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3. Onset and mortality of Parkinson’s disease in relation to type II diabetes

Author

Pezzoli, Gianni, Cereda, Emanuele, Amami, Paolo, Colosimo, Santo, Barichella, Michela, Sacilotto, Giorgio, Zecchinelli, Anna, Zini, Michela, Ferri, Valentina, Bolliri, Carlotta, Calandrella, Daniela, Bonelli, Maria Grazia, Cereda, Viviana, Reali, Elisa, Caronni, Serena, Cassani, Erica, Canesi, Margherita, del Sorbo, Francesca, Soliveri, Paola, Zecca, Luigi, Klersy, Catherine, Cilia, Roberto, and Isaias, Ioannis U.

Published
2023
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5. Can we add whey protein supplementation in patients with Parkinson's disease without interfering with levodopa response?

Author

Pinelli, Giovanna, Siri, Chiara, Ranghetti, Alessandra, Cereda, Viviana, Maestri, Roberto, and Canesi, Margherita

Subjects
PARKINSON'S disease, DIETARY proteins, MUSCLE mass, WHEY proteins, DIETARY supplements
Abstract

Objective: The main endpoint of the study was to evaluate if a daily intake of whey protein-based dietary supplement causes a worse response to levodopa in people with Parkinson's Disease (PWPD) Background: In PWPD, the competition between large neutral aminoacids and levodopa at intestinal absorption level may interfere with dopaminergic therapy's (DRT) effect; therefore, protein redistribution dietary regimen has been suggested. Many dietary supplementations are available to help people in balancing the protein intake and overcoming muscle mass loss. However, most of the products contain protein and could potentially affect levodopa action in PWPD. Methods: We performed a randomised single blind monocentric study on PWPD admitted in the rehabilitative unit for a 4-week multidisciplined intensive aerobic rehabilitation treatment. All patients received a standard protein redistribution dietary regimen plus a whey protein-based oral formula (N = 26) or Magnesium (N = 25) twice daily for 28 days. Neurological assessment and physical evaluation were conducted before (T0) and after (T1) rehabilitative treatment; DRT was recorded T0 and T1 as well. The delta of changes within groups in neurological (UPDRS III) and physical (TUG, 6 MW) evaluation scales was compared between groups. Results: Groups were comparable at baseline in clinical and demographic data; at T1, both groups showed a decrease in UPDRS III, TUG and 6 MWT and no differences between deltas were found. DRT remained stable in both groups. Conclusions: Our results show that whey protein supplementation does not interfere with DRT's efficacy and can be used in PWPD who need a protein supplementation without restrictions in intake hours. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Posterior reversible encephalopathy syndrome and COVID-19: A series of 6 cases from Lombardy, Italy

Author

Colombo, Antonio, Martinelli Boneschi, Filippo, Beretta, Sandro, Bresolin, Nereo, Versino, Maurizio, Lorusso, Lorenzo, Spagnoli, Diego, Nastasi, Giulia, Vallauri, Davide, Rota, Stefania, Repaci, Maria, Ferrarini, Massimo, Pozzato, Mattia, Princiotta Cariddi, Lucia, Tabaee Damavandi, Payam, Carimati, Federico, Banfi, Paola, Clemenzi, Alessandro, Marelli, Margherita, Giorgianni, Andrea, Vinacci, Gabriele, Mauri, Marco, Melzi, Paola, Di Stefano, Maria, Tetto, Antonio, Canesi, Margherita, and Salmaggi, Andrea

Published
2021
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7. Long-Term Impact of Deep Brain Stimulation in Parkinson's Disease: Does It Affect Rehabilitation Outcomes?

Author

Canesi, Margherita, Lippi, Lorenzo, Rivaroli, Simone, Vavassori, Daniele, Trenti, Marta, Sartorio, Francesco, Meucci, Nicoletta, de Sire, Alessandro, Siri, Chiara, and Invernizzi, Marco

Subjects
DEEP brain stimulation, SUBTHALAMIC nucleus, PARKINSON'S disease, REHABILITATION, AEROBIC exercises, MEDICAL rehabilitation
Abstract

