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17 results on '"Candela, Giuseppa"'

1. Changes in life expectancy for cancer patients over time since diagnosis

Author

Botta, Laura, Dal Maso, Luigino, Guzzinati, Stefano, Panato, Chiara, Gatta, Gemma, Trama, Annalisa, Rugge, Massimo, Tagliabue, Giovanna, Casella, Claudia, Caruso, Bianca, Michiara, Maria, Ferretti, Stefano, Sensi, Flavio, Tumino, Rosario, Toffolutti, Federica, Russo, Antonio Giampiero, Caiazzo, Anna Luisa, Mangone, Lucia, Mazzucco, Walter, Iacovacci, Silvia, Ricci, Paolo, Gola, Gemma, Candela, Giuseppa, Sardo, Antonella Sutera, De Angelis, Roberta, Buzzoni, Carlotta, and Capocaccia, Riccardo

Published
2019
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2. Causes of death in women with breast cancer: a risks and rates study on a population-based cohort.

Author

Contiero, Paolo, Boffi, Roberto, Borgini, Alessandro, Fabiano, Sabrina, Tittarelli, Andrea, Mian, Michael, Vittadello, Fabio, Epifani, Susi, Ardizzone, Antonino, Cirilli, Claudia, Boschetti, Lorenza, Marguati, Stefano, Cascone, Giuseppe, Tumino, Rosario, Fanetti, Anna Clara, Giumelli, Paola, Candela, Giuseppa, Scuderi, Tiziana, Castelli, Maurizio, and Bongiorno, Salvatore

Subjects
CANCER patients, CAUSES of death, DISEASE risk factors, CARDIOVASCULAR diseases, BREAST cancer, COHORT analysis
Abstract

Introduction: The increasing survival of patients with breast cancer has prompted the assessment of mortality due to all causes of death in these patients. We estimated the absolute risks of death from different causes, useful for health-care planning and clinical prediction, as well as cause-specific hazards, useful for hypothesis generation on etiology and risk factors. Materials and methods: Using data from population-based cancer registries we performed a retrospective study on a cohort of women diagnosed with primary breast cancer. We carried out a competing-cause analysis computing cumulative incidence functions (CIFs) and cause-specific hazards (CSHs) in the whole cohort, separately by age, stage and registry area. Results: The study cohort comprised 12,742 women followed up for six years. Breast cancer showed the highest CIF, 13.71%, and cardiovascular disease was the second leading cause of death with a CIF of 3.60%. The contribution of breast cancer deaths to the CIF for all causes varied widely by age class: 89.25% in women diagnosed at age <50 years, 72.94% in women diagnosed at age 50-69 and 48.25% in women diagnosed at age =70. Greater CIF variations were observed according to stage: the contribution of causes other than breast cancer to CIF for all causes was 73.4% in women with stage I disease, 42.9% in stage II-III and only 13.2% in stage IV. CSH computation revealed temporal variations: in women diagnosed at age =70 the CSH for breast cancer was equaled by that for cardiovascular disease and "other diseases" in the sixth year following diagnosis, and an early peak for breast cancer was identified in the first year following diagnosis. Among women aged 50-69 we identified an early peak for breast cancer followed by a further peak near the second year of follow-up. Comparison by geographic area highlighted conspicuous variations: the highest CIF for cardiovascular disease was more than 70% higher than the lowest, while for breast cancer the highest CIF doubled the lowest. Conclusion: The integrated interpretation of absolute risks and hazards suggests the need for multidisciplinary surveillance and prevention using communitybased, holistic and well-coordinated survivorship care models. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Characteristics of people living in Italy after a cancer diagnosis in 2010 and projections to 2020

Author

Guzzinati, Stefano, Virdone, Saverio, De Angelis, Roberta, Panato, Chiara, Buzzoni, Carlotta, Capocaccia, Riccardo, Francisci, Silvia, Gigli, Anna, Zorzi, Manuel, Tagliabue, Giovanna, Serraino, Diego, Falcini, Fabio, Casella, Claudia, Russo, Antonio Giampiero, Stracci, Fabrizio, Caruso, Bianca, Michiara, Maria, Caiazzo, Anna Luisa, Castaing, Marine, Ferretti, Stefano, Mangone, Lucia, Rudisi, Giuseppa, Sensi, Flavio, Mazzoleni, Guido, Pannozzo, Fabio, Tumino, Rosario, Fusco, Mario, Ricci, Paolo, Gola, Gemma, Giacomin, Adriano, Tisano, Francesco, Candela, Giuseppa, Fanetti, Anna Clara, Pala, Filomena, Sardo, Antonella Sutera, Rugge, Massimo, Botta, Laura, and Dal Maso, Luigino

Published
2018
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4. High fasting blood glucose and obesity significantly and independently increase risk of breast cancer death in hormone receptor-positive disease

Author

Minicozzi, Pamela, Berrino, Franco, Sebastiani, Federica, Falcini, Fabio, Vattiato, Rosa, Cioccoloni, Francesca, Calagreti, Gioia, Fusco, Mario, Vitale, Maria Francesca, Tumino, Rosario, Sigona, Aurora, Budroni, Mario, Cesaraccio, Rosaria, Candela, Giuseppa, Scuderi, Tiziana, Zarcone, Maurizio, Campisi, Ildegarda, and Sant, Milena

Published
2013
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5. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population-based cohort

Author

Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, Bernasconi, Alice, Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, and Bernasconi, Alice

Abstract

Background: Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow-up care. Methods: Population-based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15-39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs. Results: The cohort included 67,692 AYA cancer survivors. The excess risk of developing any SMN (SIR, 1.6; 95% confidence interval, 1.5-1.7) was 60%. The excess risk of SMNs was significantly high for survivors of lymphomas; cancers of the breast, thyroid, female genital tract, digestive organs, gonads, and urinary tract; and melanomas. The cumulative incidence of all SMNs in AYA cancer survivors within 25 years of their first cancer diagnosis was approximately 10%. Subsequent tumors contributing to approximately 60% of all SMNs were breast cancer, colorectal cancer, corpus uteri cancer, and ovarian cancer in females and colorectal cancer, bladder cancer, prostate cancer, lung cancer, and lymphomas in males. Conclusions: These results highlight the need to personalize follow-up strategies for AYA cancer survivors.

