20 results on '"Can, Pang"'
Search Results
2. One-pot synthesis of 2,6-diaryl-4,5-dihydropyridazin-3(2H)-ones: Copper catalyzed annulation of aldehydes, arylhydrazines and 3-acryloyloxazolidin-2-one
- Author
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Jianbo Zhao, Shengshu Lei, Min Wu, Can Pang, and Hao Li
- Subjects
Organic Chemistry ,Drug Discovery ,Biochemistry - Published
- 2023
3. The significance of screening for microvascular diseases in Chinese community-based subjects with various metabolic abnormalities.
- Author
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Can Pang, Lili Jia, Xuhong Hou, Xin Gao, Wei Liu, Yuqian Bao, and Weiping Jia
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Medicine ,Science - Abstract
BACKGROUND: To assess the association of albuminuria and retinopathy with metabolic syndrome (MetS) and the related metabolic components defined by various criteria in Chinese community-based subjects. METHODS: A total of 3240 Chinese subjects were recruited from urban communities and classified into subgroups with isolated or concomitant state of the two microvascular diseases. MetS was defined according to the standard of International Diabetes Federation, the National Cholesterol Education Program's Adult Treatment Panel III and Chinese Diabetes Society (CDS), separately. Albuminuria was defined as an elevated morning urine albumin-to-creatinine ratio. Retinopathy were identified with nonmydriatic retinal photographs according to the Diabetic Retinopathy Disease Severity Scale. Logistic regression was performed to analyze the contributive risk factors. RESULTS: The subgroup of isolated retinopathy was the oldest (P
- Published
- 2014
- Full Text
- View/download PDF
4. Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults
- Author
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Can Pang, Xuhong Hou, Jungong Zhao, Cheng Hu, Jun Lu, Lei Zhang, Weiping Jia, and Yuqian Bao
- Subjects
Body surface area ,medicine.medical_specialty ,Waist ,business.industry ,Endocrinology, Diabetes and Metabolism ,Case-control study ,Type 2 Diabetes Mellitus ,030209 endocrinology & metabolism ,medicine.disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Blood pressure ,medicine.anatomical_structure ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,030211 gastroenterology & hepatology ,business ,Pancreas ,Body mass index - Abstract
AIMS This study aimed to compare pancreatic volume and its clinical significance among patients with type 2 diabetes mellitus (DM), adult-onset type 1 DM and latent autoimmune diabetes in adults (LADA). METHODS This is a cross-sectional study. One hundred twenty-six outpatients (68 with LADA and 58 with type 1 DM) and 158 inpatients (71 with type 2 DM and 87 non-diabetic controls) were recruited during May-July 2013 in Shanghai Jiao Tong University Affiliated Sixth People's Hospital. All the patients underwent abdominal computerized tomography; pancreatic volume was then calculated. RESULTS The mean pancreatic volume was highest in the controls, followed by those in patients with type 2 DM, LADA and type 1 DM. The pancreatic volume in LADA was comparable with that in type 2 DM but significantly greater than that in type 1 DM (p
- Published
- 2016
5. Associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults and type 2 diabetes
- Author
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Lei Zhang, Xuhong Hou, Yuqian Bao, Cheng Hu, Weiping Jia, Jun Lu, Can Pang, Jian Zhou, and Xiaoping Pan
- Subjects
medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Retrospective cohort study ,Diabetic retinopathy ,Type 2 diabetes ,medicine.disease ,Surgery ,Nephropathy ,Diabetic nephropathy ,Endocrinology ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Metabolic syndrome ,business ,Retinopathy - Abstract
Background This study aimed to assess the associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Methods This is a retrospective study. Our diabetes registry included 6975 patients aged 30–75 years old with phenotypic type 2 diabetes who underwent islet autoantibody screening between 2003 and 2012; 384 patients were identified to have LADA. Rates of chronic complications for LADA and type 2 diabetes were compared using a 1 : 2 matched design. Logistic models were fitted to identify the presence of chronic diabetic complications using clinical characteristics including gender, age, duration of diabetes, glycemic control and metabolic syndrome. Results When duration of diabetes is
- Published
- 2015
6. Determination of diabetic retinopathy prevalence and associated risk factors in Chinese diabetic and pre-diabetic subjects: Shanghai diabetic complications study
- Author
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Sunfang Jiang, Xin Gao, Hui-Lin Gu, Yuhua Zuo, Lili Jia, Qiang Wu, Wei Liu, Xuhong Hou, Can Pang, Yuqian Bao, Kun-san Xiang, and Weiping Jia
- Subjects