Background and Objectives: Although the growing literature is now focusing on the long-term effects of Deep Brain Stimulation (DBS) in Parkinson's disease (PD), there is still a large gap of knowledge about its long-term implications in rehabilitation. Therefore, this study aimed at investigating the effects of rehabilitation in PD patients years after DBS implantation. Materials and Methods: This retrospective case–control study analyzed records from Moriggia-Pelascini Hospital, Italy from September 2022 to January 2024. Data of PD patients (n = 47) with (DBS group, n = 22) and without (control group, n = 25) DBS were considered. All study participants underwent a daily rehabilitation program lasting four weeks, including warm-up, aerobic exercises, strength training, postural exercises, and proprioceptive activities. The outcomes assessed were the Unified Parkinson's Disease Rating Scale (UPDRS), Berg Balance Scale (BBS), Timed Up and Go (TUG), 6 Min Walk Test (6MWT), and Self-Assessment Parkinson Disease Scale (SPDDS). Results: DBS group showed significant improvements in terms of all outcome measures after the rehabilitation intervention (UPDRS III: −7.0 (−11.5 to −1.0); p = 0.001; UPDRS I II IV: −12.0 (−19.0 to −4.5); p = 0.001; BBS: 7.0 (3.8 to 10.3); p < 0.001; TUG (s): −2.8 (−5.7 to −1.1); p < 0.001; SPDDS: −8 (−13.0 to −4.0); p < 0.001; 6MWT (m): 81 (37.3 to 132.3); p < 0.001). No differences were reported in the between-group analysis (p: NS). Conclusions: This study emphasizes positive rehabilitation effects on PD patients irrespective of DBS status. Further research is essential to elucidate long-term effects of DBS on rehabilitation outcomes of PD patients. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Efficacy and tolerability of bevacizumab in patients with severe Covid-19

Author

Pang, Jiaojiao, Xu, Feng, Aondio, Gianmarco, Li, Yu, Fumagalli, Alberto, Lu, Ming, Valmadre, Giuseppe, Wei, Jie, Bian, Yuan, Canesi, Margherita, Damiani, Giovanni, Zhang, Yuan, Yu, Dexin, Chen, Jun, Ji, Xiang, Sui, Wenhai, Wang, Bailu, Wu, Shuo, Kovacs, Attila, Revera, Miriam, Wang, Hao, Jing, Xu, Zhang, Ying, Chen, Yuguo, and Cao, Yihai

Published
2021
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9. Supplementing Best Care with Specialized Rehabilitation Treatment in Parkinson's Disease: A Retrospective Study by Different Expert Centers.

Author

Ghilardi, Maria Felice, Quartarone, Angelo, Di Rocco, Alessandro, Calabrò, Rocco Salvatore, Luo, Sheng, Liu, Hongliang, Norcini, Monica, Canesi, Margherita, Cian, Veronica, Zarucchi, Marianna, Ortelli, Paola, Volpe, Daniele, Bakdounes, Leila, Castelli, Davide, Di Fonzo, Alessio, Franco, Giulia, Frattini, Emanuele, Avanzino, Laura, Pelosin, Elisa, and Ogliastro, Carla

Subjects
PARKINSON'S disease, COMMUNITY-based programs, REHABILITATION, MOVEMENT disorders, CAREGIVERS, MEDICAL rehabilitation, NEUROLOGISTS
Abstract

Background: This is a retrospective longitudinal study comparing 374 patients with Parkinson's disease (PD) who were treated in centers offering a specialized program of enhanced rehabilitation therapy in addition to expert outpatient care to 387 patients with PD, who only received expert outpatient care at movement disorders centers in Italy. Methods: The data are from subjects recruited in the Parkinson's Outcome Project (POP) at six Italian centers that are part of a multicenter collaboration for care quality improvement (the Fresco Network). The effects were measured with a baseline and a follow-up clinical evaluation of the Timed-Up-and-Go test (TUG), Parkinson's Disease Questionnaire (PDQ-39), and Multidimensional Caregiver Strain Index (MCSI), the number of falls and hospitalizations for any cause. We used a generalized linear mixed model with the dependent variables being the response variable, which included the covariates demographics, evaluation, and treatment variables. Results: We found that the subjects who underwent specialized enhanced rehabilitation had a better motor outcome over time than those who were managed by expert neurologists but had participated in community programs for exercise and other allied health interventions. The greatest effects were seen in patients in the early stages of the disease with a high amount of vigorous exercise per week in the last six months. Similar effects were seen for PDQ39, MCSI, the number of falls, and hospitalization. Conclusions: Long-term benefits to motor function and the quality of life in patients with PD and burden reduction in their caregivers can be achieved through a systematic program of specialized enhanced rehabilitation interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Axial motor clues to identify atypical parkinsonism: A multicentre European cohort study