Published
2022

6. Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

Author

Ssenyonga, Naomi, primary, Stiller, Charles, additional, Nakata, Kayo, additional, Shalkow, Jaime, additional, Redmond, Shelagh, additional, Bulliard, Jean-Luc, additional, Girardi, Fabio, additional, Fowler, Christine, additional, Marcos-Gragera, Rafael, additional, Bonaventure, Audrey, additional, Saint-Jacques, Nathalie, additional, Minicozzi, Pamela, additional, De, Prithwish, additional, Rodríguez-Barranco, Miguel, additional, Larønningen, Siri, additional, Di Carlo, Veronica, additional, Mägi, Margit, additional, Valkov, Mikhail, additional, Seppä, Karri, additional, Wyn Huws, Dyfed, additional, Coleman, Michel P, additional, Allemani, Claudia, additional, Bouzbid, Sabiha, additional, Hamdi-Chérif, Mokhtar, additional, Kara, Lamia, additional, Meguenni, Kaouel, additional, Regagba, Derbali, additional, Bayo, Sine, additional, Cheick Bougadari, Traore, additional, Manraj, Shyam Shunker, additional, Bendahhou, Karima, additional, Ladipo, Akinade, additional, Ogunbiyi, Olufemi, additional, Somdyala, Nontuthuzelo, additional, Chaplin, María Agustina, additional, Moreno, Florencia, additional, Calabrano, Gladis, additional, Espinola, Silvia, additional, Carballo Quintero, Beatriz, additional, Fita, Rosalba, additional, Laspada, Walter, additional, Ibañez, Susana, additional, Lima, Carlos, additional, Mafra Da Costa, Allini, additional, De Souza, Paulo César, additional, Chaves, Juliana, additional, Laporte, Cyntia, additional, Curado, Maria Paula, additional, de Oliveira, Jose Carlos, additional, Veneziano, Claudia, additional, Veneziano, Donaldo, additional, Almeida, Ana Beatriz, additional, Latorre, Maria, additional, Azevedo e Silva, Gulnar, additional, Rebelo, Marise, additional, Santos, Marceli, additional, Galaz, Juan, additional, Aparicio Aravena, Mackarena, additional, Sanhueza Monsalve, Jocelyn, additional, Herrmann, Denise, additional, Vargas, Solange, additional, Herrera, Victor, additional, Uribe, Claudia, additional, Bravo, Luis Eduardo, additional, Garcia, Luz Stella, additional, Arias-Ortiz, Nelson, additional, Morantes, Daniela, additional, Jurado, Daniel, additional, Yépez Chamorro, María, additional, Delgado, Sandra, additional, Ramirez, Melissa, additional, Galán Alvarez, Yaima, additional, Torres, Priscila, additional, Martínez-Reyes, Fray, additional, Jaramillo, Leyda, additional, Quinto, Rina, additional, Castillo, Jhoanna, additional, Mendoza, Mariela, additional, Cueva, Patricia, additional, Yépez, José, additional, Bhakkan, Bernard, additional, Deloumeaux, Jacqueline, additional, Joachim, Clarisse, additional, Macni, Jonathan, additional, Carrillo, Rodolfo, additional, Shalkow Klincovstein, Jaime, additional, Rivera Gomez, Rebeca, additional, Perez, Patricia, additional, Poquioma, Ebert, additional, Tortolero-Luna, Guillermo, additional, Zavala, Diego, additional, Alonso, Rafael, additional, Barrios, Enrique, additional, Eckstrand, Angela, additional, Nikiforuk, Cindy, additional, Woods, Ryan, additional, Noonan, Gail, additional, Turner, Donna, additional, Kumar, Eshwar, additional, Zhang, Bin, additional, Dowden, Jeff, additional, Doyle, Gregory, additional, Walsh, Gordon, additional, Anam, Aniq, additional, McClure, Carol, additional, Vriends, Kim, additional, Bertrand, Christine, additional, Ramanakumar, Agnihotram, additional, Kozie, Serena, additional, Stuart-Panko, Heather, additional, Freeman, Tara, additional, George, Justin, additional, Avila, Rosa, additional, O'Brien, David, additional, Holt, Abby, additional, Almon, Lyn, additional, Ward, Kevin, additional, Kwong, Sandy, additional, Morris, Cyllene, additional, Rycroft, Randi, additional, Mueller, Lloyd, additional, Phillips, Cathryn, additional, Brown, Heather, additional, Cromartie, Betsy, additional, Ruterbusch, Julie, additional, Schwartz, Ann, additional, Levin, Gary, additional, Wohler, Brad, additional, Bayakly, Rana, additional, Gomez, Scarlett, additional, McKinley, Meg, additional, Cress, Rosemary, additional, Davis, Joni, additional, Hernandez, Brenda, additional, Johnson, Christopher, additional, Morawski, Bozena, additional, Ruppert, Laura, additional, Bentler, Suzanne, additional, Charlton, Mary, additional, Huang, Bin, additional, Tucker, Thomas, additional, Deapen, Dennis, additional, Liu, Lihua, additional, Hsieh, Mei-Chin, additional, Wu, Xiao-Cheng, additional, Schwenn, Molly, additional, Stern, Kimberly, additional, Gershman, Susan, additional, Knowlton, Richard, additional, Alverson, Georgetta, additional, Weaver, Tamara, additional, Desai, Jay, additional, Rogers, Deirdre, additional, Jackson-Thompson, Jeanette, additional, Lemons, Debbi, additional, Zimmerman, Heather, additional, Hood, Michelle, additional, Roberts-Johnson, Jenifer, additional, Hammond, Whitney, additional, Rees, Judith, additional, Pawlish, Karen, additional, Stroup, Antoinette, additional, Key, Charles, additional, Wiggins, Charles, additional, Kahn, Amy, additional, Schymura, Maria, additional, Radhakrishnan, Soundarya, additional, Rao, Chandrika, additional, Giljahn, Lynn, additional, Slocumb, Roberta, additional, Dabbs, Christy, additional, Espinoza, Raffaella, additional, Aird, Karen, additional, Beran, Todd, additional, Rubertone, Jim, additional, Slack, Stephen, additional, Oh, Junhie, additional, Janes, Tiffany, additional, Schwartz, Stephen, additional, Chiodini, Stephanie, additional, Hurley, Deborah, additional, Whiteside, Martin, additional, Rai, Saroj, additional, Williams, Melanie, additional, Herget, Kim, additional, Sweeney, Carol, additional, Johnson, Alison, additional, Keitheri Cheteri, Mahesh, additional, Migliore