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Oxford BioMedica, which specialises in cancer treatments based on gene therapy, has acquired Oxxon Therapeutics, the therapeutic vaccine company, for Pounds 16m in an all-share deal that expands its immunotherapy [...]

Jul 27, 2008 (WENN via COMTEX) -- The man who created the vaccine protecting against cervical cancer is now saying that genetic technology will govern the new developments in cancer [...]

Dec. 10--Possibly as many as a fifth of all forms of cancer are caused by chronic infections, and if vaccine and drug efforts were substantially boosted worldwide, thousands of cancers [...]

Researchers report that by altering genes in tumor cells they have been able to turn on killer immune cells that attack deadly brain cancers. In a study being published Friday […]

M2 EUROPHARMA-(C)1999-2010 M2 COMMUNICATIONS 11 January 2010 - US-based biopharmaceutical company Vical Incorporated (NASDAQ:VICL) announced today that the US Department of Agriculture (USDA) has granted the company's licensee Merial Limited, [...]

Researchers detail in 'Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen,' new data in cancer gene therapy. "B-cell-based cellular vaccines represent a [...]

Researchers detail in 'Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen,' new data in cancer gene therapy. According to a study from [...]

"Through their ability to induce cytotoxic T-lymphocytes and inhibit Foxp3(+) T-regulatory cells, Escherichia coli expressing listeriolysin-O (LLO) and a model tumor antigen have been shown to exert strong antitumor activity. [...]

"The transformation of a healthy cell into a malignant neoplasm involves numerous genetic mutations and aberrations in gene expression. As few of these changes are shared between individuals or types [...]

According to a study from the United States, 'Tumor cells harbor unique genetic mutations, which lead to the generation of immunologically foreign antigenic peptide repertoire with the potential to induce [...]

"Papillomavirus-like particles (VLPs) based on L1 capsid protein represent a promising prophylactic vaccine against human papillomavirus (HPV) infections. However, cell-mediated immune responses against this antigen are believed to be of [...]

"The highly aggressive cancer syndrome of female mice carrying a p53 knockout allele and a rat HER-2/neu (Neu) transgene (BALB-p53Neu) can be prevented by a cell vaccine presenting three components: [...]

Investigators publish new data in the report 'Immune response to vaccination with DNA-Hsp65 in a phase I clinical trial with head and neck cancer patients.' 'DNA-hsp65, a DNA vaccine encoding [...]

According to recent research published in the journal Human Gene Therapy, "Aberrant Her2/neu expression is associated with the development of epithelial-derived human carcinomas and for this reason it is considered [...]

According to recent research published in the Journal of Cancer Research and Clinical Oncology, "Genetic vaccination by expression plasmids that encode mutant p53 was conducted to characterize exogenously induced anti-tumoral [...]

Research findings, 'An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models,' are discussed in a new report. According to a study from Pomezia, [...]

"Dendritic cell (DC) targeting in vivo has recently been shown to confer strong and protective cytotoxic T lymphocyte (CTL) based immunity in tumor murine models. Our group has recently demonstrated [...]

Fresh data on cancer gene therapy are presented in the report 'Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy.' According to recent research from Strasbourg, France, 'The delivery [...]

According to recent research published in the Journal of Immunology, "With a 5-year survival rate of < 5%, pancreatic cancer is one of the most rapidly fatal malignancies. Current protocols [...]

According to recent research published in the journal Cancer Research, "Genetic regulation of immune reactivity to Her-2 vaccination and the consequent antitumor effect was tested in human Her-2 transgertic (Tg) [...]

According to recent research from the United States, "Locally produced transforming growth factor-beta (TGF-beta) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. This article explores the potential for increased [...]

"Tumors may present antigens to T cells but lack costimulatory signals which are necessary to initialize an effective immunologic response. This study aimed to develop a tumor cell-based cancer vaccine [...]

' IL-21 is the most recently identified member of the IL-2 cytokine family. Here we studied the therapeutic efficacy of IL-21-gene-modified cells (Neuro2a/IL-21) in a syngeneic metastatic neuroblastoma (NB) model,' [...]

