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19,638 results on '"Campbell, J."'

1. Proof of the geometric Langlands conjecture II: Kac-Moody localization and the FLE

Author

Arinkin, D., Beraldo, D., Campbell, J., Chen, L., Faergeman, J., Gaitsgory, D., Lin, K., Raskin, S., and Rozenblyum, N.

Subjects
Mathematics - Algebraic Geometry
Abstract

This paper is the second in a series of five that together prove the geometric Langlands conjecture. Our goals are two-fold: (1) Formulate and prove the Fundamental Local Equivalence (FLE) at the critical level; (2) Study the interaction between Kac-Moody localization and the global geometric Langlands functor of ref. [GLC1]. This paper contains an extensive Appendix, whose primary goals are: (a) Development the theory of ind-coherent sheaves in infinite type; (b)Development of the formalism of factorization categories.

Published
2024

2. Development of a Semi-automated Computer-based Tool for the Quantification of Vascular Tortuosity in the Murine Retina.

Author

Marra, Kyle, Chen, Jimmy, Robles-Holmes, Hailey, Miller, Joseph, Wei, Guoqin, Aguilar, Edith, Ideguchi, Yoichiro, Ly, Kristine, Prenner, Sofia, Erdogmus, Deniz, Ferrara, Napoleone, Campbell, J, Friedlander, Martin, and Nudleman, Eric

Subjects
Computer-based image analysis, Oxygen-induced retinopathy, Vessel tortuosity
Abstract

PURPOSE: The murine oxygen-induced retinopathy (OIR) model is one of the most widely used animal models of ischemic retinopathy, mimicking hallmark pathophysiology of initial vaso-obliteration (VO) resulting in ischemia that drives neovascularization (NV). In addition to NV and VO, human ischemic retinopathies, including retinopathy of prematurity (ROP), are characterized by increased vascular tortuosity. Vascular tortuosity is an indicator of disease severity, need to treat, and treatment response in ROP. Current literature investigating novel therapeutics in the OIR model often report their effects on NV and VO, and measurements of vascular tortuosity are less commonly performed. No standardized quantification of vascular tortuosity exists to date despite this metrics relevance to human disease. This proof-of-concept study aimed to apply a previously published semi-automated computer-based image analysis approach (iROP-Assist) to develop a new tool to quantify vascular tortuosity in mouse models. DESIGN: Experimental study. SUBJECTS: C57BL/6J mice subjected to the OIR model. METHODS: In a pilot study, vasculature was manually segmented on flat-mount images of OIR and normoxic (NOX) mice retinas and segmentations were analyzed with iROP-Assist to quantify vascular tortuosity metrics. In a large cohort of age-matched (postnatal day 12 [P12], P17, P25) NOX and OIR mice retinas, NV, VO, and vascular tortuosity were quantified and compared. In a third experiment, vascular tortuosity in OIR mice retinas was quantified on P17 following intravitreal injection with anti-VEGF (aflibercept) or Immunoglobulin G isotype control on P12. MAIN OUTCOME MEASURES: Vascular tortuosity. RESULTS: Cumulative tortuosity index was the best metric produced by iROP-Assist for discriminating between OIR mice and NOX controls. Increased vascular tortuosity correlated with disease activity in OIR. Treatment of OIR mice with aflibercept rescued vascular tortuosity. CONCLUSIONS: Vascular tortuosity is a quantifiable feature of the OIR model that correlates with disease severity and may be quickly and accurately quantified using the iROP-Assist algorithm. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Published
2024

3. Genome-wide association identifies novel ROP risk loci in a multiethnic cohort

Author

Li, Xiaohui, Owen, Leah A, Taylor, Kent D, Ostmo, Susan, Chen, Yii-Der Ida, Coyner, Aaron S, Sonmez, Kemal, Hartnett, M Elizabeth, Guo, Xiuqing, Ipp, Eli, Roll, Kathryn, Genter, Pauline, Chan, RV Paul, DeAngelis, Margaret M, Chiang, Michael F, Campbell, J Peter, and Rotter, Jerome I

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Ophthalmology and Optometry, Human Genome, Biotechnology, Eye Disease and Disorders of Vision, Perinatal Period - Conditions Originating in Perinatal Period, Prevention, Pediatric, Rare Diseases, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Eye, Infant, Newborn, Humans, Genome-Wide Association Study, Retinopathy of Prematurity, Ethnicity, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, i-ROP Consortium, Biological sciences, Biomedical and clinical sciences
Abstract

We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness, identifying 1 locus at genome-wide significance level (p

Published
2024

4. Applications of Deep Learning: Automated Assessment of Vascular Tortuosity in Mouse Models of Oxygen-Induced Retinopathy.

Author

Chen, Jimmy, Marra, Kyle, Robles-Holmes, Hailey, Ly, Kristine, Miller, Joseph, Wei, Guoqin, Aguilar, Edith, Bucher, Felicitas, Ideguchi, Yoichi, Coyner, Aaron, Ferrara, Napoleone, Campbell, J, Friedlander, Martin, and Nudleman, Eric

Subjects
Artificial intelligence, Data science, Oxygen-induced retinopathy, Vascular tortuosity
Abstract

