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Concepts and Methodology in Cancer Diagnostics: An Immunological, Biochemical and Molecular Approach provides an exclusive combination of all basics and recent techniques, methodology, and advancements in the field of cancer diagnostics. With a strong focus on the procedures and techniques involved in cancer diagnostics, content also gives insights into the molecular tests required for different tumors for the administration of targeted drugs and precision medicine. In 11 chapters. The book also introduces the methods and technologies based on DNA and RNA based biomarkers, biochemical and immunological markers, genetic signatures, epigenetic changes and exosomes in blood, and tissue and body fluids. Readers will find a compilation of imperative topics and lists of the necessary materials and reagents needed, step-by-step instructions, readily reproducible laboratory protocols, as well as tips on troubleshooting and known pitfalls. This book is a valuable resource for medical professionals and researchers who want to understand the concepts of validated protocols and methodologies in diagnosing cancer, its prognosis, and predictive value. - Discusses and provides solutions for quality control procedures in antibody tests in cancer diagnostics - Gives insights into the limitations and biasness of biomarker testing, specifically immunohistochemical and molecular markers - Provides procedures and addresses the challenges related to quality control, proficiency testing, accuracy, and precision of biomarker testing in cancer - Explores numerous methods used in basic and diagnostic laboratories to characterize cancer-related biomarkers, including cancer risk assessment, diagnosis, and determination of cancer progression

Methylene blue (MB) is a biocompatible and environmentally friendly material that has been widely used in clinical and biomedical research fields for over a century. In addition, it also has wide applications in other fields, such as dyeing and finishing industry, aquaculture industry, photocatalysis and food industry.This landmark publication is unique as it covers MB-mediated in vivo fluorescence, photoacoustic imaging and light-induced cancer therapy. The optical properties and photothermal effect of MB are also systematically described.

Current Cancer Biomarkers is a comprehensive review on the status of biological markers for various types of cancer. It aims to update readers on current developments on the subject. The contents are divided into 5 sections covering a wide range of biomarkers and their diagnostic applications. The range of tumour biomarkers referenced here gives insights into molecular mechanisms behind cancer, including initiation, development, progression, prognosis, response to the therapeutic modalities, recurrence, and point-of-care application to detect cancer. Key features- Introduction of the basic features of cancer markers- Comprehensive and updated coverage of potential and effective biomarkers including genomic, epigenomic, transcriptomic, proteomic, cellular and morphologic factors- Information on biomarkers in many types of cancers including breast cancer, colorectal cancer, skin cancer, leukemia, liver cancer and prostate cancer- Applications of biomarkers in cancer diagnosis- Structured contents with easy-to-understand sections and headings- References for advanced readers The updated information about different aspects of cancer markers in the experimental and clinical setting will enrich the reader's understanding of the disease. The information serves as a resource to help in better management of cancer patients and understanding cancer biology when planning medical research projects. The book is intended as a reference for a diverse audience: biomedical science students, medical students, academics, researchers, clinicians and multidisciplinary teams involved in cancer management and research.

This book describes intraoperative flow cytometry in solid tumours. Intraoperative flow cytometry is an innovative technique for assessing tumour margins and grade of malignancy intraoperatively. The authors have been working on this procedure for more than 14 years and have introduced it in the surgery of intracranial tumours, breast cancer, liver cancer and head and neck neoplasms, as described in the book. A detailed description of the main pathological findings will be followed by an explanation of the intraoperative flow cytometry's role. In each chapter, information will be provided to stimulate further research on this topic. The book will also include new topics that have not been published till now. The book is aimed at neurosurgeons, general surgeons, ENT specialists, breast surgeons, radiologists, pathologists, oncologists, biologists, biochemists and scientists working with on flow cytometry.

