37 results on '"Camargo JJ"'
Search Results
2. Long-term survival following unilateral lung transplantation for end-stage silicosis relative to idiopathic pulmonary fibrosis.
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Perin FA, Altmayer S, Nascimento DZ, Moreira-Hetzel G, Camargo SM, Hochhegger B, Sidney Filho LA, Camargo JJ, and Watte G
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- Humans, Idiopathic Pulmonary Fibrosis surgery, Lung Transplantation, Silicosis surgery
- Published
- 2022
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3. Ultrasound-Assisted Extraction of Bioactive Compounds from Annatto Seeds, Evaluation of Their Antimicrobial and Antioxidant Activity, and Identification of Main Compounds by LC/ESI-MS Analysis.
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Quintero Quiroz J, Naranjo Duran AM, Silva Garcia M, Ciro Gomez GL, and Rojas Camargo JJ
- Abstract
This study evaluated the antimicrobial activity (i.e., against Bacillus cereus and Staphylococcus aureus ) and the antioxidant activity (i.e., ABTS, FRAP, and DPPH) of annatto seeds extract obtained by ultrasound-assisted extraction. A response surface design with three levels such as pH (2-11), solvent concentration (50-96 %), seed-to-solvent ratio (1:2-1:10), and treatment time (0-30 min) was employed to determine the optimal experimental conditions. Thus, a pH of 7.0, seed-to-solvent ratio of 1:7, and treatment time of 20 min were selected as optimal rendering an extract having a 0.62% of bixin, 3.81 mg gallic acid/mg equivalent of polyphenol compounds (ABTS 1035.7, FRAP 424.7, and DPPH 1161.5 μ M trolox/L), and a minimal inhibitory concentration against Bacillus cereus and Staphylococcus aureus of 32 and 16 mg/L, respectively. Further, the main bioactive compounds identified by LC/ESI-MS were bixin and catechin, chlorogenic acid, chrysin, butein, hypolaetin, licochalcone A, and xanthohumol., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper
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- 2019
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4. Pulmonary rehabilitation improves survival in patients with idiopathic pulmonary fibrosis undergoing lung transplantation.
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Florian J, Watte G, Teixeira PJZ, Altmayer S, Schio SM, Sanchez LB, Nascimento DZ, Camargo SM, Perin FA, Camargo JJ, Felicetti JC, and Moreira JDS
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- Adult, Aged, Female, Humans, Idiopathic Pulmonary Fibrosis mortality, Kaplan-Meier Estimate, Male, Middle Aged, Perioperative Care, Prognosis, Recovery of Function, Rehabilitation methods, Respiration, Artificial, Respiratory Function Tests, Retrospective Studies, Treatment Outcome, Idiopathic Pulmonary Fibrosis rehabilitation, Idiopathic Pulmonary Fibrosis surgery, Lung Transplantation methods
- Abstract
This study was conducted to evaluate whether a pulmonary rehabilitation program (PRP) is independently associated with survival in patients with idiopathic pulmonary fibrosis (IPF) undergoing lung transplant (LTx). This quasi-experimental study included 89 patients who underwent LTx due to IPF. Thirty-two completed all 36 sessions in a PRP while on the waiting list for LTx (PRP group), and 53 completed fewer than 36 sessions (controls). Survival after LTx was the main outcome; invasive mechanical ventilation (IMV), length of stay (LOS) in intensive care unit (ICU) and in hospital were secondary outcomes. Kaplan-Meier curves and Cox regression models were used in survival analyses. Cox regression models showed that the PRP group had a reduced 54.0% (hazard ratio = 0.464, 95% confidence interval 0.222-0.970, p = 0.041) risk of death. A lower number of patients in the PRP group required IMV for more than 24 hours after LTx (9.0% vs. 41.6% p = 0.001). This group also spent a mean of 5 days less in the ICU (p = 0.004) and 5 days less in hospital (p = 0.046). In conclusion, PRP PRP completion halved the risk of cumulative mortality in patients with IPF undergoing unilateral LTx.
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- 2019
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5. Reply to Letter to the Editor re: Magnetic resonance imaging of pulmonary nodules: accuracy in a granulomatous disease-endemic region.
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Concatto NH, Watte G, Marchiori E, Irion K, Felicetti JC, Camargo JJ, and Hochhegger B
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- Diffusion Magnetic Resonance Imaging, Humans, Magnetic Resonance Imaging, Reproducibility of Results, Sensitivity and Specificity, Multiple Pulmonary Nodules, Solitary Pulmonary Nodule
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- 2017
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6. Magnetic resonance imaging of pulmonary nodules: accuracy in a granulomatous disease-endemic region.
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Henz Concatto N, Watte G, Marchiori E, Irion K, Felicetti JC, Camargo JJ, and Hochhegger B
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- Aged, Diagnosis, Differential, Female, Humans, Lung Neoplasms pathology, Male, Middle Aged, Multiple Pulmonary Nodules pathology, Reproducibility of Results, Sensitivity and Specificity, Solitary Pulmonary Nodule pathology, Spinal Cord Diseases, Tomography, X-Ray Computed, Diffusion Magnetic Resonance Imaging methods, Endemic Diseases, Granuloma, Lung Neoplasms diagnostic imaging, Multiple Pulmonary Nodules diagnostic imaging, Solitary Pulmonary Nodule diagnostic imaging
- Abstract
Objective: To estimate the diagnostic accuracy of signal intensity of the lesion-to-spinal cord ratio (LSR) and apparent diffusion coefficient (ADC) in diffusion-weighted (DW) magnetic resonance imaging of pulmonary nodules suspicious for lung cancer in granulomatous lung disease-endemic regions., Methods: Forty-nine patients with indeterminate solitary pulmonary nodules detected by chest computed tomography and histopathologically confirmed diagnoses were included in the study. DW images were analysed semiquantitatively by focusing regions of interest on the lesion and spinal cord at the same level (for LSR calculation). ADCs were estimated from ratios of the two image signal intensities. Ratios of T1 and T2 signal intensity between nodules and muscle were calculated for comparison., Results: Mean ADCs ± standard deviations for lung cancer and benign lesions were 0.9 ± 0.2 and 1.3 ± 0.2 × 10(-3) mm(2)/s, respectively. Mean LSRs were 1.4 ± 0.3 for lung cancer and 1 ± 0.1 for benign lesions. ADCs and LSRs differed significantly between malignant and benign lesions (P < 0.001). Mean T2 signal intensity ratios also differed significantly between benign and malignant lesions (0.8 ± 0.2 vs. 1.6 ± 0.2; P < 0.05)., Conclusions: DWI can help to differentiate malignant from benign lesions according to ADC and the LSR with good accuracy., Key Points: • DW imaging can help differentiate malignant from benign pulmonary nodules. • ADC and LSR signal intensities had only small overlap between malignant and benign pulmonary nodules. • Mean T2 signal intensity ratios differed significantly between benign and malignant lesions.