medicine.medical_specialty ,education.field_of_study ,Diabetic neuropathy ,business.industry ,Endocrinology, Diabetes and Metabolism ,Population ,Diabetic retinopathy ,medicine.disease ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Albuminuria ,Blood sugar regulation ,Glycated hemoglobin ,medicine.symptom ,business ,education ,Retinopathy - Abstract
Background The prevalence of diabetic retinopathy is not well studied in the Chinese pre-diabetic population, also known as impaired glucose regulation. Hence, we investigated the prevalence of and risk factors associated with retinopathy in diabetic and pre-diabetic subjects from Chinese communities. Methods A total of 3736 Chinese subjects were recruited from urban communities in Shanghai. The participants were classified as normal glucose tolerance, impaired glucose regulation (IGR) and diabetes based on the 75 g oral glucose tolerance test. The levels of diabetic retinopathy (DR) were assessed with non-mydriatic retinal photographs according to the Diabetic Retinopathy Disease Severity Scale. Results The prevalence of diabetic retinopathy in patients with diabetes and impaired glucose regulation subjects was 9.4% and 2.5%, respectively. In subjects with IGR, hypertension (odds ratio: 3.54, p = 0.028), including elevated systolic and diastolic blood pressure and obesity (odds ratio: 3.53, p = 0.028) were significantly associated with diabetic retinopathy after age and sex adjustments. The factors associated with retinopathy in diabetes included diabetes duration, blood glucose levels, glycated hemoglobin levels, and the presence of albuminuria. Diabetic retinopathy was significantly associated with fasting plasma glucose in known diabetes, whereas in newly-diagnosed subjects, diabetic neuropathy was closely correlated to postprandial plasma glucose. Conclusions Hyperglycemia was a strong risk factor for diabetic retinopathy. In pre-diabetic subjects, diabetic retinopathy was also associated with hypertension and obesity. Copyright © 2011 John Wiley & Sons, Ltd.
- Published
- 2012
7. CPVL/CHN2 Genetic Variant Is Associated With Diabetic Retinopathy in Chinese Type 2 Diabetic Patients
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Jie Wang, Cheng Hu, Rong Zhang, Congrong Wang, Weihui Yu, Xiaojing Ma, Can Pang, Yuqian Bao, Weiping Jia, and Kun-san Xiang
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Male ,China ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Carboxypeptidases ,Polymorphism, Single Nucleotide ,Severity of Illness Index ,Gastroenterology ,Nephropathy ,Amino Acyl-tRNA Synthetases ,Diabetic nephropathy ,Gene Frequency ,Internal medicine ,Diabetes mellitus ,Genetics ,Internal Medicine ,medicine ,Humans ,Genetic Association Studies ,Aged ,Diabetic Retinopathy ,business.industry ,Tumor Suppressor Proteins ,CPVL ,Case-control study ,Diabetic retinopathy ,Odds ratio ,Middle Aged ,medicine.disease ,Neoplasm Proteins ,Endocrinology ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,Insulin Receptor Substrate Proteins ,Female ,business ,Retinopathy - Abstract
OBJECTIVE Diabetic nephropathy and retinopathy are two important microvascular diabetes complications with a high concordance rate in diabetic patients. A recent genome-wide association study in type 1 diabetic patients of European descent identified four loci to be associated with diabetic nephropathy. The aim of this study was to test the effects of single nucleotide polymorphisms (SNPs) from these four loci on diabetic nephropathy and retinopathy in Chinese type 2 diabetic patients. RESEARCH DESIGN AND METHODS In stage 1, we recruited 1,276 type 2 diabetic patients, including 378 patients with diabetic nephropathy but no retinopathy, 374 patients with diabetic retinopathy but no nephropathy, 244 patients with both diabetic retinopathy and nephropathy, and 280 control subjects with diabetes for >10 years and no diabetic retinopathy or nephropathy. Fifty-five SNPs from four loci (CPVL/CHN2, FRMD3, CARS, and IRS2) were genotyped. The SNPs that showed associations to diabetic retinopathy or nephropathy were genotyped in stage 2 samples for replication. RESULTS SNPs from CPVL/CHN2 and FRMD3 were associated with diabetic retinopathy with rs39059 and rs10868025 as the top SNPs (odds ratio [OR] 1.292, 95% CI 1.097–1.523, P = 0.0022, for rs39059; 1.201, 1.014–1.422, P = 0.0343, for rs10868025) in stage 1 samples. In stage 2 analysis, only rs39059 showed similar effect to diabetic retinopathy (OR 1.269, 0.989–1.628, P = 0.0689), and meta-analysis showed a significant association between rs39059 and diabetic retinopathy, with an OR of 1.285 (1.120–1.474, P = 0.0003). CPVL/CHN2 rs39059 was also associated with levels of diabetic retinopathy (P = 0.0007 for trend). However, no association was detected between these SNPs and diabetic nephropathy. CONCLUSIONS In this study, we found CPVL/CHN2 rs39059 was associated with diabetic retinopathy in the Chinese type 2 diabetic patients.
