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Your search keyword '"Cannavo, G."' showing total 33 results
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33 results on '"Cannavo, G."'

1. The intertwining of healthcare-associated infections and COVID-19 in Italian intensive care units: an analysis of the SPIN-UTI project from 2006 to 2021

Author

Murgia, P., Masia, M.D., Mura, I., Brusaferro, S., Arnoldo, L., Di Stefano, C., Lucchese, F., Lugano, M., Tardivo, S., Moretti, F., Bernasconi, M.O., Pappalardo, F., Pasquarella, C., Sicoli, E., Montagna, M.T., Caggiano, G., De Giglio, O., Fenaroli, S., Squeri, R., Cannavò, G., Pulvirenti, A., Catalano, S., Mattaliano, A.R., Castiglione, G., Astuto, M., La Camera, G., Panascia, E., Longhitano, A.M., Scrofani, G., Gallea, M.R., Civello, P., Milazzo, M., Calamusa, G., Giarratano, A., Di Benedetto, A., Rizzo, G.M.G., Manta, G., Angelone, C., Mancuso, R., Tetamo, R., Mella, L.M., Dei, I., Pandiani, I., Cannistrà, A., Piotti, P., Girardis, M., Barbieri, A., Borracino, S., Palermo, R., Di Stefano, D., Colombo, A., Romeo, A., Minerva, M., Fabiani, L., Marinangeli, F., D’Errico, M.M., Donati, A., Domizi, R., Saglimbene, S.T., Bianco, A., Vittori, C., Orsi, G.B., Scibilia, M., Calà, O., Di Giacinto, I., Amatucci, M.R., Principi, T., Di Fabio, G., Gobbini, V., Olori, M.P., Antonelli, M., Laurenti, P., Condorelli, L., Ingala, F., Russo, S., Costa, P., Canonico, L., Farruggia, P., Cristina, M.L., Sartini, M., Arrigoni, C., Galassi, I., Vinci, V.M., Barchitta, M., Maugeri, A., Favara, G., Lio, R. Magnano San, La Rosa, M.C., D'Ancona, F., and Agodi, A.

Published
2023
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2. Vaccination coverage in healthcare workers: a multicenter cross-sectional study in Italy

Author

Genovese C., Picerno I. A. M., Trimarchi G., Cannavo G., Egitto G., Cosenza B., Merlina V., Icardi G., Panatto D., Amicizia D., Orsi A., Colosio C., Marsili C., Lari C., Palamara M. A. R., Vitale F., Casuccio A., Costantino C., Azara A., Castiglia P., Bianco A., Curra A., Gabutti G., Stefanati A., Sandri F., Florescu C., Marranzano M., Giorgianni G., Fiore V., Platania A., Torre I., Cappuccio A., Guillari A., Fabiani L., Giuliani A. R., Appetiti A., La Fauci V., Squeri A., Ragusa R., Squeri R., Genovese, C., Picerno, I. A. M., Trimarchi, G., Cannavo, G., Egitto, G., Cosenza, B., Merlina, V., Icardi, G., Panatto, D., Amicizia, D., Orsi, A., Colosio, C., Marsili, C., Lari, C., Palamara, M. A. R., Vitale, F., Casuccio, A., Costantino, C., Azara, A., Castiglia, P., Bianco, A., Curra, A., Gabutti, G., Stefanati, A., Sandri, F., Florescu, C., Marranzano, M., Giorgianni, G., Fiore, V., Platania, A., Torre, I., Cappuccio, Antonella, Guillari, A., Fabiani, L., Giuliani, A. R., Appetiti, A., La Fauci, V., Squeri, A., Ragusa, R., Squeri, R., Genovese C., Picerno I.A.M., Trimarchi G., Cannavo G., Egitto G., Cosenza B., Merlina V., Icardi G., Panatto D., Amicizia D., Orsi A., Colosio C., Marsili C., Lari C., Palamara M.A.R., Vitale F., Casuccio A., Costantino C., Azara A., Castiglia P., Bianco A., Curra A., Gabutti G., Stefanati A., Sandri F., Florescu C., Marranzano M., Giorgianni G., Fiore V., Platania A., Torre I., Cappuccio A., Guillari A., Fabiani L., Giuliani A.R., Appetiti A., La Fauci V., Squeri A., Ragusa R., and Squeri R.

