46 results on '"Caneva M"'
Search Results
2. Bone-Healing Pattern on the Surface of Titanium Implants at Cortical and Marrow Compartments in Two Topographic Sites: an Experimental Study in Rabbits
- Author
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Soto-Peñaloza D, Caneva M, Viña-Almunia J, Martín-de-Llano JJ, Peñarrocha-Oltra D, and Peñarrocha-Diago M
- Published
- 2018
3. Effect on osseointegration of two implant macro-designs:A histomorphometric analysis of bicortically installed implants in different topographic sites of rabbit’s tibiae
- Author
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Soto-Penaloza, D, primary, Caneva, M, additional, Vina-Almunia, J, additional, Martin-de-Llano, JJ, additional, Garcia-Mira, B, additional, Penarrocha-Oltra, D, additional, Botticelli, D, additional, and Penarrocha-Diago, M, additional
- Published
- 2019
- Full Text
- View/download PDF
4. A volumetric 3-D digital analysis of dimensional changes to the alveolar process at implants placed immediately into extraction sockets
- Author
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Szathvary, Isacco, Caneva, M., Bressan, Eriberto, Botticelli, D., and Meneghello, Roberto
- Published
- 2015
5. Flap vs. 'flapless' surgical approach at immediate implants: a histomorphometric study in dogs
- Author
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Caneva, M, Botticelli, D, Salata, La, Souza, Sl, Bressan, Eriberto, and Lang, Np
- Subjects
Dental Implants ,Photomicrography ,Dogs ,Connective Tissue ,Dental Implantation, Endosseous ,Alveolar Process ,Epithelial Attachment ,Gingiva ,Animals ,Dental Abutments ,Tooth Socket ,Surgical Flaps - Abstract
To compare the remodeling of the alveolar process at implants installed immediately into extraction sockets by applying a flap or a "flapless" surgical approach in a dog model.Implants were installed immediately into the distal alveoli of the second mandibular premolars of six Labrador dogs. In one side of the mandible, a full-thickness mucoperiosteal flap was elevated (control site), while contra-laterally, the mucosa was gently dislocated, but not elevated (test site) to disclose the alveolar crest. After 4 months of healing, the animals were sacrificed, ground sections were obtained and a histomorphometric analysis was performed.After 4 months of healing, all implants were integrated (n=6). Both at the test and at the control sites, bone resorption occurred with similar outcomes. The buccal bony crest resorption was 1.7 and 1.5 mm at the control and the test sites, respectively."Flapless" implant placement into extraction sockets did not result in the prevention of alveolar bone resorption and did not affect the dimensional changes of the alveolar process following tooth extraction when compared with the usual placement of implants raising mucoperiosteal flaps.
- Published
- 2010
6. Membro Comitato scientifico del Convegno Europeo Network of umanitarian assistance, 21 Settembre - 1 Ottobre, Roma (relazione S. Ricci: La medicina in aree di crisi)
- Author
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Nicoletti, W. E., Ricci, Serafino, and Caneva, M.
- Published
- 2000
7. Medicina sociale ed emergenze internazionali: indirizzi in tema di formazione per la protezione civile
- Author
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Nicoletti, W., Ricci, Serafino, and Caneva, M.
- Published
- 1998
8. La surveillance prénatale de routine en Europe: comparison de expérience de 9 services de Gynéco-Obstétrique situés dans 8 pays différents
- Author
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Langer, B., Caneva, M. P., Schlaeder, G., Pecorari, D., and Diani, Franco
- Published
- 1997
9. Routine prenatal care in Europe: the comparative experience of nine departments of gynaecology and obstetrics in eight different countries
- Author
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Langer, B., Caneva, M.-P., and Schlaeder, G.
- Published
- 1999
- Full Text
- View/download PDF
10. Aspetti della normativa nazionale in fatto di protezione civile
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Nicoletti, W., Amendola, R., Caneva, M., Chiota, G., and Ricci, Serafino
- Published
- 1988
11. Clinical evaluation of a novel dental implant system as single implants under immediate loading conditions - 4-month post-loading results from a multicentre randomised controlled trial
- Author
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Esposito M, Trullenque-Eriksson A, Blasone R, Malaguti G, Gaffuri C, Caneva M, Minciarelli A, and Giuseppe Luongo
12. Low Arousal Threshold Estimation Predicts Failure of Mandibular Advancement Devices in Obstructive Sleep Apnea Syndrome
- Author
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Caterina Antonaglia, Gabriele Vidoni, Luca Contardo, Fabiola Giudici, Francesco Salton, Barbara Ruaro, Marco Confalonieri, Martina Caneva, Antonaglia, C., Vidoni, G., Contardo, L., Giudici, F., Salton, F., Ruaro, B., Confalonieri, M., and Caneva, M
- Subjects
mandibular advancement devices (MADs) ,low arousal threshold (low ArTH) ,obstructive sleep apnea syndrome (OSAS) ,Clinical Biochemistry - Abstract
Introduction: The treatment of choice for obstructive sleep apnea syndrome (OSAS) is continuous positive airway pressure (CPAP). However, CPAP is usually poorly tolerated and mandibular advancement devices (MADs) are an alternative innovative therapeutic approach. Uncertainty still remains as to the most suitable candidates for MAD. Herein, it is hypothesized that the presence of low arousal threshold (low ArTH) could be predictive of MAD treatment failure. Methods: A total of 32 consecutive patients, with OSAS of any severity, who preferred an alternate therapy to CPAP, were treated with a tailored MAD aimed at obtaining 50% of their maximal mandibular advancement. Treatment response after 6 months of therapy was defined as AHI < 5 events per hour or a reduction of AHI ≥ 50% from baseline. Low ArTH was predicted based on the following polysomnography features, as previously shown by Edwards et al.: an AHI of 82.5% and a hypopnea fraction of total respiratory events of >58.3%. Results: There were 25 (78.1%) responders (p-value < 0.01) at 6 months. Thirteen patients (40.6%) in the non-severe group reached AHI lower than 5 events per hour. MAD treatment significantly reduced the median AHI in all patients from a median value of 22.5 to 6.5 (74.7% of reduction, p-value < 0.001). The mandibular advancement device reduced AHI, whatever the disease severity. A significant higher reduction of Delta AHI, after 6 months of treatment, was found for patients without low ArTH. Conclusions: Low ArTH at baseline was associated with a poorer response to MAD treatment and a lower AHI reduction at 6 months. A non-invasive assessment of Low ArTH can be performed through the Edwards’ score, which could help to identify an endotype with a lower predicted response to oral appliances in a clinical setting.
- Published
- 2022
- Full Text
- View/download PDF
13. Suicide and suicides attempts in Italian prison epidemiological findings from the 'Triveneto' area, 2010–2016
- Author
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Matteo Balestrieri, Sara Gambino, Leonardo Egidi, Aldo Mariotto, Diego De Leo, Giulio Castelpietra, Lisa Marzano, Marina Caneva, Tamara Feresin, Castelpietra, G., Egidi, L., Caneva, M., Gambino, S., Feresin, T., Mariotto, A., Balestrieri, M., De Leo, D., and Marzano, L.
- Subjects
Male ,Databases, Factual ,Prison ,Suicide, Attempted ,Suicide prevention ,0302 clinical medicine ,Risk Factors ,Epidemiology ,Suicide attempt ,030212 general & internal medicine ,Young adult ,media_common ,Inmate ,Italy ,Suicide ,Adolescent ,Adult ,Age Distribution ,Female ,Geography ,Humans ,Middle Aged ,Prisoners ,Prisons ,Regression Analysis ,Self-Injurious Behavior ,Sex Distribution ,Young Adult ,Place of birth ,Psychiatry and Mental health ,Human ,medicine.medical_specialty ,media_common.quotation_subject ,Regression Analysi ,Pathology and Forensic Medicine ,03 medical and health sciences ,Databases ,medicine ,Psychiatry ,Factual ,Attempted ,Prison overcrowding ,Risk Factor ,Prisoner ,030227 psychiatry ,Observational study ,Law - Abstract
The aim of this observational study was to assess rates of suicide and suicide attempts, in relation to gender, age, place of birth and security levels, in north-eastern Italian prisons during 2010-2016, and investigate associations with prison overcrowding, offence type and prior self-harm and suicide attempts. The study was based on individual data on suicides and suicide attempts from 16 prisons, with an average yearly number of 3,900 inmates during the study period, for all prisons combined. Descriptive and binomial regression analyses were performed. \ud Rates of suicide and suicide attempts in Triveneto prisons were 1and 15 per 1,000 inmates, respectively. More than 90% of suicides and suicide attempters were men aged between 21 and 49 years old, and most had committed violent offences. Only half the prisoners who died by suicide and 30% of those who made a suicide attempt in custody were Italians. ‘Cooperative witnesses’ had the highest mean suicide attempt rate (30/1,000 inmates). Fourteen per cent of suicides and 19% of attempters had a prior history of suicide attempts and self-injury. In binomial regression analyses, predictors of suicidal behaviour were being a male inmate in standard security conditions, with a mean age of 30 years. \ud The study highlighted that there is a need for suicide prevention policies in Triveneto; these should take into account predictors of suicidal behaviours and individual characteristics of suicidal inmates. More research is warranted in order to both evaluate the effectiveness of prevention plans and better assess risk of suicide in specific groups, such as cooperative witnesses.
