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4. Preoperative nutritional support to tackle morbidity in multivisceral resection for retroperitoneal sarcoma. Early outcomes from a novel nutritional prehabilitation program in a prospective cohort

Author

Baia, Marco, Zanframundo, Claudia, Ljevar, Silva, Della Valle, Serena, Misotti, Alessandro, Rampello, Nicolò Nicolo, Proto, Paolo, Callegaro, Dario, Colombo, Chiara, Radaelli, Stefano, Sanfilippo, Roberta, Sangalli, Claudia, Morosi, Carlo, Pasquali, Sandro, Miceli, Rosalba, Gronchi, Alessandro, and Fiore, Marco

Published
2024
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5. Radiomic features of primary retroperitoneal sarcomas: a prognostic study

Author

Pasquali, Sandro, Iadecola, Sara, Vanzulli, Andrea, Infante, Gabriele, Bologna, Marco, Corino, Valentina, Greco, Gabriella, Vigorito, Raffaella, Morosi, Carlo, Beretta, Alessia, Percio, Stefano, Vallacchi, Viviana, Collini, Paola, Sanfilippo, Roberta, Fabbroni, Chiara, Stacchiotti, Silvia, Fiore, Marco, Huang, Paul, Benelli, Matteo, Mainardi, Luca, Miceli, Rosalba, Gronchi, Alessandro, and Callegaro, Dario

Published
2024
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8. Clinical recommendations for treatment of localized angiosarcoma: A consensus paper by the Italian Sarcoma Group

Author

Palassini, Elena, Baldi, Giacomo Giulio, Sulfaro, Sara, Barisella, Marta, Bianchi, Giuseppe, Campanacci, Domenico, Fiore, Marco, Gambarotti, Marco, Gennaro, Massimiliano, Morosi, Carlo, Navarria, Federico, Palmerini, Emanuela, Sangalli, Claudia, Sbaraglia, Marta, Trama, Annalisa, Asaftei, Sebastian, Badalamenti, Giuseppe, Bertulli, Rossella, Bertuzzi, Alexia Francesca, Biagini, Roberto, Buonadonna, Angela, Brunello, Antonella, Callegaro, Dario, Cananzi, Ferdinando, Cianchetti, Marco, Collini, Paola, Comandini, Danila, Curcio, Annalisa, D'Ambrosio, Lorenzo, De Pas, Tommaso, Dei Tos, Angelo Paolo, Ferraresi, Virginia, Ferrari, Andrea, Franchi, Alessandro, Frezza, Anna Maria, Fumagalli, Elena, Ghilli, Matteo, Greto, Daniela, Grignani, Giovanni, Guida, Michele, ibrahim, Toni, Krengli, Marco, Luksch, Roberto, Marrari, Andrea, Mastore, Marinella, Merlini, Alessandra, Milano, Giuseppe Maria, Navarria, Piera, Pantaleo, Maria Abbondanza, Parafioriti, Antonina, Pellegrini, Ilaria, Pennacchioli, Elisabetta, Rastrelli, Marco, Setola, Elisabetta, Tafuto, Salvatore, Turano, Salvatore, Valeri, Sergio, Vincenzi, Bruno, Vitolo, Viviana, Ivanescu, Andrei, Paloschi, Fiammetta, Casali, Paolo Giovanni, Gronchi, Alessandro, and Stacchiotti, Silvia

Published
2024
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9. New Sarculator Prognostic Nomograms for Patients With Primary Retroperitoneal Sarcoma: Case Volume Does Matter

Author

Callegaro, Dario, Barretta, Francesco, Raut, Chandrajit P., Johnston, Wendy, Strauss, Dirk C., Honoré, Charles, Bonvalot, Sylvie, Fairweather, Mark, Rutkowski, Piotr, van Houdt, Winan J., Gladdy, Rebecca A., Tirotta, Fabio, Tzanis, Dimitiri, Skoczylas, Jacek, Haas, Rick L., Miceli, Rosalba, Swallow, Carol J., and Gronchi, Alessandro

Published
2024
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14. Management of Locally Recurrent Retroperitoneal Sarcoma in the Adult: An Updated Consensus Approach from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group

