77 results on '"Camara, P. G."'
Search Results
2. Finite size effects in the phase transition patterns of coupled scalar field systems
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Câmara, Lucas G. and Ramos, Rudnei O.
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High Energy Physics - Phenomenology ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory - Abstract
It is considered in this work the phase transition patterns for a coupled two-scalar field system model under the combined effects of finite sizes and temperature. The scalar fields are taken as propagating in a D=4 Euclidean space with the usual periodic compactification in the Euclidean time direction (with dimension given by the inverse of the temperature) and also under a compact dimension in the space direction, which is restricted to size L. In the latter case, a Dirichlet boundary condition is considered. Finite-size variation of the critical temperature for the cases of symmetry restoration and inverse symmetry breaking are studied. At fixed finite-temperature values, the variation of the inverse correlation lengths with the size L might display a behavior analogous to reentrant phase transitions. Possible applications of our results to physical systems of interest are also discussed., Comment: 19 pages, 8 figures. Many clarifications added. Version matching the published one in the Physical Review D
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- 2022
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3. CAJAL enables analysis and integration of single-cell morphological data using metric geometry
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Govek, Kiya W., Nicodemus, Patrick, Lin, Yuxuan, Crawford, Jake, Saturnino, Artur B., Cui, Hannah, Zoga, Kristi, Hart, Michael P., and Camara, Pablo G.
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- 2023
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4. A roadmap for the Human Developmental Cell Atlas
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Haniffa, Muzlifah, Taylor, Deanne, Linnarsson, Sten, Aronow, Bruce J, Bader, Gary D, Barker, Roger A, Camara, Pablo G, Camp, J Gray, Chédotal, Alain, Copp, Andrew, Etchevers, Heather C, Giacobini, Paolo, Göttgens, Berthold, Guo, Guoji, Hupalowska, Ania, James, Kylie R, Kirby, Emily, Kriegstein, Arnold, Lundeberg, Joakim, Marioni, John C, Meyer, Kerstin B, Niakan, Kathy K, Nilsson, Mats, Olabi, Bayanne, Pe’er, Dana, Regev, Aviv, Rood, Jennifer, Rozenblatt-Rosen, Orit, Satija, Rahul, Teichmann, Sarah A, Treutlein, Barbara, Vento-Tormo, Roser, and Webb, Simone
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Medical Biotechnology ,Biomedical and Clinical Sciences ,Regenerative Medicine ,Stem Cell Research - Nonembryonic - Human ,Stem Cell Research ,Pediatric ,Stem Cell Research - Embryonic - Human ,Human Fetal Tissue ,Genetics ,Human Genome ,Good Health and Well Being ,Adult ,Animals ,Atlases as Topic ,Cell Culture Techniques ,Cell Movement ,Cell Survival ,Cell Tracking ,Cells ,Data Visualization ,Developmental Biology ,Embryo ,Mammalian ,Female ,Fetus ,Humans ,Imaging ,Three-Dimensional ,Information Dissemination ,Male ,Models ,Animal ,Organogenesis ,Organoids ,Stem Cells ,Human Cell Atlas Developmental Biological Network ,General Science & Technology - Abstract
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.
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- 2021
5. Spatio-Semantic ConvNet-Based Visual Place Recognition
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Camara, Luis G. and Přeučil, Libor
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Robotics ,I.2.10 ,I.4 ,I.5 - Abstract
We present a Visual Place Recognition system that follows the two-stage format common to image retrieval pipelines. The system encodes images of places by employing the activations of different layers of a pre-trained, off-the-shelf, VGG16 Convolutional Neural Network (CNN) architecture. In the first stage of our method and given a query image of a place, a number of top candidate images is retrieved from a previously stored database of places. In the second stage, we propose an exhaustive comparison of the query image against these candidates by encoding semantic and spatial information in the form of CNN features. Results from our approach outperform by a large margin state-of-the-art visual place recognition methods on five of the most commonly used benchmark datasets. The performance gain is especially remarkable on the most challenging datasets, with more than a twofold recognition improvement with respect to the latest published work., Comment: Accepted in Proceedings of the 2019 European Conference on Mobile Robots (ECMR 2019), Prague, Czech Republic, September 4-6, 2019
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- 2019
6. Spectral Simplicial Theory for Feature Selection and Applications to Genomics
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Govek, Kiya W., Yamajala, Venkata S., and Camara, Pablo G.
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Statistics - Machine Learning ,Computer Science - Machine Learning ,Quantitative Biology - Quantitative Methods - Abstract
The scale and complexity of modern data sets and the limitations associated with testing large numbers of hypotheses underline the need for feature selection methods. Spectral techniques rank features according to their degree of consistency with an underlying metric structure, but their current graph-based formulation restricts their applicability to point features. We extend spectral methods for feature selection to abstract simplicial complexes and present a general framework which can be applied to 2-point and higher-order features. Combinatorial Laplacian scores take into account the topology spanned by the data and reduce to the ordinary Laplacian score in the case of point features. We demonstrate the utility of spectral simplicial methods for feature selection with several examples of application to the analysis of gene expression and multi-modal genomic data. Our results provide a unifying perspective on topological data analysis and manifold learning approaches., Comment: 22 pages, 8 figures
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- 2018
7. Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma
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Aubin, Rachael G., Troisi, Emma C., Montelongo, Javier, Alghalith, Adam N., Nasrallah, Maclean P., Santi, Mariarita, and Camara, Pablo G.