- Published
- 2018
14. Effetti di zinco e rame sull'espressione delle metallotioneine e sul contenuto di poliammine in Populus alba L. in micropropagazione
- Author
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BIONDI, STEFANIA, FRANCHIN, CINZIA, ZIOSI, VANINA, TORRIGIANI, PATRIZIA, Fossati T., Pasquini E., Castiglione S., G. VENTURELLA, M: ALEFFI, M. BIGAZZI, G: CANEVA, M. MARIOTTI, Biondi S., Franchin C., Fossati T., Pasquini E., Ziosi V., Torrigiani P., and Castiglione S.
- Subjects
METALLOTIONEINE ,PIOPPO ,METALLI PESANTI ,ESPRESSIONE GENICA ,POLIAMMINE - Abstract
Effetti di zinco e rame sull’espressione genica delle metallotioneine e sul contenuto di poliammine in Populus alba L. in micropropagazione S. BIONDI1, C. FRANCHIN1, T. FOSSATI2, E. PASQUINI1, V. ZIOSI1, P. TORRIGIANI1, S. CASTIGLIONE2, 1 Dipartimento di Biologia, Università di Bologna, Via Irnerio 42, 40126 Bologna; 2 Dipartimento di Biologia, Università di Milano, via Celoria 26, 20133 Milano Vi sono molte evidenze a favore di un possibile coinvolgimento delle metallotioneine (MT) nelle risposte a stimoli ambientali, in particolare si ipotizza che queste proteine siano strettamente correlate alla capacità di molti organismi di tollerare dosi elevate di metalli pesanti. Nelle piante le MT sono classificate in quattro classi (COBBETT, GOLDSBROUGH, 2002)) e in Arabidopsis, pomodoro e cotone vi sono famiglie geniche di MT (ZHOU & GOLDSBROUGH, 1994; GIRITCH et al., 1998; HUDSPETH et al., 1996). Per chiarire le funzioni delle MT nelle piante, sono stati effettuati numerosi studi sull’espressione di questi geni sia durante lo sviluppo che in risposta a stress biotico e abiotico con risultati ancora contrastanti. Pertanto informazioni certe sull’attività endogena delle MT non sono ancora state raggiunte e il loro ruolo rimane elusivo. Nei vegetali le poliammine (PA) si accumulano in risposta a vari stimoli biotici e abiotici (BOUCHEREAU et al., 1999), compresi gli inquinanti ambientali quali i metalli pesanti (WEINSTEIN et al., 1986; HAUSCHILD, 1993). Esse svolgono probabilmente un ruolo nella resistenza allo stress ossidativo, stabilizzando gli acidi nucleici e le membrane biologiche. Il rapido accrescimento, l’elevata produzione di biomassa, l’apparato radicale esteso, la facile propagazione vegetativa e la possiblità di utilizzo nelle coltivazioni a breve rotazione fanno del pioppo un ottimo candidato come pianta arborea da usare nel fitorisanamento di siti inquinati. Tuttavia, sono molte scarse le informazioni circa le sue capacità di accumulo e di tolleranza nei confronti dei metalli. Inoltre, il pioppo è di recente assurto a “pianta arborea modello” in quanto il suo genoma è stato interamente sequenziato, aprendo la via a studi molecolari di ampio respiro (TUSKAN et al., 2004). Nel presente lavoro, è stata esaminata la risposta di un clone commerciale di Populus alba, la cv Villafranca, allevato in vitro attraverso la micropropagazione ed esposto per tempi diversi, fino a un massimo di 15 giorni, a dosi elevate di ZnSO4 o CuCl2. Sono stati valutati i sintomi visivi di tossicità, i livelli endogeni di poliammine libere e coniugate, e i livelli di trascritto di tre geni codificanti MT (MT1, MT2 e MT3). I risultati hanno evidenziato un’evidente clorosi fogliare già dopo 1 giorno in piante esposte a concentrazioni di Zn di 1, 2 e 4 mM, ma non 0.5 mM. Un forte ingiallimento e senescenza delle foglie si osservava soltanto con le due dosi più alte a partire dal 7° giorno. Tali sintomi di tossicità, associati a un calo significativo nel contenuto di clorofille, si palesavano in piante trattate con Cu anche a concentrazioni molto più basse (0.1 mM). La formazione di radici avventizie sui germogli trattati con Zn era inibita in maniera dose dipendente, arrivando fino al 50%. Al contrario, in presenza di Cu la rizogenesi era totalmente inibita a partire dalla concentrazione 0,1 mM e fortemente ridotta anche a dosi molto più basse (5 mM). Pur essendo già noto l’effetto fortemente inibente del Cu sulla crescita radicale (MURPHY & TAIZ, 1995) i dati mostrano che anche la rizogenesi è molto sensibile alla tossicità di questo metallo. Del resto, il Cu è uno dei metalli più tossici conosciuti. Nel suolo, la sua biodisponibilità è bassa, ma in soluzione acquosa la sua tossicità viene messa in evidenza provocando stress ossidativo (FERNANDES & HENRIQUES, 1991). Come riportato in Figura 1, il contenuto totale di PA, sia libere che coniugate, misurate dopo 15 giorni di esposizione a tre diverse concentrazioni di Zn (0,5, 1 e 2 mM) ...
- Published
- 2005
15. Piante della medicina tradizionale: aspetti etnobotanici, fitochimici e biotecnologici
- Author
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POLI, FERRUCCIO, SCARTEZZINI, PAOLO, ANTOGNONI, FABIANA, BIONDI, STEFANIA, G. VENTURELLA, M. ALEFFI, M. BIGAZZI, G. CANEVA, M. MARIOTTI, F. Poli, Scartezzini P., F. Antognoni, and S. Biondi
- Published
- 2005
16. Illness experience and (unmet) needs of women with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH): a qualitative analysis of an online forum.
- Author
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Di Mattei VE, Taranto P, Perego G, Caneva M, Parma M, Fontana E, Candiani M, and Montali L
- Abstract
Objective: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital condition characterized by the underdevelopment or complete absence of the uterus and the upper part of the vagina. Diagnosis is commonly made during adolescence, a sensitive period for psychophysical development, following the absence of menstruation. Having MRKH syndrome can have a profound and multifaceted psychosocial impact that characterizes these women's subjective experiences, although it continues to be qualitatively understudied. This article explores the lived experience of women with MRKH spontaneously recounted on an online support forum. The aim was to gain insight into the features of the syndrome experience to understand deeply the emotional and social impact of the condition and the individual needs expressed online., Methods: Using a naturalistic observation stance, data was collected from an online support forum for MRKH women and systematically analyzed using thematic analysis., Results: Four main interconnected themes are identified: the impact of being diagnosed with MRKH, the difficult interaction with the medical environment, challenging social relationships, and the unmet needs of MRKH women., Conclusion: A multidisciplinary and person-centered approach that provides effective and sensitive management of the condition and its psychosocial implications, is essential. Recommendations for future research and practical clinical implications for healthcare professionals are proposed.
- Published
- 2024
- Full Text
- View/download PDF
17. Low Arousal Threshold Estimation Predicts Failure of Mandibular Advancement Devices in Obstructive Sleep Apnea Syndrome.
- Author
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Antonaglia C, Vidoni G, Contardo L, Giudici F, Salton F, Ruaro B, Confalonieri M, and Caneva M
- Abstract
Introduction: The treatment of choice for obstructive sleep apnea syndrome (OSAS) is continuous positive airway pressure (CPAP). However, CPAP is usually poorly tolerated and mandibular advancement devices (MADs) are an alternative innovative therapeutic approach. Uncertainty still remains as to the most suitable candidates for MAD. Herein, it is hypothesized that the presence of low arousal threshold (low ArTH) could be predictive of MAD treatment failure. Methods: A total of 32 consecutive patients, with OSAS of any severity, who preferred an alternate therapy to CPAP, were treated with a tailored MAD aimed at obtaining 50% of their maximal mandibular advancement. Treatment response after 6 months of therapy was defined as AHI < 5 events per hour or a reduction of AHI ≥ 50% from baseline. Low ArTH was predicted based on the following polysomnography features, as previously shown by Edwards et al.: an AHI of 82.5% and a hypopnea fraction of total respiratory events of >58.3%. Results: There were 25 (78.1%) responders (p-value < 0.01) at 6 months. Thirteen patients (40.6%) in the non-severe group reached AHI lower than 5 events per hour. MAD treatment significantly reduced the median AHI in all patients from a median value of 22.5 to 6.5 (74.7% of reduction, p-value < 0.001). The mandibular advancement device reduced AHI, whatever the disease severity. A significant higher reduction of Delta AHI, after 6 months of treatment, was found for patients without low ArTH. Conclusions: Low ArTH at baseline was associated with a poorer response to MAD treatment and a lower AHI reduction at 6 months. A non-invasive assessment of Low ArTH can be performed through the Edwards’ score, which could help to identify an endotype with a lower predicted response to oral appliances in a clinical setting.