HOLLAND-FREI CANCER MEDICINE The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition of Holland-Frei Cancer Medicine, a team of distinguished researchers and practitioners delivers a comprehensive and up-to-date discussion of cancer science and clinical oncology practice. The book contains timely and indispensable information on epidemiology, etiology, cancer biology, immunology, prevention, screening, clinical presentation, pathology, imaging, and therapy. Grounded in a fundamental understanding of cancer biology, Holland-Frei Cancer Medicine combines scientific principles with clinical practice. It contains hundreds of full-color illustrations and photographs, tables, graphs, and algorithms that complement and enhance the complex topics discussed within the book. This book is an invaluable clinical tool that provides readers with overview boxes, additional references, and other pedagogic features designed to make the content easy to access and comprehend. Readers will also find: A translational and integrated approach throughout the book that combines cancer biology with cancer management A strong emphasis on multidisciplinary, research-driven patient care that improves outcomes and allows for the optimal use of all clinically appropriate therapies Discussions of the most current personalized cancer care, including molecular diagnostics and therapeutics Perfect for medical oncologists, radiation oncologists, and internists, Holland-Frei Cancer Medicine, Tenth Edition will also earn a place in the libraries of allied health professionals involved in the treatment of cancer patients. This book is published in collaboration with the American Association for Cancer Research: https://www.aacr.org/

An essential resource to solve challenging cases and sign out with confidence! An all-new volume in the popular Foundations in Diagnostic Pathology series, Differential Diagnoses in Surgical Pathology: Tumors and Their Mimickers is a crucial foundation text for residents and pathologists. Packed with information that helps you quickly differentiate entities that have similar, overlapping histopathologic features, it guides you through the decision-making process, providing a road map to the main differential diagnostic considerations that must be addressed when formulating a diagnosis. Practical and affordable, this resource is ideal for study and review, as well as for everyday surgical pathology practice.Key features of this practical text include: - Concise summaries of clinical and pathologic findings that guide you through the decision-making process, with coverage of most common and uncommon differential diagnoses in surgical pathology. - Numerous high-quality illustrations of similar-looking but distinct entities for easy side-by-side comparison. - Illustrations for each entity accompanied by a clear, concise histopathologic descriptions that highlight how they are distinguished from one another. - A consistent, user-friendly format and at-a-glance boxes and tables throughout the text, as well as selected references for further study. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

By turns somber and funny but above all provocative, Elizabeth Benedict's Rewriting Illness: A View of My Own is a most unconventional memoir. With wisdom, self-effacing wit, and the story-telling skills of a seasoned novelist, she brings to life her cancer diagnosis and committed hypochondria. As she discovers multiplying lumps in her armpit, she describes her initial terror, interspersed with moments of self-mocking levity as she indulges in “natural remedies,” among them chanting Tibetan mantras, drinking shots of wheat grass, and finding medicinal properties in chocolate babka. She tracks the progression of her illness from muddled diagnosis to debilitating treatment as she gathers sustenance from her family and an assortment of urbane, ironic friends, including her fearless “cancer guru.” In brief, explosive chapters with startling titles – “Was it the Krazy Glue?” and “Not Everything Scares the Shit out of Me” – Benedict investigates existential questions: Is there a cancer personality? Can trauma be passed on generationally? Can cancer be stripped of its warlike metaphors? How do doctors'own fears influence their comments to patients? Is there a gendered response to illness? Why isn't illness one of literature's great subjects? And delving into her own history, she wonders if having had children would have changed her life as a writer and hypochondriac. Post diagnosis, Benedict asks, “Which fear is worse: the fear of knowing or the reality of knowing? (164)”Throughout, Benedict's humor, wisdom, and warmth jacket her fears, which are personal, political, and ultimately global, when the world is pitched into a pandemic. Amid weighty concerns and her all-consuming obsession with illness, her story is filled with suspense, secrets, and even the unexpected solace of silence.

