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Purpose: Many studies have investigated the effect of Helicobacter pylori (H. pylori) colonization on the development of allergic diseases, but with conflicting results. The purpose of this cross-sectional observation study is to estimate H. pylori prevalence in allergic and nonallergic nasal conditions and compare with normal population., Methods: 274 patients were tested for H. pylori with stool antigen test. Patients were compared with the control group for H. pylori positivity rates after they were categorized according to their primary diagnoses as mite allergy, pollen allergy, mite and pollen allergy, and non-allergic rhinitis with eosinophilic syndrome (NARES). Results were also classified according to age., Results: The number of H. pylori-positive patients with mite allergy, mite and pollen allergy, and NARES were significantly higher than the control group in sadults. The percentages of patients in the pediatric group who had mite allergy, pollen allergy, mite and pollen allergy, or NARES were not significantly different when compared to the control group., Conclusion: Forthcoming studies would undoubtedly evaluate of the profits of treating allergic nasal conditions by treating the aforementioned bacterial infection.

Background: The objective of this work was to determine the role of nasal sound analysis using a software called Odiosoft-Rhino (OR) in evaluation of nasal erectile elements as a cause of nasal obstruction. Comparisons of nasal resistance, amplitude of the nasal sound frequency spectra, and visual analogue score (VAS) were made., Methods: Nasal endoscopy, VAS, rhinomanometry (RMM), and OR were performed on 64 patients with inferior turbinate hypertrophy but without any other nasal problems, both untreated and 15 minutes after the application of topical decongestants (TDs). Results were compared and any correlation was investigated., Results: For inspiration, the OR intervals for both sides at all 5 frequency intervals changes significantly with decongestion, except for the left side at 0.5 to 1 kHz. For expiration, the OR intervals for both sides changed significantly for 0.2 to 0.5 KHz and 2 to 4 kHz, but not for the other 3 frequency intervals. VAS correlated well with physical examination, both inspiratory and expiratory RMM, and 2 to 4 kHz inspiratory and expiratory nasal sound on both sides both before and after TD application. The 2 to 4 kHz inspiratory and expiratory nasal sound on both sides correlated well with inspiratory and expiratory RMM on both sides both before and after TD application., Conclusion: OR is an efficient and reliable method to evaluate the role of the erectile components in nasal patency in the absence of allergy or septal deviation. It is practical and may be used in routine clinical practice., (© 2014 ARS-AAOA, LLC.)

Objective: To conduct a preliminary study testing the validity of the Odiosoft-Rhino (OR) in the evaluation of nasal patency in patients with nasal septal deviation and compare the results with visual analogue score (VAS) of nasal obstruction and rhinomanometry (RMM)., Methods: OR and RMM were performed on 68 patients with nasal septal deviation and 61 healthy controls. VAS, nasal resistance values and nasal sound analysis were noted for the left and right nasal cavities., Results: There are statistically significant differences between VAS, RMM and nasal endoscopic findings between the patient and the control group. The OR results at expiratory and inspiratory 2000 - 4000 Hz and 4000 - 6000 Hz intervals for both nasal cavities show a statistically significant difference between the patient and control groups. Nasal endoscopic findings, RMM, OR results of the deviated sides in the 2000 - 4000 Hz interval correlate well with VAS., Conclusions: OR may be a practical test in assessment of nasal patency. OR at the 2000 - 4000 Hz interval shows a correlation with VAS. However, showing a correlation between a test and a variable is not the same as proving that it is a useful diagnostic test. Therefore, more studies with larger series are needed.

Background: The objective assessment of nasal patency is a common challenge in clinical practice. This study was designed to show and compare the values of active anterior rhinomanometry (RMM) in patients with sensation of nasal obstruction., Methods: According to the physical examination, 7283 individuals with sensation of nasal obstruction were divided into the nasal septal deviation (NSD) group and normal nasal anatomy group. The NSD group and normal nasal anatomy group were further divided into subgroups according to skin-prick test positivity or negativity, respectively. Nasal airway resistances (NARs) of the subgroups were evaluated and compared., Results: The mean value of total inspiratory NAR was 0.51 and 0.34 Pa/cm3 per second at 150-Pa pressure point in allergic rhinitis subjects with and without NSD, respectively; 0.48 and 0.32 Pa/cm3 per second were the mean values of total inspiratory NAR in nonallergic rhinitis subjects with and without NSD, respectively. The total inspiratory resistances in groups with NSD were significantly higher than the others., Conclusion: We believe that the results of so large a number of participants in this test will make an obvious contribution to the medical literature.

