Search

Your search keyword '"Caltavuturo, Leonardo"' showing total 14 results
Start Over Author "Caltavuturo, Leonardo"
14 results on '"Caltavuturo, Leonardo"'

12. Antimutagenicity of sodium selenite in Chinese hamster V79 cells exposed to azoxymethane, methylmethansulphonate and hydrogen peroxide

Author

Bronzetti, Giorgio, Cini, Marco, Caltavuturo, Leonardo, Fiorio, Roberto, and Croce, Clara Della

Abstract

In the last 10 years, there is an increasing interest in selenium (Se) because of its environmental, biological, and toxicological importance, and in particular, because of its antioxidant properties. However, inspite of extensive studies, the optimal concentration of Se to be used for its beneficial effects in not yet known. In addition, the mechanisms of Se antioxidant property require further study. We report on the effects of various mutagens/carcinogens such as azoxymethane, methylmethanesulphonate, and hydrogen peroxide on Chinese V79 hamster cells, in presence of sodium selenite in the concentration of 0.5μM. We found that Se reduced the genotoxic effect of these mutagens/carcinogens. We also investigated enzymatic activities of glutathione peroxidase, catalase, superoxide dismutase, and glutathione S-transferase, in order to understand the Se involvement in the detoxification of free radicals. Sodium selenite increased the activities of glutathione peroxidase and catalase.

Published
2003
Full Text
View/download PDF

13. Antimutagenesis studies of magnesium and calcium salts

Author

Cini, Marco, Ambrosini, Cinzia, Caltavuturo, Leonardo, Bronzetti, Giorgio, Aretini, Paolo, Fiorio, Roberto, Della Croce, Clara, and Panunzio, Michele

Subjects
ENZYME activation
Abstract

Magnesium is a microelement that is essential for biological functions and particularly for cellular metabolism. It has a central role inprotein, lipid, carbohydrate, and nucleic acid synthesis, and it is important for muscular physiology and nerve excitability. Magnesium has an important role in the stability of biological membranes, it controls immune phenomena, and it activates over 300 enzymes. However, the mechanism of action of magnesium salts has not been well investigated and, in particular, its antimutagenesis properties and its effects in the detoxification of free radicals need further study. We investigated the effect of magnesium chloride, sulphate, carbonate, and oxide on the yeast Saccharomyces cereuisiae D7 strain, to evaluate their ability to protect against genotoxic damage. We found that; magnesium salts induced antimutagenic effects in the cells harvested in the logarithmic phase by decreasing the induction of hydrogen peroxide. This, however, did not occur in the stationary phase. We also studied calcium salts of the type corresponding to those of magnesium and their protective role against the oxidative damage of free radicals and enzymatic activities, such as catalase, glutathione peroxidase, and superoxide dismutase, which are involved in antioxidative defenses. [ABSTRACT FROM AUTHOR]

Published
2000

14. Citrus bergamia powder: Antioxidant, antimicrobial and anti-inflammatory properties

Author

Diana Di Gioia, Stefania Frassinetti, Laura Pucci, Vincenzo Longo, Giovanni Dinelli, Morena Gabriele, Leonardo Caltavuturo, Lidia Montero, Gabriele, Morena, Frassinetti, Stefania, Caltavuturo, Leonardo, Montero, Lidia, Dinelli, Giovanni, Longo, Vincenzo, Di Gioia, Diana, Pucci, Laura, and Consiglio Nazionale delle Ricerche

Subjects
0301 basic medicine, HMEC-1, Antioxidant, LPS, medicine.drug_class, medicine.medical_treatment, Endothelial activation and dysfunction, Medicine (miscellaneous), medicine.disease_cause, Probiotic, Bergamot fruit, Anti-inflammatory, 03 medical and health sciences, Flavonols, medicine, TX341-641, Food science, MIC, chemistry.chemical_classification, 030109 nutrition & dietetics, Nutrition and Dietetics, Nutrition. Foods and food supply, Probiotics, food and beverages, Pathogenic bacteria, Antimicrobial, Ascorbic acid, 030104 developmental biology, Biochemistry, chemistry, Polyphenol, Citrus bergamia, Food Science
Abstract

Bergamot whole-fruit powder was analyzed for total polyphenols, flavonoids, flavonols and ascorbic acid content and tested for in vitro and ex vivo antioxidant activity. The flavonoids profile was further characterized via HPLC-DAD-MS/MS and the most abundant flavonoids were quantified. The antimicrobial activity against potentially pathogenic bacteria and the effect on beneficial gut bacteria were determined. Lastly, we evaluated the effects of bergamot extract on endothelial alterations in LPS-stimulated human microvascular endothelial cells (HMEC-1). Our data demonstrated that bergamot powder possesses in vitro and ex vivo antioxidant activity, shows a selective inhibition against pathogenic strains and growth stimulation effects on some beneficial gut bacteria. Moreover, it protects HMEC-1 from LPS-induced activation and dysfunction and reduces the resulting endoplasmic reticulum stress. The relationship between isolated flavonoids and the protective effects are discussed. In conclusion, bergamot whole-fruit powder possesses beneficial health effects that makes it a potentially useful material for the nutraceutical industry., This study was supported by CNR (Consiglio Nazionale delle Ricerche, Italy) and by Farmanatura, Italy.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results