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The case report of a 55 year-old patient is described, with apparent good health up to 6 months before death who began to present chronic migraine which did not improve with treatment, personality disorders, confusion, cranial neuropathy, papilloedema and deep coma, without response to antifungal treatment. Keeping in mind the results of cerebrospinal liquid examination, a meningoencephalitis due to Cryptococcus was diagnosed; likewise the pathological study corroborated the existence of systemic cryptococcosis and AIDS. [ABSTRACT FROM AUTHOR]