Author

Tseng, William W., Swallow, Carol J., Strauss, Dirk C., Bonvalot, Sylvie, Rutkowski, Piotr, Ford, Samuel J., Gonzalez, Ricardo J., Gladdy, Rebecca A., Gyorki, David E., Fairweather, Mark, Lee, Kyo Won, Albertsmeier, Markus, van Houdt, Winan J., Fau, Magalie, Nessim, Carolyn, Grignani, Giovanni, Cardona, Kenneth, Quagliuolo, Vittorio, Grignol, Valerie, Farma, Jeffrey M., Pennacchioli, Elisabetta, Fiore, Marco, Hayes, Andrew, Tzanis, Dimitri, Skoczylas, Jacek, Almond, Max L., Mullinax, John E., Johnston, Wendy, Snow, Hayden, Haas, Rick L., Callegaro, Dario, Smith, Myles J., Bouhadiba, Toufik, Desai, Anant, Voss, Rachel, Sanfilippo, Roberta, Jones, Robin L., Baldini, Elizabeth H., Wagner, Andrew J., Catton, Charles N., Stacchiotti, Silvia, Thway, Khin, Roland, Christina L., Raut, Chandrajit P., and Gronchi, Alessandro

Published
2022
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19. Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results

Author

Callegaro, Dario, Raut, Chandrajit P., Ajayi, Taiwo, Strauss, Dirk, Bonvalot, Sylvie, Ng, Deanna, Stoeckle, Eberhard, Fairweather, Mark, Rutkowski, Piotr, van Houdt, Winan J., Gelderblom, Hans, Sangalli, Claudia, Hayes, Andrew, Honoré, Charles, Gladdy, Rebecca A., Fau, Magali, Haas, Rick, Tzanis, Dimitri, Miah, Aisha B., Chung, Peter, Baldini, Elizabeth H., Marreaud, Sandrine, Litiere, Saskia, Swallow, Carol J., and Gronchi, Alessandro

Published
2023
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24. Survival after Resection of Malignant Peripheral Nerve Sheath Tumors: introducing and validating a novel type-specific prognostic model

Author

Acem, Ibtissam, primary, Steyerberg, Ewout W, additional, Spreafico, Marta, additional, Grünhagen, Dirk J, additional, Callegaro, Dario, additional, Spinner, Robert J, additional, Pendleton, Courtney, additional, Coert, J Henk, additional, Miceli, Rosalba, additional, Abruzzese, Giulia, additional, Flucke, Uta E, additional, Slooff, Willem-Bart M, additional, van Dalen, Thijs, additional, Been, Lukas B, additional, Bonenkamp, Han J, additional, Anten, Monique H M E, additional, Broen, Martinus P G, additional, Bemelmans, Marc H A, additional, Bramer, Jos A M, additional, Schaap, Gerard R, additional, Kievit, Arthur J, additional, van der Hage, Jos, additional, van Houdt, Winan J, additional, van de Sande, Michiel A J, additional, Gronchi, Alessandro, additional, Verhoef, Cornelis, additional, and Martin, Enrico, additional

Published
2024
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25. Retroperitoneal and Extremity Soft Tissue Sarcomas

Author

Callegaro, Dario, Fasih, Samir, Catton, Charles, Dickson, Brendan C., Ferguson, Peter C., Gupta, Abha A., Gladdy, Rebecca A., Wright, Frances C., editor, Escallon, Jaime M., editor, Cukier, Moises, editor, Tsang, Melanie E., editor, and Hameed, Usmaan, editor

Published
2020
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26. Gastrointestinal Stromal Tumor

Author

Callegaro, Dario, Kirsch, Richard, Abdul Razak, Albiruni R., Quereshy, Fayez A., Swallow, Carol J., Wright, Frances C., editor, Escallon, Jaime M., editor, Cukier, Moises, editor, Tsang, Melanie E., editor, and Hameed, Usmaan, editor

Published
2020
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28. ASO Visual Abstract: Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas—A Systematic Review of the Literature

Author

Keung, Emily Z., Krause, Kate J., Maxwell, Jessica, Morris, Carol D., Crago, Aimee M., Houdek, Matthew T., Kane, John, Lewis, Valerae, Callegaro, Dario, Miller, Benjamin, Lazar, Alexander J., Gladdy, Rebecca, Raut, Chandrajit P., Fabbri, Nicola, Al-Refaie, Waddah, Fairweather, Mark, Wong, Sandra L., and Roland, Christina L.

