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Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder with significant metabolic implications, including an increased risk of cardiovascular diseases and diabetes. Kallistatin, a serine proteinase inhibitor with anti-inflammatory and antioxidative properties, has been identified as a potential biomarker for PCOS due to its role in modulating inflammation and oxidative stress. Methods: This prospective cohort study was conducted at a university hospital's gynecology clinic. It included 220 women diagnosed with PCOS and 220 healthy controls matched for age and body mass index. Kallistatin levels were quantitatively assessed using enzyme-linked immunosorbent assay (ELISA) techniques. Associations between kallistatin levels and clinical manifestations of PCOS, including hyperandrogenism and metabolic profiles, were examined. Results: Kallistatin levels were significantly lower in patients with PCOS (2.65 ± 1.84 ng/mL) compared to controls (6.12 ± 4.17 ng/mL; p < 0.001). A strong negative correlation existed between kallistatin levels and androgen concentrations (r = −0.782, p = 0.035). No significant associations were found between kallistatin levels and insulin resistance or lipid profiles. Conclusions: The findings indicate that reduced kallistatin levels are closely associated with PCOS and could serve as a promising biomarker for its diagnosis. The specific correlation with hyperandrogenism suggests that kallistatin could be particularly effective for identifying PCOS subtypes characterized by elevated androgen levels. This study supports the potential of kallistatin in improving diagnostic protocols for PCOS, facilitating earlier and more accurate detection, which is crucial for effective management and treatment. [ABSTRACT FROM AUTHOR]

Introduction: Endometriosis is a serious health problem among women of reproductive age, with pelvic pain and infertility. Given the limited success of current treatments, this study explores Neroli oil (N.O.) effects on inflammation, oxidation, angiogenesis, and tissue remodeling implicated in endometriosis. Materials and Methods: Albino Wistar female rats were used to simulate an endometriosis model. Groups were established for comparison: a control, an endometriosis model, a N.O.‐treated group, and a N.O.‐treated group postendometriosis induction. The study focused on Tumor necrosis factor‐alpha (TNF‐α), Interleukin 6, Interleukin 8, vascular endothelial growth factor (VEGF), myeloperoxidase, Matrix metalloproteinase‐1 (MMP‐1), nitric oxide, superoxide dismutase, catalase, and anti‐mullerian hormone values, as well as histopathological evaluations of endometriotic foci. Results: AMH values showed a significant increase in the endometriosis group treated with N.O. compared with the endometriosis group (p < 0,01).A statistically significant decrease was found in MMP‐1 level in the endometriosis group that underwent N.O. (p < 0.001). Increased CAT (p < 0.0001) and decrease in nitric oxide (p < 0.01) are found in N.O.‐treated endometriosis group. TNF‐α levels in the endometriosis group showed a statistically significant increase in the endometriosis group when compared with the control and sham group (p < 0.001, p < 0.01 respectively). In our study, a statistically significant increase was observed in VEGF levels (p < 0.001) in endometriosis group and significant decrease in the N.O. administered endometriosis model group. Groups treated with N.O. showed decreased inflammation and congestion scores. Histopathological assessments demonstrated reduced inflammation and tissue remodeling signs in endometriotic foci. Conclusion: This study highlights the potential of N.O. in the treatment of endometriosis, owing to its anti‐inflammatory, antioxidant, and antiangiogenic properties that can disrupt chronic processes. Our findings lend support to utilization of herbal remedies for the management of endometriosis, thereby emphasizing the necessity for additional comprehensive investigations in the future. [ABSTRACT FROM AUTHOR]

