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Purpose: Analysis of [18F]-Fluorodeoxyglucose (FDG) kinetics in cancer has been most often limited to the evaluation of the average uptake over relatively large volumes. Nevertheless, tumor lesion almost contains inflammatory infiltrates whose cells are characterized by a significant radioactivity washout due to the hydrolysis of FDG-6P catalyzed by glucose-6P phosphatase. The present study aimed to verify whether voxel-wise compartmental analysis of dynamic imaging can identify tumor regions characterized by tracer washout. Materials & Methods: The study included 11 patients with lung cancer submitted to PET/CT imaging for staging purposes. Tumor was defined by drawing a volume of interest loosely surrounding the lesion and considering all inside voxels with standardized uptake value (SUV) >40% of the maximum. After 20 minutes dynamic imaging centered on the heart, eight whole body scans were repeated. Six parametric maps were progressively generated by computing six regression lines that considered all eight frames, the last seven ones, and so on, up to the last three. Results: Progressively delaying the starting point of regression line computation identified a progressive increase in the prevalence of voxels with a negative slope. Conclusions: The voxel-wise parametric maps provided by compartmental analysis permits to identify a measurable volume characterized by radioactivity washout. The spatial localization of this pattern is compatible with the recognized preferential site of inflammatory infiltrates populating the tumor stroma and might improve the power of FDG imaging in monitoring the effectiveness of treatments aimed to empower the host immune response against the cancer.

AI-FLARES (Artificial Intelligence for the Analysis of Solar Flares Data) is a research project funded by the Agenzia Spaziale Italiana and by the Istituto Nazionale di Astrofisica within the framework of the ``Attivit\`a di Studio per la Comunit\`a Scientifica Nazionale Sole, Sistema Solare ed Esopianeti'' program. The topic addressed by this project was the development and use of computational methods for the analysis of remote sensing space data associated to solar flare emission. This paper overviews the main results obtained by the project, with specific focus on solar flare forecasting, reconstruction of morphologies of the flaring sources, and interpretation of acceleration mechanisms triggered by solar flares.

The analysis of the psoas muscle in morphological and functional imaging has proved to be an accurate approach to assess sarcopenia, i.e. a systemic loss of skeletal muscle mass and function that may be correlated to multifactorial etiological aspects. The inclusion of sarcopenia assessment into a radiological workflow would need the implementation of computational pipelines for image processing that guarantee segmentation reliability and a significant degree of automation. The present study utilizes three-dimensional numerical schemes for psoas segmentation in low-dose X-ray computed tomography images. Specifically, here we focused on the level set methodology and compared the performances of two standard approaches, a classical evolution model and a three-dimension geodesic model, with the performances of an original first-order modification of this latter one. The results of this analysis show that these gradient-based schemes guarantee reliability with respect to manual segmentation and that the first-order scheme requires a computational burden that is significantly smaller than the one needed by the second-order approach.

The project CAESAR (Comprehensive spAce wEather Studies for the ASPIS prototype Realization) is aimed to tackle all the relevant aspects of Space Weather (SWE) and realize the prototype of the scientific data centre for Space Weather of the Italian Space Agency (ASI) called ASPIS (ASI SPace Weather InfraStructure). This contribution is meant to bring attention upon the first steps in the development of the CAESAR prototype for ASPIS and will focus on the activities of the Node 2000 of CAESAR, the set of Work Packages dedicated to the technical design and implementation of the CAESAR ASPIS archive prototype. The product specifications of the intended resources that will form the archive, functional and system requirements gathered as first steps to seed the design of the prototype infrastructure, and evaluation of existing frameworks, tools and standards, will be presented as well as the status of the project in its initial stage., Comment: 4 pages, 2 figures, ADASS XXXII (2022) Proceedings

In many contexts, customized and weighted classification scores are designed in order to evaluate the goodness of the predictions carried out by neural networks. However, there exists a discrepancy between the maximization of such scores and the minimization of the loss function in the training phase. In this paper, we provide a complete theoretical setting that formalizes weighted classification metrics and then allows the construction of losses that drive the model to optimize these metrics of interest. After a detailed theoretical analysis, we show that our framework includes as particular instances well-established approaches such as classical cost-sensitive learning, weighted cross entropy loss functions and value-weighted skill scores.

