Search

BACKGROUND: Recent advances in resting-state fMRI allow us to study spatial dynamics, the phenomenon of brain networks spatially evolving over time. However, most dynamic studies still use subject-specific, spatially-static nodes. As recent studies have demonstrated, incorporating time-resolved spatial properties is crucial for precise functional connectivity estimation and gaining unique insights into brain function. Nevertheless, estimating time-resolved networks poses challenges due to the low signal-to-noise ratio, limited information in short time segments, and uncertain identification of corresponding networks within and between subjects. METHODS: We adapt a reference-informed network estimation technique to capture time-resolved spatial networks and their dynamic spatial integration and segregation. We focus on time-resolved spatial functional network connectivity (spFNC), an estimate of network spatial coupling, to study sex-specific alterations in schizophrenia and their links to multi-factorial genomic data. RESULTS: Our findings are consistent with the dysconnectivity and neurodevelopment hypotheses and align with the cerebello-thalamo-cortical, triple-network, and frontoparietal dysconnectivity models, helping to unify them. The potential unification offers a new understanding of the underlying mechanisms. Notably, the posterior default mode/salience spFNC exhibits sex-specific schizophrenia alteration during the state with the highest global network integration and correlates with genetic risk for schizophrenia. This dysfunction is also reflected in high-dimensional (voxel-level) space in regions with weak functional connectivity to corresponding networks. CONCLUSIONS: Our method can effectively capture spatially dynamic networks, detect nuanced SZ effects, and reveal the intricate relationship of dynamic information to genomic data. The results also underscore the potential of dynamic spatial dependence and weak connectivity in the clinical landscape.

The aim of this article is to solve the system XA=Y, where A=(ai,j)∈Mn×m(S), Y∈Sm and X is an unknown vector of a size n, with S being an additively idempotent semiring. If the system has solutions, then we completely characterize its maximal one, and in the particular case where S is a generalized tropical semiring, a complete characterization of its solutions is provided as well as an explicit bound of the computational cost associated with its computation. Finally, we show how to apply this method to cryptanalyze two different key exchange protocols defined for a finite case and the tropical semiring, respectively.

We present an active attack that targets Ateniese et al.’s authenticated group key agreement, which, as a particular case, includes the well-known multiparty key exchange protocol CLIQUES that allows a group of users to build a common secret using some private values in a collaborative and distributed way, naturally extending the foundational key exchange introduced by Diffie and Hellman between two communicating parties that motivated the birth of public key cryptography. Ateniese et al.’s protocol adds some authentication information, allowing the parties to trust the exchanged information, but we show that it is possible to surpass this as well. The attack allows a malicious party to agree on a secret with the rest of the legal members of the group without their knowledge, so all the distributed information can be accessed using this secret. In addition, this is shown under a well-known cryptographic model that, in principle, requires absolute control of group communications, but, in fact, it only requires malicious control of the communications of a single arbitrary user and only for the duration of the key exchange. This means that after the attack, the malicious party does not have to take any other actions that could reveal a clue that an attack occurred and that the distributed information is being illegally accessed, contrary to a typical man-in-the-middle attack where the attacker has to continue the activity, meaning this could be detected at some point.

Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature of schizophrenia and is frequently present in other major psychiatric illnesses. Studies in individuals with first-episode (FEP) and early psychosis (EP) have the potential to interpret aberrant connectivity associated with psychosis during a period with minimal influence from medication and other confounds. The current study uses a data-driven whole-brain approach to examine patterns of aberrant functional network connectivity (FNC) in a multi-site dataset comprising resting-state functional magnetic resonance images (rs-fMRI) from 117 individuals with FEP or EP and 130 individuals without a psychiatric disorder, as controls. Accounting for age, sex, race, head motion, and multiple imaging sites, differences in FNC were identified between psychosis and control participants in cortical (namely the inferior frontal gyrus, superior medial frontal gyrus, postcentral gyrus, supplementary motor area, posterior cingulate cortex, and superior and middle temporal gyri), subcortical (the caudate, thalamus, subthalamus, and hippocampus), and cerebellar regions. The prominent pattern of reduced cerebellar connectivity in psychosis is especially noteworthy, as most studies focus on cortical and subcortical regions, neglecting the cerebellum. The dysconnectivity reported here may indicate disruptions in cortical-subcortical-cerebellar circuitry involved in rudimentary cognitive functions which may serve as reliable correlates of psychosis.