- Published
- 2022
- Full Text
- View/download PDF
18. Suicide and suicides attempts in Italian prison epidemiological findings from the "Triveneto" area, 2010-2016.
- Author
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Castelpietra G, Egidi L, Caneva M, Gambino S, Feresin T, Mariotto A, Balestrieri M, De Leo D, and Marzano L
- Subjects
- Adolescent, Adult, Age Distribution, Databases, Factual, Female, Geography, Humans, Italy epidemiology, Male, Middle Aged, Prisons, Regression Analysis, Risk Factors, Self-Injurious Behavior epidemiology, Self-Injurious Behavior psychology, Sex Distribution, Suicide, Attempted statistics & numerical data, Young Adult, Prisoners psychology, Prisoners statistics & numerical data, Suicide psychology, Suicide statistics & numerical data
- Abstract
The aim of this observational study was to assess rates of suicide and suicide attempts, in relation to gender, age, place of birth and security levels, in north-eastern Italian prisons during 2010-2016, and investigate associations with prison overcrowding, offence type and prior self-harm and suicide attempts. The study was based on individual data on suicides and suicide attempts from 16 prisons, with an average yearly number of 3900 inmates during the study period, for all prisons combined. Descriptive and binomial regression analyses were performed. Rates of suicide and suicide attempts in Triveneto prisons were 1and 15 per 1000 inmates, respectively. >90% of suicides and suicide attempters were men aged between 21 and 49 years old, and most had committed violent offenses. Only half the prisoners who died by suicide and 30% of those who made a suicide attempt in custody were Italians. 'Cooperative witnesses' had the highest mean suicide attempt rate (30/1000 inmates). Fourteen per cent of suicides and 19% of attempters had a prior history of suicide attempts and self-injury. In binomial regression analyses, predictors of suicidal behaviour were being a male inmate in standard security conditions, with a mean age of 30 years. The study highlighted that there is a need for suicide prevention policies in Triveneto; these should take into account predictors of suicidal behaviours and individual characteristics of suicidal inmates. More research is warranted in order to both evaluate the effectiveness of prevention plans and better assess risk of suicide in specific groups, such as cooperative witnesses., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
19. Patient-centered rehabilitation of single, partial, and complete edentulism with cemented- or screw-retained fixed dental prosthesis: The First Osstem Advanced Dental Implant Research and Education Center Consensus Conference 2017.
- Author
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Tallarico M, Caneva M, Baldini N, Gatti F, Duvina M, Billi M, Iannello G, Piacentini G, Meloni SM, and Cicciù M
- Abstract
The aim of this consensus conference was to provide clinical guidelines, based on the available evidence and on the author's daily practice and experience, for general dentistry and dental practitioners to allow them to delivery long-term successful restorations. Three groups of expert clinicians and dental technicians were invited to evaluate all of the scientific literature from 1967 up to March 2017 to identify relevant studies on assigned topics and to prepare in advance narrative/systematic review, written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, to fulfill the consensus statement criteria. The three topics assigned to the three groups were abutment/framework materials and customization (metal vs. metal-free restorations), abutment/framework protocols and designs, and abutment/framework retentions (cemented- vs. screw-retained implant-supported prostheses). All the expert clinicians presented their results, and the lectures were followed by discussions. No significant differences in clinical parameters (marginal bone loss, bleeding on probing, and pocket probing depth) between screw- or cemented-retained were found for single and multiple implant-supported restorations. There is moderate evidence that nonoriginal abutments provide worse mechanical behavior than originals and high evidence that different implant neck designs do not offer any clinical or radiographic advantage. All the participants agreed that it is desirable to connect and remove abutments as few times as possible. There is medium evidence that an adequate platform switching tends to enhance tissue volume and stability in the medium- and long-term follow-up. No statistically significant differences exist between metal and zirconia as a framework material. The authors discussed and all agreed that retrievability and patient's expectation (function and esthetics) should guide the choice of the most adequate technique, component, and material., Competing Interests: There are no conflicts of interest.
- Published
- 2018
- Full Text
- View/download PDF
20. Survival and Success Rates of Different Shoulder Designs: A Systematic Review of the Literature.
- Author
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Tallarico M, Caneva M, Meloni SM, Xhanari E, Omori Y, and Canullo L
- Abstract
Objectives: To identify whether there is a relationship between different implant shoulder positions/orientations/designs and prosthetic and/or implant failures, biological or mechanical complications, radiographic marginal bone loss (MBL), peri-implant buccal recession (RC), aesthetic scores (Papilla Index, PES, and WES), and patient satisfaction after a minimum of 1 year function in the aesthetic zone, compared to the two-piece, conventional implant neck architecture., Materials and Methods: The systematic review was written according to the PRISMA guidelines. The search strategy encompassed the English literature from 1967 to September 2016 and was performed online (in the PubMed database of the U.S. National Library of Medicine, Embase, and the Cochrane Library) to identify relevant studies that met the inclusion criteria. The assessment of quality and risk of bias of the selected manuscripts was performed according to the guidelines provided by CONSORT and STROBE statements., Results: A total of 16 articles (7 randomized controlled trials, 4 observational comparative studies, and 5 systematic reviews) were selected to fulfill the inclusion criteria. A trend of higher implant failure and prosthetic complications were experienced in the one-piece group compared to the two-piece group, although no statistically significant differences were found. Higher marginal bone loss was found in the test group (one-piece, scalloped implants) compared to the control group (two-piece, flat implants). No comparative studies reporting data on sloped implants were found that fulfilled the inclusion and exclusion criteria of this systematic review. No differences were experienced between groups regarding aesthetic outcomes and patient satisfaction., Conclusions: There was sufficient evidence that different implant shoulder positions/orientations/designs (scalloped, sloped, and one piece) offer no benefit when compared to two-piece, conventional flat implants. Current evidence is limited due to the quality of available studies.
- Published
- 2018
- Full Text
- View/download PDF
21. Definitive Abutments Placed at Implant Insertion and Never Removed: Is It an Effective Approach? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Author
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Tallarico M, Caneva M, Meloni SM, Xhanari E, Covani U, and Canullo L
- Subjects
- Bone Resorption, Dental Implant-Abutment Design, Humans, Wound Healing, Dental Abutments, Dental Implants, Dental Restoration Failure
- Abstract
Purpose: To assess whether repeated abutment disconnections and reconnections have any impact on peri-implant bone resorption and soft tissue healing., Materials and Methods: Electronic and manual searches were conducted for English-language articles published up to March 2017 that identified a relation between repeated disconnections of implant abutments (PA group) and prosthetic or implant failures, complications, marginal bone loss (MBL), soft tissue healing, and esthetic evaluation (pink esthetic score [PES]) after at least 1 year of function compared with implants receiving a final abutment at the time of implant placement (DA group)., Results: Fourteen articles (535 patients with 994 implants) were selected for qualitative analysis. Six of these were included in the meta-analysis. Five prostheses failed in the PA group and 1 failed in the DA group (P = .1047). Seven biologic complications occurred in the PA group and 6 occurred in the DA group (P = .8121). MBL was significantly less in the DA group (difference, 0.279 mm; P = .000). Greater buccal recession occurred in the PA group (difference, 0.198 mm; P = .0004). The PES evaluation showed no differences between groups (P = .289)., Conclusions: Repeated abutment disconnections and reconnections considerably increased MBL and buccal recession. Further studies are needed to confirm these results., (Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
22. Computer-guided vs freehand placement of immediately loaded dental implants: 5-year postloading results of a randomised controlled trial.
- Author
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Tallarico M, Esposito M, Xhanari E, Caneva M, and Meloni SM
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Time Factors, Treatment Outcome, Immediate Dental Implant Loading methods, Surgery, Computer-Assisted
- Abstract
Purpose: To compare planning and patient rehabilitation using 3D implant planning software and dedicated surgical templates with conventional freehand implant placement for the rehabilitation of partially or fully edentulous patients using flapless or mini-flap procedures and immediate loading., Materials and Methods: Patients requiring at least two implants to be restored with a single prosthesis, having at least 7 mm of bone height and 4 mm in bone width were consecutively enrolled. Patients were randomised according to a parallel group study design into two groups: computerguided group or conventional freehand group. Implants were loaded immediately with a provisional prosthesis, replaced by a definitive prosthesis 4 months later. Outcome measures assessed by a blinded independent assessor were: implant and prosthesis failures, any complications, marginal bone levels, number of treatment sessions, duration of treatment, post-surgical pain and swelling, consumption of pain killers, surgical and prosthetic time, time required to solve complications, and patient satisfaction. Patients were followed up to 5 years after loading., Results: Ten patients (32 implants) were randomised to the computer-guided group and 10 patients (30 implants) were randomised to the freehand group. At the 5-year follow-up examination one patient of the computer-guided group and one of the freehand group dropped-out (both moved to another country). No prostheses failed during the entire follow-up. Two implants failed in the conventional group (6.6%) vs none in the computer-guided group (P = 0.158). Ten patients (five in each group) experienced 11 complications (six in the computer-guided group and five in the freehand group), that were successfully solved. Differences between groups for implant failures and complications were not statistically significant. Five years after loading, the mean marginal bone loss was 0.87 mm ± 0.40 (95% CI: 0.54 to 1.06 mm) in the computer-guided group and 1.29 mm ± 0.31 (95% CI: 1.09 to 1.51 mm) in the freehand group. The difference was statistically significant (difference 0.42 mm ± 0.54; 95% CI: 0.05 to 0.75; P = 0.024). Patient self-reported post-surgical pain (P = 0.037) and swelling (P = 0.007) were found to be statistically significant higher in patients in the freehand group. Number of sessions from patient's recruitment to delivery of the definitive prosthesis, number of days from the initial CBCT scan to implant placement, consumption of painkillers, averaged surgical, prosthetic, and complication times, were not statistically significant different between the groups. At the 5-year followup, all the patients were fully satisfied with the function and aesthetics of their definitive prostheses., Conclusions: Both approaches achieved successful results over the 5-year follow-up period. Statistically higher post-operative pain and swelling were experienced at sites treated freehand with flap elevation. Less marginal bone loss (0.4 mm) was observed in the computer-guided group, at 5 years follow-up., Competing Interests: This trial was completely self-funded and all the authors declare no conflicts of interest.
