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1. Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial

Author

Luvira, Viravarn, Schilling, William H. K., Jittamala, Podjanee, Watson, James A., Boyd, Simon, Siripoon, Tanaya, Ngamprasertchai, Thundon, Almeida, Pedro J., Ekkapongpisit, Maneerat, Cruz, Cintia, Callery, James J., Singh, Shivani, Tuntipaiboontana, Runch, Kruabkontho, Varaporn, Ngernseng, Thatsanun, Tubprasert, Jaruwan, Abdad, Mohammad Yazid, Keayarsa, Srisuda, Madmanee, Wanassanan, Aguiar, Renato S., Santos, Franciele M., Hanboonkunupakarn, Pongtorn, Hanboonkunupakarn, Borimas, Poovorawan, Kittiyod, Imwong, Mallika, Taylor, Walter R. J., Chotivanich, Vasin, Chotivanich, Kesinee, Pukrittayakamee, Sasithon, Dondorp, Arjen M., Day, Nicholas P. J., Teixeira, Mauro M., Piyaphanee, Watcharapong, Phumratanaprapin, Weerapong, and White, Nicholas J.

Published
2024
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2. Expanding the roles of community health workers to sustain programmes during malaria elimination: a meeting report on operational research in Southeast Asia

Author

Dysoley, Lek, Callery, James J., Bunreth, Voeurng, Vanna, Moul, Davoeung, Chan, Sovann, Yok, You, Sles, Ol, Sam, Tripura, Rupam, Chew, Rusheng, Chandna, Arjun, Christiansen-Jucht, Céline, Hughes, Jayme, Sokomar, Nguon, Sophornarann, Top, Rideout, Jeanne, Veyvath, Tat, Sarith, Oum, Puthy, Thaung, Sothearoth, Hay, An, Sen Sam, Zaman, Sazid Ibna, von Seidlein, Lorenz, Vanthy, Lim, Sodavuth, Preap, Vannak, Chrun, Dondorp, Arjen M., Lubell, Yoel, Maude, Richard J., Peto, Thomas J., and Adhikari, Bipin

Published
2024
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3. Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

Author

Schilling, William H. K., Mukaka, Mavuto, Callery, James J., Llewelyn, Martin J., Cruz, Cintia V., Dhorda, Mehul, Ngernseng, Thatsanun, Waithira, Naomi, Ekkapongpisit, Maneerat, Watson, James A., Chandna, Arjun, Nelwan, Erni J., Hamers, Raph L., Etyang, Anthony, Beg, Mohammad Asim, Sow, Samba, Yavo, William, Allabi, Aurel Constant, Basnyat, Buddha, Sharma, Sanjib Kumar, Amofa-Sekyi, Modupe, Yonga, Paul, Adler, Amanda, Yuentrakul, Prayoon, Cope, Tanya, Thaipadungpanit, Janjira, Rienpradub, Panuvit, Imwong, Mallika, Abdad, Mohammad Yazid, Blacksell, Stuart D., Tarning, Joel, Goudjo, Frejus Faustin, Dossou, Ange D., Konaté-Touré, Abibatou, Assi, Serge-Brice, Ouffoué, Kra, Nasronudin, Nasronudin, Rachman, Brian Eka, Romadhon, Pradana Zaky, Dewanto, Didi Darmahadi, Heryana, Made Oka, Novi, Theresia, Pasaribu, Ayodhia Pitaloka, Mutiara, Mutiara, Nasution, Miranda Putri Rahayu, Khairunnisa, Khairunnisa, Dalimunthe, Fauzan Azima, Airlangga, Eka, Fahrezzy, Akmal, Subronto, Yanri, Ananda, Nur Rahmi, Rahardjani, Mutia, Rimainar, Atika, Lucinde, Ruth Khadembu, Timbwa, Molline, Onyango, Otieno Edwin, Agutu, Clara, Akech, Samuel, Hamaluba, Mainga, Kipyego, Jairus, Ngachi, Obadiah, Haidara, Fadima Cheick, Traoré, Oumar Y., Diarra, François, Khanal, Basudha, Dahal, Piyush, Shrestha, Suchita, Rijal, Samita, Kabore, Youssouf, Adehossi, Eric, Guindo, Ousmane, Qamar, Farah Naz, Kazi, Abdul Momin, Woodrow, Charles J., Laird, Steven, Cheeba, Maina, Ayles, Helen, Cheah, Phaik Yeong, Taylor, Walter R. J., Batty, Elizabeth M., Chotivanich, Kesinee, Pukrittayakamee, Sasithon, Phumratanaprapin, Weerapong, von Seidlein, Lorenz, Dondorp, Arjen, Day, Nicholas P. J., and White, Nicholas J.

Subjects
Hydroxychloroquine -- Testing, Chloroquine -- Testing, Biological sciences
Abstract