Santiago, Patti, additional, Blankenship, Steven, additional, Farley, Shawn, additional, Borchers, Robert, additional, Malicki, Robin, additional, Espinoza, Julia, additional, Grandpre, Joseph, additional, Edwards, Brenda, additional, Mariotto, Angela, additional, Weir, Hannah, additional, Wilson, Reda, additional, Wang, Ning, additional, Yang, Lei, additional, Chen, Jian-Shun, additional, He, Yu-Tong, additional, Song, Guo-Hui, additional, Gu, Xiao-Ping, additional, Mei, Dan, additional, Ge, Heng-Ming, additional, Wu, Tong-Hao, additional, Li, Yan-Yan, additional, Zhao, De-Li, additional, Jin, Feng, additional, Zhang, Jian-Hua, additional, Zhu, Feng-Dong, additional, Junhua, Qian, additional, Yang, Yan Lei, additional, Jiang, Chun-Xiao, additional, Biao, Wang, additional, Wang, Jian, additional, Li, Qi-Long, additional, Yi, He, additional, Zhou, Xin, additional, Dong, JianMei, additional, Li, WeiWei, additional, Fu, Fang-Xian, additional, Chen, Jian-Guo, additional, Zhu, Jian, additional, Li, Yan-Hua, additional, Lu, Yu-Qiang, additional, Fan, Min, additional, Huang, Su-Qin, additional, Guo, Guo-Ping, additional, Zhaolai, Hua, additional, Wei, Kuangrong, additional, Chen, Wan-Qing, additional, Wei, Wenqiang, additional, Zeng, Hongmei, additional, Demetriou, Anna, additional, Mang, Wai Kong, additional, Ngan, Kai Cheong, additional, Kataki, Amal, additional, Krishnatreya, Manigreeva, additional, Jayalekshmi, Padmavathi Amma, additional, Sebastian, Paul, additional, George, Preethi, additional, Mathew, Aleyamma, additional, Nandakumar, Ambakumar, additional, Malekzadeh, Reza, additional, Roshandel, Gholamreza, additional, Keinan-Boker, Lital, additional, Silverman, Barbara, additional, Ito, Hidemi, additional, Koyanagi, Yuriko, additional, Sato, Masako, additional, Tobori, Fumio, additional, Nakata, Ichiro, additional, Teramoto, Norihiro, additional, Hattori, Masakazu, additional, Kaizaki, Yasuharu, additional, Moki, Fumitaka, additional, Sugiyama, Hiromi, additional, Utada, Mai, additional, Nishimura, Makiko, additional, Yoshida, Keiichi, additional, Kurosawa, Katsuki, additional, Nemoto, Yuji, additional, Narimatsu, Hiroto, additional, Sakaguchi, Masahiko, additional, Kanemura, Seiki, additional, Naito, Michiko, additional, Narisawa, Rintaro, additional, Miyashiro, Isao, additional, Mori, Daisuke, additional, Yoshitake, Mayuko, additional, Oki, Izumi, additional, Fukushima, Norimasa, additional, Shibata, Akiko, additional, Iwasa, Keiichiro, additional, Ono, Chie, additional, Matsuda, Tomohiro, additional, Nimri, Omar, additional, Jung, Kyu-Won, additional, Won, Young-Joo, additional, Alawadhi, Eiman, additional, Elbasmi, Amani, additional, Ab Manan, Azizah, additional, Adam, Farzaana, additional, Nansalmaa, Erdenekhuu, additional, Tudev, Undarmaa, additional, Ochir, Chimedsuren, additional, Al Khater, Al Hareth, additional, El Mistiri, Mufid, additional, Lim, Gek Hsiang, additional, Teo, Yik Ying, additional, Chiang, Chun-Ju, additional, Lee, Wen-Chung, additional, Buasom, Rangsiya, additional, Sangrajrang, Suleeporn, additional, Suwanrungruang, Krittika, additional, Vatanasapt, Patravoot, additional, Daoprasert, Karnchana, additional, Pongnikorn, Donsuk, additional, Leklob, Atit, additional, Sangkitipaiboon, Somphob, additional, Geater, Sarayut, additional, Sriplung, Hutcha, additional, Ceylan, Okan, additional, Kög, Iskender, additional, Dirican, Oya, additional, Köse, Tülay, additional, Gurbuz, Tulın, additional, Karašahin, Füsun Emine, additional, Turhan, Duygu, additional, Aktaş, Umut, additional, Halat, Yakup, additional, Eser, Sultan, additional, Yakut, Cankut, additional, Altinisik, Merve, additional, Cavusoglu, Yasar, additional, Türkköylü, Ayşe, additional, Üçüncü, Nuršen, additional, Hackl, Monika, additional, Zborovskaya, Anna, additional, Aleinikova, Olga, additional, Henau, Kris, additional, Van Eycken, Liesbet, additional, Atanasov, Trayan, additional, Valerianova, Zdravka, additional, Šekerija, Mario, additional, Dušek, Ladislav, additional, Zvolský, Miroslav, additional, Steinrud Mørch, Lina, additional, Storm, Hans, additional, Wessel Skovlund, Charlotte, additional, Innos, Kaire, additional, Malila, Nea, additional, Jégu, Jérémie, additional, Velten, Michel, additional, Cornet, Edouard, additional, Troussard, Xavier, additional, Bouvier, Anne-Marie, additional, Guizard, Anne-Valérie, additional, Bouvier, Véronique, additional, Launoy, Guy, additional, Dabakuyo Yonli, Sandrine, additional, Poillot, Marie-Laure, additional, Maynadié, Marc, additional, Mounier, Morgane, additional, Vaconnet, Lina, additional, Woronoff, Anne-Sophie, additional, Daoulas, Mélanie, additional, Robaszkiewicz, Michel, additional, Clavel, Jacqueline, additional, Poulalhon, Claire, additional, Desandes, Emmanuel, additional, Lacour, Brigitte, additional, Baldi, Isabelle, additional, Pouchieu, Camille, additional, Amadeo, Brice, additional, Coureau, Gaëlle, additional, Monnereau, Alain, additional, Audoin, Magali, additional, D'Almeida, Tania, additional, Boyer, Séverine, additional, Hammas, Karima, additional, Trétarre, Brigitte, additional, Colonna, Marc, additional, Delafosse, Patricia, additional, Plouvier, Sandrine, additional, Cowppli-Bony, Anne, additional, Molinié, Florence, additional, Bara, Simona, additional, Ganry, Olivier, additional, Lapôtre-Ledoux, Bénédicte, additional, Daubisse-Marliac, Laetitia, additional, Bossard, Nadine, additional, Estève, Jacques, additional, Uhry, Zoé, additional, Stabenow, Roland, additional, Wilsdorf-Köhler, Heide, additional, Eberle, Andrea, additional, Luttmann, Sabine, additional, Löhden, Imma, additional, Nennecke, Alice, additional, Kieschke, Joachim, additional, Sirri, Eunice, additional, Justenhoven, Christina, additional, Zeissig, Sylke, additional, Holleczek, Bernd, additional, Eisemann, Nora, additional, Katalinic, Alexander, additional, Asquez, Rachelle, additional, Kumar, Vijay, additional, Petridou, Eleni, additional, Ólafsdóttir, Elínborg, additional, Tryggvadóttir, Laufey, additional, Murray, Deirdre, additional, Walsh, Paul, additional, Sundseth, Hildrun, additional, Mazzoleni, Guido, additional, Vittadello, Fabio, additional, Coviello, Enzo, additional, Cuccaro, Francesco, additional, Galasso, Rocco, additional, Sampietro, Giuseppe, additional, Magoni, Michele, additional, Ardizzone, Antonino, additional, D'Argenzio, Angelo, additional, Di