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Aims To evaluate if rivaroxaban, an oral factor Xa (FXa) inhibitor, could modify the expression in vitro of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. Methods AAA sites with intraluminal mural thrombus were obtained from six patients undergoing elective AAA repair. In addition, control abdominal aortic samples were obtained from six organ donors. AAA sites were incubated in the presence and absence of 50 nmol l–1 rivaroxaban. Results AAA sites showing thrombus demonstrated higher content of FXa than control. Interleukin-6 levels released from AAA [Control: median: 23.45 (interquartile range: 16.17–37.15) vs. AAA: median: 153.07 (interquartile range: 100.80–210.69) pg ml–1 mg tissue–1, P < 0.05] and the expression levels of nitric oxide synthase 2 were significantly higher in AAA than in control. The protein expression level of NADPH oxidase subunits gp67-and gp91-phox, but did not gp47-phox, were also significantly higher in the AAA sites than in control. Addition of rivaroxaban to AAA sites explants significantly reduced the release of interleukin-6 [median: 51.61 (interquartile range: 30.87–74.03) pg ml–1 mg tissue–1, P < 0.05 with respect to AAA alone] and the content of nitric oxide synthase 2, gp67 and gp91-phox NADPH subunits. The content of matrix metallopeptidase 9 was significantly higher in the AAA sites as compared to control. Rivaroxaban also reduced matrix metallopeptidase 9 content in AAA sites to similar levels to control. Conclusions FXa inhibition by rivaroxaban exerted anti-inflammatory and antioxidative stress properties in human AAA sites, suggesting a role of FXa in these mechanisms associated with the pathogenesis of AAA., Depto. de Salud Pública y Materno - Infantil, Fac. de Medicina, TRUE, pub

The aim of this study is to investigate the possible differences generated by the stress of the different work shifts (morning, afternoon and night) to which a group of such importance such as the National Police Corps (CNP) is exposed daily and their temperament when facing stressful situations in their work life. Material and methods: The COPE test was used to address the stress parameters and the Personal Profile test for those of temperament, in a group of 14 police officers from the Autonomous Community of Madrid (Spain). Results: We observed significant differences in stress, when facing the problem, but not in temperament, highlighting key aspects such as alcohol and drug use in the night shift, extraversion, a predominance of blood temperament and more attention in the morning shift. . Conclusion: the majority coped with stress in a similar way, facing problems, with a high degree of acceptance of them, and controlling emotions. The afternoon shift is presented as the time of greatest drop in work performance, causing fatigue and exhaustion, symptoms that mark the drop in the level of security and increasing stress on national police officers. The majority of this group has suffered a temper crisis before their work, so it is advisable to promote research that generates coping strategies and can be adapted according to the moment that generates stress in their professional activity., El propósito de este estudio fue investigar las posibles diferencias generadas por el estrés de los diferentes turnos de trabajo (mañana, tarde y noche) a los que diariamente se expone un colectivo de tal importancia como es el Cuerpo Nacional de Policía (CNP) y la actitud emocional de estos, a la hora de enfrentarse a situaciones estresantes en su vida laboral. Materiales y métodos: se utilizó el test COPE para abordar los parámetros del estrés y el test de Perfil Personal para los de temperamento, en un grupo de 14 policías de la Comunidad Autónoma de Madrid (España). Resultados: observamos diferencias significativas en el estrés, a la hora de afrontar el problema, destacando aspectos clave como el consumo de alcohol y drogas en el turno de noche, extraversión, predominio de temperamento sanguíneo y más atención en el turno de mañana. Conclusión: la mayoría afrontaba el estrés de forma similar enfrentándose a los problemas, con un alto grado de aceptación de estos, y controlando las emociones. El turno de tarde se presentaba como el momento de peor rendimiento laboral, posiblemente provocado por el cansancio y el agotamiento, síntomas que marcan la bajada del nivel de seguridad y que pudiera ser causa de un aumento del estrés en los policías nacionales. La mayoría de este colectivo ha padecido crisis emocionales en su trabajo, por lo que es aconsejable fomentar investigaciones que generen estrategias de afrontamiento y puedan ser adaptadas según el momento generador del estrés en su actividad profesional.

The aim of this study was to determine how body composition parameters are modified in judo and wrestling. Both disciplines are organized by weight categories, this regularly leading to eating disorders and continuous dehydration in order to reach the needed competition weight. Also, this paper aims to understand whether there exist differences in this practice by gender and by sports discipline. A Biospace Inbody 230 system (CA, USA) was employed on a sample of 64 national elite judo and wrestling athletes from Spain and Portugal. Statistical analysis was performed using Kolmogorov-Smirnov and student t tests, which analyze mean differences. The findings and conclusions of the study showed a higher number of dehydrated athletes than those in optimal values of hydration during the pre-competitive period. This condition pushes athletes’ body to constant efforts and changes, possibly determining a detrimental effect on their short- and long-term performance, both in training and competitions., El propósito de este estudio fue conocer cómo se modifican los parámetros de composición corporal en deportes como judo y lucha, ambos deportes divididos por categorías de peso en los cuales, de manera habitual se producen desórdenes alimentarios y continuas deshidrataciones para la búsqueda del peso de competición. Igualmente se trató de conocer si existían diferencias entre hombres y mujeres en esta práctica y diferencias entre ambos deportes. Para ello, se utilizó el sistema Inbody Biospace 230 (CA,USA) a una muestra de élite nacional de judo y lucha del equipo español y portugués de 64 deportistas (n=64). El análisis estadístico se ejecutó mediante las pruebas: Kolmogorov-Smirnov y t de students para analizarlas diferencias de medias. Los resultados y conclusiones del estudio demostraron entre otros, que el número de atletas que se encontraban deshidratados en el momento pre-competitivo es mayor que los que están en valores óptimos de hidratación, sometiendo al organismo a constantes esfuerzos y cambios, pudiendo ser este un efecto perjudicial a corto y largo plazo en el rendimiento para el atleta, tanto en el entrenamientos como para la propia competición.

[EN] The training aimed to participate successfully in competitions of high performance is a constant internal struggle...