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In this paper, we outline a transdisciplinary approach and design thinking methodology (TADTM) to tackle complex problems. Our premise is that these problems need a fundamental understanding of technological solutions and those for human interactions, business operations, financing, socioeconomic governance, legislation, and regulations. They must be approached by different decisionmakers from different disciplines to establish seamless interactions and structured teamwork. In this regard, we emphasize the need for a transdisciplinary framework that accounts for personal preferences based on human behavior as well as the traditional interdisciplinary frameworks. To test and prove our hypothesis, three case studies are discussed. Case Study 1 is based on our studies at a major medical establishment, and Case Study 2 is about the integrated engineering and architecture approach we used at our university campus. Case Study 3 is based on an ongoing project to lead industrial corporations to change their energy policies with practical energy efficiency measures and by adapting renewable/alternative energy adaptations for their operations. Developing creative solutions and strategies to decrease atmospheric greenhouse gas emissions requires such an energy transition framework and should involve every person, company, entity, and all governments. It can only be achieved with efforts on both local and global levels, which needs to convince (a) industries to change their traditional operation modalities, (b) people to alter their consumption behaviors, and (c) governments to change their rules, regulations, and incentives. The complexity and magnitude of this enormous task demand the coordination and collaboration of all stakeholders, as well as the need for technological innovations.