- Published
- 2011
8. Case report
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Huizheng Zhang, Bomin Guo, Yuqian Bao, Xianzhao Deng, Can Pang, Youben Fan, Jie Kang, and Haoyong Yu
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Adenoma ,Parathyroidectomy ,medicine.medical_specialty ,endocrine system diseases ,medicine.medical_treatment ,Normal parathyroid hormone ,Urology ,Parathyroid hormone ,030209 endocrinology & metabolism ,Time-to-Treatment ,Parathyroid Glands ,03 medical and health sciences ,0302 clinical medicine ,parathyroid adenoma ,medicine ,Humans ,parathyroid hormone ,Clinical Case Report ,primary hyperparathyroidism ,Monitoring, Physiologic ,Ultrasonography ,Parathyroid adenoma ,Tomography, Emission-Computed, Single-Photon ,Incidental Findings ,medicine.diagnostic_test ,business.industry ,hypercalcemia ,Normal level ,General Medicine ,Middle Aged ,medicine.disease ,Parathyroid Neoplasms ,Treatment Outcome ,Diabetes Mellitus, Type 2 ,030220 oncology & carcinogenesis ,Female ,Diabetic patient ,business ,hormones, hormone substitutes, and hormone antagonists ,Primary hyperparathyroidism ,Emission computed tomography ,Research Article - Abstract
Rationale: Parathyroid hormone PTH) levels are the main parameters to differentiate primary hyperparathyroidism (PHPT) from non-PTH-dependent hypercalcemia. We report a case of hypercalcemia with normal PTH levels due to a parathyroid adenoma. Patient concerns: A 52-year-old female patient presented with 2-year history of documented sustained high-normal serum calcium and hypercalcemia (2.51–3.03 mmol/L) with normal serum intact PTH levels (21.95–40.15 pg/ mL). Diagnoses: A parathyroid tumor was localized by ultrasonography and 99mTc-sestamibi dual-phase fusion imaging with single-photon emission computed tomography/computed tomography. Interventions: Parathyroidectomy was performed to excise the tumor completely. Outcomes: A 1.2-cm-sized parathyroid adenoma was removed surgically. The serum calcium was declined to normal level immediately after resection, as well as in 4- month follow-ups. The immunohistological diagnosis proved to be a PTH positive parathyroid adenoma. Lessons: In case of hypercalcemia, serum intact PTH and parathyroid imaging should be monitored to evaluate the presence of parathyroid adenoma with care because PHPT could present with inappropriate normal PTH.
- Published
- 2018
9. Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes
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Can Pang, Weiping Jia, Yuqian Bao, Junxi Lu, Chen Wang, and Kun-san Xiang
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medicine.medical_specialty ,business.industry ,Insulin ,medicine.medical_treatment ,Area under the curve ,General Medicine ,Type 2 diabetes ,medicine.disease ,Insulin resistance ,Endocrinology ,Internal medicine ,Diabetes mellitus ,Medicine ,Decompensation ,Beta cell ,business ,Homeostasis - Abstract
Background Type 2 diabetes is a chronic disease characterized by a progressive loss of beta cell functions. However, the evaluation of beta cell functions is either expensive or inconvenient for clinical practice. We aimed to elucidate the association between the changes of insulin responsiveness and the fasting plasma glucose (FPG) during the development of diabetes. Methods A total of 1192 Chinese individuals with normal blood glucose or hyperglycemia were enrolled for the analysis. The early insulinogenic index (DeltaI30/DeltaG30), the area under the curve of insulin (AUC-I), and homeostasis model assessment were applied to evaluate the early phase secretion, total insulin secretion, and insulin resistance respectively. Polynomial regression analysis was performed to estimate the fluctuation of beta cell functions. Results The DeltaI30/DeltaG30 decreased much more rapidly than the AUC-I accompanying with the elevation of FPG. At the FPG of 110 mg/dl (a pre-diabetic stage), the DeltaI30/DeltaG30 lost 50% of its maximum while the AUC-I was still at a compensated normal level. The AUC-I exhibited abnormal and decreased gradually at the FPG of from 130 mg/dl to higher (overt diabetes), while the DeltaI30/DeltaG30 almost remained at 25% of its maximum value. When hyperglycemia continuously existed at > 180 mg/dl, both the DeltaI30/DeltaG30 and AUC-I were totally lost. Conclusion The increased fasting plasma glucose reflects progressive decompensation of beta cell functions, and could be used to guide the strategy of clinical treatments.