Published
2023
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29. Analysis of Differentiation Changes and Outcomes at Time of First Recurrence of Retroperitoneal Liposarcoma by Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Blay, Jean-Yves, Strauss, Dirk, Rutkowski, Piotr, Ahuja, Nita, Gonzalez, Ricardo, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, Lahat, Guy, De Paoli, Antonino, Pillarisetty, Venu G., Canter, Robert J., Mullen, John T., Pennacchioli, Elisabetta, van Houdt, Winan, Swallow, Carol J., Schrage, Yvonne, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Bagaria, Sanjay P.

Published
2021
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32. Survival after resection of malignant peripheral nerve sheath tumors: Introducing and validating a novel type-specific prognostic model

Author

Zorgeenheid Plastische Chirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Neurochirurgen, Acem, Ibtissam, Steyerberg, Ewout W, Spreafico, Marta, Grünhagen, Dirk J, Callegaro, Dario, Spinner, Robert J, Pendleton, Courtney, Coert, J Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E, Slooff, Willem-Bart M, van Dalen, Thijs, Been, Lukas B, Bonenkamp, Han J, Anten, Monique H M E, Broen, Martinus P G, Bemelmans, Marc H A, Bramer, Jos A M, Schaap, Gerard R, Kievit, Arthur J, van der Hage, Jos, van Houdt, Winan J, van de Sande, Michiel A J, Gronchi, Alessandro, Verhoef, Cornelis, Martin, Enrico, Zorgeenheid Plastische Chirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Neurochirurgen, Acem, Ibtissam, Steyerberg, Ewout W, Spreafico, Marta, Grünhagen, Dirk J, Callegaro, Dario, Spinner, Robert J, Pendleton, Courtney, Coert, J Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E, Slooff, Willem-Bart M, van Dalen, Thijs, Been, Lukas B, Bonenkamp, Han J, Anten, Monique H M E, Broen, Martinus P G, Bemelmans, Marc H A, Bramer, Jos A M, Schaap, Gerard R, Kievit, Arthur J, van der Hage, Jos, van Houdt, Winan J, van de Sande, Michiel A J, Gronchi, Alessandro, Verhoef, Cornelis, and Martin, Enrico

Published
2024

33. Survival after resection of malignant peripheral nerve sheath tumors:Introducing and validating a novel type-specific prognostic model

Author

Acem, Ibtissam, Steyerberg, Ewout W., Spreafico, Marta, Gruenhagen, Dirk J., Callegaro, Dario, Spinner, Robert J., Pendleton, Courtney, Coert, J. Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E., Slooff, Willem-Bart M., van Dalen, Thijs, Been, Lukas B., Bonenkamp, Han J., Anten, Monique H. M. E., Broen, Martinus P. G., Bemelmans, Marc H. A., Bramer, Jos A. M., Schaap, Gerard R., Kievit, Arthur J., van der Hage, Jos, van Houdt, Winan J., van de Sande, Michiel A. J., Gronchi, Alessandro, Verhoef, Cornelis, Martin, Enrico, Acem, Ibtissam, Steyerberg, Ewout W., Spreafico, Marta, Gruenhagen, Dirk J., Callegaro, Dario, Spinner, Robert J., Pendleton, Courtney, Coert, J. Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E., Slooff, Willem-Bart M., van Dalen, Thijs, Been, Lukas B., Bonenkamp, Han J., Anten, Monique H. M. E., Broen, Martinus P. G., Bemelmans, Marc H. A., Bramer, Jos A. M., Schaap, Gerard R., Kievit, Arthur J., van der Hage, Jos, van Houdt, Winan J., van de Sande, Michiel A. J., Gronchi, Alessandro, Verhoef, Cornelis, and Martin, Enrico

