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6. Local Allergic Rhinitis

Author

Rondón, Carmen, Eguiluz-Gracia, Ibon, Bogas, Gador, Barrionuevo, Esther, Salas, María, Torres, Maria J., Campo, Paloma, and Bernstein, Jonathan A., editor

Published
2018
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9. Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Author

Hox, Valerie, Lourijsen, Evelijn, Jordens, Arnout, Aasbjerg, Kristian, Agache, Ioana, Alobid, Isam, Bachert, Claus, Boussery, Koen, Campo, Paloma, Fokkens, Wytske, Hellings, Peter, Hopkins, Claire, Klimek, Ludger, Mäkelä, Mika, Mösges, Ralph, Mullol, Joaquim, Pujols, Laura, Rondon, Carmen, Rudenko, Michael, Toppila-Salmi, Sanna, Scadding, Glenis, Scheire, Sophie, Tomazic, Peter-Valentin, Van Zele, Thibaut, Wagenmann, Martin, van Boven, Job F. M., and Gevaert, Philippe

Published
2020
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10. Correction to: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Author

Hox, Valerie, Lourijsen, Evelijn, Jordens, Arnout, Aasbjerg, Kristian, Agache, Ioana, Alobid, Isam, Bachert, Claus, Boussery, Koen, Campo, Paloma, Fokkens, Wytske, Hellings, Peter, Hopkins, Claire, Klimek, Ludger, Mäkelä, Mika, Mösges, Ralph, Mullol, Joaquim, Pujols, Laura, Rondon, Carmen, Rudenko, Michael, Toppila-Salmi, Sanna, Scadding, Glenis, Scheire, Sophie, Tomazic, Peter-Valentin, Van Zele, Thibaut, Wagenmann, Martin, van Boven, Job F. M., and Gevaert, Philippe

Published
2020
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11. "Nasal Allergen Challenge (NAC): Practical Aspects and Applications from an EU/US perspective: A Workgroup Report of the AAAAI Rhinitis, Rhinosinusitis and Ocular Allergy Committee"

Author

Cho, Seong H, primary, Nanda, Anil, additional, Keswani, Anjeni, additional, Adinoff, Allen, additional, Baroody, Fuad M, additional, Bernstein, Jonathan A, additional, Gherasim, Alina, additional, Han, Joseph K, additional, Koepke, Jerald W, additional, Ledford, Dennis K, additional, Pepper, Amber N, additional, Rondón, Carmen, additional, Schiffman, Amy, additional, Wagenmann, Martin, additional, and Campo, Paloma, additional

Published
2023
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23. Sequential class switch recombination to IgE and allergen‐induced accumulation of IgE + plasmablasts occur in the nasal mucosa of local allergic rhinitis patients

Author

Testera‐Montes, Almudena, primary, Palomares, Francisca, additional, Jurado‐Escobar, Raquel, additional, Fernandez‐Santamaria, Ruben, additional, Ariza, Adriana, additional, Verge, Jesus, additional, Salas, Maria, additional, Campo, Paloma, additional, Mayorga, Cristobalina, additional, Torres, Maria Jose, additional, Rondon, Carmen, additional, and Eguiluz‐Gracia, Ibon, additional

Published
2022
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30. Sequential class switch recombination to IgE and allergen‐induced accumulation of IgE+ plasmablasts occur in the nasal mucosa of local allergic rhinitis patients.

Author

Testera‐Montes, Almudena, Palomares, Francisca, Jurado‐Escobar, Raquel, Fernandez‐Santamaria, Ruben, Ariza, Adriana, Verge, Jesus, Salas, Maria, Campo, Paloma, Mayorga, Cristobalina, Torres, Maria Jose, Rondon, Carmen, and Eguiluz‐Gracia, Ibon

Subjects
IMMUNOGLOBULIN class switching, NASAL mucosa, ALLERGIC rhinitis, IMMUNOGLOBULIN E, DERMATOPHAGOIDES pteronyssinus
Abstract