Electromagnetic Waves-Based Cancer Diagnosis and Therapy: Principles and Applications of Nanomaterials is a reference solution for radiation-based methods in cancer therapy that benefit from nanosystems. The book gives foundational knowledge and the latest techniques across the electromagnetic wave spectrum. It assesses the advantages and limitations of nanosystems in therapy, providing researchers and specialists with the insight to leverage novel nanostructures for therapy and to improve the efficacy of existing methods. It presents a comprehensive reference on the use of nanosystems in radiation-based cancer therapy. What makes this book unique is its coverage of the electromagnetic wave spectrum. Six chapters cover radio-wave-involved cancer therapy and imaging; cancer therapy by microwaves hypothermia; infra-red waves in cancer theranostics; the use of visible light in diagnosis; X-ray based treatments; and gamma ray-involved therapy and imaging. This book offers researchers and specialists a comprehensive overview of radiation-based methods using nanosystems. It will be of great use to researchers and specialists in cancer diagnosis who want to take advantage of novel nanostructures and to improve the performance of conventional methods in radiation-based cancer diagnosis and therapy. - Provides a comprehensive reference of radiation-based methods in cancer therapy benefiting from nanosystems - Presents advantages and limitations in the use of nanosystems for radiation-based methods in cancer therapy - Helps researchers and specialists leverage the potential of novel nanostructures for therapy - Offers ways to improve the performance of conventical methods using nanosystems, making this a one-stop solution to the use of nanosystems in radiation-based cancer therapy

The applications of nanoparticulate drug delivery have gained significant attention in cancer diagnosis and treatment. Owing to their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine spans multitudes of drug-delivery systems that include high tumor-targeting ability, sensitivity toward tumor microenvironments, and improved efficacy. Various nanocarriers have been developed and approved for anti-tumor drug targeting. These nanocarriers, such as liposomes, micelles, nanotubes, dendrimers, and peptides, offer several advantages including high selectivity, multifunctionality, specificity, biocompatibility, and precise control of drug release. This book provides complete information about each aspect of nanomaterials and nanotherapeutics, including synthesis, analysis, disease diagnosis, mechanistic insight, targeted drug delivery, and clinical implications in a concise and informative way. It presents simple and reader-friendly representations of the mechanisms of action of nanomaterials on cellular targets and highlights the challenges in targeted drug delivery with ongoing chemotherapeutic drugs.

This book provides information about different types and stages of cancer and their subtypes with their respective molecular mechanisms, etiology, histopathology, and cellular origins. This book also provides detailed information about cancer incidence, mortality, and different types of technologies both bio and nano employed in cancer diagnosis and screening, and their applications in cancer therapies. This book informs readers about molecular mechanisms of cancer, diagnosis, and therapies along with different computational techniques used on a single platform.The chapters include a broad and integrated perspective on cancer-related topics. This book covers both conventional and emerging techniques employed in cancer screening and diagnosis, including imaging, biomarker, and electrochemical nanosensor-based approaches with detailed information on sensor development. Similarly, this book also covers the mechanisms of different conventional and emerging herbal and nano therapies used in cancer treatment. The authors discuss applications of different computational and mathematical tools, such as machine-learning methods, that can be employed in cancer diagnosis and therapy at the level of personalized medicine.Features: Offers an integrated approach to provide information about all aspects of cancer biology, diagnosis, and therapy Focuses on both conventional and emerging tools/techniques applicable in cancer screening and diagnosis Covers the mechanisms of conventional and emerging anticancer drugs and therapies Provides insights about a personalized medicine-based approach in cancer diagnosis and therapy This book is essential for university students, course lecturers, researchers, and industrialists working in the fields of cancer biology, medicine, and pharmacology.

Fundamentals of Cancer Detection, Treatment, and Prevention The professional guide to cancer diagnosis and therapy for researchers and clinicians In Fundamentals of Cancer Detection, Treatment, and Prevention, distinguished researcher Surya K. De delivers a concise and authoritative guide to cancer treatment, diagnosis, and prevention. The book offers a comprehensive overview of cancer in humans, from its causes, symptoms, and diagnosis to the variety of treatment options available today. Intuitively organized by cancer type, this guide provides concise information on risk factors, diagnosis, and treatment options for all commonly encountered tumors, including surgery, radiation therapy, chemotherapy, and immunotherapy. All US FDA-approved drugs—like small molecules, peptides, monoclonal antibodies, whole antibodies, gene therapy, antibody-drug conjugates, and cell therapies—are considered, and information about their generic and brand names, clinical uses, and mechanisms of action is presented. Readers will also find: A thorough overview of human cancers, including cancer risk factors and possible preventions Comprehensive explorations of bladder, blood, brain, and spinal cord cancers Practical discussions of breast, colorectal, cervical, kidney, and liver cancer In-depth examinations of lung, skin, ovarian, vaginal, vulvar, pancreatic, and prostate cancers, as well as mesothelioma Perfect for pharmaceutical chemists, oncologists, pharmacologists, and medicinal chemists, Fundamentals of Cancer Detection, Treatment, and Prevention is an indispensable guide for professional researchers, whether they are working in the clinic or the pharmaceutical industry.

