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7 results on '"Calzatini, F."'

1. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author

Camandona, F, Vaccari, L, Travan, L, Maso, G, Stampalija, T, Zanazzo, L, Pisana, P, Driul, L, Barbui, E, Caissutti, C, Valente, E, Ricchi, A, Bettiga, E, Piccolo, E, Pati, M, Pedori, S, Antonazzo, P, Sottile, G, Lo Faro, F, Tini, A, Massacesi, M, Rapisarda, C, Vivirito, G, Pinna, G, D'Anna, M, Klein, L, Bucolo, A, D'Anna, R, Monaco, C, La Ferrera, G, Capobianco, G, Olzai, M, Angioni, S, D'Alterio, M, Serravalle, P, Vicquery, C, Scalchi, S, Morando, C, Meneghin, M, Scapolan, C, Maggino, T, Guarinoni, B, Cristina Napolitano, G, De Vita, M, Di Carlo, C, Interlandi, F, Bisceglia, M, Michelangelo, B, Arnulfo, A, Finale, E, Marozio, L, Natali, I, Grazia, S, Staffler, A, Tarani, L, Coriale, G, Messina, M, D'Angelo, A, Bonito, M, Haass, C, Capasso, L, Raimondi, F, De Bernardo, G, Iacobelli, P, Spadarella, S, Enrica, M, Rabuano, R, Calzatini, F, Bossi, A, Aversa, S, Prefumo, F, Bellan, C, Leone, G, Ciammella, M, Von-Wunster, S, Liguori, A, Ornaghi, S, Fumagalli, S, Sanguineti, F, Gianola, G, Cagnacci, A, Amidani, A, Sisto, A, Di Marcello, F, Santillo, V, Di Bartolomeo, C, Gerli, S, Cagnoli, G, Petrisano, M, Pesce, S, Di Lascio, N, Falvino, S, Appio, P, Targiani, V, Cavaliere, A, Turrini, I, Belli, G, Beatrice, G, Florio, P, Innocenti, E, Magi, L, Civitelli, F, Nappi, L, Sorrentino, F, Silvestris, T, Indrio, F, Laforgia, N, Rizzo, V, La Rocca, M, Pradal, U, Memo, L, Diaz, C, Riscica, P, Bazzo, S, La Maida, N, Di Giorgi, A, Pellegrini, M, Ceccanti, M, Caruso, S, Ricci, G, Neri, I, Lana, S, Minutillo, A, Berretta, P, Busardo, F, Pichini, S, Camandona F., Vaccari L., Travan L., Maso G., Stampalija T., Zanazzo L., Pisana P., Driul L., Barbui E., Caissutti C., Valente E., Ricchi A., Bettiga E., Piccolo E., Pati M., Pedori S., Antonazzo P., Sottile G., Lo Faro F., Tini A., Massacesi M., Rapisarda C., Vivirito G., Pinna G., D'anna M., Klein L., Bucolo A., D'Anna R., Monaco C., La Ferrera G., Capobianco G., Olzai M. G., Angioni S., D'Alterio M. N., Serravalle P., Vicquery C., Scalchi S., Morando C., Meneghin M., Scapolan C., Maggino T., Guarinoni B., Cristina Napolitano G. M., De Vita M. G., Di Carlo C., Interlandi F., Bisceglia M., Michelangelo B., Arnulfo A., Finale E., Marozio L., Natali I., Grazia S. M., Staffler A., Tarani L., Coriale G., Messina M. P., D'Angelo A., Bonito M., Haass C., Capasso L., Raimondi F., De Bernardo G., Iacobelli P., Spadarella S., Enrica M., Rabuano R., Calzatini F., Bossi A., Aversa S., Prefumo F., Bellan C., Leone G., Ciammella M., Von-Wunster S., Liguori A., Ornaghi S., Fumagalli S., Sanguineti F., Gianola G., Cagnacci A., Amidani A., Sisto A., Di Marcello F., Santillo V., Di Bartolomeo C., Gerli S., Cagnoli G., Petrisano M., Pesce S., Di Lascio N., Falvino S., Appio P., Targiani V., Cavaliere A. F., Turrini I., Belli G., Beatrice G., Florio P., Innocenti E. D., Magi L., Civitelli F., Nappi L., Sorrentino F., Silvestris T., Indrio F., Laforgia N., Rizzo V., La Rocca M., Pradal U., Memo L., Diaz C., Riscica P., Bazzo S., La Maida N., Di Giorgi A., Pellegrini M., Ceccanti M., Caruso S., Ricci