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- 2016
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7. PTX3-Based Genetic Testing for Risk of Aspergillosis After Lung Transplant.
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Cunha C, Monteiro AA, Oliveira-Coelho A, Kühne J, Rodrigues F, Sasaki SD, Schio SM, Camargo JJ, Mantovani A, Carvalho A, and Pasqualotto AC
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- Female, Humans, Male, C-Reactive Protein genetics, Fungi isolation & purification, Immunocompromised Host, Mycoses genetics, Mycoses immunology, Organ Transplantation adverse effects, Polymorphism, Genetic, Serum Amyloid P-Component genetics
- Published
- 2015
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8. Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation.
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Rubin AS, Nascimento DZ, Sanchez L, Watte G, Holand AR, Fassbind DA, and Camargo JJ
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- Adult, Aged, Female, Forced Expiratory Volume physiology, Humans, Idiopathic Pulmonary Fibrosis mortality, Male, Middle Aged, Respiratory Function Tests, Retrospective Studies, Survival Rate, Time Factors, Treatment Outcome, Vital Capacity physiology, Idiopathic Pulmonary Fibrosis physiopathology, Idiopathic Pulmonary Fibrosis surgery, Lung Transplantation mortality
- Abstract
Objective: To evaluate the changes in lung function in the first year after single lung transplantation in patients with idiopathic pulmonary fibrosis (IPF)., Methods: We retrospectively evaluated patients with IPF who underwent single lung transplantation between January of 2006 and December of 2012, reviewing the changes in the lung function occurring during the first year after the procedure., Results: Of the 218 patients undergoing lung transplantation during the study period, 79 (36.2%) had IPF. Of those 79 patients, 24 (30%) died, and 11 (14%) did not undergo spirometry at the end of the first year. Of the 44 patients included in the study, 29 (66%) were men. The mean age of the patients was 57 years. Before transplantation, mean FVC, FEV1, and FEV1/FVC ratio were 1.78 L (50% of predicted), 1.48 L (52% of predicted), and 83%, respectively. In the first month after transplantation, there was a mean increase of 12% in FVC (400 mL) and FEV1 (350 mL). In the third month after transplantation, there were additional increases, of 5% (170 mL) in FVC and 1% (50 mL) in FEV1. At the end of the first year, the functional improvement persisted, with a mean gain of 19% (620 mL) in FVC and 16% (430 mL) in FEV1., Conclusions: Single lung transplantation in IPF patients who survive for at least one year provides significant and progressive benefits in lung function during the first year. This procedure is an important therapeutic alternative in the management of IPF.
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- 2015
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9. Pulmonary diseases with imaging findings mimicking aspergilloma.
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Gazzoni FF, Severo LC, Marchiori E, Guimarães MD, Garcia TS, Irion KL, Camargo JJ, Felicetti JC, de Mattos Oliveira F, and Hochhegger B
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- Biopsy, Diagnosis, Differential, Humans, Lung microbiology, Lung pathology, Lung Diseases etiology, Lung Diseases pathology, Predictive Value of Tests, Prognosis, Pulmonary Aspergillosis microbiology, Pulmonary Aspergillosis pathology, Risk Factors, Lung diagnostic imaging, Lung Diseases diagnostic imaging, Pulmonary Aspergillosis diagnostic imaging, Tomography, X-Ray Computed
- Abstract
Patients with preexisting lung cavities are at risk of developing intracavitary fungal colonization. Because Aspergillus spp. are the most commonly implicated fungi, these fungal masses are called aspergillomas. Their characteristic "ball-in-hole" appearance, however, may be found in a variety of other conditions that can produce radiologic findings mimicking aspergilloma. In this paper, we review the main diseases that may mimic the radiographic findings of aspergilloma, with brief descriptions of clinical, radiologic, and histopathologic findings.
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- 2014
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10. Aspergillus fumigatus fungus ball in the native lung after single lung transplantation.
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Gazzoni FF, Hochhegger B, Severo LC, and Camargo JJ
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- Female, Humans, Middle Aged, Radiography, Aspergillus fumigatus isolation & purification, Lung Transplantation, Pulmonary Aspergillosis diagnostic imaging
- Published
- 2013
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11. Twelve-year survival of the first living-donor pediatric lung transplantation in Brazil.