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- 2022
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8. Inference of Ancestral Recombination Graphs through Topological Data Analysis
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Camara, Pablo G., Levine, Arnold J., and Rabadan, Raul
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Quantitative Biology - Quantitative Methods ,Mathematics - Algebraic Topology ,Quantitative Biology - Populations and Evolution - Abstract
The recent explosion of genomic data has underscored the need for interpretable and comprehensive analyses that can capture complex phylogenetic relationships within and across species. Recombination, reassortment and horizontal gene transfer constitute examples of pervasive biological phenomena that cannot be captured by tree-like representations. Starting from hundreds of genomes, we are interested in the reconstruction of potential evolutionary histories leading to the observed data. Ancestral recombination graphs represent potential histories that explicitly accommodate recombination and mutation events across orthologous genomes. However, they are computationally costly to reconstruct, usually being infeasible for more than few tens of genomes. Recently, Topological Data Analysis (TDA) methods have been proposed as robust and scalable methods that can capture the genetic scale and frequency of recombination. We build upon previous TDA developments for detecting and quantifying recombination, and present a novel framework that can be applied to hundreds of genomes and can be interpreted in terms of minimal histories of mutation and recombination events, quantifying the scales and identifying the genomic locations of recombinations. We implement this framework in a software package, called TARGet, and apply it to several examples, including small migration between different populations, human recombination, and horizontal evolution in finches inhabiting the Gal\'apagos Islands., Comment: 33 pages, 12 figures. The accompanying software, instructions and example files used in the manuscript can be obtained from https://github.com/RabadanLab/TARGet
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- 2015
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9. Flux-induced Soft Terms on Type IIB/F-theory Matter Curves and Hypercharge Dependent Scalar Masses
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Camara, Pablo G., Ibanez, Luis E., and Valenzuela, Irene
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
Closed string fluxes induce generically SUSY-breaking soft terms on supersymmetric type IIB orientifold compactifications with D3/D7 branes. This was studied in the past by inserting those fluxes on the DBI+CS actions for adjoint D3/D7 fields, where D7-branes had no magnetic fluxes. In the present work we generalise those computations to the phenomenologically more relevant case of chiral bi-fundamental fields laying at 7-brane intersections and F-theory local matter curves. We also include the effect of 7-brane magnetic flux as well as more general closed string backgrounds, including the effect of distant (anti-)D3-branes. We discuss several applications of our results. We find that squark/slepton masses become in general flux-dependent in F-theory GUT's. Hypercharge-dependent non-universal scalar masses with a characteristic sfermion hierarchy m_E^2 < m_L^2 < m_Q^2 < m_D^2 < m_U^2 are obtained. There are also flavor-violating soft terms both for matter fields living at intersecting 7-branes or on D3-branes at singularities. They point at a very heavy sfermion spectrum to avoid FCNC constraints. We also discuss the possible microscopic description of the fine-tuning of the EW Higgs boson in compactifications with a MSSM spectrum., Comment: 67 pages, 2 figures, 2 tables
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- 2014
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10. Brazilian License Plate Detection Using Histogram of Oriented Gradients and Sliding Windows
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Prates, R. F., Cámara-Chávez, G., Schwartz, William R., and Menotti, D.
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Due to the increasingly need for automatic traffic monitoring, vehicle license plate detection is of high interest to perform automatic toll collection, traffic law enforcement, parking lot access control, among others. In this paper, a sliding window approach based on Histogram of Oriented Gradients (HOG) features is used for Brazilian license plate detection. This approach consists in scanning the whole image in a multiscale fashion such that the license plate is located precisely. The main contribution of this work consists in a deep study of the best setup for HOG descriptors on the detection of Brazilian license plates, in which HOG have never been applied before. We also demonstrate the reliability of this method ensured by a recall higher than 98% (with a precision higher than 78%) in a publicly available data set.
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- 2014
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11. Single-cell transcriptomic analysis of adult mouse pituitary reveals sexual dimorphism and physiologic demand-induced cellular plasticity
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Ho, Yugong, Hu, Peng, Peel, Michael T., Chen, Sixing, Camara, Pablo G., Epstein, Douglas J., Wu, Hao, and Liebhaber, Stephen A.
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- 2020
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12. The String Origin of SUSY Flavor Violation
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Camara, Pablo G., Ibanez, Luis E., and Valenzuela, Irene
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We argue that in large classes of string compactifications with a MSSM-like structure substantial flavor violating SUSY-breaking soft terms are generically induced. We specify to the case of flavor dependent soft-terms in type IIB/F-theory SU(5) unified models, although our results can be easily extended to other settings. The Standard Model (SM) degrees of freedom reside in a local system of 7-branes wrapping a 4-fold S in the extra dimensions. It is known that in the presence of closed string 3-form fluxes SUSY-breaking terms are typically generated. We explore the generation dependence of these soft terms and find that non-universalities arise whenever the flux varies over the 4-fold S. These non-universalities are parametrically suppressed by (M_{GUT}/M_{Pl})^{1/3}. They also arise in the case of varying open string fluxes, in this case parametrically suppressed by \alpha_{GUT}^{1/2}. For a standard unification scheme with M_{GUT} = 10^{16} GeV and \alpha_{\rm GUT} = 1/24 these suppressions are very mild. Although limits from the kaon mass difference \Delta m_K are easily obeyed for squark masses above the present LHC limits, constraints from the CP-violation parameter \epsilon_K imply squark masses in the multi-TeV region. The constraints from BR(\mu \rightarrow e\gamma) turn out to be the strongest ones, with slepton masses of order ~10 TeV or heavier required to obey the experimental limits. These sfermion masses are consistent with the observed large value m_H ~ 126 GeV of the Higgs mass. We discuss under what conditions such strong limits may be relaxed allowing for SUSY particle production at LHC., Comment: 38 pages, 6 figures, 1 table; v2: references added
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- 2013
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13. The NMSSM with F-theory unified boundary conditions
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Aparicio, L., Camara, P. G., Cerdeno, D. G., Ibanez, L. E., and Valenzuela, I.
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We study the phenomenological viability of a constrained NMSSM with parameters subject to unified boundary conditions from F-theory GUTs. We find that very simple assumptions about modulus dominance SUSY breaking in F-theory unification lead to a predictive set of boundary conditions, consistent with all phenomenological constraints. The second lightest scalar Higgs H_2 can get a mass m_{H_2} ~ 125 GeV and has properties similar to the SM Higgs. On the other hand the lightest scalar H_1, with a dominant singlet component, would have barely escaped detection at LEP and could be observable at LHC as a peak in H_1 -> gamma gamma at around 100 GeV. The LSP is mostly singlino and is consistent with WMAP constraints due to coannihilation with the lightest stau, whose mass is in the range 100-250 GeV. Such light staus may lead to very characteristic signatures at LHC and be directly searched at linear colliders. In these models tan(beta) is large, of order 50, still the branching ratio for B_s -> mu+ mu- is consistent with the LHCb bounds and in many cases is also even smaller than the SM prediction. Gluinos and squarks have masses in the 2 - 3 TeV region and may be accessible at the LHC at 14 TeV. No large enhancement of the H_2 -> gamma gamma rate over that of the SM Higgs is expected., Comment: 46 pages, 13 figures. Typo in Table 4 corrected
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- 2012
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14. Zp charged branes in flux compactifications
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Berasaluce-González, Mikel, Cámara, Pablo G., Marchesano, Fernando, and Uranga, Ángel M.