Author

Østergaard, Karen, Stamelou, Maria, Tolosa, Eduardo, Kostic, Vladimir S., Cortelli, Pietro, Klockgether, Thomas, Dodel, Richard, Abele, Michael, Meissner, Wassilios, Reichmann, Heinz, Lynch, Tim, Slawek, Jaroslaw, Poewe, Werner, Wenning, Gregor K., Klaus Seppi, Mag, Krismer, Florian, Berg, Daniela, Ferreira, Joaquim, Houlden, Henry, Quinn, Niall P., Widner, Håkan, Gerhard, Alexander, Eggert, Karla Maria, Albanese, Alberto, Sorbo, Francesca del, Barone, Paolo, Pellecchia, Maria T., Bloem, Bas, Borm, Carlijn, Djaldetti, Ruth, Berardelli, Alfredo, Colosimo, Carlo, Berciano, Jose, Traykov, Latchezar, Giladi, Nir, Gurevich, Tanya, Rascol, Olivier, Galitzky, Monique, Gasser, Thomas, Borm, Carlijn D.J.M., Seppi, Klaus, Pellecchia, Maria Teresa, Johnsen, Erik L., Sambati, Luisa, Petrović, Igor, Kostić, Vladimir S., Brožová, Hana, Růžička, Evžen, Marti, Maria Jose, Canesi, Margherita, Post, Bart, Nonnekes, Jorik, and Bloem, Bastiaan R.

Published
2018
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12. Dementia in Parkinson's disease: Is male gender a risk factor?

Author

Cereda, Emanuele, Cilia, Roberto, Klersy, Catherine, Siri, Chiara, Pozzi, Beatrice, Reali, Elisa, Colombo, Aurora, Zecchinelli, Anna Lena, Mariani, Claudio Bruno, Tesei, Silvana, Canesi, Margherita, Sacilotto, Giorgio, Meucci, Nicoletta, Zini, Michela, Isaias, Ioannis Ugo, Barichella, Michela, Cassani, Erica, Goldwurm, Stefano, and Pezzoli, Gianni

Published
2016
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13. Correction to: Caregiver burden and its related factors in advanced Parkinson’s disease: data from the PREDICT study

Author

Tessitore, Alessandro, Marano, Pietro, Modugno, Nicola, Pontieri, Francesco E., Tambasco, Nicola, Canesi, Margherita, Latorre, Anna, Lopiano, Leonardo, Sensi, Mariachiara, Quatrale, Rocco, Solla, Paolo, Defazio, Giovanni, Melzi, Gabriella, Costanzo, Anna Maria, Gualberti, Giuliana, di Luzio Paparatti, Umberto, and Antonini, Angelo

Published
2020
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14. Levodopa Equivalent Dose of Safinamide: A Multicenter, Longitudinal, Case–Control Study

Author

Cilia, Roberto, primary, Cereda, Emanuele, additional, Piatti, Marco, additional, Pilotto, Andrea, additional, Magistrelli, Luca, additional, Golfrè Andreasi, Nico, additional, Bonvegna, Salvatore, additional, Contaldi, Elena, additional, Mancini, Francesca, additional, Imbalzano, Gabriele, additional, De Micco, Rosa, additional, Colucci, Fabiana, additional, Braccia, Arianna, additional, Bellini, Gabriele, additional, Brovelli, Francesco, additional, Zangaglia, Roberta, additional, Lazzeri, Giulia, additional, Russillo, Maria Claudia, additional, Olivola, Enrica, additional, Sorbera, Chiara, additional, Cereda, Viviana, additional, Pinto, Patrizia, additional, Sucapane, Patrizia, additional, Gelosa, Giorgio, additional, Meloni, Mario, additional, Pistoia, Francesca, additional, Sessa, Maria, additional, Canesi, Margherita, additional, Modugno, Nicola, additional, Pacchetti, Claudio, additional, Brighina, Laura, additional, Pellecchia, Maria Teresa, additional, Ceravolo, Roberto, additional, Sensi, Mariachiara, additional, Zibetti, Maurizio, additional, Comi, Cristoforo, additional, Padovani, Alessandro, additional, Zecchinelli, Anna L., additional, Di Fonzo, Alessio, additional, Tessitore, Alessandro, additional, Morgante, Francesca, additional, and Eleopra, Roberto, additional

