Search

Your search keyword '"Canino, Glorisa"' showing total 1,562 results
Start Over Author "Canino, Glorisa"

Refine your results

1,562 results on '"Canino, Glorisa"'

1. Prenatal sleep health and risk of offspring ADHD symptomatology and associated phenotypes: a prospective analysis of timing and sex differences in the ECHO cohort

Author

Lugo-Candelas, Claudia, Hwei, Tse, Lee, Seonjoo, Lucchini, Maristella, Aizza, Alice Smaniotto, Kahn, Linda G, Buss, Claudia, O'Connor, Thomas G, Ghassabian, Akhgar, Padula, Amy M, Aschner, Judy, Deoni, Sean, Margolis, Amy E, Canino, Glorisa, Monk, Catherine, Posner, Jonathan, and Duarte, Cristiane S

Subjects
Midwifery, Health Sciences, Psychology, Minority Health, Prevention, Attention Deficit Hyperactivity Disorder (ADHD), Pediatric, Clinical Research, Pregnancy, Women's Health, Neurosciences, Mental Health, Brain Disorders, Mental Illness, Sleep Research, Behavioral and Social Science, 2.3 Psychological, social and economic factors, Reproductive health and childbirth, Mental health, Good Health and Well Being, Prenatal sleep health, Offspring ADHD, Intergenerational transmission
Abstract

BackgroundSleep difficulties are common in pregnancy, yet poor prenatal sleep may be related to negative long-term outcomes for the offspring, including risk for attention-deficit/hyperactivity disorder (ADHD). Existing studies are few and have not examined timing of exposure effects or offspring sex moderation. We thus aimed to test the hypotheses that poor sleep health in pregnancy is associated with increased risk for ADHD symptoms and offspring sleep problems at approximately 4 years of age.MethodsParticipants were 794 mother-child dyads enrolled in the NIH Environmental Influences on Child Health Outcomes Study (ECHO). Participants self-reported on sleep duration, quality, and disturbances during pregnancy and on children's ADHD symptoms and sleep problems on the Child Behaviour Checklist.FindingsPregnant participants were 32.30 ± 5.50 years and children were 46% female. 44 percent of pregnant participants identified as Hispanic or Latine; 49% identified as White. Second-trimester sleep duration was associated with offspring ADHD symptoms (b = -0.35 [95% CI = -0.57, -0.13], p = 0.026), such that shorter duration was associated with greater symptomatology. Poorer sleep quality in the second trimester was also associated with increased ADHD symptomatology (b = 0.66 [95% CI = 0.18, 1.14], p = 0.037). Greater sleep disturbances in the first trimester were associated with offspring ADHD (b = 1.03 [95% CI = 0.32, 1.03], p = 0.037) and in the second trimester with sleep problems (b = 1.53 [95% CI = 0.42, 2.92], p = 0.026). We did not document substantial offspring sex moderation.InterpretationPoor prenatal sleep health, particularly quality and duration in the second trimester, may be associated with offspring risk of neurodevelopmental disorders and sleep problems in early childhood. Further research is needed to understand mechanisms, yet our study suggests that prenatal maternal sleep may be a modifiable target for interventions aimed at optimizing early neurodevelopment.FundingNIH grants U2COD023375, U24OD023382, U24OD023319, UH3OD023320, UH3OD023305, UH3OD023349, UH3OD023313, UH3OD023272, UH3OD023328, UH3OD023290, K08MH117452 and NARSAD Young Investigator Award 28545.

Published
2023

8. Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness

Author

Joo, Jaehyun, Mak, Angel CY, Xiao, Shujie, Sleiman, Patrick M, Hu, Donglei, Huntsman, Scott, Eng, Celeste, Kan, Mengyuan, Diwakar, Avantika R, Lasky-Su, Jessica A, Weiss, Scott T, Sordillo, Joanne E, Wu, Ann C, Cloutier, Michelle, Canino, Glorisa, Forno, Erick, Celedón, Juan C, Seibold, Max A, Hakonarson, Hakon, Williams, L Keoki, Burchard, Esteban G, and Himes, Blanca E

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Epidemiology, Health Sciences, Pharmacology and Pharmaceutical Sciences, Minority Health, Health Disparities, Precision Medicine, Pediatric, Prevention, Asthma, Human Genome, Lung, Clinical Research, Biotechnology, 2.1 Biological and endogenous factors, Respiratory, Good Health and Well Being, Axonemal Dyneins, Bronchodilator Agents, Child, Ethnicity, Genome-Wide Association Study, Hispanic or Latino, Humans, Mexican Americans, Minority Groups, Polymorphism, Single Nucleotide
Abstract

Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator response (BDR) to identify potential mechanisms of drug response and risk factors for worse asthma outcomes. Genome-wide association studies of bronchodilator response (BDR) were performed using TOPMed Whole Genome Sequencing data of the Asthma Translational Genomic Collaboration (ATGC), which corresponded to 1136 Puerto Rican, 656 Mexican and 4337 African American patients with asthma. With the population-specific GWAS results, a trans-ethnic meta-analysis was performed to identify BDR-associated variants shared across the three populations. Replication analysis was carried out in three pediatric asthma cohorts, including CAMP (Childhood Asthma Management Program; n = 560), GACRS (Genetics of Asthma in Costa Rica Study; n = 967) and HPR (Hartford-Puerto Rico; n = 417). A genome-wide significant locus (rs35661809; P = 3.61 × 10-8) in LINC02220, a non-coding RNA gene, was identified in Puerto Ricans. While this region was devoid of protein-coding genes, capture Hi-C data showed a distal interaction with the promoter of the DNAH5 gene in lung tissue. In replication analysis, the GACRS cohort yielded a nominal association (1-tailed P

Published
2022

11. The Other US Border: Health Insurance Coverage Among Latino Immigrants In Puerto Rico

Author

Rivera-González, Alexandra C, Stimpson, Jim P, Roby, Dylan H, Canino, Glorisa, Purtle, Jonathan, Bellamy, Scarlett L, and Ortega, Alexander N

Subjects
Human Society, Demography, Clinical Research, Basic Behavioral and Social Science, Behavioral and Social Science, Good Health and Well Being, Adolescent, Adult, Emigrants and Immigrants, Hispanic or Latino, Humans, Insurance Coverage, Insurance, Health, Medically Uninsured, Middle Aged, Puerto Rico, United States, Young Adult, Public Health and Health Services, Applied Economics, Health Policy & Services, Health services and systems, Policy and administration
Abstract

Puerto Rico is a US territory and a popular destination for Latino immigrants in the Caribbean. Even with few language and cultural barriers, however, many Latino immigrants in Puerto Rico are uninsured. Using data from the 2014-19 Puerto Rico Community Survey, we examined inequities in health insurance coverage for non-Puerto Rican Latinos ages 18-64 living in Puerto Rico according to citizenship status and Latino subgroup (Dominican, Cuban, Mexican, and other Latino). After controlling for potential confounders, we found that noncitizen Dominicans had a significantly lower probability of having any health insurance (57.2 percent) and having any private insurance (31.5 percent). Regardless of similarities in culture and language, Latino immigrants on the island, particularly Dominicans, experience major health insurance coverage inequities. Considering that Puerto Rico's immigration system is regulated by US federal statute, both federal and local policy makers should acknowledge and focus on reducing these immigrant disparities in health insurance coverage.

Published
2021

16. Growing inequities in mental health crisis services offered to indigent patients in Puerto Rico versus the US states before and after Hurricanes Maria and Irma

Author

Purtle, Jonathan, Rivera-Gonzalez, Alexandra C., Mercado, Damaris Lopez, Barajas, Clara B., Chavez, Ligia, Canino, Glorisa, and Ortega, Alexander N.

Subjects
Equality -- Health aspects -- Psychological aspects, Health care disparities -- Management, Psychiatric services -- Evaluation, Crisis intervention (Psychiatry) -- Management, Company business management, Business, Health care industry
Abstract

Objective: To assess changes in the availability of mental health crisis services in Puerto Rico relative to US states before and after Hurricanes Maria and Irma. Data Sources/Study Setting: National Mental Health Services Surveys conducted in 2016 and 2020. Study design: Repeated cross-sectional design. The independent variable was mental health facility location in Puerto Rico or a US state. Dependent variables were the availability of three mental health crisis services (psychiatric emergency walk-in services, suicide prevention services, and crisis intervention team services). Data Collection/Extraction Methods: The proportion and per 100,000 population rate of facilities offering crisis services were calculated. Principal Findings: The availability of crisis services at mental health facilities in Puerto Rico remained stable between 2016 and 2020. These services were offered less at indigent care facilities in Puerto Rico than US states (e.g., 38.2% vs. 49.5% for suicide prevention, p = 0.06) and the magnitude of difference increased following Hurricane Maria. Conclusions: There are disparities between Puerto Rico and US states in the availability of mental health crisis services for indigent patients. KEYWORDS health care disparities, health care organizations and systems, indigent care, mental health, psychiatry, uninsured/safety net providers, 1 | INTRODUCTION Puerto Rico is a US territory that has experienced a series of major disasters and public health emergencies in recent years. (1-3) Hurricanes Irma and Maria were [...]