Abstract

Background: This study aimed to assess the performance of currently available risk calculators in a cohort of patients with malignant peripheral nerve sheath tumors (MPNST) and to create an MPNST-specific prognostic model including type-specific predictors for overall survival (OS). Methods: This is a retrospective multicenter cohort study of patients with MPNST from 11 secondary or tertiary centers in The Netherlands, Italy and the United States of America. All patients diagnosed with primary MPNST who underwent macroscopically complete surgical resection from 2000 to 2019 were included in this study. A multivariable Cox proportional hazard model for OS was estimated with prespecified predictors (age, grade, size, NF-1 status, triton status, depth, tumor location, and surgical margin). Model performance was assessed for the Sarculator and PERSARC calculators by examining discrimination (C-index) and calibration (calibration plots and observed-expected statistic; O/E-statistic). Internal-external cross-validation by different regions was performed to evaluate the generalizability of the model. Results: A total of 507 patients with primary MPNSTs were included from 11 centers in 7 regions. During follow-up (median 8.7 years), 211 patients died. The C-index was 0.60 (95% CI 0.53-0.67) for both Sarculator and PERSARC. The MPNST-specific model had a pooled C-index of 0.69 (95%CI 0.65-0.73) at validation, with adequate discrimination and calibration across regions. Conclusions: The MPNST-specific MONACO model can be used to predict 3-, 5-, and 10-year OS in patients with primary MPNST who underwent macroscopically complete surgical resection. Further validation may refine the model to inform patients and physicians on prognosis and support them in shared decision-making.

Published
2024

34. Postoperative Morbidity After Resection of Recurrent Retroperitoneal Sarcoma: A Report from the Transatlantic Australasian RPS Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Rutkowski, Piotr, Blay, Jean-Yves, Strauss, Dirk, Gonzalez, Ricardo, Ahuja, Nita, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, De Paoli, Antonino, Pillarisetty, Venu G., Swallow, Carol J., Bagaria, Sanjay P., Canter, Robert J., Mullen, John T., Schrage, Yvonne, Pennacchioli, Elisabetta, van Houdt, Winan, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Lahat, Guy

Published
2021
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35. Current Management of Desmoid Tumors: A Review.

Author

Kasper, Bernd, Baldini, Elizabeth H., Bonvalot, Sylvie, Callegaro, Dario, Cardona, Kenneth, Colombo, Chiara, Corradini, Nadège, Crago, Aimee M., Dei Tos, Angelo P., Dileo, Palma, Elnekave, Eldad, Erinjeri, Joseph P., Navid, Fariba, Farma, Jeffrey M., Ferrari, Andrea, Fiore, Marco, Gladdy, Rebecca A., Gounder, Mrinal, Haas, Rick L., and Husson, Olga

Published
2024
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36. Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall.

Author

Chadha, Madhumeeta, Iadecola, Sara, Jenks, Andrew, Pankova, Valeriya, Tam, Yuen Bun, Burns, Jessica, Arthur, Amani, Wilding, Christopher P., Chen, Liang, Chudasama, Priya, Callegaro, Dario, Strauss, Dirk C., Thway, Khin, Gronchi, Alessandro, Jones, Robin L., Miceli, Rosalba, Pasquali, Sandro, and Huang, Paul H.

Subjects
CELL cycle proteins, SARCOMA, DNA replication, OVERALL survival, DRUG target
Abstract

Background: High‐risk soft tissue sarcomas of the extremities and trunk wall (eSTS), as defined by the Sarculator nomogram, are more likely to benefit from (neo)adjuvant anthracycline‐based therapy compared to low/intermediate‐risk patients. The biology underpinning these differential treatment outcomes remain unknown. Methods: We analysed proteomic profiles and clinical outcomes of 123 eSTS patients. A Cox model for overall survival including the Sarculator was fitted to individual data to define four risk groups. A DNA replication protein signature‐Sarcoma Proteomic Module 6 (SPM6) was evaluated for association with clinicopathological factors and risk groups. SPM6 was added as a covariate together with Sarculator in a multivariable Cox model to assess improvement in prognostic risk stratification. Results: DNA replication and cell cycle proteins were upregulated in high‐risk versus very low‐risk patients. Evaluation of the functional effects of CRISPR‐Cas9 gene knockdown of proteins enriched in high‐risk patients using the cancer cell line encyclopaedia database identified candidate drug targets. SPM6 was significantly associated with tumour malignancy grade (p = 1.6e‐06), histology (p = 1.4e‐05) and risk groups (p = 2.6e‐06). Cox model analysis showed that SPM6 substantially contributed to a better calibration of the Sarculator nomogram (Index of Prediction Accuracy = 0.109 for Sarculator alone versus 0.165 for Sarculator + SPM6). Conclusions: Risk stratification of patient with STS is defined by distinct biological pathways across a range of cancer hallmarks. Incorporation of SPM6 protein signature improves prognostic risk stratification of the Sarculator nomogram. This study highlights the utility of integrating protein signatures for the development of next‐generation nomograms. [ABSTRACT FROM AUTHOR]