- Author
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Machuca TN, Sidney Filho LA, Schio SM, Camargo SM, Felicetti JC, and Camargo JJ
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- Brazil, Child, Humans, Male, Survivors, Treatment Outcome, Bronchiolitis Obliterans therapy, Living Donors, Lung Transplantation standards
- Abstract
Objective: To report the long-term follow-up of the first living-donor lobar lung transplantation performed in Latin America., Description: The patient was a 12-year-old boy with post-infectious obliterative bronchiolitis with end-stage pulmonary disease. He was on continuous oxygen support, presenting with dyspnea even during minimal activity. He underwent bilateral lobar lung transplantation with living donors. The procedure was performed with the left and right lower lobes of two different related donors. In the second side cardiopulmonary bypass was required. The transplant was uneventful, and the patient was extubated after 14 hours and discharged with 44 days, after resolution of infectious, immunological and drug-related complications. After 12 years of follow-up, he presents with adequate lung function and has resumed his habitual activities., Comments: Living-donor lobar lung transplantation is a complex procedure feasible for the treatment of selected pediatric end-stage pulmonary disease. This particular population might benefit from this approach since the availability of pediatric donors is very scarce and the clinical course of pediatric advanced pulmonary disease may be unpredictable.
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- 2012
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12. Aspergillus fumigatus fungus ball in the pleural cavity.
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Guazzelli LS, Severo CB, Hoff LS, Pinto GL, Camargo JJ, and Severo LC
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- Adult, Aged, Aspergillosis microbiology, Female, Humans, Lung Diseases, Fungal microbiology, Male, Middle Aged, Pleural Cavity diagnostic imaging, Radiography, Retrospective Studies, Risk Factors, Aspergillosis diagnostic imaging, Aspergillus fumigatus isolation & purification, Lung Diseases, Fungal diagnostic imaging, Pleural Cavity microbiology
- Abstract
Objective: To report the cases of 6 patients with fungus ball caused by Aspergillus fumigatus (aspergilloma) in the pleural cavity., Methods: Between 1980 and 2009, 391 patients were diagnosed with aspergilloma at the Santa Casa Hospital Complex in Porto Alegre, Brazil. The diagnosis of aspergilloma in the pleural cavity was made through imaging tests revealing effusion and pleural thickening with air-fluid level; direct mycological examination revealing septate hyphae, consistent with Aspergillus sp.; and positive culture for A. fumigatus in the surgical specimen from the pleural cavity., Results: Of the 391 patients studied, 6 (2%) met the established diagnostic criteria. The mean age of those 6 patients was 48 years (range, 29-66 years), and 5 (83%) were male. The most common complaints were cough, expectoration, and hemoptysis. Four patients (67%) had a history of tuberculosis that had been clinically cured. All of the patients were submitted to surgical removal of the aspergilloma, followed by intrapleural instillation of amphotericin B, in 4; and 2 received systemic antifungal treatment p.o. There was clinical improvement in 5 patients, and 1 died after the surgery., Conclusions: In adult patients with a history of cavitary lung disease or pleural fistula, a careful investigation should be carried out and fungal infection, especially aspergilloma, should be taken into consideration. In such cases, laboratory testing represents the most efficient use of the resources available to elucidate the diagnosis.
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- 2012
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13. Guidelines for potential multiple organ donors (adult). Part III: organ-specific recommendations.
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Westphal GA, Caldeira Filho M, Vieira KD, Zaclikevis VR, Bartz MC, Wanzuita R, Réa-Neto A, Teixeira C, Franke C, Machado FO, Andrade Jd, Matos JD, Gerent KB, Fiorelli A, Gonçalves AR, Ferraz Neto BH, Dias FS, Carvalho FB, Costa G, Camargo JJ, Teles JM, Maia M, Nogara M, Coelho ME, Mazzali M, Youssef NC, Duarte P, Souza RL, Fernandes R, Camargo S, and Garcia VD
- Abstract
Brain death (BD) alters the pathophysiology of patients and may damage the kidneys, the lungs, the heart and the liver. To obtain better quality transplant organs, intensive care physicians in charge of the maintenance of deceased donors should attentively monitor these organs. Careful hemodynamic, ventilatory and bronchial clearance management minimizes the loss of kidneys and lungs. The evaluation of cardiac function and morphology supports the transplant viability assessment of the heart. The monitoring of liver function, the management of the patient's metabolic status and the evaluation of viral serology are fundamental for organ selection by the transplant teams and for the care of the transplant recipient.
- Published
- 2011
14. Prognostic factors in lung transplantation: the Santa Casa de Porto Alegre experience.
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Machuca TN, Schio SM, Camargo SM, Lobato V, Costa CD, Felicetti JC, Moreira JS, and Camargo JJ
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- Adult, Aged, Brazil, Cardiopulmonary Bypass, Central Venous Pressure, Female, Humans, Lung Transplantation adverse effects, Male, Middle Aged, Multivariate Analysis, Postoperative Complications etiology, Prognosis, Pulmonary Disease, Chronic Obstructive complications, Tissue Donors, Lung Transplantation mortality
- Abstract
Background: Lung transplantation (LT) has been established as a current therapy for selected patients with end-stage lung disease. Different prognostic factors have been reported by transplant centers. The objective of this study is to report our recent results with LT and to search for prognostic factors., Methods: We performed a retrospective analysis of 130 patients who underwent LT at our institution from January 2004 to July 2009. Donor, recipient, intraoperative, and postoperative variables were collected., Results: The mean age was 53.14 years (ranging from 8 to 72 years) and 80 (61.5%) were male. The main causes of end-stage respiratory disease were pulmonary fibrosis 53 (40.7%) and chronic obstructive pulmonary disease 52 (40%). The actuarial 1-year survival was 67.7%. Variables correlated with survival were age (P=0.004), distance in the 6-min walk test (P=0.007), coronary heart disease (P=0.001), cardiopulmonary bypass (P=0.02), intraoperative transfusion of red blood cells (P=0.016), increasing central venous pressure at 24th postoperative hour (P=0.001), increasing pulmonary capillary wedge pressure at 24th postoperative hour (P=0.01); length of intubation (P<0.01), reintubation (P=0.001), length of intensive care unit stay (P<0.001), abdominal complication (P=0.003), acute renal failure requiring dialysis (P<0.001), native lung hyperinflation (P=0.02), and acute rejection in the first month (P=0.03). In multivariate analysis, only dialysis (P=0.004, hazards ratio [HR] 2.68), length of intubation (P=0.004, HR 1.002 for each hour), and reintubation (P=0.003, HR 2.88) proved to be independent predictors., Conclusion: Analysis of variables in our cohort highlighted dialysis, longer mechanical ventilation requirement, and reintubation as independent prognostic factors in LT.