Published
2023
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18. Onset and mortality of Parkinson’s disease in relation to type II diabetes

Author

Pezzoli, Gianni, primary, Cereda, Emanuele, additional, Amami, Paolo, additional, Colosimo, Santo, additional, Barichella, Michela, additional, Sacilotto, Giorgio, additional, Zecchinelli, Anna, additional, Zini, Michela, additional, Ferri, Valentina, additional, Bolliri, Carlotta, additional, Calandrella, Daniela, additional, Bonelli, Maria Grazia, additional, Cereda, Viviana, additional, Reali, Elisa, additional, Caronni, Serena, additional, Cassani, Erica, additional, Canesi, Margherita, additional, del Sorbo, Francesca, additional, Soliveri, Paola, additional, Zecca, Luigi, additional, Klersy, Catherine, additional, Cilia, Roberto, additional, and Isaias, Ioannis U., additional

Published
2022
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20. Cognitive and Neuropsychiatric Features of COVID-19 Patients After Hospital Dismission: An Italian Sample

Author

Cian, Veronica, De Laurenzis, Alessandro, Siri, Chiara, Gusmeroli, Anna, and Canesi, Margherita

Subjects
General Psychology
Abstract

Background and AimsRecent studies suggest cognitive, emotional, and behavioral impairments occur in patients after SARS-CoV-2 infection. However, studies are limited to case reports or case series and, to our knowledge, few of them have control groups. This study aims to assess the prevalence of neuropsychological and neuropsychiatric impairment in patients after hospitalization.MethodsWe enrolled 29 COVID+ patients (M/F: 17/12; age 58.41 ± 10.00 years; education 11.07 ± 3.77 years, 2 left handers) who needed hospitalization but no IC, about 20 days post-dismission, and 29 COVID− healthy matched controls. Neuropsychological and neuropsychiatric assessments were conducted via teleneuropsychology using the following tests: MMSE, CPM47, RAVLT, CDT, Digit-Span Forward/Backward, Verbal fluencies; BDI-II, STAI. People with previous reported cognitive impairment and neurological or psychiatric conditions were excluded. Clinical and demographics were collected. Comparison between groups was conducted using parametric or non-parametric tests according to data distribution (T-test, Mann Withney-U test; Chi-square goodness of fit). Within COVID+ group, we also evaluated the correlation between the cognitive and behavioral assessment scores and clinical variables collected.ResultsAmong COVID+, 62% had at least one pathological test (vs. 13% in COVID−; p = 0.000) and significantly worst performances than COVID− in RAVLT learning (42.55 ± 10.44 vs. 47.9 ± 8.29, p = 0.035), RAVLT recall (8.79 ± 3.13 vs. 10.38 ± 2.19, p = 0.03), and recognition (13.69 ± 1.47 vs. 14.52 ± 0.63, p = 0.07). STAI II was higher in COVID− (32.69 ± 7.66 vs. 39.14 ± 7.7, p = 0.002). Chi-square on dichotomous values (normal/pathological) showed a significant difference between groups in Digit backward test (pathological 7/29 COVID+ vs. 0/29 COVID−; p = 0.005).ConclusionsPatients COVID+ assessed by teleneuropsychology showed a vulnerability in some memory and executive functions (working memory, learning, delayed recall, and recognition). Intriguingly, anxiety was higher in the control group. Our findings therefore confirm the impact of COVID-19 on cognition even in patients who did not need IC. Follow-up is needed to evaluate the evolution of COVID-19-related cognitive deficit.Clinical Trial Registration[ClinicalTrials.gov], identifier [NCT05143320].

