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6 results on '"Campesato, L"'

1. Immunoengineering in glioblastoma imaging and therapy

Author

Zanganeh, S, Georgala, P, Corbo, C, Arabi, L, Ho, J, Javdani, N, Sepand, M, Cruickshank, K, Campesato, L, Weng, C, Hemayat, S, Andreou, C, Alvim, R, Hutter, G, Rafat, M, Mahmoudi, M, Zanganeh S., Georgala P., Corbo C., Arabi L., Ho J. Q., Javdani N., Sepand M. R., Cruickshank K., Campesato L. F., Weng C. -H., Hemayat S., Andreou C., Alvim R., Hutter G., Rafat M., Mahmoudi M., Zanganeh, S, Georgala, P, Corbo, C, Arabi, L, Ho, J, Javdani, N, Sepand, M, Cruickshank, K, Campesato, L, Weng, C, Hemayat, S, Andreou, C, Alvim, R, Hutter, G, Rafat, M, Mahmoudi, M, Zanganeh S., Georgala P., Corbo C., Arabi L., Ho J. Q., Javdani N., Sepand M. R., Cruickshank K., Campesato L. F., Weng C. -H., Hemayat S., Andreou C., Alvim R., Hutter G., Rafat M., and Mahmoudi M.

Abstract

Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood–brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy and nanotechnology have demonstrated potential in addressing these obstacles by enabling precise targeting of brain tumors to minimize adverse effects, while increasing targeted drug delivery across the BBB. In addition to treating the tumors, these approaches may be used in conjunction with imaging modalities, such as magnetic resonance imaging and positron emission tomography to enhance the prognosis procedures. This review aims to provide mechanistic understanding of immune system regulation in the central nervous system and the benefits of nanoparticles in the prognosis of brain tumors. This article is characterized under:. Diagnostic Tools ' in vivo Nanodiagnostics and Imaging. Nanotechnology Approaches to Biology ' Cells at the Nanoscale. Nanotechnology Approaches to Biology ' Nanoscale Systems in Biology.

Published
2019

5. Immunoengineering in glioblastoma imaging and therapy

Author

Zanganeh, Steven, Georgala, Petrina, Corbo, Claudia, Arabi, Leila, Ho, Jim Q., Javdani, Najme, Sepand, Mohammad R., Cruickshank, Kiara, Campesato, Luis F., Weng, Chien-Huan, Hemayat, Saeed, Andreou, Chrysafis, Alvim, Ricardo, Hutter, Gregor, Rafat, Marjan, Mahmoudi, Morteza, Andreou, Chrysafis [0000-0002-3464-9110], Zanganeh, S, Georgala, P, Corbo, C, Arabi, L, Ho, J, Javdani, N, Sepand, M, Cruickshank, K, Campesato, L, Weng, C, Hemayat, S, Andreou, C, Alvim, R, Hutter, G, Rafat, M, and Mahmoudi, M

Subjects
Diagnostic Imaging, medicine.medical_treatment, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, 02 engineering and technology, 010402 general chemistry, Bioinformatics, 01 natural sciences, Theranostic Nanomedicine, medicine, Animals, Humans, Nanotechnology, Adverse effect, Chemotherapy, medicine.diagnostic_test, Brain Neoplasms, business.industry, imaging, Magnetic resonance imaging, Immunotherapy, 021001 nanoscience & nanotechnology, nanomedicine, 0104 chemical sciences, Radiation therapy, immunoengineering, Targeted drug delivery, Positron emission tomography, Nanoparticles, Nanomedicine, Glioblastoma, 0210 nano-technology, business
Abstract

Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood–brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy and nanotechnology have demonstrated potential in addressing these obstacles by enabling precise targeting of brain tumors to minimize adverse effects, while increasing targeted drug delivery across the BBB. In addition to treating the tumors, these approaches may be used in conjunction with imaging modalities, such as magnetic resonance imaging and positron emission tomography to enhance the prognosis procedures. This review aims to provide mechanistic understanding of immune system regulation in the central nervous system and the benefits of nanoparticles in the prognosis of brain tumors. This article is characterized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Cells at the Nanoscale Nanotechnology Approaches to Biology > Nanoscale Systems in Biology 11 6

Published
2019
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6. A Full QM Computational Study of the Catalytic Mechanism of α-1,4-Glucan Lyases.

Author

Campesato L, Marforio TD, Giacinto P, Calvaresi M, and Bottoni A

Subjects
Biocatalysis, Glycosylation, Seaweed enzymology, Solvents chemistry, Thermodynamics, Models, Molecular, Polysaccharide-Lyases metabolism, Quantum Theory
Abstract

We investigated the catalytic mechanism of α-1,4-glucan lyases using a full QM DFT approach based on the M06-2X functional. The reaction profile of the whole catalytic process can be divided into three phases: glycosylation, deglycosylation-elimination and tautomerization. Glycosylation is a highly asynchronous S N 1-like process with an energy barrier of 10.2 kcal mol -1 . A proton moves from the Asp 665 residue to the glycosidic oxygen. Asp 553 acts as a nucleophile and attacks the anomeric carbon causing the cleavage of the glycosidic bond. Deglycosilation-elimination is the rate-determining step of the entire process with an overall barrier of 18.3 kcal mol -1 . The final step (restoring the catalyst and tautomerization) occurs rather easily, since the Asp 553 carboxylate group "assists" the proton transfer in the tautomerization process. Our computations clearly indicate that tautomerization must occur inside the enzyme before leaving the active site rather than in the aqueous solution. Outside of the protein environment the enol-AF→keto-AF process "assisted" by a water molecule has a barrier of 35.8 kcal mol -1 ., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2018
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