Prima, Alessia Anna, additional, Ippolito, Antonella, additional, Lavecchia, Anna Maria, additional, Sutera Sardo, Antonella, additional, Gola, Gemma, additional, Ballotari, Paola, additional, Giacomazzi, Erica, additional, Ferretti, Stefano, additional, Dal Maso, Luigino, additional, Serraino, Diego, additional, Celesia, Maria Vittoria, additional, Filiberti, Rosa Angela, additional, Pannozzo, Fabio, additional, Melcarne, Anna, additional, Quarta, Fabrizio, additional, Andreano, Anita, additional, Russo, Antonio Giampiero, additional, Carrozzi, Giuliano, additional, Cirilli, Claudia, additional, Cavalieri d'Oro, Luca, additional, Rognoni, Magda, additional, Fusco, Mario, additional, Vitale, Maria Francesca, additional, Usala, Mario, additional, Cusimano, Rosanna, additional, Mazzucco, Walter, additional, Michiara, Maria, additional, Sgargi, Paolo, additional, Boschetti, Lorenza, additional, Chiaranda, Giorgio, additional, Seghini, Pietro, additional, Maule, Milena, additional, Merletti, Franco, additional, Spata, Eugenia, additional, Tumino, Rosario, additional, Mancuso, Pamela, additional, Vicentini, Massimo, additional, Cassetti, Tiziana, additional, Sassatelli, Romano, additional, Falcini, Fabio, additional, Giorgetti, Stefania, additional, Caiazzo, Anna Luisa, additional, Cavallo, Rossella, additional, Piras, Daniela, additional, Bella, Francesca, additional, Madeddu, Anselmo, additional, Fanetti, Anna Clara, additional, Maspero, Sergio, additional, Carone, Simona, additional, Mincuzzi, Antonia, additional, Candela, Giuseppa, additional, Scuderi, Tiziana, additional, Gentilini, Maria Adalgisa, additional, Rizzello, Roberto, additional, Rosso, Stefano, additional, Zanetti, Roberto, additional, Caldarella, Adele, additional, Intrieri, Teresa, additional, Bianconi, Fortunato, additional, Stracci, Fabrizio, additional, Contiero, Paolo, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Zorzi, Manuel, additional, Beggiato, Simonetta, additional, Brustolin, Angelita, additional, De Angelis, Roberta, additional, Gatta, Gemma, additional, Maurina, Anita, additional, Oniščuka, Marija, additional, Mousavi, Mohsen, additional, Lipunova, Nadezda, additional, Vincerzevskienė, Ieva, additional, Agius, Dominic, additional, Calleja, Neville, additional, Siesling, Sabine, additional, Visser, Otto, additional, Johannesen, Tom, additional, Trojanowski, Maciej, additional, Mierzwa, Tomasz, additional, Rachtan, Jadwiga, additional, Kępska, Kamila, additional, Kościańska, Beata, additional, Wójcik-Tomaszewska, Joanna, additional, Motnyk, Marcin, additional, Gos, Anna, additional, Bielska-Lasota, Magdalena, additional, Didkowska, Joanna, additional, Wojciechowska, Urszula, additional, Forjaz de Lacerda, Gonçalo, additional, Rego, Raul, additional, Carrito, Branca, additional, Pais, Ana, additional, Bento, Maria José, additional, Rodrigues, Jessica, additional, Lourenço, Antonio, additional, Mayer-da-Silva, Alexandra, additional, Blaga, Luminita, additional, Coza, Daniela, additional, Gusenkova, Lubov, additional, Lazarevich, Olga, additional, Prudnikova, Olga, additional, Vjushkov, Dmitri Mikhailovich, additional, Egorova, Alla, additional, Orlov, Andrey, additional, Pikalova, Lidiya, additional, Zhuikova, Lilia, additional, Adamcik, Juraj, additional, Safaei Diba, Chakameh, additional, Zadnik, Vesna, additional, Zagar, Tina, additional, De-La-Cruz, Marta, additional, Lopez-de-Munain, Arantza, additional, Aleman, Araceli, additional, Rojas, Dolores, additional, Chillarón, Rosario Jiménez, additional, Navarro, Ana Isabel Marcos, additional, Puigdemont, Montse, additional, Sánchez Perez, María-José, additional, Franch Sureda, Paula, additional, Ramos Montserrat, Maria, additional, Chirlaque López, Maria Dolores, additional, Sánchez Gil, Antonia, additional, Ardanaz, Eva, additional, Guevara, Marcela, additional, Cañete-Nieto, Adela, additional, Peris-Bonet, Rafael, additional, Carulla, Marià, additional, Galceran, Jaume, additional, Almela, Fernando, additional, Sabater, Consol, additional, Khan, Staffan, additional, Pettersson, David, additional, Dickman, Paul, additional, Staehelin, Katharina, additional, Struchen, Benjamin, additional, Herrmann, Christian, additional, Mousavi, Seyed Mohsen, additional, Egger Hayoz, Céline, additional, Bouchardy, Christine, additional, Schaffar, Robin, additional, Went, Philip, additional, Maspoli-Conconi, Manuela, additional, Kuehni, Claudia, additional, Bordoni, Andrea, additional, Ortelli, Laura, additional, Chiolero, Arnaud, additional, Konzelmann, Isabelle, additional, Rohrmann, Sabine, additional, Wanner, Miriam, additional, Broggio, John, additional, Rashbass, Jem, additional, Fitzpatrick, Deirdre, additional, Gavin, Anna, additional, Morrison, David, additional, Thomson, Catherine, additional, Greene, Giles, additional, Huws, Dyfed, additional, Coleman, Michel, additional, Matz, Melissa, additional, Sanz, Natalia, additional, Ssenyonga, Naomi, additional, Stephens, Richard, additional, Chalker, Elizabeth, additional, Smith, Mirka, additional, Gugusheff, Jessica, additional, You, Hui, additional, Qin Li, Shu, additional, Dugdale, Sarah, additional, Moore, Julie, additional, Philpot, Shoni, additional, Pfeiffer, Rhonda, additional, Thomas, Helen, additional, Silva Ragaini, Bruna, additional, Venn, Alison, additional, Evans, Sue, additional, Te Marvelde, Luc, additional, Savietto, Vedrana, additional, Trevithick, Richard, additional, Currow, David, additional, and Lewis, Chris, additional

