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34 results on '"Callà, Cinzia"'

1. Salivary biomarkers in COVID-19 patients: the rabbit out of the hat!

Author

Napodano, Cecilia, primary, Callà, Cinzia Anna, additional, Fiorito, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Cesare, Tiziana Di, additional, Passali, Giulio Cesare, additional, Santo, Riccardo Di, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2024
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4. Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients

Author

Pellicano, Chiara, primary, Colalillo, Amalia, additional, Cusano, Giuseppina, additional, Palladino, Andrea, additional, Pellegrini, Marica, additional, Callà, Cinzia Anna Maria, additional, Mazzuccato, Giorgia, additional, Carnazzo, Valeria, additional, Pignalosa, Stefano, additional, Di Biase, Luigi, additional, Marino, Mariapaola, additional, Basile, Umberto, additional, and Rosato, Edoardo, additional

Published
2023
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5. Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace

Author

Pocino, Krizia, primary, Stefanile, Annunziata, additional, Basile, Valerio, additional, Napodano, Cecilia, additional, D’Ambrosio, Francesca, additional, Di Santo, Riccardo, additional, Callà, Cinzia Anna Maria, additional, Gulli, Francesca, additional, Saporito, Raffaele, additional, Ciasca, Gabriele, additional, Equitani, Francesco, additional, Basile, Umberto, additional, and Marino, Mariapaola, additional

Published
2022
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6. Circulating and Salivary NGF and BDNF Levels in SARS-CoV-2 Infection: Potential Predictor Biomarkers of COVID-19 Disease—Preliminary Data

Author

Biamonte, Filippo, primary, Re, Agnese, additional, Balzamino, Bijorn Omar, additional, Ciasca, Gabriele, additional, Santucci, Daniela, additional, Napodano, Cecilia, additional, Nocca, Giuseppina, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Basile, Umberto, additional, Micera, Alessandra, additional, and Callà, Cinzia Anna Maria, additional

Published
2022
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8. Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace.

Author

Pocino, Krizia, Stefanile, Annunziata, Basile, Valerio, Napodano, Cecilia, D'Ambrosio, Francesca, Di Santo, Riccardo, Callà, Cinzia Anna Maria, Gulli, Francesca, Saporito, Raffaele, Ciasca, Gabriele, Equitani, Francesco, Basile, Umberto, and Marino, Mariapaola

Subjects
HEPATOCELLULAR carcinoma, SOMATIC mutation, CYTOKINES, GROWTH factors, ANGIOPOIETINS
Abstract

Hepatocellular carcinoma (HCC) represents a worldwide health matter with a major care burden, high prevalence, and poor prognosis. Its pathogenesis mainly varies depending on the underlying etiological factors, although it develops from liver cirrhosis in the majority of cases. This review summarizes the role of the most interesting soluble factors as biomarkers for early diagnosis and as recommended targets for treatment in accordance with the new challenges in precision medicine. In the premalignant environment, inflammatory cells release a wide range of cytokines, chemokines, growth factors, prostaglandins, and proangiogenic factors, making the liver environment more suitable for hepatocyte tumor progression that starts from acquired genetic mutations. A complex interaction of pro-inflammatory (IL-6, TNF-α) and anti-inflammatory cytokines (TGF-α and -β), pro-angiogenic molecules (including the Angiopoietins, HGF, PECAM-1, HIF-1α, VEGF), different transcription factors (NF-kB, STAT-3), and their signaling pathways are involved in the development of HCC. Since cytokines are expressed and released during the different stages of HCC progression, their measurement, by different available methods, can provide in-depth information on the identification and management of HCC. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Salivary Biomarkers in COVID-19 Patients: Towards a Wide-Scale Test for Monitoring Disease Activity

Author

Napodano, Cecilia, primary, Callà, Cinzia, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Di Cesare, Tiziana, additional, Passali, Giulio Cesare, additional, Di Santo, Riccardo, additional, Stefanile, Annunziata, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2021
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13. Salivary Biomarkers in COVID-19 Patients: The Rabbit out of the Hat!

