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9. Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women

Author

BROOKS-ASPLUND, E. M., CANNON, J. G., and KENNEY, W. L.

Subjects
Hormone therapy -- Physiological aspects, Aspirin -- Usage, Body temperature -- Regulation, Postmenopausal women -- Physiological aspects, Reproduction -- Endocrine aspects, Biological sciences
Abstract

Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women. Am J Physiol Regulatory Integrative Comp Physiol 279: R839-R848, 2000.--Postmenopausal women receiving estrogen-replacement therapy (ERT) regulate body temperature ([T.sub.b]) at a lower level than women not receiving hormone replacement therapy (untreated) and women using estrogen plus progesterone therapy (E + P), but it is not clear if reproductive hormones alter [T.sub.b] by directly acting on central thermoregulatory centers or indirectly via a secondary mediator(s). The purpose of the present investigation was to examine the possible involvement of pyrogenic cytokines and cyclooxygenase (COX) products (e.g., prostaglandins) in the regulation of [T.sub.b] in three groups of postmenopausal women (8 ERT, 7 E + P, and 8 untreated). We measured ex vivo secretion of cytokine agonists [tumor necrosis factor (TNF)-[Alpha] and interleukin (IL)-I[Beta] and -6] and modifiers (IL-2 soluble receptor, IL-1 receptor antagonist, soluble TNF receptor type I, soluble TNF receptor type II, soluble IL-6 receptor, and soluble glycoprotein 130) from peripheral blood mononuclear cells and thermoregulatory responses at rest and during 1 h of passive whole body heating in the postmenopausal women before and after 3 days of placebo or aspirin (50 mg[multiplied by]day-1 [multiplied by]kg-1). With and without aspirin, the ERT group had a lower baseline rectal temperature ([T.sub.re]; 0.44 [degrees] C, P [is less than] 0.004) and a reduced [T.sub.b] threshold for cutaneous vasodilation (0.29 [degrees] C and 0.38 [degrees] C, P [is less than] 0.01) compared with the untreated and E + P groups, respectively. In the placebo condition, waking morning oral temperature ([T.sub.or]) correlated with ex vivo secretion of the proteins associated with IL-6 bioactivity. Aspirin caused significant reductions in waking [T.sub.or] in the E + P group and in baseline [T.sub.re] in the untreated group. However, the difference in thermoregulation brought about by steroid hormone treatment could not be explained by these relatively modest apparent influences by cytokines and COX products. Therefore, the altered thermoregulation induced by reproductive steroid therapy appears to occur via a mechanism distinct from a classic infection-induced fever. skin blood flow; cytokines; cyclooxygenase; reproductive hormones; estrogen; progesterone

Published
2000

13. Locations of genetic markers on the physical map of the chromosome of Neisseria gonorrhoeae FA1090

Author

Cannon, J G and Dempsey, J A

Abstract

To increase the utility of the previously constructed physical map of the chromosome of Neisseria gonorrhoeae FA1090, 28 additional genetic markers were localized on the map. Cloned gonococcal genes were used to probe Southern blots of restriction enzyme-digested DNA separated on pulsed-field gels, thus identifying the fragment in each of several digests to which the probe hybridized and the map location of each gene. The addition of the new markers brings the total number of mapped loci for this strain to 68; the locations of all of those markers on the updated map are shown.

Published
1994
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17. Leptin, Blood Pressure, and Aerobic Capacity in Women

Author

Sabatier, M. J., primary, McCully, K. K., additional, Marinik, E. L., additional, Schwark, E. H., additional, Haddow, S., additional, Cortez-Cooper, M., additional, Bergeron, M. F., additional, Sloan, G. J., additional, and Cannon, J. G., additional

Published
2008
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50. Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever

Author

Cannon, J. G., primary, Tompkins, R. G., additional, Gelfand, J. A., additional, Michie, H. R., additional, Stanford, G. G., additional, van der Meer, J. W. M., additional, Endres, S., additional, Lonnemann, G., additional, Corsetti, J., additional, Chernow, B., additional, Wilmore, D. W., additional, Wolff, S. M., additional, Burke, J. F., additional, and Dinarello, C. A., additional

Published
1990
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