Published
2022
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7. The relative contribution of the decreasing tumour thickness trend to the 2010s increase in net survival from cutaneous malignant melanoma in Italy: a population-based investigation

Author

Zamagni, Federica, Bucchi, Lauro, Mancini, Silvia, Crocetti, Emanuele, Maso, Luigino Dal, Ferretti, Stefano, Biggeri, Annibale, Villani, Simona, Baldacchini, Flavia, Giuliani, Orietta, Ravaioli, Alessandra, Vattiato, Rosa, Brustolin, Angelita, Candela, Giuseppa, Carone, Simona, Carrozzi, Giuliano, Cavallo, Rossella, Dinaro, Ylenia Maria, Ferrante, Margherita, Iacovacci, Silvia, Mazzoleni, Guido, Musolino, Antonino, Rizzello, Roverto Vito, Serraino, Diego, Stracci, Fabrizio, Tumino, Rosario, Masini, Carla, Ridolfi, Laura, Palmieri, Giuseppe, Stanganelli, Ignazio, and Falcini, Fabio

Subjects
Male, Skin Neoplasms, Italy, Humans, Female, Registries, Dermatology, Prognosis, Melanoma
Abstract

The long-term increase in survival from cutaneous malignant melanoma (CMM) is generally attributed to the decreasing trend in tumour thickness, the single most important prognostic factor.To determine the relative contribution of decreased tumour thickness to the favourable trend in survival from CMM in Italy.Eleven local cancer registries covering a population of 8 056 608 (13.4% of the Italian population in 2010) provided records for people with primary CMM registered between 2003 and 2017. Age-standardized 5-year net survival was calculated. Multivariate analysis of 5-year net survival was undertaken by calculating the relative excess risk (RER) of death. The relative contribution of the decrease in tumour thickness to the RER of death was evaluated using a forward stepwise flexible parametric survival model including the available prognostic factors.Over the study period, tumour thickness was inversely associated with 5-year net survival and multivariate RER in both sexes. The median thickness was 0.90 mm in 2003-2007, 0.85 mm in 2008-2012 and 0.75 mm in 2013-2017 among male patients, and 0.78 mm, 0.77 mm and 0.68 mm among female patients, respectively. The 5-year net survival was 86.8%, 89.2% and 93.2% in male patients, and 91.4%, 92.0% and 93.4% in female patients, respectively. In 2013-2017, male patients exhibited the same survival as female patients despite having thicker lesions. For them, the increasing survival trend was more pronounced with increasing thickness, and the inclusion of thickness in the forward stepwise model made the RER in 2013-2017 vs. 2003-2007 increase from 0.64 [95% confidence interval (CI) 0.51-0.80] to 0.70 (95% CI 0.57-0.86). This indicates that the thickness trend accounted for less than 20% of the survival increase. For female patients, the results were not significant but, with multiple imputation of missing thickness values, the RER rose from 0.74 (95% CI 0.58-0.93) to 0.82 (95% CI 0.66-1.02) in 2013-2017.For male patients in particular, decrease in tumour thickness accounted for a small part of the improvement in survival observed in 2013-2017. The introduction of targeted therapies and immune checkpoint inhibitors in 2013 is most likely to account for the remaining improvement.

Published
2022

8. Patient presentation, skin biopsy utilization and cutaneous malignant melanoma incidence and mortality in northern Italy: Trends and correlations.