Cancer screening is a prominent strategy in cancer control in the United States, yet the ability to correctly interpret cancer screening data eludes many researchers, clinicians, and policy makers. This open access primer rectifies that situation by teaching readers, in simple language and with straightforward examples, why and how the population-level cancer burden changes when screening is implemented, and how we assess whether that change is of benefit. This book provides an in-depth look at the many aspects of cancer screening and its assessment, including screening phenomena, performance measures, population-level outcomes, research designs, and other important and timely topics. Concise, accessible, and focused, Assessment of Cancer Screening: A Primer is best suited to those with education or experience in clinical research or public health in the United States - no previous knowledge of cancer screening assessment is necessary. This is the first text dedicated to cancer screening theory and methodology to be published in 20 years.

Circulating cell-free DNA is poised to transform cancer diagnosis and care; however, it carries technical challenges such as low abundance, fragmentation and sensitivity to biospecimen handling. Development of clinically useful assays hinges on understanding the unique technical aspects of working with cell-free DNA as a substrate. This book provides an in-depth summary of the technical issues impacting cell-free DNA purification from blood plasma and analysis in a cancer context, including design of PCR assays, sequencing library preparation and methylation analysis. Emerging fields such as extracellular vesicles and blood nucleases are also covered, as well as basic biology and considerations pertinent to biobanking.

The book is an update on contentious or unsettled issues concerning invasive diagnostic and therapeutic challenges in cancer and related disorders, focusing on the surgical approach. Topics include recommendations for the best practice in using the surgery safety checklist, surgical strategies in a variety of thoracic cancers, renal cell carcinoma, tumors of parathyroid glands, mesothelioma, and bariatric surgeries. The focus is on the diagnostic and therapeutic challenges of aggressive cancerous entities, choosing the most beneficial modes for optimal outcomes and patient survival. Chapters also address radioimaging and therapy outcomes in different intracranial lesions leading to severe neurological disabilities. The areas of medical practice addressed are still veiled in uncertainty, yet-unresolved pathogenetic background, and have a substantial component of empirical rather than evidence-based clinical approach. Pursuing and sharing new ideas and innovations is essential for improving the management and outcome. The book endeavors to disseminate and deliberate on the latest medical knowledge, studies, and advancements in surgical and diagnostic dealing with cancer. The book is addressed to physicians and surgeons, and all allied health care professionals engaged in patient care and therapy.

This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.

Cancer is the second leading cause of death among adults in the United States after heart disease. However, improvements in cancer treatment and earlier detection are leading to growing numbers of cancer survivors. As the number of cancer survivors grows, there is increased interest in how cancer and its treatments may affect a person's ability to work, whether the person has maintained employment throughout the treatment or is returning to work at a previous, current, or new place of employment. Cancer-related impairments and resulting functional limitations may or may not lead to disability as defined by the U.S. Social Security Administration (SSA), however, adults surviving cancer who are unable to work because of cancer-related impairments and functional limitations may apply for disability benefits from SSA. At the request of SSA, Diagnosing and Treating Adult Cancers and Associated Impairments provides background information on breast cancer, lung cancer, and selected other cancers to assist SSA in its review of the listing of impairments for disability assessments. This report addresses several specific topics, including determining the latest standards of care as well as new technologies for understanding disease processes, treatment modalities, and the effect of cancer on a person's health and functioning, in order to inform SSA's evaluation of disability claims for adults with cancer.