Published
2023
Full Text
View/download PDF

19. Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

Author

Smith, P.B., Newby, K.L., Jacobson, L.P., Catellier, D.J., Gershon, R., Cella, D., Alshawabkeh, A., Aschner, J., Merhar, S., Ren, C., Reynolds, A., Keller, R., Pryhuber, G., Duncan, A., Lampland, A., Wadhawan, R., Wagner, C., Hudak, M., Mayock, D., Walshburn, L., Teitelbaum, S.L., Stroustrup, A., Trasande, L., Blair, C., Gatzke-Kopp, L., Swingler, M., Mansbach, J., Spergel, J., Puls, H., Stevenson, M., Bauer, C., Deoni, S., Duarte, C., Dunlop, A., Elliott, A., Croen, L., Bacharier, L., O’Connor, G., Kattan, M., Wood, R., Hershey, G., Ownby, D., Hertz-Picciotto, I., Hipwell, A., Karagas, M., Karr, C., Mason, A., Sathyanarayana, S., Lester, B., Carter, B., Neal, C., Smith, L., Helderman, J., Leve, L., Ganiban, J., Neiderhiser, J., Weiss, S., Zeiger, R., Tepper, R., Lyall, K., Landa, R., Ozonoff, S., Schmidt, R., Dager, S., Schultz, R., Piven, J., Volk, H., Vaidya, R., Obeid, R., Rollins, C., Bear, K., Pastyrnak, S., Lenski, M., Msall, M., Frazier, J., Washburn, L., Montgomery, A., Barone, C., McKane, P., Paneth, N., Elliott, M., Herbstman, J., Schantz, S., Porucznik, C., Silver, R., Conradt, E., Bosquet-Enlow, M., Huddleston, K., Bush, N., Nguyen, R., O'Connor, T., Samuels-Kalow, M., Miller, Rachel L., Schuh, Holly, Chandran, Aruna, Aris, Izzuddin M., Bendixsen, Casper, Blossom, Jeffrey, Breton, Carrie, Camargo, Carlos A., Jr., Canino, Glorisa, Carroll, Kecia N., Commodore, Sarah, Cordero, José F., Dabelea, Dana M., Ferrara, Assiamira, Fry, Rebecca C., Ganiban, Jody M., Gern, James E., Gilliland, Frank D., Gold, Diane R., Habre, Rima, Hare, Marion E., Harte, Robyn N., Hartert, Tina, Hasegawa, Kohei, Khurana Hershey, Gurjit K., Jackson, Daniel J., Joseph, Christine, Kerver, Jean M., Kim, Haejin, Litonjua, Augusto A., Marsit, Carmen J., McEvoy, Cindy, Mendonça, Eneida A., Moore, Paul E., Nkoy, Flory L., O’Connor, Thomas G., Oken, Emily, Ownby, Dennis, Perzanowski, Matthew, Rivera-Spoljaric, Katherine, Ryan, Patrick H., Singh, Anne Marie, Stanford, Joseph B., Wright, Rosalind J., Wright, Robert O., Zanobetti, Antonella, Zoratti, Edward, and Johnson, Christine C.

Published
2023
Full Text
View/download PDF

21. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Author

Kachroo, Priyadarshini, Hecker, Julian, Chawes, Bo L, Ahluwalia, Tarunveer S, Cho, Michael H, Qiao, Dandi, Kelly, Rachel S, Chu, Su H, Virkud, Yamini V, Huang, Mengna, Barnes, Kathleen C, Burchard, Esteban G, Eng, Celeste, Hu, Donglei, Celedón, Juan C, Daya, Michelle, Levin, Albert M, Gui, Hongsheng, Williams, L Keoki, Forno, Erick, Mak, Angel CY, Avila, Lydiana, Soto-Quiros, Manuel E, Cloutier, Michelle M, Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A, Lange, Christoph, Weiss, Scott T, Lasky-Su, Jessica A, National Heart, Lung, Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Allred, Nicholette Palmer, Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Barnard, John, Barnes, Kathleen, Barr, R Graham, Barron-Casella, Emily, Beaty, Terri, Becker, Diane, Becker, Lewis, Beer, Rebecca, Begum, Ferdouse, Beitelshees, Amber, Benjamin, Emelia, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Boerwinkle, Eric, Borecki, Ingrid, Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Bunting, Karen, Burchard, Esteban, Cardwell, Jonathan, Carty, Cara, Casaburi, Richard, Casella, James, Chaffin, Mark, Chang, Christy, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Chen, Yii-Der Ida, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, and Das, Sayantan

