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525 results on '"Canevari S"'

1. A class of minimal hypersurfaces in $\mathbb{Q}^N(c)$

Author

Filho, C. do Rei and Canevari, S.

Subjects
Mathematics - Differential Geometry, 53B25
Abstract

We prove that a minimal hypersurfaces $f\colon M^{3} \to \mathbb{Q}^4(c)$ with nonzero three distinct principal curvature cannot be isometrically immersed in $\mathbb{Q}^4(\tilde{c}), \ \tilde{c}\neq c$. In the other cases, we present a description of such hypersurfaces., Comment: 17 pages

Published
2023

2. Hypersurfaces of two space forms and conformally flat hypersurfaces

Author

Canevari, S. and Tojeiro, R.

Subjects
Mathematics - Differential Geometry, 53B25
Abstract

We address the problem of determining the hypersurfaces $f\colon M^{n} \to \mathbb{Q}_s^{n+1}(c)$ with dimension $n\geq 3$ of a pseudo-Riemannian space form of dimension $n+1$, constant curvature $c$ and index $s\in \{0, 1\}$ for which there exists another isometric immersion $\tilde{f}\colon M^{n} \to \mathbb{Q}^{n+1}_{\tilde s}(\tilde{c})$ with $\tilde{c}\neq c$. For $n\geq 4$, we provide a complete solution by extending results for $s=0=\tilde s$ by do Carmo and Dajczer and by Dajczer and the second author. Our main results are for the most interesting case $n=3$, and these are new even in the Riemannian case $s=0=\tilde s$. In particular, we characterize the solutions that have dimension $n=3$ and three distinct principal curvatures. We show that these are closely related to conformally flat hypersurfaces of $\mathbb{Q}_s^{4}(c)$ with three distinct principal curvatures, and we obtain a similar characterization of the latter that improves a theorem by Hertrich-Jeromin. We also derive a Ribaucour transformation for both classes of hypersurfaces, which gives a process to produce a family of new elements of those classes, starting from a given one, in terms of solutions of a linear system of PDE's. This enables us to construct explicit examples of three-dimensional solutions of the problem, as well as new explicit examples of three-dimensional conformally flat hypersurfaces that have three distinct principal curvatures., Comment: 46 pages

Published
2015

11. An immunologically relevant rodent model demonstrates safety of therapy using a tumour‐specific IgE

Author

Josephs, D. H., Nakamura, M., Bax, H. J., Dodev, T. S., Muirhead, G., Saul, L., Karagiannis, P., Ilieva, K. M., Crescioli, S., Gazinska, P., Woodman, N., Lombardelli, C., Kareemaghay, S., Selkirk, C., Lentfer, H., Barton, C., Canevari, S., Figini, M., Downes, N., Dombrowicz, D., Corrigan, C. J., Nestle, F. O., Jones, P. S., Gould, H. J., Blower, P. J., Tsoka, S., Spicer, J. F., and Karagiannis, S. N.

Subjects
AllergoOncology, Receptors, IgE, Tumor Necrosis Factor-alpha, Immunoglobulin E, Statistics, Nonparametric, Rats, Antibodies, Monoclonal, Murine-Derived, Mice, Treatment Outcome, Experimental Allergy and Immunology, Cell Line, Tumor, Immunoglobulin G, Neoplasms, Models, Animal, cancer, Animals, Humans, Original Article, rat, Folate Receptor 1, IgE, Immunotherapy, ORIGINAL ARTICLES, Protein Binding
Abstract

