Search

Your search keyword '"Campo, Salvatore"' showing total 723 results
Start Over Author "Campo, Salvatore"
723 results on '"Campo, Salvatore"'

40. Catalytic Nanomedicine. Cu/TiO2–SiO2 Nanoparticles as Treatment of Diabetic Foot Ulcer: A Case Report

Author

Junqueira Virginia Berlanga Campos, Rahimi Nahid, Hashemi Mohammad, Alejandro Velázquez-Muñoz Javier, Liu Hui-Hui, M. Campo Giuseppe, Bahari Gholamreza, You Shou-jiang, Li Tianzhong, Murad Neif, D`Ascola Angela, López-Goerne Tessy, Mehdi Hashemi Seyed, Bacci Marcelo Rodrigues, Mandraffino Giuseppe, Reyes-González Jesús, Jin Xu, Azizi Mahsa, Qu Xinyuan, Chauhan Ritika, Zhang Chunyuan, Li Zheng, Yilin Guo, Saitta Antonino, Zatta Simone Meneghetti, Madhumalini M., Zhang Liping, Sun Hexu, Chauhan Vinita, Shi Jijun, Du Lei, Feder David, Cao Yong-jun, Avenoso Angela, Armando Pérez-Dávalos Luis, Kumar Dhaked Ram, Rocha Roberto Odebrecht, Sonkar Priyanka, Devi T. Meera, Fonseca Fernando Luiz Affonso, Adami Fernando, Alves Beatriz da Costa Aguiar, Yang Mengsu, Campo Salvatore, Ramírez-Olivares Paola, Bruschetta Giuseppe, Dong Weichao, Azzalis Ligia Ajaime, Chagas Antonio Carlos Palandri, and Scuruchi Michele

Subjects
Chemistry, Biomedical Engineering, Medicine (miscellaneous), Nanoparticle, Bioengineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, medicine.disease, 030226 pharmacology & pharmacy, Catalysis, 03 medical and health sciences, 0302 clinical medicine, Diabetic foot ulcer, medicine, Nanomedicine, 0210 nano-technology, Nuclear chemistry
Abstract

Introduction: Diabetes mellitus is one of the most important health issues worldwide. The rising incidence of the disease has resulted in a parallel increase of complications such as diabetic foot ulcers (DFU). It is estimated that 25% of patients with diabetes will develop foot ulcers over a lifetime. In Mexico, this lifetime incidence is about 40% to 50%, and 20% of the cases will require amputations. DFU can result in staggering financial burdens for the healthcare system and the patient. Therapies that promote rapid and complete healing and reduce the need for expensive surgical procedures would impact these costs substantially. Methods: Cu/TiO2–SiO2 nanoparticles were synthesized by T. López et al. sol-gel patented method. After synthesis, they were characterized using transmission electron microscopy (TEM) and X-ray diffraction. Then, they were embedded in a polymeric gel matrix. The Cu/TiO2–SiO2 nanogel was used as conservative therapy for a chronic non-healing DFU on a 62-year old female with several comorbidities and chronic complications of diabetes. Wound debridement was performed prior to nanogel administration. The nanogel was applied over the ulcer on alternate days for an initial period of 2 weeks and then continued for 10 months. Results: Significant improvement was observed in the wound healing process since the first applications. The infection was limited and tissue regeneration was enhanced until complete healing of the ulcer. Conclusion: Cu/TiO2–SiO2 nanogel therapy enhanced reepithelialization and healing of the DFU. The successful outcome allowed to avoid the amputation that was proposed for the patient.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results