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We consider 4d string compactifications in the presence of fluxes, and classify particles, strings and domain walls arising from wrapped branes which have charges conserved modulo an integer p, and whose annihilation is catalized by fluxes, through the Freed-Witten anomaly or its dual versions. The Z_p-valued strings and particles are associated to Z_p discrete gauge symmetries, which we show are realized as discrete subgroups of 4d U(1) symmetries broken by their Chern-Simons couplings to the background fluxes. We also describe examples where the discrete gauge symmetry group is actually non-Abelian. The Z_p-valued domain walls separate vacua which have different flux quanta, yet are actually equivalent by an integer shift of axion fields (or further string duality symmetries). We argue that certain examples are related by T-duality to the realization of discrete gauge symmetries and Z_p charges from torsion (co)homology. At a formal level, the groups classifying these discrete charges should correspond to a generalization of K-theory in the presence of general fluxes (and including fundamental strings and NS5-branes)., Comment: 30 pages + appendices, 5 figures; v2: Small comments added in sections 2.1 and 4. Version published in JHEP
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- 2012
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15. Non-Abelian discrete gauge symmetries in 4d string models
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Berasaluce-Gonzalez, Mikel, Camara, Pablo G., Marchesano, Fernando, Regalado, Diego, and Uranga, Angel M.
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We study the realization of non-Abelian discrete gauge symmetries in 4d field theory and string theory compactifications. The underlying structure generalizes the Abelian case, and follows from the interplay between gaugings of non-Abelian isometries of the scalar manifold and field identifications making axion-like fields periodic. We present several classes of string constructions realizing non-Abelian discrete gauge symmetries. In particular, compactifications with torsion homology classes, where non-Abelianity arises microscopically from the Hanany-Witten effect, or compactifications with non-Abelian discrete isometry groups, like twisted tori. We finally focus on the more interesting case of magnetized branes in toroidal compactifications and quotients thereof (and their heterotic and intersecting duals), in which the non-Abelian discrete gauge symmetries imply powerful selection rules for Yukawa couplings of charged matter fields. In particular, in MSSM-like models they correspond to discrete flavour symmetries constraining the quark and lepton mass matrices, as we show in specific examples., Comment: 58 pages; minor typos corrected and references added
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- 2012
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16. Massive wavefunctions, proton decay and FCNCs in local F-theory GUTs
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Camara, Pablo G., Dudas, Emilian, and Palti, Eran
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We study the coupling of MSSM fields to heavy modes through cubic superpotential interactions in F-theory SU(5) GUTs. The couplings are calculated by integrating the overlap of two massless and one massive wavefunctions. The overlap integral receives contributions from only a small patch around a point of symmetry enhancement thereby allowing the wavefunctions to be determined locally on flat space, drastically simplifying the calculation. The cubic coupling between two MSSM fields and one of the massive coloured Higgs triplets present in SU(5) GUTs is calculated using a local eight-dimensional SO(12) gauge theory. We find that for the most natural regions of local parameter space the coupling to the triplet is comparable to or stronger than in minimal four-dimensional GUTs thereby, for those regions, reaffirming or strengthening constraints from dimension-five proton decay. We also identify possible regions in local parameter space where the couplings to the lightest generations are substantially suppressed compared to minimal four-dimensional GUTs. We further apply our results and techniques to study other phenomenologically important operators arising from coupling to heavy modes. In particular we calculate within a toy model flavour non-universal soft masses induced by integrating out heavy modes which lead to FCNCs., Comment: 54 pages, 10 figures; v2: references added, minor corrections
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- 2011
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17. RR photons
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Camara, Pablo G., Ibañez, Luis E., and Marchesano, Fernando
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
Type II string compactifications to 4d generically contain massless Ramond-Ramond U(1) gauge symmetries. However there is no massless matter charged under these U(1)'s, which makes a priori difficult to measure any physical consequences of their existence. There is however a window of opportunity if these RR U(1)'s mix with the hypercharge $U(1)_Y$ (hence with the photon). In this paper we study in detail different avenues by which $U(1)_{RR}$ bosons may mix with D-brane U(1)'s. We concentrate on Type IIA orientifolds and their M-theory lift, and provide geometric criteria for the existence of such mixing, which may occur either via standard kinetic mixing or via the mass terms induced by St\"uckelberg couplings. The latter case is particularly interesting, and appears whenever D-branes wrap torsional $p$-cycles in the compactification manifold. We also show that in the presence of torsional cycles discrete gauge symmetries and Aharanov-Bohm strings and particles appear in the 4d effective action, and that type IIA St\"uckelberg couplings can be understood in terms of torsional (co)homology in M-theory. We provide examples of Type IIA Calabi-Yau orientifolds in which the required torsional cycles exist and kinetic mixing induced by mass mixing is present. We discuss some phenomenological consequences of our findings. In particular, we find that mass mixing may induce corrections relevant for hypercharge gauge coupling unification in F-theory SU(5) GUT's., Comment: 68 pages, 2 figures, 7 tables; v2: minor typos corrected, references modified
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- 2011
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18. U-dual fluxes and Generalized Geometry
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Aldazabal, G., Andres, E., Camara, P. G., and Graña, M.
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High Energy Physics - Theory - Abstract
We perform a systematic analysis of generic string flux compactifications, making use of Exceptional Generalized Geometry (EGG) as an organizing principle. In particular, we establish the precise map between fluxes, gaugings of maximal 4d supergravity and EGG, identifying the complete set of gaugings that admit an uplift to 10d heterotic or type IIB supegravity backgrounds. Our results reveal a rich structure, involving new deformations of 10d supergravity backgrounds, such as the RR counterparts of the $\beta$-deformation. These new deformations are expected to provide the natural extension of the $\beta$-deformation to full-fledged F-theory backgrounds. Our analysis also provides some clues on the 10d origin of some of the particularly less understood gaugings of 4d supergravity. Finally, we derive the explicit expression for the effective superpotential in arbitrary N = 1 heterotic or type IIB orientifold compactifications, for all the allowed fluxes., Comment: 58 pages, 6 tables
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- 2010
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19. Non-perturbative Vacuum Destabilization and D-brane Dynamics
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Camara, P. G., Condeescu, C., Dudas, E., and Lennek, M.