Operational flare forecasting aims at providing predictions that can be used to make decisions, typically at a daily scale, about the space weather impacts of flare occurrence. This study shows that video-based deep learning can be used for operational purposes when the training and validation sets used for the network optimization are generated while accounting for the periodicity of the solar cycle. Specifically, the paper describes an algorithm that can be applied to build up sets of active regions that are balanced according to the flare class rates associated to a specific cycle phase. These sets are used to train and validate a Long-term Recurrent Convolutional Network made of a combination of a convolutional neural network and a Long-Short Memory network. The reliability of this approach is assessed in the case of two prediction windows containing the solar storm of March 2015 and September 2017, respectively.

Solar flare forecasting can be realized by means of the analysis of magnetic data through artificial intelligence techniques. The aim is to predict whether a magnetic active region (AR) will originate solar flares above a certain class within a certain amount of time. A crucial issue is concerned with the way the adopted machine learning method is implemented, since forecasting results strongly depend on the criterion with which training, validation, and test sets are populated. In this paper we propose a general paradigm to generate these sets in such a way that they are independent from each other and internally well-balanced in terms of AR flaring effectiveness. This set generation process provides a ground for comparison for the performance assessment of machine learning algorithms. Finally, we use this implementation paradigm in the case of a deep neural network, which takes as input videos of magnetograms recorded by the Helioseismic and Magnetic Imager on-board the Solar Dynamics Observatory (SDO/HMI). To our knowledge, this is the first time that the solar flare forecasting problem is addressed by means of a deep neural network for video classification, which does not require any a priori extraction of features from the HMI magnetograms.

Solar flares emanate from solar active regions hosting complex and strong bipolar magnetic fluxes. Estimating the probability of an active region to flare and defining reliable precursors of intense flares is an extremely challenging task in the space weather field. In this work, we focus on two metrics as flare precursors, the unsigned flux R, tested on MDI/SOHO data and one of the most used parameters for flare forecasting applications, and a novel topological parameter D representing the complexity of a solar active region. More in detail, we propose an algorithm for the computation of the R value which exploits the higher spatial resolution of HMI maps. This algorithm leads to a differently computed R value, whose functionality is tested on a set of cycle 24th solar flares. Furthermore, we introduce a topological parameter based on the automatic recognition of magnetic polarity-inversion lines in identified active regions, and able to evaluate its magnetic topological complexity. We use both a heuristic approach and a supervised machine learning method to validate the effectiveness of these two descriptors to predict the occurrence of X- or M- class flares in a given solar active region during the following 24 hours period. Our feature ranking analysis shows that both parameters play a significant role in prediction performances. Moreover, the analysis demonstrates that the new topological parameter D is the only one, among 173 overall predictors, which is always present for all test subsets and is systematically ranked within the top-ten positions in all tests concerning the computation of the weighs with which each predictor impacts the flare forecasting., Comment: 16 pages, 8 figures, accepted in the Astrophysical Journal

Loss functions engineering and the assessment of forecasting performances are two crucial and intertwined aspects of supervised machine learning. This paper focuses on binary classification to introduce a class of loss functions that are defined on probabilistic confusion matrices and that allow an automatic and a priori maximization of the skill scores. The performances of these loss functions are validated during the training phase of two experimental forecasting problems, thus showing that the probability distribution function associated with the confusion matrices significantly impacts the outcome of the score maximization process.

To analyse multimodal 3-dimensional medical images, interpolation is required for resampling which - unavoidably - introduces an interpolation error. In this work we consider three segmented 3-dimensional images resampled with three different neuroimaging software tools for comparing undersampling and oversampling strategies and to identify where the oversampling error lies. The results indicate that undersampling to the lowest image size is advantageous in terms of mean value per segment errors and that the oversampling error is larger where the gradient is steeper, showing a Gibbs effect.

Machine learning is nowadays the methodology of choice for flare forecasting and supervised techniques, in both their traditional and deep versions, are becoming the most frequently used ones for prediction in this area of space weather. Yet, machine learning has not been able so far to realize an operating warning system for flaring storms and the scientific literature of the last decade suggests that its performances in the prediction of intense solar flares are not optimal. The main difficulties related to forecasting solar flaring storms are probably two. First, most methods are conceived to provide probabilistic predictions and not to send binary yes/no indications on the consecutive occurrence of flares along an extended time range. Second, flaring storms are typically characterized by the explosion of high energy events, which are seldom recorded in the databases of space missions; as a consequence, supervised methods are trained on very imbalanced historical sets, which makes them particularly ineffective for the forecasting of intense flares. Yet, in this study we show that supervised machine learning could be utilized in a way to send timely warnings about the most violent and most unexpected flaring event of the last decade, and even to predict with some accuracy the energy budget daily released by magnetic reconnection during the whole time course of the storm. Further, we show that the combination of sparsity-enhancing machine learning and feature ranking could allow the identification of the prominent role that energy played as an Active Region property in the forecasting process.