G., Neri I., Lana S., Minutillo A., Berretta P., Busardo F. P., Pichini S., Camandona, F, Vaccari, L, Travan, L, Maso, G, Stampalija, T, Zanazzo, L, Pisana, P, Driul, L, Barbui, E, Caissutti, C, Valente, E, Ricchi, A, Bettiga, E, Piccolo, E, Pati, M, Pedori, S, Antonazzo, P, Sottile, G, Lo Faro, F, Tini, A, Massacesi, M, Rapisarda, C, Vivirito, G, Pinna, G, D'Anna, M, Klein, L, Bucolo, A, D'Anna, R, Monaco, C, La Ferrera, G, Capobianco, G, Olzai, M, Angioni, S, D'Alterio, M, Serravalle, P, Vicquery, C, Scalchi, S, Morando, C, Meneghin, M, Scapolan, C, Maggino, T, Guarinoni, B, Cristina Napolitano, G, De Vita, M, Di Carlo, C, Interlandi, F, Bisceglia, M, Michelangelo, B, Arnulfo, A, Finale, E, Marozio, L, Natali, I, Grazia, S, Staffler, A, Tarani, L, Coriale, G, Messina, M, D'Angelo, A, Bonito, M, Haass, C, Capasso, L, Raimondi, F, De Bernardo, G, Iacobelli, P, Spadarella, S, Enrica, M, Rabuano, R, Calzatini, F, Bossi, A, Aversa, S, Prefumo, F, Bellan, C, Leone, G, Ciammella, M, Von-Wunster, S, Liguori, A, Ornaghi, S, Fumagalli, S, Sanguineti, F, Gianola, G, Cagnacci, A, Amidani, A, Sisto, A, Di Marcello, F, Santillo, V, Di Bartolomeo, C, Gerli, S, Cagnoli, G, Petrisano, M, Pesce, S, Di Lascio, N, Falvino, S, Appio, P, Targiani, V, Cavaliere, A, Turrini, I, Belli, G, Beatrice, G, Florio, P, Innocenti, E, Magi, L, Civitelli, F, Nappi, L, Sorrentino, F, Silvestris, T, Indrio, F, Laforgia, N, Rizzo, V, La Rocca, M, Pradal, U, Memo, L, Diaz, C, Riscica, P, Bazzo, S, La Maida, N, Di Giorgi, A, Pellegrini, M, Ceccanti, M, Caruso, S, Ricci, G, Neri, I, Lana, S, Minutillo, A, Berretta, P, Busardo, F, Pichini, S, Camandona F., Vaccari L., Travan L., Maso G., Stampalija T., Zanazzo L., Pisana P., Driul L., Barbui E., Caissutti C., Valente E., Ricchi A., Bettiga E., Piccolo E., Pati M., Pedori S., Antonazzo P., Sottile G., Lo Faro F., Tini A., Massacesi M., Rapisarda C., Vivirito G., Pinna G., D'anna M., Klein L., Bucolo A., D'Anna R., Monaco C., La Ferrera G., Capobianco G., Olzai M. G., Angioni S., D'Alterio M. N., Serravalle P., Vicquery C., Scalchi S., Morando C., Meneghin M., Scapolan C., Maggino T., Guarinoni B., Cristina Napolitano G. M., De Vita M. G., Di Carlo C., Interlandi F., Bisceglia M., Michelangelo B., Arnulfo A., Finale E., Marozio L., Natali I., Grazia S. M., Staffler A., Tarani L., Coriale G., Messina M. P., D'Angelo A., Bonito M., Haass C., Capasso L., Raimondi F., De Bernardo G., Iacobelli P., Spadarella S., Enrica M., Rabuano R., Calzatini F., Bossi A., Aversa S., Prefumo F., Bellan C., Leone G., Ciammella M., Von-Wunster S., Liguori A., Ornaghi S., Fumagalli S., Sanguineti F., Gianola G., Cagnacci A., Amidani A., Sisto A., Di Marcello F., Santillo V., Di Bartolomeo C., Gerli S., Cagnoli G., Petrisano M., Pesce S., Di Lascio N., Falvino S., Appio P., Targiani V., Cavaliere A. F., Turrini I., Belli G., Beatrice G., Florio P., Innocenti E. D., Magi L., Civitelli F., Nappi L., Sorrentino F., Silvestris T., Indrio F., Laforgia N., Rizzo V., La Rocca M., Pradal U., Memo L., Diaz C., Riscica P., Bazzo S., La Maida N., Di Giorgi A., Pellegrini M., Ceccanti M., Caruso S., Ricci G., Neri I., Lana S., Minutillo A., Berretta P., Busardo F. P., and Pichini S.