Background Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show benefit of HCQ against COVID-19 and, although meta-analysis did suggest clinical benefit, guidelines recommend against its use. Methods and findings Healthy adult participants from the healthcare setting, and later from the community, were enrolled in 26 centres in 11 countries to a double-blind, placebo-controlled, randomised trial of COVID-19 chemoprevention. HCQ was evaluated in Europe and Africa, and chloroquine (CQ) was evaluated in Asia, (both base equivalent of 155 mg once daily). The primary endpoint was symptomatic COVID-19, confirmed by PCR or seroconversion during the 3-month follow-up period. The secondary and tertiary endpoints were: asymptomatic laboratory-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection; severity of COVID-19 symptoms; all-cause PCR-confirmed symptomatic acute respiratory illness (including SARS-CoV-2 infection); participant reported number of workdays lost; genetic and baseline biochemical markers associated with symptomatic COVID-19, respiratory illness and disease severity (not reported here); and health economic analyses of HCQ and CQ prophylaxis on costs and quality of life measures (not reported here). The primary and safety analyses were conducted in the intention-to-treat (ITT) population. Recruitment of 40,000 (20,000 HCQ arm, 20,000 CQ arm) participants was planned but was not possible because of protracted delays resulting from controversies over efficacy and adverse events with HCQ use, vaccine rollout in some countries, and other factors. Between 29 April 2020 and 10 March 2022, 4,652 participants (46% females) were enrolled (HCQ/CQ n = 2,320; placebo n = 2,332). The median (IQR) age was 29 (23 to 39) years. SARS-CoV-2 infections (symptomatic and asymptomatic) occurred in 1,071 (23%) participants. For the primary endpoint the incidence of symptomatic COVID-19 was 240/2,320 in the HCQ/CQ versus 284/2,332 in the placebo arms (risk ratio (RR) 0.85 [95% confidence interval, 0.72 to 1.00; p = 0.05]). For the secondary and tertiary outcomes asymptomatic SARS-CoV-2 infections occurred in 11.5% of HCQ/CQ recipients and 12.0% of placebo recipients: RR: 0.96 (95% CI, 0.82 to 1.12; p = 0.6). There were no differences in the severity of symptoms between the groups and no severe illnesses. HCQ/CQ chemoprevention was associated with fewer PCR-confirmed all-cause respiratory infections (predominantly SARS-CoV-2): RR 0.61 (95% CI, 0.42 to 0.88; p = 0.009) and fewer days lost to work because of illness: 104 days per 1,000 participants over 90 days (95% CI, 12 to 199 days; p < 0.001). The prespecified meta-analysis of all published pre-exposure RCTs indicates that HCQ/CQ prophylaxis provided a moderate protective benefit against symptomatic COVID-19: RR 0.80 (95% CI, 0.71 to 0.91). Both drugs were well tolerated with no drug-related serious adverse events (SAEs). Study limitations include the smaller than planned study size, the relatively low number of PCR-confirmed infections, and the lower comparative accuracy of serology endpoints (in particular, the adapted dried blood spot method) compared to the PCR endpoint. The COPCOV trial was registered with ClinicalTrials.gov; number NCT04303507. Interpretation In this large placebo-controlled, double-blind randomised trial, HCQ and CQ were safe and well tolerated in COVID-19 chemoprevention, and there was evidence of moderate protective benefit in a meta-analysis including this trial and similar RCTs. Trial registration ClinicalTrials.gov NCT04303507; ISRCTN Registry ISRCTN10207947., Author(s): William H. K. Schilling 1,2,*, Mavuto Mukaka 1,2, James J. Callery 1,2, Martin J. Llewelyn 3,4, Cintia V. Cruz 1,2, Mehul Dhorda 1,2, Thatsanun Ngernseng 1, Naomi Waithira 1,2, [...]

Published
2024
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4. Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial

Author

White, Nicholas J, Schilling, William HK, Phumratanaprapin, Weerapong, Luvira, Viravarn, Callery, James J, Day, Nicholas PJ, Pukrittayakamee, Sasithon, Boyd, Simon, Cruz, Cintia, Dondorp, Arjen M, Taylor, Walter RJ, Watson, James A, Piyaphanee, Watcharapong, Poovorawan, Kittiyod, Ngamprasertchai, Thundon, Siripoon, Tanaya, Hanboonkunupakarn, Borimas, Chotivanich, Kesinee, Jittamala, Podjanee, Imwong, Mallika, Thaipadungpanit, Janjira, Ekkapongpisit, Maneerat, Kruabkontho, Varaporn, Ngernseng, Thatsanun, Tubprasert, Jaruwan, Abdad, Mohammad Yazid, Batty, Elizabeth M, Singh, Shivani, Chotivanich, Vasin, Ruksakul, Wiroj, Sangketchon, Chunlanee, Hanboonkunupakarn, Pongtorn, Sookprome, Sakol, Teixeira, Mauro, Almeida, Pedro J, Aguiar, Renato S, Santos, Franciele, Ashley, Elizabeth, Vongsouvath, Manivanh, Phommasone, Koukeo, Dubot-Pérès, Audrey, Vidhamaly, Sisouphanh, Chingsanoon, Ammala, Bisayher, Sixiong, Chommanam, Danoy, Evans, Terry John, Vidhamaly, Vayouly, Boutthasavong, Latsaniphone, Mayxay, Mayfong, Potaporn, Manus, Srisubat, Attasit, Loharjun, Bootsakorn, Schilling, William H K, Saroj, Manisaree, Tanglakmankhong, Nuttakan, Madmanee, Wanassanan, Kouhathong, Jindarat, Suwannasin, Kanokon, Pagornrat, Watcharee, Piaraksa, Nattaporn, Taylor, Walter R J, Day, Nicholas P J, and Teixeira, Mauro M

Published
2024
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6. Antimalarial chemoprophylaxis for forest goers in southeast Asia: an open-label, individually randomised controlled trial

Author

Tripura, Rupam, von Seidlein, Lorenz, Sovannaroth, Siv, Peto, Thomas J, Callery, James J, Sokha, Meas, Ean, Mom, Heng, Chhouen, Conradis-Jansen, Franca, Madmanee, Wanassanan, Peerawaranun, Pimnara, Waithira, Naomi, Khonputsa, Panarasri, Jongdeepaisal, Monnaphat, Pongsoipetch, Kulchada, Chotthanawathit, Paphapisa, Soviet, Ung, Pell, Christopher, Duanguppama, Jureeporn, Rekol, Huy, Tarning, Joel, Imwong, Mallika, Mukaka, Mavuto, White, Nicholas J, Dondorp, Arjen M, and Maude, Richard J