Multiple Myeloma (MM) is a blood cancer implying bone marrow involvement, renal damages and osteolytic lesions. The skeleton involvement of MM is at the core of the present paper, exploiting radiomics and artificial intelligence to identify image-based biomarkers for MM. Preliminary results show that MM is associated to an extension of the intrabone volume for the whole body and that machine learning can identify CT image features mostly correlating with the disease evolution. This computational approach allows an automatic stratification of MM patients relying of these biomarkers and the formulation of a prognostic procedure for determining the disease follow-up.

Solar flares originate from magnetically active regions but not all solar active regions give rise to a flare. Therefore, the challenge of solar flare prediction benefits by an intelligent computational analysis of physics-based properties extracted from active region observables, most commonly line-of-sight or vector magnetograms of the active-region photosphere. For the purpose of flare forecasting, this study utilizes an unprecedented 171 flare-predictive active region properties, mainly inferred by the Helioseismic and Magnetic Imager onboard the Solar Dynamics Observatory (SDO/HMI) in the course of the European Union Horizon 2020 FLARECAST project. Using two different supervised machine learning methods that allow feature ranking as a function of predictive capability, we show that: i) an objective training and testing process is paramount for the performance of every supervised machine learning method; ii) most properties include overlapping information and are therefore highly redundant for flare prediction; iii) solar flare prediction is still - and will likely remain - a predominantly probabilistic challenge.

To meet the current need for skeletal tumor-load estimation in prostate cancer (mCRPC), we developed a novel approach, based on adaptive bone segmentation. In this study, we compared the program output with existing estimates and with the radiological outcome. Seventy-six whole-body 99mTc-DPD-SPECT/CT from mCRPC patients were analyzed. The software identified the whole skeletal volume (SVol) and classified it voxels metastases (MVol) or normal bone (BVol). SVol was compared with the estimation of a commercial software. MVol was compared with manual assessment and with PSA-level. Counts/voxel were extracted from MVol and BVol. After six cycles of 223RaCl2-therapy every patient was re-evaluated as progressing (PD), stabilized (SD) or responsive (PR). SVol correlated with the one of the commercial software (R=0,99, p<0,001). MVol correlated with manually-counted lesions (R=0,61, p<0,001) and PSA (R=0,46, p<0.01). PD had a lower counts/voxel in MVol than PR/SD (715 \pm 190 Vs. 975 \pm 215 and 1058 \pm 255, p<0,05 and p<0,01) and in BVol (PD 275 \pm 60, PR 515 \pm 188 and SD 528 \pm 162 counts/voxel, p<0,001). Segmentation-based tumor load correlated with radiological/laboratory indices. Uptake was linked with the clinical outcome, suggesting that metastases in PD patients have a lower affinity for bone-seeking radionuclides and might benefit less from bone-targeted radioisotope therapies.

In the framework of the Hough transform technique to detect curves in images, we provide a bound for the number of Hough transforms to be considered for a successful optimization of the accumulator function in the recognition algorithm. Such a bound is consequence of geometrical arguments. We also show the robustness of the results when applied to synthetic datasets strongly perturbed by noise. An algebraic approach, discussed in the appendix, leads to a better bound of theoretical interest in the exact case.

We describe here the application of a machine learning method for flare forecasting using vectors of properties extracted from images provided by the Helioseismic and Magnetic Imager in the Solar Dynamics Observatory (SDO/HMI). We also discuss how the method can be used to quantitatively assess the impact of such properties on the prediction process., Comment: submitted to 'Nuovo Cimento' as proceeding of SOHE3

'Flare Likelihood and Region Eruption Forecasting (FLARECAST)' is a Horizon 2020 project, which realized a technological platform for machine learning algorithms, with the objective of providing the space weather community with a prediction service for solar flares. This paper describes the FLARECAST service and shows how the methods implemented in the platform allow both flare prediction and a quantitative assessment of how the information contained in the space data utilized in the analysis may impact the forecasting process., Comment: IEEE Italy Session - 4th International Forum on Research and Technologies for Society and Industry

We introduce a hybrid approach to solar flare prediction, whereby a supervised regularization method is used to realize feature importance and an unsupervised clustering method is used to realize the binary flare/no-flare decision. The approach is validated against NOAA SWPC data.