Published
2023

2. Persistence of disease flares is associated to an inadequate colchicine dose in familial Mediterranean fever: a national multicentre longitudinal study

Author

Bustaffa, M, Mazza, F, Sutera, D, Carrabba, Md, Alessio, M, Cantarini, L, Obici, L, Rigante, D, Maggio, Mc, Insalaco A., Simonini G, Cattalini, M, Conti, G, Olivieri, An, Barone, P, Miniaci, A, Moressa, V, Magnolia, Mg, Breda, L, Montin, D, Spagnolo, A, Fabio, G, Orlando, F, Gaggiano, C, Mussinelli, R, Capozio, G, Celani, C, Marrani, E, Ricci, F, Calzatini, F, Lancieri, M, Ruperto, N, Gattorno, M, Gallizzi, R, Rigante D (ORCID:0000-0001-7032-7779), Conti G (ORCID:0000-0002-8566-9365), Bustaffa, M, Mazza, F, Sutera, D, Carrabba, Md, Alessio, M, Cantarini, L, Obici, L, Rigante, D, Maggio, Mc, Insalaco A., Simonini G, Cattalini, M, Conti, G, Olivieri, An, Barone, P, Miniaci, A, Moressa, V, Magnolia, Mg, Breda, L, Montin, D, Spagnolo, A, Fabio, G, Orlando, F, Gaggiano, C, Mussinelli, R, Capozio, G, Celani, C, Marrani, E, Ricci, F, Calzatini, F, Lancieri, M, Ruperto, N, Gattorno, M, Gallizzi, R, Rigante D (ORCID:0000-0001-7032-7779), and Conti G (ORCID:0000-0002-8566-9365)

Abstract

This study aimed at identifying the oersistence od disease in patients with FMF treated with colchicine. Almost 30% of FMF patients display a persistent disease activity not fulfilling the definition of colchicine resistance, but impacting on their quality of life. In most of these patients colchicine is under-dosed and maximum recommended dose is rarely used.

Published
2021

3. Persistence of disease flares is associated with an inadequate colchicine dose in familial Mediterranean fever: A national multicenter longitudinal study

Author

Angela Miniaci, Nicolino Ruperto, Maria Greca Magnolia, Alessandra Spagnolo, Giovanni Conti, Davide Montin, Maria Carrabba, Laura Obici, Giovanna Fabio, Edoardo Marrani, Giovanna Capozio, Marco Cattalini, Patrizia Barone, Maddalena Lancieri, Francesco Calzatini, Valentina Moressa, Maria Cristina Maggio, Gabriele Simonini, Camilla Celani, Luca Cantarini, Francesca Mazza, Diana Sutera, Roberta Mussinelli, Luciana Breda, Marta Bustaffa, Romina Gallizzi, Francesca Orlando, Maria Alessio, Antonella Insalaco, Alma Nunzia Olivieri, Donato Rigante, Carla Gaggiano, Francesca Ricci, Marco Gattorno, Bustaffa, M, Mazza, F, Sutera, D, Carrabba, Md, Alessio, M, Cantarini, L, Obici, L, Rigante, D, Maggio, Mc, Insalaco, A, Simonini, G, Cattalini, M, Conti, G, Olivieri, An, Barone, P, Miniaci, A, Moressa, V, Magnolia, Mg, Breda, L, Montin, D, Spagnolo, A, Fabio, G, Orlando, F, Gaggiano, C, Mussinelli, R, Capozio, G, Celani, C, Marrani, E, Ricci, F, Calzatini, F, Lancieri, M, Ruperto, N, Gattorno, M, Gallizzi, R, Bustaffa M., Mazza F., Sutera D., Carrabba M.D., Alessio M., Cantarini L., Obici L., Rigante D., Maggio M.C., Insalaco A., Simonini G., Cattalini M., Conti G., Olivieri A.N., Barone P., Miniaci A., Moressa V., Magnolia M.G., Breda L., Montin D., Spagnolo A., Fabio G., Orlando F., Gaggiano C., Mussinelli R., Capozio G., Celani C., Marrani E., Ricci F., Calzatini F., Lancieri M., Ruperto N., Gattorno M., and Gallizzi R.

