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214 results on '"Campo, M. S."'

2. Vaccination Against Papillomavirus in Cattle

Author

Campo, M. S., Capron, A., editor, Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, McConnell, I., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, and zur Hausen, Harald, editor

Published
1994
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4. DNA-RNA Hybridization

Author

Bishop, J. O., Beckman, J. S., Campo, M. S., Hastie, N. D., Izquierdo, M., and Perlman, S.

Published
1975

45. Novel variants of human papillomavirus type 2 in warts from immunocompromised individuals.

Author

Wilson, C. A. B., Holmes, S. C., Campo, M. S., White, S. I., Tillman, D., Mackie, R. M., and Thomson, J.

Subjects
WARTS, SKIN infections, HODGKIN'S disease, LYMPHOMAS, NUCLEOTIDE sequence, PAPILLOMA
Abstract

Twenty cutaneous warts from 18 renal transplant recipients (RTR) and a single wart sample from a patient suffering from Hodgkin's disease were screened for the presence of human papillomavirus (HPV) sequences by Southern blot analysis. Thirteen samples were shown to contain HPV DNA sequences, one was identified as HPV-3, two as HPV-4, six as HPV-2 and four were unidentifiable by restriction digest analysis. HPV-3 was identified in the wart sample from the patient suffering from Hodgkin's disease. In the six samples in which HPV-2 was found, the viral genome showed polymorphism for the PvuII and PstI sites. Two PvuII patterns and one PstI pattern are novel. [ABSTRACT FROM AUTHOR]

Published
1989
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46. Bovine Papillomavirus Type 4 in Oesophageal Papillomas of Cattle from the South of Italy

Author

Borzacchiello, G., Ambrosio, V., Roperto, S., Poggiali, F., Tsirimonakis, E., Venuti, A., Campo, M. S., and Roperto, F.

Abstract

Oesophageal papillomas are known to occur in cattle infected with bovine papillomavirus type 4 (BPV-4), and BPV-4 papillomas may undergo malignant progression in cattle that feed on bracken fern. In the south of Italy, where bracken fern is common, examination of 1133 slaughterhouse cattle aged 4–12 years revealed oesophageal lesions (single or multiple peduncuolated proliferations, or mucosal thickening) in 147 (13%). These two types of lesion were consistent with exophytic and inverted papilloma, respectively. BPV-4 was detected by polymerase chain reaction (PCR) analysis in >60% of the samples in which oesophageal papilloma was diagnosed histopathologically. Nucleotide sequencing of the PCR amplicons confirmed the presence of BPV-4 in the papillomas. This is the first report of such infections in a European country other than Britain.

Published
2003
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47. Quercetin, E7 and p53 in papillomavirus oncogenic cell transformation.

Author

Beniston, R G, Morgan, I M, O'Brien, V, and Campo, M S

Abstract

Bovine papillomavirus type 4 (BPV-4) infects the upper alimentary canal of cattle causing benign papillomas which can progress to squamous carcinomas in cattle grazing on bracken fern (BF). We have previously shown that quercetin, a well characterized and potent mutagen found in BF, causes cell cycle arrest of primary bovine cells (PalF), but that a single exposure to quercetin can cause full oncogenic transformation of PalF cells partially transformed by BPV-4. Here we show that cell cycle arrest correlates with an increase in p53 protein levels and transcriptional activity. However, in cells transformed but non-tumorigenic, p53 protein is elevated and transcriptionally activated in response to quercetin or other DNA damaging stimuli, but the cells bypass quercetin-induced G1 arrest likely due to E7 expression. In transformed tumorigenic cells, p53 is elevated in response to quercetin but its transcriptional activity is inhibited due to mutation, and the cells fail to stop in G1 in the presence of quercetin.

Published
2001
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48. An enhanced epithelial response of a papillomavirus promoter to transcriptional activators.

Author

Vance, K W, Campo, M S, and Morgan, I M

Abstract

Mucosal epitheliotropic papillomaviruses have a similar long control region (LCR) organization: a promoter region, an enhancer region, and a highly conserved distribution of E2 DNA binding sites. The enhancer of these viruses is epithelial-specific, as it fails to activate transcription from heterologous promoters in nonepithelial cell types (Gloss, B., Bernard, H. U., Seedorf, K., and Klock, G. (1987) EMBO J. 6, 3735-3743; Morgan, I. M., Grindlay, G. J., and Campo, M. S. (1999) J. Gen. Virol. 80, 23-27). Studies on E2 transcriptional regulation of the human mucosal epitheliotropic papillomaviruses have been hindered by poor access to the natural target cell type and by the observation that some of the human papillomavirus promoters, including human papillomavirus-16, are repressed in immortalized epithelial cells. Here we present results using the bovine papillomavirus-4 (BPV-4) LCR and a bovine primary cell system as a model to study the mechanism of E2 transcriptional regulation of mucosal epitheliotropic papillomaviruses and the cell type specificity of this regulation. E2 up-regulates transcription from the BPV-4 LCR preferentially in epithelial cells (Morgan, I. M., Grindlay, G. J., and Campo, M. S. (1998) J. Gen. Virol. 79, 501-508). We demonstrate that the epithelial-specific enhancer element of the BPV-4 LCR is not required for the enhanced activity of E2 in epithelial cells and that the BPV-4 promoter is more responsive, not only to E2, but to other transcriptional activators in epithelial cells. This is the first time a level of epithelial specificity has been shown to reside in a papillomavirus promoter region.

Published
1999

49. Unintegrated viral DNA sequences in a hamster tumor induced by bovine papilloma virus

Author

Moar, M H, Campo, M S, Laird, H M, and Jarrett, W F

Abstract

A fibrosarcoma was induced in a hamster by bovine papilloma virus type 2 (BPV2). The content of BPV2 DNA sequences was measured by DNA-DNA and cRNA-DNA hybridizations. The tumor contained approximately 300 BPV2 genome equivalents per cell. Southern blot hybridization indicated that the viral DNA was in free form, the entire genome most likely being present. In situ hybridization with BPV2 cRNA showed that multiple genome copies were present in each cell. Neither virus particles nor virus coat antigens could be detected in the tumor. A cell line was established from the fibrosarcoma, and the cells contained multiple copies of the BPV2 genome. The latter was in free form, and all of the DNA sequences appeared to be present in multiple copies and in all cells. An extensive search failed to reveal the presence of virus or viral antigens.

Published
1981
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50. Human papillomaviruses

Author

Arbyn, M., Bosch, X., Cuzick, J., Denny, L., Galloway, D., Giuliano, A. R., Herrero, R., Lambert, P., Lawson, H., Meijer, C. J. L. M., Palefsky, J., Pawlita, M., Qiao, Y. -L, Schiffman, M., Shin, H. -R, Sideri, M., Strickler, H. D., Ballegooijen, M., Villa, L. L., Wong, M., Zur Hausen, H., Campo, M. S., Franco, E. L., Iftner, T., Pfister, H., Gruber, J., Baan, R. A., Boulch, D., Bouvard, V., Clifford, G., Cogliano, V. J., Dai, M., Dikshit, R., Dresler, C., El Ghissassi, F., silvia franceschi, Goncalves, M. A., Grosse, Y., Guha, N., Hasan, U., Hsu, C., Kreimer, A., Krutovskikh, V., Mitchell, J., Napalkov, N., Uhe, S. P., Plummer, M., Secretan, B., Straif, K., Sylla, B., Tommasino, M., Vaccarella, S., Egraz, S., Javin, M., Kajo, B., Lézère, M., Mollon, G., and Perez, E.

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