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High Energy Physics - Theory - Abstract
We analyze the process of string vacuum destabilization due to instanton induced superpotential couplings which depend linearly on charged fields. These non-perturbative instabilities result in potentials for the D-brane moduli and lead to processes of D-brane recombination, motion and partial moduli stabilization at the non-perturbative vacuum. By using techniques of D-brane instanton calculus, we explicitly compute this scalar potential in toroidal orbifold compactifications with magnetized D-branes by summing over the possible discrete instanton configurations. We illustrate explicitly the resulting dynamics in globally consistent models. These instabilities can have phenomenological applications to breaking hidden sector gauge groups, open string moduli stabilization and supersymmetry breaking. Our results suggest that breaking supersymmetry by Polonyi-like models in string theory is more difficult than expected., Comment: 61 pages, 6 figures, 5 tables; Minor corrections, version published in JHEP
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- 2010
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20. Holomorphic variables in magnetized brane models with continuous Wilson lines
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Camara, Pablo G., Condeescu, Cezar, and Dudas, Emilian
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High Energy Physics - Theory - Abstract
We analyze the action of the target-space modular group in toroidal type IIB orientifold compactifications with magnetized D-branes and continuous Wilson lines. The transformation of matter fields agree with that of twisted fields in heterotic compactifications, constituting a check of type I/heterotic duality. We identify the holomorphic N = 1 variables for these compactifications. Matter fields and closed string moduli are both redefined by open string moduli. The redefinition of matter fields can be read directly from the perturbative Yukawa couplings, whereas closed string moduli redefinitions are obtained from D-brane instanton superpotential couplings. The resulting expressions reproduce and generalize, in the presence of internal magnetic fields, previous results in the literature., Comment: 9 pages, no figures; v2: conventions for Wilson lines changed, major simplifications in expressions, discussions extended, typos corrected, some references added
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- 2009
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21. Open string wavefunctions in flux compactifications
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Camara, Pablo G. and Marchesano, Fernando
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High Energy Physics - Theory - Abstract
We consider compactifications of type I supergravity on manifolds with SU(3) structure, in the presence of RR fluxes and magnetized D9-branes, and analyze the generalized Dirac and Laplace-Beltrami operators associated to the D9-brane worldvolume fields. These compactifications are T-dual to standard type IIB toroidal orientifolds with NSNS and RR 3-form fluxes and D3/D7 branes. By using techniques of representation theory and harmonic analysis, the spectrum of open string wavefunctions can be computed for Lie groups and their quotients, as we illustrate with explicit twisted tori examples. We find a correspondence between irreducible unitary representations of the Kaloper-Myers algebra and families of Kaluza-Klein excitations. We perform the computation of 2- and 3-point couplings for matter fields in the above flux compactifications, and compare our results with those of 4d effective supergravity., Comment: 89 pages, 4 figures. v3: more typos corrected, version published in JHEP
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- 2009
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22. Flux algebra, Bianchi identities and Freed-Witten anomalies in F-theory compactifications
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Aldazabal, G., Camara, P. G., and Rosabal, J. A.
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High Energy Physics - Theory - Abstract
We discuss the structure of 4D gauged supergravity algebras corresponding to globally non-geometric compactifications of F-theory, admitting a local geometric description in terms of 10D supergravity. By starting with the well known algebra of gauge generators associated to non-geometric type IIB fluxes, we derive a full algebra containing all, closed RR and NSNS, geometric and non-geometric dual fluxes. We achieve this generalization by a systematic application of SL(2,Z) duality transformations and by taking care of the spinorial structure of the fluxes. The resulting algebra encodes much information about the higher dimensional theory. In particular, tadpole equations and Bianchi identities are obtainable as Jacobi identities of the algebra. When a sector of magnetized (p,q) 7-branes is included, certain closed axions are gauged by the U(1) transformations on the branes. We indicate how the diagonal gauge generators of the branes can be incorporated into the full algebra, and show that Freed-Witten constraints and tadpole cancellation conditions for (p,q) 7-branes can be described as Jacobi identities satisfied by the algebra mixing bulk and brane gauge generators., Comment: 50 pages. Section 5.2 corrected
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- 2008
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23. The structure of N=2 multi-instanton and string-loop corrections in toroidal orbifold models
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Camara, Pablo G.
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High Energy Physics - Theory - Abstract
We summarize the structure of N=2 multi-instanton and string loop corrections to the K\"ahler potential and the gauge kinetic function in type I toroidal orbifold models. For that aim, we exploit perturbative calculations of the physical gauge couplings on the heterotic dual, whenever such a perturbative description is available., Comment: Parallel talk at 34th International Conference on High Energy Physics (ICHEP08), Philadelphia, USA, July 2008. 5 pages
- Published
- 2008
24. Multi-instanton and string loop corrections in toroidal orbifold models
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Camara, P. G. and Dudas, E.
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High Energy Physics - Theory - Abstract
We analyze N=2 (perturbative and non-perturbative) corrections to the effective theory in type I orbifold models where a dual heterotic description is available. These corrections may play an important role in phenomenological scenarios. More precisely, we consider two particular compactifications: the Bianchi-Sagnotti-Gimon-Polchinski orbifold and a freely-acting Z_2 x Z_2 orbifold with N=1 supersymmetry and gauge group SO(q) x SO(32-q). By exploiting perturbative calculations of the physical gauge couplings on the heterotic side, we obtain multi-instanton and one-loop string corrections to the K\"ahler potential and the gauge kinetic function for these models. The non-perturbative corrections appear as sums over relevant Hecke operators, whereas the one-loop correction to the K\"ahler potential matches the expression proposed in [1,2]. We argue that these corrections are universal in a given class of models where target-space modular invariance (or a subgroup of it) holds., Comment: 37 pages, 3 figures
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- 2008
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25. No-scale supersymmetry breaking vacua and soft terms with torsion
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Cámara, Pablo G. and Graña, Mariana
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High Energy Physics - Theory - Abstract
We analyze the conditions to have no-scale supersymmetry breaking solutions of type IIA and IIB supergravity compactified on manifolds of SU(3)-structure. The supersymmetry is spontaneously broken by the intrinsic torsion of the internal space. For type IIB orientifolds with O9 and O5-planes the mass of the gravitino is governed by the torsion class W_1, and the breaking is mediated through F-terms associated to descendants of the original N=2 hypermultiplets. For type IIA orientifolds with O6-planes we find two families of solutions, depending on whether the breaking is mediated exclusively by hypermultiplets or by a mixture of hypermultiplets and vector multiplets, the latter case corresponding to a class of Scherk-Schwarz compactifications not dual to any geometric IIB setup. We compute the geometrically induced mu-terms for D5, D6 and D9-branes on twisted tori, and discuss the patterns of soft-terms which arise for pure moduli mediation in each type of breaking. As for D3 and D7-branes in presence of 3-form fluxes, the effective scalar potential turns out to possess interesting phenomenological properties., Comment: 44 pages; several minor corrections and added references
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- 2007
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26. String instantons, fluxes and moduli stabilization
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Camara, P. G., Dudas, E., Maillard, T., and Pradisi, G.