The influenza virus has accompanied humans since time immemorial, in the form of annual epidemics and occasional pandemics. It is a respiratory infection with multiple repercussions on people’s lives at an individual and social level, as well as representing a significant burden on the health system. This Consensus Document arises from the collaboration of various Spanish scientific societies involved in influenza virus infection. The conclusions drawn are based on the highest quality evidence available in the scientific literature and, failing that, on the opinion of the experts convened. The Consensus Document addresses the clinical, microbiological, therapeutic, and preventive aspects (with respect to the prevention of transmission and in relation to vaccination) of influenza, for both adult and pediatric populations. This Consensus Document aims to help facilitate the clinical, microbiological, and preventive approach to influenza virus infection and, consequently, to reduce its important consequences on the morbidity and mortality of the population. Resumen: El virus de la gripe ha acompañado al ser humano desde tiempo inmemorial, en forma de epidemias anuales y pandemias ocasionales. Se trata de una infección respiratoria con múltiples repercusiones sobre la vida de las personas a nivel individual y social, así como una importante sobrecarga para el sistema sanitario. El presente documento de consenso surge de la colaboración de diversas sociedades científicas españolas implicadas en la atención de la infección por virus de la gripe. Las conclusiones extraídas se han fundamentado en las evidencias de mayor calidad disponibles en la literatura científica y, en su defecto, en la opinión de los expertos convocados. En el documento de consenso se abordan los aspectos clínicos, microbiológicos, terapéuticos y preventivos (respecto de la prevención de la transmisión y en relación con la vacunación) de la gripe, tanto para población pediátrica como para adultos. Este documento de consenso pretende ayudar a facilitar el abordaje clínico, microbiológico y preventivo de la infección por virus de la gripe y, consecuentemente, a disminuir sus importantes consecuencias sobre la morbimortalidad de la población.

The aim of this article is to give lower bounds on the parameters of algebraic geometric error-correcting codes constructed from projective bundles over Deligne–Lusztig surfaces. The methods based on an intensive use of the intersection theory allow us to extend the codes previously constructed from higher-dimensional varieties, as well as those coming from curves. General bounds are obtained for the case of projective bundles of rank 2 over standard Deligne–Lusztig surfaces, and some explicit examples coming from surfaces of type A2 and 2A4 are given.

The combined cycle plants in 2019 are upswing due to definitive closure of conventional coal-fired power plants. The price increase of a ton of CO2, will close to 25 euros in 2019, could allow to increase their capacity factor above 50%. It has been already achieved a high flexibility imposed by the regulator of the Spanish network and possible hybridizations, in both gas turbine and heat recovery steam generator. Therefore, one step ahead directed to the reduction and treatment of the flow of exhaust gases at the outlet of the boiler during the operation is necessary.An optimization study based on a parametric analysis of this possible reduction has been carried out, with recirculation of the exhaust gases and the treatment of them with amines in a CO2 capture plant, both at the exit of the boiler, using real data base, to study their possible integration within the existing combined cycle.The results obtained are very promising: firstly, with the use a 35% of exhaust gases recirculation + capture plant in existing combined cycle, the efficiency of the gas turbine improves 0.5%. Secondly, the total number of tons of CO2 avoid per year would be around 633 kilotons (based on a capacity factor in 2019 closed to 0.41). Therefore, the saved cost in ton of CO2 for one existing combined cycle could be around 21.4 million of euros/year. This configuration, therefore, decreases the number of trains from 2 (existing combined cycle + capture plant) to 1.36. This decreasing is traduced in costs reduction and due to it an effective technique for pollutant emissions reduction.On the other hand, the new combined cycle will have an efficiency penalty caused by chemical absorption in the capture plant. The crossover requires approximately 30% of the middle/low steam of the turbine to obtaining 90% capture of CO2 with the corresponding penalty of 4 points in the global cycle performance and a reduction of power close to 21% with respect to the existing cycle. All boil down to a conflict of interests between €/Mw lost vs €/ton CO2avoided. Clearly the rising in capacity factor and flexibility in current combined cycle plants will be decisive in future to elucidate this conflict. The results obtained are totally in contrast with other studies carried out being fully feasible for implementation in existing combined cycles.