OBJECTIVE: To develop a generative adversarial network (GAN) to segment major blood vessels from retinal flat-mount images from oxygen-induced retinopathy (OIR) and demonstrate the utility of these GAN-generated vessel segmentations in quantifying vascular tortuosity. DESIGN: Development and validation of GAN. SUBJECTS: Three datasets containing 1084, 50, and 20 flat-mount mice retina images with various stains used and ages at sacrifice acquired from previously published manuscripts. METHODS: Four graders manually segmented major blood vessels from flat-mount images of retinas from OIR mice. Pix2Pix, a high-resolution GAN, was trained on 984 pairs of raw flat-mount images and manual vessel segmentations and then tested on 100 and 50 image pairs from a held-out and external test set, respectively. GAN-generated and manual vessel segmentations were then used as an input into a previously published algorithm (iROP-Assist) to generate a vascular cumulative tortuosity index (CTI) for 20 image pairs containing mouse eyes treated with aflibercept versus control. MAIN OUTCOME MEASURES: Mean dice coefficients were used to compare segmentation accuracy between the GAN-generated and manually annotated segmentation maps. For the image pairs treated with aflibercept versus control, mean CTIs were also calculated for both GAN-generated and manual vessel maps. Statistical significance was evaluated using Wilcoxon signed-rank tests (P ≤ 0.05 threshold for significance). RESULTS: The dice coefficient for the GAN-generated versus manual vessel segmentations was 0.75 ± 0.27 and 0.77 ± 0.17 for the held-out test set and external test set, respectively. The mean CTI generated from the GAN-generated and manual vessel segmentations was 1.12 ± 0.07 versus 1.03 ± 0.02 (P = 0.003) and 1.06 ± 0.04 versus 1.01 ± 0.01 (P < 0.001), respectively, for eyes treated with aflibercept versus control, demonstrating that vascular tortuosity was rescued by aflibercept when quantified by GAN-generated and manual vessel segmentations. CONCLUSIONS: GANs can be used to accurately generate vessel map segmentations from flat-mount images. These vessel maps may be used to evaluate novel metrics of vascular tortuosity in OIR, such as CTI, and have the potential to accelerate research in treatments for ischemic retinopathies. FINANCIAL DISCLOSURES: The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Published
2024

7. A Retrospective, Observational Study of 12 Cases of Expanded-Access Customized Phage Therapy: Production, Characteristics, and Clinical Outcomes.

Author

Green, Sabrina, Clark, Justin, Santos, Haroldo, Weesner, Kyle, Salazar, Keiko, Aslam, Saima, Campbell, J, Blodget, Emily, Morris, Michele, Suh, Gina, Obeid, Karam, Silveira, Fernanda, Filippov, Andrey, Whiteson, Katrine, Trautner, Barbara, Terwilliger, Austen, Maresso, Anthony, and Doernberg, Sarah

Subjects
antibiotic resistance, microbiology, phage, phage therapy, Humans, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Bacteriophages, Phage Therapy, Retrospective Studies
Abstract

BACKGROUND: Antimicrobial resistance (AMR) is undermining modern medicine, a problem compounded by bacterial adaptation to antibiotic pressures. Phages are viruses that infect bacteria. Their diversity and evolvability offer the prospect of their use as a therapeutic solution. Reported are outcomes of customized phage therapy for patients with difficult-to-treat antimicrobial resistant infections. METHODS: We retrospectively assessed 12 cases of customized phage therapy from a phage production center. Phages were screened, purified, sequenced, characterized, and Food and Drug Administration-approved via the IND (investigational new drug) compassionate-care route. Outcomes were assessed as favorable or unfavorable by microbiologic and clinical standards. Infections were device-related or systemic. Other experiences such as time to treatment, antibiotic synergy, and immune responses were recorded. RESULTS: Fifty requests for phage therapy were received. Customized phages were generated for 12 patients. After treatment, 42% (5/12) of cases showed bacterial eradication and 58% (7/12) showed clinical improvement, with two-thirds of all cases (66%) showing favorable responses. No major adverse reactions were observed. Antibiotic-phage synergy in vitro was observed in most cases. Immunological neutralization of phages was reported in 5 cases. Several cases were complicated by secondary infections. Complete characterization of the phages (morphology, genomics, and activity) and their production (methods, sterility, and endotoxin tests) are reported. CONCLUSIONS: Customized phage production and therapy was safe and yielded favorable clinical or microbiological outcomes in two-thirds of cases. A center or pipeline dedicated to tailoring the phages against a patients specific AMR bacterial infection may be a viable option where standard treatment has failed.

Published
2023

16. Discovery of a filamentary synchrotron structure connected to the coherent magnetic field in the outer Galaxy

Author

West, J. L., Campbell, J. L., Bhaura, P., Kothes, R., Safi-Harb, S., Stil, J. M., Taylor, A. R., Foster, T., Gaensler, B. M., George, S. J., Gibson, S. J., and Ricci, R.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Using data from the Galactic Arecibo L-band Feed Array Continuum Transit Survey (GALFACTS), we report the discovery of two previously unidentified, very compressed, thin, and straight polarized filaments approximately centred at Galactic coordinates, $(l,b)=(182.5^\circ,-4.0^\circ)$, which we call G182.5--4.0. Using data from the Isaac Newton Telescope Galactic Plane Survey (IGAPS), we also find straight, long, and extremely thin H$\alpha$ filaments coincident with the radio emission. These filaments are positioned in projection at the edge of the Orion-Eridanus superbubble and we find evidence indicating that the filaments align with the coherent magnetic field of the outer Galaxy. We find a lower limit on the total radio flux at 1.4~GHz to be $0.7\pm0.3$~Jy with an average linearly polarized fraction of $40\substack{+30 \\ -20}\%$. We consider various scenarios that could explain the origin of these filaments, including a shell-type supernova remnant (SNR), a bow shock nebula associated with a pulsar, or relic fragments from one or more supernova explosions in the adjacent superbubble, with a hybrid scenario being most likely. This may represent an example of a new class of objects that is neither an SNR nor a bow shock. The highly compressed nature of these filaments and their alignment with Galactic plane suggests a scenario where this object formed in a magnetic field that was compressed by the expanding Orion-Eridanus superbubble, suggesting that the object is related to this superbubble and implying a distance of $\sim$400~pc., Comment: 17 pages, 9 figures, accepted to Astrophysical Journal

Published
2022
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20. Precision QCD, Hadronic Structure & Forward QCD, Heavy Ions: Report of Energy Frontier Topical Groups 5, 6, 7 submitted to Snowmass 2021

Author

Begel, M., Hoeche, S., Schmitt, M., Lin, H. -W., Nadolsky, P. M., Royon, C., Lee, Y-J., Mukherjee, S., Baldenegro, C., Campbell, J., Chachamis, G., Celiberto, F. G., Cooper-Sarkar, A. M., d'Enterria, D., Diefenthaler, M., Fucilla, M., Garzelli, M. V., Guzzi, M., Hentschinski, M., Hobbs, T. J., Huston, J., Isaacson, J., Klein, S. R., Kling, F., Kotko, P., Kovchegov, Yu. V., Krintiras, G., Kronfeld, A. S., Kutak, K., Mistlberger, B., Moult, I., Mrenna, S., Nachman, B., Narain, M., Olness, F. I., Papa, A., Pisarski, R. D., Pitt, M., Rappoccio, S., Reina, L., Reuter, J., Reno, M. H., Salam, G. P., Strikman, M., Tran, N., Tricoli, A., Ubiali, M., van Hameren, A., Vossen, A., and Xie, K.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, High Energy Physics - Lattice, Nuclear Experiment, Nuclear Theory
Abstract