Published
2022

25. Safety and Effectiveness of Cell Therapy in Neurodegenerative Diseases: Take-Home Messages From a Pilot Feasibility Phase I Study of Progressive Supranuclear Palsy

Author

Giordano, Rosaria, primary, Canesi, Margherita, additional, Isalberti, Maurizio, additional, Marfia, Giovanni, additional, Campanella, Rolando, additional, Vincenti, Daniele, additional, Cereda, Viviana, additional, Ranghetti, Alessandra, additional, Palmisano, Chiara, additional, Isaias, Ioannis Ugo, additional, Benti, Riccardo, additional, Marotta, Giorgio, additional, Lazzari, Lorenza, additional, Montemurro, Tiziana, additional, Viganò, Mariele, additional, Budelli, Silvia, additional, Montelatici, Elisa, additional, Lavazza, Cristiana, additional, Rivera-Ordaz, Araceli, additional, and Pezzoli, Gianni, additional

Published
2021
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26. Parkinsonʼs disease beyond 20 years

Author

Cilia, Roberto, Cereda, Emanuele, Klersy, Catherine, Canesi, Margherita, Zecchinelli, Anna L, Mariani, Claudio B, Tesei, Silvana, Sacilotto, Giorgio, Meucci, Nicoletta, Zini, Michela, Ruffmann, Claudio, Isaias, Ioannis U, Goldwurm, Stefano, and Pezzoli, Gianni

Published
2015
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28. Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease

Author

Kalia, Lorraine V., Lang, Anthony E., Hazrati, Lili-Naz, Fujioka, Shinsuke, Wszolek, Zbigniew K., Dickson, Dennis W., Ross, Owen A., Van Deerlin, Vivianna M., Trojanowski, John Q., Hurtig, Howard I., Alcalay, Roy N., Marder, Karen S., Clark, Lorraine N., Gaig, Carles, Tolosa, Eduardo, Ruiz-Martínez, Javier, Marti-Masso, Jose F., Ferrer, Isidre, de Munain, Adolfo López, Goldman, Samuel M., Schüle, Birgitt, Langston, William J., Aasly, Jan O., Giordana, Maria T., Bonifati, Vincenzo, Puschmann, Andreas, Canesi, Margherita, Pezzoli, Gianni, De Paula, Andre Maues, Hasegawa, Kazuko, Duyckaerts, Charles, Brice, Alexis, Stoessl, Jon A., and Marras, Connie

Published
2015
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29. Validation of the Italian version of the Movement Disorder Society—Unified Parkinson’s Disease Rating Scale

Author

Antonini, Angelo, Abbruzzese, Giovanni, Ferini-Strambi, Luigi, Tilley, Barbara, Huang, Jing, Stebbins, Glenn T., Goetz, Christopher G., Barone, Paolo, Bandettini di Poggio, Monica, Fabbrini, Giovanni, Di Stasio, Flavio, Tinazzi, Michele, Bovi, Tommaso, Ramat, Silvia, Meoni, Sara, Pezzoli, Gianni, Canesi, Margherita, Martinelli, Paolo, Maria Scaglione, Cesa Lorella, Rossi, Aroldo, Tambasco, Nicola, Santangelo, Gabriella, Picillo, Marina, Morgante, Letterio, Morgante, Francesca, Quatrale, Rocco, Sensi, MariaChiara, Pilleri, Manuela, Biundo, Roberta, Nordera, Giampietro, Caria, Antonella, Pacchetti, Claudio, Zangaglia, Roberta, Lopiano, Leonardo, Zibetti, Maurizio, Zappia, Mario, Nicoletti, Alessandra, Quattrone, Aldo, Salsone, Maria, Cossu, Gianni, Murgia, Daniela, Albanese, Alberto, Del Sorbo, Francesca, and MDS-UPDRS Italian Validation Study Group

Published
2013
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30. Impact of Supporting People with Advanced Parkinson’s Disease on Carer’s Quality of Life and Burden [Corrigendum]

Author

Modugno,Nicola, Antonini,Angelo, Tessitore,Alessandro, Marano,Pietro, Pontieri,Francesco Ernesto, Tambasco,Nicola, Canesi,Margherita, Fabbrini,Giovanni, Sensi,Mariachiara, Quatrale,Rocco, Solla,Paolo, Defazio,Giovanni, Melzi,Gabriella, Gualberti,Giuliana, and Lopiano,Leonardo