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Asthma, Genetics, Pediatric, Biotechnology, Human Genome, Lung, 2.1 Biological and endogenous factors, Respiratory, Adolescent, Adult, Cell Adhesion Molecules, Child, Child, Preschool, Costa Rica, Female, Forced Expiratory Volume, Humans, Interferon Regulatory Factors, Male, Middle Aged, Respiratory Physiological Phenomena, Vital Capacity, Whole Genome Sequencing, Young Adult, airway hyperresponsiveness, asthma, lung function, whole genome sequencing, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundAsthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function in individuals with a diagnosis of asthma.MethodsWGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based Genetic Epidemiology of Asthma in Costa Rica study. Asthma affection status was defined through a physician's diagnosis of asthma, and most participants with asthma also had airway hyperresponsiveness (AHR) to methacholine. Family-based association tests for single variants were performed to assess the associations with lung function phenotypes.ResultsA genome-wide significant association was identified between baseline FEV1/FVC ratio and a single-nucleotide polymorphism in the top hit cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) (rs12051168; P = 3.6 × 10-8 in the unadjusted model) that retained suggestive significance in the covariate-adjusted model (P = 5.6 × 10-6). Rs12051168 was also nominally associated with other related phenotypes: baseline FEV1 (P = 3.3 × 10-3), postbronchodilator (PB) FEV1 (7.3 × 10-3), and PB FEV1/FVC ratio (P = 2.7 × 10-3). The identified baseline FEV1/FVC ratio and rs12051168 association was meta-analyzed and replicated in three independent cohorts in which most participants with asthma also had confirmed AHR (combined weighted z-score P = .015) but not in cohorts without information about AHR.ConclusionsThese findings suggest that using specific asthma characteristics, such as AHR, can help identify more genetically homogeneous asthma subgroups with genotype-phenotype associations that may not be observed in all children with asthma. CRISPLD2 also may be important for baseline lung function in individuals with asthma who also may have AHR.

Published
2019

26. Inhaled corticosteroid response in youth with asthma and history of child maltreatment.

Author

Gaietto, Kristina, Han, Yueh Ying, Rosser, Franziska J., Forno, Erick, Canino, Glorisa, Marsland, Anna L., and Celedón, Juan C.

Subjects
METERED-dose inhalers, AFRICAN American children, CHILD abuse, REPORTING of child abuse, PHYSICAL abuse, ASTHMATICS
Abstract

The article explores the relationship between child maltreatment and inhaled corticosteroid (ICS) responsiveness in youth with asthma. The study, conducted on African American and Puerto Rican youth aged 8-20 years, found that children with a history of maltreatment were more likely to experience improved asthma-related quality of life after ICS treatment compared to those without such history. Despite limitations in statistical power and generalizability, the findings highlight the importance of ICS treatment for children with asthma and maltreatment history. The study suggests that ICS may be more beneficial for youth with maltreatment history due to prior suboptimal asthma management or enhanced perception of improvement in quality of life. [Extracted from the article]

Published
2024
Full Text
View/download PDF

27. A Pilot Randomized Control Trial Demonstrating the Efficacy of the SIESTA Sleep Hygiene Intervention.

Author

Koinis-Mitchell, Daphne, Boergers, Julie, Yeo, Anna J., Molera, Grace, Kopel, Sheryl J., McQuaid, Elizabeth L., Chen, Katie, Wolfson, Amy R., Chavez, Ligia, Jandasek, Barbara, and Canino, Glorisa

Subjects
RESEARCH funding, EVALUATION of human services programs, PILOT projects, STATISTICAL sampling, POVERTY areas, RANDOMIZED controlled trials, METROPOLITAN areas, RESEARCH methodology, SLEEP quality, SLEEP hygiene, SCHOOL health services
Abstract

Shorter sleep duration can negatively impact children's daytime functioning and health. Latino children living near urban areas in the Mainland U.S. and Island Puerto Rico (PR) can be exposed to urban poverty and sociocultural stressors that challenge optimal sleep outcomes. Interventions to improve urban Latino children's sleep health should consider families' cultural background and environmental context to enhance acceptability and feasibility. This work describes our stepwise, multimethod approach to adapting a culturally and contextually tailored "School Intervention to Enhance Latino Students' Time Asleep (SIESTA)" for sixth- to eighth-grade Latino children residing in Greater Providence and San Juan and findings from a pilot randomized control trial (RCT) demonstrating SIESTA's efficacy. Results indicated high acceptability and greater improvement of sleep duration and behaviors in SIESTA versus control participants. The SIESTA shows potential to improve sleep outcomes in urban Latino middle schoolers. Results will inform a large-scale RCT to evaluate SIESTA's effectiveness and barriers to implementation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Intra-session test-retest reliability of functional connectivity in infants