Author

Bucchi, Lauro, Mancini, Silvia, Zamagni, Federica, Crocetti, Emanuele, Dal Maso, Luigino, Ferretti, Stefano, Baldacchini, Flavia, Giuliani, Orietta, Ravaioli, Alessandra, Vattiato, Rosa, Brustolin, Angelita, Candela, Giuseppa, Carone, Simona, Carrozzi, Giuliano, Cavallo, Rossella, Dinaro, Ylenia Maria, Ferrante, Margherita, Iacovacci, Silvia, Mazzoleni, Guido, and Musolino, Antonino

Subjects
SKIN biopsy, OFFICES, CUTANEOUS malignant melanoma, RANK correlation (Statistics), SKIN cancer, OUTPATIENT medical care, DEATH rate
Abstract

Background: The global increase in incidence of cutaneous malignant melanoma (CMM) occurring in the past decades has been partly attributed to increased diagnostic scrutiny of early lesions, with a potential phenomenon of overdiagnosis. The reported positive linear relation between skin biopsy rate and incidence of early CMM is compatible with this hypothesis. Objectives: We explored the ecological association between the trends in annual dermatologic office visit rates, skin biopsy rates, incidence rates of in situ and invasive CMM by tumour thickness category, and CMM mortality rates in the Emilia‐Romagna Region (northern Italy). Methods: Four cancer registries covering a population of 2,696,000 provided CMM incidence data for the years 2003–2017. Dermatologic office visit rates and skin biopsy rates were calculated using the Regional outpatient care database. All rates were age‐standardized. Trends were described with the estimated average annual per cent change (EAAPC). Correlations were tested with the Spearman correlation coefficient. Results: Incidence increased significantly. The increase was steeper for in situ CMM (EAAPC: men, 10.2; women, 6.9) followed by CMM <0.8 mm thick (9.1; 5.2), but the rates grew significantly for most subgroups of CMMs ≥0.8 mm thick. Mortality decreased significantly among women (−2.3) and non‐significantly among men. For dermatologic office visit rate and skin biopsy rate the EAAPC were, respectively, 1.7 and 1.8 for men and 1.2 and 0.9 for women. Annual dermatologic office visit rate correlated with skin biopsy rate in both sexes. However, the proportion of skin biopsies out of dermatologic office visits was constant across the years (range: men, 0.182–0.216; women, 0.157–0.191). Conclusions: In Italy, the increasing CMM incidence trend is, at least in part, genuine. Overdiagnosis—if any—is due to an increased patient presentation at dermatologic offices and not to a lower dermatologic threshold to perform biopsy. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population‐based cohort

Author

Trama, Annalisa, primary, Tittarelli, Andrea, additional, Barigelletti, Giulio, additional, Botta, Laura, additional, Gatta, Gemma, additional, Tagliabue, Giovanna, additional, Contiero, Paolo, additional, Guzzinati, Stefano, additional, Andreano, Anita, additional, Manneschi, Gianfranco, additional, Falcini, Fabio, additional, Castaing, Marine, additional, Filiberti, Rosa A., additional, Gasparotti, Cinzia, additional, Cirilli, Claudia, additional, Mazzucco, Walter, additional, Mangone, Lucia, additional, Iacovacci, Silvia, additional, Vitale, Maria F., additional, Stracci, Fabrizio, additional, Piffer, Silvano, additional, Tumino, Rosario, additional, Carone, Simona, additional, Sampietro, Giuseppe, additional, Melcarne, Anna, additional, Ballotari, Paola, additional, Boschetti, Lorenza, additional, Pisani, Salvatore, additional, Cavalieri D'Oro, Luca, additional, Cuccaro, Francesco, additional, D'Argenzio, Angelo, additional, D'Orsi, Giancarlo, additional, Fanetti, Anna C., additional, Ardizzone, Antonino, additional, Candela, Giuseppa, additional, Savoia, Fabio, additional, Pascucci, Cristiana, additional, Castelli, Maurizio, additional, Storchi, Cinzia, additional, and Bernasconi, Alice, additional

Published
2021
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11. The relative contribution of the decreasing trend in tumour thickness to the 2010s increase in net survival from cutaneous malignant melanoma in Italy: a population‐based investigation.

Author

Zamagni, Federica, Bucchi, Lauro, Mancini, Silvia, Crocetti, Emanuele, Dal Maso, Luigino, Ferretti, Stefano, Biggeri, Annibale, Villani, Simona, Baldacchini, Flavia, Giuliani, Orietta, Ravaioli, Alessandra, Vattiato, Rosa, Brustolin, Angelita, Candela, Giuseppa, Carone, Simona, Carrozzi, Giuliano, Cavallo, Rossella, Dinaro, Ylenia Maria, Ferrante, Margherita, and Iacovacci, Silvia

Subjects
MELANOMA, IMMUNE checkpoint inhibitors, MISSING data (Statistics), TUMORS, WOMEN patients
Abstract

Background: The long‐term increase in survival from cutaneous malignant melanoma (CMM) is generally attributed to the decreasing trend in tumour thickness, the single most important prognostic factor. Objectives: To determine the relative contribution of decreased tumour thickness to the favourable trend in survival from CMM in Italy. Methods: Eleven local cancer registries covering a population of 8 056 608 (13.4% of the Italian population in 2010) provided records for people with primary CMM registered between 2003 and 2017. Age‐standardized 5‐year net survival was calculated. Multivariate analysis of 5‐year net survival was undertaken by calculating the relative excess risk (RER) of death. The relative contribution of the decrease in tumour thickness to the RER of death was evaluated using a forward stepwise flexible parametric survival model including the available prognostic factors. Results : Over the study period, tumour thickness was inversely associated with 5‐year net survival and multivariate RER in both sexes. The median thickness was 0.90 mm in 2003–2007, 0.85 mm in 2008–2012 and 0.75 mm in 2013–2017 among male patients, and 0.78 mm, 0.77 mm and 0.68 mm among female patients, respectively. The 5‐year net survival was 86.8%, 89.2% and 93.2% in male patients, and 91.4%, 92.0% and 93.4% in female patients, respectively. In 2013–2017, male patients exhibited the same survival as female patients despite having thicker lesions. For them, the increasing survival trend was more pronounced with increasing thickness, and the inclusion of thickness in the forward stepwise model made the RER in 2013–2017 vs. 2003–2007 increase from 0.64 [95% confidence interval (CI) 0.51–0.80] to 0.70 (95% CI 0.57–0.86). This indicates that the thickness trend accounted for less than 20% of the survival increase. For female patients, the results were not significant but, with multiple imputation of missing thickness values, the RER rose from 0.74 (95% CI 0.58–0.93) to 0.82 (95% CI 0.66–1.02) in 2013–2017. Conclusions: For male patients in particular, decrease in tumour thickness accounted for a small part of the improvement in survival observed in 2013–2017. The introduction of targeted therapies and immune checkpoint inhibitors in 2013 is most likely to account for the remaining improvement. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Adolescent and Young Adult Cancer Survivors: Design and Characteristics of the First Nationwide Population-Based Cohort in Italy