This report was prepared on behalf of three Energy Frontier Topical Groups of the Snowmass 2021 Community Planning Exercise. It summarizes the status and implications of studies of strong interactions in high-energy experiments and QCD theory. We emphasize the rich landscape and broad impact of these studies in the decade ahead. Hadronic interactions play a central role in the high-luminosity Large Hadron Collider (LHC) physics program, and strong synergies exist between the (HL-)LHC and planned or proposed experiments at the U.S. Electron-Ion Collider, CERN forward physics experiments, high-intensity facilities, and future TeV-range lepton and hadron colliders. Prospects for precision determinations of the strong coupling and a variety of nonperturbative distribution and fragmentation functions are examined. We also review the potential of envisioned tests of new dynamical regimes of QCD in high-energy and high-density scattering processes with nucleon, ion, and photon initial states. The important role of the high-energy heavy-ion program in studies of nuclear structure and the nuclear medium, and its connections with QCD involving nucleons are summarized. We address ongoing and future theoretical advancements in multi-loop QCD computations, lattice QCD, jet substructure, and event generators. Cross-cutting connections between experimental measurements, theoretical predictions, large-scale data analysis, and high-performance computing are emphasized., Comment: 95 pages (bibliography 30 pages), 28 figures; v.2: minor changes, authors and references added

Published
2022

21. Variability in Plus Disease Diagnosis using Single and Serial Images

Author

Cole, Emily D, Park, Shin Hae, Kim, Sang Jin, Kang, Kai B, Valikodath, Nita G, Al-Khaled, Tala, Patel, Samir N, Jonas, Karyn E, Ostmo, Susan, Coyner, Aaron, Berrocal, Audina, Drenser, Kimberly A, Nagiel, Aaron, Horowitz, Jason D, Lee, Thomas C, Kalpathy-Cramer, Jayashree, Chiang, Michael F, Campbell, J Peter, Chan, RV Paul, Consortium, Imaging and Informatics in Retinopathy of Prematurity Research, Sonmez, Kemal, Jonas, Karyn, Horowitz, Jason, Coki, Osode, Eccles, Cheryl-Ann, Sarna, Leora, Orlin, Anton, Negron, Catherin, Denser, Kimberly, Cumming, Kristi, Osentoski, Tammy, Check, Tammy, Zajechowski, Mary, Lee, Thomas, Kruger, Evan, McGovern, Kathryn, Simmons, Charles, Murthy, Raghu, Galvis, Sharon, Rotter, Jerome, Chen, Ida, Li, Xiaohui, Taylor, Kent, Roll, Kaye, Erdogmus, Deniz, Ioannidis, Stratis, Martinez-Castellanos, Maria Ana, Salinas-Longoria, Samantha, Romero, Rafael, Arriola, Andrea, Olguin-Manriquez, Francisco, Meraz-Gutierrez, Miroslava, Dulanto-Reinoso, Carlos M, and Montero-Mendoza, Cristina

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Research, Pediatric, Eye Disease and Disorders of Vision, Perinatal Period - Conditions Originating in Perinatal Period, Rare Diseases, Eye, Infant, Newborn, Humans, Retinopathy of Prematurity, Cohort Studies, Reproducibility of Results, Diagnostic Imaging, Telemedicine, Retinopathy of prematurity, ROP imaging, ROP progression, ROP screening, telemedicine, Imaging and Informatics in Retinopathy of Prematurity (i-ROP) Research Consortium, Ophthalmology and optometry
Abstract

PurposeTo assess changes in retinopathy of prematurity (ROP) diagnosis in single and serial retinal images.DesignCohort study.ParticipantsCases of ROP recruited from the Imaging and Informatics in Retinopathy of Prematurity (i-ROP) consortium evaluated by 7 graders.MethodsSeven ophthalmologists reviewed both single and 3 consecutive serial retinal images from 15 cases with ROP, and severity was assigned as plus, preplus, or none. Imaging data were acquired during routine ROP screening from 2011 to 2015, and a reference standard diagnosis was established for each image. A secondary analysis was performed using the i-ROP deep learning system to assign a vascular severity score (VSS) to each image, ranging from 1 to 9, with 9 being the most severe disease. This score has been previously demonstrated to correlate with the International Classification of ROP. Mean plus disease severity was calculated by averaging 14 labels per image in serial and single images to decrease noise.Main outcome measuresGrading severity of ROP as defined by plus, preplus, or no ROP.ResultsAssessment of serial retinal images changed the grading severity for > 50% of the graders, although there was wide variability. Cohen's kappa ranged from 0.29 to 1.0, which showed a wide range of agreement from slight to perfect by each grader. Changes in the grading of serial retinal images were noted more commonly in cases of preplus disease. The mean severity in cases with a diagnosis of plus disease and no disease did not change between single and serial images. The ROP VSS demonstrated good correlation with the range of expert classifications of plus disease and overall agreement with the mode class (P = 0.001). The VSS correlated with mean plus disease severity by expert diagnosis (correlation coefficient, 0.89). The more aggressive graders tended to be influenced by serial images to increase the severity of their grading. The VSS also demonstrated agreement with disease progression across serial images, which progressed to preplus and plus disease.ConclusionsClinicians demonstrated variability in ROP diagnosis when presented with both single and serial images. The use of deep learning as a quantitative assessment of plus disease has the potential to standardize ROP diagnosis and treatment.