Author

Wang, Yun, Hinds, Walter, Duarte, Cristiane S, Lee, Seonjoo, Monk, Catherine, Wall, Melanie, Canino, Glorisa, Milani, Ana Carolina C., Jackowski, Andrea, Mamin, Marina Griorgi, Foerster, Bernd U., Gingrich, Jay, Weissman, Myrna M, Peterson, Bradley S., Semanek, David, Perez, Edna Acosta, Labat, Eduardo, Torres, Ioannisely Berrios, Da Silva, Ivaldo, Parente, Camila, Abdala, Nitamar, and Posner, Jonathan

Published
2021
Full Text
View/download PDF

34. A meta-analysis of genome-wide association studies of asthma in Puerto Ricans

Author

Yan, Qi, Brehm, John, Pino-Yanes, Maria, Forno, Erick, Lin, Jerome, Oh, Sam S, Acosta-Perez, Edna, Laurie, Cathy C, Cloutier, Michelle M, Raby, Benjamin A, Stilp, Adrienne M, Sofer, Tamar, Hu, Donglei, Huntsman, Scott, Eng, Celeste S, Conomos, Matthew P, Rastogi, Deepa, Rice, Kenneth, Canino, Glorisa, Chen, Wei, Barr, R Graham, Burchard, Esteban G, and Celedón, Juan C

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lung, Human Genome, Clinical Research, Genetics, Asthma, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Adolescent, Adult, Child, Chromosomes, Human, Pair 17, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Hispanic or Latino, Humans, Linkage Disequilibrium, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Puerto Rico, Young Adult, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology
Abstract

Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans.We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford-Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10-12) at IKZF3 Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as IKZF3 (e.g. ZPBP2, ORMDL3 and GSDMB) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 at GSDMB, but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs at IL1RL1, TSLP and GSDMB but not for IL33Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.

Published
2017

35. Dibattiti. Ripensare le priorità nei finanziamenti della ricerca sulla salute mentale

Author

Lewis-Fernández, Roberto, Rotheram-Borus, Mary Jane, Trotter Betts, Virginia, Greenman, Lisa, M. Essock, Susan, I. Escobar, Javier, Barch, Deanna, F. Hogan, Michael, Areàn, Patricia A, Druss, Benjamin G, DiClemente, Ralph J, McGlashan, Thomas H, Jeste, Dilip V, Proctor, Enola K, Ruiz, Pedro, Rush, A John, Canino, Glorisa J, Bell, Carl C, Henry, Renata, and Iversen, Portia

Published
2017

37. Parental psychopathology and posttraumatic stress in Puerto Ricans: the role of childhood adversity and parenting practices.

Author

Zhen‐Duan, Jenny, Alvarez, Kiara, Zhang, Lulu, Cruz‐Gonzalez, Mario, Kuo, Josephine, Falgas‐Bagué, Irene, Bird, Hector, Canino, Glorisa, Duarte, Cristiane S., and Alegría, Margarita

Subjects
POST-traumatic stress disorder, RESEARCH funding, PARENT-child relationships, PARENTING, DESCRIPTIVE statistics, PSYCHOLOGY of parents, PUERTO Ricans, CONFIDENCE intervals, PATHOLOGICAL psychology, ADVERSE childhood experiences, TRANSITION to adulthood, CHILDREN
Abstract

Background: Parental psychopathology is associated with their children's posttraumatic stress symptoms (PTSS). However, the mechanisms through which this occurs remain unclear. We hypothesized that exposure to childhood adversities is the mechanism linking parental psychopathology to child PTSS and that parenting practices moderated these associations. Methods: Participants (N = 1,402) with an average age of 24.03 years old (SD = 2.20), were all Puerto Ricans (50% Male and 50% Female) from the Boricua Youth Study, which is a four‐wave longitudinal study spanning almost 20 years, following individuals from childhood (ages 5–13 at Wave 1) to young adulthood. Measured variables include parental psychopathology at Wave 1, childhood adversities and parenting practices at Waves 2–3, and PTSS at Wave 4. A traditional mediation model estimated the association between parental psychopathology and child PTSS via childhood adversities. A moderated mediation model was used to examine whether parenting practices moderated this mediation model. Results: Results showed that the total effect of parental psychopathology at Wave 1 on PTSS at Wave 4 was fully mediated by childhood adversities at Waves 2–3 (direct effect b = 1.72, 95% CI = [−0.09, 3.83]; indirect effect b = 0.40, 95% CI = [0.15, 0.81]). In addition, the magnitude of this pathway varied by levels of parenting practices (i.e. parental monitoring and parent–child relationship quality). Specifically, the indirect effect of additional adversities in the psychopathology‐PTSS link was stronger with higher levels of parental monitoring but weaker with higher parent–child relationship quality scores. Conclusions: Intergenerational continuity of psychopathology may be mitigated through the prevention of additional childhood adversities via upstream interventions, emphasizing providing parents with mental health needs with parenting tools. Family‐based interventions focused on providing families with the tools to improve parent–child relationships may reduce the negative impact of childhood adversities on mental health across the life course. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. Nasal DNA methylation profiling of asthma and rhinitis