Published
2023
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7. Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial

Author

Peto, Thomas J, Tripura, Rupam, Callery, James J, Lek, Dysoley, Nghia, Ho Dang Trung, Nguon, Chea, Thuong, Nguyen Thi Huyen, van der Pluijm, Rob W, Dung, Nguyen Thi Phuong, Sokha, Meas, Van Luong, Vo, Long, Le Thanh, Sovann, Yok, Duanguppama, Jureeporn, Waithira, Naomi, Hoglund, Richard M, Chotsiri, Palang, Chau, Nguyen Hoang, Ruecker, Andrea, Amaratunga, Chanaki, Dhorda, Mehul, Miotto, Olivo, Maude, Richard J, Rekol, Huy, Chotivanich, Kesinee, Tarning, Joel, von Seidlein, Lorenz, Imwong, Mallika, Mukaka, Mavuto, Day, Nicholas P J, Hien, Tran Tinh, White, Nicholas J, and Dondorp, Arjen M

Published
2022
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8. Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Published
2022
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10. Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)

Author

Jittamala, Podjanee, primary, Boyd, Simon, additional, Schilling, William Henry Keith, additional, Watson, James Andrew, additional, Ngamprasertchai, Thundon, additional, Siripoon, Tanaya, additional, Luvira, Viravarn, additional, Batty, Elizabeth M, additional, Wongnak, Phrutsamon, additional, Esper, Lisia M, additional, Almeida, Pedro J, additional, Cruz, Cintia, additional, Ascencao, Fernando R, additional, Aguiar, Renato S, additional, Ghanchi, Najia K, additional, Callery, James J, additional, Singh, Shivani, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Madmanee, Wanassanan, additional, Suwannasin, Kanokon, additional, Promsongsil, Amornrat, additional, Hanboonkunupakarn, Borimas, additional, Poovorawan, Kittiyod, additional, Potaporn, Manus, additional, Srisubat, Attasit, additional, Loharjun, Bootsakorn, additional, Taylor, Walter RJ, additional, Qamar, Farah N, additional, Kazi, Abdul Momin, additional, Beg, M Asim, additional, Chommanam, Danoy, additional, Vidhamaly, Sisouphanh, additional, Chotivanich, Kesinee, additional, Imwong, Mallika, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2024
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13. Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages

Author

Betrian, Mipharny, primary, Umans, Dafne, additional, Vanna, Moul, additional, Ol, Sam, additional, Adhikari, Bipin, additional, Davoeung, Chan, additional, Callery, James J., additional, Sovann, Yok, additional, Peto, Thomas J., additional, Maude, Richard J., additional, van der Pluijm, Rob W., additional, Bunreth, Voeunrung, additional, Grobusch, Martin P., additional, van Vugt, Michèle, additional, Lubell, Yoel, additional, von Seidlein, Lorenz, additional, Dondorp, Arjen M., additional, Sovannaroth, Siv, additional, Lek, Dysoley, additional, and Tripura, Rupam, additional

Published
2023
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14. Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial

Author

Schilling, William H K, primary, Jittamala, Podjanee, additional, Watson, James A, additional, Boyd, Simon, additional, Luvira, Viravarn, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Batty, Elizabeth M, additional, Cruz, Cintia, additional, Callery, James J, additional, Singh, Shivani, additional, Saroj, Manisaree, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tanglakmankhong, Nuttakan, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Madmanee, Wanassanan, additional, Kouhathong, Jindarat, additional, Suwannasin, Kanokon, additional, Pagornrat, Watcharee, additional, Piaraksa, Nattaporn, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Poovorawan, Kittiyod, additional, Potaporn, Manus, additional, Srisubat, Attasit, additional, Loharjun, Bootsakorn, additional, Taylor, Walter R J, additional, Chotivanich, Vasin, additional, Chotivanich, Kesinee, additional, Imwong, Mallika, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas P J, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, White, Nicholas J, additional, Schilling, William HK, additional, Day, Nicholas PJ, additional, Taylor, Walter RJ, additional, Thaipadungpanit, Janjira, additional, Ekkapongpisit, Maneerat, additional, Ruksakul, Wiroj, additional, Sangketchon, Chunlanee, additional, Sookprome, Sakol, additional, Teixeira, Mauro, additional, Almeida, Pedro J, additional, Aguiar, Renato S, additional, Santos, Franciele, additional, Ashley, Elizabeth, additional, Vongsouvath, Manivanh, additional, Phommasone, Koukeo, additional, Dubot-Pérès, Audrey, additional, Vidhamaly, Sisouphanh, additional, Chingsanoon, Ammala, additional, Bisayher, Sixiong, additional, Chommanam, Danoy, additional, Evans, Terry John, additional, Vidhamaly, Vayouly, additional, Boutthasavong, Latsaniphone, additional, and Mayxay, Mayfong, additional

Published
2023
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15. Artemisinin-resistant malaria in Africa demands urgent action.

