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35 results on '"Canales-Ochoa, Nalia"'

2. COVID-19 Impacts the Mental Health and Speech Function in Spinocerebellar Ataxia Type 2: Evidences from a Follow-Up Study

Author

Velázquez-Pérez, Luis, Rodríguez-Labrada, Roberto, Gonzalez-Garcés, Yasmany, Canales-Ochoa, Nalia, Medrano-Montero, Jacqueline, Domínguez-Barrios, Yennis, Carrillo-Rodes, Frank J., Ramírez-Bautista, María B., Caballero-Laguna, Alberto, Gámez-Rodríguez, Osiel, Hernández-Oliver, María O., Sosa-Cruz, Yamilca, Zayas-Hernández, Arianna, Vázquez-Mojena, Yaimeé, Ziemann, Ulf, and Auburger, Georg

Published
2024
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4. Impacts of the COVID-19 Pandemic on the Mental Health and Motor Deficits in Cuban Patients with Cerebellar Ataxias

Author

González-Garcés, Yasmany, Domínguez-Barrios, Yennis, Zayas-Hernández, Arianna, Sigler-Villanueva, Aldo A., Canales-Ochoa, Nalia, Hernández Oliver, María O., Ramírez-Bautista, María B., Caballero-Laguna, Alberto, Arrufat-Pie, Eduardo, Carrillo-Rodes, Frank J., Medrano-Montero, Jacqueline, Rodríguez-Álvarez, Yanela, Gámez-Rodríguez, Osiel, Guerra-Rondón, Leonardo A., Aguilera-Batista, Osvaldo, Vazquez-Mojena, Yaimee, Rodríguez-Labrada, Roberto, and Velázquez-Pérez, Luis

Published
2021
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6. Structural Brain Correlates of Sleep Microstructure in Spinocerebellar Ataxia Type 2 and its role on clinical phenotype

Author

Rodriguez-Labrada, Roberto, primary, Canales-Ochoa, Nalia, additional, Galicia-Polo, Maria de Lourdes, additional, Cruz-Rivas, Edilia, additional, Romanzetti, Sandro, additional, Peña-Acosta, Arnoy, additional, Estupiñan-Rodriguez, Annelié, additional, Vázquez-Mojena, Yaimeé, additional, Dogan, Imis, additional, Auburger, Georg, additional, Reetz, Kathrin, additional, and Velazquez-Perez, Luis, additional

Published
2023
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12. Erythropoietin in Spinocerebellar Ataxia Type 2: Feasibility and Proof‐of‐Principle Issues from a Randomized Controlled Study

Author

Rodriguez‐Labrada, Roberto, primary, Ortega‐Sanchez, Ricardo, additional, Hernández Casaña, Patricia, additional, Santos Morales, Orestes, additional, Padrón‐Estupiñan, Maria del Carmen, additional, Batista‐Nuñez, Maricela, additional, Jiménez Rodríguez, Daise, additional, Canales‐Ochoa, Nalia, additional, Peña Acosta, Arnoy, additional, Medrano Montero, Jacqueline, additional, Labrada Aguilera, Pedro Enrique, additional, Estupiñán Rodriguez, Annelie, additional, Vazquez‐Mojena, Yaimee, additional, Almaguer Gotay, Dennis, additional, Aymed‐García, Judey, additional, García‐García, Idrian, additional, Torres Vega, Reydenis, additional, Viada González, Carmen, additional, Valenzuela Silva, Carmen M., additional, Silva Ricardo, Yanelis, additional, Columbié Ximelis, Jorge, additional, Tribin Rivero, Kenia, additional, Valle Cabrera, Roselin, additional, García‐Rodriguez, Julio Cesar, additional, Crombet Ramos, Tania, additional, Amaro‐González, Daniel, additional, Rodriguez‐Obaya, Teresita, additional, and Velázquez‐Pérez, Luis, additional

Published
2022
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14. Comprehensive Study of Early Features in Spinocerebellar Ataxia 2: Delineating the Prodromal Stage of the Disease

Author

Velázquez-Pérez, Luis, Rodríguez-Labrada, Roberto, Cruz-Rivas, Edilia M., Fernández-Ruiz, Juan, Vaca-Palomares, Israel, Lilia-Campins, Jandy, Cisneros, Bulmaro, Peña-Acosta, Arnoy, Vázquez-Mojena, Yaimeé, Diaz, Rosalinda, Magaña-Aguirre, Jonathan J., Cruz-Mariño, Tania, Estupiñán-Rodríguez, Annelié, Laffita-Mesa, José M., González-Piña, Rigoberto, Canales-Ochoa, Nalia, and González-Zaldivar, Yanetza