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High Energy Physics - Theory - Abstract
We analyze a class of dual pairs of heterotic and type I models based on freely-acting $\mathbb{Z}_2 \times \mathbb{Z}_2$ orbifolds in four dimensions. Using the adiabatic argument, it is possible to calculate non-perturbative contributions to the gauge coupling threshold corrections on the type I side by exploiting perturbative calculations on the heterotic side, without the drawbacks due to twisted moduli. The instanton effects can then be combined with closed-string fluxes to stabilize most of the moduli fields of the internal manifold, and also the dilaton, in a racetrack realization of the type I model., Comment: 1+49 pages
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- 2007
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27. Warped Supersymmetry Breaking
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Burgess, C. P., Camara, P. G., de Alwis, S. P., Giddings, S. B., Maharana, A., Quevedo, F., and Suruliz, K.
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High Energy Physics - Theory - Abstract
We address the size of supersymmetry-breaking effects within higher-dimensional settings where the observable sector resides deep within a strongly warped region, with supersymmetry breaking not necessarily localized in that region. Our particular interest is in how the supersymmetry-breaking scale seen by the observable sector depends on this warping. We obtain this dependence in two ways: by computing within the microscopic (string) theory supersymmetry-breaking masses in supermultiplets; and by investigating how warping gets encoded into masses within the low-energy 4D effective theory. We find that the lightest gravitino mode can have mass much less than the straightforward estimate from the mass shift of the unwarped zero mode. This lightest Kaluza-Klein excitation plays the role of the supersymmetric partner of the graviton and has a warped mass m_{3/2} proportional to e^A, with e^A the warp factor, and controls the size of the soft SUSY breaking terms. We formulate the conditions required for the existence of a description in terms of a 4D SUGRA formulation, or in terms of 4D SUGRA together with soft-breaking terms, and describe in particular situations where neither exist for some non-supersymmetric compactifications. We suggest that some effects of warping are captured by a linear $A$ dependence in the Kahler potential. We outline some implications of our results for the KKLT scenario of moduli stabilization with broken SUSY., Comment: 34 pages, 1 figure. v2 Further discussion of dual interpretation and gravitino mass
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- 2006
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28. More Dual Fluxes and Moduli Fixing
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Aldazabal, G., Camara, P. G., Font, A., and Ibanez, L. E.
- Subjects
High Energy Physics - Theory - Abstract
We generalize the recent proposal that invariance under T-duality leads to additional non-geometric fluxes required so that superpotentials in type IIA and type IIB orientifolds match. We show that invariance under type IIB S-duality requires the introduction of a new set of fluxes leading to further superpotential terms. We find new classes of N=1 supersymmetric Minkowski vacua based on type IIB toroidal orientifolds in which not only dilaton and complex moduli but also Kahler moduli are fixed. The chains of dualities relating type II orientifolds to heterotic and M-theory compactifications suggests the existence of yet further flux degrees of freedom. Restricting to a particular type IIA/IIB or heterotic compactification only some of these degrees of freedom have a simple perturbative and/or geometric interpretation., Comment: 50 pages, Latex file, no figures
- Published
- 2006
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29. Fluxes, moduli fixing and MSSM-like vacua in Type IIA String Theory
- Author
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Camara, Pablo G.
- Subjects
High Energy Physics - Theory - Abstract
We review some of the features of Type IIA compactifications in the presence of fluxes. In particular, the case of $T^6/(\Omega (-1)^{F_L} \sigma)$ orientifolds with RR, NS and metric fluxes is considered. This has revealed to possess remarkable properties such as vacua with all the closed string moduli stabilized, null or negative contributions to the RR tadpoles or supersymmetry on the branes enforced by the closed string background. In this way, Type IIA compactifications with non trivial fluxes seem to constitute a new window into the building of semi-realistic models in String Theory., Comment: 8 pages; Contribution to the proceedings of the RTN workshop "Constituents, Fundamental Forces and Symmetries of the Universe", Corfu, Greece, 20-26 September 2005; corrected typos, added references
- Published
- 2005
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30. Fluxes, moduli fixing and MSSM-like vacua in a simple IIA orientifold
- Author
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Camara, P. G., Font, A., and Ibanez, L. E.
- Subjects
High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We study the effects of adding RR, NS and metric fluxes on a T^6/(\Omega (-1)^{F_L} I_3) Type IIA orientifold. By using the effective flux-induced superpotential we obtain Minkowski or AdS vacua with broken or unbroken supersymmetry. In the Minkowski case some combinations of real moduli remain undetermined, whereas all can be stabilized in the AdS solutions. Many flux parameters are available which are unconstrained by RR tadpole cancellation conditions allowing to locate the minima at large volume and small dilaton. We also find that in AdS supersymmetric vacua with metric fluxes, the overall flux contribution to RR tadpoles can vanish or have opposite sign to that of D6-branes, allowing for new model-building possibilities. In particular, we construct the first N=1 supersymmetric intersecting D6-brane models with MSSM-like spectrum and with all closed string moduli stabilized. Some axion-like fields remain undetermined but they are precisely required to give St\"uckelberg masses to (potentially anomalous) U(1) brane fields. We show that the cancellation of the Freed-Witten anomaly guarantees that the axions with flux-induced masses are orthogonal to those giving masses to the U(1)'s. Cancellation of such anomalies also guarantees that the D6-branes in our N=1 supersymmetric AdS vacua are calibrated so that they are forced to preserve one unbroken supersymmetry., Comment: 61 pages, Latex, v2: added references, v3: minor corrections
- Published
- 2005
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31. Flux-induced SUSY-breaking soft terms on D7-D3 brane systems
- Author
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Camara, P. G., Ibanez, L. E., and Uranga, A. M.
- Subjects
High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We study the effect of RR and NSNS 3-form fluxes on the effective action of the worldvolume fields of Type IIB D7/D3-brane configurations. The D7-branes wrap 4-cycles on a local Calabi-Yau geometry. This is an extension of previous work on hep-th/0311241, where a similar analysis was applied to the case of D3-branes. Our present analysis is based on the D7- and D3-brane Dirac-Born-Infeld and Chern-Simons actions, and makes full use of the R-symmetries of the system, which allow us to compute explicitly results for the fields lying at the D3-D7 intersections. A number of interesting new properties appear as compared to the simpler case of configurations with only D3-branes. As a general result one finds that fluxes stabilize some or all of the D7-brane moduli. We argue that this is important for the problem of stabilizing Kahler moduli through non-perturbative effects in KKLT-like vacua. We also show that (0,3) imaginary self-dual fluxes, which lead to compactifications with zero vacuum energy, give rise to SUSY-breaking soft terms including gaugino and scalar masses, and trilinear terms. Particular examples of chiral MSSM-like models of this class of vacua, based on D3-D7 brane systems at orbifold singularities are presented., Comment: 58 pages, no figures; v2: numerical factor in section 7.2 corrected
- Published
- 2004
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32. Flux-induced SUSY-breaking soft terms
- Author
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Camara, P. G., Ibanez, L. E., and Uranga, A. M.