Author

Dhorda, Mehul, Akira Kaneko, Ryuichi Komatsu, K. C., Achyut, Mshamu, Salum, Gesase, Samwel, Kapologwe, Ntuli, Assefa, Ashenafi, Opigo, Jimmy, Adoke, Yeka, Ebong, Chris, Karema, Corine, Uwimana, Aline, Mangara, Jean-Louis Ndikumana, Amaratunga, Chanaki, Peto, Thomas J., Tripura, Rupam, Callery, James J., Adhikari, Bipin, and Mukaka, Mavuto

Published
2024
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16. Clinical antiviral efficacy of remdesivir in COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV)

Author

Jittamala, Podjanee, primary, Schilling, William H K, additional, Watson, James A, additional, Luvira, Viravarn, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Almeida, Pedro J, additional, Ekkapongpisit, Maneerat, additional, Cruz, Cintia, additional, Callery, James J, additional, Boyd, Simon, additional, Anunsittichai, Orawan, additional, Hongsuwan, Maliwan, additional, Singhaboot, Yutatirat, additional, Pagornrat, Watcharee, additional, Tuntipaiboontana, Runch, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Keayarsa, Srisuda, additional, Madmanee, Wanassanan, additional, Aguiar, Renato S, additional, Santos, Franciele M, additional, Batty, Elizabeth M, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Sookprome, Sakol, additional, Poovorawan, Kittiyod, additional, Imwong, Mallika, additional, Taylor, Walter R J, additional, Chotivanich, Vasin, additional, Sangketchon, Chunlanee, additional, Ruksakul, Wiroj, additional, Chotivanich, Kesinee, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas P J, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2023
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17. The feasibility of novel point-of-care diagnostics for febrile illnesses at health centres in Southeast Asia: a mixed-methods study

Author

Adella, Fidelis Jacklyn, primary, Vanna, Moul, additional, Adhikari, Bipin, additional, Ol, Sam, additional, Tripura, Rupam, additional, Davoeung, Chan, additional, Callery, James J, additional, Sovann, Yok, additional, Chandna, Arjun, additional, Bunreth, Voeunrung, additional, Asnong, Carina, additional, von Seidlein, Lorenz, additional, Dondorp, Arjen M, additional, Maude, Richard J, additional, Lubell, Yoel, additional, Wills, Bridget, additional, Lek, Dysoley, additional, and Peto, Thomas J, additional

Published
2023
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18. Community engagement among forest goers in a malaria prophylaxis trial: implementation challenges and implications

Author

Conradis-Jansen, Franca, primary, Tripura, Rupam, additional, Peto, Thomas J., additional, Callery, James J., additional, Adhikari, Bipin, additional, Ean, Mom, additional, Jongdeepaisal, Monnaphat, additional, Pell, Christopher, additional, Khonputsa, Panarasri, additional, Murgia, Riccardo, additional, Sovannaroth, Siv, additional, Müller, Olaf, additional, Cheah, Phaik Yeong, additional, Dondorp, Arjen M., additional, von Seidlein, Lorenz, additional, and Maude, Richard J., additional

Published
2023
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19. Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report

Author

Lek, Dysoley, Callery, James J., Nguon, Chea, Debackere, Mark, Sovannaroth, Siv, Tripura, Rupam, Wojnarski, Marius, Piola, Patrice, Khean, Soy Ty, Manion, Kylie, Nguon, Sokomar, Kunkel, Amber, Vernaeve, Lieven, Peto, Thomas J., Dantzer, Emily, Davoeung, Chan, Etienne, William, Dondorp, Arjen M., Tuseo, Luciano, von Seidlein, Lorenz, and Guintran, Jean-Olivier

Published
2020
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20. Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open- label, randomised, controlled adaptive platform trial

Author

Luvira, Viravarn, primary, Schilling, William HK, additional, Jittamala, Podjanee, additional, Watson, James A, additional, Boyd, Simon, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Almeida, Pedro J, additional, Ekkapongpisit, Maneerat, additional, Cruz, Cintia, additional, Callery, James J, additional, Singh, Shivani, additional, Tuntipaiboontana, Runch, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Keayarsa, Srisuda, additional, Madmanee, Wanassanan, additional, Aguiar, Renato S, additional, Santos, Franciele M, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Poovorawan, Kittiyod, additional, Imwong, Mallika, additional, Taylor, Walter RJ, additional, Chotivanich, Vasin, additional, Chotivanich, Kesinee, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2023
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21. Glucose-6-Phosphate Dehydrogenase (G6PD) Measurement Using Biosensors by Community-Based Village Malaria Workers and Hospital Laboratory Staff in Cambodia: A Quantitative Study

Author

Adhikari, Bipin, primary, Tripura, Rupam, additional, Dysoley, Lek, additional, Peto, Thomas J., additional, Callery, James J., additional, Heng, Chhoeun, additional, Vanda, Thy, additional, Simvieng, Ou, additional, Cassidy-Seyoum, Sarah, additional, Thriemer, Kamala, additional, Dondorp, Arjen M., additional, Ley, Benedikt, additional, and Seidlein, Lorenz von, additional

Published
2023
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23. Clinical Antiviral Efficacy of Remdesivir in Coronavirus Disease 2019: An Open-Label, Randomized Controlled Adaptive Platform Trial (PLATCOV).

Author

Jittamala, Podjanee, Schilling, William H K, Watson, James A, Luvira, Viravarn, Siripoon, Tanaya, Ngamprasertchai, Thundon, Almeida, Pedro J, Ekkapongpisit, Maneerat, Cruz, Cintia, Callery, James J, Boyd, Simon, Anunsittichai, Orawan, Hongsuwan, Maliwan, Singhaboot, Yutatirat, Pagornrat, Watcharee, Tuntipaiboontana, Runch, Kruabkontho, Varaporn, Ngernseng, Thatsanun, Tubprasert, Jaruwan, and Abdad, Mohammad Yazid

