vikram Somashekhar, Al-Wandi, Amna S, Khalil, Kareem S, Younis, Muhammad Umar, Al Saadi, Hayder S Abdulhadi, Heidan, Ginan K, Trehan, Ravi K, Davies, Justin, Ashcroft, James, Georgiades, Fanourios, Durrani, Amer J, Price, Stephen J, Wong, Kai Yuen, Agrawal, Amit, Seah, Matthew KT, Saad, Marwa M E, Segaren, Nicholas, Ghobrial, Marios, Balakrishnan, Anita, Forouhi, Parto, Khan, Wasim S, Wheeler, James, Schache, Andrew G, Katsikostas, Dimitrios P, Angelou, Dimitrios, Fell, Adam J, Madani, Rana, Dindyal, Shiva, Seraj, Shaikh S, Sharavanan, Premalatha, Iqbal, Muhammad R, Wong, Nicholas J, Lo, William B, Soon, Wai C, Hammouche, Dalia, Lee, Jonathan DE, Pachl, Max J, Alexander, Dinesh, Ahmad, Shoaib, Morley, Hannah L, Selwyn, David, Wareing, Jonathan, Oktseloglou, Vlasios, Bobak, Peter, Rampersad, Lisa S, Mohamed, Mazin, Kaur, Mandeep, Athanasiou, Antonios, Martin, Benjamin P, Jichi, Tarik S, Batchelor, Tim JP, Rozwadowski, Sophie, Maniarasu, Sarveen, Seyed-Safi, Parisah K, Kutuzov, Vladislav, Shah, Hemina B, Noton, Toby M, Dela Cruz, Nina Jyne Minette, Trehan, Neev, Tokidis, Evripidis, Byrne, Matthew H V, Winter, Stuart C, Pinto-Lopes, Rui, Pavithran, Aswathy, Khalifa, Ahmad O, Eardley, Nicola J, Ashour, Rami, Steinke, Jacqueline D, Esmail, Husayn D, Bence, Matthew N, Walters, Samuel T, Akinyemi, Tosin O, Lakpriya, Sathya, Moawad, Nader N, Panahi, Pedram, Lau, Joshua, McAleer, Stephen, Laoye, Adeyinka, Hussain, Abdulzahra Abdulsamad, Zafar, Muneeb, Elsheikh, Mohammed H, Shaerf, Daniel A, Soggiu, Fiammetta, Massoumi, Abaris, Gareb, Fahed, Yao, Mark W, Qamar, Mubasher A, Fang, Clarissa E H, Greenhalgh, Michael S, Hunt, Alexander, Oladeji, Emmanuel O, Benjamin, Miles W, Beak, Philip, Rae, Fraser J, Aithie, Joanna M S, Clarke, Gareth W J, Veeramootoo, Darmarajah, Ashman, Alex J, Kahka, Ehab E, Rafe, Tanvir, PATEL, PANNA K, Albirnawi, Hatim, Katory, Mark, Fisher, Ann, Amonkar, Sunil J, Rao, Pawan Kumar Dhruva, Holroyd, David J, Gkikas, Andreas, Newton, Lydia S, Kirk, Alan J B, Khalid, Ayesha, Ferguson, David, Stanier, Paul B, Shah, Vinay, El-Boghdadly, Kariem, Schizas, Alexis M P, ilyas, Minahi, George, Mark L, Gawad, Mothana, Groom, William D, Al-Azzawi, Mohammed, Ahluwalia, Julian CJ, Punjabi, Prakash P, Cheung, Fang Yi, Wilson, Michael D, Mitrofan, Claudia Gabriela, Malam, Yogeshkumar, Townson, Adam, Loubani, Mahmoud, Yau, Jih Dar, Seebah, Kevin, Akowuah, Enoch F, Pushpoth, Sreekumari R, Viswanath, Yirupaiahgari KS, ElSanhoury, Kareem, Chew, Misha, Walker, Thomas E, Elhassan, Almutasim Billah Elbagir, Belcher, Elizabeth, Goricar, Matej, majd, Hooman Soleymani, Knight, Dominic, Ismail, Lamiese, McKinnon, Chris, Ganau, Mario, Prokopenko, Max, Doshi, Neel S, Gkorila, Aikaterina, Sheikh, Nomaan A, Helm, Jessica R, Low, Mei Ken, Ogunfusika, Oluseyi Harold, Bisheet, George, Alhammali, Tariq, Arnob, Ahmed Showki, Singh, Jatinder, Allde, Emma L, Sambhwani, Sharan H, Dube, Manas, Gemmill, Elizabeth H, John, Joby, Gerogiannis, Ioannis N, Abuelgasim, Mona A A, Crate, Georgina, Holme, Thomas J, Nguyen, Anh T V, Ho, Michael W, Wade, Ryckie G, Hussain, Azar, Andrzejowski, Paul, Omakobia, Eugene, Eltayeb, Momin, Galabov, Tsanko P, Lee, Chung Yan Vernon, Nazir, Anum, Siaw, Oliver L, Ashford, Robert U, Boddy, Alex P, Ashmore, Christopher D, Shah, Snehadhar M, Gowers, Benjamin T V, Thekkinkattil, Dinesh K, Worku, Dawit, Harky, Amer, Talwar, Rishi, Sagoo, Harkiran K, Jambulingam, Periyathambi S, Smart, Christopher J, Doherty, Daniel T, Mastoridis, Sotiris, Kumar, Sidharth, Mahmoud, Rana, Solari, Francesca, Egan, Richard J, Barry, Jonathan D, Morrison, Jo, Davoudi, Kaveh, Hollyman, Marianne, Kelly, Andrew, Badenoch, Thomas F, pandanaboyana, sanjay, Critchley, Rebecca J, Sarodaya, Varun R, Sinnerton, Robert J H, Manickavasagam, Jaiganesh, Lindsay, Elizabeth F, Arora, Ankita, Hasan, Raashad, Liew, Ignatius, Ozua, Joshua, Kouritas, Vasileios, Collins, Rachael V, Lafford, George H, Moret, Charlie, Chean, Chung Shen, Horgan, Liam F, Aujayeb, Avinash, Siddique, Muhammad Harris, Navaratne, Lalin, Kotecha, Sanjeev, Bellato, Vittoria, Lewis, Sophia E, Ali, Muhammad Usman, Marson, Ben A, Craxford, Simon, Gajjar, Ketankumar, Theophilidou, Elena, Aboelmagd, Tariq, Khatkar, Harman, Awadallah, Mahmoud A, Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
Published: 2022
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29. Factores clínicos asociados a tumores neuroendocrinos en pacientes ecuatorianos: un análisis biplot logístico