Subjects
Neuropsychiatric Disease and Treatment
Abstract

Modugno N, Antonini A, Tessitore A, et al.Neuropsychiatr Dis Treat. 2020;16:2899–2912. The authors have advised that there is an error with the PDcharacteristics in Table 1 on page 2902. The correct table isshown below. The authors apologize for this error. Read the original article

Published
2021

31. Impact of Supporting People with Advanced Parkinson’s Disease on Carer’s Quality of Life and Burden

Author

Modugno,Nicola, Antonini,Angelo, Tessitore,Alessandro, Marano,Pietro, Pontieri,Francesco Ernesto, Tambasco,Nicola, Canesi,Margherita, Fabbrini,Giovanni, Sensi,Mariachiara, Quatrale,Rocco, Solla,Paolo, Defazio,Giovanni, Melzi,Gabriella, Gualberti,Giuliana, and Lopiano,Leonardo

Subjects
Neuropsychiatric Disease and Treatment
Abstract

Nicola Modugno,1 Angelo Antonini,2 Alessandro Tessitore,3 Pietro Marano,4 Francesco Ernesto Pontieri,5,6 Nicola Tambasco,7 Margherita Canesi,8,9 Giovanni Fabbrini,10,11 Mariachiara Sensi,12 Rocco Quatrale,13 Paolo Solla,14 Giovanni Defazio,14 Gabriella Melzi,15 Giuliana Gualberti,15 Leonardo Lopiano16 1Neurology Unit, IRCCS Neuromed, Pozzilli, Italy; 2Parkinson and Movement Disorder Unit, Department of Neuroscience, University of Padua, Padua, Italy; 3Department of Medical and Surgery Sciences, University of Campania, “Luigi Vanvitelli”, Naples, Italy; 4Casa di Cura Madonna del Rosario, Raggruppamento di Riabilitazione, Catania, Italy; 5Department NESMOS, “Sapienza” University, Sant’Andrea Hospital, Roma, Italy; 6IRCCS Fondazione Santa Lucia, Roma, Italy; 7Department of Neurology, Perugia General Hospital and University of Perugia, Perugia, Italy; 8Dipartimento di Riabilitazione Malattia di Parkinson e Disordini del Movimento, Gravi Cerebrolesioni Acquisite, Italia Hospital - Ospedale “Moriggia-Pelascini”, Gravedona ed Uniti, Como, Italy; 9Centro Parkinson e Disordini del Movimento, CTO, G Pini, Milano, Italy; 10Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy; 11IRCCS Neuromed, Pozzilli, Isernia, Italy; 12Neurology Unit, Hospital Sant’Anna, Ferrara, Italy; 13Neurology Unit, Hospital dell’Angelo, Mestre, VE, Italy; 14Neurology Unit, Policlinico Universitario Monserrato, Cagliari, Italy; 15Medical Department, AbbVie Srl, Roma, Italy; 16Department of Neuroscience “Rita Levi Montalcini” University of Torino, Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza di Torino, Torino, ItalyCorrespondence: Gabriella MelziAbbVie Srl, Viale dell’Arte 25, Roma 00144, ItalyTel +39 06928924346Email gabriella.melzi@abbvie.comPurpose: The aim of this study was to assess the burden and the quality of life (QoL) perceived by caregivers assisting advanced Parkinson’s disease (PD) patients.Patients and Methods: Consecutive advanced PD patients treated with levodopa/carbidopa intestinal gel (LCIG) or continuous subcutaneous apomorphine infusion (CSAI) or care as usual (CU) and their care partners were recruited during routine visits according to a cross-sectional design. Caregiver’s distress was assessed by Zarit Burden Interview (ZBI) and a QoL survey to evaluate and understand the burden experienced by care partners during family and working activities.Results: A total of 126 patients (53 LCIG, 19 CSAI and 54 CU) and their care partners were enrolled. The ZBI score boxplot showed that LCIG and CU populations have a similar distribution (ZBI inter-quartile range [IQR] values respectively 18– 42 for LCIG and 19– 43 for CU group), while the CSAI group has a wider score range (IQR 16– 52). Caregivers assisting patients in treatment with LCIG have more time to perform family or household duties (p=0.0022), or to engage in leisure activities (p=0.0073) compared to CU, while no difference was found when compared to CSAI group. Approximately 50% of the care partners showed mood changes in the last 6 months and LCIG and CSAI had less impact on caregiver’s mood compared to CU. Patients treated with LCIG were more independent in taking a bath or shower without assistance and were more able to move and walk without assistance.Conclusion: Care partners of advanced PD patients treated with device-aided therapies have more time for their own life and a better perception of their QoL with a tendency to an improvement of mood compared with those of patients treated with CU.Keywords: advanced Parkinson’s disease, levodopa/carbidopa, intestinal infusion, caregiver burden, quality of life; QoL