- Published
- 2018
23. Healing at the interface between recipient sites and autologous block bone grafts affixed by either position or lag screw methods: a histomorphometric study in rabbits.
- Author
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Caneva M, Botticelli D, Carneiro Martins EN, Caneva M, Lang NP, and Xavier SP
- Subjects
- Animals, Osteotomy, Rabbits, Titanium, Transplantation, Autologous, Bone Screws, Mandible surgery, Skull transplantation, Wound Healing
- Abstract
Objective: To compare the sequential healing at the interface gap occurring between autologous bone grafts and recipient sites using two types of fixation techniques., Material and Methods: Twenty-four adult male New Zealand white rabbits were used. Two bone grafts were collected from the calvaria and secured to the lateral aspect of the angle of mandible in each animal. Cortical perforations at the recipient sites were performed. However, no modifications were applied to the graft for its adaptation to the recipient site. Two types of fixation techniques by position or lag screws were applied. This was done by preparing osteotomy holes smaller or larger than the screw diameter, respectively. The animals were sacrificed after 3, 7, 20, and 40 days., Results: After 3 days, the distance between the graft and the recipient site was similar between the two different fixations. Due to the anatomical shapes of the recipient sites and grafts, the distance between the two parts was lower in the central region (<0.1 mm) compared to the external regions of the graft (0.5-0.6 mm). The first evidence of small amounts of new (woven) bone was seen after 7 days, forming from the parent bone. The percentage increased after 20 and 40 days. After 40 days, the grafts were well incorporated within the recipient sites in both groups without any statistically significant difference., Conclusions: The present study did not show superiority of one method over another. A fixation to a recipient site with perforations may be sufficient for incorporating an autologous bone graft even if its adaptation is not perfect and irrespectively of the fixation method. Distances of approximately half millimeter were bridged with newly formed bone., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
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24. Ten-year hard and soft tissue results of a pilot double-blinded randomized controlled trial on immediately loaded post-extractive implants using platform-switching concept.
- Author
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Canullo L, Caneva M, and Tallarico M
- Subjects
- Adult, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Pilot Projects, Prospective Studies, Time Factors, Treatment Outcome, Bone-Implant Interface, Dental Implantation, Endosseous, Gingiva, Immediate Dental Implant Loading methods
- Abstract
Aim: To evaluate the 10-year post-loading radiological and esthetic outcomes of implants inserted in post-extraction sites and restored with or without platform-switching protocol., Material and Methods: Twenty-two patients were scheduled for maxillary post-extractive implant, using a 13 mm in length and 5.5 mm in diameter implant (Global, Sweden & Martina, Padua, Italy). They randomly received definitive restorations using platform-switching concept (abutment 3.8 mm in diameter: test group) or standard restoration (abutment 5.5 mm in diameter: control group). Outcome measures were survival rates of implants and prostheses, peri-implant marginal bone loss and periodontal indices 10 years after prosthetic loading. Moreover, esthetic parameters including soft tissue buccal peri-implant mucosal levels (REC) and mesial and distal papilla height (PH) were taken at definitive restoration, 2 and 10 years thereafter., Results: Nineteen implants were analyzed after 10 years of follow-up. No implants nor prostheses failed. The postoperative radiographs demonstrated an overall mean bone loss of 0.18 ± 0.14 mm in the test group and of 0.80 ± 0.40 mm in the control group (P = 0.00108). Test group showed 0.23 ± 0.51 mm of REC gain and PH was of 0.21 ± 0.33 mm on average. On the other side, the control group presented a REC = -0.59 ± 0.80 mm with PH = -1.12 ± 0.55 mm, demonstrating a slight continuous soft tissue shrinkage during the entire follow-up. The mean values were statistically significant different between test and control group for both REC gain (P = 0.01174) and PH (P = 0.0009)., Conclusions: With the limitations of this study, immediate single implant restorations rehabilitated with platform-switching protocol may provide peri-implant alveolar bone-level stability and avoid continuous soft tissue shrinkage after 10 years of prosthetic loading compared to a platform-matching restoration. Further studies involving larger sample sizes are required to confirm these preliminary results., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
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25. Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans.
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Serrano Méndez CA, Lang NP, Caneva M, Ramírez Lemus G, Mora Solano G, and Botticelli D
- Subjects
- Adult, Allografts pathology, Alveolar Process pathology, Alveolar Process surgery, Animals, Cattle, Female, Heterografts pathology, Humans, Male, Alveolar Ridge Augmentation methods, Bone Transplantation methods
- Abstract
Background: Several types of bone grafts are used in ridge preservation procedures., Purpose: To compare the healing of allografts and xenografts applied for alveolar ridge preservation., Materials and Methods: Twenty volunteers in need of extraction of a single-rooted tooth prior to implant installation were randomized into two groups. One group received a deproteinized cancellous bovine bone xenograft embedded in a 10% collagen matrix and the other a demineralized freeze-dried cortical bone allograft. A collagen membrane was used to cover the grafts, flaps were sutured. At baseline and 6 months later, clinical measurements including vertical and horizontal bone dimensions were taken. Histomorphometric analysis was performed., Results: Both groups showed shrinkage of bone dimensions. At mesial, center and distal sites, the vertical changes in dimension were -0.6, 0.5, and -0.1 mm for the allograft and -1.1, -0.4, and -0.9 mm for the xenograft. The horizontal changes in dimensions were -1.4 mm for the allograft and -2.6 mm for the xenograft. New bone and residual graft material were 25.5 ± 10.1% and 33.8 ± 9.4% at the allograft and 35.3 ± 16.8% and 22.2 ± 13.4% at the xenograft sites. None of the differences was statistically significant., Conclusion: Both grafting materials are suitable for the preservation of the alveolar ridge., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2017
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26. Microbial colonization at the implant-abutment interface and its possible influence on periimplantitis: A systematic review and meta-analysis.
- Author
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Tallarico M, Canullo L, Caneva M, and Özcan M
- Subjects
- Databases, Bibliographic, Gram-Negative Bacteria isolation & purification, Gram-Negative Bacteria pathogenicity, Humans, Bacterial Load, Dental Abutments microbiology, Dental Implant-Abutment Design, Dental Implants microbiology, Peri-Implantitis etiology, Peri-Implantitis microbiology
- Abstract
Purpose: The aim of this systematic review and meta-analysis was to evaluate the microbial colonization at the implant-abutment interfaces (IAI) on bone-level implants and to identify possible association with peri-implant conditions., Study Selection: The focus question aimed to answer whether two-piece osseointegrated implants, in function for at least 1 year, in human, relate to higher bacterial count and the onset of periimplantitis, compared to healthy peri-implant conditions. Search strategy encompassed the on-line (MedLine, Google scholar, Cochrane library) literature from 1990 up to March 2015 published in English using combinations of MeSH (Medical Subject Headings) and search terms. Quality assessment of selected full-text articles was performed according to the ARRIVE and CONSORT statement guidelines. For data analysis, the total bacterial count of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, and Fusobacterium nucleatum was calculated and compared to IAI with or without peri-implant pathology., Results: A total of 14 articles, reporting data from 1126 implants, fulfilled the inclusion criteria and subjected to quality assessment. The selected studies revealed contamination of the IAI, in patients who received two-piece implant systems. Meta-analysis indicated significant difference in total bacterial count between implants affected by periimplantitis versus healthy peri-implant tissues (0.387±0.055; 95% CI 0.279-0.496). Less bacterial counts were identified in the healthy IAI for all the investigated gram-negative bacteria except for T. forsythia., Conclusions: Significantly higher bacterial counts were found for periodontal pathogenic bacteria within the IAI of implants in patients with periimplantitis compared to those implants surrounded by healthy peri-implant tissues., (Copyright © 2017 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
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27. Sinus mucosa elevation using Bio-Oss ® or Gingistat ® collagen sponge: an experimental study in rabbits.