Author: Montes Escobar, Karime, Vicente Villardón, José Luis, Alarcón Cano, Daniel Fabricio, and Siteneski, Aline
Published: 2022
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30. Protocolo para diafanización dental

Author: Arango Cano, Daniel, Santacruz Quiroga, Jhonathan, Zamora Córdoba, Ingrid Ximena, and Alfonso Morales, Gilbert
Published: 2023
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31. The Impact of a Multicultural Exchange between Indigenous and Non-Indigenous History Teachers for Students' Attitudes: Preliminary Evidence from a Pilot Study in Chile

Author: Figueiredo, Ana, Madero, Cristobal, and Cano, Daniel
Abstract: This manuscript presents the results of a pilot study, Kuykuitin. A project that provides history teachers of elite schools in Chile with firsthand contact with history teachers in an intercultural school in the Araucanía. This region is the conflict zone with higher levels of violence between the Mapuche and the Chilean State. The pilot study analyzes the perceptions of the students of elite schools in the city's capital -- Santiago -- about the Mapuche and the present-day conflict, before and after their history teachers participated in the Kuykuitin project.
Published: 2020
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32. An improved Halo Occupation Distribution prescription from UNITsim Hα Emission Line Galaxies: Conformity and modified radial profile

Author: Reyes-Peraza, Guillermo, primary, Avila, Santiago, additional, Gonzalez-Perez, Violeta, additional, Lopez-Cano, Daniel, additional, Knebe, Alexander, additional, Ramakrishnan, Sujatha, additional, and Yepes, Gustavo, additional
Published: 2024
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33. Validation of the network method for evaluating uncertainty and improvement of geometry error parameters of a laser tracker

Author: Icasio-Hernández, Octavio, Bellelli, Diego Aldo, Brum Vieira, Luiz H., Cano, Daniel, and Muralikrishnan, Bala
Published: 2021
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34. Multiatom Greenberger-Horne-Zeilinger states using cavity-induced Rydberg blockade

Author: Cano, Daniel, Fortágh, József, Fernandez, Veronica, and Miranda, Rodolfo
Subjects: Quantum Physics
Abstract: We describe a novel method for producing Greenberger-Horne-Zeilinger states in cold atoms coupled to a superconducting coplanar cavity. In the proposed scheme, atoms interact between each other by virtual photon exchange via a cavity mode. These interactions cause an asymmetric Rydberg blockade mechanism that suppresses simultaneous excitations into different atomic Rydberg levels, thus forcing all atoms to occupy the same Rydberg state. This mechanism has effect even if the atoms are separated by distances of the order of millimeters. The atomic populations are transferred adiabatically from the ground state into the entangled state by following a collective dark state with low dissipation rates., Comment: 6 pages, 4 figures
Published: 2016

35. Nódulos subcutáneos faciales de 3 meses de evolución

Author: Martinez-Lopez, Antonio, Pérez-Lopez, Israel, Sánchez-Cano, Daniel, and Ruiz-Villaverde, Ricardo
Subjects: dermal fillers, silicone filler, sonography, ultrasonography, panniculitis
Abstract: Siliconomas are subcutaneous nodules that usuallyappear as a consequence of the migration of freesilicon implanted in other locations. They are morefrequent in women with abnormal breast implants,such as poly implant prostheses (PIP), but they may alsoappear after illegal injection of free silicone. We reporta 57-year-old woman who attended our Dermatologyclinic complaining of relapsing facial panniculitis ofunknown origin. After a thorough work-up, thesenodules were determined to be the consequence ofdermal filler made with fluid silicone, which had beeninjected 20 years prior. High frequency skin ultrasoundof one of the nodules showed a hyperechoic image,also known as “snowstorm,” which was located in thesubcutaneous tissue. The disposition of silicone in thisplane obscures the view of any sonographic structurein the underlying plane. Cutaneous sonographyhas become one of the most useful non-invasivetechniques in diagnosis of filler complications andother inflammatory diseases. Combined treatmentwith prednisone and allopurinol was successful, withno recurrence after 1 year of follow-up.
Published: 2017

36. Telerehabilitation in Colombia: A Country Report and Qualitative Analysis During the Covid-19 Pandemic - Perceptions of Healthcare Providers and Patients