Subjects
Longitudinal study, business.industry, Familial Mediterranean fever, Interleukin, Disease, Familial Mediterranea fever, medicine.disease, Symptom Flare Up, Colchicine, Humans, Interleukin 1 Receptor Antagonist Protein, Longitudinal Studies, Familial Mediterranean Fever, Persistence (computer science), chemistry.chemical_compound, Settore MED/38 - Pediatria Generale E Specialistica, chemistry, Colchicine, Humans, Interleukin 1 Receptor Antagonist Protein, Longitudinal Studies, Symptom Flare Up, Familial Mediterranean Fever, Immunology, COLCHICINE RESISTANCE, Immunology and Allergy, Medicine, business
Abstract

Familial Mediterranean fever (FMF) is characterized by self limited episodes of fever and polyserositis.1 MEFV gene en codes for a protein named Pyrin, which plays a pivotal role in the activation and secretion of IL-1.2 Daily colchicine is highly effective in preventing attacks in this disorder in a dose-related fashion.3 Many definitions of colchicine resistance are available in the literature. The European League Against Rheumatism (EULAR) guidelines defined resistance as one or more attacks per month in compliant patients who had been receiving the maxi mally tolerated dose for at least 6 months.4 A similar definition was confirmed by a recent consensus among experts.5 In the present national multicentric longitudinal study, we analyze the impact of colchicine treatment on disease activity and quality of life in real life in pediatric and adult patients with FMF.

Published
2021

4. Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy

Author

Maddalena Migliavacca, Paola Massariello, Roberto Miniero, Laura Lorioli, Laura Castagnaro, Francesca Tucci, Francesca Fumagalli, Francesco Calzatini, Miriam Casiraghi, Luca Santoleri, Claudia Fossati, Daniele Canarutto, Marcella Facchini, Maria Pia Cicalese, Fabio Ciceri, Alessandra Biffi, Matilde Zambelli, Sarah Marktel, Valeria Calbi, Stefano Zancan, Marta Claudia Frittoli, Paolo Silvani, Gigliola Antonioli, Giulia Consiglieri, Raffaella Milani, Silvia Darin, Francesca Ferrua, Salvatore Recupero, Maria Ester Bernardo, Salvatore Gattillo, Rossana Fiori, Alessandro Aiuti, Federica Barzaghi, Michele Manfredini, Tucci, F., Frittoli, M., Barzaghi, F., Calbi, V., Migliavacca, M., Ferrua, F., Fumagalli, F., Lorioli, L., Castagnaro, L., Facchini, M., Fossati, C., Zancan, S., Massariello, P., Manfredini, M., Consiglieri, G., Canarutto, D., Recupero, S., Calzatini, F., Casiraghi, M., Darin, S., Antonioli, G., Miniero, R., Fiori, R., Silvani, P., Zambelli, M., Marktel, S., Gattillo, S., Milani, R., Santoleri, L., Ciceri, F., Biffi, A., Cicalese, M. P., Bernardo, M. E., and Aiuti, A.

Subjects
Male, medicine.medical_specialty, Transplantation Conditioning, Genetic enhancement, Urology, CD34, Article, 03 medical and health sciences, 0302 clinical medicine, Bone Marrow, Medicine, Humans, Progenitor cell, Transplantation, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Genetic Therapy, medicine.disease, Metachromatic leukodystrophy, Haematopoiesis, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Bone marrow, Stem cell, business, Ex vivo, 030215 immunology
Abstract

Collection of an adequate amount of autologous haematopoietic stem progenitor cells (HSPC) is required for ex vivo manipulation and successful engraftment for certain inherited disorders. Fifty-seven paediatric patients (age 0.5–11.4 years) underwent a bone marrow harvest for the purpose of HSPC gene therapy (GT), including adenosine deaminase-severe combined immunodeficiency (ADA-SCID), Wiskott–Aldrich syndrome (WAS) and metachromatic leukodystrophy (MLD) patients. Total nucleated cells and the percentage and absolute counts of CD34+ cells were calculated at defined steps of the procedure (harvest, CD34+ cell purification, transduction with the gene transfer vector and infusion of the medicinal product). A minimum CD34+ cell dose for infusion was 2 × 106/kg, with an optimal target at 5–10 × 106/kg. Median volume of bone marrow harvested was 34.2 ml/kg (range 14.2–56.6). The number of CD34+ cells collected correlated inversely with weight and age in all patients and particularly in the MLD children group. All patients reached the minimum target dose for infusion: median dose of CD34+ cells/kg infused was 10.3 × 106/kg (3.7–25.9), with no difference among the three groups. Bone marrow harvest of volumes > 30 ml/kg in infants and children with ADA-SCID, WAS and MLD is well tolerated and allows obtaining an adequate dose of a medicinal product for HSPC-GT.