Published
2024
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39. The natural history of epithelioid sarcoma. A retrospective multicentre case-series within the Italian Sarcoma Group

Author

Frezza, Anna Maria, Sbaraglia, Marta, Lo Vullo, Salvatore, Baldi, Giacomo Giulio, Simeone, Noemi, Frenos, Filippo, Campanacci, Domenico, Stacchiotti, Silvia, Pasquali, Sandro, Callegaro, Dario, Gambarotti, Marco, Barisella, Marta, Palomba, Annarita, Mariani, Luigi, Casali, Paolo G., Dei Tos, Angelo Paolo, and Gronchi, Alessandro

Published
2020
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40. Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years

Author

Callegaro, Dario, Raut, Chandrajit P., Ng, Deanna, Strauss, Dirk C., Honoré, Charles, Stoeckle, Eberhard, Bonvalot, Sylvie, Haas, Rick L., Vassos, Nikolaos, Conti, Lorenzo, Gladdy, Rebecca A., Fairweather, Mark, van Houdt, Winan, Schrage, Yvonne, van Coevorden, Frits, Rutkowski, Piotr, Miceli, Rosalba, Gronchi, Alessandro, and Swallow, Carol J.

Published
2021
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44. Development and external validation of a dynamic prognostic nomogram for primary extremity soft tissue sarcoma survivors

Author

Callegaro, Dario, Miceli, Rosalba, Bonvalot, Sylvie, Ferguson, Peter C., Strauss, Dirk C., van Praag, Veroniek V.M., Levy, Antonin, Griffin, Anthony M., Hayes, Andrew J., Stacchiotti, Silvia, Pèchoux, Cecile Le, Smith, Myles J., Fiore, Marco, Tos, Angelo Paolo Dei, Smith, Henry G., Catton, Charles, Szkandera, Joanna, Leithner, Andreas, van de Sande, Michiel A.J., Casali, Paolo G., Wunder, Jay S., and Gronchi, Alessandro

Published
2019
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46. Correction to: Postoperative Morbidity After Resection of Recurrent Retroperitoneal Sarcoma: A Report from the Transatlantic Australasian RPS Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Rutkowski, Piotr, Blay, Jean-Yves, Strauss, Dirk, Gonzalez, Ricardo, Ahuja, Nita, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, De Paoli, Antonino, Pillarisetty, Venu G., Swallow, Carol J., Bagaria, Sanjay P., Canter, Robert J., Mullen, John T., Schrage, Yvonne, Pennacchioli, Elisabetta, van Houdt, Winan, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Lahat, Guy

Published
2022
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47. Correction: ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Blay, Jean-Yves, Strauss, Dirk, Rutkowski, Piotr, Ahuja, Nita, Gonzalez, Ricardo, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, Lahat, Guy, De Paoli, Antonino, Pillarisetty, Venu G., Canter, Robert J., Mullen, John T., Pennacchioli, Elisabetta, van Houdt, Winan, Swallow, Carol J., Schrage, Yvonne, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Bagaria, Sanjay P.

Published
2022
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48. Correction to: Analysis of Differentiation Changes and Outcomes at Time of First Recurrence of Retroperitoneal Liposarcoma by Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Blay, Jean-Yves, Strauss, Dirk, Rutkowski, Piotr, Ahuja, Nita, Gonzalez, Ricardo, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, Lahat, Guy, De Paoli, Antonino, Pillarisetty, Venu G., Canter, Robert J., Mullen, John T., Pennacchioli, Elisabetta, van Houdt, Winan, Swallow, Carol J., Schrage, Yvonne, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Bagaria, Sanjay P.

Published
2022
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50. High-risk soft tissue sarcomas treated with perioperative chemotherapy: Improving prognostic classification in a randomised clinical trial

Author

Pasquali, Sandro, Colombo, Chiara, Pizzamiglio, Sara, Verderio, Paolo, Callegaro, Dario, Stacchiotti, Silvia, Martin Broto, Javier, Lopez-Pousa, Antonio, Ferrari, Stefano, Poveda, Andres, De Paoli, Antonino, Quagliuolo, Vittorio, Jurado, Josefina Cruz, Comandone, Alessandro, Grignani, Giovanni, De Sanctis, Rita, Palassini, Elena, Llomboart-Bosch, Antonio, Dei Tos, Angelo Paolo, Casali, Paolo G., Picci, Piero, and Gronchi, Alessandro

Published
2018
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