Published
2014
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17. Cognitive Decline Is Closely Associated with Ataxia Severity in Spinocerebellar Ataxia Type 2: a Validation Study of the Schmahmann Syndrome Scale

Author

Rodríguez-Labrada, Roberto, primary, Batista-Izquierdo, Alejandro, additional, González-Melix, Zuleyra, additional, Reynado-Cejas, Lorenzo, additional, Vázquez-Mojena, Yaimeé, additional, Sanz, Yuri Arsenio, additional, Canales-Ochoa, Nalia, additional, González-Zaldívar, Yanetza, additional, Dogan, Imis, additional, Reetz, Kathrin, additional, and Velázquez-Pérez, Luis, additional

Published
2021
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19. Oral Zinc Sulphate Supplementation for Six Months in SCA2 Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Author

Velázquez-Pérez, Luis, Rodríguez-Chanfrau, Jorge, García-Rodríguez, Julio Cesar, Sánchez-Cruz, Gilberto, Aguilera-Rodríguez, Raúl, Rodríguez-Labrada, Roberto, Rodríguez-Díaz, Julio Cesar, Canales-Ochoa, Nalia, Gotay, Dennis Almaguer, Almaguer Mederos, Luis E., Laffita Mesa, José M., Porto-Verdecia, Marlene, Triana, Consuelo González, Pupo, Noemí Rodríguez, Batista, Idania Hidalgo, López-Hernandez, Orestes D., Polanco, Iverlis Díaz, and Novas, Arelis Jayme

Published
2011
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20. Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study.

Author

Rodriguez-Graña, Tania, Rodríguez-Labrada, Roberto, Santana-Porbén, Sergio, Reynaldo-Cejas, Lorenzo, Medrano-Montero, Jacqueline, Canales-Ochoa, Nalia, Silva-Ricardo, Yanelis, Torres-Vega, Reidenis, González-Zaldivar, Yanetza, Almaguer-Gotay, Dennis, Auburger, Georg, and Velázquez-Pérez, Luis

Subjects
SPINOCEREBELLAR ataxia, WEIGHT loss, CALF muscles, NUTRITIONAL assessment, MUSCLE mass, BODY mass index
Abstract

Body weight changes occur frequently during advanced stages of Spinocerebellar Ataxia type 2 (SCA2), nevertheless limited information exists on biomarkers of nutritional status of these patients. To assess changes in surrogate nutritional markers of SCA2 patients; to explore their associations with expanded CAG repeats and disease severity. One-hundred-thirteen SCA2 patients and 50 healthy controls underwent a comprehensive anthropometrical and biochemical assessment protocol of the nutritional status. Neurological and genotype assessments were also performed. A decrease in weight, body mass index (BMI), cutaneous skinfold thickness, fat mass, arm muscle circumference, calf circumference and skeletal muscle mass was observed in SCA2 patients compared to the controls. The total/HDL cholesterol ratio was significantly reduced in patients. BMI was correlated with the age at onset. Overall, anthropometric measures were correlated with clinical markers of disease severity and were more evident in severe and moderate cases. Using anthropometric measures in the assessment of the nutritional status of SCA2 patients might provide hints about pathophysiological mechanisms that underlie metabolic abnormalities in SCA2. Anthropometric are close related with disease severity and progression, and trigger preventive therapies aimed to ameliorate weight loss and wasting in these patients. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study

Author

Rodriguez-Graña, Tania, primary, Rodríguez-Labrada, Roberto, additional, Santana-Porbén, Sergio, additional, Reynaldo-Cejas, Lorenzo, additional, Medrano-Montero, Jacqueline, additional, Canales-Ochoa, Nalia, additional, Silva-Ricardo, Yanelis, additional, Torres-Vega, Reidenis, additional, González-Zaldivar, Yanetza, additional, Almaguer-Gotay, Dennis, additional, Auburger, Georg, additional, and Velázquez-Pérez, Luis, additional

Published
2021
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24. Involvement of the Auditory Pathway in Spinocerebellar Ataxia Type 7.