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- 2011
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15. Lung transplantation for lymphangioleiomyomatosis: single-center Brazilian experience with no chylothorax.
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Machuca TN, Losso MJ, Camargo SM, Schio SM, Melo IA, Hochhegger B, Felicetti JC, and Camargo JJ
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- Adult, Brazil, Female, Humans, Male, Middle Aged, Retrospective Studies, Lung Transplantation, Lymphangioleiomyomatosis surgery
- Abstract
Background: Lymphangioleiomyomatosis (LAM), a rare cystic disease characterized by proliferation of smooth muscle cells in the lung interstitium, almost exclusively affects females in their reproductive years. Lung transplantation has been established as effective therapy for end-stage pulmonary LAM., Methods: This retrospective study includes lung transplantation patients with LAM at a single institution between 1989 and 2009., Results: During the study period we performed 300 lung transplantations, and in 10 cases the recipients had LAM. All patients were females with a mean age of 43.8 years. The mean time from the diagnosis to lung transplantation was 5 years. Seven patients had experienced previous pneumothoraces, five of whom were treated with pleurodesis. In all patients we performed a single-lung transplantation (left-sided = 9 and right-sided = 1). In three cases, the pleurodesis was on the same side as the transplantation, with great intraoperative bleeding in one subject (left pleurectomy). There was one early death due to infective endocarditis at posttransplant day 19. The median length of mechanical ventilation was 13 hours, while the mean hospital stay was 16.75 days. There was no case of chylothorax. Late complications included one case of native lung pneumothorax, one diaphragmatic hernia, one posttransplant lymphoproliferative disease, one respiratory sepsis, and one mycobacterial infection. The 1- and 3-year survival rates were 90% and 80%, respectively., Conclusion: Lung transplantation is a feasible therapeutic option for patients with LAM, despite previous ipsilateral pleurodesis. The left-sided predilection for our procedures may have been responsible for the absence of chylothorax in this series., (Copyright © 2011. Published by Elsevier Inc.)
- Published
- 2011
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16. Lung transplantation for patients older than 65 years: is it a feasible option?
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Machuca TN, Camargo SM, Schio SM, Lobato V, Sanchez LB, Perin F, Felicetti JC, and Camargo JJ
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- Aged, Feasibility Studies, Female, Humans, Male, Retrospective Studies, Lung Transplantation
- Abstract
Background: Advanced age has been a relative contraindication to lung transplantation. However, the exact age limit for this procedure has not yet been established. The aim of this work is to present our experience with this particular group., Methods: This retrospective review included medical charts of patients who underwent lung transplantation at our institution from January 2004 to February 2009: namely, 112 cadaveric lung transplants with 12 patients (10.7%) >65 years old., Results: There were 9 male patients and the overall mean age was 68 years (range 66-72). The indications were pulmonary fibrosis in 8 and emphysema in 4 cases. Four patients had mild coronary artery disease and 4 systemic hypertension. All of the procedures were unilateral and only 2 required extracorporeal circulation. Only 5 patients received blood product transfusions intraoperatively; the mean ischemic time was 222 minutes. Four patients developed primary graft dysfunction, the mean requirement for mechanical ventilation was 30 hours, and the mean intensive care unit stay, 11 days. Postoperative complications were respiratory infections (n = 8), catheter-related infection (n = 1), atrial fibrillation (n = 2). The mean hospital stay was 28 days and the 1-year survival was 75%., Conclusion: Lung transplantation is a feasible option for well-selected patients with end-stage pulmonary disease who are >65 years old. Our study reinforces the modern trend for unilateral procedures in this situation., (Copyright © 2011 Elsevier Inc. All rights reserved.)
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- 2011
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17. Surgical treatment of bronchial carcinoid tumors: a single-center experience.
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Machuca TN, Cardoso PF, Camargo SM, Signori L, Andrade CF, Moreira AL, Moreira Jda S, Felicetti JC, and Camargo JJ
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- Adolescent, Adult, Aged, Aged, 80 and over, Bronchial Neoplasms pathology, Bronchial Neoplasms physiopathology, Carcinoid Tumor pathology, Carcinoid Tumor physiopathology, Female, Fiber Optic Technology trends, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Prognosis, Risk Factors, Survival Analysis, Treatment Outcome, Bronchial Neoplasms diagnosis, Bronchial Neoplasms surgery, Bronchoscopy methods, Bronchoscopy mortality, Carcinoid Tumor diagnosis, Carcinoid Tumor surgery
- Abstract
Background: Bronchial carcinoid is an infrequent neoplasm with a neuroendocrine differentiation. Surgical treatment is the gold standard therapy, with procedures varying from sublobar resections to complex lung sparing broncoplastic procedures. This study evaluates the results of surgical treatment of bronchial carcinoids and its prognostic factors., Patients and Methods: Retrospective review of 126 consecutive patients who underwent surgical treatment for bronchial carcinoid tumors between December 1974 and July 2007., Results: There were 70 females (55%) and the mean age was 46 years, ranging from 17 to 81 years. Upon clinical presentation, 38 patients (30%) have had recurrent respiratory tract infection, 31 (24%) cough, 16 (12%) chest pain and 25 (20%) were asymptomatic. Preoperative bronchoscopic diagnosis was obtained in 74 cases (58.7%). The procedures performed were: 19 sublobar resections (14,9%), 58 lobectomies (46%), 8 bilobectomies (6.3%), 6 pneumonectomies (4.7%), 2 sleeve segmentectomies (1.5%), 26 sleeve lobectomies (20.6%) and 9 bronchoplastic procedures without lung resection (7.1%). Operative mortality was 1.5% (n = 2) and morbidity was 25.8% (n=32), including 12 respiratory tract infections and 4 reinterventions due to bleeding (3) and pleural empyema (1). Among the 112 patients available for follow-up, the overall survival at 3, 5 and 10 years was 89.2%, 85.5% and 79.8%, respectively. Five and 10-year survival for typical and atypical carcinoids were 91, 89% and 56, 47%, respectively. Overall disease-free survival at 5 years was 91.9% Statistical analysis showed that overall disease-free survival correlated with histology--typical vs. atypical--(p = 0.04) and stage (p = 0.02)., Conclusion: Surgery provides safe and adequate treatment to bronchial carcinoid tumors. Histology and stage were the main prognostic factors., (Copyright © 2010. Published by Elsevier Ireland Ltd.)