Objectives: To detect the nasal cycle in healthy subjects while they were performing their daily activities, using the Odiosoft-Rhino (OR) software program and to investigate the ability of the OR program to perform this procedure., Design: Prospective analysis., Setting: Tertiary referral center., Patients: Twenty healthy adult volunteers., Interventions: Investigation of the nasal cycles of volunteers by the OR program every 30 minutes over a period of 12 hours on 4 different days in the same week. Each subject performed expiration every 30 minutes into a microphone, and the nasal sounds were recorded separately for each nasal cavity., Main Outcome Measures: The OR data collected during 12 hours for 4 days were analyzed for cyclic nasal obstruction., Results: The nasal sounds were calculated for each of the nasal cavities and a 2000- to 4000-Hz frequency interval was used for evaluation. In all of the individuals investigated in this study, a cyclic change of nasal patency was detected by the OR program. All of the data were calculated to be significantly different for each nasal cavity (P < .05 for all comparisons). Changes of nasal sounds and comparison of the 2 sides demonstrated that the total amount of cyclic changes ranged between 30 minutes and 2 to 2.5 hours., Conclusions: With the help of the OR program, we detected the nasal cycles in all of the volunteers, and the periods were not less than 30 minutes or more than 2.5 hours. Because the data collection period was long and the patient compliance was maximal, we believe that the results in the study are more reliable and natural.

We studied 63 adults with perennial allergic rhinitis and positive skin-prick tests for Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df) who had not previously received any type of immunotherapy or pharmacotherapy for their condition. We injected these patients with a 50% Dp/50% Df modified allergen intradermally in accordance with the classic immunotherapy scheme once a week for 30 months. Specific immunotherapy (SIT) was administered until the specific IgG (sIgG) concentration reached level IV (>or=81% absorbance). We measured specific IgE and sIgG levels, obtained skin-prick test results, and evaluated clinical symptoms and signs before immunotherapy, at 6 months into therapy, at the completion of therapy (30 mo), and 1 year after the completion of therapy. In the group as a whole, differences between mean sIgG values and mean skin-prick test results before and after SIT were statistically significant (p < 0.05). At the 1-year follow-up, there was a negative correlation between sIgG levels and clinical symptom and sign scores, a positive correlation between skin-prick test results and clinical improvement, and a negative correlation between sIgG levels and skin-prick test results. Individually, at the 1-year follow-up, 50 of the 63 patients (79%) had experienced a resolution of clinical symptoms and/or signs and were thus deemed to have achieved clinical recovery.

Background: Evaluation of a recently developed method for measuring nasal obstruction., Objective: To investigate the reliability of a new software program called Odiosoft-Rhino (OR) as a presumptive diagnostic method to evaluate the nasal airflow of patients who have nasal septal deviation and to compare OR results with the acoustic rhinometry (AR) results and visual analogue scale (VAS) of nasal obstruction., Setting: Referral centre, institutional practice., Methods: OR uses a software program to analyze the original sounds of nasal airflow and evaluate the sounds of both nasal inspiration and expiration and then performs spectral and frequency analysis. OR and AR were performed on 56 patients with nasal septal deviations and 52 healthy controls. Their VAS, minimal cross-sectional area (MCA)1, and MCA2 measurements and nasal expiratory sound analysis between 200 to 500, 500 to 1000, 1000 to 2000, 2000 to 4000, and 4000 to 6000 Hz frequencies were noted for the left and right nasal cavities., Main Outcome Measure: Assessment and comparison of nasal obstruction with OR and AR methods., Results: There was a significant difference between the MCA1 and MCA2 values and the nasal expiratory sound intensity of the deviated patients at 200 to 500, 500 to 1000, 1000 to 2000, and 2000 to 4000 Hz of the patient group and the control group (p < .001). There was a correlation between the OR results of 2000 to 4000 and 4000 to 6000 Hz intervals and the MCA1 results of the deviated sides. From the receiver operating characteristic curve analysis, the pooled results showed that 81.8% of deviated patients in the 2000 to 4000 Hz frequency range were found under the curve (p < .001). Related to this, 83.4% sensitivity and 82.1% specificity with a 14.5 dB cutoff point were determined., Conclusion: The OR test is noninvasive and requires little cooperation. The sensitivity and specificity of the OR test are reliable, so we could propose to use OR as a new diagnostic method to evaluate the nasal airflow in clinical practice. However, more studies with wider series and some technical modification are needed.