Published
2022

24. Event Generators for High-Energy Physics Experiments

Author

Campbell, J. M., Diefenthaler, M., Hobbs, T. J., Höche, S., Isaacson, J., Kling, F., Mrenna, S., Reuter, J., Alioli, S., Andersen, J. R., Andreopoulos, C., Ankowski, A. M., Aschenauer, E. C., Ashkenazi, A., Baker, M. D., Barrow, J. L., van Beekveld, M., Bewick, G., Bhattacharya, S., Bierlich, C., Bothmann, E., Bredt, P., Broggio, A., Buckley, A., Butter, A., Butterworth, J. M., Byrne, E. P., Calame, C. M. Carloni, Chakraborty, S., Chen, X., Chiesa, M., Childers, J. T., Cruz-Martinez, J., Currie, J., Darvishi, N., Dasgupta, M., Denner, A., Dreyer, F. A., Dytman, S., El-Menoufi, B. K., Engel, T., Ravasio, S. Ferrario, Figueroa, D., Flower, L., Forshaw, J. R., Frederix, R., Friedland, A., Frixione, S., Gallagher, H., Gallmeister, K., Gardiner, S., Gauld, R., Gaunt, J., Gavardi, A., Gehrmann, T., Ridder, A. Gehrmann-De, Gellersen, L., Giele, W., Gieseke, S., Giuli, F., Glover, E. W. N., Grazzini, M., Grohsjean, A., Gütschow, C., Hamilton, K., Han, T., Hatcher, R., Heinrich, G., Helenius, I., Hen, O., Hirschi, V., Höfer, M., Holguin, J., Huss, A., Ilten, P., Jadach, S., Jentsch, A., Jones, S. P., Ju, W., Kallweit, S., Karlberg, A., Katori, T., Kerner, M., Kilian, W., Kirchgaeßer, M. M., Klein, S., Knobbe, M., Krause, C., Krauss, F., Lang, J., Lang, J. -N., Lee, G., Li, S. W., Lim, M. A., Lindert, J. M., Lombardi, D., Lönnblad, L., Löschner, M., Lurkin, N., Ma, Y., Machado, P., Magerya, V., Maier, A., Majer, I., Maltoni, F., Marcoli, M., Marinelli, G., Masouminia, M. R., Mastrolia, P., Mattelaer, O., Mazzitelli, J., McFayden, J., Medves, R., Meinzinger, P., Mo, J., Monni, P. F., Montagna, G., Morgan, T., Mosel, U., Nachman, B., Nadolsky, P., Nagar, R., Nagy, Z., Napoletano, D., Nason, P., Neumann, T., Nevay, L. J., Nicrosini, O., Niehues, J., Niewczas, K., Ohl, T., Ossola, G., Pandey, V., Papadopoulou, A., Papaefstathiou, A., Paz, G., Pellen, M., Pelliccioli, G., Peraro, T., Piccinini, F., Pickering, L., Pires, J., Płaczek, W., Plätzer, S., Plehn, T., Pozzorini, S., Prestel, S., Preuss, C. T., Price, A. C., Quackenbush, S., Re, E., Reichelt, D., Reina, L., Reuschle, C., Richardson, P., Rocco, M., Rocco, N., Roda, M., Garcia, A. Rodriguez, Roiser, S., Rojo, J., Rottoli, L., Salam, G. P., Schönherr, M., Schuchmann, S., Schumann, S., Schürmann, R., Scyboz, L., Seymour, M. H., Siegert, F., Signer, A., Chahal, G. Singh, Siódmok, A., Sjöstrand, T., Skands, P., Smillie, J. M., Sobczyk, J. T., Soldin, D., Soper, D. E., Soto-Ontoso, A., Soyez, G., Stagnitto, G., Tena-Vidal, J., Tomalak, O., Tramontano, F., Trojanowski, S., Tu, Z., Uccirati, S., Ullrich, T., Ulrich, Y., Utheim, M., Valassi, A., Verbytskyi, A., Verheyen, R., Wagman, M., Walker, D., Webber, B. R., Weinstein, L., White, O., Whitehead, J., Wiesemann, M., Wilkinson, C., Williams, C., Winterhalder, R., Wret, C., Xie, K., Yang, T-Z., Yazgan, E., Zanderighi, G., Zanoli, S., and Zapp, K.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments., Comment: 164 pages, 10 figures, contribution to Snowmass 2021

Published
2022

25. Deeply virtual Compton scattering cross section at high Bjorken $x_B$

Author

Georges, F., Rashad, M. N. H., Stefanko, A., Dlamini, M., Karki, B., Ali, S. F., Lin, P-J., Ko, H-S, Israel, N., Adikaram, D., Ahmed, Z., Albataineh, H., Aljawrneh, B., Allada, K., Allison, S., Alsalmi, S., Androic, D., Aniol, K., Annand, J., Atac, H., Averett, T., Gayoso, C. Ayerbe, Bai, X., Bane, J., Barcus, S., Bartlett, K., Bellini, V., Beminiwattha, R., Bericic, J., Biswas, D., Brash, E., Bulumulla, D., Campbell, J., Camsonne, A., Carmignotto, M., Castellano, J., Chen, C., Chen, J-P., Chetry, T., Christy, M. E., Cisbani, E., Clary, B., Cohen, E., Compton, N., Cornejo, J. C., Dusa, S. Covrig, Crowe, B., Danagoulian, S., Danley, T., De Persio, F., Deconinck, W., Defurne, M., Desnault, C., Di, D., Duer, M., Duran, B., Ent, R., Fanelli, C., Franklin, G., Fuchey, E., Gal, C., Gaskell, D., Gautam, T., Glamazdin, O., Gnanvo, K., Gray, V. M., Gu, C., Hague, T., Hamad, G., Hamilton, D., Hamilton, K., Hansen, O., Hauenstein, F., Henry, W., Higinbotham, D. W., Holmstrom, T., Horn, T., Huang, Y., Huber, G. M., Hyde, C., Ibrahim, H., Jen, C-M., Jin, K., Jones, M., Kabir, A., Keppel, C., Khachatryan, V., King, P. M., Li, S., Li, W. B., Liu, J., Liu, H., Liyanage, A., Magee, J., Malace, S., Mammei, J., Markowitz, P., McClellan, E., Mazouz, M., Meddi, F., Meekins, D., Mesik, K., Michaels, R., Mkrtchyan, A., Montgomery, R., Camacho, C. Muñoz, Myers, L. S., Nadel-Turonski, P., Nazeer, S. J., Nelyubin, V., Nguyen, D., Nuruzzaman, N., Nycz, M., Obretch, O. F., Ou, L., Palatchi, C., Pandey, B., Park, S., Park, K., Peng, C., Pomatsalyuk, R., Pooser, E., Puckett, A. J. R., Punjabi, V., Quinn, B., Rahman, S., Reimer, P. E., Roche, J., Sapkota, I., Sarty, A., Sawatzky, B., Saylor, N. H., Schmookler, B., Shabestari, M. H., Shahinyan, A., Sirca, S., Smith, G. R., Sooriyaarachchilage, S., Sparveris, N., Spies, R., Su, T., Subedi, A., Sulkosky, V., Sun, A., Thorne, L., Tian, Y., Ton, N., Tortorici, F., Trotta, R., Urciuoli, G. M., Voutier, E., Waidyawansa, B., Wang, Y., Wojtsekhowski, B., Wood, S., Yan, X., Ye, L., Ye, Z., Yero, C., Zhang, J., Zhao, Y., and Zhu, P.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Experiment
Abstract