Cancer continues to be a growing problem as it is the foremost cause of death worldwide, killing millions of people each year. The number of people battling cancer continues to increase, owing to different reasons, such as lifestyle choices. Clinically, determining the cause of cancer is very challenging and often inaccurate. Incorporating efficient and accurate algorithms to detect cancer cases is becoming increasingly beneficial for scientists in computer science and healthcare, as well as a long-term benefit for doctors, patients, clinic practitioners, and more. Specifically, an automation of computation in machine learning could be a solution in the next generation of big data science technology. Machine Learning in Cancer Research With Applications in Colon Cancer and Big Data Analysis presents algorithms that have been developed to evaluate big data approaches and cancer research. The chapters include artificial intelligence and machine learning approaches, as well as case studies to solve the predictive issues in colon cancer research. This book includes concepts and techniques used to run tasks in an automated manner with the intent to improve better accuracy in comparison with previous studies and methods. This book also covers the processes of research design, development, and outcome analytics in this field. Doctors, IT consultants, IT specialists, medical software professionals, data scientists, researchers, computer scientists, healthcare practitioners, academicians, and students can benefit from this critical resource.

This useful reference provides solid knowledge of the risks and benefits associated with the cancer screening process, assesses abnormal results and therapeutic outcomes, and facilitates the communication of these issues to patients. Describes screening tests from individual, health care, ethical, legal, and regulatory perpectives! Gatherin

This text provides the necessary tools and up-to-date information on the morphological approach and most current use of ancillary techniques in the diagnosis and treatment of malignant tumors. The work is divided by sub specialty areas so that the reader can easily obtain the information desired. Features of histopathological lesions are presented in each area, as well as an up-to-date use of the different immunohistochemical stains and molecular biology features, when applicable, which are commonly used to determine treatment modalities. All sub specialty sections are written by sub specialty pathologists with experience in tumor pathology and who work in a cancer center. Each chapter is richly illustrated and properly referenced. Oncological Surgical Pathology will be of use not only for pathologists (including pathology residents and fellows), but also for oncological surgeons, oncologists and interventional radiologists.

Diagnosis can be a deep investigative process, complex by nature. The diagnostic processes have become much more multidisciplinary, demanding the use of an eclectic set of technological methodologies and tools, especially from the Fourth Revolution. Biosensors, Artificial Intelligence, Internet of Things and 3D Printing have become common terms in health research. Cancer in all its forms has become one of the biggest public health issues of the twentieth century. Among all types of cancer, breast cancer is the most dangerous for older and middle-aged women; it is also the most common form of cancer among the female population. Breast cancer is among the five most common cancers worldwide. This disease has been proliferating in developed, under-developed and developing countries. Its incidence rate is increasing with the average life expectancy of the population and with the adoption of new forms of consumption. There are some preventive strategies for breast cancer, such as stimulating visual inspection and touching of the breasts. However, they are not efficient enough to impact breast cancer mortality rate because the disease is still being diagnosed late in many cases. Therefore, a deeper understanding of the disease is necessary, including its risk factors and strategies for early identification and efficient treatment. The existence of these tools in public healthcare systems is important because they may contribute to increasing the chances of cure and the treatment options, decreasing mortality rates. Herein this collection book, we present to readers a set of works from the state-of-the-art dealing with cancer diagnosis using biosensors, artificial intelligence and other approaches. We hope this collection could present some of the state of the art of innovative techniques based on the Fourth Industrial Revolution to support early and accurate diagnosis of cancer, especially breast cancer.

This comprehensive reference provides an overview of the general principles of cancer staging, as well as specific discussions of each tumour type across the body, including lymphoma and haematological malignancies. For each tumour, the pattern of disease involvement and disease spread are emphasized, the state-of-the-art imaging features surveyed, and the latest tumour staging and methods to assess treatment response are addressed. Separate sections discuss metastatic disease and the effects of treatment on normal and diseased tissues. The final section of the book highlights emerging functional and molecular imaging techniques to evaluate the different biological hallmarks of cancer.

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion. - Provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment and prevention of cancer - Discusses how the properties of specific biomaterials make them important in cancer treatment - Covers synthetic vaccines, proteins and polymers for cancer therapeutics