13 results on '"Campos-Herrero, Isolina"'
Search Results
2. Multidrug-resistant Mycobacterium tuberculosis strain from equatorial guinea detected in Spain
- Author
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Gavin, Patricia, Iglesias, Maria J., Jimenez, Maria S., Herrera-Leon, Laura, Rodriguez-Valin, Elena, Rastogi, Nalin, March, Josefa, Gonzalez-Palacios, Rosa, Palenque, Elia, Ayarza, Rafael, Hurra, Elena, Campos-Herrero, Isolina, Vitoria, Maria A., Lezcano, Maria A., Revillo, Maria J., Martin, Carlos, and Samper, Sofia
- Subjects
Drug resistance in microorganisms -- Health aspects ,Drug resistance in microorganisms -- Research ,Mycobacterium tuberculosis -- Identification and classification ,Mycobacterium tuberculosis -- Health aspects ,Mycobacterium tuberculosis -- Genetic aspects ,Mycobacterium tuberculosis -- Research ,Prevalence studies (Epidemiology) -- Usage ,Prevalence studies (Epidemiology) -- Methods - Abstract
To the Editor: Eleven years of molecular epidemiologic data allowed the Spanish Multidrug-resistant Tuberculosis (MDR TB) Surveillance Network to identify a specific MDR Mycobacterium tuberculosis strain that had been imported [...]
- Published
- 2009
- Full Text
- View/download PDF
3. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
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Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael G.B., Rüsch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Béguec, Caroline, Antierens, Annick, Augustynowicz-Kopeć, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Barry, Clifton E., Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebæk, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Branislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, Vukovic, Dragana, Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael G.B., Rüsch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Béguec, Caroline, Antierens, Annick, Augustynowicz-Kopeć, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Barry, Clifton E., Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebæk, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Branislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, and Vukovic, Dragana
- Abstract
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
- Published
- 2015
4. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
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Merker, Matthias, primary, Blin, Camille, additional, Mona, Stefano, additional, Duforet-Frebourg, Nicolas, additional, Lecher, Sophie, additional, Willery, Eve, additional, Blum, Michael G B, additional, Rüsch-Gerdes, Sabine, additional, Mokrousov, Igor, additional, Aleksic, Eman, additional, Allix-Béguec, Caroline, additional, Antierens, Annick, additional, Augustynowicz-Kopeć, Ewa, additional, Ballif, Marie, additional, Barletta, Francesca, additional, Beck, Hans Peter, additional, Barry, Clifton E, additional, Bonnet, Maryline, additional, Borroni, Emanuele, additional, Campos-Herrero, Isolina, additional, Cirillo, Daniela, additional, Cox, Helen, additional, Crowe, Suzanne, additional, Crudu, Valeriu, additional, Diel, Roland, additional, Drobniewski, Francis, additional, Fauville-Dufaux, Maryse, additional, Gagneux, Sébastien, additional, Ghebremichael, Solomon, additional, Hanekom, Madeleine, additional, Hoffner, Sven, additional, Jiao, Wei-wei, additional, Kalon, Stobdan, additional, Kohl, Thomas A, additional, Kontsevaya, Irina, additional, Lillebæk, Troels, additional, Maeda, Shinji, additional, Nikolayevskyy, Vladyslav, additional, Rasmussen, Michael, additional, Rastogi, Nalin, additional, Samper, Sofia, additional, Sanchez-Padilla, Elisabeth, additional, Savic, Branislava, additional, Shamputa, Isdore Chola, additional, Shen, Adong, additional, Sng, Li-Hwei, additional, Stakenas, Petras, additional, Toit, Kadri, additional, Varaine, Francis, additional, Vukovic, Dragana, additional, Wahl, Céline, additional, Warren, Robin, additional, Supply, Philip, additional, Niemann, Stefan, additional, and Wirth, Thierry, additional