Author

Bernasconi, Alice, primary, Barigelletti, Giulio, additional, Tittarelli, Andrea, additional, Botta, Laura, additional, Gatta, Gemma, additional, Tagliabue, Giovanna, additional, Contiero, Paolo, additional, Guzzinati, Stefano, additional, Andreano, Anita, additional, Manneschi, Gianfranco, additional, Falcini, Fabio, additional, Castaing, Marine, additional, Filiberti, Rosa Angela, additional, Gasparotti, Cinzia, additional, Cirilli, Claudia, additional, Mazzucco, Walter, additional, Mangone, Lucia, additional, Iacovacci, Silvia, additional, Vitale, Maria Francesca, additional, Stracci, Fabrizio, additional, Piffer, Silvano, additional, Tumino, Rosario, additional, Carone, Simona, additional, Sampietro, Giuseppe, additional, Melcarne, Anna, additional, Ballotari, Paola, additional, Boschetti, Lorenza, additional, Pisani, Salvatore, additional, Cavalieri D'Oro, Luca, additional, Cuccaro, Francesco, additional, D'Argenzio, Angelo, additional, D'Orsi, Giancarlo, additional, Fanetti, Anna Clara, additional, Ardizzone, Antonino, additional, Candela, Giuseppa, additional, Savoia, Fabio, additional, Pascucci, Cristiana, additional, Castelli, Maurizio, additional, Storchi, Cinzia, additional, and Trama, Annalisa, additional

Published
2020
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13. Changes in the Incidence of Thyroid Cancer Between 1991 and 2005 in Italy: A Geographical Analysis

Author

Lise, Mauro, primary, Franceschi, Silvia, additional, Buzzoni, Carlotta, additional, Zambon, Paola, additional, Falcini, Fabio, additional, Crocetti, Emanuele, additional, Serraino, Diego, additional, Iachetta, Francesco, additional, Zanetti, Roberto, additional, Vercelli, Marina, additional, Ferretti, Stefano, additional, La Rosa, Francesco, additional, Donato, Andrea, additional, De Lisi, Vincenzo, additional, Mangone, Lucia, additional, Busco, Susanna, additional, Tagliabue, Giovanna, additional, Budroni, Mario, additional, Bisanti, Luigi, additional, Fusco, Mario, additional, Limina, Rosa Maria, additional, Tumino, Rosario, additional, Piffer, Silvano, additional, Madeddu, Anselmo, additional, Bellù, Francesco, additional, Giacomin, Adriano, additional, Candela, Giuseppa, additional, Anulli, Monica Lucia, additional, and Dal Maso; for AIRTUM Working Group, Luigino, additional

Published
2012
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14. Adolescent and Young Adult Cancer Survivors: Design and Characteristics of the First Nationwide Population-Based Cohort in Italy

Author

Laura Botta, Giulio Barigelletti, A.C. Fanetti, Stefano Guzzinati, Anna Melcarne, Annalisa Trama, Simona Carone, Fabrizio Stracci, Giovanna Tagliabue, Rosa Filiberti, Giancarlo D'Orsi, Andrea Tittarelli, Paolo Contiero, Antonino Ardizzone, Angelo D'Argenzio, Cinzia Gasparotti, Cinzia Storchi, Gianfranco Manneschi, Fabio Falcini, Silvia Iacovacci, Anita Andreano, Marine Castaing, Silvano Piffer, Claudia Cirilli, Luca Cavalieri D'Oro, Paola Ballotari, Giuseppe Sampietro, Maurizio Castelli, Gemma Gatta, Giuseppa Candela, Francesco Cuccaro, Maria Francesca Vitale, Lucia Mangone, Fabio Savoia, Walter Mazzucco, Cristiana Pascucci, Lorenza Boschetti, Salvatore Pisani, Rosario Tumino, Alice Bernasconi, Bernasconi, Alice, Barigelletti, Giulio, Tittarelli, Andrea, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa Angela, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria Francesca, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, D'Oro, Luca Cavalieri, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna Clara, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, and Trama, Annalisa

Subjects
late outcomes, Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, late outcome, Population, Settore MED/42 - Igiene Generale E Applicata, Cohort Studies, Young Adult, Population based cohort, Cancer Survivors, Administrative database, Hospital discharge, Humans, Medicine, Young adult, education, education.field_of_study, business.industry, Absolute risk reduction, Cancer, survivors, cohort, medicine.disease, humanities, Italy, Oncology, population-based data, Pediatrics, Perinatology and Child Health, Cohort, Female, business
Abstract

Purpose: Adolescent and young adult (AYA, 15-39 years) cancer survivors (alive at least 5 years after cancer diagnosis) are less studied than younger and older cancer survivors and research on their late effects is limited. To facilitate research on long-term outcomes of AYA cancer survivors, we established, in Italy, a population-based AYA cancer survivors' cohort. This article describes the study design and main characteristics of this cohort. Methods: The cohort derives from population-based cancer registries (CRs). Each CR identified AYA cancer patients retrospectively. Treatment for first primary cancer and all health events from diagnosis to death can be traced through linkage with available health databases, such as hospital discharge records (HDRs), mortality files, and outpatient and pharmaceutical databases. Results: Thirty-four CRs participated to the cohort which overall includes 93,291 AYAs with cancer and 67,692 cancer survivors. First primary cancer distribution in AYA cancer survivors differs by sex and age groups because of the different cancer types diagnosed in AYAs. Almost 78% of AYA cancer survivors have HDRs and 14.8% also pharmaceutical and outpatient databases. Conclusion: This cohort will be used to study, for the first time in Italy, the pattern and excess risk of late effects in AYA cancer survivors. HDRs, outpatient and pharmaceutical databases will be used to define primary treatment to assess its impact on AYA cancer survivors' late effects. This cohort exploiting data sources already available at CRs, minimize the data collection effort and it will contribute to assess the feasibility of using administrative database to study cancer survivors' late effects.