- Published
- 2008
10. Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults
- Author
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Jun, Lu, Xuhong, Hou, Can, Pang, Lei, Zhang, Cheng, Hu, Jungong, Zhao, Yuqian, Bao, and Weiping, Jia
- Subjects
Adult ,Male ,China ,Middle Aged ,Prognosis ,Cross-Sectional Studies ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,Humans ,Female ,Latent Autoimmune Diabetes in Adults ,Pancreas ,Aged ,Follow-Up Studies - Abstract
This study aimed to compare pancreatic volume and its clinical significance among patients with type 2 diabetes mellitus (DM), adult-onset type 1 DM and latent autoimmune diabetes in adults (LADA).This is a cross-sectional study. One hundred twenty-six outpatients (68 with LADA and 58 with type 1 DM) and 158 inpatients (71 with type 2 DM and 87 non-diabetic controls) were recruited during May-July 2013 in Shanghai Jiao Tong University Affiliated Sixth People's Hospital. All the patients underwent abdominal computerized tomography; pancreatic volume was then calculated.The mean pancreatic volume was highest in the controls, followed by those in patients with type 2 DM, LADA and type 1 DM. The pancreatic volume in LADA was comparable with that in type 2 DM but significantly greater than that in type 1 DM (p 0.05). The pancreatic volume in patients with LADA was significantly correlated with sex, waist circumference, body surface area, body mass index, diastolic blood pressure and high-density lipoprotein cholesterol (all p 0.05). The correlation between pancreatic volume and fasting C-peptide was high in patients with LADA (r = 0.643, p 0.001) and moderate in patients with type 2 DM (r = 0.467, p 0.001). The area under the receiver operating characteristic curve for pancreatic volume predictive of absolute insulin deficiency (FCP 0.9 ng/mL) was 0.85 (0.76-0.94) in LADA.Pancreatic atrophy in LADA was less marked than in type 1 DM. Pancreatic atrophy may suggest reduced level of fasting C-peptide in patients with LADA. Copyright © 2016 John WileySons, Ltd.
- Published
- 2015
11. Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin: an open-label, randomised, controlled trial
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Lei Chen, Jun Yang, Xinhua Xiao, Fei Gao, Lee-Ming Chuang, Yuqian Bao, Pengfei Li, Qiuhe Ji, Weiping Jia, Yinfang Tu, Can Pang, and Kyu-Jeung Ahn
- Subjects
Male ,medicine.medical_specialty ,China ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Population ,Taiwan ,Insulin Glargine ,Type 2 diabetes ,law.invention ,Endocrinology ,Randomized controlled trial ,law ,Internal medicine ,Diabetes mellitus ,Republic of Korea ,Internal Medicine ,medicine ,Insulin lispro ,Humans ,Hypoglycemic Agents ,education ,Aged ,Glycated Hemoglobin ,education.field_of_study ,Insulin Lispro ,business.industry ,Insulin glargine ,Insulin ,Middle Aged ,medicine.disease ,Hypoglycemia ,Metformin ,Surgery ,Regimen ,Treatment Outcome ,Diabetes Mellitus, Type 2 ,Drug Therapy, Combination ,Female ,Acarbose ,business ,Inositol ,medicine.drug - Abstract
Summary Background Unlike in western countries, premixed insulin is widely used as the starter insulin in Asian patients instead of basal insulin. The use of basal-bolus therapy as an intensification regimen is not common in Asia despite poor glycaemic control after starting insulin therapy. An alternative insulin intensification regimen with a similar efficacy and safety profile to basal-bolus therapy, but of higher convenience, is urgently needed. The efficacy and safety of insulin lispro mix thrice-daily was compared with basal-bolus therapy in Asian patients with type 2 diabetes who were insufficiently controlled on twice-daily premixed insulin. Methods This open-label, randomised, active comparator-controlled, parallel-group trial was done at 24 centres in China, Taiwan, and South Korea. Patients with type 2 diabetes who were inadequately controlled on twice-daily premixed insulin were randomly assigned (1:1) to receive either insulin lispro mix (mix 50 before breakfast and lunch plus mix 25 before dinner) or basal-bolus therapy (insulin