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1. Biosynthesis of 2-methylisoborneol in cyanobacteria

2. pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism.

3. Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.

4. Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.

5. Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes.

6. Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase.

7. Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.

8. Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases.

9. Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate.

10. Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases.

11. Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.

12. The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene.

13. Substitution of a Single Amino Acid Reverses the Regiospecificity of the Baeyer-Villiger Monooxygenase PntE in the Biosynthesis of the Antibiotic Pentalenolactone.

14. Structure and mechanism of assembly line polyketide synthases.

15. The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism.

16. Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase.

17. Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases.

18. Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.

19. Nature as organic chemist.

20. Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase.

21. Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.

22. Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.

23. A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases.

24. Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence.

25. Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host.

26. Terpene synthases are widely distributed in bacteria.

27. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange.

28. Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases.

29. Assembly line polyketide synthases: mechanistic insights and unsolved problems.

30. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.

31. Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase.

32. Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase.

33. In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase.

34. Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange.

35. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.

36. Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase.

37. Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

38. Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases.

39. Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase.

40. Product-mediated regulation of pentalenolactone biosynthesis in Streptomyces species by the MarR/SlyA family activators PenR and PntR.

41. Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket.

42. Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry.

43. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases.

44. Structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification.

45. Structure of 2-methylisoborneol synthase from Streptomyces coelicolor and implications for the cyclization of a noncanonical C-methylated monoterpenoid substrate.

46. Exploration and mining of the bacterial terpenome.

48. Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.

49. Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase.

50. Diversity and analysis of bacterial terpene synthases.

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