Subjects
SARS-CoV-2, COVID-19, REMDESIVIR, CORONAVIRUS diseases
Abstract

Background Uncertainty over the therapeutic benefit of parenteral remdesivir in coronavirus disease 2019 (COVID-19) has resulted in varying treatment guidelines. Methods In a multicenter open-label, controlled, adaptive, pharmacometric platform trial, low-risk adult patients with early symptomatic COVID-19 were randomized to 1 of 8 treatment arms including intravenous remdesivir (200 mg followed by 100 mg daily for 5 days) or no study drug. The primary outcome was the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance (estimated under a linear model fit to the daily log10 viral densities, days 0–7) in standardized duplicate oropharyngeal swab eluates, in a modified intention-to-treat population. This ongoing adaptive trial is registered at ClinicalTrials.gov (NCT05041907). Results The 2 study arms enrolled 131 patients (remdesivir n = 67, no study drug n = 64) and estimated viral clearance rates from a median of 18 swab samples per patient (a total of 2356 quantitative polymerase chain reactions). Under the linear model, compared with the contemporaneous control arm (no study drug), remdesivir accelerated mean estimated viral clearance by 42% (95% credible interval, 18%–73%). Conclusions Parenteral remdesivir accelerates viral clearance in early symptomatic COVID-19. Pharmacometric assessment of therapeutics using the method described can determine in vivo clinical antiviral efficacy rapidly and efficiently. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Author response: Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

Author

Schilling, William HK, primary, Jittamala, Podjanee, primary, Watson, James A, additional, Ekkapongpisit, Maneerat, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Luvira, Viravarn, additional, Pongwilai, Sasithorn, additional, Cruz, Cintia, additional, Callery, James J, additional, Boyd, Simon, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Piaraksa, Nattaporn, additional, Suwannasin, Kanokon, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Sookprome, Sakol, additional, Poovorawan, Kittiyod, additional, Thaipadungpanit, Janjira, additional, Blacksell, Stuart, additional, Imwong, Mallika, additional, Tarning, Joel, additional, Taylor, Walter RJ, additional, Chotivanich, Vasin, additional, Sangketchon, Chunlanee, additional, Ruksakul, Wiroj, additional, Chotivanich, Kesinee, additional, Teixeira, Mauro Martins, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2023
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25. Effectiveness of community engagement among forest goers in a malaria prophylaxis trial: Implementation challenges and implications

Author

Conradis-Jansen, Franca, primary, Tripura, Rupam, additional, Peto, Thomas J, additional, Callery, James J, additional, Adhikari, Bipin, additional, Eam, Mom, additional, Jongdeepaisal, Monnaphat, additional, Pell, Christopher, additional, Khonputsa, Panarasri, additional, Murgia, Riccardo, additional, Sovannaroth, Siv, additional, Müller, Olaf, additional, Cheah, Phaik Yeong, additional, Dondorp, Arjen M, additional, von Seidlein, Lorenz, additional, and Maude, Richard James, additional

Published
2023
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26. Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries

Author

Srisutham, Suttipat, primary, Madmanee, Wanassanan, additional, Kouhathong, Jindarat, additional, Sutawong, Kreepol, additional, Tripura, Rupam, additional, Peto, Thomas J., additional, van der Pluijm, Rob W., additional, Callery, James J., additional, Dysoley, Lek, additional, Mayxay, Mayfong, additional, Newton, Paul N., additional, Pongvongsa, Tiengkham, additional, Hongvanthong, Bouasy, additional, Day, Nicholas P. J., additional, White, Nicholas J., additional, Dondorp, Arjen M., additional, and Imwong, Mallika, additional

Published
2022
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27. Good participatory practice for coronavirus disease 2019 (COVID-19) research: the case of a COVID-19 prevention study

Author

Perrone, Carlo, primary, Schilling, William, additional, Callery, James J., additional, Ashley, Elizabeth A., additional, Chambers, Mary, additional, Chase, Hannah, additional, Dahal, Piyush, additional, Kanthawang, Nipaphan, additional, Nedsuwan, Supalert, additional, Hanboonkunupakarn, Borimas, additional, Intralawan, Daranee, additional, Karkey, Abhilasha, additional, Mayxay, Mayfong, additional, Souvong, Vimalay, additional, Tran Minh, Hien, additional, Udas Shakya, Summita, additional, Sharma, Sanjib Kumar, additional, Uranw, Surendra, additional, Vannachione, Souphaphone, additional, Woodrow, Charles, additional, White, Nicholas J., additional, and Cheah, Phaik Yeong, additional

Published
2022
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28. Clinical antiviral efficacy of remdesivir and casirivimab/imdevimab against the SARS-CoV-2 Delta and Omicron variants

Author

Jittamala, Podjanee, primary, Schilling, William HK, additional, Watson, James A, additional, Luvira, Viravarn, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Almeida, Pedro J, additional, Ekkapongpisit, Maneerat, additional, Cruz, Cintia, additional, Callery, James J, additional, Boyd, Simon, additional, Anunsittichai, Orawan, additional, Hongsuwan, Maliwan, additional, Singhaboot, Yutatirat, additional, Pagornrat, Watcharee, additional, Tuntipaiboontana, Runch, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Keayarsa, Srisuda, additional, Madmanee, Wanassanan, additional, Aguiar, Renato S, additional, Santos, Franciele M, additional, Batty, Elizabeth M, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Sookprome, Sakol, additional, Poovorawan, Kittiyod, additional, Imwong, Mallika, additional, Taylor, Walter RJ, additional, Chotivanich, Vasin, additional, Sangketchon, Chunlanee, additional, Ruksakul, Wiroj, additional, Chotivanich, Kesinee, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2022
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29. Pharmacometric assessment of the in vivo antiviral activity of ivermectin in early symptomatic COVID-19

Author

Schilling, William HK, primary, Jittamala, Podjanee, additional, Watson, James A, additional, Ekkapongpisit, Maneerat, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Luvira, Viravarn, additional, Pongwilai, Sasithon, additional, Cruz, Cintia, additional, Callery, James J, additional, Boyd, Simon, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Piaraksa, Nattaporn, additional, Suwannasin, Kanokon, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Sookprome, Sakol, additional, Poovorawan, Kittiyod, additional, Thaipadungpanit, Janjira, additional, Blacksell, Stuart, additional, Imwong, Mallika, additional, Tarning, Joel, additional, Taylor, Walter RJ, additional, Chotivanich, Vasin, additional, Sangketchon, Chunlanee, additional, Ruksakul, Wiroj, additional, Chotivanich, Kesinee, additional, Teixeira, Mauro M, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2022
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31. Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV).