Published
2020

32. Parkin analysis in early onset Parkinson's disease

Author

Sironi, Francesca, Primignani, Paola, Zini, Michela, Tunesi, Sara, Ruffmann, Claudio, Ricca, Sara, Brambilla, Tiziana, Antonini, Angelo, Tesei, Silvana, Canesi, Margherita, Zecchinelli, Anna, Mariani, Claudio, Meucci, Nicoletta, Sacilotto, Giorgio, Cilia, Roberto, Isaias, Ioannis U., Garavaglia, Barbara, Ghezzi, Daniele, Travi, Maurizio, Decarli, Adriano, Coviello, Domenico A., Pezzoli, Gianni, and Goldwurm, Stefano

Published
2008
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36. Impact of Supporting People with Advanced Parkinson's Disease on Carer's Quality of Life and Burden

Author

Modugno, Nicola, Antonini, Angelo, Tessitore, Alessandro, Marano, Pietro, Pontieri, Francesco Ernesto, Tambasco, Nicola, Canesi, Margherita, Fabbrini, Giovanni, Sensi, Mariachiara, Quatrale, Rocco, Solla, Paolo, Defazio, Giovanni, Melzi, Gabriella, Gualberti, Giuliana, and Lopiano, Leonardo

Subjects
advanced Parkinson’s disease, caregiver burden, intestinal infusion, QoL, quality of life, levodopa/carbidopa, Original Research
Abstract

Purpose The aim of this study was to assess the burden and the quality of life (QoL) perceived by caregivers assisting advanced Parkinson’s disease (PD) patients. Patients and Methods Consecutive advanced PD patients treated with levodopa/carbidopa intestinal gel (LCIG) or continuous subcutaneous apomorphine infusion (CSAI) or care as usual (CU) and their care partners were recruited during routine visits according to a cross-sectional design. Caregiver’s distress was assessed by Zarit Burden Interview (ZBI) and a QoL survey to evaluate and understand the burden experienced by care partners during family and working activities. Results A total of 126 patients (53 LCIG, 19 CSAI and 54 CU) and their care partners were enrolled. The ZBI score boxplot showed that LCIG and CU populations have a similar distribution (ZBI inter-quartile range [IQR] values respectively 18–42 for LCIG and 19–43 for CU group), while the CSAI group has a wider score range (IQR 16–52). Caregivers assisting patients in treatment with LCIG have more time to perform family or household duties (p=0.0022), or to engage in leisure activities (p=0.0073) compared to CU, while no difference was found when compared to CSAI group. Approximately 50% of the care partners showed mood changes in the last 6 months and LCIG and CSAI had less impact on caregiver’s mood compared to CU. Patients treated with LCIG were more independent in taking a bath or shower without assistance and were more able to move and walk without assistance. Conclusion Care partners of advanced PD patients treated with device-aided therapies have more time for their own life and a better perception of their QoL with a tendency to an improvement of mood compared with those of patients treated with CU.

Published
2020

37. Predictors of COVID-19 outcome in Parkinson's disease

Author

Fasano, A, Elia, A, Dallocchio, C, Canesi, M, Alimonti, D, Sorbera, C, Alonso-Canovas, A, Pezzoli, G, Fasano, Alfonso, Elia, Antonio E, Dallocchio, Carlo, Canesi, Margherita, Alimonti, Dario, Sorbera, Chiara, Alonso-Canovas, Araceli, Pezzoli, Gianni, Fasano, A, Elia, A, Dallocchio, C, Canesi, M, Alimonti, D, Sorbera, C, Alonso-Canovas, A, Pezzoli, G, Fasano, Alfonso, Elia, Antonio E, Dallocchio, Carlo, Canesi, Margherita, Alimonti, Dario, Sorbera, Chiara, Alonso-Canovas, Araceli, and Pezzoli, Gianni