Background: The involvement of allergen‐specific (s)IgE in local allergic rhinitis (LAR) has been debated. Here, we investigate the effect of nasal allergen challenge with Dermatophagoides pteronyssinus (NAC‐DP) in mucosal and peripheral B‐cell subpopulations in LAR patients. Methods: Nine LAR, 5 allergic rhinitis (AR), and 5 non‐atopic healthy control (HC) individuals were subjected to a 3‐day NAC‐DP protocol, and nasal biopsies and blood samples were collected before and after provocation. Nasal biopsies were used for immunohistochemistry and gene expression studies, whereas the frequency of lymphocyte subsets and basophil activation test (BAT) were analyzed in blood samples by flow cytometry. sIgG was measured in sera. Results: NAC‐DP induced an increase in IgE+CD38+ plasmablasts in the nasal mucosa of LAR patients, but not in AR or HC individuals. Markers of sequential recombination to IgE (εCSR) (from IgG) were observed in 33% of LAR, 20% of AR, and 0% of HC subjects. NAC‐DP increased the proportion of peripheral CD19+CD20+CD38+ plasmablasts in AR and LAR patients, but not in HC. Expression of the mucosal homing receptor CXCR3 in peripheral CD19+CD20+CD38+ plasmablasts from LAR, AR, and HC individuals was 7%, 5%, and 0.5%, respectively. In vitro DP stimulation increased proliferating CD19+CD20+CD38+ plasmablasts in LAR and AR patients, but not in HC. Serum DP‐sIgG was higher in LAR and AR patients as compared to HC. BAT was positive in 33%, 100%, and 0% of LAR, AR, and HC subjects, respectively. Conclusion: These results suggest that allergen exposure induces the sequential εCSR of IgG+CD19+CD20+CD38+ plasmablasts in the nasal mucosa of LAR patients. [ABSTRACT FROM AUTHOR]

Published
2022
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31. HLA-DRB1*15:01 allele protects from asthma susceptibility

Author

Pino-Yanes, María, Corrales, Almudena, Acosta-Herrera, Marialbert, Pérez-Rodríguez, Eva, Cumplido, José, Campo, Paloma, Barreto-Luis, Amalia, Sánchez-García, Florentino, Felipe, Tobías, Sánchez-Machín, Inmaculada, Quintela, Inés, García-Robaina, José Carlos, Villar, Jesús, Blanca, Miguel, Carracedo, Angel, Carrillo, Teresa, and Flores, Carlos

Published
2014
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32. Presentacion

Author

Gómez, Juana Martínez, Binns, Niall, del Campo, Paloma Jiménez, Parada, Esperanza López, Alonso, Almudena Mejías, and Sánchez, Evangelina Soltero

Published
2011

33. Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent

Author

Acosta-Herrera, Marialbert, Pino-Yanes, Maria, Ma, Shwu-Fan, Barreto-Luis, Amalia, Corrales, Almudena, Cumplido, José, Pérez-Rodríguez, Eva, Campo, Paloma, Eng, Celeste, García-Robaina, José Carlos, Quintela, Inés, Villar, Jesús, Blanca, Miguel, Carracedo, Ángel, Carrillo, Teresa, Garcia, Joe G.N., Torgerson, Dara G., Burchard, Esteban G., and Flores, Carlos

Published
2015
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36. The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology

Author

Stevens, Whitney W., primary, Jerschow, Elina, additional, Baptist, Alan P., additional, Borish, Larry, additional, Bosso, John V., additional, Buchheit, Kathleen M., additional, Cahill, Katherine N., additional, Campo, Paloma, additional, Cho, Seong H., additional, Keswani, Anjeni, additional, Levy, Joshua M., additional, Nanda, Anil, additional, Laidlaw, Tanya M., additional, and White, Andrew A., additional

Published
2021
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37. Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations

Author

Cornejo-García, José Antonio, Liou, Lieh-Bang, Blanca-López, Natalia, Doña, Inmaculada, Chen, Chien-Hsiun, Chou, Yi-Chun, Chuang, Hui-Ping, Wu, Jer-Yuarn, Chen, Yuan-Tsong, del Carmen Plaza-Serón, María, Mayorga, Cristobalina, Guéant-Rodríguez, Rosa María, Lin, Shih-Chang, Torres, María José, Campo, Paloma, Rondón, Carmen, Laguna, José Julio, Fernández, Javier, Guéant, Jean-Louis, Canto, Gabriela, Blanca, Miguel, and Lee, Ming Ta Michael