We report high-precision measurements of the Deeply Virtual Compton Scattering (DVCS) cross section at high values of the Bjorken variable $x_B$. DVCS is sensitive to the Generalized Parton Distributions of the nucleon, which provide a three-dimensional description of its internal constituents. Using the exact analytic expression of the DVCS cross section for all possible polarization states of the initial and final electron and nucleon, and final state photon, we present the first experimental extraction of all four helicity-conserving Compton Form Factors (CFFs) of the nucleon as a function of $x_B$, while systematically including helicity flip amplitudes. In particular, the high accuracy of the present data demonstrates sensitivity to some very poorly known CFFs.

Published
2022
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27. An Analysis of Solicitations From Predatory Journals in Ophthalmology

Author

Justin, Grant A., Huang, Charles, Nguyen, Michael K., Lee, Jessica, Seddon, Ian, Wesley, Treven A., Bakri, Sophie J., Peter Campbell, J., Cavuoto, Kara, Collins, Megan, Gedde, Steven J., Kossler, Andrea L., Milman, Tatyana, Shukla, Aakriti, Sridhar, Jayanth, Syed, Zeba A., Williams, Jr. Basil K., Woreta, Fasika A., Patel, Samir N., and Yonekawa, Yoshihiro

Published
2024
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29. A Comparison of Multi-Phase Magnetic Field Tracers in a High-Galactic Latitude Region of the Filamentary Interstellar Medium

Author

Campbell, J. L., Clark, S. E., Gaensler, B. M., Marchal, A., Van Eck, C. L., Deshpande, A. A., George, S. J., Gibson, S. J., Ricci, R., Stil, J. M., and Taylor, A. R.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Understanding how the Galactic magnetic field threads the multi-phase interstellar medium (ISM) remains a considerable challenge, as different magnetic field tracers probe dissimilar phases and field components. We search for evidence of a common magnetic field shared between the ionized and neutral ISM by comparing 1.4 GHz radio continuum polarization and HI line emission from the Galactic Arecibo L-Band Feed Array Continuum Transit Survey (GALFACTS) and Galactic Arecibo L-Band Feed Array HI (GALFA-HI) survey, respectively. We compute the polarization gradient of the continuum emission and search for associations with diffuse/translucent HI structures. The polarization gradient is sensitive to changes in the integrated product of the thermal electron density and line-of-sight field strength ($B_\parallel$) in warm ionized gas, while narrow HI structures highlight the plane-of-sky field orientation in cold neutral gas. We identified one region in the high-Galactic latitude Arecibo sky, G216+26 centered on $(\ell,b)\sim(216\deg,+26\deg)$, containing filaments in the polarization gradient that are aligned with narrow HI structures roughly parallel to the Galactic plane. We present a comparison of multi-phase observations and magnetic field tracers of this region, demonstrating that the warm ionized and cold neutral media are connected likely via a common magnetic field. We quantify the physical properties of a polarization gradient filament associated with H$\alpha$ emission, measuring a line-of-sight field strength $B_\parallel=6{\pm}4 \mu$G and a plasma beta $\beta=2.1^{+3.1}_{-2.1}$. We discuss the lack of widespread multi-phase magnetic field alignments and consider whether this region is associated with a short-timescale or physically rare phenomenon. This work highlights the utility of multi-tracer analyses for understanding the magnetized ISM., Comment: 30 pages, 17 figures, minor edits to reflect published version

Published
2021
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30. Image-Based Differentiation of Bacterial and Fungal Keratitis Using Deep Convolutional Neural Networks.

Author

Redd, Travis K, Prajna, N Venkatesh, Srinivasan, Muthiah, Lalitha, Prajna, Krishnan, Tiru, Rajaraman, Revathi, Venugopal, Anitha, Acharya, Nisha, Seitzman, Gerami D, Lietman, Thomas M, Keenan, Jeremy D, Campbell, J Peter, and Song, Xubo

Subjects
AUC, area under the receiver operating characteristic curve, Artificial intelligence, Bacterial keratitis, CI, confidence interval, CNN, convolutional neural network, Computer vision, Convolutional neural networks, Corneal ulcer, Deep learning, Fungal keratitis, Infectious keratitis, MUTT, Mycotic Ulcer Treatment Trials, SCUT, Steroids for Corneal Ulcers Trial, Clinical Research, Eye Disease and Disorders of Vision, Good Health and Well Being
Abstract

PurposeDevelop computer vision models for image-based differentiation of bacterial and fungal corneal ulcers and compare their performance against human experts.DesignCross-sectional comparison of diagnostic performance.ParticipantsPatients with acute, culture-proven bacterial or fungal keratitis from 4 centers in South India.MethodsFive convolutional neural networks (CNNs) were trained using images from handheld cameras collected from patients with culture-proven corneal ulcers in South India recruited as part of clinical trials conducted between 2006 and 2015. Their performance was evaluated on 2 hold-out test sets (1 single center and 1 multicenter) from South India. Twelve local expert cornea specialists performed remote interpretation of the images in the multicenter test set to enable direct comparison against CNN performance.Main outcome measuresArea under the receiver operating characteristic curve (AUC) individually and for each group collectively (i.e., CNN ensemble and human ensemble).ResultsThe best-performing CNN architecture was MobileNet, which attained an AUC of 0.86 on the single-center test set (other CNNs range, 0.68-0.84) and 0.83 on the multicenter test set (other CNNs range, 0.75-0.83). Expert human AUCs on the multicenter test set ranged from 0.42 to 0.79. The CNN ensemble achieved a statistically significantly higher AUC (0.84) than the human ensemble (0.76; P < 0.01). CNNs showed relatively higher accuracy for fungal (81%) versus bacterial (75%) ulcers, whereas humans showed relatively higher accuracy for bacterial (88%) versus fungal (56%) ulcers. An ensemble of the best-performing CNN and best-performing human achieved the highest AUC of 0.87, although this was not statistically significantly higher than the best CNN (0.83; P = 0.17) or best human (0.79; P = 0.09).ConclusionsComputer vision models achieved superhuman performance in identifying the underlying infectious cause of corneal ulcers compared with cornea specialists. The best-performing model, MobileNet, attained an AUC of 0.83 to 0.86 without any additional clinical or historical information. These findings suggest the potential for future implementation of these models to enable earlier directed antimicrobial therapy in the management of infectious keratitis, which may improve visual outcomes. Additional studies are ongoing to incorporate clinical history and expert opinion into predictive models.