Author

Ramos-Languren, Laura E., Rodríguez-Labrada, Roberto, Magaña, Jonathan J., Canales-Ochoa, Nalia, González-Zaldivar, Yanetza, Velázquez-Pérez, Luis, and González-Piña, Rigoberto

Subjects
AUDITORY pathways, SPINOCEREBELLAR ataxia, CENTRAL nervous system, INDIVIDUALIZED medicine, BRAIN stem, AGE of onset
Abstract

Background: Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant disorder caused by a mutation in the ATXN7 gene. The involvement of the brainstem auditory pathway in pathogenesis of this disease has not been systematically assessed. Aim: To determine involvement of the brainstem auditory pathway in SCA7 patients and its relationship to clinical features of the disease. Methods: In this case-control study, brainstem auditory-evoked potentials (BAEPs) were assessed in 12 SCA7 patients with clinical and molecular diagnosis, compared to 2 control groups of 16 SCA2 patients and 16 healthy controls. Results: SCA7 patients exhibited significant prolongation of I-wave and III-wave latencies, whereas SCA2 patients showed increased latencies for III and V waves and I–III interpeak interval. SCA7 patients with larger I-wave latencies exhibited larger CAG repeats, earlier onset age, and higher SARA scores, but in SCA2 cases, these were not observed. Conclusions: BAEP tests revealed functional involvement of the auditory pathway in SCA7 (mainly at) peripheral portions, which gave new insights into the disease physiopathology different from SCA2 and may unravel distinct pathoanatomical effects of polyQ expansions in the central nervous system. Significance: These findings offer important insights into the distinctive disease mechanisms in SCA7 and SCA2, which could be useful for differential diagnosis and designing specific precision medicine approaches for both conditions. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Sleep spindles and K-complex activities are decreased in spinocerebellar ataxia type 2: relationship to memory and motor performances

Author

Rodríguez-Labrada, Roberto, primary, Galicia-Polo, Lourdes, additional, Canales-Ochoa, Nalia, additional, Voss, Ursula, additional, Tuin, Inca, additional, Peña-Acosta, Arnoy, additional, Estupiñán-Rodriguez, Annelié, additional, Medrano-Montero, Jacqueline, additional, Vázquez-Mojena, Yaimeé, additional, González-Zaldivar, Yanetza, additional, Auburger, Georg, additional, and Velázquez-Pérez, Luis, additional

Published
2019
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26. Hereditary Ataxias in Cuba: A Nationwide Epidemiological and Clinical Study in 1001 Patients.

Author

Velázquez-Pérez, Luis, Medrano-Montero, Jacqueline, Rodríguez-Labrada, Roberto, Canales-Ochoa, Nalia, Campins Alí, Jandy, Carrillo Rodes, Frank J, Rodríguez Graña, Tania, Hernández Oliver, María O., Aguilera Rodríguez, Raul, Domínguez Barrios, Yennis, Torres Vega, Reydenis, Flores Angulo, Lissi, Cordero Navarro, Noharis Y., Sigler Villanueva, Aldo A., Gámez Rodríguez, Osiel, Sagaró Zambrano, Ilya, Navas Napóles, Nayime Y., García Zacarías, Javier, Serrano Barrera, Orlando R., and Ramírez Bautista, María B.

Subjects
MEDICAL care research, SPINOCEREBELLAR ataxia, EYE movement disorders, DISEASE duration, CEREBELLUM degeneration, RESEARCH institutes, TREMOR
Abstract

The prevalence estimations of hereditary ataxias are biased since most epidemiological studies are confined to isolated geographical regions and few nationwide studies are available. The study aims to assess the prevalence, distribution, and neurological features of the Cuban population with hereditary ataxias. A nationwide epidemiological study of hereditary ataxias was conducted in Cuba between March 2017 and June 2018. Patients were scheduled at the Cuban ataxia research center, various hospitals, or at their homes. Demographic and clinical variables were obtained through standardized questionnaires and validated clinical tools. Overall, 1001 patients were diagnosed with hereditary ataxias for a nationwide prevalence of 8.91 cases/100.000 inhabitants. Spinocerebellar ataxia type 2 (SCA2) was the commonest subtype, with highest prevalences at Holguín province (47.86/100.000), and a broad dissemination in the whole country. Most of neurological features were common between all SCA cohorts, but the frequencies of some of them varied between distinct subtypes. Within the SCA2 cohort, significant influences of long mutation size and higher disease duration over the muscle atrophy and oculomotor disorders were observed. Besides, higher disease durations were associated with resting tremor and dysphagia, whereas shorter disease durations were associated with hyperreflexia. The spreading of SCA2 to whole country and the documented raising of its prevalence set the rationales for higher-scope medical care and research strategies, supported in collaborative research networks. The wide epidemiological, clinical, and genetic characterization of this founder SCA2 population identifies this homogeneous cohort as an attractive source for the development of future clinical-genetic and therapeutic researches. [ABSTRACT FROM AUTHOR]