Published
2013
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39. Erratum: Benefits and harm of systemic steroids for short- A nd long-term use in rhinitis and rhinosinusitis: An EAACI position paper (Clinical and Translational Allergy (2020) 10 (1) DOI: 10.1186/s13601-019-0303-6)

Author

Hox, Valerie, Lourijsen, Evelijn, Jordens, Arnout, Aasbjerg, Kristian, Agache, Ioana, Alobid, Isam, Bachert, Claus, Boussery, Koen, Campo, Paloma, Fokkens, Wytske, Hellings, Peter, Hopkins, Claire, Klimek, Ludger, Mäkelä, Mika, Mösges, Ralph, Mullol, Joaquim, Pujols, Laura, Rondon, Carmen, Rudenko, Michael, Toppila-Salmi, Sanna, Scadding, Glenis, Scheire, Sophie, Tomazic, Peter-Valentin, van Zele, Thibaut, Wagenmann, Martin, van Boven, Job F. M., Gevaert, Philippe, Ear, Nose and Throat, Graduate School, and AII - Inflammatory diseases

Abstract

Following publication of the original article [1], the authors identified an error in the author name of Martin Wagenmann. The incorrect author name is: Martin Wagemann. The correct author name is: Martin Wagenmann. The author group has been updated above and the original article [1] has been corrected.

Published
2020

40. FENOMA Study: Achieving Full Control in Patients with Severe Allergic Asthma

Author

Cabrejos, Sheila, Moreira, Ana, Ramirez, Andreina, Quirce, Santiago, Soto Campos, Gregorio, Dávila, Ignacio, and Campo, Paloma

Subjects
exacerbations, Journal of Asthma and Allergy, omalizumab, IgE, asthma, allergy
Abstract

Sheila Cabrejos,1 Ana Moreira,2 Andreina Ramirez,2 Santiago Quirce,3 Gregorio Soto Campos,4 Ignacio Dávila,5 Paloma Campo6 1Allergy Service, Hospital Rafael Mendez de Lorca, Murcia, Spain; 2Novartis Farmacéutica, Barcelona, Spain; 3Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, CIBER de Enfermedades Respiratorias, CIBERES, Madrid, Spain; 4Pneumology and Allergy Unit, Hospital Universitario de Jerez, Cádiz, Spain; 5Allergy Service, University Hospital of Salamanca and Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain, Biomedical and Diagnosis Science Department, Salamanca University School of Medicine, Salamanca, Spain; 6Allergy Unit, IBIMA-Regional University Hospital of Málaga, ARADyAL, Málaga, SpainCorrespondence: Ignacio DávilaAllergy Service, University Hospital of Salamanca and Institute for Biomedical Research of Salamanca (IBSAL), Paseo de San Vicente, 58-182, Salamanca 37007, SpainTel +34923291100 (55373)Email idg@usal.esIntroduction: A Spanish real-world study in patients with severe persistent asthma who achieved asthma control after a one-year treatment with omalizumab highlighted the phenotypic heterogeneity of these patients (FENOMA study). In this subanalysis, we describe the clinical improvement in patients with severe allergic asthma in this study (positive skin test and IgE level 30– 1500 IU/mL); n=240.PatientsandMethods: FENOMA was an observational, multicentre, retrospective study in 345 patients achieving asthma control according to Spanish guidelines (GEMA). Baseline demographic and asthma-related characteristics were collected. Outcomes analyzed were those included in asthma control definition plus changes in background treatments and in blood eosinophil count (%) and exhaled nitric oxide fraction [FeNO].Results: At baseline, patients were aged 45.4± 15.0 years; 67% were women. Median (Q1;Q3) IgE levels were 302.5 (154.0; 553.5) IU/mL. After one-year treatment with omalizumab: 43.3% of patients had daytime symptoms vs 97.7% before treatment and 49.6% stopped taking oral corticosteroids. FEV1 increased a median of 12.0 (4.0; 23.0)%; P < 0.0001. The number of non-severe asthma exacerbations decreased a median of − 4.0 (− 7.0; 2.0); P < 0.0001. Median unplanned visits to primary care or specialists and days of school/workplace absenteeism decreased from 4.9 (2.0; 6.0), 1.0 (0.0; 3.0) and 0.0 (0.0; 14.0) to 0.0 (0.0; 1.0), 0.0 (0.0; 0.0) and 0.0 (0.0; 0.0), respectively. Median eosinophil blood count and FeNO decreased from 5.0 (3:0; 8.0)% to 3.0 (2.0; 5.5)% and from 36.0 (23:0; 53.0) ppb to 20.0 (13.0; 34.0) ppb, respectively.Conclusion: This study highlights the asthma control achieved by patients with severe allergic asthma treated with omalizumab, with relevant benefits on the burden of the disease both on patients and the healthcare system.Keywords: asthma, omalizumab, allergy, exacerbations, IgE