glargine at bedtime plus prandial insulin lispro thrice-daily) for 24 weeks. Randomisation was done by a computer-generated random sequence and was stratified by country or region and baseline HbA 1c . Treatment assignments were masked from the study team assessing outcomes but not from investigators and patients. The primary outcome was change from baseline in HbA 1c at week 24 in all randomly assigned patients who received at least one dose of study drug. Analysis was by modified intention to treat, with the per-protocol population used as a supportive analysis. This study is registered with ClinicalTrials.gov, number NCT01175811. Findings Between Feb 7, 2011, and Nov 7, 2012, 402 patients were enrolled (199 in the premix group, 203 in the basal-bolus group) and 399 were included in the primary analysis (197 in the premix group, 202 in the basal-bolus group). HbA 1c change at week 24 was −1·1% for both treatment groups. The least squares mean difference between groups in HbA 1c change from baseline was 0% (95% CI −0·1 to 0·2). Insulin lispro mix was non-inferior to basal-bolus therapy based on the prespecified margin of 0·4%. The frequency of adverse events, and the incidences and 30-day rates of nocturnal and overall hypoglycaemia were comparable between groups. No severe hypoglycaemia was reported. Interpretation A premixed insulin lispro regimen thrice-daily was non-inferior to basal-bolus therapy in terms of overall glycaemic control and thus could be an option for intensified insulin regimen in Asian patients with type 2 diabetes who are inadequately controlled with twice-daily premixed insulin. Funding Eli Lilly and Company.
- Published
- 2015
12. Associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults and type 2 diabetes
- Author
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Jun, Lu, Xuhong, Hou, Lei, Zhang, Cheng, Hu, Jian, Zhou, Can, Pang, Xiaoping, Pan, Yuqian, Bao, and Weiping, Jia
- Subjects
Adult ,Male ,China ,Diabetic Cardiomyopathies ,Middle Aged ,Autoimmune Diseases ,Diabetes Mellitus, Type 2 ,Diabetic Neuropathies ,ROC Curve ,Cardiovascular Diseases ,Risk Factors ,Microvessels ,Diabetes Mellitus ,Disease Progression ,Prevalence ,Humans ,Female ,Registries ,Diabetic Angiopathies ,Aged ,Autoantibodies ,Retrospective Studies - Abstract
This study aimed to assess the associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults (LADA) and type 2 diabetes.This is a retrospective study. Our diabetes registry included 6975 patients aged 30-75 years old with phenotypic type 2 diabetes who underwent islet autoantibody screening between 2003 and 2012; 384 patients were identified to have LADA. Rates of chronic complications for LADA and type 2 diabetes were compared using a 1 : 2 matched design. Logistic models were fitted to identify the presence of chronic diabetic complications using clinical characteristics including gender, age, duration of diabetes, glycemic control and metabolic syndrome.When duration of diabetes is5 years, the prevalence of diabetic nephropathy (nephropathy; 12.2% versus 21.8%, p = 0.018) and diabetic retinopathy (retinopathy; 8.1% versus 15.9%, p = 0.011) were significantly lower in patients with LADA than in patients with type 2 diabetes; the prevalence of nephropathy and retinopathy were comparable between both groups when duration is ≥5 years. There was no significant difference in the prevalence of macrovascular complications between groups. The areas under the receiver operating characteristic curves based on the nephropathy and retinopathy models were larger for LADA than for type 2 diabetes (0.72 versus 0.61, p = 0.013; 0.76 versus 0.68, p = 0.056).Patients with LADA had a lower prevalence of microvascular complications than patients with type 2 diabetes when the duration of diabetes was5 years. Regression equation fitted by clinical characteristics can better predict the risk of microvascular complications in LADA than in type 2 diabetes.
- Published
- 2014
13. Case report: incidental parathyroid adenoma in a Chinese diabetic patient with hypercalcemia and normal parathyroid hormone levels.