- Subjects
High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
We describe the computation of SUSY-breaking terms on a D3-brane in a quite general type IIB supergravity background. We apply it to study the SUSY-breaking induced on the D3-brane world-volume by the presence of NSNS and RR 3-form fluxes. We provide explicit general formulae for the SUSY-breaking soft terms valid for the different types of fluxes, leading to different patterns of soft terms. Imaginary anti-selfdual fluxes with G_3 a pure (3,0)-form lead to soft terms corresponding to dilaton-dominated SUSY-breaking. More general SUSY-breaking patterns are discussed, arising from more general fluxes, or from distant anti-D3-branes. The known finiteness properties of dilaton-dominated soft terms are understood in terms of holography. The above results are interpreted in the context of the 4d effective supergravity theory, where flux components correspond to auxiliary fields of e.g. the 4d dilaton and overall volume modulus. We present semirealistic Type IIB orientifold examples with (meta)stable vacua leading to non-vanishing soft terms of the dilaton-domination type. Such models have many of the ingredients of the recent construction of deSitter vacua in string theory. We finally explore possible phenomenological applications of this form of SUSY-breaking, where we show that soft terms are of order M_s^2/M_p. Thus a string scale of order M_s=10^{10} GeV, and compactification scale three orders of magnitude smaller could explain the smallness of the weak scale versus the Planck mass., Comment: 58 pages, 1 eps figure. Minor corrections, references added
- Published
- 2003
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33. Mechanically driven millimeter source of nanosecond X-ray pulses
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Camara, C. G., Escobar, J. V., Hird, J. R., and Putterman, S. J.
- Subjects
Physics ,Physics, general ,Engineering, general ,Optics, Optoelectronics, Plasmonics and Optical Devices ,Quantum Optics ,Laser Technology, Photonics ,Physical Chemistry - Abstract
The emission of nanosecond pulses of ≈20 keV photons having a total energy of GeVs which are generated by peeling millimeter wide strips of pressure sensitive adhesive (PSA) tape in a partial pressure of air (≈10−3 Torr) is demonstrated. The X-ray spectrum is similar to that obtained by peeling much wider bands of PSA, implying that the characteristic length for the sequence of processes that govern this phenomenon is less than 1 mm. These experiments demonstrate that MEMS-type X-ray generators are technologically feasible.
- Published
- 2010
34. Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics.
- Author
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Kiryluk, Krzysztof, Bomback, Andrew S., Cheng, Yim-Ling, Xu, Katherine, Camara, Pablo G., Rabadan, Raul, Sims, Peter A., and Barasch, Jonathan
- Abstract
Acute kidney injury (AKI) currently is diagnosed by a temporal trend of a single blood analyte: serum creatinine. This measurement is neither sensitive nor specific to kidney injury or its protean forms. Newer biomarkers, neutrophil gelatinase-associated lipocalin (NGAL, Lipocalin 2, Siderocalin), or kidney injury molecule-1 (KIM-1, Hepatitis A Virus Cellular Receptor 1), accelerate the diagnosis of AKI as well as prospectively distinguish rapidly reversible from prolonged causes of serum creatinine increase. Nonetheless, these biomarkers lack the capacity to subfractionate AKI further (eg, sepsis versus ischemia versus nephrotoxicity from medications, enzymes, or metals) or inform us about the primary and secondary sites of injury. It also is unknown whether all nephrons are injured in AKI, whether all cells in a nephron are affected, and whether injury responses can be stimulus-specific or cell type-specific or both. In this review, we summarize fully agnostic tissue interrogation approaches that may help to redefine AKI in cellular and molecular terms, including single-cell and single-nuclei RNA sequencing technology. These approaches will empower a shift in the current paradigm of AKI diagnosis, classification, and staging, and provide the renal community with a significant advance toward precision medicine in the analysis AKI. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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35. Spatiotemporal genomic architecture informs precision oncology in glioblastoma
- Author
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Lee, Jin-Ku, Wang, Jiguang, Sa, Jason K, Ladewig, Erik, Lee, Hae-Ock, Lee, In-Hee, Kang, Hyun Ju, Rosenbloom, Daniel S, Camara, Pablo G, Liu, Zhaoqi, van Nieuwenhuizen, Patrick, Jung, Sang Won, Choi, Seung Won, Kim, Junhyung, Chen, Andrew, Kim, Kyu-Tae, Shin, Sang, Seo, Yun Jee, Oh, Jin-Mi, Shin, Yong Jae, Park, Chul-Kee, Kong, Doo-Sik, Seol, Ho Jun, Blumberg, Andrew, Lee, Jung-Il, Iavarone, Antonio, Park, Woong-Yang, Rabadan, Raul, and Nam, Do-Hyun
- Abstract
Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies. However, this proposition is complicated by spatial and temporal heterogeneity. Here we study genomic and expression profiles across 127 multisector or longitudinal specimens from 52 individuals with glioblastoma (GBM). Using bulk and single-cell data, we find that samples from the same tumor mass share genomic and expression signatures, whereas geographically separated, multifocal tumors and/or long-term recurrent tumors are seeded from different clones. Chemical screening of patient-derived glioma cells (PDCs) shows that therapeutic response is associated with genetic similarity, and multifocal tumors that are enriched with PIK3CA mutations have a heterogeneous drug-response pattern. We show that targeting truncal events is more efficacious than targeting private events in reducing the tumor burden. In summary, this work demonstrates that evolutionary inference from integrated genomic analysis in multisector biopsies can inform targeted therapeutic interventions for patients with GBM.
- Published
- 2017
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36. The Adjunctive Use of Mitomycin C in Dacryocystorhinostomy.
- Author
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Cohen, Adam J., Mercandetti, Michael, Brazzo, Brian G., Camara, Jorge G., Yasay-Luis, Mary Ann, and Enriquez, Irene D.
- Published
- 2006
- Full Text
- View/download PDF
37. Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination
- Author
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Camara, Pablo G., Rosenbloom, Daniel I.S., Emmett, Kevin J., Levine, Arnold J., and Rabadan, Raul
- Abstract
Meiotic recombination is a fundamental evolutionary process driving diversity in eukaryotes. In mammals, recombination is known to occur preferentially at specific genomic regions. Using topological data analysis (TDA), a branch of applied topology that extracts global features from large data sets, we developed an efficient method for mapping recombination at fine scales. When compared to standard linkage-based methods, TDA can deal with a larger number of SNPs and genomes without incurring prohibitive computational costs. We applied TDA to 1,000 Genomes Project data and constructed high-resolution whole-genome recombination maps of seven human populations. Our analysis shows that recombination is generally under-represented within transcription start sites. However, the binding sites of specific transcription factors are enriched for sites of recombination. These include transcription factors that regulate the expression of meiosis- and gametogenesis-specific genes, cell cycle progression, and differentiation blockage. Additionally, our analysis identifies an enrichment for sites of recombination at repeat-derived loci matched by piwi-interacting RNAs.