Published
2020

41. Additional file 1 of Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Author

Hox, Valerie, Lourijsen, Evelijn, Jordens, Arnout, Aasbjerg, Kristian, Agache, Ioana, Alobid, Isam, Bachert, Claus, Boussery, Koen, Campo, Paloma, Fokkens, Wytske, Hellings, Peter, Hopkins, Claire, Klimek, Ludger, Mäkelä, Mika, Mösges, Ralph, Mullol, Joaquim, Pujols, Laura, Rondon, Carmen, Rudenko, Michael, Toppila-Salmi, Sanna, Glenis Scadding, Scheire, Sophie, Peter-Valentin Tomazic, Zele, Thibaut Van, Wagenmann, Martin, Boven, Job F. M. Van, and Gevaert, Philippe

Subjects
Data_FILES
Abstract

Additional file 1. Search terms.

Published
2020
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42. MOESM1 of Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Author

Hox, Valerie, Lourijsen, Evelijn, Jordens, Arnout, Aasbjerg, Kristian, Agache, Ioana, Alobid, Isam, Bachert, Claus, Boussery, Koen, Campo, Paloma, Fokkens, Wytske, Hellings, Peter, Hopkins, Claire, Klimek, Ludger, Mäkelä, Mika, Mösges, Ralph, Mullol, Joaquim, Pujols, Laura, Rondon, Carmen, Rudenko, Michael, Toppila-Salmi, Sanna, Glenis Scadding, Scheire, Sophie, Peter-Valentin Tomazic, Zele, Thibaut, Wagemann, Martin, Boven, Job, and Gevaert, Philippe

Subjects
Data_FILES
Abstract

Additional file 1. Search terms.

Published
2020
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44. Transferencia de saberes y de textos en el archivo virreinal de las Indias /Esperanza López Parada, Paloma Jiménez del Campo, Evangelina Soltero Sánchez (eds.).

Author

López Parada, Esperanza, Jiménez del Campo, Paloma, Soltero Sánche, Evangelina (eds.), López Parada, Esperanza, Jiménez del Campo, Paloma, and Soltero Sánche, Evangelina (eds.)

Abstract

El estudio de la transferencia entre el Nuevo y el Viejo Mundo, objeto de estudio del presente volumen de artículos, parte en primera instancia del concepto de archivo pensado en un sentido amplio, no sólo en tanto repositorio de documentos y de dispositivo para la imposición del poder imperial, sino en las acepciones de “lugar de la memoria” y de “metáfora epistémica” que permite la interpretación “arqueológica” de los saberes. Del mismo modo, el fenómeno de transmisiones que lo conforman se analiza aquí desde los dos lados y las dos direccionalidades de los ámbitos implicados, con la ayuda de especialistas internacionales que insisten con sus acercamientos en la diversidad compositiva de estas escrituras transferidas. El libro ofrece ejemplos muy distintos de ese intercambio que conformó la realidad americana, cartografiando de esta forma las isobaras de los préstamos a lo largo de los tres siglos de existencia de los virreinatos, así como el diagnóstico de su integración en la historia de transculturaciones y trasvases que los caracterizan.

Published
2022

50. Coexistence of nasal reactivity to allergens with and without IgE sensitization in patients with allergic rhinitis

Author

Eguiluz‐Gracia, Ibon, primary, Fernandez‐Santamaria, Ruben, additional, Testera‐Montes, Almudena, additional, Ariza, Adriana, additional, Campo, Paloma, additional, Prieto, Ana, additional, Perez‐Sanchez, Natalia, additional, Salas, Maria, additional, Mayorga, Cristobalina, additional, Torres, Maria Jose, additional, and Rondon, Carmen, additional

Published
2020
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