- Author
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Can Pang, Youben Fan, Huizheng Zhang, Haoyong Yu, Bomin Guo, Jie Kang, Xianzhao Deng, and Yuqian Bao
- Published
- 2018
- Full Text
- View/download PDF
14. Determination of diabetic retinopathy prevalence and associated risk factors in Chinese diabetic and pre-diabetic subjects: Shanghai diabetic complications study
- Author
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Can, Pang, Lili, Jia, Sunfang, Jiang, Wei, Liu, Xuhong, Hou, Yuhua, Zuo, Huilin, Gu, Yuqian, Bao, Qiang, Wu, Kunsan, Xiang, Xin, Gao, and Weiping, Jia
- Subjects
Adult ,Aged, 80 and over ,Blood Glucose ,Glycated Hemoglobin ,Male ,China ,Diabetic Retinopathy ,Adolescent ,Middle Aged ,Diabetes Complications ,Prediabetic State ,Asian People ,Risk Factors ,Hyperglycemia ,Glucose Intolerance ,Hypertension ,Prevalence ,Albuminuria ,Humans ,Female ,Obesity ,Aged - Abstract
The prevalence of diabetic retinopathy is not well studied in the Chinese pre-diabetic population, also known as impaired glucose regulation. Hence, we investigated the prevalence of and risk factors associated with retinopathy in diabetic and pre-diabetic subjects from Chinese communities.A total of 3736 Chinese subjects were recruited from urban communities in Shanghai. The participants were classified as normal glucose tolerance, impaired glucose regulation (IGR) and diabetes based on the 75 g oral glucose tolerance test. The levels of diabetic retinopathy (DR) were assessed with non-mydriatic retinal photographs according to the Diabetic Retinopathy Disease Severity Scale.The prevalence of diabetic retinopathy in patients with diabetes and impaired glucose regulation subjects was 9.4% and 2.5%, respectively. In subjects with IGR, hypertension (odds ratio: 3.54, p = 0.028), including elevated systolic and diastolic blood pressure and obesity (odds ratio: 3.53, p = 0.028) were significantly associated with diabetic retinopathy after age and sex adjustments. The factors associated with retinopathy in diabetes included diabetes duration, blood glucose levels, glycated hemoglobin levels, and the presence of albuminuria. Diabetic retinopathy was significantly associated with fasting plasma glucose in known diabetes, whereas in newly-diagnosed subjects, diabetic neuropathy was closely correlated to postprandial plasma glucose.Hyperglycemia was a strong risk factor for diabetic retinopathy. In pre-diabetic subjects, diabetic retinopathy was also associated with hypertension and obesity.
- Published
- 2011
15. Prevalence and risk factors of albuminuria and chronic kidney disease in Chinese population with type 2 diabetes and impaired glucose regulation: Shanghai diabetic complications study (SHDCS)
- Author
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Yuqian Bao, Weiping Jia, Xuhong Hou, Kun-san Xiang, Wen-xia Wang, Xin Gao, Yuhua Zuo, Wei Liu, Hui-Lin Gu, and Can Pang
- Subjects
Male ,medicine.medical_specialty ,China ,Renal function ,Type 2 diabetes ,urologic and male genital diseases ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Prevalence ,Medicine ,Albuminuria ,Humans ,Diabetic Nephropathies ,Risk factor ,Aged ,Transplantation ,business.industry ,Urban Health ,Odds ratio ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Endocrinology ,Glucose ,Diabetes Mellitus, Type 2 ,Nephrology ,Chronic Disease ,Microalbuminuria ,Female ,Kidney Diseases ,medicine.symptom ,business ,Kidney disease - Abstract
Background. Diabetes is a major risk factor for the development of kidney disease. We aimed to determine the prevalence of albuminuria and chronic kidney disease (CKD) in Chinese subjects with diabetes and pre-diabetes and the risk factors for kidney disease. Methods. An urban community-based sample of 3714 adults in Shanghai was classified into normal glucose tolerance (NGT), impaired glucose regulation (IGR) and diabetes. The estimated glomerular filtration rate (eGFR) and the urinary albumin-to-creatinine ratio (ACR) were applied to designate renal function and albuminuria, respectively. Binary logistic regression was performed to analyse the contribution of risk factors to CKD. Polynominal regression was used to determine the trends of eGFR with the increment of ACR. Results. The prevalence of microalbuminuria, macroalbuminuria and CKD in subjects with diabetes was 22.8%, 3.4% and 29.6%, respectively, which was significantly higher than that in non-diabetes subjects. After adjustment for age, the odds ratio of hypertension for albuminuria and renal insufficiency (eGFR
- Published
- 2009
16. Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity
- Author
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Can Pang, Jin Zhang, Jianping Ye, Weiping Jia, Zhanguo Gao, and Jun Yin
- Subjects
CD31 ,Male ,medicine.medical_specialty ,Platelet-derived growth factor ,Physiology ,Angiogenesis ,Cell Survival ,Endocrinology, Diabetes and Metabolism ,Adipose tissue macrophages ,medicine.medical_treatment ,Adipose tissue ,Mice, Obese ,chemistry.chemical_compound ,Mice ,Phosphatidylinositol 3-Kinases ,Physiology (medical) ,Internal medicine ,3T3-L1 Cells ,medicine ,Animals ,Obesity ,RNA, Messenger ,Hypoxia ,Tube formation ,Platelet-Derived Growth Factor ,biology ,Neovascularization, Pathologic ,Reverse Transcriptase Polymerase Chain Reaction ,Growth factor ,Macrophages ,Ribosomal Protein S6 Kinases ,TOR Serine-Threonine Kinases ,Articles ,Antigens, Differentiation ,Immunohistochemistry ,Mice, Inbred C57BL ,Oncogene Protein v-akt ,Platelet Endothelial Cell Adhesion Molecule-1 ,Endocrinology ,chemistry ,Adipose Tissue ,biology.protein ,Protein Kinases ,Platelet-derived growth factor receptor - Abstract