Author

Qi, Cancan, Jiang, Yale, Yang, Ivana V., Forno, Erick, Wang, Ting, Vonk, Judith M., Gehring, Ulrike, Smit, Henriëtte A., Milanzi, Edith B., Carpaij, Orestes A., Berg, Marijn, Hesse, Laura, Brouwer, Sharon, Cardwell, Jonathan, Vermeulen, Cornelis J., Acosta-Pérez, Edna, Canino, Glorisa, Boutaoui, Nadia, van den Berge, Maarten, Teichmann, Sarah A., Nawijn, Martijn C., Chen, Wei, Celedón, Juan C., Xu, Cheng-Jian, and Koppelman, Gerard H.

Published
2020
Full Text
View/download PDF

40. Rethinking funding priorities in mental health research.

Author

Lewis-Fernández, Roberto, Rotheram-Borus, Mary Jane, Betts, Virginia Trotter, Greenman, Lisa, Essock, Susan M, Escobar, Javier I, Barch, Deanna, Hogan, Michael F, Areán, Patricia A, Druss, Benjamin G, DiClemente, Ralph J, McGlashan, Thomas H, Jeste, Dilip V, Proctor, Enola K, Ruiz, Pedro, Rush, A John, Canino, Glorisa J, Bell, Carl C, Henry, Renata, and Iversen, Portia

Subjects
Humans, Mental Health, Biomedical Research, Behavioral and Social Science, Prevention, Brain Disorders, Mental health, Good Health and Well Being, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Mental health research funding priorities in high-income countries must balance longer-term investment in identifying neurobiological mechanisms of disease with shorter-term funding of novel prevention and treatment strategies to alleviate the current burden of mental illness. Prioritising one area of science over others risks reduced returns on the entire scientific portfolio.

Published
2016

41. Association of Types of Life Events with Depressive Symptoms among Puerto Rican Youth

Author

Jaschek, Graciela, Carter-Pokras, Olivia D, He, Xin, Lee, Sunmin, and Canino, Glorisa

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Brain Disorders, Prevention, Mental Health, Pediatric, Depression, Mental health, Good Health and Well Being, Adolescent, Child, Female, Hispanic or Latino, Humans, Life Change Events, Longitudinal Studies, Male, New York City, Parent-Child Relations, Puerto Rico, Social Environment, Social Support, General Science & Technology
Abstract

The main objective of this study was to examine the association between four types of adverse life events (family environment, separation, social adversity, and death) and the development of depressive symptoms among Puerto Rican youth. This was a secondary analysis using three waves (2000-2004) of interview data from the Boricua Youth Study of 10-13 year old Puerto Rican youth residing in New York and Puerto Rico with no depressive symptoms at baseline (n = 977). Depressive symptoms increased with an increase in social adversity, separation, death, and death events. Youth support from parents was a significant protective factor for all adverse events and parent coping was a protective factor in social adversity events. Relying on standard diagnostic tools is ideal to identify youth meeting the criteria for a diagnosis of depression but not useful to detect youth who present with subclinical levels of depression. Youth with sub-clinical levels of depression will not get treated and are at increased risk of developing depression later in life. Adverse life events are potentially relevant to use in conjunction with other screening tools to identify Puerto Rican youth who have subclinical depression and are at risk of developing depression in later adolescence.