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Caneva M, Lang NP, Garcia Rangel IJ, Ferreira S, Caneva M, De Santis E, and Botticelli D
- Subjects
- Animals, Osteogenesis, Rabbits, Wound Healing drug effects, Bone Substitutes pharmacology, Collagen pharmacology, Minerals pharmacology, Sinus Floor Augmentation methods
- Abstract
Objective: To describe the sequential healing in augmented sinus cavities with deproteinized bovine bone mineral (DBBM) granules or collagen sponges., Material and Methods: Twenty albino New Zealand rabbits were included in the study. An incision was performed along the midline of the nasal dorsum, and the nasal bone was exposed. Circular bony windows with a diameter of 5 mm were prepared bilaterally. After elevation of the mucosa, the two sites were randomly filled with either DBBM or a collagen sponge. Five animals each were randomly sacrificed after 7, 14, 21 and 40 days, respectively., Results: At both sides, new bone was found forming from the resident pristine bone. During the first stage of healing, DBBM granules were surrounded by a denser connective tissue that was attached to the biomaterial surface and that was progressively mineralized. At the collagen sponge side, the biomaterial was almost completely resorbed and the space was reduced by to two-thirds already after 21 days. At both sides, after 40 days, mineralized bone and marrow spaces were occupying large areas of the elevated space., Conclusions: New bone was found forming from the pristine bony walls of the sinus and extending toward the most peripheral regions in both sites. While DBBM particles yielded osteoconductivity and were able to preserve over time the space within the elevated mucosa, the collagen sponge failed the goal of maintaining the space., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
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28. Healing at implants installed concurrently to maxillary sinus floor elevation with Bio-Oss ® or autologous bone grafts. A histo-morphometric study in rabbits.
- Author
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De Santis E, Lang NP, Ferreira S, Rangel Garcia I Jr, Caneva M, and Botticelli D
- Subjects
- Animals, Bone-Implant Interface pathology, Osseointegration, Rabbits, Tibia transplantation, Bone Substitutes therapeutic use, Bone Transplantation methods, Dental Implantation, Endosseous methods, Minerals therapeutic use, Sinus Floor Augmentation methods
- Abstract
Objective: To compare the healing at elevated sinus floors augmented either with deproteinized bovine bone mineral (DBBM) or autologous bone grafts and followed by immediate implant installation., Material and Methods: Twelve albino New Zealand rabbits were used. Incisions were performed along the midline of the nasal dorsum. The nasal bone was exposed. A circular bony widow with a diameter of 3 mm was prepared bilaterally, and the sinus mucosa was detached. Autologous bone (AB) grafts were collected from the tibia. Similar amounts of AB or DBBM granules were placed below the sinus mucosa. An implant with a moderately rough surface was installed into the elevated sinus bilaterally. The animals were sacrificed after 7 (n = 6) or 40 days (n = 6)., Results: The dimensions of the elevated sinus space at the DBBM sites were maintained, while at the AB sites, a loss of 2/3 was observed between 7 and 40 days of healing. The implants showed similar degrees of osseointegration after 7 (7.1 ± 1.7%; 9.9 ± 4.5%) and 40 days (37.8 ± 15%; 36.0 ± 11.4%) at the DBBM and AB sites, respectively. Similar amounts of newly formed mineralized bone were found in the elevated space after 7 days at the DBBM (7.8 ± 6.6%) and AB (7.2 ± 6.0%) sites while, after 40 days, a higher percentage of bone was found at AB (56.7 ± 8.8%) compared to DBBM (40.3 ± 7.5%) sites., Conclusions: Both Bio-Oss
® granules and autologous bone grafts contributed to the healing at implants installed immediately in elevated sinus sites in rabbits. Bio-Oss® maintained the dimensions, while autologous bone sites lost 2/3 of the volume between the two periods of observation., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)- Published
- 2017
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29. Five-Year Results of a Randomized Controlled Trial Comparing Patients Rehabilitated with Immediately Loaded Maxillary Cross-Arch Fixed Dental Prosthesis Supported by Four or Six Implants Placed Using Guided Surgery.
- Author
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Tallarico M, Meloni SM, Canullo L, Caneva M, and Polizzi G
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Treatment Outcome, Dental Implants, Dental Prosthesis
- Abstract
Purpose: To compare the 5-year clinical and radiological outcomes of patients rehabilitated with four or six implants placed using guided surgery and immediate function concept., Materials and Methods: Forty patients randomly received four (All-on-4) or six (All-on-6) immediately loaded implants, placed using guided surgery, to support a cross-arch fixed dental prosthesis. Outcome measures were survival rates of implants and prostheses, complications, peri-implant marginal bone loss, and periodontal parameters., Results: No drop-out occurred. Seven implants failed at the 5-year follow-up examination: six in the All-on-6 group (5%) and one in the All-on-4 group (1.25%), with no statistically significant differences (p = .246). No prosthetic failure occurred. Both group experienced some technical and biologic complications with no statistically significant differences between groups (p = .501). All-on-4 treatment concept demonstrated a trend of more complications during the entire follow-up period. A trend of more implant failure was experienced for the All-on-6 treatment concept. Marginal bone loss (MBL) from baseline to the 5-year follow-up was not statistically different between All-on-4 (1.71 ± 0.42 mm) and All-on-6 (1.51 ± 0.36 mm) groups (p = .12). For periodontal parameters, there were no differences between groups (p > .05)., Conclusion: Both approaches may represent a predictable treatment option for the rehabilitation of complete edentulous patients in the medium term. Longer randomized controlled studies are needed to confirm these results., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2016
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30. Clinical evaluation of a novel dental implant system as single implants under immediate loading conditions - 4-month post-loading results from a multicentre randomised controlled trial.
- Author
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Esposito M, Trullenque-Eriksson A, Blasone R, Malaguti G, Gaffuri C, Caneva M, Minciarelli A, and Luongo G
- Subjects
- Crowns, Dental Prosthesis Design, Humans, Time Factors, Dental Implants, Immediate Dental Implant Loading
- Abstract
Purpose: To evaluate the safety and clinical effectiveness of a novel dental implant system (GENESIS Implant System, Keystone Dental, Massachusetts, USA) using another dental implant system by the same manufacturer as a control (PRIMA Implant System, Keystone Dental)., Materials and Methods: A total of 53 patients requiring at least two single crowns had their sites randomised according to a split-mouth design to receive both implant systems at six centres. If implants could be placed with a torque superior to 40 Ncm they were to be loaded immediately with provisional crowns, otherwise after 3 months of submerged healing. Provisional crowns were replaced by definitive crowns 4 months after initial loading, when the follow-up period for the initial part of this study was completed. Outcome measures were crown/implant failures, complications, pink esthetic score (PES), peri-implant marginal bone level changes, plaque score, marginal bleeding, patients and preference of the clinician., Results: In total 53 PRIMA and 53 GENESIS implants were placed. Three patients dropped out but all of the remaining patients were followed up to 4-months post-loading. No PRIMA implant failed whereas four GENESIS implants failed. Only two complications were reported for PRIMA implants. There were no statistically significant differences for crown/implant failures (difference in proportions = 0.080; P (McNemar test) = 0.125) and complications (difference in proportions = -0.04; P (McNemar test) = 0.500) between the implant systems. There were no differences at 4-months post-loading for plaque (difference = -0.54, 95% CI: -3.01 to 1.93; P (Paired t-test) = 0.660), marginal bleeding (difference = -3.8, 95% CI: -7.63 to 0.019; P (Paired t-test) = 0.051), PES (difference = 0.47, 95% CI: -0.56 to 1.50; P (Paired t-test) = 0.365) and marginal bone level changes (difference in mm = -0.04, 95% CI: -0.33 to 0.26; P (Paired t-test) = 0.795). The majority of the patients (46) had no preference regarding the two implant systems evaluated. Three operators preferred GENESIS implants, two had no preference and one preferred GENESIS in medium and soft bone and PRIMA in hard bone., Conclusions: No statistically significant differences were observed between the systems' implant types, although four GENESIS implants failed versus none of the PRIMA type. Longer follow-ups of wider patient populations are needed to better understand whether there is an effective advantage with one of the two implant designs. Conflict-of-interest statement: This research project was originally funded by Keystone Italia, Dental spa (Verona, Italy), the manufacturer of the implants evaluated in this investigation. However, when Keystone Italia received the data of the present manuscript, they refused to honour the financial agreement for the present publication. Therefore, no further follow-ups of this trial will be considered. A legal action was initiated against Keystone Italia. The data belonged to the authors and by no means was the manufacturer allowed to interfere with the conduct of the trial or the publication of the results.
- Published
- 2016
31. Bone healing at bicortically installed implants with different surface configurations. An experimental study in rabbits.