- Published
- 2015
- Full Text
- View/download PDF
5. Proposal of a Consensus Set of Hypervariable Mycobacterial Interspersed Repetitive-Unit–Variable-Number Tandem-Repeat Loci for Subtyping of Mycobacterium tuberculosis Beijing Isolates
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Allix-Béguec, Caroline, primary, Wahl, Céline, additional, Hanekom, Madeleine, additional, Nikolayevskyy, Vladyslav, additional, Drobniewski, Francis, additional, Maeda, Shinji, additional, Campos-Herrero, Isolina, additional, Mokrousov, Igor, additional, Niemann, Stefan, additional, Kontsevaya, Irina, additional, Rastogi, Nalin, additional, Samper, Sofia, additional, Sng, Li-Hwei, additional, Warren, Robin M., additional, and Supply, Philip, additional
- Published
- 2014
- Full Text
- View/download PDF
6. Multidrug-ResistantMycobacterium tuberculosisStrain from Equatorial Guinea Detected in Spain
- Author
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Gavín, Patricia, primary, Iglesias, María J., additional, Jiménez, María S., additional, Herrera-León, Laura, additional, Rodríguez-Valín, Elena, additional, Rastogi, Nalin, additional, March, Josefa, additional, González-Palacios, Rosa, additional, Palenque, Elia, additional, Ayarza, Rafael, additional, Hurra, Elena, additional, Campos-Herrero, Isolina, additional, Vitoria, María A., additional, Lezcano, María A., additional, Revillo, María J., additional, Martín, Carlos, additional, and Samper, Sofía, additional
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- 2009
- Full Text
- View/download PDF
7. Proposal of a Consensus Set of Hypervariable Mycobacterial Interspersed Repetitive-Unit–Variable-Number Tandem-Repeat Loci for Subtyping of Mycobacterium tuberculosisBeijing Isolates
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Allix-Béguec, Caroline, Wahl, Céline, Hanekom, Madeleine, Nikolayevskyy, Vladyslav, Drobniewski, Francis, Maeda, Shinji, Campos-Herrero, Isolina, Mokrousov, Igor, Niemann, Stefan, Kontsevaya, Irina, Rastogi, Nalin, Samper, Sofia, Sng, Li-Hwei, Warren, Robin M., and Supply, Philip
- Abstract
ABSTRACTMycobacterium tuberculosisBeijing strains represent targets of special importance for molecular surveillance of tuberculosis (TB), especially because they are associated with spread of multidrug resistance in some world regions. Standard 24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing lacks resolution power for accurately discriminating closely related clones that often compose Beijing strain populations. Therefore, we evaluated a set of 7 additional, hypervariable MIRU-VNTR loci for better resolution and tracing of such strains, using a collection of 535 Beijing isolates from six world regions where these strains are known to be prevalent. The typeability and interlaboratory reproducibility of these hypervariable loci were lower than those of the 24 standard loci. Three loci (2163a, 3155, and 3336) were excluded because of their redundant variability and/or more frequent noninterpretable results compared to the 4 other markers. The use of the remaining 4-locus set (1982, 3232, 3820, and 4120) increased the number of types by 52% (from 223 to 340) and reduced the clustering rate from 58.3 to 36.6%, when combined with the use of the standard 24-locus set. Known major clonal complexes/24-locus-based clusters were all subdivided, although the degree of subdivision varied depending on the complex. Only five single-locus variations were detected among the hypervariable loci of an additional panel of 92 isolates, representing 15 years of clonal spread of a single Beijing strain in a geographically restricted setting. On this calibrated basis, we propose this 4-locus set as a consensus for subtyping Beijing clonal complexes and clusters, after standard typing.