Author: Pacichana-Quinayaz, Sara Gabriela, Rodríguez Vélez, Lina María, Sánchez Cano, Daniel, León-Sánchez, Yisel Mabirlly, Hernández-Orobio, Olga Marina, Tovar-Sánchez, Maria Ana, Toro Córdoba, Gloria Isabel, Bonilla-Escobar, Francisco Javier, Pacichana-Quinayaz, Sara Gabriela, Rodríguez Vélez, Lina María, Sánchez Cano, Daniel, León-Sánchez, Yisel Mabirlly, Hernández-Orobio, Olga Marina, Tovar-Sánchez, Maria Ana, Toro Córdoba, Gloria Isabel, and Bonilla-Escobar, Francisco Javier
Abstract: Given Colombia’s status as a middle-income country with healthcare challenges, leveraging telemedicine could significantly benefit hard-to-reach regions, under-resourced and underserved communities. This study provides a comprehensive overview of the country's telerehabilitation landscape, exploring the clinicians' and patients' perspectives during the COVID-19 pandemic through systematic review and qualitative analysis. Sixteen therapists and three patients were identified via snowball sampling. The literature review was scarce and scattered across various topics in the country; some studies delved into specific aspects like legislative frameworks and patient outcomes from different medical specialties. The qualitative analysis demonstrates that despite the learning curve, telerehabilitation strengthens therapeutic support, enhances patient autonomy, fosters a positive patient-provider relationship, achieves treatment goals, promotes family involvement, reduces time and costs, and ensures continuity of therapy services. This study identified research gaps, challenges, and opportunities in telerehabilitation in a Latin American country. Adopting telemedicine technologies in low- and middle-income countries could significantly enhance their healthcare systems.
Published: 2024

37. Different patterns of pulmonary vascular disease induced by type 1 diabetes and moderate hypoxia in rats

Author: Moral Sanz, Javier, Lopez Lopez, José G., Menendez, Carmen, Moreno González, Enrique, Barreira, Bianca, Morales Cano, Daniel, Escolano, Lucia, Fernandez Segoviano, Pilar, Villamor, Eduardo, Cogolludo, Angel, Perez Vizcaino, Francisco, Moreno Gutiérrez, Laura, Moral Sanz, Javier, Lopez Lopez, José G., Menendez, Carmen, Moreno González, Enrique, Barreira, Bianca, Morales Cano, Daniel, Escolano, Lucia, Fernandez Segoviano, Pilar, Villamor, Eduardo, Cogolludo, Angel, Perez Vizcaino, Francisco, and Moreno Gutiérrez, Laura
Abstract: Although type 1 and type 2 diabetes are strongly associated with systemic cardiovascular morbidity, the relationship with pulmonary vascular disease had been almost disregarded until recent epidemiological data revealed that diabetes might be a risk factor for pulmonary hypertension. Recent experimental studies suggest that diabetes induces changes in lung function insufficient to elevate pulmonary pressure. The aim of this study was to assess the effects of diabetes on the sensitivity to other risk factors for pulmonary hypertension. We therefore analysed the effects of the combination of diabetes with exposure to moderate hypoxia on classical markers of pulmonary hypertension. Control (saline-treated) and diabetic (70 mg kg-1 streptozotocin-treated) male Wistar-Kyoto rats were followed for 4 weeks and exposed to normoxia or moderate normobaric hypoxia (14%) for another 2 weeks. Hypoxia, but not diabetes, strongly reduced voltage-gated potassium currents, whereas diabetes, but not hypoxia, induced pulmonary artery endothelial dysfunction. Both factors independently induced pulmonary vascular remodelling and downregulated the lung bone morphogenetic protein receptor type 2. However, diabetes, but not hypoxia, induced pulmonary infiltration of macrophages, which was markedly increased when both factors were combined. Diabetes plus hypoxia induced a modest increase in diastolic and mean pulmonary artery pressure and right ventricular weight, while each of the two factors alone had no significant effect. The pattern of changes in markers of pulmonary hypertension was different for moderate hypoxia and diabetes, with no synergic effect except for macrophage recruitment, and the combination of both factors was required to induce a moderate elevation in pulmonary arterial pressure., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

38. HIV transgene expression impairs K+ channel function in the pulmonary vasculature

Author: Mondejar Parreño, Gema, Morales Cano, Daniel, Barreira, Bianca, Callejo, Maria, Ruiz-Cabello Osuna, Jesús, Moreno Gutiérrez, Laura, Esquivel Ruiz, Sergio Antonio, Mathie, Alistair, Butrous, Ghazwan, Pérez Vizcaíno, Francisco, Cogolludo Torralba, Ángel Luis, Mondejar Parreño, Gema, Morales Cano, Daniel, Barreira, Bianca, Callejo, Maria, Ruiz-Cabello Osuna, Jesús, Moreno Gutiérrez, Laura, Esquivel Ruiz, Sergio Antonio, Mathie, Alistair, Butrous, Ghazwan, Pérez Vizcaíno, Francisco, and Cogolludo Torralba, Ángel Luis
Abstract: Human immunodeficiency virus (HIV) infection is an established risk factor for pulmonary arterial hypertension (PAH); however, the pathogenesis of HIV-related PAH remains unclear. Since K+ channel dysfunction is a common marker in most forms of PAH, our aim was to analyze whether the expression of HIV proteins is associated with impairment of K+ channel function in the pulmonary vascular bed. HIV transgenic mice (Tg26) expressing seven of the nine HIV viral proteins and wild-type (WT) mice were used. Hemodynamic assessment was performed by echocardiography and catheterization. Vascular reactivity was studied in endothelium-intact pulmonary arteries. K+ currents were recorded in freshly isolated pulmonary artery smooth muscle cells (PASMC) using the patch-clamp technique. Gene expression was assessed using quantitative RT-PCR. PASMC from Tg26 mice had reduced K+ currents and were more depolarized than those from WT. Whereas voltage-gated K+ channel 1.5 (Kv1.5) currents were preserved, pH-sensitive noninactivating background currents (IKN) were nearly abolished in PASMC from Tg26 mice. Tg26 mice had reduced lung expression of Kv7.1 and Kv7.4 channels and decreased responses to the Kv7.1 channel activator L-364,373 assessed by vascular reactivity and patch-clamp experimental approaches. Although we found pulmonary vascular remodeling and endothelial dysfunction in Tg26 mice, this was not accompanied by changes in hemodynamic parameters. In conclusion, the expression of HIV proteins in vivo impairs pH-sensitive IKN and Kv7 currents. This negative impact of HIV proteins in K+ channels was not sufficient to induce PAH, at least in mice, but may play a permissive or accessory role in the pathophysiology of HIV-associated PAH., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