- Author
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Caneva M, Lang NP, Calvo Guirado JL, Spriano S, Iezzi G, and Botticelli D
- Subjects
- Animals, Dental Prosthesis Design, Microscopy, Electron, Scanning, Osseointegration, Rabbits, Random Allocation, Surface Properties, Tibia surgery, Dental Implantation, Endosseous methods, Dental Implants, Implants, Experimental, Wound Healing physiology
- Abstract
Objective: To study the sequential healing at bicortically installed implants with surface modifications by the use of fluoroboric acid and/or H2 O2 ., Material and Methods: Twenty-eight albino New Zealand rabbits were used. Two recipient sites were prepared in the tibiae bilaterally, one in the metaphysis and the second in the diaphysis regions. Four implants with different surface characteristics were randomly installed with bicortical stabilization: (i) sandblasted and acid-etched; (ii) same surface as i, but with a substitution of the hydrofluoric acid with fluoroboric acid; (iii) same surface as i, additionally treated with H2 O2 ; and (iv) same surface modified as ii, additionally treated with H2 O2 . The animals were killed after 5, 8, 15, and 30 days. Ground sections were prepared for histological analyses., Results: No statistically significant differences in osseointegration were found among various surfaces at any of the healing periods. A higher degree of osseointegration was observed at the implants placed in the metaphysis compared to those placed in the diaphysis, especially during early healing. A higher degree of osseointegration was found at sites with proximity to compact (cortical) bone when compared to the middle portion of the implants, especially in the diaphysis region., Conclusions: Surfaces modified with different acids or H2 O2 resulted in similar osseointegration compared to a standard sandblasted and acid-etched surface. The portion of the bicortically installed implants in close contact with the cortical compartment presented a higher percentage of osseointegration compared with the region in contact with the bone marrow compartment., (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2015
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32. A digital evaluation of alveolar ridge preservation at implants placed immediately into extraction sockets: an experimental study in the dog.
- Author
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Favero G, Lang NP, Romanelli P, Pantani F, Caneva M, and Botticelli D
- Subjects
- Animals, Bicuspid, Dogs, Photography, Tooth Extraction, Tooth Socket surgery, Alveolar Bone Loss prevention & control, Bone Substitutes pharmacology, Collagen pharmacology, Immediate Dental Implant Loading methods, Mandibular Diseases prevention & control, Membranes, Artificial
- Abstract
Objective: To compare with pristine sites bone resorption and soft tissue adaptation at implants placed immediately into extraction sockets (IPIES) in conjunction with deproteinized bovine bone mineral (DBBM) particles and a collagen membrane., Material and Methods: The mesial root of the third premolar in the left side of the mandible was endodontically treated (Test). Flaps were elevated, the tooth hemi-sectioned, and the distal root removed to allow the immediate installation of an implant into the extraction socket in a lingual position. DBBM particles were placed into the defect and on the outer contour of the buccal bony ridge, concomitantly with the placement of a collagen membrane. A non-submerged healing was allowed. The premolar on the right side of the mandible was left in situ (control). Ground sections from the center of the implant as well as from the center of the distal root of the third premolar of the opposite side of the mandible were obtained. The histological image from the implant site was superimposed to that of the contralateral pristine distal alveolus, and dimensional variation evaluated for the hard tissue and the alveolar ridge., Results: After 3 months of healing, both histological and photographic evaluation revealed a reduction of hard and soft tissue dimensions., Conclusion: The contour augmentation performed with DBBM particles and a collagen membrane at the buccal aspects of implants placed IPIES was not able to maintain the tissue volume., (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2015
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33. Comparisons between Bio-Oss(®) and Straumann(®) Bone Ceramic in immediate and staged implant placement in dogs mandible bone defects.
- Author
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Antunes AA, Oliveira Neto P, de Santis E, Caneva M, Botticelli D, and Salata LA
- Subjects
- Alveolar Bone Loss prevention & control, Animals, Bone Transplantation methods, Dogs, Immediate Dental Implant Loading, Male, Wound Healing, Bone Substitutes pharmacology, Dental Enamel Proteins pharmacology, Dental Implantation, Endosseous methods, Dental Implants, Hydroxyapatites pharmacology, Mandible surgery, Minerals pharmacology, Osseointegration
- Abstract
Objective: To compare immediate and staged approach implant placement in circumferential defects treated with deproteinized bovine bone mineral (DBBM); hidroxyapatite/tricalcium phosphate (HA/TP); autogenous bone (Ab); and coagulum (Cg); upon implant stability, osseointegration and alveolar crest maintenance., Materials and Methods: Six dogs underwent extractions of lower premolars, bilaterally. Twelve weeks later four bone defects (6 mm wide/4 mm long) were drilled at one side and randomly filled with DBBM; HA/TP; Ab; and Cg, respectively, and left to heal (staged approach). Eight weeks later one implant (Osseospeed(™) , AstraTech) was placed in experimental sites. At the same session four defects were drilled on contra-lateral side and implants were inserted immediately after biomaterials grafting (immediate approach). Animals were euthanized 8 weeks later. Implant stability was measured by resonance frequency analysis (RFA) at installation and after sacrifice. Ground sections were prepared for bone contact (BIC); bone area (BA); distance implant shoulder-bone crest (IS-C); distance implant shoulder first bone contact (IS-B); and areas occupied by soft tissue., Results: The BA and BIC were superior in the staged approach. The Cg exhibited higher BIC and BA as compared with other materials at the total implant body (P = 0.004 and 0.012, respectively). The DBBM, HA/TP and Ab groups rendered similar BA and BIC. The immediate approach resulted in less crest resorption compared to staged approach. The biomaterials did not affect the IS-C and IS-B measurements. Particles area tended to be higher in DBBM group than HA/TP (P = 0.15), while soft tissue infiltrate was higher in DBBM group when used in the immediate approach (P = 0.04). The RFA indicated gain in stability in the staged approach (P = 0.002). The correlation test between RFA vs. BIC and BA demonstrated inferior stability for DBBM group in immediate approach (P = 0.01)., Conclusions: Implants placed in healed defects resulted in better stability as a consequence of higher BIC and BA. The Cg alone rendered increased BIC compared to other materials in both approaches. Immediate approach should be preferable to staged approach in terms of alveolar crest maintenance. The BIC and BA values did not vary between micro and macro-threads in this experimental model. Implants installed in sites filled with DBBM in immediate approach were less stable., (© 2011 John Wiley & Sons A/S.)
- Published
- 2013
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34. Connective tissue grafts in conjunction with implants installed immediately into extraction sockets. An experimental study in dogs.
- Author
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Caneva M, Botticelli D, Viganò P, Morelli F, Rea M, and Lang NP
- Subjects
- Alveolar Bone Loss prevention & control, Animals, Bicuspid, Dental Implants, Dogs, Mandible surgery, Osseointegration, Surgical Flaps, Connective Tissue transplantation, Immediate Dental Implant Loading, Tooth Extraction, Tooth Socket surgery
- Abstract
Aim: To evaluate the influence of a sub-epithelial connective tissue graft placed at the buccal aspect of implants installed immediately after tooth extraction on the dimensional changes of hard and soft tissues., Materials and Methods: In six Labrador dogs a bilateral partial- thickness dissection was made buccal to the second mandibular premolar. At the lingual aspect, full-thickness flaps were elevated. The teeth were extracted and implants installed immediately into the distal socket. A connective tissue graft was obtained from the palate and applied to the buccal aspect of the test sites, whereas contra-laterally, no graft was applied. The flaps were sutured to allow a non-submerged installation. After 4 months of healing, the animals were sacrificed, ground sections were obtained and histomorphometric analyses were performed., Results: After 4 months of healing, all implants were integrated (n = 6). Both at the test and at the control sites bone resorption occurred: 1.6 mm and 2.1 mm, respectively. The difference was not statistically significant. The coronal aspect of the peri-implant soft tissue was wider and located more coronally at the test compared with the control sites. The differences were statistically significant., Conclusions: The application of a connective tissue graft placed at the buccal aspect of the bony wall at implants installed immediately after tooth extraction yielded a minimal preservation of the hard tissues. The peri-implant mucosa, however, was significantly thicker and more coronally positioned at the test compared with the control sites., (© 2012 John Wiley & Sons A/S.)
- Published
- 2013
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35. Alveolar process preservation at implants installed immediately into extraction sockets using deproteinized bovine bone mineral - an experimental study in dogs.
- Author
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Caneva M, Botticelli D, Morelli F, Cesaretti G, Beolchini M, and Lang NP
- Subjects
- Animals, Bone Resorption, Cattle, Dogs, Osseointegration, Statistics, Nonparametric, Surface Properties, Surgical Flaps, Titanium, Tooth Extraction, Wound Healing, Alveolar Process surgery, Collagen pharmacology, Dental Implants, Immediate Dental Implant Loading methods, Tooth Socket surgery
- Abstract
Aim: To evaluate the soft tissue and the dimensional changes of the alveolar bony crest at sites where deproteinized bovine bone mineral (DBBM) particles, concomitantly with the placement of a collagen membrane, were used at implants installed into sockets immediately after tooth extraction., Material and Methods: The pulp tissue of the mesial roots of (3) P(3) was removed in six Labrador dogs, and the root canals were filled. Flaps were elevated bilaterally, the premolars hemi-sectioned, and the distal roots removed. Recipient sites were prepared in the distal alveolus, and implants were placed. At the test sites, DBBM particles were placed in the residual marginal defects concomitantly with the placement of a collagen membrane. No treatment augmentation was performed at the control sites. A non-submerged healing was allowed. Impressions were obtained at baseline and at the time of sacrifice performed 4 months after surgery. The cast models obtained were analyzed using an optical system to evaluate dimensional variations. Block sections of the implant sites were obtained for histological processing and soft tissue assessments., Results: After 4 months of healing, no differences in soft tissue dimensions were found between the test and control sites based on the histological assessments. The location of the soft tissue at the buccal aspect was, however, more coronal at the test compared with the control sites (1.8 ± 0.8 and 0.9 ± 0.8 mm, respectively). At the three-dimensional evaluation, the margin of the soft tissues at the buccal aspect appeared to be located more apically and lingually. The vertical dislocation was 1 ± 0.6 and 2.7 ± 0.5 mm at the test and control sites, respectively. The area of the buccal shrinkage of the alveolar crest was significantly smaller at the test sites (5.9 ± 2.4 mm(2) ) compared with the control sites (11.5 ± 1.7 mm(2) )., Conclusion: The use of DBBM particles concomitantly with the application of a collagen membrane used at implants placed into sockets immediately after tooth extraction contributed to the preservation of the alveolar process., (© 2011 John Wiley & Sons A/S.)