- Published
- 2010
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18. Diagnosis of invasive aspergillosis in lung transplant recipients by detection of galactomannan in the bronchoalveolar lavage fluid.
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Pasqualotto AC, Xavier MO, Sánchez LB, de Oliveira Costa CD, Schio SM, Camargo SM, Camargo JJ, Sukiennik TC, and Severo LC
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- Adolescent, Adult, Aged, Antifungal Agents administration & dosage, Biomarkers analysis, Bronchoscopy, Chi-Square Distribution, Child, False Positive Reactions, Female, Galactose analogs & derivatives, Humans, Immunosuppressive Agents adverse effects, Invasive Pulmonary Aspergillosis etiology, Invasive Pulmonary Aspergillosis metabolism, Invasive Pulmonary Aspergillosis mortality, Lung Transplantation mortality, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, ROC Curve, Reagent Kits, Diagnostic, Sensitivity and Specificity, Treatment Outcome, Young Adult, Bronchoalveolar Lavage Fluid chemistry, Invasive Pulmonary Aspergillosis diagnosis, Lung Transplantation adverse effects, Mannans analysis
- Abstract
Background: Galactomannan (GM) detection in serum samples has been used to diagnose invasive aspergillosis (IA). Limited sensitivity has been observed in lung transplant recipients, for whom bronchoalveolar lavage (BAL) testing has been advocated. Because airway colonization with Aspergillus species occurs frequently in these patients, false-positive GM results have been reported if the cutoff validated for sera is used (i.e., 0.5)., Methods: Herein, we prospectively studied BAL fluid samples from 60 lung transplant patients to determine the optimal cutoff for BAL GM testing. Only one sample per patient was studied. BAL samples were vortexed and processed according to the manufacturer's instructions for serum samples. Sensitivity, specificity, and likelihood ratios were calculated in reference to proven or probable IA cases using receiver operating characteristic analysis., Results: Eight patients had IA during the study (incidence 13.3%), including four patients with proven IA. Aspergillosis increased 5-fold the risk of death in lung transplant recipients. The positive predictive value of a positive BAL GM test at the 0.5 cutoff was low (24.2%). Raising the cutoff improved test specificity without compromising sensitivity. The best cutoff was defined at 1.5 (sensitivity 100% and specificity 90.4%)., Conclusions: This study reinforces the importance of BAL GM testing in lung transplant recipients, particularly to exclude the diagnosis of IA. To minimize the frequency of false-positive results, a higher test cutoff should be applied to BAL samples, in comparison with serum samples.
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- 2010
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19. Surgical treatment of benign tracheo-oesophageal fistulas with tracheal resection and oesophageal primary closure: is the muscle flap really necessary?
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Camargo JJ, Machuca TN, Camargo SM, Lobato VF, and Medina CR
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- Adolescent, Adult, Aged, Anastomosis, Surgical methods, Esophagus surgery, Female, Follow-Up Studies, Humans, Intubation, Intratracheal, Male, Middle Aged, Muscle, Skeletal transplantation, Reoperation methods, Tracheal Stenosis complications, Tracheal Stenosis surgery, Tracheoesophageal Fistula etiology, Tracheoesophageal Fistula prevention & control, Treatment Outcome, Unnecessary Procedures, Young Adult, Surgical Flaps, Tracheoesophageal Fistula surgery
- Abstract
Objectives: Nowadays, despite the advances of the low-pressure high-volume cuffs, post-intubation tracheo-oesophageal fistula (TEF) still poses a major challenge to thoracic surgeons. The original technique includes interposition of muscle flaps between suture lines to avoid recurrence. It is not clear if this manoeuvre is indispensable and, in fact, we and others have faced problems with it. Our aim is to present our experience with TEF management in a consecutive group with no muscle interposition., Methods: From June 1992 to November 2007, we evaluated 14 patients presenting with TEF, with a mean age of 44 years (from 18 to 79 years). Thirteen patients had a prolonged intubation history. The remaining case was a 40-year-old male with congenital TEF. Three patients had been previously submitted to failed repairs in other institutions. Ten patients had associated tracheal stenosis, which was subglottic in three of them. Regarding surgical technique, in all cases, we performed a single-staged procedure, which consisted of tracheal resection and anastomosis with double-layer oesophageal closure. In none of our cases was a muscle flap interposed between suture lines., Results: All operations were performed through a cervical incision; however, in one case, an extension with partial sternotomy was required. There was no operative mortality. Thirteen patients were extubated in the first 24h after the procedure, while one patient required 48 h of mechanical ventilation. Four complications were recorded: one each of pneumonia and left vocal cord paralysis and two small tracheal dehiscences managed with a T-tube and a tracheostomy tube. After discharge, three patients returned to their native cities and were lost to follow-up. The remaining 11 patients have been followed up by a mean of 32 months (from three to 108 months), with 10 presenting excellent and one good anatomic and functional results., Conclusions: The single-staged repair with tracheal resection and anastomosis with oesophageal closure provides good short- and mid-term results for TEF management. The interposition of a muscle flap between suture lines may not be crucial to prevent recurrence., (Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.)