Background Designing biologically informative models for assessing the safety of novel agents, especially for cancer immunotherapy, carries substantial challenges. The choice of an in vivo system for studies on IgE antibodies represents a major impediment to their clinical translation, especially with respect to class‐specific immunological functions and safety. Fcε receptor expression and structure are different in humans and mice, so that the murine system is not informative when studying human IgE biology. By contrast, FcεRI expression and cellular distribution in rats mirror that of humans. Methods We are developing MOv18 IgE, a human chimeric antibody recognizing the tumour‐associated antigen folate receptor alpha. We created an immunologically congruent surrogate rat model likely to recapitulate human IgE‐FcεR interactions and engineered a surrogate rat IgE equivalent to MOv18. Employing this model, we examined in vivo safety and efficacy of antitumour IgE antibodies. Results In immunocompetent rats, rodent IgE restricted growth of syngeneic tumours in the absence of clinical, histopathological or metabolic signs associated with obvious toxicity. No physiological or immunological evidence of a “cytokine storm” or allergic response was seen, even at 50 mg/kg weekly doses. IgE treatment was associated with elevated serum concentrations of TNFα, a mediator previously linked with IgE‐mediated antitumour and antiparasitic functions, alongside evidence of substantially elevated tumoural immune cell infiltration and immunological pathway activation in tumour‐bearing lungs. Conclusion Our findings indicate safety of MOv18 IgE, in conjunction with efficacy and immune activation, supporting the translation of this therapeutic approach to the clinical arena.

Published
2018

12. Development of a Multiomics Database for Personalized Prognostic Forecasting in Head and Neck Cancer: The Big Data to Decide EU Project

Author

Cavalieri, Stefano, Cecco, L. de, Brakenhoff, R.H., Serafini, M.S., Canevari, S., Rossi, S., Lanfranco, D., Hoebers, F.J.P., Wesseling, F.W.R., Keek, S., Scheckenbach, K., Mattavelli, D., Hoffmann, T., López Pérez, L., Fico, G., Bologna, M., Nauta, I., Leemans, C.R., Trama, A., Klausch, T., Berkhof, J.H., Tountopoulos, V., Shefi, R., Mainardi, L., Mercalli, F., Poli, T., Licitra, L., Wesarg, S., and Publica

Subjects
Lead Topic: Individual Health, Research Line: Modeling (MOD), Research Line: Machine Learning (ML), Big Data, patient model, oral cancer
Abstract

Background Despite advances in treatments, 30% to 50% of stage III-IV head and neck squamous cell carcinoma (HNSCC) patients relapse within 2 years after treatment. The Big Data to Decide (BD2Decide) project aimed to build a database for prognostic prediction modeling. Methods Stage III-IV HNSCC patients with locoregionally advanced HNSCC treated with curative intent (1537) were included. Whole transcriptomics and radiomics analyses were performed using pretreatment tumor samples and computed tomography/magnetic resonance imaging scans, respectively. Results The entire cohort was composed of 71% male (1097)and 29% female (440): oral cavity (429, 28%), oropharynx (624, 41%), larynx (314, 20%), and hypopharynx (170, 11%); median follow-up 50.5 months. Transcriptomics and imaging data were available for 1284 (83%) and 1239 (80%) cases, respectively; 1047 (68%) patients shared both. Conclusions This annotated database represents the HNSCC largest available repository and will enable to develop/validate a decision support system integrating multiscale data to explore through classical and machine learning models their prognostic role.

Published
2021

17. Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcεRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity

Author

Rudman, S. M., Josephs, D. H., Cambrook, H., Karagiannis, P., Gilbert, A. E., Dodev, T., Hunt, J., Koers, A., Montes, A., Taams, L., Canevari, S., Figini, M., Blower, P. J., Beavil, A. J., Nicodemus, C. F., Corrigan, C., Kaye, S. B., Nestle, F. O., Gould, H. J., Spicer, J. F., and Karagiannis, S. N.

Published
2011
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19. P2828Survival after an out-of-hospital cardiac arrest decrease over time in all Utstein categories. The importance of a long follow-up

Author

Baldi, E, primary, Buratti, S, additional, Contri, E, additional, Canevari, S, additional, Molinari, S, additional, Pagani, M, additional, Lusona, B, additional, Mojoli, F, additional, Bertona, R, additional, Osti, R, additional, Palo, A, additional, Oltrona Visconti, L, additional, De Ferrari, G M, additional, and Savastano, S, additional

Published
2019
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24. PO-161 Mutational profile of epithelial, non-glandular sinonasal cancers into 2 prospective clinical trials