Subjects
Adult, Male, 0303 health sciences, Vaccines, 030306 microbiology, Health Personnel, education, Nurses, Middle Aged, Infectious Disease Transmission, Professional-to-Patient, NO, 03 medical and health sciences, Healthcare workers, Vaccination coverage, Cross-Sectional Studies, Healthcare workers, Vaccination coverage, Vaccines, Italy, Physicians, Healthcare worker, Humans, Original Article, Female
Abstract

Introduction In recent years, a phenomenon known as "vaccine hesitancy" has spread throughout the world, even among health workers, determining a reduction in vaccination coverage (VC). A study aimed at evaluating VC among healthcare workers (HCWs) in 10 Italian cities (L'Aquila, Genoa, Milan, Palermo, Sassari, Catanzaro, Ferrara, Catania, Naples, Messina) was performed. Materials and methods Annex 3 of the Presidential Decree n. 445 of 28 December 2000 was used to collect information on the vaccination status of HCWs. The mean and standard deviation (SD) were calculated with regard to the quantitative variable (age), while absolute and relative frequencies were obtained for categorical data (sex, professional profile, working sector, vaccination status). The connection between VC and the categorical variables was evaluated by chi-square method (statistical significance at p, Journal of Preventive Medicine and Hygiene, Vol 60, No 1 (2019): 2019601

Published
2019

5. Il ruolo della cartella clinica ai fini della valutazione della qualità per l'accreditamento istituzionale

Author

VENTURA SPAGNOLO, Elvira, Cannavo' G, Ventura Spagnolo O, Panagia P, Cardia G., Ventura Spagnolo E, Cannavo' G, Ventura Spagnolo O, Panagia P, and Cardia G

Subjects
Settore MED/43 - Medicina Legale, quality, institutional accreditation, accreditamento istituzionale, cartella clinica, qualità, medical record
Abstract

The authors carried out research aimed at evaluating the quality of some aspects of a sample of medical records compiled in the operational uniti of a hospital. A subjective evaluation criterion was used, quantified by attibuting a correct numeric value by means of a weightingdeliberation factor. None of the medical record examined were judget qualitatively excellent. The main fact missing was the documentation regarding consensus, even in those medical records judget good or sufficient.

Published
2009

27. Immunology.

Author

Piedimonte, G., Corsi, D., Paiardini, M., Cannavo, G., Ientile, R., Picerno, I., Patki, A.H., Purvis, S.F., Valdez, H., Spritzler, J., Connick, E., Kuritzkes, D.R., Mezzaroma, I., Carlesimo, M., Pinter, E., Alario, C., Sacco, G., and Muratori, D. Santini

Abstract

Reports global developments related to AIDS immunology as of August 1999. Role of cell cycle regulation during HIV infection; Examination of DNA content of circulating lymphocytes obtained from HIV-1 infected persons; Differentiation of classic autoimmune thrombocytopenia with immune complex-associated thrombocytopenia in systemic lupus.

Published
1999

31. Involvement of 5-lipoxygenase in spinal cord injury

Author

Genovese, Tiziana, Mazzon, E, Rossi, A, DI PAOLA, R, Cannavo', Giuseppe, Muia, C, Crisafulli, Concetta, Bramanti, Placido, Sautebin, L, Cuzzocrea, Salvatore, DI PAOLA, Rosanna, Genovese, T., Mazzon, E., Rossi, Antonietta, DI PAOLA, R., Cannavo, G., Muia, C., Crisafulli, C., Bramanti, P., Sautebin, Lidia, and Cuzzocrea, S.

Subjects
medicine.medical_specialty, Pathology, Immunology, Apoptosis, Hindlimb, Severity of Illness Index, Mice, Animals, Immunology and Allergy, Medicine, Spinal cord injury, Spinal Cord Injuries, Mice, Knockout, Arachidonate 5-Lipoxygenase, biology, Tumor Necrosis Factor-alpha, business.industry, medicine.disease, Neutrophil Infiltration, Spinal Cord, Neurology, Arachidonate 5-lipoxygenase, biology.protein, Immunohistochemistry, Histopathology, Tumor necrosis factor alpha, Neurology (clinical), business, Infiltration (medical), Interleukin-1
Abstract

A traumatic spinal cord injury (SCI) induces a sequelae of events which conduce biochemical and cellular alterations. Here we compare the degree of spinal cord injury caused by the application of vascular clips, in mice lacking the 5-lipoxygenase and in the corresponding wild-type mice. Biochemical, immunohistochemical and functional studies revealed respectively an increase of neutrophils infiltration, of IL-1beta, TNF-alpha immunoreactivity, apoptosis (measured by Annexin-V staining) and loss of hind legs movement in SCI operated 5-LO wild-type mice. In contrast, the degree of (1) neutrophil infiltration at different time points, (2) cytokine expression (TNF-alpha and IL-1beta), (3) histological damage, (4) apoptosis, was markedly reduced in the tissues obtained from SCI operated 5-LO deficient mice and (5) the motor recovery was ameliorated.

Published
2005
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32. Abnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: A novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis

Author

Barbara Cervasi, Mauro Magnani, Giuseppe Piedimonte, Gionata De Vico, Denise Guetard, Isa Picerno, M. Paiardini, Giuseppe Cannavò, Maria L. Bocchino, Guido Silvestri, Domenico Galati, Maria Montroni, Cannavo, G, Paiardini, M, Galati, D, Cervasi, B, Montroni, M, DE VICO, Gionata, Guetard, D, Bocchino, Ml, Picerno, I, Magnani, M, Silvestri, G, and Piedimonte, G.