39. Ceramide Mediates Acute Oxygen Sensing in Vascular Tissues

Author: Moreno Gutiérrez, Laura, Moral Sanz, Javier, Morales Cano, Daniel, Barreira, Bianca, Moreno, Enrique, Ferrarini, Alessia, Pandolfi, Rachele, Ruperez, Francisco J., Cortijo, Julio, Sánchez Luna, Manuel Ramón, Villamor, Eduardo, Pérez Vizcaíno, Francisco, Cogolludo Torralba, Ángel Luis, Moreno Gutiérrez, Laura, Moral Sanz, Javier, Morales Cano, Daniel, Barreira, Bianca, Moreno, Enrique, Ferrarini, Alessia, Pandolfi, Rachele, Ruperez, Francisco J., Cortijo, Julio, Sánchez Luna, Manuel Ramón, Villamor, Eduardo, Pérez Vizcaíno, Francisco, and Cogolludo Torralba, Ángel Luis
Abstract: Aims: A variety of vessels, such as resistance pulmonary arteries (PA) and fetoplacental arteries and the ductus arteriosus (DA) are specialized in sensing and responding to changes in oxygen tension. Despite opposite stimuli, normoxic DA contraction and hypoxic fetoplacental and PA vasoconstriction share some mechanistic features. Activation of neutral sphingomyelinase (nSMase) and subsequent ceramide production has been involved in hypoxic pulmonary vasoconstriction (HPV). Herein we aimed to study the possible role of nSMase-derived ceramide as a common factor in the acute oxygen-sensing function of specialized vascular tissues. Results: The nSMase inhibitor GW4869 and an anticeramide antibody reduced the hypoxic vasoconstriction in chicken PA and chorioallantoic arteries (CA) and the normoxic contraction of chicken DA. Incubation with interference RNA targeted to SMPD3 also inhibited HPV. Moreover, ceramide and reactive oxygen species production were increased by hypoxia in PA and by normoxia in DA. Either bacterial sphingomyelinase or ceramide mimicked the contractile responses of hypoxia in PA and CA and those of normoxia in the DA. Furthermore, ceramide inhibited voltage-gated potassium currents present in smooth muscle cells from PA and DA. Finally, the role of nSMase in acute oxygen sensing was also observed in human PA and DA. Innovation: These data provide evidence for the proposal that nSMase-derived ceramide is a critical player in acute oxygen-sensing in specialized vascular tissues. Conclusion: Our results indicate that an increase in ceramide generation is involved in the vasoconstrictor responses induced by two opposite stimuli, such as hypoxia (in PA and CA) and normoxia (in DA)., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

40. Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

Author: Morales Cano, Daniel, Barreira, Bianca, De Olaiz Navarro, Beatriz, Callejo Arranz, María, Mondejar Parreño, Gema, Esquivel Ruiz, Sergio Antonio, Lorente, José Ángel, Moreno Gutiérrez, Laura, Barberá, Joan Albert, Cogolludo Torralba, Ángel Luis, Pérez Vizcaíno, Francisco, Morales Cano, Daniel, Barreira, Bianca, De Olaiz Navarro, Beatriz, Callejo Arranz, María, Mondejar Parreño, Gema, Esquivel Ruiz, Sergio Antonio, Lorente, José Ángel, Moreno Gutiérrez, Laura, Barberá, Joan Albert, Cogolludo Torralba, Ángel Luis, and Pérez Vizcaíno, Francisco
Abstract: Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli, i.e., producing ventilation-perfusion mismatch, with detrimental effects on gas exchange. The aim of this study is to analyze the oxygen-sensitivity in vitro of 25 drugs currently used or potentially useful for PH. Additionally, the study analyses the effectiveness of these vasodilators in the pulmonary vs the systemic vessels. Vasodilator responses were recorded in pulmonary arteries (PA) and mesenteric arteries (MA) from rats and in human PA in a wire myograph under different oxygen concentrations. None of the studied drugs showed oxygen selectivity, being equally or more effective as vasodilators under conditions of low oxygen as compared to high oxygen levels. The drugs studied showed low pulmonary selectivity, being equally or more effective as vasodilators in systemic than in PA. A similar behavior was observed for the members within each drug family. In conclusion, none of the drugs showed optimal vasodilator profile, which may limit their therapeutic efficacy in PH., Ministerio de Economía, Comercio y Empresa, Instituto de Salud Carlos III, Unión Europea, Fundación contra la Hipertensión Pulmonar, Universidad Complutense de Madrid, Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

41. Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction

Author: Pandolfi, Rachele, Barreira, Bianca, Moreno, Enrique, Lara Acedo, Victor, Morales Cano, Daniel, Martínez Ramas, Andrea, Olaiz Navarro, Beatriz de, Herrero, Raquel, Lorente, Jose Angel, Cogolludo Torralba, Ángel Luis, Perez-Vizcaino, Francisco, Moreno Gutiérrez, Laura, Pandolfi, Rachele, Barreira, Bianca, Moreno, Enrique, Lara Acedo, Victor, Morales Cano, Daniel, Martínez Ramas, Andrea, Olaiz Navarro, Beatriz de, Herrero, Raquel, Lorente, Jose Angel, Cogolludo Torralba, Ángel Luis, Perez-Vizcaino, Francisco, and Moreno Gutiérrez, Laura
Abstract: Background Pulmonary hypertension (PH) is frequently observed in patients with acute respiratory distress syndrome (ARDS) and it is associated with an increased risk of mortality. Both acid sphingomyelinase (aSMase) activity and interleukin 6 (IL-6) levels are increased in patients with sepsis and correlate with worst outcomes, but their role in pulmonary vascular dysfunction pathogenesis has not yet been elucidated. Therefore, the aim of this study was to determine the potential contribution of aSMase and IL-6 in the pulmonary vascular dysfunction induced by lipopolysaccharide (LPS). Methods Rat or human pulmonary arteries (PAs) or their cultured smooth muscle cells (SMCs) were exposed to LPS, SMase or IL-6 in the absence or presence of a range of pharmacological inhibitors. The effects of aSMase inhibition in vivo with D609 on pulmonary arterial pressure and inflammation were assessed following intratracheal administration of LPS. Results LPS increased ceramide and IL-6 production in rat pulmonary artery smooth muscle cells (PASMCs) and inhibited pulmonary vasoconstriction induced by phenylephrine or hypoxia (HPV), induced endothelial dysfunction and potentiated the contractile responses to serotonin. Exogenous SMase and IL-6 mimicked the effects of LPS on endothelial dysfunction, HPV failure and hyperresponsiveness to serotonin in PA; whereas blockade of aSMase or IL-6 prevented LPS-induced effects. Finally, administration of the aSMase inhibitor D609 limited the development of endotoxin-induced PH and ventilation-perfusion mismatch. The protective effects of D609 were validated in isolated human PAs. Conclusions Our data indicate that aSMase and IL-6 are not simply biomarkers of poor outcomes but pathogenic mediators of pulmonary vascular dysfunction in ARDS secondary to Gram-negative infections., Instituto de Salud Carlos III, Ministro de Economía y comptetividad, Comisión Europea, Reintegración Europea Marie Curie, Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

42. Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching

Author: Vinicio A. de Jesus Perez, Chamorro, Virginia, Morales Cano, Daniel, Milara, Javier, Barreira, Bianca, Moreno Gutiérrez, Laura, Callejo, Maria, Mondejar Parreño, Gema, Esquivel Ruiz, Sergio Antonio, Cortijo, Julio, Cogolludo Torralba, Ángel Luis, Barberá, Joan A., Pérez Vizcaíno, Francisco, Vinicio A. de Jesus Perez, Chamorro, Virginia, Morales Cano, Daniel, Milara, Javier, Barreira, Bianca, Moreno Gutiérrez, Laura, Callejo, Maria, Mondejar Parreño, Gema, Esquivel Ruiz, Sergio Antonio, Cortijo, Julio, Cogolludo Torralba, Ángel Luis, Barberá, Joan A., and Pérez Vizcaíno, Francisco
Abstract: Introduction Current treatment with vasodilators for pulmonary hypertension associated with respiratory diseases is limited by their inhibitory effect on hypoxic pulmonary vasoconstriction (HPV) and uncoupling effects on ventilation-perfusion (V’/Q’). Hypoxia is also a well-known modulator of the nitric oxide (NO) pathway, and may therefore differentially affect the responses to phosphodiesterase 5 (PDE5) inhibitors and soluble guanylyl cyclase (sGC) stimulators. So far, the effects of the sGC stimulator riociguat on HPV have been poorly characterized. Materials and methods Contraction was recorded in pulmonary arteries (PA) in a wire myograph. Anesthetized rats were catheterized to record PA pressure. Ventilation and perfusion were analyzed by micro-CT-SPECT images in rats with pulmonary fibrosis induced by bleomycin. Results The PDE5 inhibitor sildenafil and the sGC stimulator riociguat similarly inhibited HPV in vitro and in vivo. Riociguat was more effective as vasodilator in isolated rat and human PA than sildenafil. Riociguat was ≈3-fold more potent under hypoxic conditions and it markedly inhibited HPV in vivo at a dose that barely affected the thromboxane A2 (TXA2) mimetic U46619-induced pressor responses. Pulmonary fibrosis was associated with V’/Q’ uncoupling and riociguat did not affect the V’/Q’ ratio. Conclusion PDE5 inhibitors and sGC stimulators show a different vasodilator profile. Riociguat was highly effective and potentiated by hypoxia in rat and human PA. In vivo, riociguat preferentially inhibited hypoxic than non-hypoxic vasoconstriction. However, it did not worsen V’/Q’ coupling in a rat model of pulmonary fibrosis., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