Author

De Cecco, L., primary, Serafini, M.S., additional, Canevari, S., additional, Penso, D., additional, Nicolai, P., additional, Castelnuovo, P., additional, Benazzo, M., additional, Sponghini, A., additional, Orlandi, E., additional, Vischioni, B., additional, Piazza, C., additional, Resteghini, C., additional, Licitra, L., additional, and Bossi, P., additional

Published
2019
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26. Genomics features (GF) and integration with MRI radiomics features (RF) to develop a prognostic model in oral cavity squamous cell carcinoma (OSCC)

Author

Cavalieri, S., primary, De Cecco, L., additional, Calareso, G., additional, Silva, M., additional, Gazzani, S.E., additional, Bologna, M., additional, Nauta, I., additional, Wesseling, F., additional, Lopez Perez, L., additional, Shefi, R., additional, Tountopoulos, V., additional, Fico, G., additional, Scheckenbach, K., additional, Brakenhoff, R.H., additional, Hoebers, F., additional, Canevari, S., additional, Poli, T., additional, Licitra, L., additional, and Mainardi, L., additional

Published
2018
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28. Gene-expression profiles of primary and metastatic lesions in head and neck squamous cell carcinoma

Author

Alfieri, S., primary, Bossi, P., additional, Galbiati, D., additional, Giannoccaro, M., additional, Pilotti, S., additional, Perrone, F., additional, Paielli, N., additional, Tonella, L., additional, Bergamini, C., additional, Granata, R., additional, Resteghini, C., additional, Cavalieri, S., additional, Iacovelli, N.A., additional, Orlandi, E., additional, Locati, L.D., additional, Licitra, L., additional, Canevari, S., additional, and De Cecco, L., additional

Published
2017
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30. Monoclonal Antibodies Against Breast Cancer

Author

Colnaghi, M. I., Mènard, S., Mariani-Costantini, R., Canevari, S., Miotti, S., Della Torre, G., Orefice, S., Andreola, S., Aaronson, Stuart A., editor, Frati, Luigi, editor, and Verna, Roberto, editor

Published
1984
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32. Dissecting heterogeneity and molecular mechanisms involved in paranasal sinus cancer

Author

De Cecco, L., primary, Granata, R., additional, Orlandi, E., additional, Fallai, C., additional, Licitra, L., additional, Giannoccaro, M., additional, Perrone, F., additional, Pilotti, S., additional, Quattrone, P., additional, Facco, C., additional, Sessa, F., additional, Turri-Zanoni, M., additional, Battaglia, P., additional, Castelnuovo, P., additional, Antognoni, P., additional, Paielli, N., additional, Tonella, L., additional, Canevari, S., additional, and Bossi, P., additional

Published
2016
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38. Late abstracts 186–187