Published
2022

31. Deeply Virtual Compton Scattering Cross Section at High Bjorken x_{B}.

Author

Georges, F, Rashad, MNH, Stefanko, A, Dlamini, M, Karki, B, Ali, SF, Lin, P-J, Ko, H-S, Israel, N, Adikaram, D, Ahmed, Z, Albataineh, H, Aljawrneh, B, Allada, K, Allison, S, Alsalmi, S, Androic, D, Aniol, K, Annand, J, Atac, H, Averett, T, Ayerbe Gayoso, C, Bai, X, Bane, J, Barcus, S, Bartlett, K, Bellini, V, Beminiwattha, R, Bericic, J, Biswas, D, Brash, E, Bulumulla, D, Campbell, J, Camsonne, A, Carmignotto, M, Castellano, J, Chen, C, Chen, J-P, Chetry, T, Christy, ME, Cisbani, E, Clary, B, Cohen, E, Compton, N, Cornejo, JC, Covrig Dusa, S, Crowe, B, Danagoulian, S, Danley, T, De Persio, F, Deconinck, W, Defurne, M, Desnault, C, Di, D, Duer, M, Duran, B, Ent, R, Fanelli, C, Franklin, G, Fuchey, E, Gal, C, Gaskell, D, Gautam, T, Glamazdin, O, Gnanvo, K, Gray, VM, Gu, C, Hague, T, Hamad, G, Hamilton, D, Hamilton, K, Hansen, O, Hauenstein, F, Henry, W, Higinbotham, DW, Holmstrom, T, Horn, T, Huang, Y, Huber, GM, Hyde, CE, Ibrahim, H, Jen, C-M, Jin, K, Jones, M, Kabir, A, Keppel, C, Khachatryan, V, King, PM, Li, S, Li, WB, Liu, J, Liu, H, Liyanage, A, Magee, J, Malace, S, Mammei, J, Markowitz, P, McClellan, E, Mazouz, M, and Meddi, F

Subjects
Jefferson Lab Hall A Collaboration, Mathematical Sciences, Physical Sciences, Engineering, General Physics
Abstract

We report high-precision measurements of the deeply virtual Compton scattering (DVCS) cross section at high values of the Bjorken variable x_{B}. DVCS is sensitive to the generalized parton distributions of the nucleon, which provide a three-dimensional description of its internal constituents. Using the exact analytic expression of the DVCS cross section for all possible polarization states of the initial and final electron and nucleon, and final state photon, we present the first experimental extraction of all four helicity-conserving Compton form factors (CFFs) of the nucleon as a function of x_{B}, while systematically including helicity flip amplitudes. In particular, the high accuracy of the present data demonstrates sensitivity to some very poorly known CFFs.

Published
2022

34. Not Color Blind: AI Predicts Racial Identity from Black and White Retinal Vessel Segmentations

Author

Coyner, Aaron S., Singh, Praveer, Brown, James M., Ostmo, Susan, Chan, R. V. Paul, Chiang, Michael F., Kalpathy-Cramer, Jayashree, and Campbell, J. Peter

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Background: Artificial intelligence (AI) may demonstrate racial bias when skin or choroidal pigmentation is present in medical images. Recent studies have shown that convolutional neural networks (CNNs) can predict race from images that were not previously thought to contain race-specific features. We evaluate whether grayscale retinal vessel maps (RVMs) of patients screened for retinopathy of prematurity (ROP) contain race-specific features. Methods: 4095 retinal fundus images (RFIs) were collected from 245 Black and White infants. A U-Net generated RVMs from RFIs, which were subsequently thresholded, binarized, or skeletonized. To determine whether RVM differences between Black and White eyes were physiological, CNNs were trained to predict race from color RFIs, raw RVMs, and thresholded, binarized, or skeletonized RVMs. Area under the precision-recall curve (AUC-PR) was evaluated. Findings: CNNs predicted race from RFIs near perfectly (image-level AUC-PR: 0.999, subject-level AUC-PR: 1.000). Raw RVMs were almost as informative as color RFIs (image-level AUC-PR: 0.938, subject-level AUC-PR: 0.995). Ultimately, CNNs were able to detect whether RFIs or RVMs were from Black or White babies, regardless of whether images contained color, vessel segmentation brightness differences were nullified, or vessel segmentation widths were normalized. Interpretation: AI can detect race from grayscale RVMs that were not thought to contain racial information. Two potential explanations for these findings are that: retinal vessels physiologically differ between Black and White babies or the U-Net segments the retinal vasculature differently for various fundus pigmentations. Either way, the implications remain the same: AI algorithms have potential to demonstrate racial bias in practice, even when preliminary attempts to remove such information from the underlying images appear to be successful., Comment: 31 pages, 6 figures