Published
2016

43. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Author

Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Palmer Allred, Nicholette (Nichole), Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K., Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Beaty, Terri, Becker, Diane, Becker, Lewis, Beer, Rebecca, Begum, Ferdouse, Beitelshees, Amber, Benjamin, Emelia, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Boerwinkle, Eric, Borecki, Ingrid, Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Bunting, Karen, Burchard, Esteban, Cardwell, Jonathan, Carty, Cara, Casaburi, Richard, Casella, James, Chaffin, Mark, Chang, Christy, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Chen, Yii-Der Ida, Cho, Michael H., Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, Das, Sayantan, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Do, Ron, Duan, Qing, Duggirala, Ravi, Durda, Peter, Dutcher, Susan, Eaton, Charles, Ekunwe, Lynette, Ellinor, Patrick, Emery, Leslie, Farber, Charles, Farnam, Leanna, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Yan, Gass, Margery, Gelb, Bruce, Geng, Xiaoqi (Priscilla), Germer, Soren, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Haessler, Jeff, Hall, Michael, Harris, Daniel, Hawley, Nicola, He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hokanson, John, Holly, Kramer, Hong, Elliott, Hoth, Karin, (Agnes) Hsiung, Chao, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Jhun, Min A., Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kachroo, Priyadarshini, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kathiresan, Sekar, Kaufman, Laura, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Krauter, Stephanie, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Seunggeun Shawn, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Yun, Lin, Honghuang, Lin, Keng Han, Liu, Simin, Liu, Yongmei, Loos, Ruth, Lubitz, Steven, Lunetta, Kathryn, Luo, James, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manson, JoAnn, Margolin, Lauren, Martin, Lisa, Mathai, Susan, Mathias, Rasika, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, Mei, Hao, Meyers, Deborah A., Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L., Mitchell, Braxton, Montasser, May E., Musani, Solomon, Mwasongwe, Stanford, Mychaleckyj, Josyf C., Nadkarni, Girish, Naik, Rakhi, Natarajan, Pradeep, Nekhai, Sergei, Nickerson, Deborah, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Pankow, James, Papanicolaou, George, Parker, Margaret, Parsa, Afshin, Penchev, Sara, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S., Phillips, Sam, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Prokopenko, Dmitry, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Ramachandran, Vasan, Rao, D.C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Regan, Elizabeth, Reiner, Alex, Rice, Ken, Rich, Stephen, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sakornsakolpat, Phuwanat, Salimi, Shabnam, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay, Scheller, Christopher, Schmidt, Ellen, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sheehan, Vivien, Shetty, Amol, Shetty, Aniket, Sheu, Wayne Hui-Heng, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne, Streeten, Elizabeth, Sung, Yun Ju, Su-Lasky, Jessica, Sylvia, Jody, Szpiro, Adam, Sztalryd, Carole, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Tinker, Lesley, Tirschwell, David, Tiwari, Hemant, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wan, Emily, Wang, Fei Fei, Watson, Karol, Weeks, Daniel E., Weir, Bruce, Weiss, Scott, Weng, Lu-Chen, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Wong, Quenna, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yang, Rongze, Zaghloul, Norann, Zekavat, Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zheng, Xiuwen, Zhi, Degui, Zhou, Xiang, Zody, Michael, Zoellner, Sebastian, Hecker, Julian, Chawes, Bo L., Ahluwalia, Tarunveer S., Kelly, Rachel S., Chu, Su H., Virkud, Yamini V., Huang, Mengna, Barnes, Kathleen C., Burchard, Esteban G., Eng, Celeste, Hu, Donglei, Celedón, Juan C., Levin, Albert M., Gui, Hongsheng, Forno, Erick, Mak, Angel C.Y., Avila, Lydiana, Soto-Quiros, Manuel E., Cloutier, Michelle M., Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A., Weiss, Scott T., and Lasky-Su, Jessica A.

Published
2019
Full Text
View/download PDF

45. Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Author

King, Charlotte, McKenna, Amanda, Farzan, Niloufar, Vijverberg, Susanne J., van der Schee, Marc P., Maitland-van der Zee, Anke H., Arianto, Lambang, Bisgaard, Hans, BØnnelykke, Klaus, Berce, Vojko, PotoČnik, Uros, Repnik, Katja, Carleton, Bruce, Daley, Denise, Chew, Fook Tim, Chiang, Wen Chin, Sio, Yang Yie, Cloutier, Michelle M., Den Dekker, Herman T., Duijts, Liesbeth, de Jongste, Johan C., Dijk, F. Nicole, Flores, Carlos, Hernandez-Pacheco, Natalia, Mukhopadhyay, Somnath, Basu, Kaninika, Tantisira, Kelan G., Verhamme, Katia M., Celedón, Juan C., Forno, Erick, Canino, Glorisa, Francis, Ben, Pirmohamed, Munir, Sinha, Ian, and Hawcutt, Daniel B.

Published
2020
Full Text
View/download PDF

47. Family Influences on the Relationship Between Hurricane Exposure and Ataques de Nervios

Author

Felix, Erika D, You, Sukkyung, and Canino, Glorisa

Subjects
Behavioral and Social Science, Basic Behavioral and Social Science, Pediatric, Prevention, Mental Health, Clinical Research, Pediatric Research Initiative, Aetiology, 2.3 Psychological, social and economic factors, Mental health, Disaster, Culture, Ataques de nervios, Children, Public Health and Health Services, Psychology, Linguistics, Family Studies
Abstract

