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2. Comparison of peripheral blood stem cell mobilization with filgrastim versus pegfilgrastim in lymphoma patients - single center experience.

Author

Lipan L, Colita A, Stefan L, Calugaroiu C, Serban C, Tomuleasa C, Pasca S, Colita A, and Tanase A

Subjects
Adult, Female, Humans, Male, Middle Aged, Prospective Studies, Filgrastim pharmacology, Filgrastim therapeutic use, Hematologic Agents pharmacology, Hematologic Agents therapeutic use, Hematopoietic Stem Cell Mobilization, Lymphoma drug therapy, Peripheral Blood Stem Cells drug effects, Polyethylene Glycols pharmacology, Polyethylene Glycols therapeutic use
Abstract

Purpose: The purpose of this study was to evaluate mobilization outcomes with biosimilar pegfilgrastim versus filgrastim in association with chemotherapy as a mobilization strategy for lymphoma patients., Methods: In the current study we included 32 lymphoma patients that received mobilization therapy and PBSC harvesting at the Bone Marrow Transplantation Department of Fundeni Clinical Institute, Bucharest, Romania between January and December 2019., Results: Pegfilgrastim had beneficial effect when compared to filgrastim in reducing grade IV neutropenia both in the univariate and multivariate logistic models. Additionally, similar efficacy, as mobilization rate, after both filgrastim and pegfilgrastim was observed and no differences were noted between the two groups considering the need for platelet or red blood cell support., Conclusion: The use of biosimilar pegfilgrastim is a viable alternative to filgrastim in PBSC mobilization for lymphoma patients.

Published
2021

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