Abstract

Introduction: Specific pre-existing medical conditions (e.g. hypertension or obesity), advanced age and male sex appear linked to more severe manifestations of SARS Co-V2 infection, thus raising the question of whether Parkinson's disease (PD) poses an increased risk of morbidity and mortality in COVID-19 patients. Methods: In order to describe the outcome of COVID-19 in multi-centre a cohort of PD patients and explore its potential predictors, we gathered the clinical information of 117 community-dwelling patients with COVID-19 followed in 21 tertiary centres in Italy, Iran, Spain, and the UK. Results: Overall mortality was 19.7%, with a significant effect of co-occurrence of dementia, hypertension, and PD duration. Conclusions: The frailty caused by advanced PD poses an increased risk of mortality during COVID-19.

Published
2020

39. LRRK2 G2019S mutation and Parkinson's disease: A clinical, neuropsychological and neuropsychiatric study in a large Italian sample

Author

Goldwurm, Stefano, Zini, Michela, Di Fonzo, Alessio, De Gaspari, Danilo, Siri, Chiara, Simons, Erik J., van Doeselaar, Marina, Tesei, Silvana, Antonini, Angelo, Canesi, Margherita, Zecchinelli, Anna, Mariani, Claudio, Meucci, Nicoletta, Sacilotto, Giorgio, Cilia, Roberto, Isaias, Ioannis U., Bonetti, A., Sironi, Francesca, Ricca, Sara, Oostra, Ben A., Bonifati, Vincenzo, and Pezzoli, Gianni

Published
2006
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41. Excessive Daytime Sleepiness in Multiple System Atrophy (SLEEMSA Study)

Author

Moreno-López, Claudia, Santamaría, Joan, Salamero, Manuel, Del Sorbo, Francesca, Albanese, Alberto, Pellecchia, Maria Teresa, Barone, Paolo, Overeem, Sebastiaan, Bloem, Bastiaan, Aarden, Willemijn, Canesi, Margherita, Antonini, Angelo, Duerr, Susanne, Wenning, Gregor K., Poewe, Werner, Rubino, Alfonso, Meco, Giuseppe, Schneider, Susanne A., Bhatia, Kailash P., Djaldetti, Ruth, Coelho, Miguel, Sampaio, Cristina, Cochen, Valerie, Hellriegel, Helge, Deuschl, Günther, Colosimo, Carlo, Marsili, Luca, Gasser, Thomas, and Tolosa, Eduardo

Published
2011
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43. Efficacy and tolerability of bevacizumab in patients with severe Covid -19

Author

Pang, Jiaojiao, primary, Xu, Feng, additional, Aondio, Gianmarco, additional, Li, Yu, additional, Fumagalli, Alberto, additional, Lu, Ming, additional, Valmadre, Giuseppe, additional, Wei, Jie, additional, Bian, Yuan, additional, Canesi, Margherita, additional, Damiani, Giovanni, additional, Zhang, Yuan, additional, Yu, Dexin, additional, Chen, Jun, additional, Ji, Xiang, additional, Sui, Wenhai, additional, Wang, Bailu, additional, Wu, Shuo, additional, Kovacs, Attila, additional, Revera, Miriam, additional, Wang, Hao, additional, Zhang, Ying, additional, Chen, Yuguo, additional, and Cao, Yihai, additional

Published
2020
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46. Imaging essential tremor

Author

Isaias, Ioannis U., Marotta, Giorgio, Hirano, Shigeki, Canesi, Margherita, Benti, Riccardo, Righini, Andrea, Tang, Chengke, Cilia, Roberto, Pezzoli, Gianni, Eidelberg, David, and Antonini, Angelo

Published
2010
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50. Adherence to antiparkinson medication in a multicenter European study

Author

Grosset, Donald, Antonini, Angelo, Canesi, Margherita, Pezzoli, Gianni, Lees, Andrew, Shaw, Karen, Cubo, Esther, Martinez-Martin, Pablo, Rascol, Olivier, Negre-Pages, Laurence, Senard, Ana, Schwarz, Johannes, Strecker, Karl, Reichmann, Heinz, Storch, Alexander, Löhle, Matthias, Stocchi, Fabrizio, and Grosset, Katherine

Published
2009
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