Subjects
Anti-HIV Agents, Lymphocyte, Immunology, Cyclin B, Apoptosis, Cell Cycle Proteins, HIV Infections, Biochemistry, Immune system, Cell Cycle Protein, medicine, Nucleolus Organizer Region, Humans, cdc25 Phosphatases, HIV Infection, Lymphocytes, Cyclin B1, Kinetic, Cyclin-dependent kinase 1, biology, Cell Cycle, Anti-HIV Agent, Apoptosi, Cell Biology, Hematology, T lymphocyte, Cell cycle, Phosphoproteins, Kinetics, medicine.anatomical_structure, Phosphoprotein, Cancer research, biology.protein, CDC28 Protein Kinase, S cerevisiae, Human
Abstract

Human immunodeficiency virus (HIV)-infection is characterized by loss of CD4+ T cells associated with high levels of immune activation, T-cell proliferation, and lymphocyte apoptosis. To investigate the role of intrinsic perturbations of cell-cycle control in the immunopathogenesis of acquired immunodeficiency syndrome (AIDS), we studied the expression of cell-cycle-dependent proteins in lymphocytes from HIV-infected patients. Cyclin B1 expression, Nucleolar Organizer Regions (NORs) number, and NORs area of distribution were all consistently increased in HIV-infected patients, but returned to normal after effective antiretroviral therapy, suggesting that viral replication is directly implicated in the genesis of the observed changes. Analysis of cyclin B1 intracellular turnover showed that the increased cyclin B1 expression is (1) caused by defective degradation in the presence of normal rates of synthesis, and (2) is temporally associated with decreased levels of ubiquitination. After in vitro activation of lymphocytes from healthy individuals, cyclin B1 and cdc25 expression and ubiquitination, p34 cdc2 activity, NORs morphology, and C23/nucleolin localization showed a 72- to 96-hour cyclic pattern that led to a biologic state similar to baseline. On the contrary, complex but consistent changes of the same indices followed activation of T lymphocytes from HIV-infected patients, resulting in a 5-fold increase in apoptosis. Overall, our data indicate that a profound dysregulation of cell-cycle control is present in lymphocytes from HIV-infected patients. This finding may provide a novel biologic link between immune activation, accelerated lymphocyte turnover, and increased apoptosis during HIV infection.

Published
2001

33. Exogenous interleukin-2 administration corrects the cell cycle perturbation of lymphocytes from human immunodeficiency virus-infected individuals.

Author

Paiardini M, Galati D, Cervasi B, Cannavo G, Galluzzi L, Montroni M, Guetard D, Magnani M, Piedimonte G, and Silvestri G

Subjects
Antiretroviral Therapy, Highly Active, Cell Nucleolus, Cysteine Endopeptidases biosynthesis, HIV Infections drug therapy, Humans, Interleukin-2 biosynthesis, Lymphocytes physiology, Multienzyme Complexes biosynthesis, Ornithine Decarboxylase biosynthesis, Proteasome Endopeptidase Complex, Cell Cycle drug effects, HIV Infections immunology, Interleukin-2 pharmacology, Lymphocytes drug effects
Abstract

Human immunodeficiency virus (HIV)-induced immunodeficiency is characterized by progressive loss of CD4(+) T cells associated with functional abnormalities of the surviving lymphocytes. Increased susceptibility to apoptosis and loss of proper cell cycle control can be observed in lymphocytes from HIV-infected individuals and may contribute to the lymphocyte dysfunction of AIDS patients. To better understand the relation between T-cell activation, apoptosis, and cell cycle perturbation, we studied the effect of exogenous interleukin-2 (IL-2) administration on the intracellular turnover of phase-dependent proteins. Circulating T cells from HIV-infected patients display a marked discrepancy between a metabolic profile typical of G(0) and a pattern of expression of phase-dependent proteins that indicates a more-advanced position within the cell cycle. This discrepancy is enhanced by in vitro activation with ConA and ultimately results in a marked increase of apoptotic events. Conversely, treatment of lymphocytes with IL-2 alone restores the phase-specific pattern of expression of cell cycle-dependent proteins and is associated with low levels of apoptosis. Interestingly, exogenous IL-2 administration normalizes the overall intracellular protein turnover, as measured by protein synthesis, half-life of newly synthesised proteins, and total protein ubiquitination, thus providing a possible explanation for the effect of IL-2 on the intracellular kinetics of cell cycle-dependent proteins. The beneficial effect of IL-2 administration is consistent with the possibility of defective IL-2 function in vivo, which is confirmed by the observation that lymphocytes from HIV-infected patients show abnormal endogenous IL-2 paracrine/autocrine function upon in vitro mitogen stimulation. Overall these results confirm that perturbation of cell cycle control contributes to HIV-related lymphocyte dysfunction and, by showing that IL-2 administration can revert this perturbation, suggest a new mechanism of action of IL-2 therapy in HIV-infected patients.

Published
2001
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