- Published
- 2016
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38. Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation
- Author
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Govek, Kiya W., Chen, Sixing, Sgourdou, Paraskevi, Yao, Yao, Woodhouse, Steven, Chen, Tingfang, Fuccillo, Marc V., Epstein, Douglas J., and Camara, Pablo G.
- Abstract
The thalamus is the principal information hub of the vertebrate brain, with essential roles in sensory and motor information processing, attention, and memory. The complex array of thalamic nuclei develops from a restricted pool of neural progenitors. We apply longitudinal single-cell RNA sequencing and regional abrogation of Sonic hedgehog (Shh) to map the developmental trajectories of thalamic progenitors, intermediate progenitors, and post-mitotic neurons as they coalesce into distinct thalamic nuclei. These data reveal that the complex architecture of the thalamus is established early during embryonic brain development through the coordinated action of four cell differentiation lineages derived from Shh-dependent and -independent progenitors. We systematically characterize the gene expression programs that define these thalamic lineages across time and demonstrate how their disruption upon Shh depletion causes pronounced locomotor impairment resembling infantile Parkinson’s disease. These results reveal key principles of thalamic development and provide mechanistic insights into neurodevelopmental disorders resulting from thalamic dysfunction.
- Published
- 2022
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39. A triboelectric closed loop band system for the generation of x-rays
- Author
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Khounsary, Ali M., MacDonald, Carolyn A., Van Cleve, E., Lucas, B., Ganlieli, Z., Wong, E. W., Cortes, P., Mehta, N., Cuadra, D., Fong, J., Hansen, S., Kotowski, A., and Camara, C. G.
- Published
- 2015
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40. Ocular Findings in Volcanic Fog Induced Conjunctivitis.
- Author
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Camara, Jorge G. and Lagunzad, John Kenneth D.
- Subjects
EYE diseases ,CONJUNCTIVA diseases ,RESPIRATORY diseases - Abstract
Objective: To describe the ocular signs and symptoms of patients complaining of eye irritation due to volcanic fog (vog). Methods: The study utilized a non-comparative, retrospective chart review of 30 patients who had a chief complaint of eye irritation, which the subjects attributed to vog. Ocular signs and symptoms are described and related to the ambient concentration of sulfur dioxide (SO
2 ), particulate matter sized 2.5 microns (PM2.5 ), and vog visibility in O'ahu during the period of the study. Results: Ocular signs noted were conjunctival injection (100%), clear mucous discharge (100%), papillary reaction (100%), punctal edema (80%), eyelid swelling (73.3%) and chemosis (63.3%). Ocular symptoms were itchiness (100%), foreign body sensation (100%), tearing (96.6%) and burning sensation (90%). All patients had concurrent respiratory symptoms. During the period of study, the highest 24-hour average concentration of particulate matter sized 2.5 microns (PM2.5 ) was 49.04 µg/m³ and vog was visually present. Conclusions: Patients complaining of eye irritation due to vog have observable ocular signs and symptoms. [ABSTRACT FROM AUTHOR]- Published
- 2011
41. Use of Adhesive Tape for Temporary Management of Inturned Upper Eyelid EyelashesAdhesive Tape for Inturned Upper Eyelid Eyelashes
- Author
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Camara, Jorge G., Chan, Megan Q., Ruszkowski, Joseph M., Worak, Sandra R., and Peralta, Rizalina V.
- Abstract
OBJECTIVE To evaluate the efficacy of adhesive tape for temporary management of inturned upper eyelid eyelashes. METHODS In a prospective, consecutive, comparative, nonrandomized, interventional case series, 50 patients (100 eyes) had inturned eyelashes with at least 1 of 3 symptoms: foreign body sensation, itchiness, and tearing. Transpore tape was applied to the right upper eyelid of each patient; the left eye was used as a control. A questionnaire was used to assess relief or persistence of the symptoms before, during, and after tape adhesion. RESULTS Analysis of variance showed a significant difference between the study and control groups (P = .002). Tukey honestly significant difference analysis revealed a significant difference in symptoms before and during tape adhesion and a significant difference during and after tape adhesion. Symptoms in the control eye remained unchanged. CONCLUSION Use of adhesive tape can be an effective temporary measure for relief of symptoms of inturned upper eyelid eyelashes.
- Published
- 2012
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42. Acaricidal Activity and Essential Oil Composition of Petiveria alliaceaL. from Pernambuco (Northeast Brazil)
- Author
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Neves, I.I. de A., da Camara, C.A. G., de Oliviera, J.C. S., and de Almeida, A.V.
- Abstract
AbstractThe essential oils of the leaves, stems, flowers and roots of Petiveria alliaceaL., growing wild in Limoeiro, Pernambuco, were investigated by combinations of GC and GC/MS. Eighteen components were identified in the oils from leaves, stems, flowers and roots, comprising 87.1%, 93.1%, 94.9%, and 96.4% of the oils, respectively. Petiveria alliaceaproduced an oil dominated by benzenoids and polysulphide compounds, with the principal components being benzyl alcohol (46.6% in the root oil); carvacrol (50.9% in the leaf oil, 48.3% in the stem oil and 29.7% in the flower oil); (Z)-3-hexenyl benzoate (18.6% in the leaf oil, 9.5% in the stem oil and 30.5% in the flower oil) and dibenzyl disulphide (17.6% in the leaf oil, 23.1% in the stem oil, 15.7% in the flower oil and 19.1% in the root oil). The acaricidal activities of the oils against Tetranychus urticaewere also investigated. The lowest values of LC50 were observed for the flower oil (0.16 µL/L of air) and root (0.12µL/L of air), which did not differ significantly between themselves.
- Published
- 2011
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43. Volatile Constituents of the Fruits of Clusia nemorasaG.Mey. from Different Region of Atlantic Coast restingas of Pernambuco (Northeast of Brazil)
- Author
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de Oliveira, JoséC. S., Neves, IlzenaydeA., da Camara, ClaudioA. G., and Schwartz, ManfredO. E.