Published
2020
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27. Neurorehabilitation therapy in spinocerebellar ataxia type 2: A 24-week, rater-blinded, randomized, controlled trial

Author

Rodríguez-Díaz, Julio Cesar, primary, Velázquez-Pérez, Luis, additional, Rodríguez Labrada, Roberto, additional, Aguilera Rodríguez, Raúl, additional, Laffita Pérez, Dalina, additional, Canales Ochoa, Nalia, additional, Medrano Montero, Jacqueline, additional, Estupiñán Rodríguez, Annelié, additional, Osorio Borjas, Marcos, additional, Góngora Marrero, Mariela, additional, Reynaldo Cejas, Lorenzo, additional, González Zaldivar, Yanetza, additional, and Almaguer Gotay, Dennis, additional

Published
2018
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29. Corticomuscular Coherence: a Novel Tool to Assess the Pyramidal Tract Dysfunction in Spinocerebellar Ataxia Type 2

Author

Velázquez-Pérez, Luis, primary, Tünnerhoff, Johannes, additional, Rodríguez-Labrada, Roberto, additional, Torres-Vega, Reidenis, additional, Belardinelli, Paolo, additional, Medrano-Montero, Jacqueline, additional, Peña-Acosta, Arnoy, additional, Canales-Ochoa, Nalia, additional, Vázquez-Mojena, Yaimeé, additional, González-Zaldivar, Yanetza, additional, Auburger, Georg, additional, and Ziemann, Ulf, additional

Published
2016
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30. Epidemiological, clinical, and molecular characterization of Cuban families with spinocerebellar ataxia type 3/Machado-Joseph disease

Author

González-Zaldívar, Yanetza, primary, Vázquez-Mojena, Yaimeé, additional, Laffita-Mesa, José M, additional, Almaguer-Mederos, Luis E, additional, Rodríguez-Labrada, Roberto, additional, Sánchez-Cruz, Gilberto, additional, Aguilera-Rodríguez, Raúl, additional, Cruz-Mariño, Tania, additional, Canales-Ochoa, Nalia, additional, MacLeod, Patrick, additional, and Velázquez-Pérez, Luis, additional

Published
2015
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31. Caracterización integral de la ataxia espinocerebelosa 2 en Cuba y su aplicación en proyectos de intervención

Author

Velázquez Pérez, Luis, primary, Rodríguez Labrada, Roberto, additional, Sánchez Cruz, Gilberto, additional, Laffita Mesa, José M, additional, Almaguer Mederos, Luis, additional, Aguilera Rodríguez, Raúl, additional, Medrano Montero, Jacqueline, additional, Almaguer Gotay, Dennis, additional, Cruz Mariño, Tania, additional, González Zaldívar, Yanetza, additional, Coello Almarales, Dany, additional, Canales Ochoa, Nalia, additional, Vázquez Mojena, Yaimeé, additional, and Rodríguez Díaz, Julio Cesar, additional

Published
2011
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32. Sleep Disorders in Spinocerebellar Ataxia Type 2 Patients

Author

Velázquez-Pérez, Luis, primary, Voss, Ursula, additional, Rodríguez-Labrada, Roberto, additional, Auburger, Georg, additional, Canales Ochoa, Nalia, additional, Sánchez Cruz, Gilberto, additional, Galicia Polo, Lourdes, additional, Haro Valencia, Reyes, additional, Aguilera Rodríguez, Raúl, additional, Medrano Montero, Jacqueline, additional, Laffita Mesa, Jose M., additional, and Tuin, Inka, additional

Published
2011
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33. Uncommon features in Cuban families affected with Friedreich ataxia

Author

Cruz-Mariño, Tania, primary, González-Zaldivar, Yanetza, additional, Laffita-Mesa, Jose Miguel, additional, Almaguer-Mederos, Luis, additional, Aguilera-Rodríguez, Raul, additional, Almaguer-Gotay, Dennis, additional, Rodríguez-Labrada, Roberto, additional, Canales-Ochoa, Nalia, additional, MacLeod, Patrick, additional, and Velázquez-Pérez, Luis, additional

Published
2010
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