Author

Schilling, William H. K., Podjanee Jittamala, Watson, James A., Maneerat Ekkapongpisit, Tanaya Siripoon, Thundon Ngamprasertchai, Viravarn Luvira, Sasithorn Pongwilai, Cintia Cruz, Callery, James J., Boyd, Simon, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Abdad, Mohammad Yazid, Nattaporn Piaraksa, Kanokon Suwannasin, Pongtorn Hanboonkunupakarn, Borimas Hanboonkunupakarn, and Sakol Sookprome

Published
2023
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32. Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project

Author

Chandna, Arjun, primary, Chew, Rusheng, additional, Shwe Nwe Htun, Nan, additional, Peto, Thomas J., additional, Zhang, Meiwen, additional, Liverani, Marco, additional, Brummaier, Tobias, additional, Phommasone, Koukeo, additional, Perrone, Carlo, additional, Pyae Phyo, Aung, additional, Sattabongkot, Jetsumon, additional, Roobsoong, Wanlapa, additional, Nguitragool, Wang, additional, Sen, Aninda, additional, Ibna Zaman, Sazid, additional, Sandar Zaw, Aye, additional, Batty, Elizabeth, additional, Waithira, Naomi, additional, Abdad, Mohammad Yazid, additional, Blacksell, Stuart D., additional, Bodhidatta, Ladaporn, additional, Callery, James J., additional, Fagnark, Watcharintorn, additional, Huangsuranun, Witchayoot, additional, Islam, Shayla, additional, Lertcharoenchoke, Sanchai, additional, Lohavittayavikant, Salisa, additional, Mukaka, Mavuto, additional, Moul, Vanna, additional, Kumer Neogi, Amit, additional, Nedsuwan, Supalert, additional, Pongvongsa, Tiengkham, additional, Ponsap, Pimsiri, additional, Richard-Greenblatt, Melissa, additional, Schilling, William H.K., additional, Thaipadungpanit, Janjira, additional, Tripura, Rupam, additional, Dondorp, Arjen M., additional, Mayxay, Mayfong, additional, White, Nicholas J., additional, Nosten, François, additional, Smithuis, Frank, additional, Ashley, Elizabeth A., additional, Maude, Richard J., additional, Day, Nicholas P.J., additional, and Lubell, Yoel, additional

Published
2022
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33. Additional file 2 of Glucose 6 Phosphate Dehydrogenase (G6PD) quantitation using biosensors at the point of first contact: a mixed method study in Cambodia

Author

Adhikari, Bipin, Tripura, Rupam, Dysoley, Lek, Callery, James J., Peto, Thomas J., Heng, Chhoeun, Vanda, Thy, Simvieng, Ou, Cassidy-Seyoum, Sarah, Ley, Benedikt, Thriemer, Kamala, Dondorp, Arjen M., and von Seidlein, Lorenz

Abstract

Additional file 2: Observation based quantitative questionnaire at the community setting.

Published
2022
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34. Additional file 2 of Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Abstract

Additional file 2. Parasite Density Estimation.

Published
2022
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35. Additional file 3 of Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Abstract

Additional file 3. EasyScan Go.

Published
2022
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36. Additional file 1 of Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Abstract

Additional file 1. STARD-2015-Checklist.

Published
2022
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38. Additional file 3 of Glucose 6 Phosphate Dehydrogenase (G6PD) quantitation using biosensors at the point of first contact: a mixed method study in Cambodia

Author

Adhikari, Bipin, Tripura, Rupam, Dysoley, Lek, Callery, James J., Peto, Thomas J., Heng, Chhoeun, Vanda, Thy, Simvieng, Ou, Cassidy-Seyoum, Sarah, Ley, Benedikt, Thriemer, Kamala, Dondorp, Arjen M., and von Seidlein, Lorenz

Abstract

Additional file 3: Semi-Structured Interviews (SSIs) Guide.

Published
2022
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39. Good participatory practice for coronavirus disease 2019 (COVID-19) research: the case of a COVID-19 prevention study

Author

Perrone, Carlo, primary, Schilling, William, additional, Callery, James J., additional, Ashley, Elizabeth A., additional, Chambers, Mary, additional, Chase, Hannah, additional, Dahal, Piyush, additional, Kanthawang, Nipaphan, additional, Nedsuwan, Supalert, additional, Hanboonkunupakarn, Borimas, additional, Intralawan, Daranee, additional, Karkey, Abhilasha, additional, Mayxay, Mayfong, additional, Souvong, Vimalay, additional, Tran Minh, Hien, additional, Udas Shakya, Summita, additional, Sharma, Sanjib Kumar, additional, Uranw, Surendra, additional, Vannachione, Souphaphone, additional, Woodrow, Charles, additional, White, Nicholas J., additional, and Cheah, Phaik Yeong, additional

Published
2021
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40. Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion

Author

Imwong, Mallika, primary, Suwannasin, Kanokon, additional, Srisutham, Suttipat, additional, Vongpromek, Ranitha, additional, Promnarate, Cholrawee, additional, Saejeng, Aungkana, additional, Phyo, Aung Pyae, additional, Proux, Stephane, additional, Pongvongsa, Tiengkham, additional, Chea, Nguon, additional, Miotto, Olivo, additional, Tripura, Rupam, additional, Nguyen Hoang, Chau, additional, Dysoley, Lek, additional, Ho Dang Trung, Nghia, additional, Peto, Thomas J., additional, Callery, James J., additional, van der Pluijm, Rob W., additional, Amaratunga, Chanaki, additional, Mukaka, Mavuto, additional, von Seidlein, Lorenz, additional, Mayxay, Mayfong, additional, Thuy-Nhien, Nguyen Thanh, additional, Newton, Paul N., additional, Day, Nicholas P. J., additional, Ashley, Elizabeth A., additional, Nosten, Francois H., additional, Smithuis, Frank M., additional, Dhorda, Mehul, additional, White, Nicholas J., additional, and Dondorp, Arjen M., additional

Published
2021
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43. Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project

Author

Chandna, Arjun, primary, Shwe Nwe Htun, Nan, additional, Peto, Thomas J., additional, Liverani, Marco, additional, Brummaier, Tobias, additional, Phommasone, Koukeo, additional, Ibna Zaman, Sazid, additional, Sandar Zaw, Aye, additional, Batty, Elizabeth, additional, Waithira, Naomi, additional, Richard-Greenblatt, Melissa, additional, Blacksell, Stuart D., additional, Bodhidatta, Ladaporn, additional, Callery, James J., additional, Fagnark, Watcharintorn, additional, Islam, Shayla, additional, Lertcharoenchoke, Sanchai, additional, Mukaka, Mavuto, additional, Pongvongsa, Tiengkham, additional, Schilling, William H.K., additional, Thaipadungpanit, Janjira, additional, Tripura, Rupam, additional, Dondorp, Arjen M., additional, Mayxay, Mayfong, additional, White, Nicholas J., additional, Nosten, François, additional, Smithuis, Frank, additional, Ashley, Elizabeth A., additional, Maude, Richard J., additional, Day, Nicholas P.J., additional, and Lubell, Yoel, additional

Published
2021
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44. Additional file 1 of Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report

Author

Dysoley Lek, Callery, James J., Chea Nguon, Debackere, Mark, Sovannaroth, Siv, Rupam Tripura, Wojnarski, Marius, Piola, Patrice, Soy Ty Khean, Manion, Kylie, Sokomar Nguon, Kunkel, Amber, Vernaeve, Lieven, Peto, Thomas J., Dantzer, Emily, Davoeung, Chan, Etienne, William, Dondorp, Arjen M., Tuseo, Luciano, Seidlein, Lorenz Von, and Jean-Olivier Guintran

Subjects
parasitic diseases
Abstract

Additional file 1: Figure S1. Number of P. falciparum infections treated using variations of mass drug administrations and screen and treat strategies

Published
2020
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45. Chloroquine/ hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting; protocol for a randomised, placebo-controlled prophylaxis study (COPCOV)

Author

Schilling, William HK, primary, Callery, James J., additional, Taylor, Walter, additional, Mukaka, Mavuto, additional, Ekkapongpisit, Maneerat, additional, Watson, James A, additional, Chandna, Arjun, additional, Panapipat, Salwaluk, additional, Tubprasert, Jaruwan, additional, Yuentrakul, Prayoon, additional, Waithira, Naomi, additional, Cope, Tanya, additional, Dhorda, Mehul, additional, Cruz, Cintia, additional, von Seidlein, Lorenz, additional, Milton, Joanne, additional, LLewelyn, Martin, additional, Adler, Amanda, additional, Chotivanich, Kesinee, additional, Cheah, Phaik Yeong, additional, Ashley, Elizabeth A, additional, Mayxay, Mayfong, additional, Dondorp, Arjen M, additional, Phumratanaprapin, Weerapong, additional, Day, Nicholas PJ, additional, and White, Nicholas, additional

Published
2020
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47. Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination

Author

Jacob, Christopher G, primary, Thuy-Nhien, Nguyen, additional, Mayxay, Mayfong, additional, Maude, Richard J, additional, Quang, Huynh Hong, additional, Hongvanthong, Bouasy, additional, Vanisaveth, Viengxay, additional, Duc, Thang Ngo, additional, Rekol, Huy, additional, van der Pluijm, Rob W, additional, Von Seidlein, Lorenz, additional, Fairhurst, Rick M, additional, Nosten, Francois H, additional, Hossain, Md Amir, additional, Park, Naomi, additional, Goodwin, Scott, additional, Ringwald, Pascal, additional, Chindavongsa, Keobouphaphone, additional, Newton, Paul N, additional, Ashley, Elizabeth A, additional, Phalivong, Sonexay, additional, Maude, Rapeephan R, additional, Leang, Rithea, additional, Huch, Cheah, additional, Dong, Le Thanh, additional, Nguyen, Kim-Tuyen, additional, Nhat, Tran Minh, additional, Hien, Tran Tinh, additional, Nguyen, Hoa, additional, Zdrojewski, Nicole, additional, Canavati, Sara E, additional, Sayeed, Abdullah Abu, additional, Uddin, Didar, additional, Buckee, Caroline, additional, Fanello, Caterina I, additional, Onyamboko, Marie, additional, Peto, Thomas, additional, Tripura, Rupam, additional, Amaratunga, Chanaki, additional, Thu, Aung Myint, additional, Delmas, Gilles, additional, Landier, Jordi, additional, Parker, Daniel M, additional, Chau, Nguyen Hoang, additional, Lek, Dysoley, additional, Suon, Seila, additional, Callery, James J, additional, Jittamala, Podjanee, additional, Hanboonkunupakarn, Borimas, additional, Pukrittayakamee, Sasithon, additional, Phyo, Aung Pyae, additional, Smithuis, Frank, additional, Lin, Khin, additional, Thant, Myo, additional, Hlaing, Tin Maung, additional, Satpathi, Parthasarathi, additional, Satpathi, Sanghamitra, additional, Behera, Prativa K, additional, Tripura, Amar, additional, Baidya, Subrata, additional, Valecha, Neena, additional, Anvikar, Anupkumar R, additional, Islam, Akhter ul, additional, Faiz, Abul, additional, Kunasol, Chanon, additional, Drury, Eleanor, additional, Kekre, Mihir, additional, Ali, Mozam, additional, Love, Katie, additional, Rajatileka, Shavanthi, additional, Jeffreys, Anna E, additional, Rowlands, Kate, additional, Hubbart, Christina S, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Kotanan, Namfon, additional, Wongnak, Phrutsamon, additional, Garcia, Jacob Almagro, additional, Pearson, Richard D, additional, Ariani, Cristina V, additional, Chookajorn, Thanat, additional, Malangone, Cinzia, additional, Nguyen, T, additional, Stalker, Jim, additional, Jeffery, Ben, additional, Keatley, Jonathan, additional, Johnson, Kimberly J, additional, Muddyman, Dawn, additional, Chan, Xin Hui S, additional, Sillitoe, John, additional, Amato, Roberto, additional, Simpson, Victoria, additional, Gonçalves, Sonia, additional, Rockett, Kirk, additional, Day, Nicholas P, additional, Dondorp, Arjen M, additional, Kwiatkowski, Dominic P, additional, and Miotto, Olivo, additional

Published
2020
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48. Initiating a network to support engagement between health researchers and schools: recommendations from an international meeting of schools engagement practitioners held in Kilifi, Kenya

Author

Davies, Alun, primary, Mwango, Grace, additional, Appiah, Bernard, additional, Callery, James J., additional, Duy Thanh, Vu, additional, Gumede, Nozibusiso, additional, Inglis, Robert, additional, McCracken, Shane, additional, Mkoola, Kestern, additional, Montjane, Kagisho, additional, Ochanda, Alice, additional, Shonai, Charity, additional, and Woods-Townsend, Kathryn, additional

Published
2020
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49. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

Author

van der Pluijm, Rob W, primary, Tripura, Rupam, additional, Hoglund, Richard M, additional, Pyae Phyo, Aung, additional, Lek, Dysoley, additional, ul Islam, Akhter, additional, Anvikar, Anupkumar R, additional, Satpathi, Parthasarathi, additional, Satpathi, Sanghamitra, additional, Behera, Prativa Kumari, additional, Tripura, Amar, additional, Baidya, Subrata, additional, Onyamboko, Marie, additional, Chau, Nguyen Hoang, additional, Sovann, Yok, additional, Suon, Seila, additional, Sreng, Sokunthea, additional, Mao, Sivanna, additional, Oun, Savuth, additional, Yen, Sovannary, additional, Amaratunga, Chanaki, additional, Chutasmit, Kitipumi, additional, Saelow, Chalermpon, additional, Runcharern, Ratchadaporn, additional, Kaewmok, Weerayuth, additional, Hoa, Nhu Thi, additional, Thanh, Ngo Viet, additional, Hanboonkunupakarn, Borimas, additional, Callery, James J, additional, Mohanty, Akshaya Kumar, additional, Heaton, James, additional, Thant, Myo, additional, Gantait, Kripasindhu, additional, Ghosh, Tarapada, additional, Amato, Roberto, additional, Pearson, Richard D, additional, Jacob, Christopher G, additional, Gonçalves, Sónia, additional, Mukaka, Mavuto, additional, Waithira, Naomi, additional, Woodrow, Charles J, additional, Grobusch, Martin P, additional, van Vugt, Michele, additional, Fairhurst, Rick M, additional, Cheah, Phaik Yeong, additional, Peto, Thomas J, additional, von Seidlein, Lorenz, additional, Dhorda, Mehul, additional, Maude, Richard J, additional, Winterberg, Markus, additional, Thuy-Nhien, Nguyen Thanh, additional, Kwiatkowski, Dominic P, additional, Imwong, Mallika, additional, Jittamala, Podjanee, additional, Lin, Khin, additional, Hlaing, Tin Maung, additional, Chotivanich, Kesinee, additional, Huy, Rekol, additional, Fanello, Caterina, additional, Ashley, Elizabeth, additional, Mayxay, Mayfong, additional, Newton, Paul N, additional, Hien, Tran Tinh, additional, Valecha, Neena, additional, Smithuis, Frank, additional, Pukrittayakamee, Sasithon, additional, Faiz, Abul, additional, Miotto, Olivo, additional, Tarning, Joel, additional, Day, Nicholas P J, additional, White, Nicholas J, additional, Dondorp, Arjen M, additional, van der Pluijm, Rob W, additional, Phyo, Aung Pyae, additional, Thuy-Nhien, Nguyen T, additional, Valeche, Neena, additional, and Day, Nicholas PJ, additional

Published
2020
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50. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparummalaria: a multicentre, open-label, randomised clinical trial

Author

van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, Dondorp, Arjen M, van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Phyo, Aung Pyae, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen T, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valeche, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas PJ, White, Nicholas J, and Dondorp, Arjen M

Abstract

Artemisinin and partner-drug resistance in Plasmodium falciparumare major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance.

Published
2020
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