- Abstract
AbstractThe volatile components of the fruits from nine collections of Clusia nemorosaG. Mey. from two municipalities (Tamandaré: T1–3 and Cabo de Santo Agostinho: N1–3; G1–3) of the coastal region of Pernambuco, Northeast of Brazil, in two kind of soil, rocky rich in iron (N1–3) and sandy clays (T1–3 and G1–3), were analyzed by GC and GC/MS. The isolated oils were obtained in similar yields, 0.1–0.3 % (w/w) and 0.1–0.2% (w/w) in the samples from Taman- daré (T1–3) and Fortress Nazaré (N1–3) and in the samples from Gaibú (G1–3), respectively. The oil samples can be characterized by the abundance of sesquiterpene hydrocarbons, while the percentage of oxygenated sesquiterpenes was higher in the samples collected in Tamandaré (T1–3: 20.4—22.0%) and Gaibú (G1–3: 17.6–20.4%). Monoterpenes hydrocarbons were totally absent in all samples. All samples showed β-caryophyllene (37.3–48.6%) as the principal component. Based on the information of other major components, two subtypes of C. nemorosagrowing wild in Pernambuco, Brazil, can be established
- Published
- 2008
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- View/download PDF
44. Chemical Composition of the Leaf Oils of Lippia gracilisSchauer from two Localities of Pernambuco
- Author
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Neves, IlzenaydeA., de Oliveira, JoséC. S., da Camara, ClaudioA. G., and Schwartz, ManfredO. E.
- Abstract
AbstractThe chemical compositions of the essential oils from the leaves collected of Lippia gracilisSchauer at two localities in the bioma caatinga of Pernambuco were analyzed by GC and GC/MS, where a total of thirty-six compounds were identified in the oils from all the samples. The chemical profiles of samples from the same locations were the same having only relative changes in composition. But the chemical compositions of oils collected in the vicinity of Buique in the Agreste of Pernambuco were quite different from the ones collected in Ouricuri in the Sertão. The main components identified in samples from Buique were carvacrol (36.4–45.0%) and p-cymene (18.1–26.2%), while thymol (37.4%), γ-terpinene (14.9–20.5%) and 4-methoxy-acetophenone (10.1–12.4%) were the major components found in the specimen collected in Buique.
- Published
- 2008
- Full Text
- View/download PDF
45. Composition and Insecticidal Activity of the Essential Oil of Croton grewioidesBaill. against Mexican Bean Weevil (Zabrotes subfasciatusBoheman)
- Author
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Silva, CléiaG. V., Zago, HugoB., Júnior, HugoJ. G. S., da Camara, ClaudioA. G., de Oliveira, JoséVargas, Barros, Reginaldo, Schwartz, ManfredO. E., and Lucena, MariaF. A.
- Abstract
AbstractThe essential oils of leaves and stems of Croton grewioidesBaill. of the “agreste” region of Pernambuco, Brazil, were obtained by hydrodistillation and analyzed by GC and GC/MS. Twenty-two components were identified, which represented 99.8% and 98.6% of the total constituents in the leaf and stem oil, respectively. Croton grewioidesproduced an oil with a predominance of phenylpropanoid compounds, whose principal component was (E)-anethole (65.5% in the leaf and 47.8% in the stem). Other major components found in the leaf oil were methyl eugenol (10.6%) and (E)-methyl isoeugenol (4.7%). Other components identified in the stem oil were (E)-methyl isoeugenol (30.0%), cadalene (8.4%) and methyl eugenol (4.6%). The insecticidal activity of C. grewioideswas evaluated against Mexican bean weevils, Zabrotes subfaciatus(Boheman) resulting in a LC50 for the leaf oil, which was 3.4 times less than that obtained from the stem oil.
- Published
- 2008
- Full Text
- View/download PDF
46. Volatile Constituents of the Stem and Leaves of CordiaSpecies from Mountain Forests of Pernambuco (North-eastern Brazil)
- Author
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de Oliveira, JoséC. S., da Camara, ClaudioA. G., and Schwartz, ManfredO. E.
- Abstract
AbstractEssential oils obtained by hydrodistillation from stem and leaves of Cordia globosa(Jacq.) Hmb., Bonpl. et Kunth and Cordia curassavica(Jacq.) Roem. et Schult. were analyzed by GC/FID and GC/MS. The oil yield of C. globosaand C. curassavicawas 0.5% and 1.1% for the stem and 0.6% and 1.0% for the leaves, respectively. Although they belong to the same genus, the chemical composition of the oils from two Cordiaspecies was very different. The main components in the oil of C. globosawere: 1-endo-bourbonanol (20.2% in stem) and linalyl butyrate (14.7% in stem); β-caryophyllene (39.0% in leaves) and α-humulene (12.1% in leaves). Spathulenol (27.1% in stem), trans-sesquisabinene hydrate (11.0% in stem), viridiflorol (10.7% in stem), β-phellandrene (25.3% in leaves), cubebol (23.9% in leaves) and α-pinene (10.4 % in leaves) were the main constituents of the oils of C. curassavica.
- Published
- 2007
- Full Text
- View/download PDF
47. Use of the Diode Laser With Intraoperative Mitomycin C in Endocanalicular Laser Dacryocystorhinostomy
- Author
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Henson, Raoul D., Henson, Ruben G., Cruz, Hernando L., and Camara, Jorge G.
- Abstract
To determine the safety and efficacy of the diode laser with intraoperative mitomycin C in endocanalicular laser dacryocystorhinostomy (ECL-DCR).
- Published
- 2007
- Full Text
- View/download PDF
48. The Use of a Computer-Assisted Image-Guided System (InstaTrak) in Orbital Surgery
- Author
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Camara, Jorge G., Nguyen, Ly T., Fernandez-Suntay, Jessica P., Nardin, George F., and Sua, Alex S.
- Abstract
To assess the usefulness of a computer-assisted image-guided system (CAIGS) as an intraoperative anatomical guide in performing orbital surgery.
- Published
- 2001
49. Endonasal dacryocystorhinostomy
- Author
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Woog, J. J., Kennedy, R. H., Custer, P. L., Kaltreider, S. A., Meyer, D. R., and Camara, J. G.
- Published
- 2001
- Full Text
- View/download PDF
50. The Safety and Efficacy of Mitomycin C in Endonasal Endoscopic Laser-Assisted Dacryocystorhinostomy
- Author
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Camara, Jorge G., Bengzon, Alfonso U., and Henson, Raoul D.
- Abstract
The adjunctive use of mitomycin C (MMC) in glaucoma and pterygium surgery has been widely published, but there has not been any large long-term study of its use in endonasal endoscopic laser-assisted dacryocystorhinostomy (ELA-DCR). The purpose of this study was to examine the safety and efficacy of the adjunctive use of MMC in this procedure.
- Published
- 2000
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