A new study, 'Targeting metastatic cancer from the inside: a new generation of targeted gene delivery vectors enables personalized cancer vaccination in situ,' is now available. According to a study [...]

Epeius Biotechnologies Corporation announced the publication of another landmark paper describing recent technological advances in medical gene delivery. The latest scientific paper, entitled "Targeting metastatic cancer from the inside: A [...]

A report, 'Current status of experimental therapeutics for prostate cancer,' is newly published data in Cancer Letters. "Hormone refractory prostate cancer (HRPC) is the progression of disease in the presence [...]

Research findings, 'Measles virus as an oncolytic vector platform,' are discussed in a new report. According to a study from the United States, "Viral vector systems are widely being used [...]

A breast cancer vaccine currently being tested in a Phase II trial is safe and well tolerated in patients, according to a paper to be published in an upcoming issue [...]

According to a study from Toronto, Canada, 'Gene therapy strategies may accelerate the development of prophylactic immunotherapy against cancer. We synthesized a lentiviral (LV) vector encoding a kinase-deficient form of [...]

Fresh data on vaccines are presented in the report 'Enhanced protein expression by internal ribosomal entry site-driven mRNA translation as a novel approach for in vitro loading of dendritic cells [...]

"Despite recent advances in cancer immunotherapy, cellular mechanisms controlling expression of tumor-associated antigens are poorly understood. Mutations in cancer cells, such as loss of PTEN, may increase expression of: tumor-associated [...]

"The ideal immunological target for cancer vaccine development would meet the criteria of tumor specificity, immuno-genicity and vital dependency of the tumor on the functional activities of the antigenic target [...]

A tattoo can be more than just a fashion statement u it has potential medical value, according to an article published in the online open access journal, Genetic Vaccines and [...]

Investigators publish new data in the report 'Enhanced immunity to intracerebral breast cancer in mice immunized with a cDNA-based vaccine enriched for immunotherapeutic cells.' According to recent research from the [...]

Data detailed in 'The TAG family of cancer/testis antigens is widely expressed in a variety of malignancies and gives rise to HLA-A2-restricted epitopes' have been presented (see also Cancer Vaccines). [...]

Oncology Metrics, a business that develops products and services to help accelerate advancements in the treatment of cancer, and Cureline Inc., a global biosample management company dedicated to innovation in [...]

A new study, 'A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer,' is now available (see [...]

This release is available in French and Japanese, and Spanish. In 2007, researchers were dazzled by the degree to which genomes differ from one human to another and began to [...]

"Current L1 virus-like particle (VLP) vaccines provide type-restricted protection against a small subset of the human papillomavirus (HPV) genotypes associated with cervical cancer, necessitating continued cytologic screening of vaccinees (see [...]

In a study published in the Nov. 13 issue of Cancer Cell, researchers at Cincinnati Children's Hospital Medical Center reported that they have discovered that targeting and inactivating two genes [...]

Data detailed in 'Geographic distribution of cervical cancer-associated human leucocyte antigens and cervical cancer incidence in Finland' have been presented (see also Cancer Vaccines). According to recent research from Oulu, [...]

Both viruses and cancers subvert the growth-control machinery in a cell to serve their own needs. According to a new study, at least one virus uses mimicry to gain access [...]

Researchers detail in 'Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen-specific CD8+ T-cell response and inhibits the PSCA+ tumors growth in mice,' new [...]

New research, 'Gene therapy and active immune therapy of hematologic malignancies,' is the subject of a report (see also Cancer Gene Therapy Vaccines). "'Gene therapy for patients with hematologic malignancies, [...]

Scientists discuss in "Control of human mesothelin-expressing tumors by DNA vaccines" new findings in cancer gene therapy. "Mesothelin has been implicated as a potential ideal target antigen for the development [...]

Data detailed in "Expression of a functional CCR7 chemokine receptor inhibits the post-intravasation steps of metastasis in malignant murine mammary cancer cells" have been presented. In this recent study, researchers [...]

Research findings, "Control of Her-2 tumor immunity and thyroid autoimmunity by MHC and regulatory T cells," are discussed in a new report. According to a study from the United States, [...]