1. Neonatal bloodstream infections in a pediatric hospital in Vietnam: a cohort study
- Author
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Freddy Karup Pedersen, Gorm Greisen, Jorgen Prag, Cam N Phuong, Than Duc, Alexandra Kruse, Lone Graff Stensballe, Jørgen A. L. Kurtzhals, and Do Huu Thieu Chuong
- Subjects
Male ,Klebsiella ,medicine.medical_specialty ,medicine.drug_class ,Gram-positive bacteria ,Antibiotics ,Bacteremia ,Microbial Sensitivity Tests ,medicine.disease_cause ,Gram-Positive Bacteria ,Severity of Illness Index ,Pediatric hospital ,Internal medicine ,Intensive Care Units, Neonatal ,Sepsis ,Drug Resistance, Bacterial ,Gram-Negative Bacteria ,medicine ,Humans ,Blood culture ,Prospective Studies ,Sex Distribution ,Intensive care medicine ,Child ,Gram-Positive Bacterial Infections ,biology ,medicine.diagnostic_test ,business.industry ,Streptococcus ,Incidence ,Infant, Newborn ,Infant ,Acinetobacter ,biology.organism_classification ,bacterial infections and mycoses ,Hospitals, Pediatric ,Survival Analysis ,Anti-Bacterial Agents ,Infectious Diseases ,Vietnam ,Pediatrics, Perinatology and Child Health ,Female ,business ,Gram-Negative Bacterial Infections ,human activities ,Cohort study - Abstract
Septicemia and bloodstream infections (BSIs) are major causes of neonatal morbidity and mortality in developing countries. We prospectively recorded all positive blood cultures (BSI) among neonates admitted consecutively to a tertiary pediatric hospital in Vietnam during a 12-month period. Among 5763 neonates, 2202 blood cultures were performed, of which 399 were positive in 385 neonates. Among these, 64 died, 62 in relation to septicemia. Of the BSI isolates, 56% was known pathogenic and 48% was gram-negative bacteria, most frequently Klebsiella spp. (n = 78), Acinetobacter spp. (n = 58) and Escherichia coli (n = 21). Only three Streptococcus spp. were identified, none group B. Resistance against antibiotics applied was common. The mortality was highest in neonates with gram-negative BSI compared with no confirmed BSI and gram-positive BSI (P
- Published
- 2013