- Published
- 2010
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20. Computed tomography measurement of lung volume in preoperative assessment for living donor lung transplantation: volume calculation using 3D surface rendering in the determination of size compatibility.
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Camargo JJ, Irion KL, Marchiori E, Hochhegger B, Porto NS, Moraes BG, Meyer G, Caramori M, and Holemans JA
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- Adolescent, Child, Chronic Disease, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Lung anatomy & histology, Organ Size, Preoperative Care, Living Donors, Lung diagnostic imaging, Lung Diseases surgery, Lung Transplantation, Tomography, Spiral Computed
- Abstract
The objective of this study was to describe the use of CT volume quantification assessment of candidates for LLDLT. Six pediatric candidates for LDLLT and their donors were investigated with helical chest CT, as part of the preoperative assessment. The CT images were analyzed as per routine and additional post-processing with CT volume quantification (CT densitovolumetry) was performed to assess volume matching between the lower lobes of the donors and respective lungs of the receptors. CT images were segmented by density and region of interest, using post-processing software. Size matching was also assessed using the FVC formula. Compatible volumes were found in three cases. The other three cases were considered incompatible. All three recipients with compatible sizes survived the procedure and are alive and well. One patient with incompatible size was submitted to the procedure and died because of complications attributed to the incompatible volumes. One patient with incompatible size has subsequently grown and new measurements are to be taken to check the current volumes. Different donors are being sought for the remaining patient whose lung volumes were considered too big for the prospective transplant donor lobes. Under FVC formula criteria, all cases were considered compatible. CT volume quantification is an easy to perform, non-invasive technique that uses CT images for the preassessment of candidates for LDLLT, to compare the volume of the lower lobes from the donors with volume of each lung in the prospective recipients. Size matching based on CT densitovolumetry and FVC may differ.
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- 2009
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21. Computed tomography findings of postoperative complications in lung transplantation.
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Hochhegger B, Irion KL, Marchiori E, Bello R, Moreira J, and Camargo JJ
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- Brazil epidemiology, Graft Rejection diagnostic imaging, Humans, Lung Transplantation adverse effects, Lymphoproliferative Disorders diagnostic imaging, Pleural Effusion diagnostic imaging, Pneumonia diagnostic imaging, Postoperative Complications epidemiology, Prevalence, Retrospective Studies, Tomography, X-Ray Computed, Lung Transplantation diagnostic imaging, Postoperative Complications diagnostic imaging
- Abstract
Due to the increasing number and improved survival of lung transplant recipients, radiologists should be aware of the imaging features of the postoperative complications that can occur in such patients. The early treatment of complications is important for the long-term survival of lung transplant recipients. Frequently, HRCT plays a central role in the investigation of such complications. Early recognition of the signs of complications allows treatment to be initiated earlier, which improves survival. The aim of this pictorial review was to demonstrate the CT scan appearance of pulmonary complications such as reperfusion edema, acute rejection, infection, pulmonary thromboembolism, chronic rejection, bronchiolitis obliterans syndrome, cryptogenic organizing pneumonia, post-transplant lymphoproliferative disorder, bronchial dehiscence and bronchial stenosis.
- Published
- 2009
- Full Text
- View/download PDF
22. Multiple synchronous bronchial carcinoid tumors: report of a case.
- Author
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Camargo SM, Machuca TN, Moreira AL, Schio SM, Moreira JS, and Camargo JJ
- Subjects
- Bronchial Neoplasms diagnostic imaging, Bronchial Neoplasms surgery, Carcinoid Tumor diagnostic imaging, Carcinoid Tumor surgery, Female, Humans, Lymph Node Excision, Middle Aged, Thoracotomy, Tomography, X-Ray Computed, Treatment Outcome, Bronchial Neoplasms pathology, Carcinoid Tumor pathology, Neoplasms, Multiple Primary
- Abstract
Peripheral bronchial carcinoids are uncommon. Their presentation as synchronous tumors is rare and limited to anecdotal cases.We report the case of a 62-year-old female with the radiological finding of multiple bilateral nodular lesions. Bilateral sequential thoracotomies were performed and all three nodules were treated by sublobar resections. Pathological examination revealed all specimens to be carcinoid tumors and subsequent investigation confirmed the lung as the primary site. A review of previous cases of multiple carcinoids is presented and the particularities of their management are discussed.
- Published
- 2009
- Full Text
- View/download PDF
23. Invasive pulmonary aspergillosis due to a mixed infection caused by Aspergillus flavus and Aspergillus fumigatus.
- Author
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Orzechowski Xavier M, Pasqualotto AC, Uchoa Sales Mda P, Bittencourt Severo C, Peixoto Camargo JJ, and Severo LC
- Subjects
- Adult, Fatal Outcome, Humans, Male, Aspergillus flavus, Aspergillus fumigatus, Invasive Pulmonary Aspergillosis microbiology
- Abstract
Invasive pulmonary aspergillosis is typically caused by a single Aspergillus species, most frequently Aspergillus fumigatus. Here we report that a lung transplant recipient developed invasive aspergillosis due to a mixed infection caused by Aspergillus flavus and A. fumigatus. The implications for this unusual finding are discussed.