Published
2019

5. Persistence of disease flares is associated with an inadequate colchicine dose in familial Mediterranean fever: A national multicenter longitudinal study.

Author

Bustaffa M, Mazza F, Sutera D, Carrabba MD, Alessio M, Cantarini L, Obici L, Rigante D, Maggio MC, Insalaco A, Simonini G, Cattalini M, Conti G, Olivieri AN, Barone P, Miniaci A, Moressa V, Magnolia MG, Breda L, Montin D, Spagnolo A, Fabio G, Orlando F, Gaggiano C, Mussinelli R, Capozio G, Celani C, Marrani E, Ricci F, Calzatini F, Lancieri M, Ruperto N, Gattorno M, and Gallizzi R

Subjects
Colchicine, Humans, Interleukin 1 Receptor Antagonist Protein, Longitudinal Studies, Symptom Flare Up, Familial Mediterranean Fever drug therapy, Familial Mediterranean Fever epidemiology
Published
2021
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6. Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy.

Author

Tucci F, Frittoli M, Barzaghi F, Calbi V, Migliavacca M, Ferrua F, Fumagalli F, Lorioli L, Castagnaro L, Facchini M, Fossati C, Zancan S, Massariello P, Manfredini M, Consiglieri G, Canarutto D, Recupero S, Calzatini F, Casiraghi M, Darin S, Antonioli G, Miniero R, Fiori R, Silvani P, Zambelli M, Marktel S, Gattillo S, Milani R, Santoleri L, Ciceri F, Biffi A, Cicalese MP, Bernardo ME, and Aiuti A

Subjects
Female, Humans, Male, Bone Marrow metabolism, Genetic Therapy methods, Hematopoietic Stem Cell Transplantation methods, Transplantation Conditioning methods
Abstract

Collection of an adequate amount of autologous haematopoietic stem progenitor cells (HSPC) is required for ex vivo manipulation and successful engraftment for certain inherited disorders. Fifty-seven paediatric patients (age 0.5-11.4 years) underwent a bone marrow harvest for the purpose of HSPC gene therapy (GT), including adenosine deaminase-severe combined immunodeficiency (ADA-SCID), Wiskott-Aldrich syndrome (WAS) and metachromatic leukodystrophy (MLD) patients. Total nucleated cells and the percentage and absolute counts of CD34+ cells were calculated at defined steps of the procedure (harvest, CD34+ cell purification, transduction with the gene transfer vector and infusion of the medicinal product). A minimum CD34+ cell dose for infusion was 2 × 10 6 /kg, with an optimal target at 5-10 × 10 6 /kg. Median volume of bone marrow harvested was 34.2 ml/kg (range 14.2-56.6). The number of CD34+ cells collected correlated inversely with weight and age in all patients and particularly in the MLD children group. All patients reached the minimum target dose for infusion: median dose of CD34+ cells/kg infused was 10.3 × 10 6 /kg (3.7-25.9), with no difference among the three groups. Bone marrow harvest of volumes > 30 ml/kg in infants and children with ADA-SCID, WAS and MLD is well tolerated and allows obtaining an adequate dose of a medicinal product for HSPC-GT.

Published
2019
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7. Successful Treatment With Ledipasvir/Sofosbuvir in an Infant With Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency With HCV Allowed Gene Therapy with Strimvelis.

Author

Tucci F, Calbi V, Barzaghi F, Migliavacca M, Ferrua F, Bernardo ME, Canarutto D, Consiglieri G, Recupero S, Calzatini F, Gabaldo M, Lucano C, Casiraghi M, Darin S, Dionisio F, Marktel S, Cestone E, Finazzi R, Mieli-Vergani G, Boeri E, Appleby J, Abd Elaziz D, Ciceri F, Aiuti A, and Cicalese MP

Subjects
Agammaglobulinemia complications, Humans, Infant, Male, Severe Combined Immunodeficiency complications, Sofosbuvir, Uridine Monophosphate therapeutic use, Adenosine Deaminase deficiency, Agammaglobulinemia therapy, Antiviral Agents therapeutic use, Benzimidazoles therapeutic use, Fluorenes therapeutic use, Genetic Therapy, Hepatitis C drug therapy, Severe Combined Immunodeficiency therapy, Uridine Monophosphate analogs & derivatives
Published
2018
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