Aim: Patient satisfaction surveys stand as one of the most effective methods for assessing the quality of healthcare services, aimed at gathering feedback from patient opinions and recognizing the service provider's pivotal role. This study aims to measure the satisfaction of the patients receiving outpatient services in a tertiary center with the quality of these services and to prepare an infrastructure that can create policies that can respond to the needs and wishes of the people as a hospital. Material and Method: This study was conducted on 780 outpatients who applied obstetrics and gynecology services at Kafkas University Medical Faculty Training and Research Hospital, a tertiary public hospital, between November 2021 and February 2022." The questionnaire consisted of two parts, asking 15 questions about the service they received from the institution and six questions about their sociodemographic characteristics. Results: The highest Yes rate was 96.4% (752 people) as "The doctor who examined me was interested". The highest No rate was 31.0% (242 people) with the expression "I was informed about the waiting times in the hospital". While the lowest yes rate was 51.5% (402 people), the statement "The hospital was clean in general", the lowest no rate was again the statement "The doctor who examined me was interested". 87.1% of the participants (679 people) stated that the waiting time for registration was long, 52.7% said it was difficult to reach the hospital, and 88.8% (693 people) said they would recommend the hospital to their friends and family. Patients reported that they were generally satisfied with the services provided. Conclusion: Similar to every sector, the pursuit of quality in delivering healthcare services is a prevalent goal in today's healthcare sector. Patient satisfaction surveys are essential in terms of measuring these services. [ABSTRACT FROM AUTHOR]

Aim: A quality health service is not independent of patient satisfaction. Patient satisfaction research is one of the primary instruments for better quality service. With this study, we aimed to evaluate the satisfaction levels and expectations of the patients hospitalized in the Department of Gynecology and Obstetrics of the Kafkas University Training and Research Hospital to determine whether the satisfaction level differs according to socio-demographic characteristics and to restructure the light of the positive and negative data obtained. Material and Method: Between May 2021 and September 2022, 655 patients who received inpatient services at the Department of Gynecology and Obstetrics at Kafkas University Training and Research Hospital were surveyed. The questionnaire included a section about socio-demographic characteristics and 14 questions to determine their views on satisfaction. The questions were answered as 'yes', 'a little', and 'no'. Results: In our study, the highest level of satisfaction was for the nurses giving information about the treatment and care to the patient and the doctor's interest in the patient. According to the results of the multivariate linear regression analysis, it was determined that age, education status, and length of stay affected the satisfaction level independently of other variables (p<0.001). It was observed that working status did not affect satisfaction (p=0.434). Conclusion: Our study highlighted that hospital cleanliness significantly impacted the overall satisfaction levels, indicating a need for readjustments by hospital management. [ABSTRACT FROM AUTHOR]

OBJECTIVE: We aim to compare the effectiveness of oral contraceptives and dienogest, primarily by considering the quality of life scale. We also aim to compare the Cancer Antigen-125 and Anti-mullerian Hormone values. STUDY DESIGN: Gynecological examination findings evaluated based on ESHRE and ASRM Guideline criteria are compatible with endometriosis, or a previous surgery pathology result is consistent with endometriosis, and patients whose imaging report was compatible with endometriosis were selected. Among the patients who were recommended medical treatment, patients selected as Dionegest 2mg+Ethinylestradiol 0.03 mg (Dienelle) treatment were considered Group 1, and patients deemed suitable for treatment with treatment 2mg Dionegest (Visanne) were considered Group 2. Pre-treatment Cancer Antigen-125/Anti-mullerian Hormone values and SF-36 were recorded. RESULTS: There was no significant difference between drug groups in terms of education status, body mass index, family history, smoking, alcohol consumption, age, age at menarche, menstruation pattern, duration of menstruation, infertility, gestational status, job loss due to pain complaints, operation, and MRI findings (p>0.05). There was no significant difference between the drug groups regarding the quality of life before and after treatment (p>0.05). There was no significant difference between drug groups regarding endometrioma size, Cancer Antigen-125, and anti-mullerian hormone findings (p>0.05). CONCLUSION: Evaluating our data, the efficacy and success of the two treatment protocols were the same. It seems more logical to prefer cost-effective oral contraceptive treatments with a low side-effect profile than high-cost Dionegest. Following the guidelines accepted step therapy in treating mild or moderate endometriosis, cyclic oral contraceptives may be recommended as first-line therapy. [ABSTRACT FROM AUTHOR]