- Published
- 2008
- Full Text
- View/download PDF
24. Round pneumonia: a rare condition mimicking bronchogenic carcinoma. Case report and review of the literature.
- Author
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Camargo JJ, Camargo SM, Machuca TN, and Perin FA
- Subjects
- Diagnosis, Differential, Female, Humans, Middle Aged, Radiography, Carcinoma, Bronchogenic diagnostic imaging, Lung Neoplasms diagnostic imaging, Pneumonia diagnostic imaging
- Abstract
Context: Round pneumonia is a condition usually described in children, with few reports addressing adult patients. It is an oval-shaped consolidation that, due to its radiological appearance, simulates bronchogenic carcinoma. Its evolution tends to be benign, although diagnostic dilemmas have sometimes required exploratory thoracotomy. Deaths caused by this condition have even been reported. To the best of our knowledge, there have been 31 previous cases of round pneumonia in adults reported in the English and Portuguese-language literature, of which only one was completely asymptomatic., Case Report: The case of a 54-year-old female patient presenting a lung mass found on routine imaging evaluation is reported. Respiratory symptoms and signs were absent, but the patient had a significant history of smoking. Her physical examination gave normal results. On chest radiographs, a mass located in the middle third of the right lung was observed. Three weeks after the initial evaluation, the patient was admitted for a complete evaluation and for staging of a pulmonary malignancy, but repeated chest radiographs showed complete resolution.
- Published
- 2008
- Full Text
- View/download PDF
25. Intraoperative detection of sentinel lymph nodes using Patent Blue V in non-small cell lung cancer.
- Author
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Bustos ME, Camargo JJ, Resin Geyer G, and Feijó Andrade C
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung secondary, Feasibility Studies, Female, Humans, Lung pathology, Lung Neoplasms pathology, Lung Neoplasms secondary, Male, Mediastinum, Middle Aged, Neoplasm Staging, Patient Selection, Prospective Studies, Sensitivity and Specificity, Carcinoma, Non-Small-Cell Lung surgery, Coloring Agents, Intraoperative Care, Lung Neoplasms surgery, Lymphatic Metastasis diagnosis, Sentinel Lymph Node Biopsy
- Abstract
Aim: The aim of this article was to determine sentinel lymph node (SLN) identification rate (IR) using Patent Blue V in patients with non-small cell lung cancer (NSCLC) and to evaluate the accuracy of SLN for the presence of mediastinal metastasis., Methods: Between 2004 and 2006 the data from 32 patients with clinical stage IA to IIB, who underwent lung resection for NSCLC, were prospectively analyzed. Patent blue V dye was injected in the peritumoral tissue, and the first lymph node to stain was identified as a sentinel node., Results: SLN was identified in fifteen patients (IR=46.9%). SLN with metastatic involvement was observed in four patients. Accuracy, sensitivity and specificity of the sentinel lymph node in predicting the status of other mediastinal lymph node stations were respectively 86.7%, 100%, and 84.6%. In 63.1% patients, the SLNs corresponded to the lymph node stations 10 and 11. In seven patients (36.9%), the SLNs were located in the N2 stations., Conclusion: Although the use of Patent Blue V for SLN identification is feasible, this technique presents relatively low identification rate. The major difficulty on the detection of SLNs was the black coloration of the lymph node, which interfered with the visualization of the dye.
- Published
- 2008
26. The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir.
- Author
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Schröeder R, Michelon T, Wurdig J, Fagundes I, Schio S, Sanchez L, Camargo JJ, Sukkienik TC, Pasqualotto AC, and Neumann J
- Subjects
- Adolescent, Adult, Aged, Child, Cohort Studies, Cytomegalovirus Infections epidemiology, Cytomegalovirus Infections immunology, Female, Humans, Immunocompromised Host, Incidence, Infusions, Intravenous, Male, Middle Aged, Postoperative Complications prevention & control, Retrospective Studies, Antiviral Agents administration & dosage, Cytomegalovirus Infections prevention & control, Ganciclovir administration & dosage, Lung Transplantation
- Abstract
The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis.
- Published
- 2007
- Full Text
- View/download PDF
27. [Guideline for diagnosis, evaluation and therapeutic of pulmonary hypertension].
- Author
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Guimarães JI, Lopes AA, Martins RF, Aiello VD, Carvalho AC, Almeida DR, Martinez Filho EE, Kajita LJ, Cadê JR, Barreto AC, Afiune JY, Jatene FB, Bernardo WM, Monteiro R, Terra Filho M, Martins RF, Camargo JJ, and Meyer GM
- Subjects
- Humans, Hypertension, Pulmonary diagnosis, Hypertension, Pulmonary etiology, Hypertension, Pulmonary therapy
- Published
- 2003
28. [Lung transplant in children].
- Author
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Camargo JJ
- Abstract
Objective: This article presents a review of the main aspects related to lung transplant in children and shows the experience of the first medical team to perform this procedure in Latin America., Sources: Literature review of scientific articles, using the MEDLINE and Lilacs databases., Summary of the Findings: The article was organized into topics. Similarities and differences regarding lung transplant in adults were identified. Specific problems presented by children subjected to transplant are discussed, and special emphasis is given to a specific situation: lung transplant with living related donors., Conclusions: Advances in adult lung transplant for the treatment of parenchymatous or vascular lung diseases have been successfully employed in the pediatric population during the last few years.
- Published
- 2002
29. [Organ transplantation in childhood: a chimera?]