- Published
- 2012
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36. Influence of implants with different sizes and configurations installed immediately into extraction sockets on peri-implant hard and soft tissues: an experimental study in dogs.
- Author
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Caneva M, Botticelli D, Rossi F, Cardoso LC, Pantani F, and Lang NP
- Subjects
- Animals, Dogs, Osseointegration, Statistics, Nonparametric, Surgical Flaps, Tooth Extraction, Wound Healing, Alveolar Process surgery, Dental Implantation, Endosseous methods, Dental Implants, Single-Tooth, Dental Prosthesis Design, Tooth Socket surgery
- Abstract
Aim: To study the influence on the healing of soft and hard peri-implant tissues when implants of different sizes and configurations were installed into sockets immediately after tooth extraction., Material and Methods: Transmucosal cylindrical implants, 3.3 mm in diameter in the control sites, and conical 5 mm in diameter in the test sites, were installed into the distal socket of the fourth mandibular premolars in dogs immediately after tooth extraction. After 4 months, the hard and soft tissue healing was evaluated histologically., Results: All implants were integrated in mineralized mature bone. Both at the test and control sites, the alveolar crest underwent resorption. The buccal bony surface at the implant test sites (conical; 3.8 mm) was more resorbed compared with the control sites (cylindrical; 1.6 mm). The soft tissue dimensions were similar in both groups. However, in relation to the implant shoulder, the peri-implant mucosa was located more apically at the test compared with the control sites., Conclusion: The present study confirmed that the distance between the implant surface and the outer contour of the buccal alveolar bony crest influenced the degree of resorption of the buccal bone plate. Consequently, in relation to the implant shoulder, the peri-implant mucosa will be established at a more apical level, if the distance between the implant surface and the outer contour of the alveolar crest is small., (© 2011 John Wiley & Sons A/S.)
- Published
- 2012
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37. Deproteinized bovine bone mineral in marginal defects at implants installed immediately into extraction sockets: an experimental study in dogs.
- Author
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Caneva M, Botticelli D, Pantani F, Baffone GM, Rangel IG Jr, and Lang NP
- Subjects
- Animals, Bone Resorption, Dental Abutments, Dogs, Mandible surgery, Osseointegration, Particle Size, Surface Properties, Surgical Flaps, Titanium, Wound Healing, Collagen pharmacology, Dental Implantation, Endosseous methods, Dental Implants, Minerals pharmacology, Tooth Socket surgery
- Abstract
Aim: To evaluate the influence of deproteinized bovine bone mineral (DBBM) particles concomitant with the placement of a collagen membrane on alveolar ridge preservation and on osseointegration of implants placed into alveolar sockets immediately after tooth extraction., Material and Methods: The pulp tissue of the mesial roots of (3) P(3) was removed in six Labrador dogs and the root canals were filled. Flaps were elevated in the right side of the mandible, and the buccal and lingual alveolar bony plates were exposed. The third premolar was hemi-sectioned and the distal root was removed. A recipient site was prepared and an implant was placed lingually. After implant installation, defects of about 0.6 mm wide and 3.1 mm depth resulted at the buccal aspects of the implant, both at the test and at the control sites. The same surgical procedures and measurements were performed on the left side of the mandible. However, DBBM particles with a size of 0.25-1 mm were placed into the remaining defect concomitant with the placement of a collagen membrane., Results: All implants were integrated into mature bone. No residual DBBM particles were detected at the test sites after 4 months of healing. Both the test and the control sites showed buccal alveolar bone resorption, 1.8 ± 1.1 and 2.1 ± 1 mm, respectively. The most coronal bone-to-implant contact at the buccal aspect was 2 ± 1.1 an 2.8 ± 1.3 mm, at the test and the control sites, respectively. This difference in the distance was statistically significant., Conclusion: The application of DBBM concomitant with a collagen membrane to fill the marginal defects around implants placed into the alveolus immediately after tooth extraction contributed to improved bone regeneration in the defects. However, with regard to buccal bony crest preservation, a limited contribution of DBBM particles was achieved., (© 2011 John Wiley & Sons A/S.)
- Published
- 2012
- Full Text
- View/download PDF
38. Magnesium-enriched hydroxyapatite at immediate implants: a histomorphometric study in dogs.
- Author
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Caneva M, Botticelli D, Stellini E, Souza SL, Salata LA, and Lang NP
- Subjects
- Alveolar Bone Loss pathology, Alveolar Process pathology, Animals, Bicuspid surgery, Calcification, Physiologic physiology, Connective Tissue pathology, Dental Implants, Dental Prosthesis Design, Dogs, Mandible pathology, Osseointegration physiology, Surface Properties, Time Factors, Tooth Extraction, Tooth Socket pathology, Biocompatible Materials therapeutic use, Bone Substitutes therapeutic use, Durapatite therapeutic use, Immediate Dental Implant Loading, Magnesium Compounds therapeutic use, Mandible surgery, Tooth Socket surgery
- Abstract
Aim: To evaluate the influence of magnesium-enriched hydroxyapatite (MHA) (SintLife(®)) on bone contour preservation and osseointegration at implants placed immediately into extraction sockets., Material and Methods: In the mandibular pre-molar region, implants were installed immediately into extraction sockets of six Labrador dogs. MHA was placed at test sites, while the control sites did not receive augmentation materials. Implants were intended to heal in a submerged mode. After 4 months of healing, the animals were sacrificed, and ground sections were obtained for histomorphometric evaluation., Results: After 4 months of healing, one control implant was not integrated leaving n=5 test and control implants for evaluation. Both at the test and the control sites, bone resorption occurred. While the most coronal bone-to-implant contact was similar between test and control sites, the alveolar bony crest outline was maintained to a higher degree at the buccal aspect of the test sites (loss: 0.7 mm) compared with the control sites (loss: 1.2 mm), even though this difference did not reach statistical significance., Conclusions: The use of MHA to fill the defect around implants placed into the alveolus immediately after tooth extraction did not contribute significantly to the maintenance of the contours of the buccal alveolar bone crest., (© 2010 John Wiley & Sons A/S.)
- Published
- 2011
- Full Text
- View/download PDF
39. Hard tissue formation adjacent to implants of various size and configuration immediately placed into extraction sockets: an experimental study in dogs.
- Author
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Caneva M, Salata LA, de Souza SS, Bressan E, Botticelli D, and Lang NP
- Subjects
- Alveolar Bone Loss classification, Alveolar Bone Loss pathology, Animals, Bicuspid surgery, Calcification, Physiologic physiology, Dental Abutments, Dental Materials chemistry, Dogs, Mandible pathology, Mandible surgery, Models, Animal, Osseointegration physiology, Surface Properties, Time Factors, Titanium chemistry, Tooth Socket pathology, Wound Healing physiology, Dental Implantation, Endosseous methods, Dental Implants, Dental Prosthesis Design, Osteogenesis physiology, Tooth Extraction, Tooth Socket surgery
- Abstract
Objectives: To evaluate the influence of implant size and configuration on osseointegration in implants immediately placed into extraction sockets., Material and Methods: Implants were installed immediately into extraction sockets in the mandibles of six Labrador dogs. In the control sites, cylindrical transmucosal implants (3.3 mm diameter) were installed, while in the test sites, larger and conical (root formed, 5 mm diameter) implants were installed. After 4 months of healing, the resorptive patterns of the alveolar crest were evaluated histomorphometrically., Results: With one exception, all implants were integrated in mineralized bone, mainly composed of mature lamellar bone. The alveolar crest underwent resorption at the control as well as at the test implants. This resorption was more pronounced at the buccal aspects and significantly greater at the test (2.7+/-0.4 mm) than at the control implants (1.5+/-0.6 mm). However, the control implants were associated with residual defects that were deeper at the lingual than at the buccal aspects, while these defects were virtually absent at test implants., Conclusions: The installment of root formed wide implants immediately into extraction sockets will not prevent the resorption of the alveolar crest. In contrast, this resorption is more marked both at the buccal and lingual aspects of root formed wide than at standard cylindrical implants.