Published
2021

35. Characterization of Muon and Electron Beams in the Paul Scherrer Institute PiM1 Channel for the MUSE Experiment

Author

Cline, E., Lin, W., Roy, P., Reimer, P. E., Mesick, K. E., Akmal, A., Alie, A., Atac, H., Atencio, A., Gayoso, C. Ayerbe, Benmouna, N., Benmokhtar, F., Bernauer, J. C., Briscoe, W. J., Campbell, J., Cohen, D., Cohen, E. O., Collicott, C., Deiters, K., Dogra, S., Downie, E., Fernando, I. P., Flannery, A., Gautam, T., Ghosal, D., Gilman, R., Golossanov, A., Halter, B. F., Hirschman, J., Ilieva, Y., Kim, M., Kohl, M., Krusche, B., Lavrukhin, I., Li, L., Liang-Gilman, B., Liyanage, A., Lorenzon, W., Mohanmurthy, P., Mokal, R., Moran, P., Nazeer, S. J., Or, P., Patel, T., Piasetzky, E., Rauber, T., Raymond, R. S., Reggiani, D., Reid, H., Ron, G., Rooney, E., Rostomyan, T., Schwarz, M., Sneath, A., Solazzo, P. G., Sparveris, N., Steinberg, N., Strauch, S., Sulkosky, V., and Wuerfel, N.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The MUon Scattering Experiment, MUSE, at the Paul Scherrer Institute, Switzerland, investigates the proton charge radius puzzle, lepton universality, and two-photon exchange, via simultaneous measurements of elastic muon-proton and electron-proton scattering. The experiment uses the PiM1 secondary beam channel, which was designed for high precision pion scattering measurements. We review the properties of the beam line established for pions. We discuss the production processes that generate the electron and muon beams, and the simulations of these processes. Simulations of the $\pi$/$\mu$/$e$ beams through the channel using TURTLE and G4beamline are compared. The G4beamline simulation is then compared to several experimental measurements of the channel, including the momentum dispersion at the IFP and target, the shape of the beam spot at the target, and timing measurements that allow the beam momenta to be determined. We conclude that the PiM1 channel can be used for high precision $\pi$, $\mu$, and $e$ scattering., Comment: 20 pages, 18 figures

Published
2021
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41. The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM)

Author

Walklin, C. G, Young, Hannah M.L, Asghari, E, Bhandari, S, Billany, R. E, Bishop, N, Bramham, K, Briggs, J, Burton, J. O., Campbell, J, Castle, E. M, Chilcot, J, Cooper, N, Deelchand, V, Graham-Brown, M. P.M, Hamilton, A, Jesky, M, Kalra, P. A, Koufaki, P, McCafferty, K, Nixon, A. C, Noble, H, Saynor, Z. L., Sothinathan, C, Taal, M. W, Tollitt, J, Wheeler, D.C, Wilkinson, T. J, Macdonald, J.H, and Greenwood, S. A

Published
2023
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42. Form Factors and Two-Photon Exchange in High-Energy Elastic Electron-Proton Scattering

Author

Christy, ME, Gautam, T, Ou, L, Schmookler, B, Wang, Y, Adikaram, D, Ahmed, Z, Albataineh, H, Ali, SF, Aljawrneh, B, Allada, K, Allison, SL, Alsalmi, S, Androic, D, Aniol, K, Annand, J, Arrington, J, Atac, H, Averett, T, Gayoso, C Ayerbe, Bai, X, Bane, J, Barcus, S, Bartlett, K, Bellini, V, Beminiwattha, R, Bericic, J, Bhatt, H, Bhetuwal, D, Biswas, D, Brash, E, Bulumulla, D, Camacho, CM, Campbell, J, Camsonne, A, Carmignotto, M, Castellanos, J, Chen, C, Chen, J-P, Chetry, T, Cisbani, E, Clary, B, Cohen, E, Compton, N, Cornejo, JC, Dusa, S Covrig, Crowe, B, Danagoulian, S, Danley, T, Deconinck, W, Defurne, M, Desnault, C, Di, D, Dlamini, M, Duer, M, Duran, B, Ent, R, Fanelli, C, Fuchey, E, Gal, C, Gaskell, D, Georges, F, Gilad, S, Glamazdin, O, Gnanvo, K, Gramolin, AV, Gray, VM, Gu, C, Habarakada, A, Hague, T, Hamad, G, Hamilton, D, Hamilton, K, Hansen, O, Hauenstein, F, Hernandez, AV, Henry, W, Higinbotham, DW, Holmstrom, T, Horn, T, Huang, Y, Huber, GM, Hyde, C, Ibrahim, H, Israel, N, Jen, C-M, Jin, K, Jones, M, Kabir, A, Karki, B, Keppel, C, Khachatryan, V, King, PM, Li, S, Li, W, Liu, H, Liu, J, Liyanage, AH, Mack, D, and Magee, J

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract

We present new precision measurements of the elastic electron-proton scattering cross section for momentum transfer (Q^{2}) up to 15.75  (GeV/c)^{2}. Combined with existing data, these provide an improved extraction of the proton magnetic form factor at high Q^{2} and double the range over which a longitudinal or transverse separation of the cross section can be performed. The difference between our results and polarization data agrees with that observed at lower Q^{2} and attributed to hard two-photon exchange (TPE) effects, extending to 8  (GeV/c)^{2} the range of Q^{2} for which a discrepancy is established at >95% confidence. We use the discrepancy to quantify the size of TPE contributions needed to explain the cross section at high Q^{2}.

Published
2022

43. Expert Performance in Visual Differentiation of Bacterial and Fungal Keratitis

Author

Redd, Travis K, Prajna, N Venkatesh, Srinivasan, Muthiah, Lalitha, Prajna, Krishnan, Tiru, Rajaraman, Revathi, Venugopal, Anitha, Lujan, Brandon, Acharya, Nisha, Seitzman, Gerami D, Rose-Nussbaumer, Jennifer, Lietman, Thomas M, Campbell, J Peter, Keenan, Jeremy D, Group, Corneal Ulcer Image Interpretation Study, Alvarez-Melloni, Diana, Ayalew, Menen, Balasubramanian, Ashwin, Chan, Elsie, Chan, Matilda, Chaudhary, Meenu, Chia, Thomas, Chodosh, James, Choong, YY, Christenbury, Joseph, Christy, Josephine, Clements, John, Dart, John, Dastjerdi, Mohammad, Denny, Matthew, Devarajan, Sathish, Elghobaier, Mohamed, Estopinal, Chris, Gandhi, Preethika, Gokhale, Nikhil, Halfpenny, Colleen, Hazarbassanov, Rossen, Hernandez, Natalie, Hovakimyan, Anna, Hwang, David, Hwang, Frank, Jaeschke, Tomas, Jhanji, Vishal, Karas, Faris, Karthik, Divya, Kase, Camila, Kattana, Lakshmi, Kim, Tyson, Koreishi, Aaleya, Liang, David, Martinez, Christine, Martinez-Costa, Rafael, McLeod, Stephen, Mehta, Jodhbir S, Mimouni, Michael, Moss, Adam, Nanji, Afshan, Nataneli, Nathan, Panday, Vasudha, Pradhan, Sayali, Qian, Ying, Rao, Naveen, Schallhorn, Julie, Sella, Ruti, Selvaraj, Suvitha, Spokes, David, Shaik, Neha, Shekhawat, Nakul, Sugar, Alan, Rostov, Audrey Talley, Tananuvat, Napaporn, Tangmonkongvoragul, Chulaluck, Trinh, Tanya, Tuli, Sonal, Upaphong, Phit, van Dooren, Bart, Vasudevan, Manoj, Viriya, Elizabeth, and Woodward, Maria