43. The Flavonoid Quercetin Reverses Pulmonary Hypertension in Rats

Author: Sudhiranjan Gupta, Morales Cano, Daniel, Menendez, Carmen, Moreno González, Enrique, Moral Sanz, Javier, Barreira, Bianca, Pandolfi, Rachele, Moreno Gutiérrez, Laura, Cogolludo Torralba, Ángel Luis, Pérez Vizcaíno, Francisco, Sudhiranjan Gupta, Morales Cano, Daniel, Menendez, Carmen, Moreno González, Enrique, Moral Sanz, Javier, Barreira, Bianca, Pandolfi, Rachele, Moreno Gutiérrez, Laura, Cogolludo Torralba, Ángel Luis, and Pérez Vizcaíno, Francisco
Abstract: Quercetin is a dietary flavonoid which exerts vasodilator, antiplatelet and antiproliferative effects and reduces blood pressure, oxidative status and end-organ damage in humans and animal models of systemic hypertension. We hypothesized that oral quercetin treatment might be protective in a rat model of pulmonary arterial hypertension. Three weeks after injection of monocrotaline, quercetin (10 mg/kg/d per os) or vehicle was administered for 10 days to adult Wistar rats. Quercetin significantly reduced mortality. In surviving animals, quercetin decreased pulmonary arterial pressure, right ventricular hypertrophy and muscularization of small pulmonary arteries. Classic biomarkers of pulmonary arterial hypertension such as the downregulated expression of lung BMPR2, Kv1.5, Kv2.1, upregulated survivin, endothelial dysfunction and hyperresponsiveness to 5-HT were unaffected by quercetin. Quercetin significantly restored the decrease in Kv currents, the upregulation of 5-HT2A receptors and reduced the Akt and S6 phosphorylation. In vitro, quercetin induced pulmonary artery vasodilator effects, inhibited pulmonary artery smooth muscle cell proliferation and induced apoptosis. In conclusion, quercetin is partially protective in this rat model of PAH. It delayed mortality by lowering PAP, RVH and vascular remodeling. Quercetin exerted effective vasodilator effects in isolated PA, inhibited cell proliferation and induced apoptosis in PASMCs. These effects were associated with decreased 5-HT2A receptor expression and Akt and S6 phosphorylation and partially restored Kv currents. Therefore, quercetin could be useful in the treatment of PAH., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

44. Fibrous Caps in Atherosclerosis Form by Notch-Dependent Mechanisms Common to Arterial Media Development

Author: Martos Rodríguez, Carlos J., Albarrán Juárez, Julián, Morales Cano, Daniel, Caballero, Ainoa, MacGrogan, Donal, Pompa, José Luis de la, Carramolino, Laura, Bentzon, Jacob F., Martos Rodríguez, Carlos J., Albarrán Juárez, Julián, Morales Cano, Daniel, Caballero, Ainoa, MacGrogan, Donal, Pompa, José Luis de la, Carramolino, Laura, and Bentzon, Jacob F.
Abstract: OBJECTIVE: Atheromatous fibrous caps are produced by smooth muscle cells (SMCs) that are recruited to the subendothelial space. We tested whether the recruitment mechanisms are the same as in embryonic artery development, which relies prominently on Notch signaling to form the subendothelial medial SMC layers. APPROACH AND RESULTS: Notch elements were expressed in regions of fibrous cap in human and mouse plaques. To assess the causal role of Notch signaling in cap formation, we studied atherosclerosis in mice where the Notch pathway was inactivated in SMCs by conditional knockout of the essential effector transcription factor RBPJ (recombination signal-binding protein for immunoglobulin kappa J region). The recruitment of cap SMCs was significantly reduced without major effects on plaque size. Lineage tracing revealed the accumulation of SMC-derived plaque cells in the cap region was unaltered but that Notch-defective cells failed to reacquire the SMC phenotype in the cap. Conversely, to analyze whether the loss of Notch signaling is required for SMC-derived cells to accumulate in atherogenesis, we studied atherosclerosis in mice with constitutive activation of Notch signaling in SMCs achieved by conditional expression of the Notch intracellular domain. Forced Notch signaling inhibited the ability of medial SMCs to contribute to plaque cells, including both cap SMCs and osteochondrogenic cells, and significantly reduced atherosclerosis development. CONCLUSIONS: Sequential loss and gain of Notch signaling is needed to build the cap SMC population. The shared mechanisms with embryonic arterial media assembly suggest that the cap forms as a neo-media that restores the connection between endothelium and subendothelial SMCs, transiently disrupted in early atherogenesis., Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

45. Functional Assembly of Kv7.1/Kv7.5 Channels With Emerging Properties on Vascular Muscle Physiology

Author: Oliveras, Anna, Roura Ferrer, Meritxell, Solé, Laura, Cruz, Alicia de la, Prieto, Angela, Etxebarria, Ainhoa, Manils, Joan, Morales Cano, Daniel, Condom, Enric, Soler, Concepció, Cogolludo Torralba, Ángel Luis, Valenzuela, Carmen, Villarroel, Alvaro, Comes, Núria, Felipe, Antonio, Oliveras, Anna, Roura Ferrer, Meritxell, Solé, Laura, Cruz, Alicia de la, Prieto, Angela, Etxebarria, Ainhoa, Manils, Joan, Morales Cano, Daniel, Condom, Enric, Soler, Concepció, Cogolludo Torralba, Ángel Luis, Valenzuela, Carmen, Villarroel, Alvaro, Comes, Núria, and Felipe, Antonio
Abstract: Objective—Voltage-dependent K+ (Kv) channels from the Kv7 family are expressed in blood vessels and contribute to cardiovascular physiology. Although Kv7 channel blockers trigger muscle contractions, Kv7 activators act as vasorelaxants. Kv7.1 and Kv7.5 are expressed in many vessels. Kv7.1 is under intense investigation because Kv7.1 blockers fail to modulate smooth muscle reactivity. In this study, we analyzed whether Kv7.1 and Kv7.5 may form functional heterotetrameric channels increasing the channel diversity in vascular smooth muscles. Approach and Results—Kv7.1 and Kv7.5 currents elicited in arterial myocytes, oocyte, and mammalian expression systems suggest the formation of heterotetrameric complexes. Kv7.1/Kv7.5 heteromers, exhibiting different pharmacological characteristics, participate in the arterial tone. Kv7.1/Kv7.5 associations were confirmed by coimmunoprecipitation, fluorescence resonance energy transfer, and fluorescence recovery after photobleaching experiments. Kv7.1/Kv7.5 heterotetramers were highly retained at the endoplasmic reticulum. Studies in HEK-293 cells, heart, brain, and smooth and skeletal muscles demonstrated that the predominant presence of Kv7.5 stimulates release of Kv7.1/Kv7.5 oligomers out of lipid raft microdomains. Electrophysiological studies supported that KCNE1 and KCNE3 regulatory subunits further increased the channel diversity. Finally, the analysis of rat isolated myocytes and human blood vessels demonstrated that Kv7.1 and Kv7.5 exhibited a differential expression, which may lead to channel diversity. Conclusions—Kv7.1 and Kv7.5 form heterotetrameric channels increasing the diversity of structures which fine-tune blood vessel reactivity. Because the lipid raft localization of ion channels is crucial for cardiovascular physiology, Kv7.1/Kv7.5 heteromers provide efficient spatial and temporal regulation of smooth muscle function. Our results shed light on the debate about the contribution of Kv7 channels to vasoconstrictio, Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

46. Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities

Author: Kenneth Stapleford, Kumar, Rahul, Cogolludo Torralba, Ángel Luis, Pérez Vizcaíno, Francisco, Morales Cano, Daniel, Dhillon, Navneet K., Kenneth Stapleford, Kumar, Rahul, Cogolludo Torralba, Ángel Luis, Pérez Vizcaíno, Francisco, Morales Cano, Daniel, and Dhillon, Navneet K.
Abstract: The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

47. Topography of immune cell infiltration in different stages of coronary atherosclerosis revealed by multiplex immunohistochemistry

Author: Cortenbach, Kimberley R.G., Morales Cano, Daniel, Meek, Jelena, Gorris, Mark A.J., Staal, Alexander H.J., Srinivas, Mangala, Vries, Jolanda de, Bentzon, Jacob Fog, Kimmenade, Roland Renier Jozef van, Cortenbach, Kimberley R.G., Morales Cano, Daniel, Meek, Jelena, Gorris, Mark A.J., Staal, Alexander H.J., Srinivas, Mangala, Vries, Jolanda de, Bentzon, Jacob Fog, and Kimmenade, Roland Renier Jozef van
Abstract: Background: Aim of this study was to investigate immune cells and subsets in different stages of human coronary artery disease with a novel multiplex immunohistochemistry (mIHC) technique. Methods: Human left anterior descending coronary artery specimens were analyzed: eccentric intimal thickening (N = 11), pathological intimal thickening (N = 10), fibroatheroma (N = 9), and fibrous plaque (N = 9). Eccentric intimal thickening was considered normal, and pathological intimal thickening, fibroatheroma, and fibrous plaque were considered diseased coronary arteries. Two mIHC panels, consisting of six and five primary antibodies, autofluoresence, and DAPI, were used to detect adaptive and innate immune cells. Via semi-automated analysis, (sub)types of immune cells in whole plaques and specific plaque regions were quantified. Results: Increased numbers of CD3+ T cells (P < 0.001), CD20+ B cells (P = 0.013), CD68+ macrophages (P = 0.003), CD15+ neutrophils (P = 0.017), and CD31+ endothelial cells (P = 0.024) were identified in intimas of diseased coronary arteries compared to normal. Subset analyses of T cells and macrophages showed that diseased coronary arteries contained an abundance of CD3+CD8- non-cytotoxic T cells and CD68+CD206- non-M2-like macrophages. Proportions of CD3+CD45RO+ memory T cells were similar to normal coronary arteries. Among pathological intimal thickening, fibroatheroma, and fibrous plaque, all immune cell numbers and subsets were similar. Conclusions: The type of immune response does not differ substantially between different stages of plaque development and may provide context for mechanistic research into immune cell function in atherosclerosis. We provide the first comprehensive map of immune cell subtypes across plaque types in coronary arteries demonstrating the potential of mIHC for vascular research., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

48. Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia

Author: Morales Cano, Daniel, Moreno Gutiérrez, Laura, Barreira, Bianca, Pandolfi, Rachele, Chamorro, Virginia, Jimenez, Rosario, Villamor, Eduardo, Duarte, Juan, Pérez Vizcaíno, Francisco, Cogolludo Torralba, Ángel Luis, Morales Cano, Daniel, Moreno Gutiérrez, Laura, Barreira, Bianca, Pandolfi, Rachele, Chamorro, Virginia, Jimenez, Rosario, Villamor, Eduardo, Duarte, Juan, Pérez Vizcaíno, Francisco, and Cogolludo Torralba, Ángel Luis
Abstract: Aims Voltage-gated potassium channels encoded by KCNQ genes (Kv7 channels) are emerging as important regulators of vascular tone. In this study, we analysed the contribution of Kv7 channels to the vasodilation induced by hypoxia and the cyclic AMP pathway in the coronary circulation. We also assessed their regional distribution and possible impairment by diabetes. Methods and results We examined the effects of Kv7 channel modulators on K+ currents and vascular reactivity in rat left and right coronary arteries (LCAs and RCAs, respectively). Currents from LCA were more sensitive to Kv7 channel inhibitors (XE991, linopirdine) and activators (flupirtine, retigabine) than those from RCA. Accordingly, LCAs were more sensitive than RCAs to the relaxation induced by Kv7 channel enhancers. Likewise, relaxation induced by the adenylyl cyclase activator forskolin and hypoxia, which were mediated through Kv7 channel activation, were greater in LCA than in RCA. KCNQ1 and KCNQ5 expression was markedly higher in LCA than in RCA. After incubation with high glucose (HG, 30 mmol/L), myocytes from LCA, but not from RCA, were more depolarized and showed reduced Kv7 currents. In HG-incubated LCA, the effects of Kv7 channel modulators and forskolin were diminished, and the expression of KCNQ1 and KCNQ5 was reduced. Finally, vascular responses induced by Kv7 channel modulators were impaired in LCA, but not in RCA, from type 1 diabetic rats. Conclusion Our results reveal that the high expression and function of Kv7 channels in the LCA and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