Author

Jaehne, J., Meyer, H. -J., Wittekind, Ch., Maschek, H., Pichlmayr, R., Jacobi, G., Weiermann, G., Vitzthum, H. Gräfin, Schwabe, D., Manegold, Ch., Krempien, B., Kaufmann, M., Bailly, M., Doré, J. -F., Fodstad, Ø., Kjønniksen, I., Brøgger, A., Flørenes, V. A., Pihl, A., Aamdal, S., Nesland, J. M., Geldof, A. A., Rao, B. R., De Giovanni, C., Lollini, P. -L., Del Re, B., Scotlandi, K., Nicoletti, G., Nanni, P., Van Muijen, G. N. P., Van Der Wiel-Miezenbeek, J. M., Cornelissen, L. M. H. A., Jansen, C. F. J., Ruiter, D. J., Kieler, J., Oda, Y., Tokuriki, Y., Tenang, E. M., Lamb, J. F., Galante, E., Zanoni, F., Galluzzi, D., Cerrotta, A., Martelli, G., Guzzon, A., Reduzzi, D., Barberá-Guillem, E., Barceló, J. R., Urcelay, B., Alonso-Varona, A. I., Vidal-Vanaclocha, F., Bassukas, I. D., Maurer-Schultze, B., Storeng, R., Manzotti, C., Pratesi, G., Schachert, G., Fidler, I. J., Grimstad, I. A., Rutt, G. Th., Riesinger, P., Frank, J., Neumann, G., Wissler, J. H., Bastert, G., Liebrich, W., Lehner, B., Gonzer, S., Schlag, P., Vehmeyer, K., Hajto, T., Gabius, H. -J., Funke, I., Schlimok, G., Bock, B., Dreps, A., Schweiberer, B., Riethmüller, G., Nicolai, U., Vykoupil, K. -F., Wolf, M., Havemann, K., Georgii, A., Bertrand, S., N'Guyen, M. -J., Siracky, J., Kysela, B., Siracka, E., Pflüger, E., Schirrmacher, V., Boyano, M. D., Hanania, N., Poupon, M. F., Sherbet, G. V., Lakshmi, M. S., Van Roy, F., Vleminckx, K., Fiers, W., Dragonetti, C., De Bruyne, G., Messiaen, L., Mareel, M., Kuhn, S., Choritz, H., Schmid, U., Bihl, H., Griesbach, A., Matzku, S., Eccles, S. A., Purvies, H. P., Miller, F. R., McEachern, D., Ponton, A., Waghorne, C., Coulombe, B., Kerbel, R. S., Breitman, M., Skup, D., Gingras, M. C., Jarolim, L., Wright, J. A., Greenberg, A. H., N'Guyen, M. J., Allavena, G., Melchiori, A., Aresu, O., Percario, M., Parodi, S., Schmidt, J., Kars, P., Chader, G., Albini, A., Zöller, M., Lissitzky, J. C., Bouzon, M., Martin, P. M., Grossi, I. M., Taylor, J. D., Honn, K. V., Koch, B., Baum, W., Giedl, J., Gabius, H. J., Kalden, J. R., Hakim, A. A., LadÁnyi, A., Timár, J., Moczar, E., Lapis, K., Müller, K., Wolf, M. F., Benz, B., Schumacher, K., Kemmner, W., Morgenthaler, J., Brossmer, R., Hagmar, B., Burns, G., Erkell§, L. J., Ryd, W., Paku, S., Rot, A., Hilario, E., Unda, F., Simón, J., Aliño, S. F., Sargent, N. S. E., Burger, M. M., Altevogt, P., Kowitz, A., Chopra, H., Bandlow, G., Nagel, G. A., Lotan, R., Carralero, D., Lotan, D., Raz, A., Skubitz, A. P. N., Koliakos, G. G., Furcht, L. T., Charonis, A. S., Hamann, A., Jablonski-Westrich, D., Jonas, P., Harder, R., Butcher, E. C., Thiele, H. G., Breillout, F., Antoine, E., Lascaux, V., Boxberger, H. -J., Paweletz, N., Bracke, M., Vyncke, B., Opdenakker, G., Castronovo, V., Foidart, J. -M., Camacho, M., Fras, A. Fabra, Llorens, A., Rutllant, M. L., Erkell, L. J., Brunner, G., Heredia, A., Imhoff, J. M., Burtin, P., Nakajima, M., Lunec, J., Parker, C., Fennelly, J. A., Smith, K., Roossien, F. F., La Rivière, G., Roos, E., Erdel, M., Trefz, G., Spiess, E., Ebert, W., Verhaegen, S., Remels, L., Verschueren, H., Dekegel, D., De Baetselier, P., Van Hecke, D., Hannecart-Pokorni, E., Falkvoll, K. H., Alonso, A., Baroja, A., Sebbag, U., Barbera-Guillem, E., Behrens, J., Mareel, M. M., Birchmeier, W., Waterhouse, P., Khokha, R., Chambers, A., Yagel, S., Lala, P. K., Denhardt, D. T., Hennes, R., Frantzen, F., Keller, R., Schwartz-Albiez, R., Fondaneche, M. C., Mignatti, P., Tsuboi, R., Robbins, E., Rifkin, D. B., Overall, C. M., Sacchi, A., Falcioni, R., Piaggio, G., Rizzo, M. G., Perrotti, N., Kennel, S. J., Girschick, H., Müller-Hermelink, H. K., Vollmers, H. P., Wenzel, A., Liu, S., Günthert, U., Wesch, V., Giles, M., Ponta, H., Herrlich, P., Stade, B., Hupke, U., Holzmann, B., Johnson, J. P., Sauer, A., Roller, E., Klumpp, B., Güttler, N., Lison, A., Walk, A., Redini, F., Moczar, M., Leoni, F., Da