The biological role of macrophage infiltration into adipose tissue in obesity remains to be fully understood. We hypothesize that macrophages may act to stimulate angiogenesis in the adipose tissue. This possibility was examined by determining macrophage expression of angiogenic factor PDGF (platelet-derived growth factor) and regulation of tube formation of endothelial cells by PDGF. The data suggest that endothelial cell density was reduced in the adipose tissue of ob/ob mice. Expression of endothelial marker CD31 was decreased in protein and mRNA. The reduction was associated with an increase in macrophage infiltration. In the obese mice, PDGF concentration was elevated in the plasma, and its mRNA expression was increased in adipose tissue. Macrophages were found to be a major source of PDGF in adipose tissue, as deletion of macrophages led to a significant reduction in PDGF mRNA. In cell culture, PDGF expression was induced by hypoxia, and tube formation of endothelial cells was induced by PDGF. The PDGF activity was dependent on S6K, as inhibition of S6K in endothelial cells led to inhibition of the PDGF activity. We conclude that, in response to the reduced vascular density, macrophages may express PDGF in adipose tissue to facilitate capillary formation in obesity. Although the PDGF level is elevated in adipose tissue, its activity in angiogenesis is dependent on the availability of sufficient endothelial cells. The study suggests a new function of macrophages in the adipose tissue in obesity.
- Published
- 2008
17. Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities
- Author
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Huijuan Lu, Wei Jia, Y. H. Zuo, Junling Tang, Can Pang, Liwei Chen, Y. M. Wu, Jingyi Lu, Yuqian Bao, Kun-san Xiang, and S. Y. Jiang
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,Urban Population ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Population ,Overweight ,Internal medicine ,Diabetes mellitus ,Epidemiology ,Glucose Intolerance ,Internal Medicine ,medicine ,Diabetes Mellitus ,Prevalence ,Humans ,Cumulative incidence ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Middle Aged ,medicine.disease ,Endocrinology ,Cross-Sectional Studies ,Relative risk ,Female ,medicine.symptom ,business ,Demography ,Follow-Up Studies - Abstract
To estimate the prevalence and incidence of diabetes mellitus and impaired glucose regulation (IGR) in a Chinese population aged 20–94 years. A group of 5,628 randomly selected adults, aged 20–94 years, living in the Huayang and Caoyang communities in Shanghai, China, were investigated between 1998 and 2001. During 2002-04, 2,666 subjects were followed up. All the participants underwent anthropometric measurements, blood biochemical analyses and a 75-g OGTT. Based on the 2000 census data of China, the age-standardised prevalences were 6.87% for diabetes and 8.53% for IGR at baseline. More than two in five cases with diabetes were undiagnosed. The age-adjusted prevalence of diabetes and IGR increased with age. The age-adjusted prevalences of hypertension, dyslipidaemia and overweight in males were significantly higher (p
- Published
- 2006
18. The Significance of Screening for Microvascular Diseases in Chinese Community-Based Subjects with Various Metabolic Abnormalities
- Author
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Wei-Wei Liu, Xin Gao, Lili Jia, Xuhong Hou, Can Pang, Weiping Jia, and Yuqian Bao
- Subjects
Male ,Urban Population ,Epidemiology ,lcsh:Medicine ,Biochemistry ,Disease Informatics ,Endocrinology ,Medicine and Health Sciences ,Community Health Services ,lcsh:Science ,Metabolic Syndrome ,Multidisciplinary ,Diabetic retinopathy ,Middle Aged ,Type 2 Diabetes ,Research Design ,Observational Studies ,Female ,Metabolic Pathways ,medicine.symptom ,Research Article ,Retinopathy ,China ,medicine.medical_specialty ,Clinical Research Design ,Hypertensive Retinopathy ,Research and Analysis Methods ,Hypertensive retinopathy ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,medicine ,Albuminuria ,Humans ,Vascular Diseases ,Risk factor ,National Cholesterol Education Program ,Aged ,Retrospective Studies ,Diabetic Endocrinology ,business.industry ,lcsh:R ,Biology and Life Sciences ,medicine.disease ,Metabolism ,Cross-Sectional Studies ,Metabolic Disorders ,lcsh:Q ,Metabolic syndrome ,business - Abstract
BACKGROUND: To assess the association of albuminuria and retinopathy with metabolic syndrome (MetS) and the related metabolic components defined by various criteria in Chinese community-based subjects. METHODS: A total of 3240 Chinese subjects were recruited from urban communities and classified into subgroups with isolated or concomitant state of the two microvascular diseases. MetS was defined according to the standard of International Diabetes Federation, the National Cholesterol Education Program's Adult Treatment Panel III and Chinese Diabetes Society (CDS), separately. Albuminuria was defined as an elevated morning urine albumin-to-creatinine ratio. Retinopathy were identified with nonmydriatic retinal photographs according to the Diabetic Retinopathy Disease Severity Scale. Logistic regression was performed to analyze the contributive risk factors. RESULTS: The subgroup of isolated retinopathy was the oldest (P