Conclusion: Odiosoft-Rhino (OR) is a non-invasive test that is completed in an extremely short period of time. It is easy to perform and little patient cooperation is needed. OR is safe and could be used in the rhinological setting if further improved., Objective: To evaluate nasal obstruction objectively with a new technique, OR, and to compare the results with a widely accepted method, rhinomanometry, in normal subjects., Subjects and Methods: OR and anterior RMM were performed in 79 subjects without any rhinologic symptoms and signs. Visual analogue scales (VAS) of nasal obstruction, nasal airway resistance and nasal expiratory and inspiratory sounds were analysed., Results: VAS of nasal obstruction was found to be correlated with OR findings of expiration at 2000-4000 Hz frequency interval on both sides (r = 0.564, p < 0.01 for the left side, r = 0.533, p < 0.01 for the right side). Correlations were found (p < 0.05) between left 2000-4000 Hz in expiration OR and left expiration RMM, left 4000-6000 Hz in expiration OR and left expiration RMM, right 2000-4000 Hz in expiration OR and right expiration RMM, and right 4000-6000 Hz in expiration OR and right expiration RMM. No correlation was seen between VAS, anterior RMM and OR at inspiration in any interval.

Background: Both sublingual and subcutaneous immunotherapies have a documented clinical efficacy, but only a few comparative studies have been performed., Objectives: To evaluate and compare the long-term efficacies of subcutaneous and sublingual immunotherapy., Methods: One hundred and ninety-three patients with house dust mite allergies, out of an original total of 230, were treated with subcutaneous and sublingual house dust mite-specific immunotherapies for 3 years and also observed for 3 years after discontinuation of the treatment. The patients were randomized into 2 groups: the sublingual group (97 patients) and the subcutaneous group (96 patients). The therapy's success was evaluated using the symptom score, skin prick test results, and the nasal allergen challenge score. The patients were evaluated at the beginning of the study, at the end of years 1, 2, and 3, and also at the end of the 1st and 3rd years after discontinuation of the specific immunotherapy treatment., Results: Immunotherapy induced a significant improvement during the treatment and the follow-up period. We found a greater improvement in the subcutaneous group compared to the sublingual group when we looked at the comparative results of the total 6 years., Conclusion: We suggest subcutaneous immunotherapy for patients with perennial allergic rhinitis due to the better results that were obtained during our study period. Nevertheless, sublingual immunotherapy is now accepted by WHO as a valid alternative to the subcutaneous route and should be used in all patients who require immunotherapy and do not accept the subcutaneous route of allergen administration., (2008 S. Karger AG, Basel)

Background: Odiosoft-Rhino (OR) is new software and equipment that can be used to measure changes in nasal obstruction after intranasal steroid treatment. OR is a promising method for measuring the degree of nasal obstruction. OR can precisely analyze nasal sound spectra in decibels, which is generated by nasal airflow. We studied the reliability of OR for assessing declining nasal obstruction after budesonide nasal spray treatment., Methods: Sixty-five patients with perennial allergic rhinitis (PAR) were enrolled in the study, and 52 of these patients completed the study. Nasal endoscopic examination, acoustic rhinometry (AR), and OR were performed and symptom scores were compared before and after 3 months of treatment with intranasal budesonide. All of the patients received 7 days of placebo treatment before receiving budesonide., Results: There was a significant difference in the visual analog scores of nasal obstruction and in the examination scores before and after the treatment for both the right and the left nasal cavities. Pretreatment AR findings and OR findings in the 2000- to 4000-Hz and 4000- to 6000-Hz intervals for both sides were significantly different from the posttreatment measurements (p = 0.000). Both AR and OR can assess the efficacy of budesonide nasal spray treatment for nasal obstruction in patients with PAR., Conclusion: Both AR and OR are effective for assessing nasal obstruction and monitoring treatment efficacy but, as a simple and noninvasive test, OR can be used with confidence.

Objective: To evaluate the practicability of Odiosoft-Rhino (OR), a new experimental method for assessing the nasal airflow and resistance, in normal subjects and to compare the results with acoustic rhinometry (AR) findings., Study Design and Setting: OR and AR were carried out in 72 healthy subjects. Their visual analogue scales of nasal obstruction, minimal cross sectional areas (MCA(1) and MCA(2)), and nasal expiration sounds were analyzed and noted for both nasal cavities., Results: Statistically significant correlations (P < 0.05) were found between OR and AR in 2,000 to 4,000 Hz and 4,000 to 6,000 Hz with MCA(1) and MCA(2)., Conclusions: OR is a noninvasive and rapid test. It is easy to carry out and requires little patient cooperation. It seems that it may give compatible results with other reliable methods that assess nasal airflow., Significance: We assume that OR is a sensitive method for evaluating nasal airflow in normal subjects in an easy way., Ebm Rating: A-1b.