Subjects
Area Under Curve, Bacteria, Cornea, Corneal Ulcer, Diagnosis, Differential, Diagnostic Techniques, Ophthalmological, Expert Systems, Eye Infections, Bacterial, Eye Infections, Fungal, Fungi, Humans, ROC Curve, Specialization, Bacterial keratitis, Corneal ulcer, Fungal keratitis, Infectious keratitis, Corneal Ulcer Image Interpretation Study Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

This study quantifies the performance of an international cohort of cornea specialists in image-based differentiation of bacterial and fungal keratitis, identifying significant regional variation and establishing a reference standard for comparison against machine learning models.

Published
2022

44. The Global Magneto-Ionic Medium Survey (GMIMS): The brightest polarized region in the Southern sky at 75cm and its implications for Radio Loop II

Author

Thomson, Alec J. M., Landecker, T. L., McClure-Griffiths, N. M., Dickey, John M., Campbell, J. L., Carretti, Ettore, Clark, S. E., Federrath, Christoph, Gaensler, B. M., Han, J. L., Haverkorn, Marijke, Hill, Alex. S., Mao, S. A., Ordog, Anna, Pratley, Luke, Reich, Wolfgang, Van Eck, Cameron L., West, J. L., and Wolleben, M.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Using the Global Magneto-Ionic Medium Survey (GMIMS) Low-Band South (LBS) southern sky polarization survey, covering 300 to 480 MHz at 81 arcmin resolution, we reveal the brightest region in the Southern polarized sky at these frequencies. The region, G150-50, covers nearly 20deg$^2$, near (l,b)~(150 deg,-50 deg). Using GMIMS-LBS and complementary data at higher frequencies (~0.6--30 GHz), we apply Faraday tomography and Stokes QU-fitting techniques. We find that the magnetic field associated with G150-50 is both coherent and primarily in the plane of the sky, and indications that the region is associated with Radio Loop II. The Faraday depth spectra across G150-50 are broad and contain a large-scale spatial gradient. We model the magnetic field in the region as an expanding shell, and we can reproduce both the observed Faraday rotation and the synchrotron emission in the GMIMS-LBS band. Using QU-fitting, we find that the Faraday spectra are produced by several Faraday dispersive sources along the line-of-sight. Alternatively, polarization horizon effects that we cannot model are adding complexity to the high-frequency polarized spectra. The magnetic field structure of Loop II dominates a large fraction of the sky, and studies of the large-scale polarized sky will need to account for this object. Studies of G150-50 with high angular resolution could mitigate polarization horizon effects, and clarify the nature of G150-50., Comment: 25 pages, 14 figures. Accepted for publication in MNRAS

Published
2021
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47. An assessment of methods used for the generation and characterization of cryomilled polystyrene micro- and nanoplastic particles

Author

Campbell J. McColley, Jeffrey A. Nason, Bryan J. Harper, and Stacey L. Harper

Subjects
Microplastics, Nanoplastics, Cryomilling, Particle sizing, Polystyrene, Environmental pollution, TD172-193.5, Polymers and polymer manufacture, TP1080-1185
Abstract

Abstract There is a critical need to generate environmentally relevant microplastics (MPs) and nanoplastics (NPs) to better investigate their behavior in laboratory settings. Environmental MPs are heterogenous in size and shape, unlike monodisperse and uniform microspheres commonly used as surrogates. Cryogenic grinding, or cryomilling, was successfully utilized to transform polystyrene (PS) bulk material into heterogenous micro and nano fragments. Fourier-Transform Infrared (FTIR) spectroscopy confirmed that this approach did not alter polymer surface chemistry. The number of milling cycles (time of milling) and frequency of grinding (intensity of milling) were varied to investigate the role cryomilling parameters had on generated MP characteristics. The resulting particle size distributions of cryomilled samples were measured and compared. Coulter Counter and Nanoparticle Tracking Analysis (NTA) were used to measure the particle size distributions at the micro and nanoparticle size ranges, respectively. Microspheres were used to determine what camera settings yielded more accurate sizing and to reduce bias in the NTA analysis. Increasing milling cycles generally increased the number of smaller particles. The evolution of the measured size distributions indicated that small nanosized fragments broke off from larger MPs during cryomilling, steadily eroding larger MP fragments. The number of milling cycles was observed to more consistently impact the size distributions of fragments compared to the frequency of milling. This study offers both analysis of the cryomilling process and recommendations for generating more realistic PS MP/NPs for examining environmental fate and effects.

Published
2023
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48. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial

Author

Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmad, M, Ahmed, N, Ahmed, O, Ahmed, R, Ahmad, S, Ahmed, S H, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, A, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Alegria, A, Alexander, C, Alexander, J, Alexander, P, Al-Fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, F, Ali, J, Ali, M, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Aliyuda, F, Alizaedeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, 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Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A

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2024
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50. Use of an Artificial Intelligence-Generated Vascular Severity Score Improved Plus Disease Diagnosis in Retinopathy of Prematurity

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Coyner, Aaron S., Young, Benjamin K., Ostmo, Susan R., Grigorian, Florin, Ells, Anna, Hubbard, Baker, Rodriguez, Sarah H., Rishi, Pukhraj, Miller, Aaron M., Bhatt, Amit R., Agarwal-Sinha, Swati, Sears, Jonathan, Chan, R. V. Paul, Chiang, Michael F., Kalpathy-Cramer, Jayashree, Binenbaum, Gil, and Campbell, J. Peter

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2024
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