- Published
- 2014
19. CPVL/CHN2 Genetic Variant Is Associated With Diabetic Retinopathy in Chinese Type 2 Diabetic Patients.
- Author
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Cheng Hu, Rong Zhang, Weihui Yu, Jie Wang, Congrong Wang, Can Pang, Xiaojing Ma, Yuqian Bao, Kunsan Xiang, and Weiping Jia
- Subjects
DIABETES complications ,DIABETIC retinopathy ,GENOMES ,GENETIC polymorphisms ,RETINAL diseases - Abstract
OBJECTIVE--Diabetic nephropathy and retinopathy are two important microvascular diabetes complications with a high concordance rate in diabetic patients. A recent genome-wide association study in type 1 diabetic patients of European descent identified four loci to be associated with diabetic nephropathy. The aim of this study was to test the effects of single nucleotide polymorphisms (SNPs) from these four loci on diabetic nephropathy and retinopathy in Chinese type 2 diabetic patients. RESEARCH DESIGN AND METHODS--In stage 1, we recruited 1,276 type 2 diabetic patients, including 378 patients with diabetic nephropathy but no retinopathy, 374 patients with diabetic retinopathy but no nephropathy, 244 patients with both diabetic retinopathy and nephropathy, and 280 control subjects with diabetes for >10 years and no diabetic retinopathy or nephropathy. Fifty-five SNPs from four loci (CPVL/CHN2, FRMD3, CARS, and IRS2) were genotyped. The SNPs that showed associations to diabetic retinopathy or nephropathy were genotyped in stage 2 samples for replication. RESULTS--SNPs from CPVL/CHN2 and FRMD3 were associated with diabetic retinopathy with rs39059 and rs10868025 as the top SNPs (odds ratio [OR] 1.292, 95% CI 1.097--1.523, P = 0.0022, for rs39059; 1.201, 1.014--1.422, P = 0.0343, for rs10868025) in stage 1 samples. In stage 2 analysis, only rs39059 showed similar effect to diabetic retinopathy (OR 1.269, 0.989--1.628, P = 0.0689), and meta-analysis showed a significant association between rs39059 and diabetic retinopathy, with an OR of 1.285 (1.120--1.474, P = 0.0003). CPVL/CHN2 rs39059 was also associated with levels of diabetic retinopathy (P = 0.0007 for trend). However, no association was detected between these SNPs and diabetic nephropathy. CONCLUSIONS--In this study, we found CPVL/CHN2 rs39059 was associated with diabetic retinopathy in the Chinese type 2 diabetic patients. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
20. Prevalence and risk factors of albuminuria and chronic kidney disease in Chinese population with type 2 diabetes and impaired glucose regulation: Shanghai diabetic complications study (SHDCS).
- Author
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Weiping Jia, Xin Gao, Can Pang, Xuhong Hou, Yuqian Bao, Wei Liu, Wenxia Wang, Yuhua Zuo, Huilin Gu, and Kunsan Xiang
- Subjects
ALBUMINURIA ,CHRONIC kidney failure ,PEOPLE with diabetes ,KIDNEY disease risk factors ,DISEASE complications ,PATIENTS ,DISEASE risk factors - Abstract
Background. Diabetes is a major risk factor for the development of kidney disease. We aimed to determine the prevalence of albuminuria and chronic kidney disease (CKD) in Chinese subjects with diabetes and pre-diabetes and the risk factors for kidney disease. [ABSTRACT FROM PUBLISHER]
- Published
- 2009
- Full Text
- View/download PDF
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