Dalt, M. G., Ménard, S., Canevari, S., Miotti, S., Tagliabue, E., Colnaghi, M. I., Ostmeier, H., Suter, L., Possati, L., Rosciani, C., Recanatini, E., Beatrici, V., Diambrini, M., Polito, M., Rothbächer, U., Eisenbach, L., Plaksin, D., Gelber, C., Kushtai, G., Gubbay, J., Feldman, M., Benke, R., Benedetto, A., Elia, G., Sala, A., Belardelli, F., Lehmann, J. M., Ladanyi, A., Hanisch, F. -G., Sölter, J., Jansen, V., Böhmer, G., Peter-Katalinic, J., Uhlenbruck, G., O'Connor, R., Müller, J., Kirchner, T., Bover, B., Tucker, G., Valles, A. M., Gavrilovic, J., Thiery, J. P., Kaufmann, A. M., Volm, M., Edel, G., Zühlsdorf, M., Voss, H., Wörmann, B., Hiddemann, W., De Neve, W., Van Den Berge, D., Van Loon, R., Storme, G., Zacharski, L. R., Wojtukiewicz, M. Z., Memoli, V., Kisiel, W., Kudryk, B. J., Stump, D., Piñol, G., Gonzalez-Garrigues, M., Fabra, A., Marti, F., Rueda, F., Lichtner, R. B., Khazaie, K., Timar, J., Greenzhevskaya, S. N., Shmalko, Yu. P., Hill, S. E., Rees, R. C., MacNeil, S., Millon, R., Muller, D., Eber, M., Abecassis, J., Betzler, M., Bahtsky, K. P., Umansky, V. Yu., Krivorotov, A. A., Balitskaya, E. K., Pridatko, O. E., Smelkova, M. I., Smirnov, I. M., Korczak, B., Fisher, C., Thody, A. J., Young, S. D., Hill, R. P., Frixen, U., Gopas, J., Segal, S., Hammerling, G., Bar-Eli, M., Rager-Zisman, B., Har-Vardi, I., Alon, Y., Hämmerling, G. J., Perez, M., Algarra, I., Collado, Ma. D., Peran, E., Caballero, A., Garrido, F., Turner, G. A., Blackmore, M., Stern, P. L., Thompson, S., Levin, I., Kuperman, O., Eyal, A., Kaneti, J., Notter, M., Knuth, A., Martin, M., Chauffert, B., Caignard, A., Hammann, A., Martin, F., Dearden, M. T., Pelletier, H., Dransfield, I., Jacob, G., Rogers, K., Pérez-Yarza, G., Cañavate, M. L., Lucas, R., Bouwens, L., Mantovani, G., Serri, F. G., Macciò, A., Zucca, M. V., Del Giacco, G. S., Pérez, M., Kärre, K., Apt, D., Traversari, C., Sensi, M., Carbone, G., Parmiani, G., Hainaut, P., Weynants, P., Degiovanni, G., Boon, T., Marquardt, P., Stulle, K., Wölfel, T., Herin, M., Van den Eynde, B., Klehmann, E., Büschenfelde, K. -H. Meyer zum, Samija, M., Gerenčer, M., Eljuga, D., Bašić, I., Heacock, C. S., Blake, A. M., D'Aleo, C. J., Alvarez, V. L., Gresser, I., Maury, C., Moss, J., Woodrow, D., von Ardenne, M., Krüger, W., Möller, P., Schachert, H. K., Itaya, T., Frost, P., Rodolfo, M., Salvi, C., Bassi, C., Huland, E., Huland, H., Sersa, G., Willingham, V., Hunter, N., Milas, L., Schild, H., von Hoegen, P., Mentges, B., Bätz, W., Suzuki, N., Mizukoshi, T., Sava, G., Ceschia, V., Zabucchi, G., Farkas-Himsley, H., Schaal, O., Klenner, T., Keppler, B., Alvarez-Diaz, A., Bizzari, J. P., Barbera-Guillem, F., Osterloh, B., Bartkowski, R., LÖhrke, H., Schwahn, E., Schafmayer, A., Goerttler, K., Cillo, C., Ling, V., Giavazzi, R., Vecchi, A., Luini, W., Garofalo, A., Iwakawa, M., Arundel, C., Tofilon, P., Giraldi, T., Perissin, L., Zorzet, S., Piccini, P., Pacor, S., Rapozzi, V., Fink, U., Zeuner, H., Dancygier, H., Classen, M., Lersch, C., Reuter, M., Hammer, C., Brendel, W., Mathé, G., Bourut, C., Chenu, E., Kidani, Y., Mauvernay, Y., Schally, A. V., Reizenstein, P., Gastiaburu, J., Comaru-Schally, A. M., Cupissol, D., Jasmin, C., Missot, J. L., Wingen, F., Schmähl, D., Pauwels-Vergely, C., Poupon, M. -F., Gasic, T. B., Ewaskiewicz, J. I., Gasic, G. J., Pápay, J., Mauvernay, R., Schally, A., Keiling, R., Hagipantelli, R., Busuttil, M., VoVan, M. L., Misset, J. L., Lévi, F., Musset, M., Ribaud, P., Hilgard, P., Reissmann, T., Stekar, J., Voegeli, R., Den Otter, W., Maas, H. A., Dullens, H. F. J., Merriman, R. L., Tanzer, L. R., Shackelford, K. A., Bemis, K. G., Campbell, J. B., and Matsumoto, K.