49. Novel Loss-of-Function KCNA5 Variants in Pulmonary Arterial Hypertension

Author: Vera Zambrano, Alba, Morales Cano, Daniel, Villegas Esguevillas, Marta, Cruz Utrilla, Alejandro, Fernández Malavé, Edgar Gonzalo, Escribano Subías, María Pilar, Pérez Vizcaíno, Francisco, Cogolludo Torralba, Ángel Luis, Vera Zambrano, Alba, Morales Cano, Daniel, Villegas Esguevillas, Marta, Cruz Utrilla, Alejandro, Fernández Malavé, Edgar Gonzalo, Escribano Subías, María Pilar, Pérez Vizcaíno, Francisco, and Cogolludo Torralba, Ángel Luis
Abstract: Reduced expression and/or activity of Kv1.5 channels (encoded byKCNA5) is a common hallmark in human or experimentalpulmonary arterial hypertension (PAH). Likewise, genetic variantsinKCNA5have been found in patients with PAH, but theirfunctional consequences and potential impact on the disease arelargely unknown. Herein, this study aimed to characterize thefunctional consequences of sevenKCNA5variants found in a cohortof patients with PAH. Potassium currents were recorded by patch-clamp technique in HEK293 cells transfected with wild-type ormutant Kv1.5 cDNA. Flow cytometry, Western blot, and confocalmicroscopy techniques were used for measuring protein expressionand cell apoptosis in HEK293 and human pulmonary artery smoothmuscle cells.KCNA5variants (namely, Arg184Pro and Gly384Arg)found in patients with PAH resulted in a clear loss of potassiumchannel function as assessed by electrophysiological and molecular modeling analyses. The Arg184Pro variant also resulted in apronounced reduction of Kv1.5 expression. Transfection withArg184Pro or Gly384Arg variants decreased apoptosis ofhuman pulmonary artery smooth muscle cells compared withthe wild-type cells, demonstrating thatKCNA5dysfunction inboth variants affects cell viability. Thus, in addition toaffecting channel activity, both variants were associated withimpaired apoptosis, a crucial process linked to the disease. Theestimated prevalence of dysfunctionalKCNA5variants in thePAH population analyzed was around 1%. The data indicatethat someKCNA5variants found in patients with PAH havecritical consequences for channel function, supporting the ideathatKCNA5pathogenic variants may be a causative orcontributing factor for PAH., Unión Europea, Federación Española de Enfermedades Raras, Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

50. Elevated pulmonary arterial pressure in Zucker diabetic fatty rats

Author: Bader, Michael, Morales Cano, Daniel, Callejo Arranz, María, Barreira, Bianca, Mondejar Parreño, Gema, Esquivel Ruiz, Sergio Antonio, Ramos, Sonia, Martín Arribas, María Ángeles, Cogolludo, Angel, Moreno Gutiérrez, Laura, Pérez Vizcaíno, Francisco, Bader, Michael, Morales Cano, Daniel, Callejo Arranz, María, Barreira, Bianca, Mondejar Parreño, Gema, Esquivel Ruiz, Sergio Antonio, Ramos, Sonia, Martín Arribas, María Ángeles, Cogolludo, Angel, Moreno Gutiérrez, Laura, and Pérez Vizcaíno, Francisco
Abstract: Diabetes is a very strong predictor of chronic systemic vascular diseases and acute cardiovascular events. Recently, associations between metabolic disorders and pulmonary hypertension have also been reported in both humans and animal models. In order to get some further insight into the relationship of pulmonary hypertension with obesity, insulin resistance and hyperglycemia, herein we have used the Zucker diabetic fatty rats (ZDF/clr-lepr fa) at 20 weeks fed a standard diet and compared to their lean Zucker littermates (ZL). ZDF rats were obese, had elevated plasma glucose levels and insulin resistance, i.e. a clinically relevant model of type 2 diabetes. They presented elevated systolic, diastolic and mean pulmonary arterial pressures and a parallel increase in the Fulton index. Systemic arterial pressures were also increased but the left ventricle plus septum weight was similar in both groups and the heart rate was reduced. Wall media thickening was observed in the small pulmonary arteries from the ZDF rats. Isolated pulmonary arteries mounted in a wire myograph showed similar vasoconstrictor responses to phenylephrine and 5-HT and similar responses to the endothelium-dependent vasodilator acetylcholine. However, the iNOS inhibitor 1400W enhanced the vasoconstrictor responses in ZDF but not in ZL rats. The protein expression of eNOS and iNOS was not significantly different in the lungs of the two groups. The lung expression of Bmpr2 mRNA was downregulated. However, the mRNA expression of Kcna5, Kcnk3, Kcnq1, Kcnq4 or Kcnq5, which encode for the potassium channels Kv1.5, TASK-1, Kv7.1, Kv7.4 and Kv7.5, respectively, was similar in ZL and ZDF rats. In conclusion, ZDF rats show increased pulmonary arterial pressure, right ventricular hypertrophy, pulmonary arterial medial thickening and downregulated lung Bmpr2 despite leptin resistance. These changes were mild but are consistent with the view that diabetes is a risk factor for pulmonary hypertension., Unión Europea, Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub
Published: 2024

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