- Author
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Camargo JJ
- Published
- 2000
- Full Text
- View/download PDF
30. Clinical course of postinfectious bronchiolitis obliterans.
- Author
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Zhang L, Irion K, Kozakewich H, Reid L, Camargo JJ, da Silva Porto N, and Abreu e Silva FA
- Subjects
- Acute Disease, Age of Onset, Atrophy, Female, Follow-Up Studies, Humans, Immunoglobulin E analysis, Infant, Male, Prognosis, Prospective Studies, Bronchiolitis Obliterans pathology, Bronchiolitis, Viral complications
- Abstract
We performed a prospective observational study to define the clinical course and the prognostic factors of 31 patients with postinfectious bronchiolitis obliterans. All patients presented with an episode of acute bronchiolitis in the first 2 years of life, and respiratory symptoms and signs persisted since then. Other diseases which may cause chronic airflow obstruction were excluded. The patients were followed after their inclusion in the study and the clinical findings were recorded in a standardized questionnaire and form. Repeated chest radiographs and lung perfusion scans were obtained in all 31 patients and semiannual spirometry was performed in 8 older patients. Eight patients had lung biopsies. The clinical course varied in the 31 patients during a mean of 3.5 years of follow-up. The outcome of the patients included clinical remission (22.6%), persistence of respiratory symptoms and signs (67.7%), and death (9.7%). An older age at onset of illness and presence of atopy as suggested by an elevated serum IgE appeared to predispose to a poor prognosis., (Copyright 2000 Wiley-Liss, Inc.)
- Published
- 2000
- Full Text
- View/download PDF
31. Bronchopulmonary lavage in alveolar microlithiasis.
- Author
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Palombini BC, Porto NS, Wallau CV, and Camargo JJ
- Subjects
- Adolescent, Female, Humans, Lung Diseases therapy, Calculi therapy, Pulmonary Alveoli, Therapeutic Irrigation
- Published
- 1978
32. Adiaspiromycosis treated successfully with ketoconazole.
- Author
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Severo LC, Geyer GR, Camargo JJ, and Porto NS
- Subjects
- Adult, Chrysosporium drug effects, Humans, Ketoconazole pharmacology, Lung Diseases, Fungal pathology, Male, Ketoconazole therapeutic use, Lung Diseases, Fungal drug therapy
- Abstract
We describe a case of adiaspiromycosis in a 37-year-old male Caucasian. This is the first reported case with diffuse involvement of both lungs in a severely ill patient treated successfully with antifungal chemotherapy.
- Published
- 1989
- Full Text
- View/download PDF
33. Multiple paracoccidioidomas simulating Wegener's granulomatosis.
- Author
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Severo LC, Porto NS, Camargo JJ, and Geyer GR
- Subjects
- Adult, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Paracoccidioidomycosis diagnostic imaging, Paracoccidioidomycosis pathology, Radiography, Granulomatosis with Polyangiitis etiology, Paracoccidioidomycosis diagnosis
- Abstract
Five cases of paracoccidioidomas are reviewed. One case with multiple coin-lesions simulating Wegener's granulomatosis is described.
- Published
- 1985
- Full Text
- View/download PDF
34. Actinomycotic intracavitary lung colonization.
- Author
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Severo LC, Kaemmerer A, Camargo JJ, and Porto NS
- Subjects
- Actinomycosis complications, Adult, Aged, Female, Humans, Lung Diseases complications, Lung Diseases, Fungal pathology, Male, Middle Aged, Actinomycosis pathology, Diabetes Complications, Lung Diseases pathology
- Abstract
We describe four cases of actinomycotic intracavitary lung colonization and review the literature on the subject. Aspergillus fumigatus, A. niger, A. flavus, Pseudallescheria boydii are responsible for the majority of fungi intracavitary lung colonization (fungus ball). The similarities in clinical symptom (haemoptysis) and radiologic feature (pulmonary air meniscus) of fungus ball and actinomycotic intracavitary colonization prompted the investigation into a range of microorganisms, including Nocardia spp. and Actinomyces spp. We report four cases of such actinomycotic syndrome, three of them in diabetic patients, and review briefly the literature.
- Published
- 1989
- Full Text
- View/download PDF
35. Syngamosis: two new Brazilian cases and evidence of a possible pulmonary cycle.
- Author
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Severo LC, Conci LM, Camargo JJ, Andre-Alves MR, and Palombini BC
- Subjects
- Adult, Animals, Brazil, Female, Helminths physiology, Host-Parasite Interactions, Humans, Lung parasitology, Lung Diseases, Parasitic parasitology, Middle Aged, Radiography, Lung diagnostic imaging, Lung Diseases, Parasitic diagnostic imaging, Strongylida Infections diagnostic imaging
- Abstract
Cases of syngamosis due to Mammomanogamus laryngeus are reported, with a discussion of diagnostic aspects. A pulmonary cycle for M. laryngeus is proposed, suggested by the appearance of a transient area of homogeneous consolidation of the lung, detected by X-ray.
- Published
- 1988
- Full Text
- View/download PDF
36. Bronchopulmonary lavage in alveolar microlithiasis.
- Author
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Palombini BC, da Silva Porto N, Wallau CU, and Camargo JJ
- Subjects
- Adolescent, Bronchography, Calculi diagnostic imaging, Calculi therapy, Female, Humans, Lung diagnostic imaging, Lung Diseases diagnostic imaging, Lung Diseases therapy, Pulmonary Alveoli diagnostic imaging, Bronchi physiopathology, Calculi physiopathology, Lung Diseases physiopathology, Pulmonary Alveoli physiopathology, Therapeutic Irrigation methods
- Abstract
We describe the first known use of volume-controlled bronchopulmonary lavage in a case of alveolar microlithiasis. Although the procedure has often been discussed in the literature as theoretically useful in the therapy for this disease, in our case it showed no efficacy in clearing the alveolar spherules.
- Published
- 1981
- Full Text
- View/download PDF
37. Acute pulmonary histoplasmosis and first isolation of Histoplasma capsulatum from soil of Rio Grande do Sul, Brazil.
- Author
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Severo LC, Petrillo VF, Camargo JJ, Geyer GR, and Porto NS
- Subjects
- Adult, Brazil, Follow-Up Studies, Histoplasmosis diagnosis, Humans, Lung Diseases, Fungal diagnosis, Male, Histoplasma isolation & purification, Histoplasmosis epidemiology, Lung Diseases, Fungal epidemiology, Soil Microbiology
- Published
- 1986
- Full Text
- View/download PDF
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