Published
2020

15. [The extended contact tracing: the experience of Prevention Department of the Health Authority of Trapani Province (Sicily Region, Southern Italy)].

Author

Candela G and Di Gregorio F

Subjects
Humans, Italy epidemiology, Communication Barriers, Counseling, Disease Outbreaks prevention & control, Contact Tracing, COVID-19 prevention & control, COVID-19 epidemiology, SARS-CoV-2, Pandemics prevention & control, Transients and Migrants
Abstract

During the spread of SARS-CoV-2 virus, contact tracing proved to be a very effective public health tool. Within the local health authority of Trapani (Sicily Region, Southern Italy), contact tracing was managed by physician, prevention technicians, and administrative from the Health Prevention Department who were trained and updated during the evolution of the epidemic. Contact tracing has been extended to migrants who arrived in Trapani with the landings. Extended contact tracing had some critical factors related to language barriers, which reduced the effectiveness of the telephone contacts and psychological counseling during tracing, up to the loss of definition of high or low risk contacts among both migrants and rescuers. The team made up of workers from the Health Prevention Department, the Global Health Center, and Cultural Mediators was important in effectively managing the critical issues. The high number of cases occurred during the outbreak of COVID-19 in January 2022 has shown difficulties to support the contact tracing in this phase.

Published
2024
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16. The descriptive epidemiology of melanoma in Italy has changed - for the better.

Author

Bucchi L, Mancini S, Crocetti E, Dal Maso L, Baldacchini F, Vattiato R, Giuliani O, Ravaioli A, Zamagni F, Bella F, Bidoli E, Caldarella A, Candela G, Carone S, Carrozzi G, Cavallo R, Ferrante M, Ferretti S, Filiberti RA, Fusco M, Gatti L, Gili A, Iacovacci S, Magoni M, Mangone L, Mazzoleni G, Michiara M, Musolino A, Piffer S, Piras D, Rizzello RV, Rosso S, Rugge M, Scala U, Stracci F, Tagliabue G, Toffolutti F, Tumino R, Biggeri A, Masini C, Ridolfi L, Villani S, Palmieri G, Stanganelli I, and Falcini F

Subjects
Male, Humans, Female, Italy epidemiology, Biopsy, Immune Checkpoint Inhibitors, Molecular Targeted Therapy, Melanoma epidemiology
Abstract

A recent research project using data from a total of 40 cancer registries has provided new epidemiologic insights into the results of efforts for melanoma control in Italy between the 1990s and the last decade. In this article, the authors present a summary and a commentary of their findings. Incidence increased significantly throughout the study period in both sexes. However, the rates showed a stabilization or a decrease in men and women aged below 35 years. The risk of disease increased for successive cohorts born until 1973 (women) and 1975 (men) while subsequently tending to decline. The trend towards decreasing tumor thickness and increasing survival has continued, but a novel favorable prognostic factor has emerged since 2013 for patients - particularly for males - with thick melanoma, most likely represented by molecular targeted therapies and immune checkpoint inhibitors. Due to this, the survival gap between males and females has been filled out. In the meanwhile, and despite the incidence increase, dermatologists have not lowered their threshold to perform skin biopsy. Skin biopsy rate has increased because of the increasingly greater volume of dermatologic office visits, but the proportion of skin biopsies out of dermatologic office visits has remained constant. In summary, an important breakthrough in melanoma control in Italy has taken place. Effective interventions have been implemented across the full scope of care, which involve many large local populations - virtually the whole national population. The strategies adopted during the last three decades represent a valuable basis for further steps ahead in melanoma control in Italy.

Published
2023
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17. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population-based cohort.

Author

Trama A, Tittarelli A, Barigelletti G, Botta L, Gatta G, Tagliabue G, Contiero P, Guzzinati S, Andreano A, Manneschi G, Falcini F, Castaing M, Filiberti RA, Gasparotti C, Cirilli C, Mazzucco W, Mangone L, Iacovacci S, Vitale MF, Stracci F, Piffer S, Tumino R, Carone S, Sampietro G, Melcarne A, Ballotari P, Boschetti L, Pisani S, Cavalieri D'Oro L, Cuccaro F, D'Argenzio A, D'Orsi G, Fanetti AC, Ardizzone A, Candela G, Savoia F, Pascucci C, Castelli M, Storchi C, and Bernasconi A

Subjects
Adolescent, Adult, Female, Humans, Incidence, Male, Retrospective Studies, Risk Factors, Young Adult, Breast Neoplasms, Cancer Survivors, Neoplasms epidemiology, Neoplasms, Second Primary diagnosis, Neoplasms, Second Primary epidemiology
Abstract

Background: Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow-up care., Methods: Population-based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15-39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs., Results: The cohort included 67,692 AYA cancer survivors. The excess risk of developing any SMN (SIR, 1.6; 95% confidence interval, 1.5-1.7) was 60%. The excess risk of SMNs was significantly high for survivors of lymphomas; cancers of the breast, thyroid, female genital tract, digestive organs, gonads, and urinary tract; and melanomas. The cumulative incidence of all SMNs in AYA cancer survivors within 25 years of their first cancer diagnosis was approximately 10%. Subsequent tumors contributing to approximately 60% of all SMNs were breast cancer, colorectal cancer, corpus uteri cancer, and ovarian cancer in females and colorectal cancer, bladder cancer, prostate cancer, lung cancer, and lymphomas in males., Conclusions: These results highlight the need to personalize follow-up strategies for AYA cancer survivors., (© 2021 American Cancer Society.)

Published
2022
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