Introduction Virtual Communities of Practice (VCoP) or knowledge-sharing virtual communities offer ubiquitous access to information and exchange possibilities for people in similar situations, which might be especially valuable for the self-management of patients with chronic diseases. In view of the scarce evidence on the clinical and economic impact of these interventions on chronic conditions, we aim to evaluate the effectiveness and cost-effectiveness of a VCoP in the improvement of the activation and other patient empowerment measures in patients with ischaemic heart disease (IHD).Methods and analysis A pragmatic randomised controlled trial will be performed in Catalonia, Madrid and Canary Islands, Spain. Two hundred and fifty patients with a recent diagnosis of IHD attending the participating centres will be selected and randomised to the intervention or control group. The intervention group will be offered participation for 12 months in a VCoP based on a gamified web 2.0 platform where there is interaction with other patients and a multidisciplinary professional team. Intervention and control groups will receive usual care. The primary outcome will be measured with the Patient Activation Measure questionnaire at baseline, 6, 12 and 18 months. Secondary outcomes will include: clinical variables; knowledge (Questionnaire of Cardiovascular Risk Factors), attitudes (Self-efficacy Managing Chronic Disease Scale), adherence to the Mediterranean diet (Mediterranean Diet Questionnaire), level of physical activity (International Physical Activity Questionnaire), depression (Patient Health Questionnaire), anxiety (Hospital Anxiety Scale-A), medication adherence (Adherence to Refill Medication Scale), quality of life (EQ-5D-5L) and health resources use. Data will be collected from self-reported questionnaires and electronic medical records.Ethics and dissemination The trial was approved by Clinical Research Ethics Committee of Gregorio Marañón University Hospital in Madrid, Nuestra Señora de Candelaria University Hospital in Santa Cruz de Tenerife and IDIAP Jordi Gol in Barcelona. The results will be disseminated through workshops, policy briefs, peer-reviewed publications, local/international conferences.Trial registration number ClinicalTrials.gov Registry (NCT03959631). Pre-results.

introduction. Exposure to airborne pollen from certain plants can cause allergic disease, but allergens can also be found in non-pollen-bearing fractions of ambient air. This may explain why the allergic response in susceptible patients does not always coincide with the presence and magnitude of airborne pollen counts. Plantago pollen is an important cause of pollinosis in northern Mediterranean countries, but it is difficult to determine its incidence in allergies because Plantago pollen appears in the atmosphere at the same time as grass pollen. objective. The study aimed to investigate the relationship between the atmospheric concentration of Pla l 1 aeroallergen and Plantago pollen, and its incidence in a population group. materials and method. Pollen was sampled using a Hirst-type volumetric trap (Burkard™) and Burkard Cyclone sampler (Burkard™) for Pla l 1 allergen. Allergen was determined with a Pla l 1-specific ELISA. Serum-specific IgE levels to several plant allergens were measured with the EAST system. results. The aerobiological dynamics of Plantago pollen grains and Pla l 1 did not follow the same trend, whereas the sum of Plantago with some other pollen types showed a more similar behaviour. Of the 118 subjects tested, sera from 52 contained IgE to Plantago pollen, but only 5 were monosensitized. conclusions. The presence of Pla l 1 in the atmosphere depends not only on Plantago pollen but also on the pollen of other species from the Oleaceae family. Knowledge of the behaviour of allergen Pla l 1 in the atmosphere can help understand better asthma exacerbations associated with aeroallergens.

¿Es Castilla la «madre» de España o una «víctima» de ella? Este artículo no pretende responder a semejante pregunta, sino analizar el discurso de un conjunto de canciones populares que han desarrollado esos y otros tópicos en torno a la relación de Castilla con España, vinculando ese discurso al contexto en el que tales canciones han sido producidas y reproducidas. Se sostiene que esas composiciones son deudoras de los debates que los eruditos han mantenido sobre la articulación de ambas patrias y que la difusión de dichas canciones ha contribuido a que agentes ajenos a la intelectualidad adopten como suyas las ideas provenientes de esos debates y las incluyan en sus prácticas de identificación y diferenciación.

José Ortega y Gasset es el filósofo español más importante del siglo XX. Su pensamiento internacional ha sido poco estudiado. Este trabajo lo aborda en la primera etapa de su vida, hasta 1907 en que concluye su formación. Las ideas del joven Ortega surgen en ambientes muy contradictorios: de un lado, entre liberales y jesuítas; de otro, entre la decadencia española y una Alemania in crescendo.José Ortega y Gasset is the most important spanish philosopher in the XX century. His International idea has been studied scarcely. This work treats it in the firstperiod of his Ufe, unta 1907 when he ended his formation. The young Ortega 's ideas spring in very contrary ambients: on the one hand, between liberáis and jesuits; on the other hand, between the spanish fall and a Germany in crescendo.

En este artículo, el autor analiza la crisis europea y la depresión económica en el periodo de entreguerras, prestando atención principalmente a las repercusiones de estos hechos en la obra de José Ortega y Gasset y en Revista de Occidente. La crisis de conciencia y la idea de Europa, el papel de las élites y el acceso de las masas al poder social son las cuestiones fundamentales tratadas por los escritores de Revista de Occidente. También explica las soluciones económicas que propuso la revista.In this article, the author analyses the European crisis and the economic Depression in the inter-war period, paying attention principalty to the repercussions of these events in the work of José Ortega y Gasset and in Revista de Occidente. The chsisconsciounsness and the idea of Europa, the role of the élites and the accession of the masses to the social power are the fundamental questions treated by the whters of Revista de Occidente. Also, he explains the economic solutlons that the review proposes.