- Published
- 2014
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- View/download PDF
8. Epidemiological Cutoff Values for Fluconazole, Itraconazole, Posaconazole, and Voriconazole for Six CandidaSpecies as Determined by the Colorimetric Sensititre YeastOne Method
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Cantón, Emilia, Pemán, Javier, Iñiguez, Carmen, Hervás, David, Lopez-Hontangas, Jose L., Pina-Vaz, Cidalia, Camarena, Juan J., Campos-Herrero, Isolina, García-García, Inmaculada, García-Tapia, Ana M., Guna, Remedios, Merino, Paloma, Pérez del Molino, Luisa, Rubio, Carmen, and Suárez, Anabel
- Abstract
ABSTRACTIn the absence of clinical breakpoints (CBP), epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of susceptibility tests. Sensititre YeastOne (SYO) is a widely used method to determine susceptibility of Candidaspp. to antifungal agents. The CLSI CBP have been established, but not for the SYO method. The ECVs for four azoles, obtained using MIC distributions determined by the SYO method, were calculated via five methods (three statistical methods and based on the MIC50and modal MIC). Respectively, the median ECVs (in mg/liter) of the five methods for fluconazole, itraconazole, posaconazole, and voriconazole (in parentheses: the percentage of isolates inhibited by MICs equal to or less than the ECVs; the number of isolates tested) were as follows: 2 (94.4%; 944), 0.5 (96.7%; 942), 0.25 (97.6%; 673), and 0.06 (96.7%; 849) for Candida albicans; 4 (86.1%; 642), 0.5 (99.4%; 642), 0.12 (93.9%; 392), and 0.06 (86.9%; 559) for C. parapsilosis; 8 (94.9%; 175), 1 (93.7%; 175), 2 (93.6%; 125), and 0.25 (90.4%; 167) for C. tropicalis; 128 (98.6%; 212), 4 (95.8%; 212), 4 (96.0%; 173), and 2 (98.5; 205) for C. glabrata; 256 (100%; 53), 1 (98.1%; 53), 1 (100%; 33), and 1 (97.9%; 48) for C. krusei; 4 (89.2%; 93), 0.5 (100%; 93), 0.25 (100%; 33), and 0.06 (87.7%; 73) for C. orthopsilosis. All methods included =94% of isolates and yielded similar ECVs (within 1 dilution). These ECVs would be suitable for monitoring emergence of isolates with reduced susceptibility by using the SYO method.
- Published
- 2013
- Full Text
- View/download PDF
9. Prospective Multicenter Study of the Epidemiology, Molecular Identification, and Antifungal Susceptibility of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosisIsolated from Patients with Candidemia
- Author
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Cantón, Emilia, Pemán, Javier, Quindós, Guillermo, Eraso, Elena, Miranda-Zapico, Ilargi, Álvarez, María, Merino, Paloma, Campos-Herrero, Isolina, Marco, Francesc, de la Pedrosa, Elia Gomez G., Yagüe, Genoveva, Guna, Remedios, Rubio, Carmen, Miranda, Consuelo, Pazos, Carmen, and Velasco, David
- Abstract
ABSTRACTA 13-month prospective multicenter study including 44 hospitals was carried out to evaluate the epidemiology of Candida parapsilosiscomplex candidemia in Spain. Susceptibility to amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, caspofungin, and micafungin was tested by the microdilution colorimetric method. A total of 364 C. parapsilosiscomplex isolates were identified by molecular methods: C. parapsilosis(90.7%), Candida orthopsilosis(8.2%), and Candida metapsilosis(1.1%). Most candidemias (C. parapsilosis, 76.4%; C. orthopsilosis, 70.0%; C. metapsilosis, 100%) were observed in adults. No C. orthopsilosisor C. metapsilosiscandidemias occurred in neonates. C. parapsilosiswas most frequent in adult intensive care unit (28.8%), surgery (20.9%), and internal medicine (19.7%) departments; and C. orthopsilosiswas most frequent in hematology (28.6%), pediatrics (12.0%), and neonatology (11.5%) departments. The geographic distribution of C. orthopsilosisand C. metapsilosiswas not uniform. According to CLSI clinical breakpoints, all C. orthopsilosisand C. metapsilosisisolates were susceptible to the nine agents tested. Resistance (MICs > 1 mg/liter) was observed only in C. parapsilosis: amphotericin B, posaconazole, itraconazole, and caspofungin (0.3% each), anidulafungin (1.9%), and micafungin (2.5%). Applying the new species-specific fluconazole and echinocandin breakpoints, the rates of resistance to fluconazole for C. parapsilosisand C. orthopsilosisincreased to 4.8% and 0.3%, respectively; conversely, for C. parapsilosisthey shifted from 1.9 to 0.6% (anidulafungin) and from 2.5 to 0.6% (micafungin). Our study confirms the different prevalence of C. parapsilosiscomplex candidemia among age groups: neither C. orthopsilosisnor C. metapsilosiswas isolated from neonates; interestingly, C. metapsilosiswas isolated only from adults and the elderly. The disparity in antifungal susceptibility among species could be important for therapy.