- Published
- 2010
- Full Text
- View/download PDF
40. Collagen membranes at immediate implants: a histomorphometric study in dogs.
- Author
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Caneva M, Botticelli D, Salata LA, Scombatti Souza SL, Carvalho Cardoso L, and Lang NP
- Subjects
- Alveolar Bone Loss classification, Alveolar Bone Loss pathology, Alveolar Process pathology, Animals, Biocompatible Materials, Dental Implantation, Endosseous, Dental Materials chemistry, Dental Prosthesis Design, Dogs, Mandible pathology, Models, Animal, Osseointegration physiology, Surgical Flaps, Surgical Wound Dehiscence etiology, Titanium chemistry, Tooth Socket pathology, Wound Healing physiology, Zirconium chemistry, Absorbable Implants, Collagen, Dental Implants, Mandible surgery, Membranes, Artificial, Tooth Socket surgery
- Abstract
Aim: To evaluate the influence of resorbable membranes on hard tissue alterations and osseointegration at implants placed into extraction sockets in a dog model., Material and Methods: In the mandibular premolar region, implants were installed immediately into the extraction sockets of six Labrador dogs. Collagen-resorbable membranes were placed at the test sites, while the control sites were left uncovered. Implants were intended to heal in a submerged mode. After 4 months of healing, the animals were sacrificed, and ground sections were obtained for histomorphometric evaluation., Results: After 4 months of healing, a control implant was not integrated (n=5). Both at the test and at the control sites, bone resorption occurred. While the most coronal bone-to-implant contact was similar between the test and the control sites, the alveolar bone crest outline was maintained to a higher degree at the buccal aspect of the test sites (loss: 1.7 mm) compared with the control sites (loss: 2.2 mm)., Conclusions: The use of collagen-resorbable membranes at implants immediately placed into extraction sockets contributed to a partial (23%) preservation of the buccal outline of the alveolar process.
- Published
- 2010
- Full Text
- View/download PDF
41. Influence of implant positioning in extraction sockets on osseointegration: histomorphometric analyses in dogs.
- Author
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Caneva M, Salata LA, de Souza SS, Baffone G, Lang NP, and Botticelli D
- Subjects
- Alveolar Process anatomy & histology, Animals, Dental Abutments, Dogs, Surgical Flaps, Tooth Extraction, Wound Healing, Alveolar Process surgery, Dental Implantation, Endosseous methods, Dental Implants, Single-Tooth, Osseointegration, Tooth Socket surgery
- Abstract
Aim: To evaluate the influence of implant positioning into extraction sockets on osseointegration., Material and Methods: Implants were installed immediately into extraction sockets in the mandibles of six Labrador dogs. In the control sites, the implants were positioned in the center of the alveolus, while in the test sites, the implants were positioned 0.8 mm deeper and more lingually. After 4 months of healing, the resorptive patterns of the alveolar crest were evaluated histomorphometrically., Results: All implants were integrated in mineralized bone, mainly composed of mature lamellar bone. The alveolar crest underwent resorption at the control as well as at the test sites. After 4 months of healing, at the buccal aspects of the control and test sites, the location of the implant rough/smooth limit to the alveolar crest was 2 + or - 0.9 mm and 0.6 + or - 0.9 mm, respectively (P<0.05). At the lingual aspect, the bony crest was located 0.4 mm apically and 0.2 mm coronally to the implant rough/smooth limit at the control and test sites, respectively (NS)., Conclusions: From a clinical point of view, implants installed into extraction sockets should be positioned approximately 1 mm deeper than the level of the buccal alveolar crest and in a lingual position in relation to the center of the alveolus in order to reduce or eliminate the exposure above the alveolar crest of the endosseous (rough) portion of the implant.
- Published
- 2010
- Full Text
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42. Routine prenatal care in Europe: the comparative experience of nine departments of gynaecology and obstetrics in eight different countries.
- Author
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Langer B, Caneva MP, and Schlaeder G
- Subjects
- Acquired Immunodeficiency Syndrome diagnosis, Cardiotocography statistics & numerical data, Europe, Female, Glycosuria, Hepatitis B diagnosis, Humans, Physical Examination, Pregnancy, Pregnancy Complications, Infectious diagnosis, Proteinuria, Serologic Tests, Surveys and Questionnaires, Toxoplasmosis diagnosis, Ultrasonography, Prenatal statistics & numerical data, Vagina, Gynecology, Obstetrics, Prenatal Care
- Abstract
Objective: The aim of this study was to compare routine prenatal care in nine European obstetrics and gynaecology departments., Study Design: A survey was performed between October 1992 and November 1993 by means of a questionnaire. The questionnaire comprised 118 questions covering clinical examinations and investigations systematically performed during the pregnancy., Results: The survey revealed a certain number of differences between the types of prenatal care performed by each department. Thus, one notices differences to do the serological testing (toxoplasmosis, AIDS and hepatitis B) at the first visit and in the practice of vaginal examination, systematic ultrasound examination or cardiotocography., Conclusion: The differences observed in the prenatal care furnished are only a reflection of our uncertainties concerning the validity of the various tests used to monitor pregnancies. At a time when financial restrictions impose choices, we consider an evaluation of the efficacy and cost of prenatal care to be essential.
- Published
- 1999
- Full Text
- View/download PDF
43. [Routine prenatal care in Europe: comparison of the experience of nine gynecologic-obstetric services in eight different countries].
- Author
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Langer B, Caneva MP, and Schlaeder G
- Subjects
- Cardiotocography, Diagnostic Tests, Routine, Europe, Female, Humans, Obstetrics and Gynecology Department, Hospital, Physical Examination, Pregnancy, Surveys and Questionnaires, Ultrasonography, Prenatal, Urine microbiology, Vagina, Prenatal Care methods
- Abstract
Objective: The purpose of this study was to compare the routine pre-natal surveillance carried out in nine European Gyneco-Obstetric units., Material and Method: A survey was carried out between October 1992 and November 1993 with the aid of a questionnaire. The questionnaire contained 118 questions covering clinical examinations and explorations undertaken systematically during the first, second and third trimesters and at the end of pregnancy before delivery. To ensure that the replies were accurate, the survey was carried out on the spot in the units concerned with the head of the unit., Results: The survey revealed a certain number of differences in the surveillance carried out in the various units. The units did not all carry out systematic blood tests for toxoplasmosis, AIDS and hepatitis B at the first examination. The same applied to fasting blood glucose and the bacterial culture of the urine. Nor did all the units automatically undertake vaginal examination during the second and third trimesters and the English departments were not all convinced of the need for systematic ultrasound tests. Only five of the nine units undertook routinely cardiotocographic recordings of the fetal heart rate at the end of the pregnancy., Conclusion: The differences observed in the various surveillance procedures simply reflect our uncertainty regarding the different tests we use to monitor pregnancies. At a time when financial constraints are forcing us to make choices, there is an urgent need to assess the effectiveness and the cost of the various elements of our prenatal monitoring.
- Published
- 1997
44. Aftermath of the Armenian earthquake: from emergency aid to cooperation for development.
- Author
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Caneva M and Hacopian A
- Subjects
- Armenia, Humans, Developing Countries, Disasters, Emergency Medical Services, Relief Work
- Published
- 1992
45. Atrial septal aneurysm: echopolycardiographic study.
- Author
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Longhini C, Brunazzi MC, Musacci G, Caneva M, Bandello A, Bolomini L, Barbiero M, Toselli T, and Barbaresi F
- Subjects
- Adult, Aged, Cardiovascular Diseases complications, Echocardiography, Female, Heart Aneurysm complications, Heart Atria physiopathology, Heart Septum physiopathology, Humans, Male, Middle Aged, Movement, Phonocardiography, Heart Aneurysm physiopathology
- Abstract
Atrial septal aneurysm (ASA) with diagnosis during life is a rarely reported anomaly, especially when not associated with other congenital or acquired valvular cardiopathies. Among 4,000 routine echocardiograms, 23 cases of ASA were found (8 men and 14 women, aged 19 to 79 years). Three patients had coronary artery disease, 2 had dilated cardiomyopathy, 2 had systemic hypertension, 11 had mitral valve prolapse and 5 had no other identifiable cardiovascular diseases. Echocardiography revealed various motion patterns of ASA. No phonomechanocardiographic findings were related to the presence of ASA, and no correlation between echographic and phonocardiographic findings was found.
- Published
- 1985
- Full Text
- View/download PDF
46. Idiopathic apical left ventricular aneurysm in hypertrophic cardiomyopathy. Report of 3 cases, and review of the literature.
- Author
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Barbaresi F, Longhini C, Brunazzi C, Caneva M, Cotogni A, Musacci GF, Rigatelli G, and Volta G
- Subjects
- Adult, Cardiomyopathy, Hypertrophic physiopathology, Cineangiography, Electrocardiography, Female, Heart Ventricles, Hemodynamics, Humans, Male, Middle Aged, Myocardium pathology, Radiography, Thoracic, Cardiomyopathy, Hypertrophic complications, Heart Aneurysm etiology
- Abstract
In a review of 160 cases of hypertrophic cardiomyopathy which underwent hemodynamic studies, 3 cases of apical aneurysm of the left ventricle of unidentifiable etiology were found. Bearing in mind the rarity of apical idiopathic left ventricular aneurysms, the authors believe this association with hypertrophic cardiomyopathy is of some interest and point out the possible pathogenetic mechanisms.
- Published
- 1985
- Full Text
- View/download PDF
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