Author

Napodano, Cecilia, primary, Callà, Cinzia, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Di Cesare, Tiziana, additional, Passali, Giulio Cesare, additional, Disanto, Riccardo, additional, Stefanile, Annunziata, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2021
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14. Biochemical and nutritional characteristics of buffalo meat and potential implications on human health for a personalized nutrition

Author

Tamburrano, Andrea, primary, Tavazzi, Barbara, additional, Callà, Cinzia Anna Maria, additional, Amorini, Angela Maria, additional, Lazzarino, Giacomo, additional, Vincenti, Sara, additional, Zottola, Tiziana, additional, Campagna, Maria Concetta, additional, Moscato, Umberto, additional, and Laurenti, Patrizia, additional

Published
2019
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19. Controlled release of 18-β-glycyrrhetic acid by nanodelivery systems increases cytotoxicity on oral carcinoma cell line

Author

Cacciotti, Ilaria, primary, Chronopoulou, Laura, additional, Palocci, Cleofe, additional, Amalfitano, Adriana, additional, Cantiani, Monica, additional, Cordaro, Massimo, additional, Lajolo, Carlo, additional, Callà, Cinzia, additional, Boninsegna, Alma, additional, Lucchetti, Donatella, additional, Gallenzi, Patrizia, additional, Sgambato, Alessandro, additional, Nocca, Giuseppina, additional, and Arcovito, Alessandro, additional

Published
2018
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23. Multicenter evaluation of an enzymatic method for glycated albumin

Author

Paleari, Renata, primary, Bonetti, Graziella, additional, Callà, Cinzia, additional, Carta, Mariarosa, additional, Ceriotti, Ferruccio, additional, Di Gaetano, Nicola, additional, Ferri, Marilisa, additional, Guerra, Elena, additional, Lavalle, Gabriella, additional, Cascio, Claudia Lo, additional, Martino, Francesca Gabriela, additional, Montagnana, Martina, additional, Moretti, Marco, additional, Santini, Gabriele, additional, Scribano, Donata, additional, Testa, Roberto, additional, Vero, Anna, additional, and Mosca, Andrea, additional

Published
2017
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24. Physiopathology of Bone Modifications in β-Thalassemia

Author

Perisano, Carlo, Marzetti, Emanuele, Spinelli, Maria Silvia, Callà, Cinzia Anna Maria, Graci, Calogero, and Maccauro, Giulio

Subjects
Article Subject
Abstract

β-thalassemia major (βTM) or Cooley anemia is characterized by significantly reduced or absent synthesis of β-globin chains, which induces important pathologic consequences including hemolytic anemia, altered erythropoiesis, and bone marrow overstimulation. The pathogenesis of bone changes in patients with βTM is not yet completely understood. However, an unbalance in bone mineral turnover resulting from increased resorption and suppression of osteoblast activity has been detected in βTM patients. The abnormal regulation of bone metabolism may be related to hormonal and genetic factors, iron overload and iron chelation therapy, nutritional deficits, and decreased levels of physical activity. Here, we review the most recent findings on the physiopathology of bone abnormalities in βTM. Clinical presentation and radiological features of βTM-related bone changes are also discussed.

Published
2012
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29. Homocysteine, cysteine, folate and vitamin B12status in type 2 diabetic patients with chronic kidney disease

Author

Pastore, Anna, Noce, Annalisa, Di Giovamberardino, Gianna, De Stefano, Alessandro, Callà, Cinzia, Zenobi, Rossella, Dessì, Mariarita, and Di Daniele, Nicola