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. Exposure to airborne pollen from certain plants can cause allergic disease, but allergens can also be found in non-pollen-bearing fractions of ambient air. This may explain why the allergic response in susceptible patients does not always coincide with the presence and magnitude of airborne pollen counts. Plantago pollen is an important cause of pollinosis in northern Mediterranean countries, but it is difficult to determine its incidence in allergies because Plantago pollen appears in the atmosphere at the same time as grass pollen. Objective. The study aimed to investigate the relationship between the atmospheric concentration of Pla I 1 aeroallergen and Plantago pollen, and its incidence in a population group. Materials and method. Pollen was sampled using a Hirst-type volumetric trap (Burkard™) and Burkard Cyclone sampler (Burkard™) for Pla I 1 allergen. Allergen was determined with a Pla I 1-specific ELISA. Serum-specific IgE levels to several plant allergens were measured with the EAST system. Results. The aerobiological dynamics of Plantago pollen grains and Pla I 1 did not follow the same trend, whereas the sum of Plantago with some other pollen types showed a more similar behaviour. Of the 118 subjects tested, sera from 52 contained IgE to Plantago pollen, but only 5 were monosensitized. Conclusions. The presence of Pla I 1 in the atmosphere depends not only on Plantago pollen but also on the pollen of other species from the Oleaceae family. Knowledge of the behaviour of allergen Pla I 1 in the atmosphere can help understand better asthma exacerbations associated with aeroallergens. [ABSTRACT FROM AUTHOR]

Copyright of DYNA - Ingeniería e Industria is the property of Publicaciones Dyna SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Schizophrenia research reveals sex differences in incidence, symptoms, genetic risk factors, and brain function. However, a knowledge gap remains regarding sex-specific schizophrenia alterations in brain function. Schizophrenia is considered a dysconnectivity syndrome, but the dynamic integration and segregation of brain networks are poorly understood. Recent advances in resting-state functional magnetic resonance imaging allow us to study spatial dynamics, the phenomenon of brain networks spatially evolving over time. Nevertheless, estimating time-resolved networks remains challenging due to low signal-to-noise ratio, limited short-time information, and uncertain network identification., Methods: We adapted a reference-informed network estimation technique to capture time-resolved networks and their dynamic spatial integration and segregation for 193 individuals with schizophrenia and 315 control participants. We focused on time-resolved spatial functional network connectivity, an estimate of network spatial coupling, to study sex-specific alterations in schizophrenia and their links to genomic data., Results: Our findings are consistent with the dysconnectivity and neurodevelopment hypotheses and with the cerebello-thalamo-cortical, triple-network, and frontoparietal dysconnectivity models, helping to unify them. The potential unification offers a new understanding of the underlying mechanisms. Notably, the posterior default mode/salience spatial functional network connectivity exhibits sex-specific schizophrenia alteration during the state with the highest global network integration and is correlated with genetic risk for schizophrenia. This dysfunction is reflected in regions with weak functional connectivity to corresponding networks., Conclusions: Our method can effectively capture spatially dynamic networks, detect nuanced schizophrenia effects including sex-specific ones, and reveal the intricate relationship of dynamic information to genomic data. The results also underscore the clinical potential of dynamic spatial dependence and weak connectivity., (Copyright © 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)

Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature of schizophrenia and is frequently present in other major psychiatric illnesses. Studies in individuals with first-episode (FEP) and early psychosis (EP) have the potential to interpret aberrant connectivity associated with psychosis during a period with minimal influence from medication and other confounds. The current study uses a data-driven whole-brain approach to examine patterns of aberrant functional network connectivity (FNC) in a multi-site dataset comprising resting-state functional magnetic resonance images (rs-fMRI) from 117 individuals with FEP or EP and 130 individuals without a psychiatric disorder, as controls. Accounting for age, sex, race, head motion, and multiple imaging sites, differences in FNC were identified between psychosis and control participants in cortical (namely the inferior frontal gyrus, superior medial frontal gyrus, postcentral gyrus, supplementary motor area, posterior cingulate cortex, and superior and middle temporal gyri), subcortical (the caudate, thalamus, subthalamus, and hippocampus), and cerebellar regions. The prominent pattern of reduced cerebellar connectivity in psychosis is especially noteworthy, as most studies focus on cortical and subcortical regions, neglecting the cerebellum. The dysconnectivity reported here may indicate disruptions in cortical-subcortical-cerebellar circuitry involved in rudimentary cognitive functions which may serve as reliable correlates of psychosis., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)