Published
1988
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39. Improvement of the synthesis of immunologic carbohydrate vaccines containing the tumor associated antigen CaMBr1

Author

Panza, L, Poletti, L, PROSPERI, DAVIDE, Canevari, S, Perico, ME, Panza, L, Poletti, L, Prosperi, D, Canevari, S, and Perico, M

Subjects
globo-H, immunologia, CHIM/06 - CHIMICA ORGANICA, MED/04 - PATOLOGIA GENERALE, carbohydrates, conjugate vaccine, antitumorali, CRM197, KLH, sintesi organica, BIO/10 - BIOCHIMICA, complex mixtures
Abstract

The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.

Published
2001

40. In nostro fantastico sistema immuntario

Author

Bonecchi, R., Brembilla, N., Canevari, S., Carsetti, R., Casola, S., Cometa, A., Contento, R., Cossarizza, A., Dander, E., De Berardinis, P., D'Elios, M., Di Bonito, P., Ferlazzo, G., Fraziano, M., Gasparini, C., Italiani, P., Mezzanzanica, D., Morrone, S., Muzio, M., Novelli, Francesco, Paolini, R., Paroli, M., Pellicciotta, I., Piconese, S., Pittoni, P., Prisco, A., Pucillo, C., Ruggiero, G., Sironi, M., Sozzani, S., Triggiani, M., Vecchi, A., and Zocchi, M.

Published
2011

45. Synergistic anti-tumor activity and inhibition of angiogenesis by cotargeting of oncogenic and death receptor pathways in human melanoma

Author

Grazia, G, primary, Vegetti, C, additional, Benigni, F, additional, Penna, I, additional, Perotti, V, additional, Tassi, E, additional, Bersani, I, additional, Nicolini, G, additional, Canevari, S, additional, Carlo-Stella, C, additional, Gianni, A M, additional, Mortarini, R, additional, and Anichini, A, additional

Published
2014
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50. Generazione di nuovi anticorpi anti prostate stem cell antigen (PSCA) e loro caratterizzazione al fine di un futuro utilizzo nella terapia e nella diagnosi dei carcinomi prostatico, pancreatico e della vescica

Author

Fracasso, Giulio, Cremonese, Giorgia, Cingarlini, Sara, Anselmi, Cristina, Giglio, Barbara, Boscaini, Anita, Figini, M., Canevari, S., Pagano, F., Zattoni, Filiberto, Prayer Galetti, T., Cetto, Gianluigi, and Colombatti, Marco

Subjects
PSCA, anticorpi, immunotherapy
Published
2007

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