Abstract

Hyperhomocysteinemia (hHcy) is a risk factor in the progression of chronic kidney disease (CKD). In type 2 diabetes (T2D), hHcy is strongly associated with increased risk of cardiovascular disease. Vitamin B12and folic acid supplementation have been reported to lower homocysteine (tHcy) levels, but no data on plasma tHcy, cysteine (Cys), folate and vitamin B12levels in T2D-CKD patients are reported. tHcy and Cys levels were analyzed in 178 T2D-CKD patients by high performance liquid chromatography (HPLC) with fluorescence detection. In addition, we determined folate and vitamin B12levels using a chemiluminescence method. tHcy and Cys levels were increased in T2D patients, and this rise positively correlated with the CKD stage (P < 0.001). Folate levels were comparable to controls at various CKD stages, whereas vitamin B12levels were lower, except at stage IV. We did not find any correlation between B-vitamins and levels of tHcy and Cys, regardless of the CKD stage. This is the first study reporting tHcy, Cys and B-vitamins status in T2D-CKD patients. Although limited to our cohort of 178 patients, our findings could be helpful in clarifying the conflicting literature regarding B-vitamins supplementation. Further studies are necessary before any Hcy-lowering therapy can be safely established in T2D-CKD subjects.

Published
2015
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32. Correlation Between Metabolic Syndrome, Periodontitis and Reactive Oxygen Species Production. A Pilot Study

Author

Patrizia Gallenzi, Alessandro Arcovito, Adriana Amalfitano, Cinzia Anna Maria Calla, G. Mingrone, Monica Cantiani, Massimo Cordaro, Gianrico Spagnuolo, Romeo Patini, Giuseppina Nocca, Patini, Romeo, Gallenzi, Patrizia, Spagnuolo, Gianrico, Cordaro, Massimo, Cantiani, Monica, Amalfitano, Adriana, Arcovito, Alessandro, Callà, Cinzia, Mingrone, Gertrude, and Nocca, Giuseppina

Subjects
medicine.medical_specialty, Chemiluminescence, Inflammation, 030204 cardiovascular system & hematology, Biology, Article, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, ROS metabolism, law, Internal medicine, medicine, Leukocytes, Obesity, Periodontitis, General Dentistry, Settore BIO/10 - BIOCHIMICA, chemistry.chemical_classification, Reactive oxygen species, Zymosan, ROS, 030206 dentistry, Metabolism, medicine.disease, Metabolic syndrome, Endocrinology, chemistry, Analysis of variance, medicine.symptom
Abstract

Background and Objective: Metabolic syndrome (MetS) is associated with an increased risk of periodontitis even if the mechanism is unknown. Since both MetS and periodontitis are characterized by an alteration of inflammation status, the aim of this pilot study was to determine if differences in ROS metabolism of phagocytes isolated from (A) patients with MetS, (B) patients with both MetS and mild periodontitis, (C) healthy subjects and (D) normal weight subjects with mild periodontitis, were present. Methods: ROS metabolism was studied by a Chemiluminescence (CL) technique: the system was made up of luminol (100 nmol/L) and cells (1 × 105) in the presence or absence of stimulus constituted by opsonized zymosan (0.5 mg). The final volume (1.0 mL) was obtained using modified KRP buffer. ROS production was measured at 25°C for 2 h, using an LB 953 luminometer (Berthold, EG & G Co, Germany). All the experiments were performed in triplicate. Statistical Analysis: All results are mean ± standard deviation (SD). The group of means was compared by the analysis of variance "(ANOVA)". A value of p < 0.05 was considered significant. Results: Results showed that basal ROS production (both from PMNs and from PBMs) of groups A, B and D was increased with respect to that obtained from group C (p Conclusion: These results are congruent with literature data, although the actual clinical relevance of the phenomenon remains to be evaluated.

