1. Squamous cell carcinoma in the Afro-Caribbean community: an 11-year retrospective study
- Author
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Benoit Tressières, Lucie Bonnecarrère, N. Cordel, Cancer et Environnement Localisation Tête et Cou (CELTEC), Université des Antilles (UA)-CHU Pointe-à-Pitre/Abymes [Guadeloupe], Service de Dermatologie et Médecine Interne [Pointe-à-Pitre, Guadeloupe], CHU Pointe-à-Pitre/Abymes [Guadeloupe], African Caribbean Cancer Consortium [Pointe-à-Pitre, Guadeloupe], Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Cancer et Environnement Localisation Tête et Cou [UR5_1] (CELTEC), CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA), and CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG)
- Subjects
squamous cell carcinoma ,Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Bowen disease ,Population ,Black People ,Dermatology ,Afro-Caribbean ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine ,Carcinoma ,Humans ,education ,Guadeloupe ,Aged ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Incidence ,HPV infection ,Retrospective cohort study ,Middle Aged ,medicine.disease ,3. Good health ,Surgery ,Infectious Diseases ,Private practice ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Skin cancer ,business - Abstract
Squamous cell carcinoma (SCC) is considered the most frequent skin cancer in Black people. Its incidence is not known in the Afro-Caribbean population.To assess the incidence of SCC in Guadeloupe, the largest island of the Lesser Antilles (405 000 inhabitants, mostly Black people of African and European descent). The second objective was to characterize clinical and histological patterns of SCC occurring in the Afro-Caribbean community.This retrospective study was conducted over an 11-year period (2000-2010). Data regarding 723 histological confirmed cases of SCC identified using the three Guadeloupean pathology laboratories' computerized databases were retrieved from the records of 551 patients. Private practice dermatologists and general practitioners were contacted to obtain any missing data.The annual age-adjusted incidence of SCC was 15 per 100.000 residents in Guadeloupe. In the Afro-Caribbean community, SCC had a greater size (i.e. 2.8 ± 2.8 cm vs. 1.5 ± 1.0 cm, P0.001), was more often located on the anogenital area (i.e. 48/79-60.8% vs. 14/320-4.4%, P0.001) in association with an underlying dermatosis due to HPV infection (15/71-21.1% vs. 3/366, 0.8%, P0.001) and led more frequently to metastasis (13/84-15.5% vs. 10/366-2.7%, P0.001) and/or fatal evolution (11/83-13.3% vs. 7/365-1.9%, P0.001).The results of this original study, which first estimated the incidence of SCC in West Indies, suggest that anogenital examination should be routinely performed in skin cancer screening of Afro-Caribbean people to detect the presence of SCC at an early stage.Squamous cell carcinoma is the most frequent skin cancer in Black people. Its incidence is not known in the Afro-Caribbean population. In Guadeloupe, the largest island of the Lesser Antilles, the annual age-adjusted incidence of SCC was estimated to be 15.0 per 100 000 residents, 95% CI:[13.8; 16.2]. In the Guadeloupean Afro-Caribbean community, SCC seems to more frequently occur in the anogenital area, due to HPV infection. These results support to include a routine genital urinary examination in the skin cancer screening of people of Afro-Caribbean descent.
- Published
- 2016
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