This study focused on characteristics of the family environment that may influence the relationship between hurricane exposure and ataques de nervios in Puerto Rican children and youth. Approximately 18 months after Hurricane Georges hit Puerto Rico in 1998, participants were randomly selected based on a probability household sample using 1990 US Census block groups. Caregivers and children were interviewed about past year and lifetime experience of ataques de nervios, hurricane exposure, and the family environment in Spanish. Areas of the family environment assessed include parent-child relationship quality, parent-child involvement, parental monitoring, discipline, and parents' relationship quality. Structural equation models were estimated for parents and children, and by age group. For children (4-10 years old, N = 582), hurricane exposure was directly related to lifetime experience of ataques, but not for past year experience of ataques. However, for children, none of the family variables had a significant mediating role in the relation between hurricane exposure and either past year or lifetime experience of ataques; rather, parent-child involvement decreased risk for lifetime and past year ataques. For youth (11-17 years old, N = 569), per youth report, positive discipline mediated the hurricane exposure to lifetime experience of ataques relationship, whereas parents' relationship quality mediated the relationship between exposure and past year experience of ataques. Hurricane exposure decreased positive discipline and parents' relationship quality, and positive discipline and parents' relationship quality decreased risk for ataques. Per parent report, parent-child involvement decreased risk for past year or lifetime experience of ataques. Implications for post-disaster mental health recovery efforts are discussed.

Published
2015

48. Stress and Bronchodilator Response in Children with Asthma

Author

Brehm, John M, Ramratnam, Sima K, Tse, Sze Man, Croteau-Chonka, Damien C, Pino-Yanes, Maria, Rosas-Salazar, Christian, Litonjua, Augusto A, Raby, Benjamin A, Boutaoui, Nadia, Han, Yueh-Ying, Chen, Wei, Forno, Erick, Marsland, Anna L, Nugent, Nicole R, Eng, Celeste, Colón-Semidey, Angel, Alvarez, María, Acosta-Pérez, Edna, Spear, Melissa L, Martinez, Fernando D, Avila, Lydiana, Weiss, Scott T, Soto-Quiros, Manuel, Ober, Carole, Nicolae, Dan L, Barnes, Kathleen C, Lemanske, Robert F, Strunk, Robert C, Liu, Andrew, London, Stephanie J, Gilliland, Frank, Sleiman, Patrick, March, Michael, Hakonarson, Hakon, Duan, Qing Ling, Kolls, Jay K, Fritz, Gregory K, Hu, Donglei, Fani, Negar, Stevens, Jennifer S, Almli, Lynn M, Burchard, Esteban G, Shin, Jaemin, McQuaid, Elizabeth L, Ressler, Kerry, Canino, Glorisa, and Celedón, Juan C

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Pediatric, Asthma, Behavioral and Social Science, Clinical Research, Mental Health, Lung, Genetics, Aetiology, 2.3 Psychological, social and economic factors, Respiratory, Good Health and Well Being, Adolescent, Anxiety, Bronchodilator Agents, Case-Control Studies, Child, Cross-Sectional Studies, Down-Regulation, Female, Genetic Markers, Genotype, Humans, Linear Models, Male, Multivariate Analysis, Polymorphism, Single Nucleotide, Puerto Rico, Receptors, Adrenergic, beta-2, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I, Rhode Island, Risk Factors, Stress, Psychological, Treatment Outcome, asthma, Puerto Ricans, bronchodilator response, stress, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleStress is associated with asthma morbidity in Puerto Ricans (PRs), who have reduced bronchodilator response (BDR).ObjectivesTo examine whether stress and/or a gene regulating anxiety (ADCYAP1R1) is associated with BDR in PR and non-PR children with asthma.MethodsThis was a cross-sectional study of stress and BDR (percent change in FEV1 after BD) in 234 PRs ages 9-14 years with asthma. We assessed child stress using the Checklist of Children's Distress Symptoms, and maternal stress using the Perceived Stress Scale. Replication analyses were conducted in two cohorts. Polymorphisms in ADCYAP1R1 were genotyped in our study and six replication studies. Multivariable models of stress and BDR were adjusted for age, sex, income, environmental tobacco smoke, and use of inhaled corticosteroids.Measurements and main resultsHigh child stress was associated with reduced BDR in three cohorts. PR children who were highly stressed (upper quartile, Checklist of Children's Distress Symptoms) and whose mothers had high stress (upper quartile, Perceived Stress Scale) had a BDR that was 10.2% (95% confidence interval, 6.1-14.2%) lower than children who had neither high stress nor a highly stressed mother. A polymorphism in ADCYAP1R1 (rs34548976) was associated with reduced BDR. This single-nucleotide polymorphism is associated with reduced expression of the gene for the β2-adrenergic receptor (ADRB2) in CD4(+) lymphocytes of subjects with asthma, and it affects brain connectivity of the amygdala and the insula (a biomarker of anxiety).ConclusionsHigh child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced BDR in children with asthma. This is likely caused by down-regulation of ADRB2 in highly stressed children.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results