Published
2017

33. Quantitative Determination of 18-β-Glycyrrhetinic Acid in HepG2 Cell Line by High Performance Liquid Chromatography Method

Author

Cinzia Anna Maria Calla, Stefano Angelo Santini, Giuseppina Nocca, Diana Valeria Rossetti, Massimo Cordaro, Gianrico Spagnuolo, Adriana Amalfitano, Luca Marigo, Nocca, Giuseppina, Callà, Cinzia, Santini, Stefano Angelo, Amalfitano, Adriana, Marigo, Luca, Rossetti, Diana Valeria, Spagnuolo, Gianrico, and Cordaro, Massimo

Subjects
0301 basic medicine, lcsh:QD71-142, Chromatography, Article Subject, Chemistry, Calibration curve, lcsh:Analytical chemistry, High-performance liquid chromatography, Standard deviation, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Hepg2 cells, Standard addition, Phase (matter), HPLC, 18-β-glycyrrhetinic acid, Settore BIO/10 - BIOCHIMICA, Tetrahydrofuran, Line (formation), Research Article
Abstract

A reverse phase high performance liquid chromatographic (RP-HPLC) method was developed for identification and estimation of 18-β-glycyrrhetinic acid (GA) in HepG2 cell line. The analysis was carried out using a JASCO HPLC system with a C-18 (3 μm) Supelco reversed phase column (150 x 4.7 mm) using a mobile phase of 80% CH3OH and 20% of CH3CN: tetrahydrofuran: water (10:80:10, v/v/v). The method was linear in the concentration range of 1.5–120 μg /mL (n = 5). The LOD and LOQ were determined based on standard deviation of the y-intercept and the slope of the calibration curve. The LOD and LOQ values were found to be 11.46 μg/mL and 34.72 μg/mL, respectively. The mean percentage recovery by standard addition experiments of GA is 92.4 % ± 5.2%. The intracellular GA concentration value, obtained as mean of five different determinations, was 45.8 ± 7.45 μg/mL. We have developed a HPLC-UV method for quantitative determination of GA inside cells, with advantages in the cost reduction and economy of the analytical process.

Published
2018

34. Chromographic Analysis and Cytotoxic Effects of Chlorhexidine and Sodium Hypochlorite Reaction Mixtures

Author

Gianrico Spagnuolo, Giuseppina Nocca, Giuseppe Ettore Martorana, Cinzia Anna Maria Calla, Sandro Rengo, Hany Mohamed Aly Ahmed, Gianluca Gambarini, Nocca, Giuseppina, Ahmed, Hany Mohamed Aly, Martorana, Giuseppe Ettore, Callà, Cinzia, Gambarini, Gianluca, Rengo, Sandro, and Spagnuolo, Gianrico

Subjects
Sodium Hypochlorite, Inorganic chemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, para-chloroaniline, Toxicity Tests, medicine, Cytotoxic T cell, Humans, Centrifugation, General Dentistry, Settore BIO/10 - BIOCHIMICA, Chromatography, High Pressure Liquid, Chromatography, Aniline Compounds, Brown precipitate, Chemistry, Para-chloroaniline, Chlorhexidine, 030206 dentistry, brown precipitate, chlorhexidine, cytotoxicity, sodium hypochlorite, dentistry (all), 030220 oncology & carcinogenesis, Sodium hypochlorite, Dentistry (all), medicine.drug
Abstract

Introduction The literature reveals controversies regarding the formation of para-chloroaniline (PCA) when chlorhexidine (CHX) is mixed with sodium hypochlorite (NaOCl). This study aimed to investigate the stability of PCA in the presence of NaOCl and to examine the in vitro cytotoxic effects of CHX/NaOCl reaction mixtures. Methods Different volumes of NaOCl were added to CHX (mix 1) or PCA (mix 2). Upon centrifugation, the supernatant and precipitate fractions collected from samples were analyzed using high-performance liquid chromatography. The cytotoxic effects of both fractions were examined on human periodontal ligament and 3T3 fibroblast cell lines. Results High-performance liquid chromatographic analysis showed no PCA signal when NaOCl was mixed with CHX (mix 1). In mix 2, the intensity of PCA was decreased when NaOCl was added to PCA, and chromatographic signals, similar to that of CHX/NaOCl, were also observed. The mortality of precipitates exerted on both cell lines was lower compared with that of supernatants. Conclusions The discrepancy in the data from the literature could be caused by the instability of the PCA in the presence of NaOCl. The CHX/NaOCl reaction mixture exhibits a wide range of cytotoxic effects.

Published
2016

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