- Published
- 2011
- Full Text
- View/download PDF
10. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage (vol 47, pg 242, 2015)
- Author
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Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael, Ruesch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Beguec, Caroline, Antierens, Annick, Augustynowicz-Kopec, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Clifton E Barry, Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sebastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei-Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebeak, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Ranislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li-Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, Vukovic, Dragana, Wahl, Celine, Warren, Robin, Supply, Philip, Niemann, Stefan, and Wirth, Thierry
11. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
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Blum, Michael G B, Blin, Camille, Drobniewski, Francis, Wirth, Thierry, Stakenas, Petras, Allix-Béguec, Caroline, Barletta, Francesca, Sanchez-Padilla, Elisabeth, Warren, Robin, Vukovic, Dragana, Toit, Kadri, Augustynowicz-Kopeć, Ewa, Borroni, Emanuele, Varaine, Francis, Barry, Clifton E, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Mokrousov, Igor, Cox, Helen, Samper, Sofia, Duforet-Frebourg, Nicolas, Kohl, Thomas A, Maeda, Shinji, Bonnet, Maryline, Aleksic, Eman, Wahl, Céline, Hanekom, Madeleine, Rüsch-Gerdes, Sabine, Hoffner, Sven, Campos-Herrero, Isolina, Ballif, Marie, Jiao, Wei-Wei, Crowe, Suzanne, Rastogi, Nalin, Ghebremichael, Solomon, Lillebæk, Troels, Sng, Li-Hwei, Cirillo, Daniela, Kalon, Stobdan, Kontsevaya, Irina, Antierens, Annick, Rasmussen, Michael, Nikolayevskyy, Vladyslav, Supply, Philip, Crudu, Valeriu, Diel, Roland, Savic, Branislava, Merker, Matthias, Niemann, Stefan, Beck, Hans Peter, Lecher, Sophie, Shen, Adong, Shamputa, Isdore Chola, Willery, Eve, and Mona, Stefano
- Subjects
610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
12. Epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole for six Candida species as determined by the colorimetric Sensititre YeastOne method.
- Author
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Cantón E, Pemán J, Iñiguez C, Hervás D, Lopez-Hontangas JL, Pina-Vaz C, Camarena JJ, Campos-Herrero I, García-García I, García-Tapia AM, Guna R, Merino P, Pérez del Molino L, Rubio C, and Suárez A
- Subjects
- Candida isolation & purification, Humans, Microbial Sensitivity Tests, Antifungal Agents pharmacology, Azoles pharmacology, Candida drug effects, Candidiasis microbiology
- Abstract
In the absence of clinical breakpoints (CBP), epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of susceptibility tests. Sensititre YeastOne (SYO) is a widely used method to determine susceptibility of Candida spp. to antifungal agents. The CLSI CBP have been established, but not for the SYO method. The ECVs for four azoles, obtained using MIC distributions determined by the SYO method, were calculated via five methods (three statistical methods and based on the MIC50 and modal MIC). Respectively, the median ECVs (in mg/liter) of the five methods for fluconazole, itraconazole, posaconazole, and voriconazole (in parentheses: the percentage of isolates inhibited by MICs equal to or less than the ECVs; the number of isolates tested) were as follows: 2 (94.4%; 944), 0.5 (96.7%; 942), 0.25 (97.6%; 673), and 0.06 (96.7%; 849) for Candida albicans; 4 (86.1%; 642), 0.5 (99.4%; 642), 0.12 (93.9%; 392), and 0.06 (86.9%; 559) for C. parapsilosis; 8 (94.9%; 175), 1 (93.7%; 175), 2 (93.6%; 125), and 0.25 (90.4%; 167) for C. tropicalis; 128 (98.6%; 212), 4 (95.8%; 212), 4 (96.0%; 173), and 2 (98.5; 205) for C. glabrata; 256 (100%; 53), 1 (98.1%; 53), 1 (100%; 33), and 1 (97.9%; 48) for C. krusei; 4 (89.2%; 93), 0.5 (100%; 93), 0.25 (100%; 33), and 0.06 (87.7%; 73) for C. orthopsilosis. All methods included ≥94% of isolates and yielded similar ECVs (within 1 dilution). These ECVs would be suitable for monitoring emergence of isolates with reduced susceptibility by using the SYO method.
- Published
- 2013
- Full Text
- View/download PDF
13. Prospective multicenter study of the epidemiology, molecular identification, and antifungal susceptibility of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis isolated from patients with candidemia.
- Author
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Cantón E, Pemán J, Quindós G, Eraso E, Miranda-Zapico I, Álvarez M, Merino P, Campos-Herrero I, Marco F, de la Pedrosa EG, Yagüe G, Guna R, Rubio C, Miranda C, Pazos C, and Velasco D
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Antifungal Agents classification, Candida classification, Candida isolation & purification, Candidiasis microbiology, Child, Child, Preschool, Drug Resistance, Fungal, Female, Humans, Infant, Infant, Newborn, Male, Microbial Sensitivity Tests, Middle Aged, Prevalence, Prospective Studies, Spain epidemiology, Species Specificity, Young Adult, Antifungal Agents pharmacology, Candida drug effects, Candida genetics, Candidemia epidemiology, Candidemia microbiology, Candidiasis epidemiology
- Abstract
A 13-month prospective multicenter study including 44 hospitals was carried out to evaluate the epidemiology of Candida parapsilosis complex candidemia in Spain. Susceptibility to amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, caspofungin, and micafungin was tested by the microdilution colorimetric method. A total of 364 C. parapsilosis complex isolates were identified by molecular methods: C. parapsilosis (90.7%), Candida orthopsilosis (8.2%), and Candida metapsilosis (1.1%). Most candidemias (C. parapsilosis, 76.4%; C. orthopsilosis, 70.0%; C. metapsilosis, 100%) were observed in adults. No C. orthopsilosis or C. metapsilosis candidemias occurred in neonates. C. parapsilosis was most frequent in adult intensive care unit (28.8%), surgery (20.9%), and internal medicine (19.7%) departments; and C. orthopsilosis was most frequent in hematology (28.6%), pediatrics (12.0%), and neonatology (11.5%) departments. The geographic distribution of C. orthopsilosis and C. metapsilosis was not uniform. According to CLSI clinical breakpoints, all C. orthopsilosis and C. metapsilosis isolates were susceptible to the nine agents tested. Resistance (MICs > 1 mg/liter) was observed only in C. parapsilosis: amphotericin B, posaconazole, itraconazole, and caspofungin (0.3% each), anidulafungin (1.9%), and micafungin (2.5%). Applying the new species-specific fluconazole and echinocandin breakpoints, the rates of resistance to fluconazole for C. parapsilosis and C. orthopsilosis increased to 4.8% and 0.3%, respectively; conversely, for C. parapsilosis they shifted from 1.9 to 0.6% (anidulafungin) and from 2.5 to 0.6% (micafungin). Our study confirms the different prevalence of C. parapsilosis complex candidemia among age groups: neither C. orthopsilosis nor C. metapsilosis was isolated from neonates; interestingly, C. metapsilosis was isolated only from adults and the elderly. The disparity in antifungal susceptibility among species could be important for therapy.
- Published
- 2011
- Full Text
- View/download PDF
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